MCID: ATM101
MIFTS: 42

Autoimmune Gastritis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases

Aliases & Classifications for Autoimmune Gastritis

MalaCards integrated aliases for Autoimmune Gastritis:

Name: Autoimmune Gastritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040090

Summaries for Autoimmune Gastritis

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that is located in the stomach.

MalaCards based summary : Autoimmune Gastritis is related to sarcoidosis 1 and hepatitis a. An important gene associated with Autoimmune Gastritis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Antibodies and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include t cells, thyroid and thymus, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Autoimmune Gastritis

Diseases in the Gastritis family:

Autoimmune Gastritis Viral Gastritis
Bacterial Gastritis

Diseases related to Autoimmune Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
# Related Disease Score Top Affiliating Genes
1 sarcoidosis 1 30.3 TNF IL2 IFNG
2 hepatitis a 30.2 TNF IL10 IFNG
3 allergic hypersensitivity disease 30.1 IL4 IL10 IFNG
4 autoimmune disease 29.9 TNF IL4 IL2 IL10 IFNG HLA-DQB1
5 colitis 29.6 TNF IL4 IL2 IL10 IFNG
6 inflammatory bowel disease 29.4 TNF IL4 IL2 IL10 IFNG
7 sclerosing cholangitis 29.1 TNF HLA-C HLA-B
8 systemic lupus erythematosus 28.9 TNF IL4 IL2 IL10 IFNG HLA-DQB1
9 autoimmune atrophic gastritis 11.6
10 gastritis 11.0
11 punctate inner choroidopathy 10.6 TNF IL10
12 oral tuberculosis 10.6 TNF IL2
13 multifocal choroiditis 10.6 TNF IL10
14 choroiditis 10.6 TNF IL10
15 pernicious anemia 10.6
16 virus associated hemophagocytic syndrome 10.6 IL4 IL2
17 transient hypogammaglobulinemia 10.6 TNF IL10
18 streptococcal toxic-shock syndrome 10.6 TNF IL2
19 atrophic gastritis 10.6
20 staphylococcal toxic shock syndrome 10.6 TNF IFNG
21 cow milk allergy 10.5 TNF IL10
22 autoimmune myocarditis 10.5 TNF IFNG
23 autoimmune vasculitis 10.5 IL4 IL2
24 farmer's lung 10.5 TNF IL2
25 trichuriasis 10.5 TNF IL10
26 cephalosporin allergy 10.5 IL10 IFNG
27 mucocutaneous leishmaniasis 10.5 TNF IL10
28 retinitis pigmentosa 22 10.5 IL4 IL10
29 jak3-deficient severe combined immunodeficiency 10.5 IL4 IL2
30 opisthorchiasis 10.5 TNF IL4
31 trichosporonosis 10.5 TNF IFNG
32 b-cell growth factor 10.5 IL4 IFNG
33 beryllium disease 10.5 TNF HLA-DQB1
34 iron metabolism disease 10.5
35 variola major 10.5 IL2 IFNG
36 sporotrichosis 10.5 IL10 IFNG
37 fixed drug eruption 10.5 IL2 IFNG
38 miliary tuberculosis 10.5 TNF IFNG
39 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.5
40 penicillin allergy 10.5 IL4 IFNG
41 beta-lactam allergy 10.5 IL4 IL10
42 angiostrongyliasis 10.5 IL4 IL2
43 apple allergy 10.5 IL4 IL10
44 berylliosis 10.5 IL2 IFNG
45 deficiency anemia 10.5
46 crustacean allergy 10.4 IL4 IFNG
47 tropical endomyocardial fibrosis 10.4 TNF IL4 IL10
48 endomyocardial fibrosis 10.4 TNF IL4 IL10
49 helicobacter pylori infection 10.4
50 tungiasis 10.4 TNF IL4 IL10

Graphical network of the top 20 diseases related to Autoimmune Gastritis:



Diseases related to Autoimmune Gastritis

Symptoms & Phenotypes for Autoimmune Gastritis

MGI Mouse Phenotypes related to Autoimmune Gastritis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.1 EGF EGFR HLA-DQB1 IFNG IL10 IL2
2 endocrine/exocrine gland MP:0005379 10.08 EGF EGFR HLA-DQB1 IFNG IL10 IL2
3 growth/size/body region MP:0005378 10.06 EGF EGFR HLA-DQB1 IFNG IL10 IL2
4 immune system MP:0005387 10.03 EGF EGFR HLA-DQB1 IFNG IL10 IL2
5 liver/biliary system MP:0005370 9.91 EGFR HLA-DQB1 IFNG IL10 IL2 IL4
6 integument MP:0010771 9.88 EGF EGFR IFNG IL10 IL4 TNF
7 reproductive system MP:0005389 9.76 EGF EGFR HLA-DQB1 IFNG IL10 IL2
8 no phenotypic analysis MP:0003012 9.73 EGFR IFNG IL10 IL2 IL4 TNF
9 neoplasm MP:0002006 9.72 EGFR IFNG IL10 IL2 TNF
10 respiratory system MP:0005388 9.5 EGFR HLA-DQB1 IFNG IL10 IL2 IL4
11 vision/eye MP:0005391 9.17 EGF EGFR IFNG IL10 IL2 IL4

Drugs & Therapeutics for Autoimmune Gastritis

Drugs for Autoimmune Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunologic Factors
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Levothyroxine Absorption in Morbidly Obese Patients Before and After Roux-en-Y Bariatric Surgery Completed NCT01189344 Levothyroxine
2 Prevalence of Graves Disease in Patients With Ulcerative Colitis Not yet recruiting NCT03324334

Search NIH Clinical Center for Autoimmune Gastritis

Genetic Tests for Autoimmune Gastritis

Anatomical Context for Autoimmune Gastritis

MalaCards organs/tissues related to Autoimmune Gastritis:

41
T Cells, Thyroid, Thymus, Liver, Bone, Colon, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Gastritis:

19
Stomach

Publications for Autoimmune Gastritis

Articles related to Autoimmune Gastritis:

(show top 50) (show all 475)
# Title Authors PMID Year
1
Multicenter study of autoimmune gastritis in Japan: clinical and endoscopic characteristics. 38
31368581 2019
2
Prevalence of Autoimmune Gastritis in Individuals Undergoing Medical Checkups in Japan. 38
30918182 2019
3
Autoimmune Diseases and Gastric Cancer Risk: A Systematic Review and Meta-Analysis. 38
31048663 2019
4
Anti-gastric parietal cell antibodies for autoimmune gastritis screening in juvenile autoimmune thyroid disease. 38
31264142 2019
5
High Prevalence of Autoimmune Gastritis in Patients with Nonalcoholic Steatohepatitis. 38
31292380 2019
6
Insights Into Pediatric Autoimmune Gastritis: Is There a Role for Helicobacter pylori Infection? 38
30664567 2019
7
Synchronous Early Gastric Cancer/Neuroendocrine Tumor Associated with Autoimmune Gastritis Completely Resected with Endoscopic Submucosal Dissection: A Case Report. 38
31178500 2019
8
Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk. 38
31109082 2019
9
Neurological disorders in vitamin B12 deficiency. 38
31094486 2019
10
Deficiency of micronutrients in patients affected by chronic atrophic autoimmune gastritis: A single-institution observational study. 38
30236765 2019
11
Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia. 38
30511397 2019
12
Non-malignant Helicobacter pylori-Associated Diseases. 38
31016630 2019
13
Intrinsic factor recognition promotes T helper 17/T helper 1 autoimmune gastric inflammation in patients with pernicious anemia. 38
31080562 2019
14
The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series. 38
30639646 2019
15
Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. 38
30208979 2019
16
A human mode of intestinal type gastric carcinoma. 38
30696587 2019
17
[Endoscopic treatment for gastric carcinoid tumor in a patient with type A gastritis complicated with autoimmune polyendocrine syndrome: a case report]. 38
31406070 2019
18
Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis. 38
30740042 2019
19
New Variant of MELAS Syndrome With Executive Dysfunction, Heteroplasmic Point Mutation in the MT-ND4 Gene (m.12015T>C; p.Leu419Pro) and Comorbid Polyglandular Autoimmune Syndrome Type 2. 38
30949164 2019
20
Guilt by association: intestinal metaplasia does not progress to gastric cancer. 38
30138135 2018
21
Evidence of diabetes-specific autoimmunity in obese subjects with normal glucose tolerance. 38
30129269 2018
22
Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test. 38
30502855 2018
23
Gastric Carcinoids. 38
30098721 2018
24
Pernicious anemia associated with cryptogenic cirrhosis: Two case reports and a literature review. 38
30278550 2018
25
Hemolytic Anemia and Gastric Carcinoid in a Russian Seafarer: Highlighting the Role of Diagnostic Technologies in Modern Clinical Practice. 38
30258311 2018
26
Mid- and Deep-Zone Gastritis: A Histologic Pattern Associated With Autoimmune Disease but Distinct From Autoimmune Atrophic Gastritis. 38
30032289 2018
27
High incidence of autoimmune gastritis in patients misdiagnosed with two or more failures of H. pylori eradication. 38
29920721 2018
28
Estimate of the Prevalence of Anti-Gastric Parietal Cell Autoantibodies in Healthy Individuals Is Method Dependent. 38
30007281 2018
29
MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults. 38
29490937 2018
30
A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. 38
29431870 2018
31
The Changing Face of Noncardia Gastric Cancer Incidence Among US Non-Hispanic Whites. 38
29361173 2018
32
Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases. 38
29278427 2018
33
The Relations Among Serum Ghrelin, Motilin and Gastric Emptying and Autonomic Function in Autoimmune Gastritis. 38
29753372 2018
34
Gastrointestinal complications in patients with diabetes mellitus. 38
29533548 2018
35
Utility of a laboratory score in the prediction of gastric emptying in autoimmune gastritis patients. 38
28738729 2018
36
Utility of a laboratory score in the prediction of altered autonomic nervous system function in autoimmune gastritis. 38
29391305 2018
37
Autoimmunity and Gastric Cancer. 38
29373557 2018
38
Old and New Gut Hormone, Gastrin and Acid Suppressive Therapy. 38
29587283 2018
39
Autoimmune Gastritis in the Pediatric Age: An Underestimated Condition Report of Two Cases and Review. 38
29765934 2018
40
Systematic gastric biopsy in iron deficiency anaemia. 38
29273468 2017
41
Revisiting autoimmune gastritis in children and adolescents with type 1 diabetes. 38
28004477 2017
42
Change in nomenclature for the immunologic synapse from Troxis Necrosis to trogocytosis. 38
28843649 2017
43
Multiplex autoantibody detection for autoimmune liver diseases and autoimmune gastritis. 38
28522403 2017
44
Helicobacter pylori infection and nonmalignant diseases. 38
28891136 2017
45
Tablet and oral liquid L-thyroxine formulation in the treatment of naïve hypothyroid patients with Helicobacter pylori infection. 38
27848196 2017
46
Regulation of Gastric Carcinogenesis by Inflammatory Cytokines. 38
28560288 2017
47
Differences between older and young patients with autoimmune gastritis. 38
27444719 2017
48
Helicobacter pylori and necessary rationale for autoimmune gastritis. 38
28290721 2017
49
Autoimmune gastritis: relationships with anemia and Helicobacter pylori status. 38
28276835 2017
50
Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis. 38
28290237 2017

Variations for Autoimmune Gastritis

Expression for Autoimmune Gastritis

Search GEO for disease gene expression data for Autoimmune Gastritis.

Pathways for Autoimmune Gastritis

Pathways related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 TNF IL4 IL2 IL10 IFNG HLA-DQB1
2
Show member pathways
13.49 TNF IL4 IL2 IL10 IFNG EGFR
3
Show member pathways
13.39 HLA-DQB1 HLA-C HLA-B HLA-A EGFR EGF
4
Show member pathways
13.35 TNF IL4 IL2 IL10 EGFR EGF
5
Show member pathways
13.26 TNF IL4 IL2 IL10 EGFR EGF
6
Show member pathways
13.18 TNF IL4 IL2 IFNG HLA-DQB1 EGFR
7
Show member pathways
12.95 HLA-DQB1 HLA-C HLA-B HLA-A EGFR
8
Show member pathways
12.92 TNF HLA-C HLA-B HLA-A EGFR
9 12.82 IL4 IL2 IFNG EGFR EGF
10
Show member pathways
12.81 TNF IL4 IL2 HLA-C HLA-B HLA-A
11
Show member pathways
12.81 TNF IL4 IL2 IL10 IFNG HLA-DQB1
12
Show member pathways
12.66 TNF IL2 EGFR EGF
13
Show member pathways
12.64 TNF IFNG EGFR EGF
14
Show member pathways
12.63 TNF IL4 IL2 IL10 IFNG HLA-DQB1
15
Show member pathways
12.59 TNF IL2 IL10 IFNG EGFR
16
Show member pathways
12.58 TNF IL4 IL2 IL10 IFNG
17 12.57 TNF IL4 IL2 IL10 IFNG
18
Show member pathways
12.57 TNF IL4 IL2 IL10 IFNG HLA-DQB1
19
Show member pathways
12.55 TNF IL4 IL2 IL10 IFNG HLA-DQB1
20
Show member pathways
12.54 IFNG HLA-DQB1 HLA-C HLA-B HLA-A
21 12.4 HLA-C HLA-B HLA-A EGFR
22
Show member pathways
12.38 IL4 IL2 IL10 IFNG EGFR EGF
23
Show member pathways
12.34 TNF IL4 IL2 IFNG
24
Show member pathways
12.34 TNF IL4 IL2 IFNG HLA-C HLA-B
25 12.29 TNF IL2 HLA-DQB1 HLA-C HLA-B HLA-A
26
Show member pathways
12.28 TNF IL4 IL10 IFNG HLA-DQB1
27 12.24 TNF IL10 IFNG HLA-DQB1
28 12.2 TNF IFNG EGFR EGF
29
Show member pathways
12.16 TNF IL2 IL10
30 12.16 HLA-DQB1 HLA-C HLA-B HLA-A
31
Show member pathways
12.14 TNF IL4 IFNG
32 12.13 HLA-DQB1 HLA-C HLA-B HLA-A
33 12.12 HLA-C HLA-B HLA-A
34
Show member pathways
12.08 TNF IL2 IL10 IFNG
35
Show member pathways
12.07 IL4 IL2 IL10 IFNG EGFR EGF
36
Show member pathways
12.05 IL10 EGFR EGF
37 12.05 HLA-C HLA-B HLA-A
38
Show member pathways
12.01 TNF IL4 IFNG
39
Show member pathways
12 IL4 IL2 IFNG HLA-A
40 11.99 TNF IL4 IL2 IFNG EGFR
41 11.96 TNF IL4 IL10
42 11.96 TNF IL4 IL2 IL10 IFNG
43 11.94 IFNG EGFR EGF
44 11.91 TNF IL10 IFNG
45 11.9 HLA-DQB1 EGFR EGF
46
Show member pathways
11.89 HLA-DQB1 EGFR EGF
47 11.89 TNF IL4 HLA-DQB1
48 11.89 IL2 IL10 IFNG EGFR EGF
49 11.86 TNF IFNG HLA-DQB1
50 11.81 IL4 IL2 IFNG

GO Terms for Autoimmune Gastritis

Cellular components related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.87 TNF IL4 IL2 IL10 IFNG EGFR
2 cell surface GO:0009986 9.8 TNF HLA-C HLA-B HLA-A EGFR
3 Golgi membrane GO:0000139 9.77 HLA-DQB1 HLA-C HLA-B HLA-A EGFR
4 recycling endosome membrane GO:0055038 9.63 HLA-C HLA-B HLA-A
5 phagocytic vesicle membrane GO:0030670 9.61 HLA-C HLA-B HLA-A
6 early endosome membrane GO:0031901 9.56 HLA-C HLA-B HLA-A EGFR
7 ER to Golgi transport vesicle membrane GO:0012507 9.46 HLA-DQB1 HLA-C HLA-B HLA-A
8 MHC class I protein complex GO:0042612 9.13 HLA-C HLA-B HLA-A
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.92 HLA-DQB1 HLA-C HLA-B HLA-A
10 extracellular region GO:0005576 10.02 TNF IL4 IL2 IL10 IFNG EGFR

Biological processes related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 TNF IL4 IFNG EGF
2 cytokine-mediated signaling pathway GO:0019221 9.94 TNF IL4 IL2 IL10
3 MAPK cascade GO:0000165 9.88 TNF IL2 EGFR EGF
4 regulation of immune response GO:0050776 9.87 IL4 HLA-C HLA-B HLA-A
5 positive regulation of protein kinase B signaling GO:0051897 9.86 TNF EGFR EGF
6 positive regulation of protein phosphorylation GO:0001934 9.83 TNF IL2 IFNG EGFR
7 positive regulation of inflammatory response GO:0050729 9.81 TNF IL2 EGFR
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 IL4 IL2 IFNG
9 type I interferon signaling pathway GO:0060337 9.77 HLA-C HLA-B HLA-A
10 positive regulation of MAP kinase activity GO:0043406 9.77 TNF EGFR EGF
11 positive regulation of protein localization to plasma membrane GO:1903078 9.73 TNF IFNG EGFR
12 regulation of synapse organization GO:0050807 9.69 TNF IL10
13 positive regulation of cytokine secretion GO:0050715 9.69 TNF IL10
14 positive regulation of protein complex assembly GO:0031334 9.68 TNF IFNG
15 positive regulation of osteoclast differentiation GO:0045672 9.68 TNF IFNG
16 positive regulation of T cell differentiation GO:0045582 9.68 IL4 IL2
17 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.67 EGFR EGF
18 regulation of regulatory T cell differentiation GO:0045589 9.67 IL2 IFNG
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.66 TNF IFNG
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.66 TNF IL10
21 negative regulation of growth of symbiont in host GO:0044130 9.65 TNF IL10
22 positive regulation of isotype switching to IgG isotypes GO:0048304 9.65 IL4 IL2
23 astrocyte activation GO:0048143 9.65 TNF EGFR
24 negative regulation of mitotic cell cycle GO:0045930 9.65 TNF IL10 EGFR
25 endothelial cell apoptotic process GO:0072577 9.64 TNF IL10
26 positive regulation of MHC class II biosynthetic process GO:0045348 9.63 IL4 IL10
27 negative regulation of ERBB signaling pathway GO:1901185 9.61 EGFR EGF
28 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 TNF IL10
29 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.61 HLA-C HLA-B HLA-A
30 protection from natural killer cell mediated cytotoxicity GO:0042270 9.58 HLA-B HLA-A
31 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.58 HLA-C HLA-B HLA-A
32 type 2 immune response GO:0042092 9.55 IL4 IL10
33 regulation of isotype switching GO:0045191 9.54 IL4 IL10
34 positive regulation of T cell mediated cytotoxicity GO:0001916 9.54 HLA-C HLA-B HLA-A
35 receptor biosynthetic process GO:0032800 9.51 TNF IL10
36 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.5 HLA-C HLA-B HLA-A
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 TNF IFNG
38 positive regulation of vitamin D biosynthetic process GO:0060557 9.46 TNF IFNG
39 antigen processing and presentation GO:0019882 9.46 HLA-DQB1 HLA-C HLA-B HLA-A
40 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.43 HLA-C HLA-B HLA-A
41 interferon-gamma-mediated signaling pathway GO:0060333 9.35 IFNG HLA-DQB1 HLA-C HLA-B HLA-A
42 immune response GO:0006955 9.28 TNF IL4 IL2 IL10 IFNG HLA-DQB1
43 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 TNF IL4 IL2 IL10 EGFR
44 positive regulation of transcription, DNA-templated GO:0045893 10.02 TNF IL4 IL10 EGFR EGF
45 positive regulation of cell proliferation GO:0008284 10 IL2 IFNG EGFR EGF

Molecular functions related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.62 HLA-C HLA-B HLA-A EGFR
2 growth factor activity GO:0008083 9.46 IL4 IL2 IL10 EGF
3 cytokine activity GO:0005125 9.35 TNF IL4 IL2 IL10 IFNG
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.96 EGF
5 peptide antigen binding GO:0042605 8.92 HLA-DQB1 HLA-C HLA-B HLA-A

Sources for Autoimmune Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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