MCID: ATM075
MIFTS: 40

Autoimmune Encephalitis

Categories: Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for Autoimmune Encephalitis

MalaCards integrated aliases for Autoimmune Encephalitis:

Name: Autoimmune Encephalitis 53
Hashimoto's Encephalitis 73

Classifications:



External Ids:

UMLS 73 C0393639

Summaries for Autoimmune Encephalitis

NIH Rare Diseases : 53 Autoimmune encephalitis refers to a group of conditions that occur when the body's immune system mistakenly attacks healthy brain cells, leading to inflammation of the brain. People with autoimmune encephalitis may have various neurologic and/or psychiatric symptoms. Neurologic symptoms may include impaired memory and cognition, abnormal movements, seizures, and/or problems with balance, speech, or vision. Psychiatric symptoms may include psychosis, aggression, inappropriate sexual behaviors, panic attacks, compulsive behaviors, euphoria or fear. Symptoms may fluctuate, but often progress over days to a few weeks. Symptoms can progress to loss of consciousness or even coma. Autoimmune encephalitis may be associated with antibodies to proteins on the surface of nerve cells, or within nerve cells. Some of these proteins are involved in passing signals between nerve cells. In some cases it occurs in association with cancer (a paraneoplastic syndrome). Research regarding why specific antibodies attack the body's healthy cells is ongoing. Autoimmune encephalitis generally occurs sporadically, in people with no family history of the condition.   Treatment may involve intravenous immunosuppressive therapy, and tumor removal when necessary. Early treatment decreases the likelihood for long-term complications, speeds recovery, and reduces the risk of recurrence (relapse). If not treated, the condition can lead to progressive neurologic deterioration and loss of life.

MalaCards based summary : Autoimmune Encephalitis, also known as hashimoto's encephalitis, is related to encephalitis and hallucinogen dependence. An important gene associated with Autoimmune Encephalitis is CNTNAP2 (Contactin Associated Protein Like 2), and among its related pathways/superpathways are Neuroscience and Eicosanoid ligand-binding receptors. The drugs Epoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and t cells, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Autoimmune encephalitis is a type of encephalitis that can result from a number of autoimmune diseases... more...

Related Diseases for Autoimmune Encephalitis

Diseases in the Encephalitis family:

Viral Encephalitis Autoimmune Encephalitis

Diseases related to Autoimmune Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 encephalitis 10.8
2 hallucinogen dependence 10.4 CNR1 FAAH
3 polysubstance abuse 10.4 CNR1 FAAH
4 post-traumatic stress disorder 10.3 CNR1 FAAH
5 alcohol abuse 10.3 CNR1 FAAH
6 amnestic disorder 10.2 CNR1 LGI1
7 internuclear ophthalmoplegia 10.2 HCRT LGI1
8 multiple sclerosis 10.0
9 neuronitis 10.0
10 status epilepticus 10.0
11 cannabis dependence 9.9 CNR1 FAAH HCRT
12 creutzfeldt-jakob disease 9.9
13 diverticulitis of colon 9.9 CNR1 TRPV1
14 somatoform disorder 9.9 FAAH TRPV1
15 pain agnosia 9.9 CNR1 TRPV1
16 agnosia 9.9 CNR1 TRPV1
17 epilepsy 9.9
18 glioma 9.9
19 aging 9.8
20 dementia 9.8
21 thymoma 9.8
22 herpes zoster 9.7 IFNG TRPV1
23 bone inflammation disease 9.7 IFNG TRPV1
24 overnutrition 9.7 CNR1 TRPV1
25 intestinal disease 9.7 IFNG TRPV1
26 specific developmental disorder 9.7 CNR1 TRPV1
27 hypersensitivity reaction disease 9.6 IFNG TRPV1
28 small cell cancer of the lung 9.6
29 lung cancer 9.6
30 myasthenia gravis 9.6
31 aceruloplasminemia 9.6
32 malaria 9.6
33 ataxia-oculomotor apraxia 3 9.6
34 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.6
35 brain injury 9.6
36 neuromyelitis optica 9.6
37 traumatic brain injury 9.6
38 lambert-eaton myasthenic syndrome 9.6
39 focal dystonia 9.6
40 optic neuritis 9.6
41 graves' disease 9.6
42 neuritis 9.6
43 factor xiii deficiency 9.6
44 psychotic disorder 9.6
45 demyelinating disease 9.6
46 cerebritis 9.6
47 dystonia 9.6
48 acute disseminated encephalomyelitis 9.6
49 thyroiditis 9.6
50 herpes simplex 9.6

Graphical network of the top 20 diseases related to Autoimmune Encephalitis:



Diseases related to Autoimmune Encephalitis

Symptoms & Phenotypes for Autoimmune Encephalitis

MGI Mouse Phenotypes related to Autoimmune Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 FAAH HCRT IFNG LGI1 TRPV1 CNR1
2 growth/size/body region MP:0005378 9.73 HCRT IFNG LGI1 TRPV1 CNR1 CNTNAP2
3 integument MP:0010771 9.63 IFNG LGI1 TRPV1 CNR1 CNTNAP2 FAAH
4 nervous system MP:0003631 9.56 HCRT IFNG LGI1 S1PR1 TRPV1 CNR1
5 taste/olfaction MP:0005394 8.8 TRPV1 CNR1 CNTNAP2

Drugs & Therapeutics for Autoimmune Encephalitis

Drugs for Autoimmune Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Epoetin alfa Phase 4 113427-24-0
2 Hematinics Phase 4
3
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
4
rituximab Approved Phase 2 174722-31-7 10201696
5
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7 Anti-Infective Agents Phase 1, Phase 2
8 Anti-HIV Agents Phase 1, Phase 2
9 Anti-Retroviral Agents Phase 1, Phase 2
10 Antiviral Agents Phase 1, Phase 2
11 Prednisolone acetate Phase 2
12 Methylprednisolone acetate Phase 2
13 Methylprednisolone Hemisuccinate Phase 2
14 Rho(D) Immune Globulin Phase 2
15 gamma-Globulins Phase 2
16 Pharmaceutical Solutions Phase 2
17 Antibodies Phase 2
18 Immunoglobulins Phase 2
19 Immunoglobulins, Intravenous Phase 2
20 Prednisolone hemisuccinate Phase 2
21 Prednisolone phosphate Phase 2
22 Antirheumatic Agents Phase 2
23 Autoantibodies Phase 2
24
Vigabatrin Approved Not Applicable 68506-86-5, 60643-86-9 5665
25 N-Methylaspartate
26 GABA Agents Not Applicable
27 Neurotransmitter Agents Not Applicable
28 Anticonvulsants Not Applicable
29 Aspartic Acid Nutraceutical

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Recruiting NCT03004209 Phase 4 Erythropoietin
2 IL-2 in Refractory Autoimmune Encephalitis Unknown status NCT02714959 Phase 1, Phase 2 Proleukin
3 IVIG and Rituximab in Antibody-associated Psychosis - SINAPPS2 Recruiting NCT03194815 Phase 2 Intravenous immunoglobulin;Placebo;Rituximab
4 Multicenter and Prospective Clinical Registry Study of Autoimmune Encephalitis in China Unknown status NCT02561260
5 Multicenter and Prospective Clinical Registry Study of Anti-N-methyl-D-aspartate Receptor Encephalitis in Beijing Area Unknown status NCT02443350
6 Multicenter and Prospective Clinical Registry Study of Anti-N-methyl-D-aspartate Receptor Encephalitis in China Unknown status NCT02559089
7 To Explore Cognitive Neural Mechanism of Autoimmune Encephalitis by Using Neuropsychological Tests and Multi-modal MRI Completed NCT03530462 rituximab;cyclophosphamide;Steroids;Intravenous immunoglobulin
8 Sodium Intake in Multiple Sclerosis Completed NCT01846234
9 Mechanisms of Auto-immune Encephalitis Recruiting NCT02905136
10 Immunotherapy in Autoimmune Encephalitis Recruiting NCT03542279 Not Applicable medication immunotherapy group
11 Effect of Vigabatrin in Refractory Autoimmune Encephalitis Patients Recruiting NCT03003143 Not Applicable Vigabatrin 500 MG
12 Antibodies Causing Epilepsy Syndromes: The ACES Study. Recruiting NCT02802475

Search NIH Clinical Center for Autoimmune Encephalitis

Genetic Tests for Autoimmune Encephalitis

Anatomical Context for Autoimmune Encephalitis

MalaCards organs/tissues related to Autoimmune Encephalitis:

41
Brain, Testes, T Cells, Thyroid, Lung, Neutrophil, Bone

Publications for Autoimmune Encephalitis

Articles related to Autoimmune Encephalitis:

(show top 50) (show all 204)
# Title Authors Year
1
Autoimmune encephalitis (NMDAR antibody) in a patient receiving chronic post-transplant immunosuppression. ( 29588384 )
2018
2
Isolated pseudotumoural demyelination: A focal, monophasic autoimmune encephalitis? ( 29525395 )
2018
3
Predictive values and specificity of electroencephalographic findings in autoimmune encephalitis diagnosis. ( 29738958 )
2018
4
Coexistence of Lambert-Eaton myasthenic syndrome and autoimmune encephalitis with anti-CRMP5/CV2 and anti-GABAB receptor antibodies in small cell lung cancer: A case report. ( 29742721 )
2018
5
EEG Differences in Two Clinically Similar Rapid Dementias: Voltage-Gated Potassium Channel Complex-Associated Autoimmune Encephalitis and Creutzfeldt-Jakob Disease. ( 29788790 )
2018
6
Perfusion Imaging in Autoimmune Encephalitis. ( 29854534 )
2018
7
Evaluation and Management of Autoimmune Encephalitis: A Clinical Overview for the Practicing Child Psychiatrist. ( 29157501 )
2018
8
Autoimmune encephalitis and psychiatric disorders. ( 29609960 )
2018
9
Autoimmune Encephalitis Following Herpes Simplex Virus Encephalitis in an Infant. ( 29629704 )
2018
10
Autoimmune Encephalitis Epidemiology and a comparison to Infectious Encephalitis. ( 29293273 )
2018
11
Autoimmune encephalitis associated with two antibodies. ( 29928585 )
2018
12
Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice. ( 29770132 )
2018
13
Autoimmune encephalitis associated with glutamic acid decarboxylase antibodies: a case series. ( 29349679 )
2018
14
Practice Current: When do you suspect autoimmune encephalitis and what is the role of antibody testing? ( 29517071 )
2018
15
Pediatric <i>N</i>-Methyl-D-Aspartate Receptor Autoimmune Encephalitis. ( 29899790 )
2018
16
Glioblastoma as differential diagnosis of autoimmune encephalitis. ( 29383516 )
2018
17
Analysis and discussion of the rare complication of autoimmune encephalitis: Two case reports. ( 29979382 )
2018
18
Febrile infection-related epilepsy syndrome (FIRES) with super-refractory status epilepticus revealing autoimmune encephalitis due to GABA<sub>A</sub>R antibodies. ( 29203057 )
2018
19
Paraneoplastic autoimmune encephalitis associated with pleomorphic lung carcinoma: An autopsy case report. ( 29781194 )
2018
20
NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors. ( 29949761 )
2018
21
Treatment strategies for autoimmune encephalitis. ( 29399043 )
2018
22
High albumin level is a predictor of favorable response to immunotherapy in autoimmune encephalitis. ( 29343812 )
2018
23
Autoimmune encephalitis positive for both anti-I^-aminobutyric acid B receptor and anticollapsin response-mediator protein 5 antibodies: A case report. ( 29504979 )
2018
24
An Update on the Treatment of Pediatric Autoimmune Encephalitis. ( 29780690 )
2018
25
Autoimmune encephalitis with GABA<sub>A</sub>receptor antibodies in a 10-year-old girl. ( 29245105 )
2018
26
Autoimmune encephalitis: a review of diagnosis and treatment. ( 29364393 )
2018
27
Apathy - Forme Fruste of Autoimmune Encephalitis. ( 29532325 )
2018
28
Long-Term Cognitive Outcomes in Patients with Autoimmune Encephalitis. ( 29936915 )
2018
29
P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis. ( 29973381 )
2018
30
Abnormal brain metabolism on FDG-PET/CT is a common early finding in autoimmune encephalitis. ( 28567435 )
2017
31
Application of the 2016 diagnostic approach for autoimmune encephalitis from Lancet Neurology to Chinese patients. ( 29110638 )
2017
32
Large-scale analysis of herpesviridae in epilepsy-patients with signs of autoimmune encephalitis. ( 29156319 )
2017
33
PD-1 Checkpoint Inhibitor Associated Autoimmune Encephalitis. ( 28626408 )
2017
34
Pediatric Autoimmune Encephalitis. ( 28904568 )
2017
35
Risk Factors for Intensive Care Unit Admission in Patients with Autoimmune Encephalitis. ( 28804482 )
2017
36
Hashimoto's Encephalitis: Rare Manifestation of Hypothyroidism. ( 28904921 )
2017
37
Progressive hearing loss and cerebellar ataxia in anti-Ma2-associated autoimmune encephalitis. ( 28099568 )
2017
38
Passively acquired thyroid autoantibodies from intravenous immunoglobulin in autoimmune encephalitis: Two case reports. ( 29246597 )
2017
39
Autoimmune encephalitis associated with voltage-gated potassium channels-complex and leucine-rich glioma-inactivated 1 antibodies - a national cohort study. ( 28544133 )
2017
40
Hello from the Other Side: How Autoantibodies Circumvent the Blood-Brain Barrier in Autoimmune Encephalitis. ( 28484451 )
2017
41
Autoimmune encephalitis with anti-leucine-rich glioma-inactivated 1 or anti-contactin-associated protein-like 2 antibodies (formerly called voltage-gated potassium channel-complex antibodies). ( 28248701 )
2017
42
Natural and induced immunization against CCL20 ameliorate experimental autoimmune encephalitis and may confer protection against multiple sclerosis. ( 28939272 )
2017
43
Immune checkpoint inhibitor-associated CNS autoimmuneA disorder (ICICAD)A following nivolumab treatment: AA new entity of drug-induced autoimmune encephalitis? ( 29050806 )
2017
44
Six autoantibodies associated with autoimmune encephalitis are not detectable in the cerebrospinal fluid of suicide attempters. ( 28448609 )
2017
45
Postmalaria Neurologic Syndrome-Autoimmune Encephalitis With Anti-Voltage-Gated Potassium-Channel Antibodies. ( 28505668 )
2017
46
Neuropsychiatric Manifestations of Pediatric NMDA Receptor Autoimmune Encephalitis: A Case Series From a Tertiary Care Center in India. ( 28841275 )
2017
47
Hashimoto's encephalitis associated with AMPAR2 antibodies: a case report. ( 28222692 )
2017
48
Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis. ( 28698711 )
2017
49
Susac's syndrome. A case of autoimmune encephalitis. ( 28943023 )
2017
50
Autoimmune Encephalitis: An update. ( 28457034 )
2017

Variations for Autoimmune Encephalitis

Expression for Autoimmune Encephalitis

Search GEO for disease gene expression data for Autoimmune Encephalitis.

Pathways for Autoimmune Encephalitis

Pathways related to Autoimmune Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 CNR1 CNTNAP2 HCRT
2
Show member pathways
10.64 CNR1 S1PR1
3 10.07 CNR1 FAAH

GO Terms for Autoimmune Encephalitis

Cellular components related to Autoimmune Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.26 CNTNAP2 HCRT LGI1 TRPV1
2 intrinsic component of plasma membrane GO:0031226 8.62 S1PR1 TRPV1

Biological processes related to Autoimmune Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excitatory postsynaptic potential GO:0060079 9.37 HCRT TRPV1
2 regulation of insulin secretion GO:0050796 9.32 CNR1 IFNG
3 sensory perception of pain GO:0019233 9.26 CNR1 TRPV1
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.16 IFNG TRPV1
5 temperature homeostasis GO:0001659 8.96 HCRT TRPV1
6 transmission of nerve impulse GO:0019226 8.62 CNTNAP2 S1PR1

Sources for Autoimmune Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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