MCID: ATM022
MIFTS: 39

Autoimmune Myocarditis

Categories: Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Autoimmune Myocarditis

MalaCards integrated aliases for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 54

Classifications:



Summaries for Autoimmune Myocarditis

NIH Rare Diseases : 54 Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended.

MalaCards based summary : Autoimmune Myocarditis is related to myocarditis and rere-related disorders. An important gene associated with Autoimmune Myocarditis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Immune response NFAT in immune response and NF-kappaB Signaling. Affiliated tissues include heart, t cells and monocytes, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Autoimmune Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 myocarditis 11.1
2 rere-related disorders 10.3
3 dilated cardiomyopathy 10.3
4 staphylococcal toxic shock syndrome 10.2 IFNG TNF
5 toxic shock syndrome 10.2 IFNG TNF
6 trichosporonosis 10.2 IFNG TNF
7 chronic beryllium disease 10.2 IFNG TNF
8 scleritis 10.2 IFNG TNF
9 miliary tuberculosis 10.2 IFNG TNF
10 chronic graft versus host disease 10.2 IFNG TNF
11 clonorchiasis 10.2 IFNG TNF
12 microscopic colitis 10.2 IFNG TNF
13 crohn's colitis 10.2 IFNG TNF
14 meconium aspiration syndrome 10.1 IFNG TNF
15 central nervous system vasculitis 10.1 IFNG TNF
16 soft tissue sarcoma 10.1 IFNG TNF
17 tuberculous peritonitis 10.1 IFNG TNF
18 intermediate uveitis 10.1 IFNG TNF
19 orofacial granulomatosis 10.1 IFNG TNF
20 primary systemic mycosis 10.1 IFNG TNF
21 cytomegalovirus retinitis 10.1 IFNG TNF
22 posterior uveitis 10.1 IFNG TNF
23 mycoplasma pneumoniae pneumonia 10.1 IFNG TNF
24 poliomyelitis 10.1 IFNG TNF
25 eales disease 10.1 IFNG TNF
26 hemorrhagic fever 10.1 IFNG TNF
27 lichen disease 10.1 IFNG TNF
28 erythema multiforme 10.1 IFNG TNF
29 pleural tuberculosis 10.1 IFNG TNF
30 spotted fever 10.1 IFNG TNF
31 coccidiosis 10.1 IFNG TNF
32 hematopoietic stem cell transplantation 10.1 IFNG TNF
33 aseptic meningitis 10.1 IFNG TNF
34 plasmodium vivax malaria 10.1 IFNG TNF
35 hypersensitivity reaction type iv disease 10.1 IFNG TNF
36 rasmussen encephalitis 10.1 IFNG TNF
37 leprosy 3 10.1 IFNG TNF
38 q fever 10.1 IFNG TNF
39 acute graft versus host disease 10.1 IFNG TNF
40 hepatitis e 10.1 IFNG TNF
41 lepromatous leprosy 10.1 IFNG TNF
42 spondyloarthropathy 10.1 IFNG TNF
43 congenital cytomegalovirus 10.1 PPARG TNF
44 autoimmune uveitis 10.1 IFNG TNF
45 paracoccidioidomycosis 10.1 IFNG TNF
46 opportunistic mycosis 10.1 IFNG TNF
47 testicular disease 10.1 IFNG TNF
48 mixed connective tissue disease 10.1 IFNG TNF
49 pleurisy 10.1 IFNG TNF
50 echinococcosis 10.1 IFNG TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to Autoimmune Myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

MGI Mouse Phenotypes related to Autoimmune Myocarditis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.88 ICOS IFNG PPARA PPARG SPP1 TNF
2 immune system MP:0005387 9.85 ICOS IFNG PPARA PPARG SPP1 TNF
3 cardiovascular system MP:0005385 9.83 IFNG PPARA PPARG SPP1 TNF
4 integument MP:0010771 9.72 IFNG PPARA PPARG SPP1 TNF
5 liver/biliary system MP:0005370 9.65 IFNG PPARA PPARG SPP1 TNF
6 muscle MP:0005369 9.55 IFNG PPARA PPARG SPP1 TNF
7 neoplasm MP:0002006 9.35 ICOS IFNG PPARG SPP1 TNF
8 no phenotypic analysis MP:0003012 8.92 ICOS IFNG PPARG TNF

Drugs & Therapeutics for Autoimmune Myocarditis

Search Clinical Trials , NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

Anatomical Context for Autoimmune Myocarditis

MalaCards organs/tissues related to Autoimmune Myocarditis:

42
Heart, T Cells, Monocytes, Bone, B Cells, Lung, Thymus

Publications for Autoimmune Myocarditis

Articles related to Autoimmune Myocarditis:

(show top 50) (show all 410)
# Title Authors Year
1
Effects of triptolide and methotrexate nanosuspensions on left ventricular remodeling in autoimmune myocarditis rats. ( 30774338 )
2019
2
Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway. ( 30820154 )
2019
3
Silencing of STAT4 Protects Against Autoimmune Myocarditis by Regulating Th1/Th2 Immune Response via Inactivation of the NF-κB Pathway in Rats. ( 30848408 )
2019
4
Adiponectin deficiency has no effect in murine autoimmune myocarditis. ( 30716658 )
2019
5
Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [<sup>18</sup>F]Fluoromethyl-PBR28 and [<sup>18</sup>F]CB251. ( 29342117 )
2018
6
Urinary candidate biomarkers in an experimental autoimmune myocarditis rat model. ( 29524647 )
2018
7
FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats. ( 29128901 )
2018
8
The dynamic changes in myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 29305900 )
2018
9
Reg3I^ from cardiomyocytes regulated macrophage migration, proliferation and functional skewing in experimental autoimmune myocarditis. ( 29755853 )
2018
10
Autoimmune Myocarditis Caused by Immune Checkpoint Inhibitors Treated With Antithymocyte Globulin. ( 29965858 )
2018
11
Acute autoimmune myocarditis and hepatitis due to ipilimumab monotherapy for malignant melanoma. ( 29444608 )
2018
12
Experimental autoimmune myocarditis in rats and therapeutic histamine H1 - H4 receptor inhibition. ( 30898985 )
2018
13
Fatal autoimmune myocarditis with anti-PD-L1 and tyrosine kinase inhibitor therapy for renal cell cancer. ( 30017380 )
2018
14
Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats. ( 30024944 )
2018
15
TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance. ( 30046376 )
2018
16
Cardiosphere-Derived Cells Attenuate Inflammation, Preserve Systolic Function, and Prevent Adverse Remodeling in Rat Hearts With Experimental Autoimmune Myocarditis. ( 30060693 )
2018
17
Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis. ( 30102319 )
2018
18
The Inflammatory Transcription Factor C/EBPβ Plays a Critical Role in Cardiac Fibroblast Differentiation and a Rat Model of Cardiac Fibrosis Induced by Autoimmune Myocarditis. ( 30305575 )
2018
19
Androgen receptor regulates cardiac fibrosis in mice with experimental autoimmune myocarditis by increasing microRNA-125b expression. ( 30340830 )
2018
20
Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis. ( 30349538 )
2018
21
PPARα suppresses Th17 cell differentiation through IL-6/STAT3 /RORγt pathway in experimental autoimmune myocarditis. ( 30557558 )
2018
22
Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. ( 28903333 )
2017
23
Carvedilol Inhibits Matrix Metalloproteinase-2 Activation in Experimental Autoimmune Myocarditis: Possibilities of Cardioprotective Application. ( 28854816 )
2017
24
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. ( 27922195 )
2017
25
I^1-Adrenergic Receptor Contains Multiple IA<sup>k</sup>and IE<sup>k</sup>Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice. ( 29209317 )
2017
26
Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. ( 28474508 )
2017
27
Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. ( 28246012 )
2017
28
Branched chain I+-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. ( 28597552 )
2017
29
Natural products with anti-inflammatory and immunomodulatory activities against autoimmune myocarditis. ( 28757189 )
2017
30
Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis. ( 28485792 )
2017
31
Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 28178619 )
2017
32
Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-I_B and PI3K/Akt signaling pathway in mice. ( 28485793 )
2017
33
Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation. ( 28772040 )
2017
34
The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis. ( 28618428 )
2017
35
Angiotensin II-C-C chemokine receptor2/5 axis-dependent monocyte/macrophage recruitment contributes to progression of experimental autoimmune myocarditis. ( 29052263 )
2017
36
Regulation of autoimmune myocarditis by host responses to the microbiome. ( 28822770 )
2017
37
A humanized HLA-DR4 mouse model for autoimmune myocarditis. ( 28431892 )
2017
38
Chronic myocarditis with a long clinical course: Report of an autopsy case of probable autoimmune myocarditis. ( 28875521 )
2017
39
Oleuropein prevents the development of experimental autoimmune myocarditis in rats. ( 28525856 )
2017
40
Cholecalciterol cholesterol emulsion attenuates experimental autoimmune myocarditis in mice via inhibition of the pyroptosis signaling pathway. ( 28887037 )
2017
41
FGL2 deteriorates cardiac function in experimental autoimmune myocarditis rats through regulation of PD-1 and inflammatory cytokines. ( 28892130 )
2017
42
The protective effects of taurine on experimental autoimmune myocarditis. ( 28485791 )
2017
43
Novel CMR techniques enable detection of even mild autoimmune myocarditis in a patient with systemic lupus erythematosus. ( 28321496 )
2017
44
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. ( 26772776 )
2016
45
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. ( 27440853 )
2016
46
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. ( 27501378 )
2016
47
11C-methionine PET of myocardial inflammation in a rat model of experimental autoimmune myocarditis. ( 27390159 )
2016
48
Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice. ( 26660726 )
2016
49
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. ( 27615269 )
2016
50
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. ( 27099262 )
2016

Variations for Autoimmune Myocarditis

Expression for Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for Autoimmune Myocarditis

Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.33 ICOS IFNG TNF
2 12.23 ICOS IFNG TNF
3
Show member pathways
12.06 ICOS IFNG TNF
4 11.7 PPARA PPARG TNF
5 11.65 IFNG PPARG TNF
6 11.5 IFNG TNF
7 11.5 PPARA PPARG
8 11.46 PPARA TNF
9 11.44 PPARG TNF
10 11.41 SPP1 TNF
11
Show member pathways
11.4 IFNG TNF
12 11.4 ICOS IFNG TNF
13
Show member pathways
11.38 IFNG TNF
14
Show member pathways
11.31 IFNG PPARG TNF
15 11.29 IFNG TNF
16
Show member pathways
11.27 IFNG TNF
17 11.26 IFNG TNF
18 11.24 IFNG TNF
19 11.23 IFNG TNF
20 11.18 IFNG PPARG TNF
21 11.09 IFNG TNF
22 11.05 PPARA PPARG
23 11 IFNG TNF
24 10.92 IFNG TNF
25 10.9 IFNG SPP1 TNF
26 10.78 PPARG TNF
27 10.45 IFNG SPP1 TNF

GO Terms for Autoimmune Myocarditis

Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.62 PPARA PPARG

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.84 IFNG PPARA PPARG TNF
2 regulation of signaling receptor activity GO:0010469 9.8 IFNG SPP1 TNF
3 positive regulation of transcription, DNA-templated GO:0045893 9.78 PPARA PPARG SPP1 TNF
4 negative regulation of transcription, DNA-templated GO:0045892 9.73 IFNG PPARA PPARG TNF
5 regulation of insulin secretion GO:0050796 9.62 IFNG TNF
6 humoral immune response GO:0006959 9.62 IFNG TNF
7 positive regulation of protein localization to plasma membrane GO:1903078 9.61 IFNG TNF
8 steroid hormone mediated signaling pathway GO:0043401 9.61 PPARA PPARG
9 hormone-mediated signaling pathway GO:0009755 9.6 PPARA PPARG
10 regulation of circadian rhythm GO:0042752 9.59 PPARA PPARG
11 extrinsic apoptotic signaling pathway GO:0097191 9.58 IFNG TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 IFNG TNF
13 intracellular receptor signaling pathway GO:0030522 9.57 PPARA PPARG
14 negative regulation of smooth muscle cell proliferation GO:0048662 9.56 IFNG PPARG
15 positive regulation of protein complex assembly GO:0031334 9.55 IFNG TNF
16 response to organic substance GO:0010033 9.54 PPARG SPP1 TNF
17 response to lipid GO:0033993 9.52 PPARA PPARG
18 positive regulation of osteoclast differentiation GO:0045672 9.51 IFNG TNF
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.49 IFNG TNF
20 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.46 PPARA PPARG
21 negative regulation of cholesterol storage GO:0010887 9.4 PPARA PPARG
22 positive regulation of fatty acid oxidation GO:0046321 9.32 PPARA PPARG
23 negative regulation of sequestering of triglyceride GO:0010891 9.26 PPARA PPARG
24 negative regulation of receptor biosynthetic process GO:0010871 9.16 PPARA PPARG
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.96 IFNG TNF
26 positive regulation of vitamin D biosynthetic process GO:0060557 8.62 IFNG TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.43 PPARA PPARG
2 nuclear receptor transcription coactivator activity GO:0030374 9.4 PPARA PPARG
3 steroid hormone receptor activity GO:0003707 9.37 PPARA PPARG
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.33 PPARA PPARG TNF
5 nuclear receptor activity GO:0004879 9.32 PPARA PPARG
6 RNA polymerase II repressing transcription factor binding GO:0001103 9.26 PPARA PPARG
7 fatty acid binding GO:0005504 8.96 PPARA PPARG
8 cytokine activity GO:0005125 8.8 IFNG SPP1 TNF

Sources for Autoimmune Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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