MCID: ATM045
MIFTS: 36

Autoimmune Glomerulonephritis

Categories: Blood diseases, Immune diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Autoimmune Glomerulonephritis

MalaCards integrated aliases for Autoimmune Glomerulonephritis:

Name: Autoimmune Glomerulonephritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040094

Summaries for Autoimmune Glomerulonephritis

Disease Ontology : 12 An autoimmune disease of urogenital tract that is located in the renal glomerulus.

MalaCards based summary : Autoimmune Glomerulonephritis is related to glomerulonephritis and acute proliferative glomerulonephritis. An important gene associated with Autoimmune Glomerulonephritis is COL4A3 (Collagen Type IV Alpha 3 Chain), and among its related pathways/superpathways are Influenza A and Immune response Role of DAP12 receptors in NK cells. Affiliated tissues include t cells, kidney and lung, and related phenotypes are cellular and cardiovascular system

Related Diseases for Autoimmune Glomerulonephritis

Graphical network of the top 20 diseases related to Autoimmune Glomerulonephritis:



Diseases related to Autoimmune Glomerulonephritis

Symptoms & Phenotypes for Autoimmune Glomerulonephritis

MGI Mouse Phenotypes related to Autoimmune Glomerulonephritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 COL4A3 FCGR2B ICAM1 ITGB2 LRP2 SLK
2 cardiovascular system MP:0005385 9.98 COL4A3 FCGR2B ICAM1 ITGB2 LRP2 SLK
3 hematopoietic system MP:0005397 9.87 COL4A3 FCGR2B ICAM1 ITGB2 LRP2 TICAM1
4 homeostasis/metabolism MP:0005376 9.86 COL4A3 FCGR2B ICAM1 ITGB2 LRP2 SLK
5 digestive/alimentary MP:0005381 9.77 FCGR2B ICAM1 LRP2 TICAM1 TLR9
6 immune system MP:0005387 9.7 COL4A3 FCGR2B ICAM1 ITGB2 LRP2 TICAM1
7 mortality/aging MP:0010768 9.56 COL4A3 FCGR2B ICAM1 ITGB2 LRP2 SLK
8 vision/eye MP:0005391 9.1 COL4A3 ICAM1 ITGB2 LRP2 SLK TICAM1

Drugs & Therapeutics for Autoimmune Glomerulonephritis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Synergetic B-cell Immunomodulation in SLE - 2nd Study. Recruiting NCT03747159 Phase 2 Belimumab Injection
2 First in Human Study to Assess Safety of VIS649 in Healthy Subjects Recruiting NCT03719443 Phase 1

Search NIH Clinical Center for Autoimmune Glomerulonephritis

Genetic Tests for Autoimmune Glomerulonephritis

Anatomical Context for Autoimmune Glomerulonephritis

MalaCards organs/tissues related to Autoimmune Glomerulonephritis:

41
T Cells, Kidney, Lung, Neutrophil

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Glomerulonephritis:

19
The Renal Glomerulus

Publications for Autoimmune Glomerulonephritis

Articles related to Autoimmune Glomerulonephritis:

(show top 50) (show all 99)
# Title Authors Year
1
Inter-molecular epitope spreading does not lead to extension of autoimmunity beyond target tissue in autoimmune glomerulonephritis. ( 30153280 )
2018
2
Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice. ( 28637300 )
2017
3
The function of mast cells in autoimmune glomerulonephritis. ( 25388269 )
2015
4
TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis. ( 25965582 )
2015
5
BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa. ( 24477164 )
2014
6
Suppression of experimental autoimmune glomerulonephritis by tryptophan. ( 24519862 )
2014
7
A pilot study of leukocyte expression patterns for drug metabolizing enzyme and transporter transcripts in autoimmune glomerulonephritis. ( 24548980 )
2014
8
An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis. ( 24935958 )
2014
9
Decreased miR-26a expression correlates with the progression of podocyte injury in autoimmune glomerulonephritis. ( 25329154 )
2014
10
Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis. ( 25468389 )
2014
11
Peripheral blood CD8I+I+(+)CD11c(+)MHC-II(+)CD3(-) cells attenuate autoimmune glomerulonephritis in rats. ( 24257693 )
2013
12
The role of positive feedback loops involving anti-dsDNA and anti-anti-dsDNA antibodies in autoimmune glomerulonephritis. ( 23142592 )
2013
13
Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis. ( 22437418 )
2012
14
Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis. ( 21965585 )
2012
15
Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat. ( 22445570 )
2012
16
Role of PIR-B in autoimmune glomerulonephritis. ( 20976309 )
2011
17
Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1. ( 20167632 )
2010
18
Early relapse of autoimmune glomerulonephritis after kidney transplantation despite antibody induction and triple-drug-based immunosuppression. ( 20308867 )
2010
19
T cell vaccination therapy in an induced model of anti-RNP autoimmune glomerulonephritis. ( 20797908 )
2010
20
Editorial: Are men rats? Dendritic cells in autoimmune glomerulonephritis. ( 21041514 )
2010
21
Processes of homeostatic proliferation in the pathogenesis of autoimmune glomerulonephritis induced by chronic graft-versus-host reaction. ( 21113458 )
2010
22
Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. ( 18779924 )
2009
23
Identification of a nephritogenic immunodominant B and T cell epitope in experimental autoimmune glomerulonephritis. ( 19040602 )
2009
24
Overexpression of T-bet in T cells accelerates autoimmune glomerulonephritis in mice with a dominant Th1 background. ( 19229827 )
2009
25
Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice. ( 19395450 )
2009
26
Mucosal tolerance induced by an immunodominant peptide from rat alpha3(IV)NC1 in established experimental autoimmune glomerulonephritis. ( 19406992 )
2009
27
Kallikreins: unravelling the genetics of autoimmune glomerulonephritis. ( 19666659 )
2009
28
Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis. ( 18463609 )
2008
29
Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. ( 18097026 )
2008
30
Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ. ( 18228198 )
2008
31
A case of selective immunoglobulin M deficiency and autoimmune glomerulonephritis. ( 18365138 )
2008
32
Strain susceptibility to active induction and passive transfer of experimental autoimmune glomerulonephritis in the rat. ( 16998225 )
2006
33
A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis. ( 17005930 )
2006
34
A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis. ( 15680492 )
2005
35
Nasal administration of recombinant rat alpha3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis in the WKY rat. ( 15814836 )
2005
36
Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen. ( 16049074 )
2005
37
Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene. ( 14745006 )
2004
38
Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats. ( 15063164 )
2004
39
Blockade of the CD154-CD40 costimulatory pathway prevents the development of experimental autoimmune glomerulonephritis. ( 15458437 )
2004
40
Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vbeta T-cell receptor families in experimental autoimmune glomerulonephritis. ( 15528947 )
2004
41
Immunodominant epitopes of alpha3(IV)NC1 induce autoimmune glomerulonephritis in rats. ( 14633133 )
2003
42
Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background. ( 14514727 )
2003
43
Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. ( 12571859 )
2003
44
Point mutations of single amino acids abolish ability of alpha3 NC1 domain to elicit experimental autoimmune glomerulonephritis in rats. ( 12970356 )
2003
45
A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia. ( 12370404 )
2002
46
Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis. ( 11805163 )
2002
47
Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene. ( 12381925 )
2002
48
Oral administration of glomerular basement membrane prevents the development of experimental autoimmune glomerulonephritis in the WKY rat. ( 11134251 )
2001
49
Expression and characterization of recombinant rat alpha 3(IV)NC1 and its use in induction of experimental autoimmune glomerulonephritis. ( 11158397 )
2001
50
T-cell-specific therapy in autoimmune glomerulonephritis. ( 11728969 )
2001

Variations for Autoimmune Glomerulonephritis

Expression for Autoimmune Glomerulonephritis

Search GEO for disease gene expression data for Autoimmune Glomerulonephritis.

Pathways for Autoimmune Glomerulonephritis

GO Terms for Autoimmune Glomerulonephritis

Cellular components related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immunological synapse GO:0001772 8.96 GZMB ICAM1
2 external side of plasma membrane GO:0009897 8.92 FCGR2B ICAM1 ITGB2 LRP2

Biological processes related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.78 GZMB ITGB2 SLK TICAM1
2 regulation of immune response GO:0050776 9.63 FCGR2B ICAM1 ITGB2
3 extracellular matrix organization GO:0030198 9.61 COL4A3 ICAM1 ITGB2
4 inflammatory response GO:0006954 9.56 FCGR2B ITGB2 TICAM1 TLR9
5 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.55 TICAM1 TLR9
6 positive regulation of interleukin-6 production GO:0032755 9.54 TICAM1 TLR9
7 positive regulation of tumor necrosis factor production GO:0032760 9.52 TICAM1 TLR9
8 positive regulation of B cell proliferation GO:0030890 9.51 TICAM1 TLR9
9 sensory perception of sound GO:0007605 9.5 COL4A3 ICAM1 LRP2
10 positive regulation of neuron death GO:1901216 9.49 FCGR2B ITGB2
11 leukocyte cell-cell adhesion GO:0007159 9.4 ICAM1 ITGB2
12 cell adhesion mediated by integrin GO:0033627 9.37 ICAM1 ITGB2
13 positive regulation of interferon-beta biosynthetic process GO:0045359 9.16 TICAM1 TLR9
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.13 ICAM1 ITGB2 TICAM1
15 positive regulation of NF-kappaB transcription factor activity GO:0051092 8.92 ICAM1 ITGB2 TICAM1 TLR9

Molecular functions related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.16 FCGR2B ITGB2
2 protein-containing complex binding GO:0044877 9.13 FCGR2B ICAM1 ITGB2
3 integrin binding GO:0005178 8.8 COL4A3 ICAM1 ITGB2

Sources for Autoimmune Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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