AIH
MCID: ATM011
MIFTS: 66

Autoimmune Hepatitis (AIH)

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Liver diseases, Rare diseases, Skin diseases

Aliases & Classifications for Autoimmune Hepatitis

MalaCards integrated aliases for Autoimmune Hepatitis:

Name: Autoimmune Hepatitis 39 12 77 54 60 38 15 17
Hepatitis, Autoimmune 45 74
Autoimmune Hepatitis with Centrilobular Necrosis 12
Autoimmune Chronic Active Hepatitis 12
Autoimmune Chronic Hepatitis 54
Chronic Autoimmune Hepatitis 60
Hepatitis Autoimmune 56
Aih 54

Characteristics:

Orphanet epidemiological data:

60
autoimmune hepatitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Norway),1-5/10000 (Norway),1-9/1000000 (Sweden),1-5/10000 (New Zealand),1-9/1000000 (Spain),1-5/10000 (Spain),1-5/10000 (Sweden),1-9/1000000 (Israel),1-5/10000 (Israel),1-9/100000 (Denmark),1-5/10000 (Denmark),1-9/100000 (Singapore),1-9/100000; Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:2048
KEGG 38 H01685
ICD9CM 36 571.42
MeSH 45 D019693
SNOMED-CT 69 68784009
ICD10 34 K75.4
ICD10 via Orphanet 35 K75.4
UMLS via Orphanet 75 C0241910
Orphanet 60 ORPHA2137

Summaries for Autoimmune Hepatitis

NIH Rare Diseases : 54 Autoimmune hepatitis is a disease in which the body�??s immune system attacks liver cells. This immune response causes inflammation of the liver, also called hepatitis. The disease can be quite serious and, if not treated, gets worse over time, leading to cirrhosis of the liver and/or liver failure. Autoimmune hepatitis likely results from a combination of autoimmunity, environmental triggers, and a genetic predisposition. It occurs more frequently in females. Treatment typically includes corticosteroids and medications that suppress the immune system. In severe cases, a liver transplant may be needed.

MalaCards based summary : Autoimmune Hepatitis, also known as hepatitis, autoimmune, is related to hepatitis and hepatitis a. An important gene associated with Autoimmune Hepatitis is SEPSECS (Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase), and among its related pathways/superpathways are Allograft rejection and Translocation of ZAP-70 to Immunological synapse. The drugs Methylprednisolone hemisuccinate and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include Blood and Umbilical Cord, and related phenotypes are depressivity and arthritis

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that results in inflammation located in liver caused by the body's immune system attacking the liver cells.

Wikipedia : 77 Autoimmune hepatitis, formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver... more...

Related Diseases for Autoimmune Hepatitis

Diseases in the Hepatitis family:

Hepatitis C Virus Autoimmune Hepatitis
Hepatitis B Hepatitis a
Hepatitis C Viral Hepatitis
Hepatitis D Hepatitis E

Diseases related to Autoimmune Hepatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 320)
# Related Disease Score Top Affiliating Genes
1 hepatitis 31.4 F2 GGT1 GPT KRT8 SEPSECS SLC17A5
2 hepatitis a 31.4 F2 GPT SEPSECS
3 infantile liver failure syndrome 1 30.8 F2 GPT SLC17A5
4 celiac disease 1 30.8 CTLA4 HLA-A HLA-DQB1
5 acute liver failure 30.7 F2 GPT SLC17A5
6 cholangitis 30.3 DLAT F2 GGT1 GPT HLA-DRB1
7 nonalcoholic steatohepatitis 30.2 F2 GPT SLC17A5
8 hepatitis b 30.2 CTLA4 F2 GGT1 GPT SLC17A5
9 multiple sclerosis 30.1 CTLA4 HLA-DQB1 HLA-DRB1 PDCD1
10 cryptogenic cirrhosis 30.1 F2 KRT8
11 pure red-cell aplasia 30.1 HLA-A HLA-DQB1 HLA-DRB1
12 fatty liver disease 30.1 FAS GGT1 SLC17A5
13 hashimoto thyroiditis 30.0 AIRE CTLA4 FAS
14 liver cirrhosis 29.8 F2 GGT1 GPT KRT8 SLC17A5
15 systemic lupus erythematosus 29.8 CTLA4 F2 FAS HLA-DQB1 HLA-DRB1 PDCD1
16 cholangitis, primary sclerosing 29.7 AIRE DLAT GGT1 GPT HLA-A SEPSECS
17 hepatic encephalopathy 29.7 F2 GPT SLC17A5
18 cholestasis 29.7 F2 GGT1 GPT
19 viral hepatitis 29.7 F2 FAS GGT1 GPT SEPSECS SLC17A5
20 hepatic coma 29.7 F2 GPT
21 diabetes mellitus 29.4 AIRE CTLA4 FAS HLA-A HLA-DQB1 HLA-DRB1
22 vitiligo-associated multiple autoimmune disease susceptibility 1 29.3 AIRE CTLA4 PDCD1
23 diabetes mellitus, insulin-dependent 29.2 AIRE CTLA4 HLA-A HLA-DQB1 HLA-DRB1
24 autoimmune disease 29.1 AIRE CTLA4 FAS HLA-DQB1 HLA-DRB1 PDCD1
25 liver disease 28.9 DLAT F2 FAS GGT1 GOLM1 GPT
26 amelogenesis imperfecta hypomaturation type 11.1
27 primary biliary cholangitis 10.7
28 biliary cirrhosis, primary, 1 10.7
29 primary biliary cirrhosis 10.7
30 hepatitis c 10.6
31 sclerosing cholangitis 10.5
32 limbic encephalitis with lgi1 antibodies 10.4 HLA-DQB1 HLA-DRB1
33 type 1 diabetes mellitus 12 10.4 CTLA4 HLA-DRB1
34 postherpetic neuralgia 10.4 HLA-A HLA-DRB1
35 narcolepsy 2 10.4 HLA-DQB1 HLA-DRB1
36 autoimmune polyglandular syndrome type 3 10.4 HLA-DQB1 HLA-DRB1
37 hepatocellular carcinoma 10.4
38 hypersomnia 10.4 HLA-DQB1 HLA-DRB1
39 metal allergy 10.4 HLA-DQB1 HLA-DRB1
40 paraquat poisoning 10.4 GPT SLC17A5
41 lichen planopilaris 10.4 HLA-DQB1 HLA-DRB1
42 pyridoxine deficiency 10.4 GPT SLC17A5
43 hepatitis c virus 10.4
44 lupus erythematosus 10.4
45 beryllium disease 10.4 HLA-DQB1 HLA-DRB1
46 recurrent respiratory papillomatosis 10.4 HLA-DQB1 HLA-DRB1
47 anca-associated vasculitis 10.4 CTLA4 HLA-DRB1
48 narcolepsy 1 10.4 HLA-DQB1 HLA-DRB1
49 hepatoportal sclerosis 10.4 F2 GPT
50 chronic beryllium disease 10.3 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Autoimmune Hepatitis:



Diseases related to Autoimmune Hepatitis

Symptoms & Phenotypes for Autoimmune Hepatitis

Human phenotypes related to Autoimmune Hepatitis:

60 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 depressivity 60 Frequent (79-30%)
2 arthritis 60 Occasional (29-5%)
3 splenomegaly 60 Occasional (29-5%)
4 arthralgia 60 Frequent (79-30%)
5 ascites 60 Occasional (29-5%)
6 abdominal pain 60 Frequent (79-30%)
7 anxiety 60 Occasional (29-5%)
8 elevated hepatic transaminases 60 Very frequent (99-80%)
9 vitiligo 60 Occasional (29-5%)
10 thyroiditis 60 Occasional (29-5%)
11 cirrhosis 60 Occasional (29-5%)
12 inflammation of the large intestine 60 Occasional (29-5%)
13 jaundice 60 Occasional (29-5%)
14 chronic fatigue 60 Frequent (79-30%)
15 gastrointestinal hemorrhage 60 Occasional (29-5%)
16 acute hepatitis 60 Occasional (29-5%)
17 increased antibody level in blood 60 Obligate (100%)
18 spider hemangioma 60 Frequent (79-30%)
19 ulcerative colitis 60 Occasional (29-5%)
20 hepatocellular carcinoma 60 Very rare (<4-1%)
21 increased igg level 60 Obligate (100%)
22 smooth muscle antibody positivity 60 Very frequent (99-80%)
23 antineutrophil antibody positivity 60 Very frequent (99-80%)
24 antinuclear antibody positivity 60 Very frequent (99-80%)
25 liver kidney microsome type 1 antibody positivity 60 Very frequent (99-80%)
26 anti-liver cytosolic antigen type 1 antibody positivity 60 Very frequent (99-80%)
27 glomerulonephritis 60 Occasional (29-5%)
28 increased total bilirubin 60 Occasional (29-5%)
29 diffuse hepatic steatosis 60 Occasional (29-5%)
30 sclerosing cholangitis 60 Occasional (29-5%)
31 fulminant hepatitis 60 Very rare (<4-1%)
32 viral hepatitis 60 Very rare (<4-1%)

MGI Mouse Phenotypes related to Autoimmune Hepatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 AIRE CTLA4 CYP1A2 F2 FAS GGT1
2 liver/biliary system MP:0005370 9.76 AIRE CTLA4 CYP1A2 FAS GOLM1 HLA-DQB1
3 mortality/aging MP:0010768 9.73 AIRE CTLA4 CYP1A2 F2 FAS GGT1
4 respiratory system MP:0005388 9.17 AIRE CTLA4 CYP1A2 F2 FAS HLA-DQB1

Drugs & Therapeutics for Autoimmune Hepatitis

Drugs for Autoimmune Hepatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Not Applicable 2921-57-5
2
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Not Applicable 302-25-0
3
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
5
Azathioprine Approved Phase 4,Phase 2,Not Applicable 446-86-6 2265
6
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
7
chloroquine Approved, Investigational, Vet_approved Phase 4 54-05-7 2719
8
Mycophenolic acid Approved Phase 4 24280-93-1 446541
9
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Not Applicable 2920-86-7
10 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 1,Phase 2
13 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
14 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
15 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
17 Analgesics Phase 4,Phase 3,Phase 1,Phase 2
18 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 1,Phase 2
19 Immunosuppressive Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
20 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
21 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
22 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
24 Methylprednisolone Acetate Phase 4,Phase 3,Not Applicable
25 Prednisolone acetate Phase 4,Phase 3,Not Applicable
26 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
27 Protective Agents Phase 4,Phase 3
28 Autonomic Agents Phase 4,Phase 3,Phase 2,Not Applicable
29 Liver Extracts Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1
30 Antiemetics Phase 4,Phase 3
31 Neuroprotective Agents Phase 4,Phase 3
32 Antibiotics, Antitubercular Phase 4,Not Applicable
33 Anti-Bacterial Agents Phase 4,Not Applicable
34 Antiparasitic Agents Phase 4,Not Applicable
35 Chloroquine diphosphate Phase 4 50-63-5
36 Antimetabolites Phase 4,Phase 2
37 Antiprotozoal Agents Phase 4,Not Applicable
38 Anthelmintics Phase 4
39 Antimalarials Phase 4
40 Antimetabolites, Antineoplastic Phase 4,Phase 2
41 Antitubercular Agents Phase 4
42
Miconazole Approved, Investigational, Vet_approved Phase 3,Not Applicable 22916-47-8 4189
43
Budesonide Approved Phase 2, Phase 3,Not Applicable 51333-22-3 63006 5281004
44 Antifungal Agents Phase 3,Not Applicable
45 Dermatologic Agents Phase 3
46 Cyclosporins Phase 3
47 Calcineurin Inhibitors Phase 3,Phase 2
48 Anti-Asthmatic Agents Phase 2, Phase 3,Not Applicable
49 Bronchodilator Agents Phase 2, Phase 3,Not Applicable
50 Respiratory System Agents Phase 2, Phase 3,Not Applicable

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Possible Role of Chloroquine to Induce a Complete Remission in the Treatment of Autoimmune Hepatitis: a Randomized Trial Completed NCT02463331 Phase 4 Chloroquine diphosphate;prednisone;azathioprine
2 CHLOROQUINE FOR MAINTENANCE REMISSION OF AUTOIMMUNE HEPATITIS Completed NCT01980745 Phase 4 Chloroquine diphosphate 250mg;Placebo
3 Mycophenolate vs Azathioprin in Autoimmune Hepatitis Completed NCT00687180 Phase 4 Treatment with mycophenolat mofetil;Treatment with azathioprin
4 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
5 Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis Recruiting NCT02900443 Phase 4 Mycophenolate mofetil;Azathioprine
6 Cyclosporine-A Versus Prednisolone for Induction of Remission in Auto-immune Hepatitis Unknown status NCT01170351 Phase 3 Cyclosporine-A
7 Budesonide 3x3mg/d Versus Prednisone in Active Autoimmune Hepatitis Completed NCT00838214 Phase 2, Phase 3 budesonide;prednisone
8 ADCC Mediated B-Cell dEpletion and BAFF-R Blockade Recruiting NCT03217422 Phase 2, Phase 3
9 Paeoniflorin Combination of Hepatoprotective Drugs Versus Hepatoprotective Drugs Only for Auto-immune Hepatitis Withdrawn NCT02878863 Phase 3 Paeoniflorin + phosphatidylcholine or silymarin;Phosphatidylcholine or silymarin
10 Safety and Efficacy Study of Regulatory T Cells in Treating Autoimmune Hepatitis Unknown status NCT02704338 Phase 1, Phase 2
11 Umbilical Cord Mesenchymal Stem Cells for Patients With Autoimmune Hepatitis Unknown status NCT01661842 Phase 1, Phase 2
12 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
13 LCP-Tacro vs. Azathioprine for the Treatment of Autoimmune Hepatitis Completed NCT00608894 Phase 2 LCP-Tacro (tacrolimus);Azathioprine
14 Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury Completed NCT01548690 Phase 2 Ornithine Phenylacetate
15 Evaluate Safety & Immunogenicity of a Pandemic Influenza Vaccine (GSK1562902A) in Children Completed NCT00502593 Phase 2
16 A Single-arm,Phase IIa,Safety and Efficacy Trial of Selected MSCs in the Treatment of Patients With PSC & AiH Recruiting NCT02997878 Phase 1, Phase 2
17 Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Recruiting NCT01988506 Phase 2 Interleukin 2
18 Liver Test Study of Using JKB-122 in AIH Patients Active, not recruiting NCT02556372 Phase 2 JKB-122
19 Phase II AutoImmune Hepatitis Withdrawn NCT03593460 Phase 2 Synthetic PreImplantation Factor
20 sPIF CLINICAL STUDY PROTOCOL FOR AUTOIMMUNE HEPATITIS Completed NCT02239562 Phase 1 sPIF;Placebo
21 Safety and Efficacy Study of Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis Completed NCT01088607 Phase 1 ursodeoxycholic acid (UDCA)
22 Volatile Organic Compounds (VOCs) and Liver Diseases Unknown status NCT01279356
23 SRL (Sirolimus) Withdrawal Unknown status NCT02062944 Not Applicable Sirolimus
24 Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis Unknown status NCT00160940
25 Effect of High-protein High-fiber Diet in Patients With Autoimmune Hepatitis Completed NCT01655121 Not Applicable
26 Transient Elastography in Autoimmune Hepatitis Completed NCT01905254 Not Applicable
27 "Overlap Syndrome and PSC: Evaluating Role of Gut Microflora and Its Identification With Antibiotics in Children" Completed NCT03069976 Not Applicable Metronidazole
28 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
29 European Safety Registry in Ulcerative Colitis (P04808) Completed NCT00705484 Standard Therapy
30 Autoimmune Diseases And Serum Anti-Nuclear Antibodies Positivity In Non-Celiac Wheat Sensitivity Patients Completed NCT02248545
31 De Novo Autoimmune Hepatitis in Pediatric Liver Transplantation Recruiting NCT02056054
32 Biomarkers to Predict the Success of Immunosuppression Withdrawal in Autoimmune Hepatitis Recruiting NCT03711669
33 Study of the Clinical Features of Autoimmune Hepatitis Recruiting NCT02994537
34 The Role of Sodium Chloride and the Treg/Th17 Axis in Autoimmune Hepatitis Recruiting NCT02050646 Not Applicable
35 Remission Induction of Primary Biliary Cholangitis-autoimmune Hepatitis Overlap Syndrome Recruiting NCT02936596 Not Applicable Ursodeoxycholic acid combination of immunosuppressive agents;Ursodeoxycholic Acid
36 Plasma Exchange Combination of Immunosuppressive Regimens for Auto-immune Hepatitis Recruiting NCT02874586 Not Applicable
37 Swiss Autoimmune Hepatitis Cohort Study Recruiting NCT03146884
38 Canadian Network for Autoimmune Liver Disease Recruiting NCT03569826
39 Assessing Kids for Liver Inflammation and Fibrosis Using Non-invasive MRI Recruiting NCT03198104
40 MRI Based Biomarkers in Pediatric Autoimmune Liver Disease Recruiting NCT03175471
41 MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease Recruiting NCT03178630
42 The Role of the Vitamin D Receptor Gene Polymorphisms in Hepatocarcinogenesis Recruiting NCT02461979 Not Applicable
43 Mindfulness - Based Stress Reduction and the Relationship on Inflammation in Autoimmune Hepatitis Active, not recruiting NCT02950077 Not Applicable
44 Repeatability and Reproducibility of Multiparametric MRI Active, not recruiting NCT03743272
45 Use of Erythropoietin to Expand Regulatory T Cells in Autoimmune Liver Disease Enrolling by invitation NCT03842254 Early Phase 1 Erythropoietin
46 EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2) Not yet recruiting NCT03444805
47 Autoimmune Hepatitis Study Terminated NCT00286663
48 Oral Budesonide in the Treatment of Patients With Primary Biliary Cirrhosis and Overlap Features of Autoimmune Hepatitis Withdrawn NCT00587119 Not Applicable Budesonide

Search NIH Clinical Center for Autoimmune Hepatitis

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Autoimmune Hepatitis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: hepatitis, autoimmune

Genetic Tests for Autoimmune Hepatitis

Anatomical Context for Autoimmune Hepatitis

MalaCards organs/tissues related to Autoimmune Hepatitis:

42
Liver, T Cells, Testes, Kidney, Thyroid, Bone, Smooth Muscle

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Hepatitis:

20
Liver
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Autoimmune Hepatitis:
# Tissue Anatomical CompartmentCell Relevance
1 Blood Hematopoietic Bone Marrow Hematopoietic Stem Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Autoimmune Hepatitis

Articles related to Autoimmune Hepatitis:

(show top 50) (show all 2474)
# Title Authors Year
1
A review of the utility of tacrolimus in the management of adults with autoimmune hepatitis. ( 30650311 )
2019
2
Autoimmune hepatitis and complexities in management. ( 30651962 )
2019
3
Editorial: the role of vitamin D in autoimmune hepatitis. ( 30663100 )
2019
4
Editorial: the role of vitamin D in autoimmune hepatitis-authors' reply. ( 30663106 )
2019
5
Tryptophan-kynurenine profile in pediatric autoimmune hepatitis. ( 30666511 )
2019
6
Review article: stopping immunosuppressive treatment in autoimmune hepatitis (AIH): is it justified (and in whom and when)? ( 30667576 )
2019
7
Review article: unanswered clinical and research questions in autoimmune hepatitis-conclusions of the International Autoimmune Hepatitis Group Research Workshop. ( 30671977 )
2019
8
Adequacy of scoring systems in diagnosing paediatric autoimmune hepatitis: retrospective study using a control group children with Hepatitis B infection. ( 30703247 )
2019
9
Autoimmune hepatitis: current and future therapeutic options. ( 30716203 )
2019
10
Steroid Free Treatment of Autoimmune Hepatitis in Selected Children. ( 30723013 )
2019
11
Risk of autoimmune hepatitis reactivation in patients with chronic hepatitis C and autoimmune hepatitis treated with direct-acting antivirals. ( 30758316 )
2019
12
Systematic review with meta-analysis: mycophenolate mofetil as a second-line therapy for autoimmune hepatitis. ( 30761563 )
2019
13
Depression: An Overlooked Villain in Autoimmune Hepatitis? ( 30773711 )
2019
14
Racial Disparities in Presentation and Outcomes of Pediatric Autoimmune Hepatitis. ( 30802337 )
2019
15
What is the Optimal Dose of Predniso(lo)ne for Induction of Remission in Patients With Autoimmune Hepatitis? ( 30807845 )
2019
16
Long-term Clinical Outcomes in Patients with Autoimmune Hepatitis according to Treatment Response in Asian country. ( 30821090 )
2019
17
Focal Nodular Hyperplasia Mimicked Hepatocellular Carcinoma in an Autoimmune Hepatitis Patient With Regression of Cirrhosis. ( 30845888 )
2019
18
Incidence, prevalence, and causes of death of patients with autoimmune hepatitis: A nationwide register-based cohort study in Finland. ( 30850346 )
2019
19
Adoptive transfer of regulatory T cells stimulated by Allogeneic Hepatic Stellate Cells mitigates liver injury in mice with concanavalin A-induced autoimmune hepatitis. ( 30853178 )
2019
20
Secondary Hemophagocytic Lymphohistiocytosis: A Challenging Diagnosis in a Patient with Autoimmune Hepatitis. ( 30863647 )
2019
21
Letter: severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis-offender or bystander? ( 30868627 )
2019
22
Letter: severe vitamin D deficiency is a prognostic biomarker in autoimmune hepatitis-offender or bystander? Authors' reply. ( 30868634 )
2019
23
Letter to Editor: Flare of Autoimmune Hepatitis causing acute on chronic liver failure: diagnosis and response to corticosteroid therapy. ( 30873620 )
2019
24
Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model. ( 30883091 )
2019
25
Are High-dose Steroids Really Necessary in Treatment of Autoimmune Hepatitis? ( 30885885 )
2019
26
A case of severe rhabdomyolysis associated with secondary adrenal insufficiency and autoimmune hepatitis. ( 30898957 )
2019
27
Acute severe autoimmune hepatitis - Corticosteroids or liver transplantation? ( 30900368 )
2019
28
Ductular reaction in acute onset autoimmune hepatitis. ( 30901095 )
2019
29
Case Report: Acute Hepatitis E in a Pediatric Traveler Presenting with Features of Autoimmune Hepatitis: A Diagnostic and Therapeutic Challenge. ( 30350777 )
2019
30
Evolving Role of Vitamin D in Immune-Mediated Disease and Its Implications in Autoimmune Hepatitis. ( 30370494 )
2019
31
Successful DAA Treatment and Global Improvement in a Cirrhotic Patient with Concomitant HCV Infection and Autoimmune Hepatitis. ( 30386944 )
2019
32
Systematic review: diagnostic accuracy of non-invasive tests for staging liver fibrosis in autoimmune hepatitis. ( 30443702 )
2019
33
Treg/Th17 imbalance is associated with poor autoimmune hepatitis prognosis. ( 30453094 )
2019
34
Autoimmune hepatitis: Is the autoimmunity in the family? ( 30576081 )
2019
35
Association of CARD10 rs6000782 and TNF rs1799724 variants with paediatric-onset autoimmune hepatitis. ( 30581618 )
2019
36
Hellenic Association for the Study of the Liver Clinical Practice Guidelines: Autoimmune hepatitis. ( 30598587 )
2019
37
Pregnancy and Autoimmune Hepatitis: Presentation and Outcomes. ( 30616023 )
2019
38
Older Age and Disease Duration Are Highly Associated with Hepatocellular Carcinoma in Patients with Autoimmune Hepatitis. ( 30617453 )
2019
39
Chloroquine Is Effective for Maintenance of Remission in Autoimmune Hepatitis: Controlled, Double-Blind, Randomized Trial. ( 30619999 )
2019
40
Predniso(lo)ne Dosage and Chance of Remission in Patients With Autoimmune Hepatitis. ( 30625402 )
2019
41
Decreased health-related quality of life in children and adolescents with autoimmune hepatitis. ( 29331407 )
2019
42
Old and New Treatments for Pediatric Autoimmune Hepatitis. ( 29766815 )
2018
43
Rapid Remission of Graves' Hyperthyroidism Without Thionamides Under Immunosuppressive Treatment for Concomitant Autoimmune Hepatitis. ( 29336235 )
2018
44
Autoimmune Hepatitis in the Elderly: Diagnosis and Pharmacologic Management. ( 29971609 )
2018
45
Soluble Fgl2 restricts autoimmune hepatitis progression via suppressing Tc17 and conventional CD8+ T cell function. ( 29756667 )
2018
46
A Case of Acute Autoimmune Hepatitis Superimposed on Chronic Hepatitis B Infection. ( 29805819 )
2018
47
Primary Biliary Cholangitis and Autoimmune Hepatitis. ( 29751878 )
2018
48
Leveraging Social Networking Sites for an Autoimmune Hepatitis Genetic Repository: Pilot Study to Evaluate Feasibility. ( 29348111 )
2018
49
Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved. ( 29890851 )
2018
50
Comparative efficacy and tolerability of treatments for adult autoimmune hepatitis: A systematic review and network meta-analysis. ( 29904396 )
2018

Variations for Autoimmune Hepatitis

Expression for Autoimmune Hepatitis

Search GEO for disease gene expression data for Autoimmune Hepatitis.

Pathways for Autoimmune Hepatitis

GO Terms for Autoimmune Hepatitis

Cellular components related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 F2 FAS FTCD GGT1 GPT HLA-A
2 external side of plasma membrane GO:0009897 9.62 CTLA4 F2 HLA-DRB1 PDCD1
3 MHC class II protein complex GO:0042613 9.26 HLA-DQB1 HLA-DRB1
4 ER to Golgi transport vesicle membrane GO:0012507 9.13 HLA-A HLA-DQB1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 HLA-A HLA-DQB1 HLA-DRB1

Biological processes related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 xenobiotic metabolic process GO:0006805 9.69 CYP1A2 CYP2D6 GGT1
2 interferon-gamma-mediated signaling pathway GO:0060333 9.65 HLA-A HLA-DQB1 HLA-DRB1
3 immune response GO:0006955 9.63 AIRE CTLA4 FAS HLA-A HLA-DQB1 HLA-DRB1
4 long-chain fatty acid biosynthetic process GO:0042759 9.54 CYP1A2 CYP2D6
5 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.52 HLA-DQB1 HLA-DRB1
6 antigen processing and presentation GO:0019882 9.5 HLA-A HLA-DQB1 HLA-DRB1
7 oxidative demethylation GO:0070989 9.49 CYP1A2 CYP2D6
8 heterocycle metabolic process GO:0046483 9.46 CYP1A2 CYP2D6
9 drug catabolic process GO:0042737 9.43 CYP1A2 CYP2D6
10 monoterpenoid metabolic process GO:0016098 9.4 CYP1A2 CYP2D6
11 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.37 HLA-DQB1 HLA-DRB1
12 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.26 HLA-DQB1 HLA-DRB1
13 alkaloid metabolic process GO:0009820 8.96 CYP1A2 CYP2D6
14 drug metabolic process GO:0017144 8.8 CYP1A2 CYP2D6 TPMT

Molecular functions related to Autoimmune Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.96 HLA-DQB1 HLA-DRB1
2 peptide antigen binding GO:0042605 8.8 HLA-A HLA-DQB1 HLA-DRB1

Sources for Autoimmune Hepatitis

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