MCID: ATM101
MIFTS: 45

Autoimmune Gastritis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases

Aliases & Classifications for Autoimmune Gastritis

MalaCards integrated aliases for Autoimmune Gastritis:

Name: Autoimmune Gastritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040090

Summaries for Autoimmune Gastritis

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that is located in the stomach.

MalaCards based summary : Autoimmune Gastritis is related to systemic lupus erythematosus and cholangitis. An important gene associated with Autoimmune Gastritis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Immunologic Factors and Antibodies, Antinuclear have been mentioned in the context of this disorder. Affiliated tissues include t cells, thyroid and liver, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Autoimmune Gastritis

Diseases in the Gastritis family:

Autoimmune Gastritis Viral Gastritis
Bacterial Gastritis

Diseases related to Autoimmune Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 258)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 29.9 IL10 IL2 IL4 IL6 TNF
2 cholangitis 29.7 HLA-B IL6 TNF
3 colitis 29.7 IL10 IL2 IL4 IL6 TNF
4 celiac disease 1 29.7 IL10 IL2 TNF
5 autoimmune disease 29.5 HLA-B IL10 IL2 IL4 IL6 TNF
6 autoimmune atrophic gastritis 11.2
7 gastritis 10.9
8 scleritis 10.3 IL4 TNF
9 opisthorchiasis 10.3 IL4 TNF
10 microscopic colitis 10.3 IL2 TNF
11 crohn's colitis 10.3 IL2 TNF
12 farmer's lung 10.3 IL2 TNF
13 autoimmune vasculitis 10.3 IL2 IL4
14 angiostrongyliasis 10.3 IL2 IL4
15 cow milk allergy 10.3 IL10 TNF
16 trachoma 10.3 IL10 TNF
17 trichuriasis 10.3 IL10 TNF
18 jak3-deficient severe combined immunodeficiency 10.3 IL2 IL4
19 transient hypogammaglobulinemia 10.3 IL10 TNF
20 atopic keratoconjunctivitis 10.3 IL2 IL4
21 mucocutaneous leishmaniasis 10.3 IL10 TNF
22 chronic graft versus host disease 10.3 IL10 TNF
23 idiopathic achalasia 10.3 IL10 TNF
24 retinitis pigmentosa 22 10.3 IL10 IL4
25 nickel allergic contact dermatitis 10.3 IL10 IL4
26 baylisascariasis 10.3 IL10 IL4
27 apple allergy 10.3 IL10 IL4
28 beta-lactam allergy 10.3 IL10 IL4
29 penicillin allergy 10.3 IL10 IL4
30 eosinophilic meningitis 10.3 IL10 IL4
31 filarial elephantiasis 10.3 IL10 IL4
32 retinitis pigmentosa 44 10.3 IL10 IL2
33 nontuberculous mycobacterial lung disease 10.3 HLA-B TNF
34 chronic active epstein-barr virus infection 10.3 IL10 IL2
35 soft tissue sarcoma 10.2 EGFR TNF
36 oral tuberculosis 10.2 IL2 TNF
37 iron metabolism disease 10.2
38 punctate inner choroidopathy 10.2 IL10 TNF
39 retinitis pigmentosa 55 10.2 IL6 TNF
40 juvenile ankylosing spondylitis 10.2 IL6 TNF
41 endometrial disease 10.2 IL6 TNF
42 meconium aspiration syndrome 10.2 IL6 TNF
43 louse-borne relapsing fever 10.2 IL6 TNF
44 poems syndrome 10.2 IL6 TNF
45 glossitis 10.2 IL6 TNF
46 laryngitis 10.2 IL6 TNF
47 central nervous system vasculitis 10.2 IL6 TNF
48 periapical periodontitis 10.2 IL6 TNF
49 acute vascular insufficiency of intestine 10.2 IL6 TNF
50 osteosclerotic myeloma 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Autoimmune Gastritis:



Diseases related to Autoimmune Gastritis

Symptoms & Phenotypes for Autoimmune Gastritis

MGI Mouse Phenotypes related to Autoimmune Gastritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.98 EGF EGFR IL10 IL2 IL4 IL6
2 endocrine/exocrine gland MP:0005379 9.95 EGF EGFR IL10 IL2 IL4 IL6
3 integument MP:0010771 9.85 EGF EGFR IL10 IL4 IL6 TNF
4 liver/biliary system MP:0005370 9.8 EGFR IL10 IL2 IL4 IL6 TNF
5 reproductive system MP:0005389 9.7 EGF EGFR IL10 IL2 IL4 IL6
6 neoplasm MP:0002006 9.65 EGFR IL10 IL2 IL6 TNF
7 respiratory system MP:0005388 9.43 EGFR IL10 IL2 IL4 IL6 TNF
8 vision/eye MP:0005391 9.17 EGF EGFR IL10 IL2 IL4 IL6

Drugs & Therapeutics for Autoimmune Gastritis

Drugs for Autoimmune Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors
2 Antibodies, Antinuclear
3 Immunoglobulins
4 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Autoimmune Diseases And Serum Anti-Nuclear Antibodies Positivity In Non-Celiac Wheat Sensitivity Patients Completed NCT02248545

Search NIH Clinical Center for Autoimmune Gastritis

Genetic Tests for Autoimmune Gastritis

Anatomical Context for Autoimmune Gastritis

MalaCards organs/tissues related to Autoimmune Gastritis:

41
T Cells, Thyroid, Liver, Bone, Heart, Lung, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Gastritis:

19
The Stomach

Publications for Autoimmune Gastritis

Articles related to Autoimmune Gastritis:

(show top 50) (show all 165)
# Title Authors Year
1
Utility of a laboratory score in the prediction of altered autonomic nervous system function in autoimmune gastritis. ( 29391305 )
2018
2
High incidence of autoimmune gastritis in patients misdiagnosed with two or more failures of H. pylori eradication. ( 29920721 )
2018
3
Utility of a laboratory score in the prediction of gastric emptying in autoimmune gastritis patients. ( 28738729 )
2018
4
The Relations Among Serum Ghrelin, Motilin and Gastric Emptying and Autonomic Function in Autoimmune Gastritis. ( 29753372 )
2018
5
Autoimmune Gastritis in the Pediatric Age: An Underestimated Condition Report of Two Cases and Review. ( 29765934 )
2018
6
Deficiency of micronutrients in patients affected by chronic atrophic autoimmune gastritis: A single-institution observational study. ( 30236765 )
2018
7
Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test. ( 30502855 )
2018
8
Upper gastrointestinal symptoms in autoimmune gastritis: A cross-sectional study. ( 28072728 )
2017
9
Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review. ( 28216963 )
2017
10
Autoimmune gastritis: relationships with anemia and Helicobacter pylori status. ( 28276835 )
2017
11
Helicobacter pylori and necessary rationale for autoimmune gastritis. ( 28290721 )
2017
12
Hashimoto's Thyroiditis and Autoimmune Gastritis. ( 28491051 )
2017
13
Multiplex autoantibody detection for autoimmune liver diseases and autoimmune gastritis. ( 28522403 )
2017
14
Autoimmune gastritis: assessment of OLGA and OLGIM staging systems. ( 29492930 )
2017
15
Factors associated with elevated serum chromogranin A levels in patients with autoimmune gastritis. ( 27852542 )
2016
16
Revisiting autoimmune gastritis in children and adolescents with type 1 diabetes. ( 28004477 )
2016
17
Polyautoimmunity in autoimmune gastritis. ( 27085391 )
2016
18
Relationships between autonomic nerve function and gastric emptying in patients with autoimmune gastritis. ( 27059861 )
2016
19
Differences between older and young patients with autoimmune gastritis. ( 27444719 )
2016
20
Assessment of Gastric Emptying in Patients with Autoimmune Gastritis. ( 26725066 )
2016
21
Oxyntic gastric atrophy in Helicobacter pylori gastritis is distinct from autoimmune gastritis. ( 26729016 )
2016
22
Induction of autoimmune gastritis by neonatal thymectomy requires autoantibodies and is prevented by anti-FcγR antibodies. ( 26748859 )
2016
23
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis. ( 27259856 )
2016
24
Autoimmune gastritis. ( 27671008 )
2016
25
Malignant transformation of a gastric hyperplastic polyp in a context of Helicobacter pylori-negative autoimmune gastritis: a case report. ( 27729029 )
2016
26
Autoimmune gastritis: Pathologist's viewpoint. ( 26576102 )
2015
27
Diminished salivary epidermal growth factor secretion: a link between SjAPgren's syndrome and autoimmune gastritis? ( 26399281 )
2015
28
Autoimmune gastritis in autoimmune thyroid disease. ( 25648057 )
2015
29
Single nucleotide polymorphisms related to vitamin B12 serum levels in autoimmune gastritis patients with or without pernicious anaemia. ( 25681243 )
2015
30
Autoimmune gastritis among T1D individuals - important association? ( 27776198 )
2015
31
Mean platelet volume and red cell distribution width in autoimmune gastritis: Confounding factors should be considered. ( 24433174 )
2014
32
Autoimmune gastritis presenting as iron deficiency anemia in childhood. ( 25400463 )
2014
33
Diagnosis and classification of autoimmune gastritis. ( 24424193 )
2014
34
Dominant trait linked to chromosome 1 in DBA/2 mice for the resistance to autoimmune gastritis appears in bone marrow cells. ( 24770641 )
2014
35
A case of rheumatic valvular heart disease and autoimmune gastritis. ( 25535234 )
2014
36
Interleukin-21 and tumor necrosis factor-I+ are critical for the development of autoimmune gastritis in mice. ( 23425147 )
2013
37
Hepatitis C virus antibody positivity may not be associated with hepatitis C infection in patients with autoimmune gastritis. ( 23011039 )
2013
38
Are patients with autoimmune thyroid disease and autoimmune gastritis at risk for Gastric Neuroendocrine Tumours type 1? ( 24118101 )
2013
39
The predictive value of mean platelet volume, plateletcrit and red cell distribution width in the differentiation of autoimmune gastritis patients with and without type I gastric carcinoid tumors. ( 24175991 )
2013
40
Autoimmune gastritis: novel clues to histological diagnosis. ( 23277173 )
2013
41
Autoimmune gastritis mediated by CD4+ T cells promotes the development of gastric cancer. ( 23378345 )
2013
42
Features of the atrophic corpus mucosa in three cases of autoimmune gastritis revealed by magnifying endoscopy. ( 22811721 )
2012
43
Clinical profiles, endoscopic and laboratory features and associated factors in patients with autoimmune gastritis. ( 22710370 )
2012
44
Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice. ( 22124119 )
2012
45
Effect of endogenous hypergastrinemia on gallbladder volume and ejection fraction in patients with autoimmune gastritis. ( 23060399 )
2012
46
Clinical usefulness of the serological gastric biopsy for the diagnosis of chronic autoimmune gastritis. ( 23251219 )
2012
47
Both IFN-I^ and IL-17 are required for the development of severe autoimmune gastritis. ( 22777705 )
2012
48
Cutting edge issues in autoimmune gastritis. ( 21174235 )
2012
49
Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice. ( 21921286 )
2012
50
Successful endoscopic submucosal dissection of gastric carcinoid in a patient with autoimmune gastritis and systemic lupus erythematosus. ( 22687792 )
2012

Variations for Autoimmune Gastritis

Expression for Autoimmune Gastritis

Search GEO for disease gene expression data for Autoimmune Gastritis.

Pathways for Autoimmune Gastritis

Pathways related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 EGF EGFR HLA-B IL10 IL2 IL4
2
Show member pathways
13.76 EGF EGFR IL10 IL2 IL4 IL6
3
Show member pathways
13.47 EGF EGFR IL10 IL2 IL4 IL6
4
Show member pathways
13.34 EGF EGFR IL10 IL2 IL4 IL6
5
Show member pathways
13.25 EGF EGFR HLA-B IL10 IL2 IL4
6
Show member pathways
13.21 EGF EGFR IL10 IL2 IL4 IL6
7
Show member pathways
13.2 EGF EGFR IL2 IL6 TNF
8
Show member pathways
13.13 EGF EGFR IL2 IL4 TNF
9
Show member pathways
13 EGF EGFR IL2 IL4 IL6
10
Show member pathways
12.86 EGF EGFR HLA-B IL2 IL4 IL6
11 12.8 EGF EGFR IL2 IL4 IL6
12
Show member pathways
12.76 HLA-B IL2 IL4 IL6 TNF
13
Show member pathways
12.71 IL2 IL4 IL6 TNF
14
Show member pathways
12.68 EGF EGFR IL2 IL6 TNF
15
Show member pathways
12.58 IL10 IL2 IL4 TNF
16
Show member pathways
12.56 IL10 IL2 IL4 IL6 TNF
17
Show member pathways
12.55 EGFR IL10 IL2 IL6 TNF
18 12.53 IL10 IL2 IL4 TNF
19
Show member pathways
12.47 HLA-B IL2 IL4 KIR3DL2 TNF
20 12.41 HLA-B IL2 IL6 TNF
21
Show member pathways
12.39 IL10 IL2 IL4 IL6 TNF
22
Show member pathways
12.33 EGF EGFR IL2 IL6
23
Show member pathways
12.32 IL2 IL4 IL6 TNF
24
Show member pathways
12.3 HLA-B IL10 IL2 IL4 IL6 KIR3DL2
25
Show member pathways
12.28 EGF EGFR IL10 IL2 IL4 IL6
26
Show member pathways
12.2 IL10 IL4 TNF
27
Show member pathways
12.2 IL10 IL2 IL6 TNF
28 12.18 EGF EGFR IL6 TNF
29 12.17 IL10 IL6 TNF
30
Show member pathways
12.16 EGFR IL6 TNF
31
Show member pathways
12.13 IL4 IL6 TNF
32 12.13 IL10 IL6 TNF
33
Show member pathways
12.08 EGF EGFR IL10 IL6
34
Show member pathways
12.07 EGF EGFR IL6
35
Show member pathways
12.05 IL10 IL2 IL6 TNF
36 12.03 HLA-B KIR3DL2 KIR3DS1
37 12.02 EGF EGFR TNF
38
Show member pathways
12 IL4 IL6 TNF
39
Show member pathways
11.98 EGF EGFR IL10 IL2 IL4 IL6
40 11.97 IL10 IL4 IL6 TNF
41
Show member pathways
11.91 EGFR HLA-B IL10 IL2 IL4 IL6
42 11.89 EGF EGFR IL6
43 11.88 IL4 IL6 TNF
44 11.88 EGFR IL2 IL4 IL6 TNF
45 11.87 IL10 IL6 TNF
46 11.83 IL10 IL2 IL4 IL6 TNF
47 11.8 EGF EGFR IL10 IL2 IL6
48 11.79 IL2 IL4 IL6
49 11.78 IL10 IL2 IL4 TNF
50
Show member pathways
11.76 IL2 IL4 TNF

GO Terms for Autoimmune Gastritis

Cellular components related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 EGF EGFR IL10 IL2 IL4 IL6
2 extracellular space GO:0005615 9.17 EGF EGFR IL10 IL2 IL4 IL6

Biological processes related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.95 EGF IL4 IL6 TNF
2 negative regulation of apoptotic process GO:0043066 9.92 EGFR IL10 IL2 IL4 IL6
3 positive regulation of protein phosphorylation GO:0001934 9.85 EGFR IL2 TNF
4 positive regulation of protein kinase B signaling GO:0051897 9.85 EGF EGFR TNF
5 cellular response to lipopolysaccharide GO:0071222 9.85 IL10 IL6 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 IL10 IL6 TNF
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 EGFR IL6 TNF
8 MAPK cascade GO:0000165 9.78 EGF EGFR IL2 TNF
9 positive regulation of inflammatory response GO:0050729 9.77 EGFR IL2 TNF
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.76 IL2 IL4 IL6
11 response to glucocorticoid GO:0051384 9.72 IL10 IL6 TNF
12 regulation of signaling receptor activity GO:0010469 9.72 IL10 IL2 IL4 IL6 TNF
13 positive regulation of MAP kinase activity GO:0043406 9.69 EGF EGFR TNF
14 negative regulation of neurogenesis GO:0050768 9.68 IL6 TNF
15 positive regulation of chemokine production GO:0032722 9.67 IL6 TNF
16 positive regulation of T cell proliferation GO:0042102 9.67 IL2 IL4 IL6
17 positive regulation of T cell differentiation GO:0045582 9.66 IL2 IL4
18 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.66 EGF EGFR
19 positive regulation of glial cell proliferation GO:0060252 9.65 IL6 TNF
20 negative regulation of growth of symbiont in host GO:0044130 9.65 IL10 TNF
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 IL10 TNF
22 positive regulation of immunoglobulin secretion GO:0051024 9.63 IL2 IL6
23 astrocyte activation GO:0048143 9.63 EGFR TNF
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.63 EGFR IL6 TNF
25 positive regulation of transcription, DNA-templated GO:0045893 9.63 EGF EGFR IL10 IL4 IL6 TNF
26 positive regulation of isotype switching to IgG isotypes GO:0048304 9.62 IL2 IL4
27 negative regulation of lipid storage GO:0010888 9.62 IL6 TNF
28 endothelial cell apoptotic process GO:0072577 9.61 IL10 TNF
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.59 IL10 IL4
30 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 IL10 TNF
31 negative regulation of ERBB signaling pathway GO:1901185 9.57 EGF EGFR
32 positive regulation of neuroinflammatory response GO:0150078 9.56 IL6 TNF
33 regulation of isotype switching GO:0045191 9.43 IL10 IL4
34 negative regulation of mitotic cell cycle GO:0045930 9.43 EGFR IL10 TNF
35 type 2 immune response GO:0042092 9.4 IL10 IL4
36 receptor biosynthetic process GO:0032800 9.37 IL10 TNF
37 cytokine-mediated signaling pathway GO:0019221 9.35 IL10 IL2 IL4 IL6 TNF
38 immune response GO:0006955 9.17 HLA-B IL10 IL2 IL4 IL6 KIR3DS1
39 positive regulation of transcription by RNA polymerase II GO:0045944 10.01 EGFR IL10 IL2 IL4 IL6 TNF

Molecular functions related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.35 IL10 IL2 IL4 IL6 TNF
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 EGF EGFR IL2
3 growth factor activity GO:0008083 9.02 EGF IL10 IL2 IL4 IL6

Sources for Autoimmune Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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