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MCID: ATM101
MIFTS: 43

Autoimmune Gastritis

Categories: Gastrointestinal diseases, Immune diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Autoimmune Gastritis

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MalaCards integrated aliases for Autoimmune Gastritis:

Name: Autoimmune Gastritis 12 15

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Immune diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040090
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Summaries for Autoimmune Gastritis

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Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that is located in the stomach.

MalaCards based summary : Autoimmune Gastritis is related to helicobacter pylori infection and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Autoimmune Gastritis is GAST (Gastrin), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Immunologic Factors and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include stomach, t cells and thyroid, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Autoimmune Gastritis

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Diseases in the Gastritis family:

Autoimmune Gastritis Viral Gastritis
Bacterial Gastritis

Diseases related to Autoimmune Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 736)
# Related Disease Score Top Affiliating Genes
1 helicobacter pylori infection 31.1 IL1B GAST EGFR
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.0 IL10 IFNG FOXP3
3 gastritis 30.6 TNF IL6 IL1B IL10 GAST CCR6
4 atrophic gastritis 30.5 TNF IL6 IL1B IL10 HLA-DRB1 GAST
5 thyroiditis 30.3 TNF IL6 IL4 IL2 IL10 FOXP3
6 interstitial cystitis 30.2 IL6 IL2 EGF
7 cholera 30.0 TNF IL6 IL4 EGF
8 hepatitis a 30.0 TNF IL4 IL2 IL10 IFNG
9 ileitis 30.0 TNF IL6 IL10 CCR6
10 graves' disease 29.9 IL4 IFNG HLA-DRB1 HLA-B HLA-A
11 cystitis 29.9 TNF IL6 IL4 IL2 EGF
12 gastric ulcer 29.9 TNF IL6 IL1B GAST EGF
13 diphtheria 29.9 TNF IL4 IL2 IFNG EGF
14 gastric neuroendocrine neoplasm 29.9 GAST CBLIF
15 thrombocytopenia due to platelet alloimmunization 29.8 IL10 CD4 CCR6
16 autoimmune polyendocrine syndrome 29.8 IL1B IL10 FOXP3 CCR6
17 cholangitis 29.8 TNF IL6 IL2 IL10 HLA-DRB1 HLA-B
18 autoimmune hepatitis 29.7 TNF IL4 IL10 HLA-DRB1 HLA-A FOXP3
19 anemia, autoimmune hemolytic 29.7 IL2 FOXP3 CD4
20 sclerosing cholangitis 29.6 TNF IL6 IL2 IL10 HLA-DRB1 HLA-B
21 vitamin b12 deficiency 29.6 GAST CBLIF ATP4A ATP12A
22 pernicious anemia 29.5 GAST CCR6 CBLIF ATP4A ATP12A
23 vitiligo-associated multiple autoimmune disease susceptibility 1 29.5 IL2 HLA-B CD4 CCR6
24 duodenal ulcer 29.4 TNF IL6 IL1B IL10 HLA-DRB1 GAST
25 zollinger-ellison syndrome 29.4 GAST EGF ATP4A ATP12A
26 microinvasive gastric cancer 29.2 GAST ATP4A ATP12A
27 lymphopenia 29.1 IL6 IL4 IL2 IL10 IFNG FOXP3
28 orchitis 29.1 TNF IL6 IL2 IL10 FOXP3 CD4
29 cholangitis, primary sclerosing 28.9 TNF IL6 HLA-C HLA-A CD4 CCR6
30 hashimoto thyroiditis 28.9 TNF IL6 IL4 IL2 IL1B IL10
31 duodenitis 28.8 GAST CD4 ATP4A ATP12A
32 sarcoidosis 1 28.7 TNF IL2 IL1B IFNG HLA-DRB1 HLA-A
33 gastric adenocarcinoma 28.6 TNF IL6 IL1B IFNG HLA-DRB1 GAST
34 diarrhea 28.6 TNF IL6 IL2 IL1B IL10 IFNG
35 autoimmune disease 28.6 TNF IL6 IL4 IL2 IL1B IL10
36 deficiency anemia 28.5 TNF IL6 HLA-B FOXP3 CBLIF ATP4A
37 lymphoma, mucosa-associated lymphoid type 28.4 CD4 CCR6 ATP4A ATP12A
38 allergic hypersensitivity disease 28.4 TNF IL4 IL2 IL10 IFNG FOXP3
39 colitis 28.3 TNF IL6 IL4 IL2 IL1B IL10
40 systemic lupus erythematosus 27.6 TNF IL6 IL4 IL2 IL1B IL10
41 primary biliary cirrhosis 27.5 TNF IL6 IL4 IL2 IL1B IL10
42 inflammatory bowel disease 27.0 TNF IL6 IL4 IL2 IL1B IL10
43 celiac disease 1 24.7 TNF IL6 IL4 IL2 IL10 IFNG
44 autoimmune atrophic gastritis 11.6
45 punctate inner choroidopathy 10.6 TNF IL10
46 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.6 IL4 IL2
47 beryllium disease 10.6 TNF HLA-DRB1
48 external pathological resorption 10.6 TNF IL6
49 scorpion envenomation 10.6 TNF IL6
50 multifocal choroiditis 10.5 TNF IL10

Graphical network of the top 20 diseases related to Autoimmune Gastritis:



Diseases related to Autoimmune Gastritis
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Symptoms & Phenotypes for Autoimmune Gastritis

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GenomeRNAi Phenotypes related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.15 HLA-A HLA-B HLA-C
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.15 HLA-A HLA-B HLA-C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 10.15 HLA-A HLA-B HLA-C EGFR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 10.15 EGFR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.15 HLA-C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 10.15 HLA-C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-162 10.15 HLA-C
8 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.15 HLA-A HLA-B HLA-C
9 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.15 HLA-A HLA-B HLA-C
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.15 EGFR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 10.15 HLA-C
12 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.15 EGFR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.15 EGFR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-31 10.15 HLA-A HLA-B HLA-C
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.15 EGFR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.15 HLA-C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.15 HLA-A HLA-B HLA-C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.15 HLA-A HLA-B HLA-C
19 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.15 EGFR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.15 HLA-C

MGI Mouse Phenotypes related to Autoimmune Gastritis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.32 ATP12A ATP4A CD4 EGF EGFR FOXP3
2 homeostasis/metabolism MP:0005376 10.31 ATP12A ATP4A CBLIF CCR6 CD4 EGFR
3 growth/size/body region MP:0005378 10.29 ATP12A CBLIF CD4 EGF EGFR FOXP3
4 immune system MP:0005387 10.28 ATP4A CBLIF CCR6 CD4 EGF EGFR
5 endocrine/exocrine gland MP:0005379 10.27 ATP4A CD4 EGF EGFR FOXP3 GAST
6 hematopoietic system MP:0005397 10.27 ATP4A CBLIF CCR6 CD4 EGFR FOXP3
7 integument MP:0010771 10.07 CD4 EGF EGFR FOXP3 IFNG IL10
8 liver/biliary system MP:0005370 9.97 CBLIF EGFR FOXP3 IFNG IL10 IL2
9 neoplasm MP:0002006 9.91 ATP4A EGFR GAST IFNG IL10 IL1B
10 no phenotypic analysis MP:0003012 9.76 CD4 EGFR FOXP3 IFNG IL10 IL2
11 respiratory system MP:0005388 9.56 EGFR FOXP3 IFNG IL10 IL2 IL4
12 vision/eye MP:0005391 9.28 EGF EGFR FOXP3 IFNG IL10 IL2
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Drugs & Therapeutics for Autoimmune Gastritis

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Drugs for Autoimmune Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors
2 Antibodies
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevalence of Graves Disease in Patients With Ulcerative Colitis Unknown status NCT03324334
2 Levothyroxine Absorption in Morbidly Obese Patients Before and After Roux-en-Y Bariatric Surgery Completed NCT01189344 Levothyroxine

Search NIH Clinical Center for Autoimmune Gastritis

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Genetic Tests for Autoimmune Gastritis

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Anatomical Context for Autoimmune Gastritis

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The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Gastritis:

19
Stomach

MalaCards organs/tissues related to Autoimmune Gastritis:

40
T Cells, Thyroid, Bone, Liver, Lung, B Cells, Thymus
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Publications for Autoimmune Gastritis

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Articles related to Autoimmune Gastritis:

(show top 50) (show all 493)
# Title Authors PMID Year
1
Autoimmune Gastritis in Pediatrics: A Review of 3 Cases. 61
31978028 2020
2
Previous Helicobacter pylori infection-induced atrophic gastritis: A distinct disease entity in an understudied population without a history of eradication. 61
31680399 2020
3
Prevalence of gastrointestinal disorders having an impact on tablet levothyroxine absorption: should this formulation still be considered as the first-line therapy? 61
31953721 2020
4
A Rare Combination of Gastric Mucosa-associated Lymphoid Tissue Lymphoma, Autoimmune Gastritis, Thyroiditis, Hemolysis, and Systemic Lupus Erythematosus. 61
31902909 2020
5
Anti-gastric parietal cell antibodies for autoimmune gastritis screening in juvenile autoimmune thyroid disease. 61
31264142 2020
6
Thyro-entero-gastric autoimmunity: Pathophysiology and implications for patient management. 61
31864909 2019
7
Serologic Profile of Antiparietal Cell Antibodies, Pepsinogens, and H. pylori and Risk of Upper Gastrointestinal Cancer: A Nested Case-Control Study in China. 61
31501152 2019
8
Thiol/Disulphide Homeostasis and Ischemia Modified Albumin Levels in Autoimmune Gastritis and Their Relations with Gastric Emptying. 61
31814373 2019
9
Serum chromogranin A level continuously rises with the progression of type 1 diabetes, and indicates the presence of both enterochromaffin-like cell hyperplasia and autoimmune gastritis. 61
31883432 2019
10
Functional Dyspepsia in the Elderly. 61
31720909 2019
11
Next-generation sequencing identifies 2 genomically distinct groups among pyloric gland adenomas. 61
31783043 2019
12
Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients. 61
31787690 2019
13
Autoimmune Gastritis. 61
31661309 2019
14
[Chronic autoimmune gastritis : a multidisciplinary management]. 61
31729849 2019
15
Autoimmune Gastritis in Pediatrics: A review of 3 cases. 61
31688697 2019
16
High Prevalence of Autoimmune Gastritis in Patients with Nonalcoholic Steatohepatitis. 61
31292380 2019
17
Role of Autoimmune Gastritis in Gastric Cancer. 61
31517647 2019
18
Synchronous Early Gastric Cancer/Neuroendocrine Tumor Associated with Autoimmune Gastritis Completely Resected with Endoscopic Submucosal Dissection. 61
31178500 2019
19
Endoscopy opens the door to a new era of autoimmune gastritis research. 61
31545537 2019
20
Multicenter study of autoimmune gastritis in Japan: Clinical and endoscopic characteristics. 61
31368581 2019
21
Prevalence of Autoimmune Gastritis in Individuals Undergoing Medical Checkups in Japan. 61
30918182 2019
22
Autoimmune Diseases and Gastric Cancer Risk: A Systematic Review and Meta-Analysis. 61
31048663 2019
23
Insights Into Pediatric Autoimmune Gastritis: Is There a Role for Helicobacter pylori Infection? 61
30664567 2019
24
Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk. 61
31109082 2019
25
Neurological disorders in vitamin B12 deficiency. 61
31094486 2019
26
Deficiency of micronutrients in patients affected by chronic atrophic autoimmune gastritis: A single-institution observational study. 61
30236765 2019
27
Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia. 61
30511397 2019
28
Intrinsic factor recognition promotes T helper 17/T helper 1 autoimmune gastric inflammation in patients with pernicious anemia. 61
31080562 2019
29
The association of other autoimmune diseases in patients with Graves' disease (with or without ophthalmopathy): Review of the literature and report of a large series. 61
30639646 2019
30
Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. 61
30208979 2019
31
A human mode of intestinal type gastric carcinoma. 61
30696587 2019
32
Immunomodulatory Effects of Genetic Alterations Affecting the Kynurenine Pathway. 61
31781097 2019
33
[Endoscopic treatment for gastric carcinoid tumor in a patient with type A gastritis complicated with autoimmune polyendocrine syndrome: a case report]. 61
31406070 2019
34
[Gastric neuroendocrine tumors]. 61
31825351 2019
35
Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis. 61
30740042 2019
36
New Variant of MELAS Syndrome With Executive Dysfunction, Heteroplasmic Point Mutation in the MT-ND4 Gene (m.12015T>C; p.Leu419Pro) and Comorbid Polyglandular Autoimmune Syndrome Type 2. 61
30949164 2019
37
Non-malignant Helicobacter pylori-Associated Diseases. 61
31016630 2019
38
Guilt by association: intestinal metaplasia does not progress to gastric cancer. 61
30138135 2018
39
Evidence of diabetes-specific autoimmunity in obese subjects with normal glucose tolerance. 61
30129269 2018
40
Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test. 61
30502855 2018
41
Gastric Carcinoids. 61
30098721 2018
42
Pernicious anemia associated with cryptogenic cirrhosis: Two case reports and a literature review. 61
30278550 2018
43
Hemolytic Anemia and Gastric Carcinoid in a Russian Seafarer: Highlighting the Role of Diagnostic Technologies in Modern Clinical Practice. 61
30258311 2018
44
Mid- and Deep-Zone Gastritis: A Histologic Pattern Associated With Autoimmune Disease but Distinct From Autoimmune Atrophic Gastritis. 61
30032289 2018
45
Estimate of the Prevalence of Anti-Gastric Parietal Cell Autoantibodies in Healthy Individuals Is Method Dependent. 61
30007281 2018
46
High incidence of autoimmune gastritis in patients misdiagnosed with two or more failures of H. pylori eradication. 61
29920721 2018
47
A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. 61
29431870 2018
48
MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults. 61
29490937 2018
49
The Changing Face of Noncardia Gastric Cancer Incidence Among US Non-Hispanic Whites. 61
29361173 2018
50
The Relations Among Serum Ghrelin, Motilin and Gastric Emptying and Autonomic Function in Autoimmune Gastritis. 61
29753372 2018
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Variations for Autoimmune Gastritis

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Expression for Autoimmune Gastritis

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Search GEO for disease gene expression data for Autoimmune Gastritis.
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Pathways for Autoimmune Gastritis

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Pathways related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.13 TNF IL6 IL4 IL2 IL1B IL10
2
ERK Signaling 63
Show member pathways
 13.92 TNF IL6 IL4 IL2 IL1B IL10
3
PEDF Induced Signaling 63
Show member pathways
 13.78 TNF IL6 IL4 IL2 IL1B IL10
4
TGF-Beta Pathway 63
Show member pathways
 13.66 TNF IL6 IL4 IL2 IL1B IL10
5
Akt Signaling 63
Show member pathways
 13.55 TNF IL6 IL4 IL2 IL1B IL10
6
PAK Pathway 63
Show member pathways
 13.44 TNF IL6 IL4 IL2 IL1B IL10
7
IL-2 Pathway 63
Show member pathways
 13.33 TNF IL4 IL2 IL1B IFNG HLA-DRB1
8
Cytokine Signaling in Immune system 65
Show member pathways
 13.28 TNF IL6 IL4 IL2 IL1B IL10
9
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.25 TNF IL6 IL2 IL1B IL10 IFNG
10
PI3K-Akt signaling pathway 36
Show member pathways
 13.12 TNF IL6 IL4 IL2 HLA-C HLA-B
11
Human cytomegalovirus infection 36
Show member pathways
 13.09 TNF IL6 IL1B HLA-C HLA-B HLA-A
12
Pathways in cancer 36
12.95 IL6 IL4 IL2 IFNG EGFR EGF
13
Herpes simplex virus 1 infection 36
12.94 TNF IL6 IL1B IFNG HLA-DRB1 HLA-C
14
Measles 36
Show member pathways
 12.94 TNF IL6 IL2 IL1B IFNG HLA-DRB1
15
NF-KappaB Family Pathway 63
Show member pathways
 12.83 TNF IL6 IL2 IL1B EGFR EGF
16
4-1BB Pathway 63
Show member pathways
 12.8 TNF IL1B IFNG EGFR EGF CD4
17
Immune response NFAT in immune response 22
Show member pathways
 12.8 TNF IL4 IL2 IL10 IFNG HLA-DRB1
18
Immune response IL-23 signaling pathway 22
Show member pathways
 12.73 TNF IL6 IL2 IL1B IL10 IFNG
19
NF-kappaB Signaling 4
12.72 TNF IL4 IL2 IL1B IL10 IFNG
20
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.67 TNF IL4 IL2 IFNG HLA-C HLA-B
21
Interferon gamma signaling 65
Show member pathways
 12.64 IFNG HLA-DRB1 HLA-C HLA-B HLA-A
22
T cell receptor signaling pathway 36
Show member pathways
 12.64 TNF IL6 IL4 IL2 IL1B IL10
23
Th17 cell differentiation 36
Show member pathways
 12.6 TNF IL6 IL4 IL2 IL1B IL10
24
Folate Metabolism 1
Show member pathways
 12.48 TNF IL6 IL4 IL2 IL1B IFNG
25
IL-17 Family Signaling Pathways 64
Show member pathways
 12.47 TNF IL6 IL4 IL1B IFNG
26
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.47 TNF IL6 IL2 IL10 CCR6
27
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 12.47 IL6 IL4 IL2 IL10 IFNG EGFR
28
Human T-cell leukemia virus 1 infection 36
12.47 TNF IL6 IL2 HLA-DRB1 HLA-C HLA-B
29
Toxoplasmosis 36
Show member pathways
 12.44 TNF IL4 IL1B IL10 IFNG HLA-DRB1
30
Tuberculosis 36
12.4 TNF IL6 IL1B IL10 IFNG HLA-DRB1
31
C-type lectin receptor signaling pathway 36
Show member pathways
 12.36 TNF IL6 IL2 IL1B IL10
32
Colorectal Cancer Metastasis 63
12.34 TNF IL6 IFNG EGFR EGF
33
Bacterial infections in CF airways 22
Show member pathways
 12.33 TNF IL6 IL4 IL1B IFNG
34
IL-1 Family Signaling Pathways 64
Show member pathways
 12.31 TNF IL6 IL1B EGFR
35
Cell adhesion molecules (CAMs) 36
12.28 HLA-DRB1 HLA-C HLA-B HLA-A CD4
36
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.27 TNF IL6 IL1B IL10
37
Cellular senescence (KEGG) 36
12.26 IL6 HLA-C HLA-B HLA-A
38
Phagosome 36
12.24 HLA-DRB1 HLA-C HLA-B HLA-A
39
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 12.21 TNF IL6 IL4 IL1B IFNG
40
Th1 Differentiation Pathway 64
Show member pathways
 12.21 TNF IL6 IL2 IL1B IL10 IFNG
41
FoxO signaling pathway 36
Show member pathways
 12.19 IL6 IL10 EGFR EGF
42
Yersinia infection 36
12.18 TNF IL6 IL2 IL1B IL10
43
Allograft rejection 1 36
Show member pathways
 12.18 TNF IL6 IL4 IL2 IL1B IL10
44
Interleukin-4 and 13 signaling 65
12.16 TNF IL6 IL4 IL1B IL10
45
Spinal Cord Injury 1
12.16 TNF IL6 IL4 IL2 IL1B IFNG
46
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.12 TNF IL6 IL4 IL2 IL10 IFNG
47
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.11 TNF IL6 IL4 IL2 IL1B IL10
48
Amoebiasis 36
12.1 TNF IL6 IL1B IL10 IFNG
49
IL12-mediated signaling events 1
Show member pathways
 12.09 IL4 IL2 IL1B IFNG HLA-DRB1 HLA-A
50
HIF-1 signaling pathway 36
12.08 IL6 IFNG EGFR EGF
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GO Terms for Autoimmune Gastritis

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Cellular components related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.11 TNF IL6 IL4 IL2 IL1B IL10
2 external side of plasma membrane GO:0009897 9.83 TNF HLA-DRB1 HLA-B CD4 CCR6
3 cell surface GO:0009986 9.76 TNF HLA-DRB1 HLA-C HLA-B HLA-A EGFR
4 early endosome membrane GO:0031901 9.71 HLA-C HLA-B HLA-A EGFR
5 phagocytic vesicle membrane GO:0030670 9.65 HLA-C HLA-B HLA-A
6 clathrin-coated vesicle membrane GO:0030665 9.63 EGFR EGF CD4
7 ER to Golgi transport vesicle membrane GO:0012507 9.62 HLA-DRB1 HLA-C HLA-B HLA-A
8 extracellular space GO:0005615 9.44 TNF IL6 IL4 IL2 IL1B IL10
9 MHC class I protein complex GO:0042612 9.43 HLA-C HLA-B HLA-A
10 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DRB1 HLA-C HLA-B HLA-A

Biological processes related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.36 IL6 IL4 IL1B IL10 GAST EGFR
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.22 TNF IL6 IL4 IL2 IL1B IL10
3 immune system process GO:0002376 10.18 IL2 HLA-DRB1 HLA-C HLA-B HLA-A CD4
4 positive regulation of cell proliferation GO:0008284 10.13 IL6 IL2 IL1B IFNG EGFR EGF
5 regulation of immune response GO:0050776 10.04 IL4 HLA-C HLA-B HLA-A
6 positive regulation of gene expression GO:0010628 10.04 TNF IL6 IL4 IL1B IFNG FOXP3
7 cellular response to lipopolysaccharide GO:0071222 10.02 TNF IL6 IL1B IL10
8 MAPK cascade GO:0000165 10.02 TNF IL2 IL1B EGFR EGF
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.94 TNF IL6 IL1B IL10
10 positive regulation of protein phosphorylation GO:0001934 9.93 TNF IL2 IL1B IFNG EGFR CD4
11 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.91 HLA-C HLA-B HLA-A
12 regulation of insulin secretion GO:0050796 9.91 TNF IL1B IFNG
13 type I interferon signaling pathway GO:0060337 9.91 HLA-C HLA-B HLA-A
14 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL10
15 positive regulation of MAP kinase activity GO:0043406 9.9 TNF EGFR EGF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.9 TNF IL1B EGFR
17 positive regulation of interleukin-6 production GO:0032755 9.9 TNF IL6 IL1B
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 TNF IL6 EGFR
19 positive regulation of inflammatory response GO:0050729 9.9 TNF IL2 IL1B EGFR
20 positive regulation of protein localization to plasma membrane GO:1903078 9.88 TNF IFNG EGFR
21 T cell activation GO:0042110 9.87 IL4 FOXP3 CD4
22 cytokine-mediated signaling pathway GO:0019221 9.87 TNF IL6 IL4 IL2 IL1B IL10
23 positive regulation of phagocytosis GO:0050766 9.86 TNF IL1B IFNG
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 TNF IL1B IFNG
25 negative regulation of T cell proliferation GO:0042130 9.86 IL10 HLA-DRB1 FOXP3
26 positive regulation of interferon-gamma production GO:0032729 9.85 TNF IL2 IL1B
27 humoral immune response GO:0006959 9.85 TNF IL6 IFNG CCR6
28 negative regulation of mitotic cell cycle GO:0045930 9.84 TNF IL10 EGFR
29 negative regulation of interleukin-6 production GO:0032715 9.83 TNF IL10 FOXP3
30 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 TNF IL6 IL4 IL2 IFNG
31 negative regulation of interferon-gamma production GO:0032689 9.82 IL10 HLA-DRB1 FOXP3
32 positive regulation of JAK-STAT cascade GO:0046427 9.82 TNF IL6 IL10
33 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.81 HLA-C HLA-B HLA-A
34 negative regulation of neurogenesis GO:0050768 9.8 TNF IL6 IL1B
35 interferon-gamma-mediated signaling pathway GO:0060333 9.8 IFNG HLA-DRB1 HLA-C HLA-B HLA-A
36 antigen processing and presentation GO:0019882 9.78 HLA-DRB1 HLA-C HLA-B HLA-A
37 positive regulation of glial cell proliferation GO:0060252 9.77 TNF IL6 IL1B
38 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.76 TNF IL1B IFNG
39 regulation of regulatory T cell differentiation GO:0045589 9.75 IL2 IFNG FOXP3
40 negative regulation of amyloid-beta clearance GO:1900222 9.74 TNF IFNG
41 positive regulation of isotype switching to IgG isotypes GO:0048304 9.74 IL4 IL2
42 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.74 IL4 IL10
43 negative regulation of lipid storage GO:0010888 9.74 TNF IL6
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.74 TNF IL1B IL10
45 negative regulation of T-helper 17 cell differentiation GO:2000320 9.73 IL2 FOXP3
46 endothelial cell apoptotic process GO:0072577 9.73 TNF IL10
47 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF IL6 IL1B
48 regulation of establishment of endothelial barrier GO:1903140 9.72 TNF IL1B
49 negative regulation of ERBB signaling pathway GO:1901185 9.71 EGFR EGF
50 negative regulation of lymphocyte proliferation GO:0050672 9.71 IL2 FOXP3

Molecular functions related to Autoimmune Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.55 IL6 IL4 IL2 IL10 EGF
2 virus receptor activity GO:0001618 9.54 HLA-DRB1 EGFR CD4
3 potassium-transporting ATPase activity GO:0008556 9.32 ATP4A ATP12A
4 potassium:proton exchanging ATPase activity GO:0008900 9.26 ATP4A ATP12A
5 peptide antigen binding GO:0042605 9.26 HLA-DRB1 HLA-C HLA-B HLA-A
6 cytokine activity GO:0005125 9.17 TNF IL6 IL4 IL2 IL1B IL10
Sources

Sources for Autoimmune Gastritis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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