MCID: ATM045
MIFTS: 33

Autoimmune Glomerulonephritis

Categories: Blood diseases, Immune diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Autoimmune Glomerulonephritis

MalaCards integrated aliases for Autoimmune Glomerulonephritis:

Name: Autoimmune Glomerulonephritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040094

Summaries for Autoimmune Glomerulonephritis

Disease Ontology : 12 An autoimmune disease of urogenital tract that is located in the renal glomerulus.

MalaCards based summary : Autoimmune Glomerulonephritis is related to anti-basement membrane glomerulonephritis and goodpasture syndrome. An important gene associated with Autoimmune Glomerulonephritis is COL4A3 (Collagen Type IV Alpha 3 Chain), and among its related pathways/superpathways are Allograft rejection and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs Methylprednisolone hemisuccinate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include renal glomerulus, t cells and kidney.

Related Diseases for Autoimmune Glomerulonephritis

Diseases in the Glomerulonephritis family:

Autoimmune Glomerulonephritis Subacute Glomerulonephritis

Diseases related to Autoimmune Glomerulonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 anti-basement membrane glomerulonephritis 30.2 COL4A3 CD4 CCR6
2 goodpasture syndrome 30.0 FCGR2B COL4A3 CD4
3 sialadenitis 29.4 ICOSLG EBI3 CD8A CD4 CCR6
4 systemic lupus erythematosus 28.8 ITGB2 ICOSLG ICAM1 FCGR2B CD8A CD4
5 glomerulonephritis 10.8
6 annular erythema 10.6 ITGB2 ICAM1
7 herpes simplex virus keratitis 10.4 ICAM1 CD4
8 mooren's ulcer 10.4 ITGB2 ICAM1
9 suppurative lymphadenitis 10.4 CD4 CCR6
10 autoimmune disease 10.4
11 abacavir allergy 10.4 GZMB CD4
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
13 autoimmune peripheral neuropathy 10.4 ICOSLG CD4
14 chancroid 10.3 CD4 CCR6
15 toxicodendron dermatitis 10.3 ICAM1 CD8A
16 leukocyte adhesion deficiency, type i 10.3 ITGB2 ICAM1 CCR6
17 lichen sclerosus et atrophicus 10.3 GZMB CD8A
18 cork-handlers' disease 10.3 CD8A CD4
19 lymphocytic gastritis 10.3 GZMB CD8A
20 syphilitic meningitis 10.3 CD8A CD4
21 crescentic glomerulonephritis 10.3
22 ventilation pneumonitis 10.3 CD8A CD4
23 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
24 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
25 mikulicz disease 10.3 ICOSLG CD4 CCR6
26 chromosome 14q11-q22 deletion syndrome 10.3 CD8A CD4
27 chronic conjunctivitis 10.3 ICOSLG CD4 CCR6
28 diabetes mellitus, insulin-dependent, 23 10.3 CD8A CD4
29 nut allergy 10.3 ICOSLG CD4 CCR6
30 bird fancier's lung 10.3 CD8A CD4
31 igg4-related disease 10.3 ICOSLG CD4 CCR6
32 autoimmune disease of skin and connective tissue 10.3 ICOSLG CD4 CCR6
33 early yaws 10.3 CD8A CD4
34 parapsoriasis 10.3 CD8A CD4
35 norwegian scabies 10.3 CD8A CD4
36 adult t-cell leukemia 10.3 ICAM1 CD4 CCR6
37 bullous skin disease 10.3 ICOSLG CD4 CCR6
38 metal allergy 10.3 CD8A CD4
39 variola major 10.3 CD8A CD4
40 follicular mucinosis 10.3 CD8A CD4
41 tertiary syphilis 10.2 CD8A CD4
42 thrombocytopenic purpura, autoimmune 10.2 ICOSLG CD4 CCR6
43 acute retinal necrosis syndrome 10.2 CD8A CD4
44 granulomatous hepatitis 10.2 CD8A CD4
45 nickel allergic contact dermatitis 10.2 CD8A CD4
46 cranial nerve disease 10.2 ICOSLG CD4 CCR6
47 combined thymoma 10.2 CD8A CD4
48 west nile encephalitis 10.2 CD8A CD4
49 neurosarcoidosis 10.2 CD8A CD4
50 cd3zeta deficiency 10.2 CD8A CD4

Graphical network of the top 20 diseases related to Autoimmune Glomerulonephritis:



Diseases related to Autoimmune Glomerulonephritis

Symptoms & Phenotypes for Autoimmune Glomerulonephritis

Drugs & Therapeutics for Autoimmune Glomerulonephritis

Drugs for Autoimmune Glomerulonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
2
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
5
belimumab Approved Phase 2 356547-88-1 5957 10451420
6
rituximab Approved Phase 2 174722-31-7 10201696
7
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
8
Mycophenolic acid Approved Phase 2 24280-93-1 446541
9
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
10 Methylprednisolone Acetate Phase 2
11 Antineoplastic Agents, Immunological Phase 2
12 Antirheumatic Agents Phase 2
13 Immunosuppressive Agents Phase 2
14 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial to Investigate the Reset of Humoral Autoimmunity by Combining Belimumab With Rituximab in Severe Systemic Lupus Erythematosus Recruiting NCT03747159 Phase 2 Belimumab Injection
2 A Phase 1, Randomized, Placebo-Controlled, Single Ascending Dose First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of VIS649 Administered Intravenously in Healthy Subjects Completed NCT03719443 Phase 1

Search NIH Clinical Center for Autoimmune Glomerulonephritis

Genetic Tests for Autoimmune Glomerulonephritis

Anatomical Context for Autoimmune Glomerulonephritis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Glomerulonephritis:

19
Renal Glomerulus

MalaCards organs/tissues related to Autoimmune Glomerulonephritis:

40
T Cells, Kidney, Lung, B Cells, Skin, Myeloid, Eye

Publications for Autoimmune Glomerulonephritis

Articles related to Autoimmune Glomerulonephritis:

(show top 50) (show all 214)
# Title Authors PMID Year
1
Clinical Value of Complement Activation Biomarkers in Overt Diabetic Nephropathy. 61
31194090 2019
2
TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease. 61
30953689 2019
3
Neutrophil Extracellular Traps protein composition is specific for patients with Lupus nephritis and includes methyl-oxidized αenolase (methionine sulfoxide 93). 61
31138830 2019
4
Dendritic cell-targeted CD40 DNA vaccine suppresses Th17 and ameliorates progression of experimental autoimmune glomerulonephritis. 61
30811635 2019
5
Induced expression of Toll-like receptor 9 in peritubular capillary endothelium correlates with the progression of tubulointerstitial lesions in autoimmune disease-prone mice. 61
30813872 2019
6
Role of regulatory T cells in experimental autoimmune glomerulonephritis. 61
30648909 2019
7
Primary membranous nephropathy with concomitant IgA nephropathy. 61
31031392 2019
8
Mangiferin Attenuates Murine Lupus Nephritis by Inducing CD4+Foxp3+ Regulatory T Cells via Suppression of mTOR Signaling. 61
30359968 2018
9
Inter-molecular epitope spreading does not lead to extension of autoimmunity beyond target tissue in autoimmune glomerulonephritis. 61
30153280 2018
10
Regulatory T cells in renal disease. 61
29484182 2018
11
The pathogenicity of T cell epitopes on human Goodpasture antigen and its critical amino acid motif. 61
28296059 2017
12
Local CD34-positive capillaries decrease in mouse models of kidney disease associating with the severity of glomerular and tubulointerstitial lesions. 61
28870174 2017
13
Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice. 61
28637300 2017
14
Effects of a spleen tyrosine kinase inhibitor on progression of the lupus nephritis in mice. 61
28479222 2017
15
CD8αα+MHC Class II+ Cell with the Capacity To Terminate Autoimmune Inflammation Is a Novel Antigen-Presenting NK-like Cell in Rats. 61
27799310 2016
16
Nivolumab-associated acute glomerulonephritis: a case report and literature review. 61
27876011 2016
17
Overexpression of Fibrinogen-Like Protein 2 Promotes Tolerance in a Fully Mismatched Murine Model of Heart Transplantation. 61
26718313 2016
18
Anti-Glomerular Basement Membrane Disease Combined with IgA Nephropathy Complicated with Reversible Posterior Leukoencephalopathy Syndrome: An Unusual Case. 61
26621456 2015
19
TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis. 61
25965582 2015
20
Autoimmunity to the alpha 3 chain of type IV collagen in glomerulonephritis is triggered by 'autoantigen complementarity'. 61
25841937 2015
21
Glomerulopathy induced by immunization with a peptide derived from the goodpasture antigen α3IV-NC1. 61
25769923 2015
22
The function of mast cells in autoimmune glomerulonephritis. 61
25388269 2015
23
Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis. 61
25468389 2014
24
An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis. 61
24935958 2014
25
Peripheral blood CD8αα+CD11c+MHC-II+CD3- cells attenuate autoimmune glomerulonephritis in rats. 61
24257693 2014
26
Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf. 61
24632712 2014
27
A pilot study of leukocyte expression patterns for drug metabolizing enzyme and transporter transcripts in autoimmune glomerulonephritis. 61
24548980 2014
28
BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa. 61
24477164 2014
29
Suppression of experimental autoimmune glomerulonephritis by tryptophan. 61
24519862 2014
30
Comparative effects of n-3, n-6 and n-9 unsaturated fatty acid-rich diet consumption on lupus nephritis, autoantibody production and CD4+ T cell-related gene responses in the autoimmune NZBWF1 mouse. 61
24945254 2014
31
Decreased miR-26a expression correlates with the progression of podocyte injury in autoimmune glomerulonephritis. 61
25329154 2014
32
Overexpression of Epstein-Barr virus-induced gene 3 protein (EBI3) in MRL/lpr mice suppresses their lupus nephritis by activating regulatory T cells. 61
23845089 2013
33
Experimental crescentic glomerulonephritis: a new bicongenic rat model. 61
24046355 2013
34
Physiological functions and clinical implications of fibrinogen-like 2: A review. 61
26161303 2013
35
The role of positive feedback loops involving anti-dsDNA and anti-anti-dsDNA antibodies in autoimmune glomerulonephritis. 61
23142592 2013
36
Epistasis and immunity: the role of genetic interactions in autoimmune diseases. 61
22804709 2012
37
Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis. 61
22437418 2012
38
Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat. 61
22445570 2012
39
Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis. 61
21965585 2012
40
Decoy receptor 3 inhibits renal mononuclear leukocyte infiltration and apoptosis and prevents progression of IgA nephropathy in mice. 61
21900455 2011
41
Suppressive effects of imidapril on Th1- and Th2-related chemokines in monocytes. 61
21849907 2011
42
Strain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis. 61
21342299 2011
43
Autoimmune kidney disease and impaired engulfment of apoptotic cells in mice with macrophage peroxisome proliferator-activated receptor gamma or retinoid X receptor alpha deficiency. 61
21135166 2011
44
Role of PIR-B in autoimmune glomerulonephritis. 61
20976309 2011
45
Update on antiglomerular basement membrane disease. 61
21124085 2011
46
Editorial: Are men rats? Dendritic cells in autoimmune glomerulonephritis. 61
21041514 2010
47
T cell vaccination therapy in an induced model of anti-RNP autoimmune glomerulonephritis. 61
20797908 2010
48
Processes of homeostatic proliferation in the pathogenesis of autoimmune glomerulonephritis induced by chronic graft-versus-host reaction. 61
21113458 2010
49
Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1. 61
20167632 2010
50
Early relapse of autoimmune glomerulonephritis after kidney transplantation despite antibody induction and triple-drug-based immunosuppression. 61
20308867 2010

Variations for Autoimmune Glomerulonephritis

Expression for Autoimmune Glomerulonephritis

Search GEO for disease gene expression data for Autoimmune Glomerulonephritis.

Pathways for Autoimmune Glomerulonephritis

Pathways related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.37 ITGB2 ICOSLG ICAM1 GZMB CD8A CD4
2 11.69 ITGB2 ICAM1 FCGR2B CD8A
3
Show member pathways
11.6 GZMB CD8A CD4
4 11.48 ITGB2 ICAM1 FCGR2B
5 11.19 ITGB2 ICOSLG ICAM1 CD8A CD4
6 11.16 GZMB CD8A CD4 CCR6

GO Terms for Autoimmune Glomerulonephritis

Cellular components related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.23 ITGB2 ICOSLG ICAM1 FCGR2B EBI3 CD8A

Biological processes related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 9.43 ICOSLG CD8A CD4
2 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.37 ITGB2 ICAM1
3 leukocyte migration involved in inflammatory response GO:0002523 9.32 ITGB2 CCR6
4 negative regulation of dendritic cell antigen processing and presentation GO:0002605 9.16 FGL2 FCGR2B
5 regulation of immune response GO:0050776 9.02 ITGB2 ICOSLG ICAM1 FCGR2B CD8A
6 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 8.96 ICAM1 FGL2

Molecular functions related to Autoimmune Glomerulonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 8.92 ITGB2 ICAM1 CD4 CCR6

Sources for Autoimmune Glomerulonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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