MCID: ATM045
MIFTS: 38

Autoimmune Glomerulonephritis

Categories: Blood diseases, Immune diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Autoimmune Glomerulonephritis

MalaCards integrated aliases for Autoimmune Glomerulonephritis:

Name: Autoimmune Glomerulonephritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040094

Summaries for Autoimmune Glomerulonephritis

Disease Ontology : 12 An autoimmune disease of urogenital tract that is located in the renal glomerulus.

MalaCards based summary : Autoimmune Glomerulonephritis is related to glomerulonephritis and acute proliferative glomerulonephritis. An important gene associated with Autoimmune Glomerulonephritis is COL4A3 (Collagen Type IV Alpha 3 Chain), and among its related pathways/superpathways are NF-kappaB Signaling and Immune response Role of DAP12 receptors in NK cells. The drugs Mycophenolic acid and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and kidney, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Autoimmune Glomerulonephritis

Diseases in the Glomerulonephritis family:

Autoimmune Glomerulonephritis Subacute Glomerulonephritis

Diseases related to Autoimmune Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 10.8
2 acute proliferative glomerulonephritis 10.2 COL4A3 ICAM1
3 annular erythema 10.2 ICAM1 ITGB2
4 mooren's ulcer 10.2 ICAM1 ITGB2
5 leukocyte adhesion deficiency, type i 10.2 ICAM1 ITGB2
6 erythema multiforme 10.1 GZMB ICAM1
7 cutaneous lupus erythematosus 10.0 GZMB ICAM1
8 neutrophil migration 10.0 ICAM1 ITGB2
9 goodpasture syndrome 10.0 COL4A3 FCGR2B
10 pustulosis palmaris et plantaris 10.0 CCR6 ITGB2
11 alopecia areata 9.9 GZMB ICAM1
12 hemolytic anemia 9.8
13 selective igm deficiency disease 9.8
14 sialadenitis 9.8
15 cryoglobulinemia 9.8

Graphical network of the top 20 diseases related to Autoimmune Glomerulonephritis:



Diseases related to Autoimmune Glomerulonephritis

Symptoms & Phenotypes for Autoimmune Glomerulonephritis

MGI Mouse Phenotypes related to Autoimmune Glomerulonephritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 COL4A3 EBI3 FCGR2B ICAM1 ITGB2 SLK
2 homeostasis/metabolism MP:0005376 9.76 CCR6 COL4A3 EBI3 FCGR2B ICAM1 ITGB2
3 hematopoietic system MP:0005397 9.73 CCR6 EBI3 FCGR2B ICAM1 ITGB2 TICAM1
4 immune system MP:0005387 9.5 CCR6 COL4A3 EBI3 FCGR2B ICAM1 ITGB2
5 vision/eye MP:0005391 9.02 COL4A3 ICAM1 ITGB2 SLK TICAM1

Drugs & Therapeutics for Autoimmune Glomerulonephritis

Drugs for Autoimmune Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 2 24280-93-1 446541
2
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
3
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
5
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
6
belimumab Approved Phase 2 356547-88-1 5957 10451420
7
rituximab Approved Phase 2 174722-31-7 10201696
8
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
9 Prednisolone acetate Phase 2
10 Peripheral Nervous System Agents Phase 2
11 Anti-Bacterial Agents Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Antineoplastic Agents, Immunological Phase 2
14 Hormones Phase 2
15 Anti-Infective Agents Phase 2
16 Autonomic Agents Phase 2
17 Immunosuppressive Agents Phase 2
18 Hormone Antagonists Phase 2
19 Immunologic Factors Phase 2
20 Antibiotics, Antitubercular Phase 2
21 Antiemetics Phase 2
22 Antitubercular Agents Phase 2
23 Methylprednisolone Acetate Phase 2
24 Neuroprotective Agents Phase 2
25 Antirheumatic Agents Phase 2
26 Gastrointestinal Agents Phase 2
27 glucocorticoids Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
29 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Synergetic B-cell Immunomodulation in SLE - 2nd Study. Recruiting NCT03747159 Phase 2 Belimumab Injection
2 First in Human Study to Assess Safety of VIS649 in Healthy Subjects Recruiting NCT03719443 Phase 1

Search NIH Clinical Center for Autoimmune Glomerulonephritis

Genetic Tests for Autoimmune Glomerulonephritis

Anatomical Context for Autoimmune Glomerulonephritis

MalaCards organs/tissues related to Autoimmune Glomerulonephritis:

42
T Cells, B Cells, Kidney, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Glomerulonephritis:

20
The Renal Glomerulus

Publications for Autoimmune Glomerulonephritis

Articles related to Autoimmune Glomerulonephritis:

(show top 50) (show all 101)
# Title Authors Year
1
Role of regulatory T cells in experimental autoimmune glomerulonephritis. ( 30648909 )
2019
2
Dendritic cell-targeted CD40 DNA vaccine suppresses Th17 and ameliorates progression of experimental autoimmune glomerulonephritis. ( 30811635 )
2019
3
Inter-molecular epitope spreading does not lead to extension of autoimmunity beyond target tissue in autoimmune glomerulonephritis. ( 30153280 )
2018
4
Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice. ( 28637300 )
2017
5
The function of mast cells in autoimmune glomerulonephritis. ( 25388269 )
2015
6
TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis. ( 25965582 )
2015
7
BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa. ( 24477164 )
2014
8
Suppression of experimental autoimmune glomerulonephritis by tryptophan. ( 24519862 )
2014
9
A pilot study of leukocyte expression patterns for drug metabolizing enzyme and transporter transcripts in autoimmune glomerulonephritis. ( 24548980 )
2014
10
An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis. ( 24935958 )
2014
11
Decreased miR-26a expression correlates with the progression of podocyte injury in autoimmune glomerulonephritis. ( 25329154 )
2014
12
Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis. ( 25468389 )
2014
13
Peripheral blood CD8I+I+(+)CD11c(+)MHC-II(+)CD3(-) cells attenuate autoimmune glomerulonephritis in rats. ( 24257693 )
2013
14
The role of positive feedback loops involving anti-dsDNA and anti-anti-dsDNA antibodies in autoimmune glomerulonephritis. ( 23142592 )
2013
15
Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis. ( 22437418 )
2012
16
Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis. ( 21965585 )
2012
17
Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat. ( 22445570 )
2012
18
Role of PIR-B in autoimmune glomerulonephritis. ( 20976309 )
2011
19
Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1. ( 20167632 )
2010
20
Early relapse of autoimmune glomerulonephritis after kidney transplantation despite antibody induction and triple-drug-based immunosuppression. ( 20308867 )
2010
21
T cell vaccination therapy in an induced model of anti-RNP autoimmune glomerulonephritis. ( 20797908 )
2010
22
Editorial: Are men rats? Dendritic cells in autoimmune glomerulonephritis. ( 21041514 )
2010
23
Processes of homeostatic proliferation in the pathogenesis of autoimmune glomerulonephritis induced by chronic graft-versus-host reaction. ( 21113458 )
2010
24
Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. ( 18779924 )
2009
25
Identification of a nephritogenic immunodominant B and T cell epitope in experimental autoimmune glomerulonephritis. ( 19040602 )
2009
26
Overexpression of T-bet in T cells accelerates autoimmune glomerulonephritis in mice with a dominant Th1 background. ( 19229827 )
2009
27
Onset of autoimmune glomerulonephritis derived from the telomeric region of MRL-chromosome 1 is associated with the male sex hormone in mice. ( 19395450 )
2009
28
Mucosal tolerance induced by an immunodominant peptide from rat alpha3(IV)NC1 in established experimental autoimmune glomerulonephritis. ( 19406992 )
2009
29
Kallikreins: unravelling the genetics of autoimmune glomerulonephritis. ( 19666659 )
2009
30
Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis. ( 18463609 )
2008
31
Targeted deletion of fgl2 leads to impaired regulatory T cell activity and development of autoimmune glomerulonephritis. ( 18097026 )
2008
32
Autoimmune glomerulonephritis induced in congenic mouse strain carrying telomeric region of chromosome 1 derived from MRL/MpJ. ( 18228198 )
2008
33
A case of selective immunoglobulin M deficiency and autoimmune glomerulonephritis. ( 18365138 )
2008
34
Strain susceptibility to active induction and passive transfer of experimental autoimmune glomerulonephritis in the rat. ( 16998225 )
2006
35
A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis. ( 17005930 )
2006
36
A novel immunosuppressant FTY720 ameliorates proteinuria and alterations of intrarenal adrenomedullin in rats with autoimmune glomerulonephritis. ( 15680492 )
2005
37
Nasal administration of recombinant rat alpha3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis in the WKY rat. ( 15814836 )
2005
38
Epitope spreading and autoimmune glomerulonephritis in rats induced by a T cell epitope of Goodpasture's antigen. ( 16049074 )
2005
39
Autoimmune glomerulonephritis with spontaneous formation of splenic germinal centers in mice lacking the estrogen receptor alpha gene. ( 14745006 )
2004
40
Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats. ( 15063164 )
2004
41
Blockade of the CD154-CD40 costimulatory pathway prevents the development of experimental autoimmune glomerulonephritis. ( 15458437 )
2004
42
Glomerular T cells are of restricted clonality and express multiple CDR3 motifs across different Vbeta T-cell receptor families in experimental autoimmune glomerulonephritis. ( 15528947 )
2004
43
Immunodominant epitopes of alpha3(IV)NC1 induce autoimmune glomerulonephritis in rats. ( 14633133 )
2003
44
Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background. ( 14514727 )
2003
45
Fc receptor-independent development of autoimmune glomerulonephritis in lupus-prone MRL/lpr mice. ( 12571859 )
2003
46
Point mutations of single amino acids abolish ability of alpha3 NC1 domain to elicit experimental autoimmune glomerulonephritis in rats. ( 12970356 )
2003
47
A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia. ( 12370404 )
2002
48
Anti-CD8 monoclonal antibody therapy is effective in the prevention and treatment of experimental autoimmune glomerulonephritis. ( 11805163 )
2002
49
Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene. ( 12381925 )
2002
50
Oral administration of glomerular basement membrane prevents the development of experimental autoimmune glomerulonephritis in the WKY rat. ( 11134251 )
2001

Variations for Autoimmune Glomerulonephritis

Expression for Autoimmune Glomerulonephritis

Search GEO for disease gene expression data for Autoimmune Glomerulonephritis.

Pathways for Autoimmune Glomerulonephritis

GO Terms for Autoimmune Glomerulonephritis

Cellular components related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.02 CCR6 EBI3 FCGR2B ICAM1 ITGB2
2 immunological synapse GO:0001772 8.96 GZMB ICAM1

Biological processes related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.76 GZMB ITGB2 SLK TICAM1
2 regulation of immune response GO:0050776 9.58 FCGR2B ICAM1 ITGB2
3 extracellular matrix organization GO:0030198 9.54 COL4A3 ICAM1 ITGB2
4 humoral immune response GO:0006959 9.48 CCR6 EBI3
5 positive regulation of neuron death GO:1901216 9.43 FCGR2B ITGB2
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.33 ICAM1 ITGB2 TICAM1
7 leukocyte cell-cell adhesion GO:0007159 9.32 ICAM1 ITGB2
8 cell adhesion mediated by integrin GO:0033627 9.26 ICAM1 ITGB2
9 leukocyte migration involved in inflammatory response GO:0002523 8.96 CCR6 ITGB2
10 positive regulation of nitric oxide biosynthetic process GO:0045429 8.8 ICAM1 ITGB2 TICAM1

Molecular functions related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.33 FCGR2B ICAM1 ITGB2
2 amyloid-beta binding GO:0001540 9.26 FCGR2B ITGB2
3 signaling receptor activity GO:0038023 9.13 CCR6 ICAM1 ITGB2
4 integrin binding GO:0005178 8.8 COL4A3 ICAM1 ITGB2

Sources for Autoimmune Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....