MCID: ATM112
MIFTS: 34

Autoimmune Hepatitis Type 1

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Liver diseases, Rare diseases, Skin diseases

Aliases & Classifications for Autoimmune Hepatitis Type 1

MalaCards integrated aliases for Autoimmune Hepatitis Type 1:

Name: Autoimmune Hepatitis Type 1 58
Aih Type 1 58

Classifications:

Orphanet: 58  
Rare hepatic diseases


External Ids:

Orphanet 58 ORPHA563576

Summaries for Autoimmune Hepatitis Type 1

MalaCards based summary : Autoimmune Hepatitis Type 1, also known as aih type 1, is related to sclerosing cholangitis and cholangitis. An important gene associated with Autoimmune Hepatitis Type 1 is HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. The drugs Immunoglobulin G and Liver Extracts have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Autoimmune Hepatitis Type 1

Diseases in the Hepatitis family:

Hepatitis C Virus Hepatitis a
Hepatitis C Viral Hepatitis
Hepatitis B Hepatitis D
Autoimmune Hepatitis Hepatitis E
Autoimmune Hepatitis Type 2 Autoimmune Hepatitis Type 1

Diseases related to Autoimmune Hepatitis Type 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 176, show less)
# Related Disease Score Top Affiliating Genes
1 sclerosing cholangitis 29.8 IL10 HLA-DRB1 GPT
2 cholangitis 29.8 IL10 HLA-DRB1 GPT
3 autoimmune hepatitis 29.5 IL4 IL10 HLA-DRB1 HLA-DQB1 GPT
4 primary biliary cirrhosis 28.4 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 GPT
5 autoimmune disease 28.4 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 BMP6
6 multiple sclerosis 28.4 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
7 thrombocytopenia 28.3 IL4 IL10 HLA-DRB3 GPT
8 nontuberculous mycobacterial lung disease 10.4 HLA-DRB1 BMP6
9 limbic encephalitis with lgi1 antibodies 10.4 HLA-DRB1 HLA-DQB1
10 achalasia, familial esophageal 10.4 HLA-DQB1 HLA-DQA1
11 autoimmune polyglandular syndrome type 3 10.4 HLA-DRB1 HLA-DQB1
12 hypersomnia 10.3 HLA-DRB1 HLA-DQB1
13 narcolepsy 2 10.3 HLA-DRB1 HLA-DQB1
14 type ii mixed cryoglobulinemia 10.3 HLA-DRB1 HLA-DQB1
15 moyamoya angiopathy 10.3 HLA-DRB1 HLA-DQB1
16 recurrent respiratory papillomatosis 10.3 HLA-DRB1 HLA-DQB1
17 apple allergy 10.3 HLA-DRB1 HLA-DQB1
18 chronic beryllium disease 10.3 HLA-DRB1 HLA-DQB1
19 podoconiosis 10.3 HLA-DQB1 HLA-DQA1
20 pediatric multiple sclerosis 10.3 HLA-DRB1 HLA-DQB1
21 osteonecrosis of the jaw 10.3 HLA-DRB1 HLA-DQB1
22 cholecystolithiasis 10.3 GPT BMP6
23 narcolepsy 1 10.3 HLA-DRB1 HLA-DQB1
24 red cell aplasia 10.3 HLA-DRB1 HLA-DQB1
25 whipple disease 10.3 HLA-DRB1 HLA-DQB1
26 eosinophilia-myalgia syndrome 10.3 HLA-DRB1 HLA-DQA1 BMP6
27 juvenile myasthenia gravis 10.2 IL10 HLA-DRB1
28 paraneoplastic pemphigus 10.2 HLA-DRB1 HLA-DQB1
29 diffuse cutaneous systemic sclerosis 10.2 ICOS HLA-DRB1
30 primary adrenal insufficiency 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
31 beryllium disease 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
32 focal epithelial hyperplasia 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
33 idiopathic bronchiectasis 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
34 oligoarticular juvenile idiopathic arthritis 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
35 alveolar echinococcosis 10.2 HLA-DRB1 HLA-DQB1
36 cervical dystonia 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
37 guillain-barre syndrome 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
38 narcolepsy 10.1 HLA-DRB1 HLA-DQB1 HLA-DQA1
39 intrahepatic cholestasis of pregnancy 10.1 HLA-DRB1 HLA-DQA1 GPT
40 discoid lupus erythematosus 10.1 IL10 HLA-DRB1
41 pure red-cell aplasia 10.1 HLA-DRB1 HLA-DQB1
42 idiopathic neutropenia 10.1 IL10 HLA-DRB1
43 liver disease 10.1
44 typhoid fever 10.1 HLA-DRB1 HLA-DQB1 GPT
45 severe cutaneous adverse reaction 10.1 HLA-DRB1 HLA-DQB1 GPT
46 pityriasis rosea 10.0 HLA-DRB3 HLA-DRB1 HLA-DQB1
47 idiopathic nephrotic syndrome 10.0 IL4 HLA-DRB1
48 sympathetic ophthalmia 10.0 IL10 HLA-DRB1 HLA-DQA1
49 african tick-bite fever 10.0 IL10 GPT
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
51 liver cirrhosis 10.0
52 autoimmune hepatitis type 2 10.0
53 mixed connective tissue disease 10.0 IL10 HLA-DRB1 HLA-DQA1
54 optic neuritis 10.0 IL10 HLA-DRB1 HLA-DQA1
55 congenital toxoplasmosis 9.9 IL10 HLA-DQB1 HLA-DQA1
56 cryoglobulinemia 9.9 IL10 HLA-DRB1 GPT
57 cytomegalovirus retinitis 9.9 IL10 HLA-DRB1 HLA-DQB1
58 cystic echinococcosis 9.9 IL10 HLA-DRB1 HLA-DQB1
59 panuveitis 9.9 IL10 HLA-DRB1 HLA-DQB1
60 calcinosis 9.9 HLA-DRB1 HLA-DQB1 HLA-DQA1 GPT
61 rheumatic disease 9.9 IL10 HLA-DRB1 BMP6
62 graft-versus-host disease 9.9 IL10 HLA-DRB1 HLA-DQB1
63 mumps 9.9 IL10 HLA-DRB1 HLA-DQB1
64 hepatocellular carcinoma 9.9
65 varicose veins 9.9
66 anemia, autoimmune hemolytic 9.9
67 amelogenesis imperfecta, type ie 9.9
68 ataxia and polyneuropathy, adult-onset 9.9
69 cholangitis, primary sclerosing 9.9
70 cryptococcal meningitis 9.9
71 esophageal varix 9.9
72 thrombocytopenia due to platelet alloimmunization 9.9
73 drug-induced hepatitis 9.9
74 hepatitis 9.9
75 hemolytic anemia 9.9
76 measles 9.9
77 evans' syndrome 9.9
78 cytokine deficiency 9.9
79 cytomegalovirus infection 9.9
80 nut allergy 9.8 IL4 IL10
81 tropical endomyocardial fibrosis 9.8 IL4 IL10
82 endomyocardial fibrosis 9.8 IL4 IL10
83 bronchopneumonia 9.8 IL10 GPT
84 opisthorchiasis 9.8 IL4 GPT
85 hypersplenism 9.8 IL4 GPT BMP6
86 ocular cicatricial pemphigoid 9.7 IL4 HLA-DRB1 HLA-DQB1
87 cicatricial pemphigoid 9.7 IL4 HLA-DRB1 HLA-DQB1
88 microscopic colitis 9.7 IL4 HLA-DRB1 HLA-DQB1
89 nickel allergic contact dermatitis 9.7 IL4 IL10
90 orofacial granulomatosis 9.7 IL4 IL10
91 loiasis 9.7 IL4 IL10
92 eales disease 9.7 IL4 IL10
93 trichinosis 9.7 IL4 IL10
94 mikulicz disease 9.7 IL4 IL10
95 acute disseminated encephalomyelitis 9.7 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
96 rheumatic fever 9.7 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
97 inflammatory bowel disease 18 9.7 IL4 IL10
98 vogt-koyanagi-harada disease 9.7 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
99 juvenile rheumatoid arthritis 9.7 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
100 bullous pemphigoid 9.7 IL4 HLA-DRB1 HLA-DQB1
101 mucocutaneous leishmaniasis 9.7 IL4 IL10
102 beta-lactam allergy 9.7 IL4 IL10
103 elephantiasis 9.7 IL4 IL10
104 lupus erythematosus 9.7 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
105 egg allergy 9.7 IL4 IL10
106 taeniasis 9.7 IL4 IL10
107 chronic conjunctivitis 9.7 IL4 IL10
108 eosinophilic meningitis 9.6 IL4 IL10
109 cow milk allergy 9.6 IL4 IL10
110 penicillin allergy 9.6 IL4 IL10
111 acute graft versus host disease 9.6 IL4 IL10
112 filarial elephantiasis 9.6 IL4 IL10
113 intestinal schistosomiasis 9.6 IL4 IL10
114 autoimmune gastritis 9.6 IL4 IL10 HLA-DRB1
115 tuberculoid leprosy 9.6 IL4 IL10 BMP6
116 allergic bronchopulmonary aspergillosis 9.6 IL4 IL10 HLA-DRB1
117 autoimmune disease of endocrine system 9.6 IL4 IL10 HLA-DRB1
118 leptospirosis 9.6 IL4 IL10 HLA-DRB1
119 latex allergy 9.6 IL4 HLA-DQB1
120 visceral leishmaniasis 9.6 IL4 IL10 HLA-DRB1
121 autoimmune disease of eyes, ear, nose and throat 9.5 IL4 IL10
122 spondyloarthropathy 9.5 IL4 IL10 BMP6
123 autoimmune disease of central nervous system 9.5 IL4 IL10 HLA-DRB1
124 ige responsiveness, atopic 9.5 IL4 IL10 CD14
125 graves' disease 9.5 IL4 HLA-DRB1 HLA-DQB1 HLA-DQA1
126 primary systemic mycosis 9.5 IL4 IL10
127 bone inflammation disease 9.5 IL4 IL10 HLA-DRB1
128 relapsing-remitting multiple sclerosis 9.5 IL4 IL10 HLA-DRB1
129 brucellosis 9.5 IL4 IL10 CD14
130 splenic disease 9.5 IL4 IL10 GPT
131 toxic shock syndrome 9.5 IL4 IL10 CD14
132 hepatitis a 9.5 IL4 IL10 GPT
133 peritonitis 9.5 IL4 IL10 CD14
134 hair disease 9.5 IL4 IL10 GPT
135 myasthenia gravis 9.5 IL4 IL10 HLA-DQB1
136 parasitic protozoa infectious disease 9.5 IL4 IL10 GPT
137 schistosomiasis 9.5 IL4 IL10 GPT
138 demyelinating disease 9.5 IL4 IL10 HLA-DRB1
139 kawasaki disease 9.5 IL4 IL10 GPT
140 allergic asthma 9.5 IL4 IL10 CD14
141 primary bacterial infectious disease 9.5 IL4 IL10 GPT
142 trypanosomiasis 9.5 IL4 IL10 GPT
143 psoriatic arthritis 9.5 IL4 IL10 HLA-DRB1
144 crohn's disease 9.4 IL4 IL10 HLA-DRB1
145 myocarditis 9.4 IL4 IL10 HLA-DQB1
146 rheumatic heart disease 9.4 IL4 IL10 HLA-DRB1 HLA-DQA1
147 leprosy 3 9.4 IL4 IL10 HLA-DRB1 HLA-DQA1
148 peripheral nervous system disease 9.4 IL4 IL10 GPT
149 dengue hemorrhagic fever 9.3 IL4 IL10 HLA-DRB1 GPT
150 dermatitis herpetiformis 9.3 IL4 IL10 HLA-DQB1 HLA-DQA1
151 toxoplasmosis 9.3 IL4 IL10 HLA-DQB1 HLA-DQA1
152 metal allergy 9.3 IL4 IL10 HLA-DRB1 HLA-DQB1
153 behcet syndrome 9.3 IL4 IL10 HLA-DRB1
154 primary progressive multiple sclerosis 9.3 IL4 IL10 HLA-DRB1 HLA-DQB1
155 pemphigus 9.3 IL4 IL10 HLA-DRB1 HLA-DQB1
156 pulmonary tuberculosis 9.3 IL4 IL10 HLA-DRB1 HLA-DQB1
157 ulcerative colitis 9.3 IL4 IL10 HLA-DRB1
158 arteriosclerosis 9.2 IL4 IL10 GPT CD14
159 drug-induced lupus erythematosus 9.2 IL4 IL10
160 connective tissue disease 9.1 IL4 IL10 HLA-DRB1 HLA-DQA1 BMP6
161 viral hepatitis 9.1 IL4 IL10 HLA-DRB1 HLA-DQA1 GPT
162 alopecia areata 9.1 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
163 hashimoto thyroiditis 9.1 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
164 rheumatoid arthritis 9.1 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
165 arthritis 9.1 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
166 viral infectious disease 9.0 IL4 IL10 GPT
167 peanut allergy 9.0 IL4 IL10 HLA-DRB1 HLA-DQB1 CD14
168 rubella 8.8 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 GPT
169 leishmaniasis 8.8 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 GPT
170 inflammatory bowel disease 8.8 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD14
171 celiac disease 1 8.7 SH2B3 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
172 diabetes mellitus, insulin-dependent 8.7 SH2B3 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
173 asthma 8.6 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD14
174 autoimmune disease of gastrointestinal tract 8.4 SH2B3 IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
175 systemic lupus erythematosus 8.3 IL4 IL10 ICOS HLA-DRB3 HLA-DRB1 HLA-DQB1
176 diabetes mellitus 8.1 SH2B3 IL4 IL10 HLA-DRB3 HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Autoimmune Hepatitis Type 1:



Diseases related to Autoimmune Hepatitis Type 1

Symptoms & Phenotypes for Autoimmune Hepatitis Type 1

GenomeRNAi Phenotypes related to Autoimmune Hepatitis Type 1 according to GeneCards Suite gene sharing:

26 (showing 27, show less)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.88 IL10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.88 HLA-DRB3 IL10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.88 HLA-DRB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.88 IL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.88 HLA-DRB1 IL10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.88 HLA-DRB3 IL10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.88 HLA-DRB1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.88 IL10
9 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.88 IL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.88 HLA-DRB1 HLA-DRB3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.88 HLA-DRB3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.88 IL10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.88 HLA-DRB1 HLA-DRB3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.88 HLA-DRB1 HLA-DRB3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.88 HLA-DRB1 HLA-DRB3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.88 IL10
17 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.88 IL10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.88 HLA-DRB3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.88 IL10
20 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.88 IL10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.88 HLA-DRB3
22 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.88 IL10
23 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.88 HLA-DRB1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.88 IL10
25 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.88 HLA-DRB1 HLA-DRB3 IL10
26 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.88 IL10
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.88 IL10

Drugs & Therapeutics for Autoimmune Hepatitis Type 1

Drugs for Autoimmune Hepatitis Type 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 4, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulin G Phase 1, Phase 2
2 Liver Extracts Phase 1, Phase 2
3 Immunoglobulins Phase 1, Phase 2
4 Antibodies Phase 1, Phase 2

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Phase 1/2 Study of UC-MSC Treatment for Evaluation the Efficacy and Safety in Patients With Autoimmune Liver Disease Unknown status NCT01661842 Phase 1, Phase 2

Search NIH Clinical Center for Autoimmune Hepatitis Type 1

Genetic Tests for Autoimmune Hepatitis Type 1

Anatomical Context for Autoimmune Hepatitis Type 1

MalaCards organs/tissues related to Autoimmune Hepatitis Type 1:

40
Liver, Bone, T Cells, Bone Marrow, Neutrophil, Smooth Muscle, Kidney

Publications for Autoimmune Hepatitis Type 1

Articles related to Autoimmune Hepatitis Type 1:

(showing 147, show less)
# Title Authors PMID Year
1
Insights on the Effects of Resveratrol and Some of Its Derivatives in Cancer and Autoimmunity: A Molecule with a Dual Activity. 61
31978952 2020
2
Autoantibodies in patients with interleukin 12 receptor beta 1 deficiency. 61
31111679 2019
3
Tryptophan-kynurenine profile in pediatric autoimmune hepatitis. 61
30666511 2019
4
Chloroquine Is Effective for Maintenance of Remission in Autoimmune Hepatitis: Controlled, Double-Blind, Randomized Trial. 61
30619999 2019
5
The clinical usage and definition of autoantibodies in immune-mediated liver disease: A comprehensive overview. 61
30366656 2018
6
Autoimmune liver disease serology in acute hepatitis E virus infection. 61
30336842 2018
7
Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1. 61
29396050 2018
8
Role of age in presentation, response to therapy and outcome of autoimmune hepatitis. 61
29961755 2018
9
Risk of malignancies in autoimmune hepatitis type 1 patients with a long-term follow-up in Japan. 61
28841782 2018
10
Autoimmune Hepatitis in Children. 61
29446799 2018
11
Anti-TNFα Treatment in Children and Adolescents With Combined Inflammatory Bowel Disease and Autoimmune Liver Disease. 61
28953529 2018
12
Influence of TBX21 T-1993C variant on autoimmune hepatitis development by Yin-Yang 1 binding. 61
29358858 2017
13
[Autoimmune hepatitis: Immunological diagnosis]. 61
28919271 2017
14
Association of autoimmune hepatitis type 1 in a child with Evans syndrome. 61
28878866 2017
15
Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1. 61
27974812 2017
16
Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis. 61
28594937 2017
17
Autoimmune hepatitis: From mechanisms to therapy. 61
27161382 2016
18
Transient Expression of Transgenic IL-12 in Mouse Liver Triggers Unremitting Inflammation Mimicking Human Autoimmune Hepatitis. 61
27511737 2016
19
Autoantibody presentation in drug-induced liver injury and idiopathic autoimmune hepatitis: the influence of human leucocyte antigen alleles. 61
27206238 2016
20
Autoimmune hepatitis and long-term disease course in children in Turkey, a single-center experience. 61
27254777 2016
21
Diagnostic Performance of an Anti-Actin Autoantibody Binding Enzyme Immunodot Blot in Autoimmune Hepatitis Type 1. 61
25425293 2016
22
[Clinical analysis of liver transplantation for autoimmune hepatitis]. 61
26743248 2015
23
A novel "humanized mouse" model for autoimmune hepatitis and the association of gut microbiota with liver inflammation. 61
26185095 2015
24
Primary complement and antibody deficiencies in autoimmune rheumatologic diseases with juvenile onset: a prospective study at two centers. 61
26590091 2015
25
Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases. 61
26220739 2015
26
In autoimmune hepatitis type 1 or the autoimmune hepatitis-sclerosing cholangitis variant defective regulatory T-cell responsiveness to IL-2 results in low IL-10 production and impaired suppression. 61
25953611 2015
27
A rare case of type-I auto-immune hepatitis and thyroiditis presenting with crescentic glomerulonephritis. 61
26354574 2015
28
Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma. 61
26207169 2015
29
Childhood Autoimmune Hepatitis in Bahrain: a Tertiary Center Experience. 61
26119196 2015
30
Hyaline droplets in Kupffer cells: a novel diagnostic clue for autoimmune hepatitis. 61
25634746 2015
31
HLA-DRB1*03:01 and HLA-DRB1*04:01 modify the presentation and outcome in autoimmune hepatitis type-1. 61
25611558 2015
32
Characteristics and outcome of autoimmune liver disease in Asian children. 61
25788179 2015
33
Autoimmune liver disease in Noonan Syndrome. 61
25595571 2015
34
Update on Autoimmune Hepatitis. 61
26357634 2015
35
Intrahepatic regulatory T cells in autoimmune hepatitis are associated with treatment response and depleted with current therapies. 61
24882050 2014
36
Genome-wide association study identifies variants associated with autoimmune hepatitis type 1. 61
24768677 2014
37
Diagnostic criteria of autoimmune hepatitis. 61
24418295 2014
38
HLA DRB1 Alleles Discriminate the Manifestation of Autoimmune Hepatitis as Type 1 or Type 2 in North Indian Population. 61
25755530 2014
39
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy from the pediatric perspective. 61
23723078 2013
40
Clinical significance of autoantibodies in autoimmune hepatitis. 61
24016388 2013
41
Autoimmune hepatitis: Contrasts and comparisons in children and adults - a comprehensive review. 61
24035197 2013
42
Anti-mitochondrial antibody positive autoimmune hepatitis triggered by EBV infection in a young girl. 61
24206743 2013
43
Involvement of (IgG and IgM)-secreting B lymphocytes in severity of autoimmune hepatitis type 1. 61
23296906 2013
44
Autoimmune hepatitis in a Jamaican cohort spanning 40 years. 61
24961867 2013
45
Hepatic hydrothorax in the absence of ascites in a child with autoimmune hepatitis: Successful management with octreotide and pleurodesis. 61
23934468 2013
46
Development of a recombinant cell-based indirect immunofluorescence assay for the determination of autoantibodies against soluble liver antigen in autoimmune hepatitis. 61
23401700 2013
47
Autoimmune hepatitis type-2 and Epstein-Barr virus infection in a toddler: art of facts or an artifact? 61
23293207 2013
48
Autoimmune hepatitis in children: an overview of the disease focusing on current therapies. 61
22495399 2012
49
Risk factors for hepatocellular carcinoma in Japanese patients with autoimmune hepatitis type 1. 61
22187167 2012
50
Liver transplantation for autoimmune hepatitis in Peru: outcomes and recurrence. 61
22345339 2012
51
Anti-α actinin antibodies as new predictors of response to treatment in autoimmune hepatitis type 1. 61
22050113 2012
52
Clinico-laboratory study on children with auto-immune hepatitis in Upper Egypt. 61
22305497 2011
53
Autoimmune hepatitis from the paediatric perspective. 61
22093323 2011
54
Warm autoimmune haemolytic anaemia and autoimmune hepatitis in an asymptomatic carrier of hepatitis B virus. 61
22204196 2011
55
Outcomes in children who underwent transplantation for autoimmune hepatitis. 61
21445922 2011
56
[Autoimmune hepatitis type 1 triggered by cytomegalovirus infection. One rare case report]. 61
20812184 2010
57
The prevalence of celiac autoantibodies in hepatitis patients. 61
20952805 2010
58
Childhood autoimmune liver disease: indications and outcome of liver transplantation. 61
20118802 2010
59
SLA/LP/tRNP((Ser)Sec) antigen in autoimmune hepatitis: identification of the native protein in human hepatic cell extract. 61
19683415 2010
60
Incidence of adult form of autoimmune hepatitis in Valencia (Spain). 61
20163033 2009
61
Autoantibodies and their antigens in autoimmune hepatitis. 61
19675997 2009
62
Autoimmune hepatitis. 61
19561543 2009
63
Autoimmune hepatitis in children: what is different from adult AIH? 61
19676002 2009
64
Smooth muscle autoantibodies with F-actin specificity. 61
19232552 2009
65
Agranulocytosis at first presentation of autoimmune hepatitis type-1. 61
19359983 2009
66
Autoimmune diseases of the liver and biliary tract and overlap syndromes in childhood. 61
19212308 2009
67
Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression? 61
19301087 2009
68
Chronic autoimmune hepatitis with Epstein-Barr virus superinfection: a case report and review of literature. 61
19102393 2008
69
Development of autoimmune hepatitis type 1 after pulsed methylprednisolone therapy for multiple sclerosis: a case report. 61
18803363 2008
70
An actin-myosin functional assay for analysis of smooth muscle (anti-microfilament) autoantibodies in human plasma. 61
18691595 2008
71
Bone marrow findings in patients with autoimmune liver diseases. 61
18205770 2008
72
Autoimmune paediatric liver disease. 61
18528933 2008
73
Anti-alpha-actinin antibodies cross-react with anti-ssDNA antibodies in active autoimmune hepatitis. 61
18197482 2008
74
Identification of plasma membrane autoantigens in autoimmune hepatitis type 1 using a proteomics tool. 61
18306218 2008
75
Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: a nationwide study. 61
18609163 2008
76
The N-terminal of human UGT1A6 is on the outside, as evidenced by ELISA with autoantibody in autoimmune hepatitis sera. 61
19356052 2007
77
Serious liver disease induced by infliximab. 61
16547695 2007
78
A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1. 61
17256726 2007
79
Association between HLA class II alleles and autoimmune hepatitis type 1 in Thai patients. 61
17722299 2006
80
Double reactivity against actin and alpha-actinin defines a severe form of autoimmune hepatitis type 1. 61
17001515 2006
81
Type 1 autoimmune hepatitis in Taiwan: diagnosis using the revised criteria of the International Autoimmune Hepatitis Group. 61
17053960 2006
82
Genetic association of autoimmune hepatitis and human leucocyte antigen in German patients. 61
17006990 2006
83
Antibodies to filamentous actin (F-actin) in type 1 autoimmune hepatitis. 61
16505279 2006
84
Autoimmune hepatitis type 1 and primary biliary cirrhosis have distinct bone marrow cytokine production. 61
16242912 2005
85
[Autoimmune chronic active hepatitis: anatomoclinic's study of 50 patients]. 61
16137797 2005
86
Autoimmune hepatitis type 1: safety and efficacy of prolonged medical therapy. 61
15998423 2005
87
Diagnostic value of anti-F-actin antibodies in a French multicenter study. 61
16014542 2005
88
Markers of cell activation and apoptosis in bone marrow mononuclear cells of patients with autoimmune hepatitis type 1 and primary biliary cirrhosis. 61
15710223 2005
89
Clinical features and biochemical data of Caucasian children at diagnosis of autoimmune hepatitis. 61
15725580 2005
90
Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2. 61
15747502 2005
91
Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease. 61
15679907 2004
92
High levels of autoantibodies against drug-metabolizing enzymes in SLA/LP-positive AIH-1 sera. 61
15621574 2004
93
Autoimmune hepatitis. 61
15722981 2004
94
Autoimmune hepatitis in children. 61
15128490 2004
95
[Incidence and prevalence of autoimmune hepatitis in the area of the Hospital de Sagunto (Spain)]. 61
15056409 2004
96
Long-term outcome of liver transplantation for autoimmune hepatitis. 61
15108772 2004
97
[Autoantibodies characteristic for autoimmune hepatitis found in chronic hepatitis C]. 61
15114784 2003
98
Hemopoietic progenitor cells and bone marrow stromal cells in patients with autoimmune hepatitis type 1 and primary biliary cirrhosis. 61
14568247 2003
99
Low frequency of anti-SLA/LP autoantibody in Japanese adult patients with autoimmune liver diseases: analysis with recombinant antigen assay. 61
12892738 2003
100
Cytotoxic T lymphocyte antigen-4 gene polymorphisms do not confer susceptibility to autoimmune hepatitis types 1 and 2 in Brazil. 61
12873588 2003
101
Fine specificity and subclasses of IgG anti-actin autoantibodies differ in health and disease. 61
12791319 2003
102
Increased carbohydrate-deficient transferrin of unknown etiology in a 15-year-old male patient with autoimmune hepatitis type 1. 61
12766022 2003
103
Identification of rat targets of anti-soluble liver antigen autoantibodies by serologic proteome analysis. 61
12651817 2003
104
Autoimmune hepatitis type 1 after Epstein-Barr virus infection. 61
12690282 2003
105
Identification of beta-subunit of bacterial RNA-polymerase--a non-species-specific bacterial protein--as target of antibodies in primary biliary cirrhosis. 61
12757171 2003
106
Organ and non-organ specific autoantibody titres and IgG levels as markers of disease activity: a longitudinal study in childhood autoimmune liver disease. 61
12765477 2002
107
[Autoimmune hepatitis and overlap syndrome: diagnosis]. 61
12233264 2002
108
Autoantibodies and defined target autoantigens in autoimmune hepatitis: an overview. 61
12144908 2002
109
[A histologic variant of autoimmune hepatitis with zonal necrosis]. 61
12154504 2002
110
Antibodies to conformational epitopes of soluble liver antigen define a severe form of autoimmune liver disease. 61
11870381 2002
111
Therapeutic effects of azathioprine in combination with low-dose prednisolone in patients with intractable autoimmune hepatitis type 1. 61
11779096 2001
112
CTLA-4/CD 28 region polymorphisms in children from families with autoimmune hepatitis. 61
11756004 2001
113
[Mushroom poisoning in an autoimmune hepatitis patient]. 61
12092242 2001
114
Autoimmune hepatitis in Brazilian patients is not linked to tumor necrosis factor alpha polymorphisms at position -308. 61
11495038 2001
115
Autoimmune regulator AIRE: evidence for genetic differences between autoimmune hepatitis and hepatitis as part of the autoimmune polyglandular syndrome type 1. 61
11343230 2001
116
Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases. 61
11343231 2001
117
Disease association, origin, and clinical relevance of autoantibodies to the glycolytic enzyme enolase. 61
11288754 2001
118
Analysis of HLA haplotypes in autoimmune hepatitis type 1: identifying the major susceptibility locus. 61
11182227 2001
119
Histopathologic comparison of anti-mitochondrial antibody-positive primary biliary cirrhosis and autoimmune cholangiopathy. 61
11137479 2001
120
A spectrum of histopathologic findings in autoimmune liver disease. 61
11068543 2000
121
Are antibodies to carbonic anhydrase II specific for anti-mitochondrial antibody-negative primary biliary cirrhosis? 61
11117577 2000
122
Autoantibodies associated with acute rejection after liver transplantation for type-2 autoimmune hepatitis. 61
10905602 2000
123
Autoimmune hepatitis. 61
10728804 2000
124
Anti-neutrophil cytoplasm autoantibodies (ANCA) in autoimmune liver diseases. 61
10626156 1999
125
Genetic heterogeneity in susceptibility to autoimmune hepatitis types 1 and 2. 61
10406258 1999
126
Auto-antibodies in hepatitis C. 61
10424245 1999
127
High prevalence of antibodies to calreticulin of the IgA class in primary biliary cirrhosis: a possible role of gut-derived bacterial antigens in its aetiology? 61
10440614 1999
128
[Autoimmune hepatitis and/or hepatitis C]. 61
10500434 1999
129
[Autoimmune hepatitis. Clinical characteristics and response to treatment in a series of 49 spanish patients]. 61
9844274 1998
130
Clinical subgroup of autoimmune hepatitis type 1 sustaining remission without additional drugs. 61
9840126 1998
131
Different HLA profiles confer susceptibility to autoimmune hepatitis type 1 and 2. 61
9707090 1998
132
GH and zinc treatments for short stature caused by steroid treatments in a young patient with autoimmune hepatitis (type 1). 61
9790255 1998
133
Clinical manifestations and immunological features of primary Sjögren's syndrome with liver involvement: analysis of thirty cases. 61
10374420 1998
134
Subfulminant hepatic failure in autoimmune hepatitis type 1: an unusual form of presentation. 61
9314137 1997
135
Ultrasound-detected abdominal lymphadenopathy in chronic hepatitis C: high frequency and relationship with viremia. 61
9075652 1997
136
Antineutrophil nuclear antibodies (ANNA) in primary biliary cirrhosis: their prevalence and antigen specificity. 61
9066101 1997
137
Actin is a target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis type-1. 61
9148020 1997
138
Autoimmune hepatitis type 1 after measles. 61
8947001 1996
139
Identification of cyclin A as a molecular target of antinuclear antibodies (ANA) in hepatic and non-hepatic autoimmune diseases. 61
9007714 1996
140
Detection on immunoblot of new proteins from the microsomal fraction recognized by anti-liver-kidney microsome antibodies type 1. 61
8811045 1996
141
Etiopathogenetic role of hepatitis C virus in mixed cryoglobulinemia, chronic liver diseases and lymphomas. 61
8730494 1995
142
Segregation of pANCA antigenic recognition by DNase treatment of neutrophils: ulcerative colitis, type 1 autoimmune hepatitis, and primary sclerosing cholangitis. 61
8576315 1995
143
Occurrence of antibody against rat hepatic sinusoidal endothelial cells in sera of patients with autoimmune hepatitis. 61
7781435 1995
144
Immunogenetics of chronic liver diseases. 61
8194717 1994
145
[Autoimmunity and HCV]. 61
8290791 1993
146
Anti-GOR and hepatitis C virus in autoimmune liver diseases. 61
1346282 1992
147
[Autoimmune hepatitis type 1 revealed during treatment with interferon]. 61
1426834 1992

Variations for Autoimmune Hepatitis Type 1

Expression for Autoimmune Hepatitis Type 1

Search GEO for disease gene expression data for Autoimmune Hepatitis Type 1.

Pathways for Autoimmune Hepatitis Type 1

Pathways related to Autoimmune Hepatitis Type 1 according to GeneCards Suite gene sharing:

(showing 33, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 IL4 IL10 ICOS HLA-DRB3 HLA-DRB1 HLA-DQB1
2
Show member pathways
13.29 ICOS HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD14
3
Show member pathways
13.21 IL4 IL10 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
4
Show member pathways
13.1 IL4 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD14
5
Show member pathways
12.79 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
6
Show member pathways
12.79 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1 CARD10
7
Show member pathways
12.66 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
8
Show member pathways
12.65 IL4 IL10 ICOS HLA-DRB3 HLA-DRB1 HLA-DQB1
9 12.63 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
10
Show member pathways
12.48 SH2B3 IL4 IL10 ICOS
11
Show member pathways
12.47 IL4 IL10 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
12
Show member pathways
12.42 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
13
Show member pathways
12.36 IL4 IL10 ICOS HLA-DRB3 HLA-DRB1 HLA-DQB1
14
Show member pathways
12.3 ICOS HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
15
Show member pathways
12.25 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
16 12.24 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
17
Show member pathways
12.13 ICOS HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
18 12.06 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD14
19 12 ICOS HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
20 11.94 SH2B3 IL4 IL10 CD14
21
Show member pathways
11.91 IL4 IL10 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
22
Show member pathways
11.9 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
23 11.87 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
24 11.86 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
25 11.81 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
26 11.7 IL10 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
27 11.69 IL4 IL10 ICOS
28 11.69 IL10 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD14
29 11.66 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
30
Show member pathways
11.66 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
31 11.22 IL4 IL10 HLA-DRB1
32 11.1 IL4 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD14
33 11.06 IL4 IL10

GO Terms for Autoimmune Hepatitis Type 1

Cellular components related to Autoimmune Hepatitis Type 1 according to GeneCards Suite gene sharing:

(showing 9, show less)
# Name GO ID Score Top Affiliating Genes
1 lysosomal membrane GO:0005765 9.76 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
2 endosome membrane GO:0010008 9.73 HLA-DRB1 HLA-DQB1 HLA-DQA1 CD14
3 trans-Golgi network membrane GO:0032588 9.71 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
4 endocytic vesicle membrane GO:0030666 9.67 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
5 ER to Golgi transport vesicle membrane GO:0012507 9.62 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
6 transport vesicle membrane GO:0030658 9.56 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.46 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.26 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
9 MHC class II protein complex GO:0042613 8.92 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1

Biological processes related to Autoimmune Hepatitis Type 1 according to GeneCards Suite gene sharing:

(showing 15, show less)
# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.67 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.56 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
3 positive regulation of cytokine secretion GO:0050715 9.55 IL10 CD14
4 response to magnesium ion GO:0032026 9.54 CD14 BMP6
5 response to molecule of bacterial origin GO:0002237 9.52 IL10 CD14
6 positive regulation of MHC class II biosynthetic process GO:0045348 9.51 IL4 IL10
7 antigen processing and presentation GO:0019882 9.5 HLA-DRB1 HLA-DQB1 HLA-DQA1
8 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.49 IL4 IL10
9 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.48 HLA-DRB1 HLA-DQB1
10 type 2 immune response GO:0042092 9.46 IL4 IL10
11 regulation of isotype switching GO:0045191 9.43 IL4 IL10
12 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.4 HLA-DRB1 HLA-DQB1
13 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.33 HLA-DRB1 HLA-DQB1 HLA-DQA1
14 interferon-gamma-mediated signaling pathway GO:0060333 9.26 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
15 immune response GO:0006955 9.17 IL4 IL10 ICOS HLA-DRB1 HLA-DQB1 HLA-DQA1

Molecular functions related to Autoimmune Hepatitis Type 1 according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 IL4 IL10 BMP6
2 peptide antigen binding GO:0042605 9.26 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1
3 MHC class II receptor activity GO:0032395 8.92 HLA-DRB3 HLA-DRB1 HLA-DQB1 HLA-DQA1

Sources for Autoimmune Hepatitis Type 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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