MCID: ATM022
MIFTS: 43

Autoimmune Myocarditis

Categories: Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Autoimmune Myocarditis

MalaCards integrated aliases for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 53

Classifications:



Summaries for Autoimmune Myocarditis

NIH Rare Diseases : 53 Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended.

MalaCards based summary : Autoimmune Myocarditis is related to rheumatic heart disease and autoimmune disease. An important gene associated with Autoimmune Myocarditis is IFNG (Interferon Gamma), and among its related pathways/superpathways are IL-2 Pathway and Immune response NFAT in immune response. Affiliated tissues include heart, t cells and monocytes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Autoimmune Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 rheumatic heart disease 30.0 IL4 TNF
2 autoimmune disease 29.8 IFNG IL4 TNF
3 systemic lupus erythematosus 29.2 IFNG IL4 SPP1 TNF
4 myocarditis 11.1
5 dilated cardiomyopathy 10.3
6 conjunctivitis 10.2 IFNG IL4
7 staphylococcal toxic shock syndrome 10.1 IFNG TNF
8 hyperlucent lung 10.1 IFNG IL4
9 b-cell growth factor 10.1 IFNG IL4
10 trichosporonosis 10.1 IFNG TNF
11 nickel allergic contact dermatitis 10.1 IFNG IL4
12 chronic beryllium disease 10.1 IFNG TNF
13 baylisascariasis 10.1 IFNG IL4
14 penicillin allergy 10.1 IFNG IL4
15 atopic keratoconjunctivitis 10.1 IFNG IL4
16 cardiac sarcoidosis 10.1 IFNG TNF
17 crustacean allergy 10.1 IFNG IL4
18 miliary tuberculosis 10.1 IFNG TNF
19 chronic graft versus host disease 10.1 IFNG TNF
20 clonorchiasis 10.1 IFNG TNF
21 crohn's colitis 10.1 IFNG TNF
22 meconium aspiration syndrome 10.1 IFNG TNF
23 central nervous system vasculitis 10.1 IFNG TNF
24 soft tissue sarcoma 10.1 IFNG TNF
25 tuberculous peritonitis 10.1 IFNG TNF
26 toxic oil syndrome 10.1 IFNG IL4
27 intermediate uveitis 10.1 IFNG TNF
28 urinary schistosomiasis 10.1 IFNG IL4
29 folliculitis 10.1 IFNG IL4
30 hypersplenism 10.1 IFNG IL4
31 hyper ige syndrome 10.1 IFNG IL4
32 cytomegalovirus retinitis 10.1 IFNG TNF
33 buruli ulcer 10.1 IFNG IL4
34 posterior uveitis 10.1 IFNG TNF
35 hemorrhagic fever 10.1 IFNG TNF
36 erythema multiforme 10.1 IFNG TNF
37 pleural tuberculosis 10.1 IFNG TNF
38 spotted fever 10.1 IFNG TNF
39 hematopoietic stem cell transplantation 10.1 IFNG TNF
40 aseptic meningitis 10.1 IFNG TNF
41 cryptococcosis 10.1 IFNG IL4
42 plasmodium vivax malaria 10.1 IFNG TNF
43 vernal conjunctivitis 10.1 IFNG IL4
44 congenital cytomegalovirus 10.1 PPARG TNF
45 proliferative glomerulonephritis 10.1 IFNG IL4
46 paranasal sinus disease 10.1 IFNG IL4
47 hypersensitivity reaction type iv disease 10.1 IFNG TNF
48 hepatitis e 10.1 IFNG TNF
49 lepromatous leprosy 10.1 IFNG TNF
50 allergic conjunctivitis 10.1 IFNG IL4

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to Autoimmune Myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

MGI Mouse Phenotypes related to Autoimmune Myocarditis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 IFNG IL4 NPPA PPARG SPP1 TNF
2 homeostasis/metabolism MP:0005376 9.95 IFNG IL4 NPPA PPARG SPP1 TNF
3 cardiovascular system MP:0005385 9.92 IFNG NPPA PPARG SPP1 TNF
4 integument MP:0010771 9.85 IFNG IL4 PPARG SPP1 TNF
5 liver/biliary system MP:0005370 9.83 IFNG IL4 PPARG SPP1 TNF
6 craniofacial MP:0005382 9.81 IFNG IL4 SPP1 TNF
7 muscle MP:0005369 9.8 IFNG NPPA PPARG SPP1 TNF
8 neoplasm MP:0002006 9.67 IFNG PPARG SPP1 TNF
9 renal/urinary system MP:0005367 9.65 IFNG IL4 NPPA PPARG SPP1
10 no phenotypic analysis MP:0003012 9.62 IFNG IL4 PPARG TNF
11 reproductive system MP:0005389 9.55 IFNG IL4 PPARG SPP1 TNF
12 respiratory system MP:0005388 9.26 IFNG IL4 SPP1 TNF
13 skeleton MP:0005390 9.02 IFNG IL4 PPARG SPP1 TNF

Drugs & Therapeutics for Autoimmune Myocarditis

Search Clinical Trials , NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

Anatomical Context for Autoimmune Myocarditis

MalaCards organs/tissues related to Autoimmune Myocarditis:

41
Heart, T Cells, Monocytes, Bone, B Cells, Lung, Thyroid

Publications for Autoimmune Myocarditis

Articles related to Autoimmune Myocarditis:

(show top 50) (show all 405)
# Title Authors Year
1
Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [<sup>18</sup>F]Fluoromethyl-PBR28 and [<sup>18</sup>F]CB251. ( 29342117 )
2018
2
Urinary candidate biomarkers in an experimental autoimmune myocarditis rat model. ( 29524647 )
2018
3
FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats. ( 29128901 )
2018
4
The dynamic changes in myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 29305900 )
2018
5
Reg3I^ from cardiomyocytes regulated macrophage migration, proliferation and functional skewing in experimental autoimmune myocarditis. ( 29755853 )
2018
6
Autoimmune Myocarditis Caused by Immune Checkpoint Inhibitors Treated With Antithymocyte Globulin. ( 29965858 )
2018
7
Acute autoimmune myocarditis and hepatitis due to ipilimumab monotherapy for malignant melanoma. ( 29444608 )
2018
8
Fatal autoimmune myocarditis with anti-PD-L1 and tyrosine kinase inhibitor therapy for renal cell cancer. ( 30017380 )
2018
9
Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats. ( 30024944 )
2018
10
TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance. ( 30046376 )
2018
11
Cardiosphere-Derived Cells Attenuate Inflammation, Preserve Systolic Function, and Prevent Adverse Remodeling in Rat Hearts With Experimental Autoimmune Myocarditis. ( 30060693 )
2018
12
Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis. ( 30102319 )
2018
13
The Inflammatory Transcription Factor C/EBPβ Plays a Critical Role in Cardiac Fibroblast Differentiation and a Rat Model of Cardiac Fibrosis Induced by Autoimmune Myocarditis. ( 30305575 )
2018
14
Androgen receptor regulates cardiac fibrosis in mice with experimental autoimmune myocarditis by increasing microRNA-125b expression. ( 30340830 )
2018
15
Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis. ( 30349538 )
2018
16
PPARα suppresses Th17 cell differentiation through IL-6/STAT3 /RORγt pathway in experimental autoimmune myocarditis. ( 30557558 )
2018
17
Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. ( 28903333 )
2017
18
Carvedilol Inhibits Matrix Metalloproteinase-2 Activation in Experimental Autoimmune Myocarditis: Possibilities of Cardioprotective Application. ( 28854816 )
2017
19
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. ( 27922195 )
2017
20
I^1-Adrenergic Receptor Contains Multiple IA<sup>k</sup>and IE<sup>k</sup>Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice. ( 29209317 )
2017
21
Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. ( 28474508 )
2017
22
Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. ( 28246012 )
2017
23
Branched chain I+-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. ( 28597552 )
2017
24
Natural products with anti-inflammatory and immunomodulatory activities against autoimmune myocarditis. ( 28757189 )
2017
25
Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis. ( 28485792 )
2017
26
Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 28178619 )
2017
27
Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-I_B and PI3K/Akt signaling pathway in mice. ( 28485793 )
2017
28
Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation. ( 28772040 )
2017
29
The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis. ( 28618428 )
2017
30
Angiotensin II-C-C chemokine receptor2/5 axis-dependent monocyte/macrophage recruitment contributes to progression of experimental autoimmune myocarditis. ( 29052263 )
2017
31
Regulation of autoimmune myocarditis by host responses to the microbiome. ( 28822770 )
2017
32
A humanized HLA-DR4 mouse model for autoimmune myocarditis. ( 28431892 )
2017
33
Chronic myocarditis with a long clinical course: Report of an autopsy case of probable autoimmune myocarditis. ( 28875521 )
2017
34
Oleuropein prevents the development of experimental autoimmune myocarditis in rats. ( 28525856 )
2017
35
Cholecalciterol cholesterol emulsion attenuates experimental autoimmune myocarditis in mice via inhibition of the pyroptosis signaling pathway. ( 28887037 )
2017
36
FGL2 deteriorates cardiac function in experimental autoimmune myocarditis rats through regulation of PD-1 and inflammatory cytokines. ( 28892130 )
2017
37
The protective effects of taurine on experimental autoimmune myocarditis. ( 28485791 )
2017
38
Novel CMR techniques enable detection of even mild autoimmune myocarditis in a patient with systemic lupus erythematosus. ( 28321496 )
2017
39
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. ( 26772776 )
2016
40
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. ( 27440853 )
2016
41
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. ( 27501378 )
2016
42
11C-methionine PET of myocardial inflammation in a rat model of experimental autoimmune myocarditis. ( 27390159 )
2016
43
Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice. ( 26660726 )
2016
44
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. ( 27615269 )
2016
45
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. ( 27099262 )
2016
46
Noninvasive Contrast-Enhanced Ultrasound Molecular Imaging Detects Myocardial Inflammatory Response in Autoimmune Myocarditis. ( 27502060 )
2016
47
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model. ( 27044832 )
2016
48
Drugs Targeting the Canonical NF-I_B Pathway to Treat Viral and Autoimmune Myocarditis. ( 26696258 )
2016
49
Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice. ( 27184135 )
2016
50
Recent advances in the management of autoimmune myocarditis: insights from animal studies. ( 26696255 )
2016

Variations for Autoimmune Myocarditis

Expression for Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for Autoimmune Myocarditis

Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 IFNG IL4 SPP1 TNF
2
Show member pathways
12.4 IFNG IL4 TNF
3
Show member pathways
12.34 IFNG IL4 TNF
4 12.3 IFNG IL4 TNF
5
Show member pathways
12.26 IFNG IL4 TNF
6
Show member pathways
12.17 IFNG IL4 TNF
7
Show member pathways
12.08 IFNG IL4 TNF
8
Show member pathways
12.07 IFNG IL4 TNF
9
Show member pathways
12.01 IFNG IL4 TNF
10
Show member pathways
11.98 IFNG IL4 TNF
11
Show member pathways
11.92 IFNG IL4 TNF
12 11.79 IFNG PPARG TNF
13
Show member pathways
11.77 IFNG IL4 TNF
14 11.73 IFNG IL4 TNF
15 11.7 IFNG IL4 TNF
16 11.54 IFNG TNF
17 11.51 IFNG IL4 TNF
18 11.49 PPARG TNF
19
Show member pathways
11.47 IFNG TNF
20
Show member pathways
11.45 IFNG TNF
21 11.38 IL4 SPP1 TNF
22 11.37 IFNG TNF
23
Show member pathways
11.35 IFNG TNF
24 11.34 IL4 TNF
25 11.34 IFNG TNF
26 11.32 IFNG TNF
27 11.32 IFNG TNF
28 11.31 IFNG SPP1 TNF
29 11.3 IFNG IL4
30 11.15 IFNG SPP1 TNF
31 11.14 IFNG TNF
32
Show member pathways
11.14 IFNG IL4 PPARG TNF
33 11.11 IFNG IL4
34 10.99 IFNG IL4
35 10.94 IFNG IL4 TNF
36 10.89 PPARG TNF
37 10.79 IFNG IL4 TNF
38 10.78 IFNG IL4 PPARG TNF

GO Terms for Autoimmune Myocarditis

Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 IFNG IL4 NPPA SPP1 TNF
2 extracellular space GO:0005615 9.02 IFNG IL4 NPPA SPP1 TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.73 IFNG IL4 TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.67 IL4 PPARG SPP1 TNF
3 negative regulation of transcription, DNA-templated GO:0045892 9.62 IFNG IL4 PPARG TNF
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IFNG IL4
5 regulation of insulin secretion GO:0050796 9.58 IFNG TNF
6 regulation of blood pressure GO:0008217 9.57 NPPA PPARG
7 humoral immune response GO:0006959 9.55 IFNG TNF
8 positive regulation of protein localization to plasma membrane GO:1903078 9.54 IFNG TNF
9 extrinsic apoptotic signaling pathway GO:0097191 9.52 IFNG TNF
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.51 IFNG TNF
11 negative regulation of smooth muscle cell proliferation GO:0048662 9.49 IFNG PPARG
12 positive regulation of protein complex assembly GO:0031334 9.48 IFNG TNF
13 protein import into nucleus, translocation GO:0000060 9.46 IFNG TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.43 IFNG TNF
15 response to organic substance GO:0010033 9.43 PPARG SPP1 TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.4 IFNG TNF
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IFNG TNF
18 regulation of signaling receptor activity GO:0010469 9.02 IFNG IL4 NPPA SPP1 TNF
19 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 IFNG TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IFNG IL4 SPP1 TNF

Sources for Autoimmune Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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