AIH
MCID: ATM011
MIFTS: 61

Autoimmune Hepatitis (AIH)

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Liver diseases, Rare diseases, Skin diseases

Aliases & Classifications for Autoimmune Hepatitis

MalaCards integrated aliases for Autoimmune Hepatitis:

Name: Autoimmune Hepatitis 38 12 76 53 59 37 15
Hepatitis, Autoimmune 44 73
Autoimmune Hepatitis with Centrilobular Necrosis 12
Autoimmune Chronic Active Hepatitis 12
Autoimmune Chronic Hepatitis 53
Chronic Autoimmune Hepatitis 59
Hepatitis Autoimmune 55
Aih 53

Characteristics:

Orphanet epidemiological data:

59
autoimmune hepatitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Norway),1-5/10000 (Norway),1-9/1000000 (Sweden),1-5/10000 (New Zealand),1-9/1000000 (Spain),1-5/10000 (Spain),1-5/10000 (Sweden),1-9/1000000 (Israel),1-5/10000 (Israel),1-9/100000 (Denmark),1-5/10000 (Denmark),1-9/100000 (Singapore),1-9/100000; Age of onset: Adult;

Classifications:

Orphanet: 59  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:2048
ICD10 33 K75.4
ICD9CM 35 571.42
MeSH 44 D019693
SNOMED-CT 68 68784009
Orphanet 59 ORPHA2137
UMLS via Orphanet 74 C0241910
ICD10 via Orphanet 34 K75.4
KEGG 37 H01685

Summaries for Autoimmune Hepatitis

NIH Rare Diseases : 53 Autoimmune hepatitis is a disease in which the body�??s immune system attacks liver cells. This immune response causes inflammation of the liver, also called hepatitis. The disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. Autoimmune hepatitis likely results from a combination of autoimmunity, environmental triggers, and a genetic predisposition. It occurs more frequently in females. Treatment typically includes corticosteroids and medications that suppress the immune system. In severe cases, a liver transplant may be needed.

MalaCards based summary : Autoimmune Hepatitis, also known as hepatitis, autoimmune, is related to hepatitis and hepatitis a. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase), and among its related pathways/superpathways are Allograft rejection and Epstein-Barr virus infection. The drugs Intron A and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include Blood and Umbilical Cord, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that results in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia : 76 Autoimmune hepatitis, formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver... more...

Related Diseases for Autoimmune Hepatitis

Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis a
Hepatitis C Viral Hepatitis
Hepatitis D Hepatitis E

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 294)
# Related Disease Score Top Affiliating Genes
1 hepatitis 31.7 F2 GGT1 GPT KRT8 SEPSECS
2 hepatitis a 31.1 F2 GPT SEPSECS
3 primary biliary cirrhosis 30.7 CTLA4 DLAT F2 GGT1 SEPSECS
4 cholangitis 30.5 DLAT F2 GGT1 GPT HLA-DRB1
5 infantile liver failure syndrome 1 30.4 F2 GPT
6 celiac disease 1 30.4 CTLA4 HLA-A HLA-DQB1
7 hepatitis b 30.2 CTLA4 F2 GGT1 GPT
8 cryptogenic cirrhosis 30.1 F2 KRT8
9 cholangitis, primary sclerosing 30.0 AIRE DLAT GGT1 GPT HLA-A SEPSECS
10 liver cirrhosis 30.0 F2 GGT1 GPT KRT8
11 systemic lupus erythematosus 29.9 CTLA4 F2 FAS HLA-DQB1 HLA-DRB1 PDCD1
12 viral hepatitis 29.9 F2 FAS GGT1 GPT SEPSECS
13 multiple sclerosis 29.8 CTLA4 HLA-DQB1 HLA-DRB1 PDCD1
14 hashimoto thyroiditis 29.8 AIRE CTLA4 FAS
15 liver disease 29.6 DLAT F2 FAS GGT1 GOLM1 GPT
16 hepatic coma 29.6 F2 GPT
17 diabetes mellitus 29.6 AIRE CTLA4 FAS HLA-A HLA-DQB1 HLA-DRB1
18 autoimmune disease 29.5 AIRE CTLA4 FAS HLA-DQB1 HLA-DRB1 PDCD1
19 cholestasis 29.5 F2 GGT1 GPT
20 vitiligo-associated multiple autoimmune disease susceptibility 1 29.4 AIRE CTLA4 PDCD1
21 diabetes mellitus, insulin-dependent 29.3 AIRE CTLA4 HLA-A HLA-DQB1 HLA-DRB1
22 amelogenesis imperfecta hypomaturation type 11.1
23 primary biliary cholangitis 10.6
24 biliary cirrhosis, primary, 1 10.6
25 sclerosing cholangitis 10.4
26 hepatitis c 10.4
27 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
28 type 1 diabetes mellitus 12 10.3 CTLA4 HLA-DRB1
29 narcolepsy 2 10.3 HLA-DQB1 HLA-DRB1
30 hepatocellular carcinoma 10.3
31 postherpetic neuralgia 10.3 HLA-A HLA-DRB1
32 autoimmune polyglandular syndrome type 3 10.3 HLA-DQB1 HLA-DRB1
33 hypersomnia 10.3 HLA-DQB1 HLA-DRB1
34 metal allergy 10.3 HLA-DQB1 HLA-DRB1
35 lichen planopilaris 10.3 HLA-DQB1 HLA-DRB1
36 anca-associated vasculitis 10.2 CTLA4 HLA-DRB1
37 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
38 recurrent respiratory papillomatosis 10.2 HLA-DQB1 HLA-DRB1
39 narcolepsy 1 10.2 HLA-DQB1 HLA-DRB1
40 lupus erythematosus 10.2
41 hepatoportal sclerosis 10.2 F2 GPT
42 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
43 pars planitis 10.2 HLA-A HLA-DRB1
44 acute liver failure 10.2
45 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
46 caplan's syndrome 10.2 FAS HLA-A
47 qualitative platelet defect 10.2 F2 HLA-A
48 delusional disorder 10.2 CYP2D6 HLA-A
49 amelogenesis imperfecta, type ie 10.2 CYP2D6 FTCD SEPSECS
50 pityriasis rosea 10.2 HLA-A HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to Autoimmune Hepatitis

Symptoms & Phenotypes for Autoimmune Hepatitis

MGI Mouse Phenotypes related to Autoimmune Hepatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.15 AIRE CTLA4 CYP1A2 DDC F2 FAS
2 cardiovascular system MP:0005385 10.06 CTLA4 CYP1A2 DDC F2 FAS GOLM1
3 immune system MP:0005387 10.02 AIRE CTLA4 DDC F2 FAS GGT1
4 mortality/aging MP:0010768 9.93 AIRE CTLA4 CYP1A2 DDC F2 FAS
5 liver/biliary system MP:0005370 9.86 AIRE CTLA4 CYP1A2 FAS GOLM1 HLA-DQB1
6 reproductive system MP:0005389 9.56 AIRE DDC F2 FAS GGT1 HLA-DQB1
7 respiratory system MP:0005388 9.17 AIRE CTLA4 CYP1A2 F2 FAS HLA-DQB1

Drugs & Therapeutics for Autoimmune Hepatitis

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Intron A 18 49 INTERFERON ALFA-2B Schering-Plough December 1997/ December 1995/ March 1997

Drugs for Autoimmune Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Not Applicable 2921-57-5
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Not Applicable 302-25-0
5
Azathioprine Approved Phase 4,Phase 2,Not Applicable 446-86-6 2265
6
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
7
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
8
Mycophenolic acid Approved Phase 4 24280-93-1 446541
9
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Not Applicable 2920-86-7
10 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
13 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
16 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
17 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
18 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
19 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
20 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
21 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
23 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
24 Prednisolone acetate Phase 4,Phase 3,Not Applicable
25 Methylprednisolone acetate Phase 4,Phase 3,Not Applicable
26 Protective Agents Phase 4,Phase 3
27 Neuroprotective Agents Phase 4,Phase 3
28 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
29 Liver Extracts Phase 4,Phase 1,Phase 2,Not Applicable
30 Antiemetics Phase 4,Phase 3
31 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Anti-Bacterial Agents Phase 4,Not Applicable
33 Antibiotics, Antitubercular Phase 4,Not Applicable
34 Anthelmintics Phase 4
35 Chloroquine diphosphate Phase 4 50-63-5
36 Antiparasitic Agents Phase 4,Not Applicable
37 Antimetabolites, Antineoplastic Phase 4,Phase 2
38 Antiprotozoal Agents Phase 4,Not Applicable
39 Antimalarials Phase 4
40 Antimetabolites Phase 4,Phase 2
41 Antitubercular Agents Phase 4
42
Miconazole Approved, Investigational, Vet_approved Phase 3,Not Applicable 22916-47-8 4189
43
Budesonide Approved Phase 2, Phase 3,Not Applicable 51333-22-3 63006 5281004
44 Cyclosporins Phase 3
45 Calcineurin Inhibitors Phase 3,Phase 2
46 Dermatologic Agents Phase 3
47 Antifungal Agents Phase 3,Not Applicable
48 Respiratory System Agents Phase 2, Phase 3,Not Applicable
49 Anti-Asthmatic Agents Phase 2, Phase 3,Not Applicable
50 Bronchodilator Agents Phase 2, Phase 3,Not Applicable

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Possible Role of Chloroquine to Induce a Complete Remission in the Treatment of Autoimmune Hepatitis: a Randomized Trial Completed NCT02463331 Phase 4 Chloroquine diphosphate;prednisone;azathioprine
2 CHLOROQUINE FOR MAINTENANCE REMISSION OF AUTOIMMUNE HEPATITIS Completed NCT01980745 Phase 4 Chloroquine diphosphate 250mg;Placebo
3 Mycophenolate vs Azathioprin in Autoimmune Hepatitis Completed NCT00687180 Phase 4 Treatment with mycophenolat mofetil;Treatment with azathioprin
4 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
5 Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis Recruiting NCT02900443 Phase 4 Mycophenolate mofetil;Azathioprine
6 Cyclosporine-A Versus Prednisolone for Induction of Remission in Auto-immune Hepatitis Unknown status NCT01170351 Phase 3 Cyclosporine-A
7 Budesonide 3x3mg/d Versus Prednisone in Active Autoimmune Hepatitis Completed NCT00838214 Phase 2, Phase 3 budesonide;prednisone
8 ADCC Mediated B-Cell dEpletion and BAFF-R Blockade Recruiting NCT03217422 Phase 2, Phase 3
9 Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis Withdrawn NCT02878863 Phase 3 Paeoniflorin + phosphatidylcholine or silymarin;Phosphatidylcholine or silymarin
10 Safety and Efficacy Study of Regulatory T Cells in Treating Autoimmune Hepatitis Unknown status NCT02704338 Phase 1, Phase 2
11 Umbilical Cord Mesenchymal Stem Cells for Patients With Autoimmune Hepatitis Unknown status NCT01661842 Phase 1, Phase 2
12 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
13 LCP-Tacro vs. Azathioprine for the Treatment of Autoimmune Hepatitis Completed NCT00608894 Phase 2 LCP-Tacro (tacrolimus);Azathioprine
14 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury Completed NCT01548690 Phase 2 Ornithine Phenylacetate
15 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
16 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
17 Liver Test Study of Using JKB-122 in AIH Patients Active, not recruiting NCT02556372 Phase 2 JKB-122
18 A Single-arm,Phase IIa,Safety and Efficacy Trial of Selected MSCs in the Treatment of Patients With PSC & AiH Not yet recruiting NCT02997878 Phase 1, Phase 2
19 Phase II AutoImmune Hepatitis Withdrawn NCT03593460 Phase 2 Synthetic PreImplantation Factor
20 sPIF CLINICAL STUDY PROTOCOL FOR AUTOIMMUNE HEPATITIS Completed NCT02239562 Phase 1 sPIF;Placebo
21 Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Completed NCT01088607 Phase 1 ursodeoxycholic acid (UDCA)
22 Plasma Exchange Combination of Immunosuppressive Regimens for Auto-immune Hepatitis Unknown status NCT02874586 Not Applicable
23 Volatile Organic Compounds (VOCs) and Liver Diseases Unknown status NCT01279356
24 SRL (Sirolimus) Withdrawal Unknown status NCT02062944 Not Applicable Sirolimus
25 Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis Unknown status NCT00160940
26 Effect of High-protein High-fiber Diet in Patients With Autoimmune Hepatitis Completed NCT01655121 Not Applicable
27 Transient Elastography in Autoimmune Hepatitis Completed NCT01905254 Not Applicable
28 "Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children" Completed NCT03069976 Not Applicable Metronidazole
29 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
30 European Safety Registry in Ulcerative Colitis (P04808) Completed NCT00705484 Standard Therapy
31 Autoimmune Diseases And Serum Anti-Nuclear Antibodies Positivity In Non-Celiac Wheat Sensitivity Patients Completed NCT02248545
32 De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation Recruiting NCT02056054
33 Biomarkers to Predict the Success of Immunosuppression Withdrawal in Autoimmune Hepatitis Recruiting NCT03711669
34 Study of the Clinical Features of Autoimmune Hepatitis Recruiting NCT02994537
35 The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis Recruiting NCT02050646 Not Applicable
36 Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Recruiting NCT02936596 Not Applicable Ursodeoxycholic acid combination of immunosuppressive agents;Ursodeoxycholic Acid
37 Swiss Autoimmune Hepatitis Cohort Study Recruiting NCT03146884
38 Canadian Network for Autoimmune Liver Disease Recruiting NCT03569826
39 Assessing Kids for Liver Inflammation and Fibrosis Using Non-invasive MRI Recruiting NCT03198104
40 MRI Based Biomarkers in Pediatric Autoimmune Liver Disease Recruiting NCT03175471
41 MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease Recruiting NCT03178630
42 The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis Recruiting NCT02461979 Not Applicable
43 Mindfulness - Based Stress Reduction and the Relationship on Inflammation in Autoimmune Hepatitis Active, not recruiting NCT02950077 Not Applicable
44 Repeatability and Reproducibility of Multiparametric MRI Active, not recruiting NCT03743272
45 EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2) Not yet recruiting NCT03444805
46 Autoimmune Hepatitis Study Terminated NCT00286663
47 Oral Budesonide in the Treatment of Patients With Primary Biliary Cirrhosis and Overlap Features of Autoimmune Hepatitis Withdrawn NCT00587119 Not Applicable Budesonide

Search NIH Clinical Center for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: hepatitis, autoimmune

Genetic Tests for Autoimmune Hepatitis

Anatomical Context for Autoimmune Hepatitis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Hepatitis:

19
Liver

MalaCards organs/tissues related to Autoimmune Hepatitis:

41
Liver, T Cells, Testes, Bone, Thyroid, Bone Marrow, Pancreas
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Autoimmune Hepatitis

Articles related to Autoimmune Hepatitis:

(show top 50) (show all 1532)
# Title Authors Year
1
Old and New Treatments for Pediatric Autoimmune Hepatitis. ( 29766815 )
2018
2
Rapid Remission of Graves' Hyperthyroidism Without Thionamides Under Immunosuppressive Treatment for Concomitant Autoimmune Hepatitis. ( 29336235 )
2018
3
Autoimmune Hepatitis in the Elderly: Diagnosis and Pharmacologic Management. ( 29971609 )
2018
4
Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function. ( 29756667 )
2018
5
A Case of Acute Autoimmune Hepatitis Superimposed on Chronic Hepatitis B Infection. ( 29805819 )
2018
6
Primary Biliary Cholangitis and Autoimmune Hepatitis. ( 29751878 )
2018
7
Leveraging Social Networking Sites for an Autoimmune Hepatitis Genetic Repository: Pilot Study to Evaluate Feasibility. ( 29348111 )
2018
8
Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved. ( 29890851 )
2018
9
Comparative efficacy and tolerability of treatments for adult autoimmune hepatitis: A systematic review and network meta-analysis. ( 29904396 )
2018
10
A case of eosinophilic annular erythema as a presenting sign for autoimmune hepatitis. ( 29387758 )
2018
11
Type 1 autoimmune hepatitis presenting with severe autoimmune neutropenia. ( 29333079 )
2018
12
Pro: Steroids can be withdrawn posttransplant in recipients with autoimmune hepatitis. ( 29923302 )
2018
13
TLR2/4 ligand-amplified liver inflammation promotes initiation of autoimmune hepatitis due to sustained IL-6/IL-12/IL-4/IL-25 expression. ( 29793131 )
2018
14
Con: Steroids should not be withdrawn in transplant recipients with autoimmune hepatitis. ( 29893056 )
2018
15
Autoimmune Hepatitis in Children. ( 29446799 )
2018
16
Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis. ( 29349620 )
2018
17
Long-term observation of acute-onset autoimmune hepatitis presenting clinically and radiologically as acute hepatitis. ( 29450869 )
2018
18
Autoimmune hepatitis induced by a single injection of interferon-I^ 1a in a patient with multiple sclerosis. ( 29845376 )
2018
19
Primary Biliary Cholangitis-A Autoimmune Hepatitis Overlap Syndrome. ( 29423670 )
2018
20
Protective effects of Punica granatum (pomegranate) peel extract on concanavalin A-induced autoimmune hepatitis in mice. ( 29428670 )
2018
21
Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans. ( 29380822 )
2018
22
Epigenetic changes and their implications in autoimmune hepatitis. ( 29383703 )
2018
23
Autoimmune hepatitis in 828 Brazilian children and adolescents: clinical and laboratory findings, histological profile, treatments, and outcomes. ( 29856944 )
2018
24
Animal models of autoimmune hepatitis. ( 29857050 )
2018
25
Hepatotoxicity of immune checkpoint inhibitors: a histology study of seven cases in comparison with autoimmune hepatitis and idiosyncratic drug-induced liver injury. ( 29403081 )
2018
26
Clinical narrative: autoimmune hepatitis. ( 29755125 )
2018
27
Two-step progression of varenicline-induced autoimmune hepatitis. ( 29383494 )
2018
28
Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1. ( 29396050 )
2018
29
De Novo Autoimmune Hepatitis Following Liver Transplantation. ( 29880369 )
2018
30
Preserved in vitro immunoreactivity in children receiving long-term immunosuppressive therapy due to inflammatory bowel disease or autoimmune hepatitis. ( 29352427 )
2018
31
Serum IL-17 level predicts inflammatory activity in patients with autoimmune hepatitis. ( 29363666 )
2018
32
Association of TNF-I+-308 Polymorphism with Susceptibility to Autoimmune Hepatitis in Tunisians. ( 29845365 )
2018
33
Autoimmune hepatitis as a complication of common variable immunodeficiency. ( 29368942 )
2018
34
Role of age in presentation, response to therapy and outcome of autoimmune hepatitis. ( 29961755 )
2018
35
Family occurrence of autoimmune hepatitis: A Danish nationwide registry-based cohort study. ( 29885414 )
2018
36
Primary cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and SjAPgren syndrome: A case report. ( 29465536 )
2018
37
A Case of SjAPgren's Syndrome Complicated with Interstitial Nephritis and Delayed Onset Autoimmune Hepatitis. ( 29731495 )
2018
38
Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients. ( 29632422 )
2018
39
Corticosteroid Therapy Improves the Outcome of Autoimmune Hepatitis-Induced Acute Liver Failure. ( 29698940 )
2018
40
Causal relationship between acute pancreatitis and methylprednisolone pulse therapy for fulminant autoimmune hepatitis: a case report and review of literature. ( 29881634 )
2018
41
An 8-Year-Old Girl with Autoimmune Hepatitis Following Aplastic Anemia. ( 30259895 )
2018
42
Autoimmune Hepatitis, Sclerosing Cholangitis, and Autoimmune Sclerosing Cholangitis or Overlap Syndrome. ( 30266157 )
2018
43
Standardization of Autoantibody Testing in Autoimmune Hepatitis. ( 30284671 )
2018
44
Health-related quality of life in patients with autoimmune hepatitis: A questionnaire survey. ( 30286131 )
2018
45
Autoimmune Hepatitis During Ledipasvir/Sofosbuvir Treatment of Hepatitis C: A Case Report. ( 30288473 )
2018
46
Inhibition of microRNA-155 attenuates concanavalin-A-induced autoimmune hepatitis by regulating Treg/Th17 cell differentiation. ( 30290123 )
2018
47
Association of STAT4, TGFβ1, SH2B3 and PTPN22 polymorphisms with autoimmune hepatitis. ( 30291855 )
2018
48
Increased Mortality Among Patients With vs Without Cirrhosis and Autoimmune Hepatitis. ( 30291909 )
2018
49
De Novo Autoimmune Hepatitis After Living Donor Liver Transplantation: A Series of 4 Cases. ( 30302049 )
2018
50
Editorial: severe outcomes are rare in pregnancy with autoimmune hepatitis. ( 30318682 )
2018

Variations for Autoimmune Hepatitis

Expression for Autoimmune Hepatitis

Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for Autoimmune Hepatitis

GO Terms for Autoimmune Hepatitis

Cellular components related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.62 CTLA4 F2 HLA-DRB1 PDCD1
2 extracellular exosome GO:0070062 9.61 DDC F2 FAS FTCD GGT1 GPT
3 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-A HLA-DQB1 HLA-DRB1
4 MHC class II protein complex GO:0042613 9.26 HLA-DQB1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-A HLA-DQB1 HLA-DRB1

Biological processes related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.7 CYP1A2 CYP2D6 GGT1
2 interferon-gamma-mediated signaling pathway GO:0060333 9.67 HLA-A HLA-DQB1 HLA-DRB1
3 immune response GO:0006955 9.63 AIRE CTLA4 FAS HLA-A HLA-DQB1 HLA-DRB1
4 long-chain fatty acid biosynthetic process GO:0042759 9.55 CYP1A2 CYP2D6
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.54 HLA-DQB1 HLA-DRB1
6 antigen processing and presentation GO:0019882 9.54 HLA-A HLA-DQB1 HLA-DRB1
7 oxidative demethylation GO:0070989 9.51 CYP1A2 CYP2D6
8 heterocycle metabolic process GO:0046483 9.48 CYP1A2 CYP2D6
9 drug catabolic process GO:0042737 9.46 CYP1A2 CYP2D6
10 monoterpenoid metabolic process GO:0016098 9.43 CYP1A2 CYP2D6
11 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.4 HLA-DQB1 HLA-DRB1
12 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.32 HLA-DQB1 HLA-DRB1
13 isoquinoline alkaloid metabolic process GO:0033076 9.26 CYP2D6 DDC
14 alkaloid metabolic process GO:0009820 8.96 CYP1A2 CYP2D6
15 drug metabolic process GO:0017144 8.8 CYP1A2 CYP2D6 TPMT

Molecular functions related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.8 HLA-A HLA-DQB1 HLA-DRB1

Sources for Autoimmune Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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