MCID: ATM011
MIFTS: 62

Autoimmune Hepatitis

Categories: Rare diseases, Gastrointestinal diseases, Liver diseases, Immune diseases, Genetic diseases, Endocrine diseases, Infectious diseases

Aliases & Classifications for Autoimmune Hepatitis

MalaCards integrated aliases for Autoimmune Hepatitis:

Name: Autoimmune Hepatitis 38 12 76 53 59 37 15
Hepatitis, Autoimmune 44 73
Autoimmune Hepatitis with Centrilobular Necrosis 12
Autoimmune Chronic Active Hepatitis 12
Autoimmune Chronic Hepatitis 53
Chronic Autoimmune Hepatitis 59
Hepatitis Autoimmune 55
Aih 53

Characteristics:

Orphanet epidemiological data:

59
autoimmune hepatitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Norway),1-5/10000 (Norway),1-9/1000000 (Sweden),1-5/10000 (New Zealand),1-9/1000000 (Spain),1-5/10000 (Spain),1-5/10000 (Sweden),1-9/1000000 (Israel),1-5/10000 (Israel),1-9/100000 (Denmark),1-5/10000 (Denmark),1-9/100000 (Singapore),1-9/100000; Age of onset: Adult;

Classifications:

Orphanet: 59  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:2048
ICD10 33 K75.4
ICD9CM 35 571.42
MeSH 44 D019693
Orphanet 59 ORPHA2137
UMLS via Orphanet 74 C0241910
ICD10 via Orphanet 34 K75.4
KEGG 37 H01685

Summaries for Autoimmune Hepatitis

NIH Rare Diseases : 53 Autoimmune hepatitis is a disease in which the body’s immune system attacks liver cells. This immune response causes inflammation of the liver, also called hepatitis. The disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. Autoimmune hepatitis likely results from a combination of autoimmunity, environmental triggers, and a genetic predisposition. It occurs more frequently in females. Treatment typically includes corticosteroids and medications that suppress the immune system. In severe cases, a liver transplant may be needed.

MalaCards based summary : Autoimmune Hepatitis, also known as hepatitis, autoimmune, is related to hepatitis and hepatitis a. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase), and among its related pathways/superpathways are NF-kappaB Signaling and Allograft rejection. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include Blood and Umbilical Cord, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that results in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia : 76 Autoimmune hepatitis, formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver... more...

Related Diseases for Autoimmune Hepatitis

Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis a
Hepatitis C Viral Hepatitis
Hepatitis D Hepatitis E

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 hepatitis 31.7 F2 GGT1 GPT SEPSECS
2 hepatitis a 30.7 CD40LG F2 GPT
3 sclerosing cholangitis 30.5 CD40LG GGT1 HLA-DRB1
4 autoimmune pancreatitis 30.5 CTLA4 HLA-DQB1 HLA-DRB1
5 anca-associated vasculitis 30.4 CTLA4 HLA-DRB1
6 hepatitis b 30.0 CTLA4 F2 GGT1 GPT
7 hepatitis e 30.0 CD40LG F2 GPT
8 celiac disease 1 30.0 CD40LG CTLA4 HLA-A HLA-DQB1
9 graves' disease 29.7 AIRE CTLA4 FAS HLA-DRB1
10 hashimoto thyroiditis 29.6 AIRE CTLA4 FAS
11 cholestasis 29.4 F2 GGT1 GPT
12 systemic lupus erythematosus 28.8 CD40LG CTLA4 HLA-DQB1 HLA-DRB1 PDCD1
13 primary biliary cirrhosis 28.6 CD40LG CTLA4 DLAT F2 GGT1 SEPSECS
14 viral hepatitis 28.6 CD40LG F2 FAS GGT1 GPT SEPSECS
15 diabetes mellitus 28.5 AIRE CTLA4 FAS HLA-A HLA-DQB1 HLA-DRB1
16 cholangitis, primary sclerosing 28.4 AIRE DLAT GGT1 GPT HLA-A SEPSECS
17 cholangitis 28.3 CD40LG DLAT F2 GGT1 GPT HLA-DRB1
18 multiple sclerosis 28.1 CTLA4 HLA-DQB1 HLA-DRB1 PDCD1
19 liver disease 27.6 DLAT F2 FAS GGT1 GPT KRT8
20 autoimmune disease 27.3 AIRE CD40LG CTLA4 FAS HLA-DQB1 HLA-DRB1
21 amelogenesis imperfecta hypomaturation type 10.9
22 limbic encephalitis with lgi1 antibodies 10.9 HLA-DQB1 HLA-DRB1
23 type 1 diabetes mellitus 12 10.9 CTLA4 HLA-DRB1
24 postherpetic neuralgia 10.9 HLA-A HLA-DRB1
25 metal allergy 10.8 HLA-DQB1 HLA-DRB1
26 focal epithelial hyperplasia 10.8 HLA-DQB1 HLA-DRB1
27 hypersomnia 10.8 HLA-DQB1 HLA-DRB1
28 lichen planopilaris 10.8 HLA-DQB1 HLA-DRB1
29 hepatoportal sclerosis 10.8 F2 GPT
30 beryllium disease 10.8 HLA-DQB1 HLA-DRB1
31 recurrent respiratory papillomatosis 10.8 HLA-DQB1 HLA-DRB1
32 chronic beryllium disease 10.7 HLA-DQB1 HLA-DRB1
33 pars planitis 10.7 HLA-A HLA-DRB1
34 caplan's syndrome 10.7 FAS HLA-A
35 anterior uveitis 10.7 CTLA4 HLA-A
36 qualitative platelet defect 10.6 F2 HLA-A
37 kwashiorkor 10.6 F2 GPT
38 lichen sclerosus 10.6 HLA-DQB1 HLA-DRB1
39 amelogenesis imperfecta, type ie 10.6 CYP2D6 FTCD SEPSECS
40 pityriasis rosea 10.6 HLA-A HLA-DQB1 HLA-DRB1
41 idiopathic bronchiectasis 10.6 HLA-A HLA-DQB1 HLA-DRB1
42 geographic tongue 10.6 HLA-A HLA-DQB1 HLA-DRB1
43 paraneoplastic pemphigus 10.6 HLA-A HLA-DQB1 HLA-DRB1
44 type 1 diabetes mellitus 17 10.6 AIRE CTLA4
45 whipple disease 10.5 HLA-DQB1 HLA-DRB1
46 type ii mixed cryoglobulinemia 10.5 FAS HLA-DQB1 HLA-DRB1
47 primary biliary cholangitis 10.5
48 autoimmune addison disease 10.5 AIRE CTLA4 HLA-DRB1
49 biliary cirrhosis, primary, 1 10.5
50 hepatic tuberculosis 10.4 F2 GGT1 GPT

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to Autoimmune Hepatitis

Symptoms & Phenotypes for Autoimmune Hepatitis

MGI Mouse Phenotypes related to Autoimmune Hepatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 FAS GGT1 AIRE HLA-DQB1 CD40LG CTLA4
2 homeostasis/metabolism MP:0005376 10 FAS GGT1 AIRE CD40LG HLA-DQB1 KRT8
3 endocrine/exocrine gland MP:0005379 9.97 FAS GGT1 AIRE CD40LG HLA-DQB1 CTLA4
4 liver/biliary system MP:0005370 9.7 FAS AIRE HLA-DQB1 CTLA4 KRT8 PDCD1
5 reproductive system MP:0005389 9.56 FAS GGT1 AIRE CD40LG HLA-DQB1 KRT8
6 respiratory system MP:0005388 9.17 FAS AIRE HLA-DQB1 CTLA4 CYP1A2 PDCD1

Drugs & Therapeutics for Autoimmune Hepatitis

Drugs for Autoimmune Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
3
Azathioprine Approved Phase 4,Phase 2,Not Applicable 446-86-6 2265
4
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
5
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
6
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
7
Mycophenolic acid Approved Phase 4 24280-93-1 446541
8 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
9 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
10 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
11 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
13 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
14 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
15 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
16 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
17 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
19 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Methylprednisolone acetate Phase 4,Phase 3,Not Applicable
22 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Not Applicable
23 Prednisolone acetate Phase 4,Phase 3,Not Applicable
24 Prednisolone hemisuccinate Phase 4,Phase 3,Not Applicable
25 Prednisolone phosphate Phase 4,Phase 3,Not Applicable
26 Anthelmintics Phase 4
27 Antimalarials Phase 4
28 Antimetabolites Phase 4,Phase 2
29 Antimetabolites, Antineoplastic Phase 4,Phase 2
30 Antiparasitic Agents Phase 4,Not Applicable
31 Antiprotozoal Agents Phase 4,Not Applicable
32 Chloroquine diphosphate Phase 4 50-63-5
33 Anti-Bacterial Agents Phase 4,Not Applicable
34 Antibiotics, Antitubercular Phase 4,Not Applicable
35 Antitubercular Agents Phase 4
36
Miconazole Approved, Investigational, Vet_approved Phase 3,Not Applicable 22916-47-8 4189
37
Budesonide Approved Phase 2, Phase 3,Not Applicable 51333-22-3 63006 5281004
38 Antiemetics Phase 3
39 Antifungal Agents Phase 3,Not Applicable
40 Autonomic Agents Phase 3,Phase 2,Not Applicable
41 Calcineurin Inhibitors Phase 3,Phase 2
42 Cyclosporins Phase 3
43 Dermatologic Agents Phase 3
44 Gastrointestinal Agents Phase 3,Phase 1,Phase 2,Not Applicable
45 Neuroprotective Agents Phase 3
46 Protective Agents Phase 3
47 Anti-Asthmatic Agents Phase 2, Phase 3,Not Applicable
48 Bronchodilator Agents Phase 2, Phase 3,Not Applicable
49 Respiratory System Agents Phase 2, Phase 3,Not Applicable
50
Etanercept Approved, Investigational Phase 1, Phase 2 185243-69-0

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Possible Role of Chloroquine to Induce a Complete Remission in the Treatment of Autoimmune Hepatitis: a Randomized Trial Completed NCT02463331 Phase 4 Chloroquine diphosphate;prednisone;azathioprine
2 CHLOROQUINE FOR MAINTENANCE REMISSION OF AUTOIMMUNE HEPATITIS Completed NCT01980745 Phase 4 Chloroquine diphosphate 250mg;Placebo
3 Mycophenolate vs Azathioprin in Autoimmune Hepatitis Completed NCT00687180 Phase 4 Treatment with mycophenolat mofetil;Treatment with azathioprin
4 Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis Recruiting NCT02900443 Phase 4 Mycophenolate mofetil;Azathioprine
5 Cyclosporine-A Versus Prednisolone for Induction of Remission in Auto-immune Hepatitis Unknown status NCT01170351 Phase 3 Cyclosporine-A
6 Budesonide 3x3mg/d Versus Prednisone in Active Autoimmune Hepatitis Completed NCT00838214 Phase 2, Phase 3 budesonide;prednisone
7 ADCC Mediated B-Cell dEpletion and BAFF-R Blockade Not yet recruiting NCT03217422 Phase 2, Phase 3
8 Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis Withdrawn NCT02878863 Phase 3 Paeoniflorin + phosphatidylcholine or silymarin;Phosphatidylcholine or silymarin
9 Umbilical Cord Mesenchymal Stem Cells for Patients With Autoimmune Hepatitis Unknown status NCT01661842 Phase 1, Phase 2
10 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
11 LCP-Tacro vs. Azathioprine for the Treatment of Autoimmune Hepatitis Completed NCT00608894 Phase 2 LCP-Tacro (tacrolimus);Azathioprine
12 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure Completed NCT01548690 Phase 2 Ornithine phenylacetate
13 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
14 Liver Test Study of Using JKB-122 in AIH Patients Recruiting NCT02556372 Phase 2 JKB-122
15 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
16 Safety and Efficacy Study of Regulatory T Cells in Treating Autoimmune Hepatitis Not yet recruiting NCT02704338 Phase 1, Phase 2
17 A Single-arm,Phase IIa,Safety and Efficacy Trial of Selected MSCs in the Treatment of Patients With PSC & AiH Not yet recruiting NCT02997878 Phase 1, Phase 2
18 sPIF CLINICAL STUDY PROTOCOL FOR AUTOIMMUNE HEPATITIS Completed NCT02239562 Phase 1 sPIF;Placebo
19 Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Completed NCT01088607 Phase 1 ursodeoxycholic acid (UDCA)
20 Volatile Organic Compounds (VOCs) and Liver Diseases Unknown status NCT01279356
21 Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis Unknown status NCT00160940
22 Effect of High-protein High-fiber Diet in Patients With Autoimmune Hepatitis Completed NCT01655121 Not Applicable
23 Transient Elastography in Autoimmune Hepatitis Completed NCT01905254 Not Applicable
24 "Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children" Completed NCT03069976 Not Applicable Metronidazole
25 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
26 Autoimmune Diseases And Serum Anti-Nuclear Antibodies Positivity In Non-Celiac Wheat Sensitivity Patients Completed NCT02248545
27 De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation Recruiting NCT02056054
28 Study of the Clinical Features of Autoimmune Hepatitis Recruiting NCT02994537
29 The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis Recruiting NCT02050646 Not Applicable
30 Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Recruiting NCT02936596 Not Applicable Ursodeoxycholic acid combination of immunosuppressive agents;Ursodeoxycholic Acid
31 Plasma Exchange Combination of Immunosuppressive Regimens for Auto-immune Hepatitis Recruiting NCT02874586 Not Applicable
32 Swiss Autoimmune Hepatitis Cohort Study Recruiting NCT03146884
33 Canadian Network for Autoimmune Liver Disease Recruiting NCT03569826
34 Assessing Kids for Liver Inflammation and Fibrosis Using Non-invasive MRI Recruiting NCT03198104
35 MRI Based Biomarkers in Pediatric Autoimmune Liver Disease Recruiting NCT03175471
36 MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease Recruiting NCT03178630
37 The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis Recruiting NCT02461979 Not Applicable
38 SRL (Sirolimus) Withdrawal Recruiting NCT02062944 Not Applicable Sirolimus
39 Mindfulness - Based Stress Reduction and the Relationship on Inflammation in Autoimmune Hepatitis Active, not recruiting NCT02950077 Not Applicable
40 EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2) Not yet recruiting NCT03444805
41 Autoimmune Hepatitis Study Terminated NCT00286663
42 Oral Budesonide in the Treatment of Patients With Primary Biliary Cirrhosis and Overlap Features of Autoimmune Hepatitis Withdrawn NCT00587119 Not Applicable Budesonide

Search NIH Clinical Center for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: hepatitis, autoimmune

Genetic Tests for Autoimmune Hepatitis

Anatomical Context for Autoimmune Hepatitis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Hepatitis:

19
Liver

MalaCards organs/tissues related to Autoimmune Hepatitis:

41
Liver, T Cells, Testes, Bone, Thyroid, Bone Marrow, B Cells
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Autoimmune Hepatitis

Articles related to Autoimmune Hepatitis:

(show top 50) (show all 1044)
# Title Authors Year
1
Old and New Treatments for Pediatric Autoimmune Hepatitis. ( 29766815 )
2018
2
Rapid Remission of Graves' Hyperthyroidism Without Thionamides Under Immunosuppressive Treatment for Concomitant Autoimmune Hepatitis. ( 29336235 )
2018
3
Autoimmune Hepatitis in the Elderly: Diagnosis and Pharmacologic Management. ( 29971609 )
2018
4
Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function. ( 29756667 )
2018
5
A Case of Acute Autoimmune Hepatitis Superimposed on Chronic Hepatitis B Infection. ( 29805819 )
2018
6
Primary Biliary Cholangitis and Autoimmune Hepatitis. ( 29751878 )
2018
7
Leveraging Social Networking Sites for an Autoimmune Hepatitis Genetic Repository: Pilot Study to Evaluate Feasibility. ( 29348111 )
2018
8
Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved. ( 29890851 )
2018
9
Comparative efficacy and tolerability of treatments for adult autoimmune hepatitis: A systematic review and network meta-analysis. ( 29904396 )
2018
10
A case of eosinophilic annular erythema as a presenting sign for autoimmune hepatitis. ( 29387758 )
2018
11
Type 1 autoimmune hepatitis presenting with severe autoimmune neutropenia. ( 29333079 )
2018
12
Pro: Steroids can be withdrawn posttransplant in recipients with autoimmune hepatitis. ( 29923302 )
2018
13
TLR2/4 ligand-amplified liver inflammation promotes initiation of autoimmune hepatitis due to sustained IL-6/IL-12/IL-4/IL-25 expression. ( 29793131 )
2018
14
Con: Steroids should not be withdrawn in transplant recipients with autoimmune hepatitis. ( 29893056 )
2018
15
Autoimmune Hepatitis in Children. ( 29446799 )
2018
16
Fatal Talaromyces marneffei Infection in a Patient with Autoimmune Hepatitis. ( 29349620 )
2018
17
Long-term observation of acute-onset autoimmune hepatitis presenting clinically and radiologically as acute hepatitis. ( 29450869 )
2018
18
Autoimmune hepatitis induced by a single injection of interferon-I^ 1a in a patient with multiple sclerosis. ( 29845376 )
2018
19
Primary Biliary Cholangitis-A Autoimmune Hepatitis Overlap Syndrome. ( 29423670 )
2018
20
Protective effects of Punica granatum (pomegranate) peel extract on concanavalin A-induced autoimmune hepatitis in mice. ( 29428670 )
2018
21
Hospitalizations for Autoimmune Hepatitis Disproportionately Affect Black and Latino Americans. ( 29380822 )
2018
22
Epigenetic changes and their implications in autoimmune hepatitis. ( 29383703 )
2018
23
Autoimmune hepatitis in 828 Brazilian children and adolescents: clinical and laboratory findings, histological profile, treatments, and outcomes. ( 29856944 )
2018
24
Animal models of autoimmune hepatitis. ( 29857050 )
2018
25
Hepatotoxicity of immune checkpoint inhibitors: a histology study of seven cases in comparison with autoimmune hepatitis and idiosyncratic drug-induced liver injury. ( 29403081 )
2018
26
Clinical narrative: autoimmune hepatitis. ( 29755125 )
2018
27
Two-step progression of varenicline-induced autoimmune hepatitis. ( 29383494 )
2018
28
Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1. ( 29396050 )
2018
29
De Novo Autoimmune Hepatitis Following Liver Transplantation. ( 29880369 )
2018
30
Preserved in vitro immunoreactivity in children receiving long-term immunosuppressive therapy due to inflammatory bowel disease or autoimmune hepatitis. ( 29352427 )
2018
31
Serum IL-17 level predicts inflammatory activity in patients with autoimmune hepatitis. ( 29363666 )
2018
32
Association of TNF-I+-308 Polymorphism with Susceptibility to Autoimmune Hepatitis in Tunisians. ( 29845365 )
2018
33
Autoimmune hepatitis as a complication of common variable immunodeficiency. ( 29368942 )
2018
34
Role of age in presentation, response to therapy and outcome of autoimmune hepatitis. ( 29961755 )
2018
35
Family occurrence of autoimmune hepatitis: A Danish nationwide registry-based cohort study. ( 29885414 )
2018
36
Primary cutaneous amyloidosis associated with autoimmune hepatitis-primary biliary cirrhosis overlap syndrome and SjAPgren syndrome: A case report. ( 29465536 )
2018
37
A Case of SjAPgren's Syndrome Complicated with Interstitial Nephritis and Delayed Onset Autoimmune Hepatitis. ( 29731495 )
2018
38
Causal relationship between acute pancreatitis and methylprednisolone pulse therapy for fulminant autoimmune hepatitis: a case report and review of literature. ( 29881634 )
2018
39
Acute Exacerbation to Autoimmune Hepatitis Mimicking Acute Viral Hepatitis-A Case Series and Review of Literature. ( 29743801 )
2018
40
Haploidentical stem cell transplantation cures autoimmune hepatitis and cerebrovascular disease in a patient with sickle cell disease. ( 29335630 )
2018
41
Autoimmune hepatitis with sclerosing cholangitis in a patient with thiopurine methyltransferase deficiency: case presentation. ( 28523321 )
2017
42
Enrichment of Genetic Variants in the Glucocorticoid Receptor Signalling Pathway in Autoimmune Hepatitis with Failure of Standard Treatment. ( 28374975 )
2017
43
Imaging of autoimmune hepatitis and overlap syndromes. ( 27999888 )
2017
44
Polyparaneoplastic Manifestations of Malignant Thymoma: A Unique Case of Myasthenia, Autoimmune Hepatitis, Pure Red Cell Aplasia, and Keratoconjunctivitis Sicca. ( 28744421 )
2017
45
A national retrospective study of paediatric end-stage liver disease as a predictor of change to second-line therapy in children with autoimmune hepatitis. ( 28199778 )
2017
46
Review article: next-generation transformative advances in the pathogenesis and management of autoimmune hepatitis. ( 28901565 )
2017
47
Autoimmune Hepatitis Associated with Immune Thrombocytopenic Purpura. ( 28090042 )
2017
48
New Presentation of Autoimmune Hepatitis with Erythema Multiforme. ( 29059460 )
2017
49
Management of Autoimmune Hepatitis in Pregnant Women. ( 28867984 )
2017
50
Treatment Response and Outcome with Two Different Prednisolone Regimens in Autoimmune Hepatitis. ( 28871464 )
2017

Variations for Autoimmune Hepatitis

Expression for Autoimmune Hepatitis

Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for Autoimmune Hepatitis

Pathways related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.29 CD40LG CTLA4 FAS PDCD1
2
Show member pathways
12.17 CD40LG CTLA4 FAS HLA-A HLA-DQB1 HLA-DRB1
3
Show member pathways
12.11 CD40LG CTLA4 FAS PDCD1
4
Show member pathways
12.05 CD40LG CTLA4 HLA-DQB1 HLA-DRB1
5
Show member pathways
11.69 CTLA4 HLA-DQB1 HLA-DRB1 PDCD1
6
Show member pathways
11.67 HLA-DQB1 HLA-DRB1 PDCD1
7 11.56 CTLA4 HLA-DQB1 HLA-DRB1
8 11.35 CTLA4 HLA-DQB1 HLA-DRB1
9 11.26 CD40LG CTLA4 HLA-A HLA-DQB1 HLA-DRB1 PDCD1
10 11.2 CD40LG CTLA4 PDCD1

GO Terms for Autoimmune Hepatitis

Cellular components related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 F2 FAS FTCD GGT1 GPT HLA-A
2 external side of plasma membrane GO:0009897 9.35 CD40LG CTLA4 F2 HLA-DRB1 PDCD1
3 ER to Golgi transport vesicle membrane GO:0012507 9.33 HLA-A HLA-DQB1 HLA-DRB1
4 MHC class II protein complex GO:0042613 9.32 HLA-DQB1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-A HLA-DQB1 HLA-DRB1

Biological processes related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.71 CD40LG FAS KRT8
2 xenobiotic metabolic process GO:0006805 9.69 CYP1A2 CYP2D6 GGT1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-DQB1 HLA-DRB1
4 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.52 HLA-DQB1 HLA-DRB1
5 antigen processing and presentation GO:0019882 9.5 HLA-A HLA-DQB1 HLA-DRB1
6 immune response GO:0006955 9.5 AIRE CD40LG CTLA4 FAS HLA-A HLA-DQB1
7 oxidative demethylation GO:0070989 9.49 CYP1A2 CYP2D6
8 heterocycle metabolic process GO:0046483 9.46 CYP1A2 CYP2D6
9 drug catabolic process GO:0042737 9.43 CYP1A2 CYP2D6
10 monoterpenoid metabolic process GO:0016098 9.4 CYP1A2 CYP2D6
11 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.37 HLA-DQB1 HLA-DRB1
12 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.26 HLA-DQB1 HLA-DRB1
13 alkaloid metabolic process GO:0009820 9.16 CYP1A2 CYP2D6
14 T cell costimulation GO:0031295 9.02 CD40LG CTLA4 HLA-DQB1 HLA-DRB1 PDCD1

Molecular functions related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.8 HLA-A HLA-DQB1 HLA-DRB1

Sources for Autoimmune Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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