MCID: ATM022
MIFTS: 35

Autoimmune Myocarditis

Categories: Cardiovascular diseases, Immune diseases, Infectious diseases, Muscle diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Autoimmune Myocarditis

MalaCards integrated aliases for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 12 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0080767

Summaries for Autoimmune Myocarditis

GARD : 20 Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended.

MalaCards based summary : Autoimmune Myocarditis is related to myocarditis and rheumatic fever. An important gene associated with Autoimmune Myocarditis is CD274 (CD274 Molecule), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and RANK Signaling in Osteoclasts. Affiliated tissues include heart, t cells and lung, and related phenotypes are behavior/neurological and hematopoietic system

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by inflammation of the heart muscle.

Related Diseases for Autoimmune Myocarditis

Diseases in the Myocarditis family:

Autoimmune Myocarditis Acute Myocarditis
Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 246)
# Related Disease Score Top Affiliating Genes
1 myocarditis 31.4 TNF IFNG CD274
2 rheumatic fever 29.8 TNF IFNG
3 dilated cardiomyopathy 29.8 TNF SPP1 PPARG IFNG AGTR1
4 proteasome-associated autoinflammatory syndrome 1 29.7 TNF PPARG IFNG
5 cardiac sarcoidosis 29.7 TNF IFNG
6 graft-versus-host disease 29.5 TNF IFNG
7 pericarditis 29.5 TNF IFNG
8 liver cirrhosis 29.0 TNF PPARG IFNG
9 myocardial infarction 28.8 TNF PPARG IFNG AGTR1
10 vascular disease 28.8 TNF SPP1 PPARG IFNG
11 systemic lupus erythematosus 28.7 TNF SPP1 PPARG IFNG CD274
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6
13 autoimmune disease 10.6
14 acute myocarditis 10.5
15 atrial standstill 1 10.4
16 giant cell myocarditis 10.4
17 hemopericardium 10.4
18 pericardial effusion 10.4
19 fibrosis of extraocular muscles, congenital, 1 10.2
20 cytokine deficiency 10.2
21 pertussis 10.2
22 heart disease 10.2
23 congestive heart failure 10.2
24 cardiac conduction defect 10.1
25 hashimoto thyroiditis 10.1
26 rheumatic heart disease 10.1
27 severe combined immunodeficiency 10.1
28 thyroiditis 10.1
29 hyperthyroidism 10.1
30 allergic encephalomyelitis 10.1
31 aortic atherosclerosis 10.0 SPP1 IFNG
32 pleural cancer 10.0 SPP1 CD274
33 epstein-barr virus-associated gastric carcinoma 10.0 TNF CD274
34 staphylococcal toxic shock syndrome 10.0 TNF IFNG
35 spotted fever 10.0 TNF IFNG
36 spotted fever rickettsiosis 10.0 TNF IFNG
37 polyarticular juvenile idiopathic arthritis 10.0 TNF IFNG
38 skeletal tuberculosis 10.0 TNF IFNG
39 chronic beryllium disease 10.0 TNF IFNG
40 skin sarcoidosis 10.0 TNF IFNG
41 opportunistic bacterial infectious disease 10.0 TNF IFNG
42 nocardiosis 10.0 TNF IFNG
43 soft tissue sarcoma 10.0 TNF IFNG
44 gastrointestinal tuberculosis 10.0 TNF IFNG
45 intestinal tuberculosis 10.0 TNF IFNG
46 oral tuberculosis 10.0 TNF IFNG
47 cheilitis 10.0 TNF CD274
48 rheumatic fever-related antigen 10.0
49 chagas disease 10.0
50 graves' disease 10.0

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to Autoimmune Myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

MGI Mouse Phenotypes related to Autoimmune Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.88 AGTR1 CD274 IFNG PPARG SPP1 TNF
2 hematopoietic system MP:0005397 9.85 AGTR1 CD274 IFNG PPARG SPP1 TNF
3 immune system MP:0005387 9.8 AGTR1 CD274 IFNG PPARG SPP1 TNF
4 integument MP:0010771 9.65 CD274 IFNG PPARG SPP1 TNF
5 neoplasm MP:0002006 9.46 IFNG PPARG SPP1 TNF
6 no phenotypic analysis MP:0003012 9.26 CD274 IFNG PPARG TNF
7 skeleton MP:0005390 9.02 CD274 IFNG PPARG SPP1 TNF

Drugs & Therapeutics for Autoimmune Myocarditis

Search Clinical Trials , NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

Anatomical Context for Autoimmune Myocarditis

MalaCards organs/tissues related to Autoimmune Myocarditis:

40
Heart, T Cells, Lung, Bone, Bone Marrow, Lymph Node, Kidney

Publications for Autoimmune Myocarditis

Articles related to Autoimmune Myocarditis:

(show top 50) (show all 747)
# Title Authors PMID Year
1
Immunosuppressive therapy in childhood-onset arrhythmogenic inflammatory cardiomyopathy. 61
33372694 2021
2
Recurrent autoimmune myocarditis in a young woman during the coronavirus disease 2019 pandemic. 61
33225579 2021
3
Angiotensin II receptor 1 controls profibrotic Wnt/β-catenin signalling in experimentalautoimmune myocarditis. 61
33576779 2021
4
Programmed Death-Ligand 2 Deficiency Exacerbates Experimental Autoimmune Myocarditis in Mice. 61
33572655 2021
5
A new player in the game: treatment with antagomiR-21a-5p significantly attenuates histological and echocardiographic effects of experimental autoimmune myocarditis. 61
33483746 2021
6
Immunomodulatory Role of Tenascin-C in Myocarditis and Inflammatory Cardiomyopathy. 61
33692798 2021
7
Transcriptomic Analysis of Inflammatory Cardiomyopathy Identifies Molecular Signatures of Disease and Informs in silico Prediction of a Network-Based Rationale for Therapy. 61
33746983 2021
8
Cardiovascular Toxicity of Immune Checkpoint Inhibitors: Clinical Risk Factors. 61
33415405 2021
9
Current and Future Perspectives of PD-1/PDL-1 Blockade in Cancer Immunotherapy. 61
33681388 2021
10
Circulating Exosomes Control CD4+ T Cell Immunometabolic Functions via the Transfer of miR-142 as a Novel Mediator in Myocarditis. 61
32882180 2020
11
Recurrent Fulminant Myocarditis Accompanied by Lymphoid Follicle Formation in Myocardium. 61
32759592 2020
12
Storm and STEMI: a case report of unexpected cardiac complications of thyrotoxicosis. 61
33442653 2020
13
Folate Receptor β-Targeted PET Imaging of Macrophages in Autoimmune Myocarditis. 61
32284397 2020
14
Pathological manifestation of autoimmune myocarditis is detected prior to glomerulonephritis in a murine model of lupus nephritis. 61
33045900 2020
15
Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation. 61
32681834 2020
16
Non-invasive assessment of early and acute myocarditis in a rat model using cardiac magnetic resonance tissue tracking analysis of myocardial strain. 61
33139995 2020
17
Giant cell myocarditis in an older patient - reassessing the threshold for endomyocardial biopsy. 61
32644298 2020
18
Characterization of dendritic cells in human and experimental myocarditis. 61
32619089 2020
19
Corrigendum to "Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs" (Pharmacol. Res. 146 (2019) 104269). 61
32919214 2020
20
A different type of acute myocarditis: a case report of acute autoimmune myocarditis mediated by anti-PD-1 T lymphocyte receptor (pembrolizumab). 61
33204987 2020
21
Immunohistochemical analysis of periostin in the hearts of Lewis rats with experimental autoimmune myocarditis. 61
32759575 2020
22
Cardiac apoptosis caused by elevated cholesterol level in experimental autoimmune myocarditis. 61
32653410 2020
23
Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis. 61
32577433 2020
24
BML-111 treatment prevents cardiac apoptosis and oxidative stress in a mouse model of autoimmune myocarditis. 61
32543747 2020
25
Intravenous Immunoglobulin Therapy in Myocarditis. 61
33463100 2020
26
Correction: Elevated aldolase 1A, retrogene 1 expression induces cardiac apoptosis in rat experimental autoimmune myocarditis model. 61
32744871 2020
27
Exacerbation of autoimmune myocarditis by an immune checkpoint inhibitor is dependent on its time of administration in mice. 61
32402518 2020
28
Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. 61
32431172 2020
29
T follicular helper cells are elevated in a rat model of autoimmune myocarditis. 61
32416035 2020
30
Therapeutic strategies for virus-negative myocarditis: a comprehensive review. 61
32402564 2020
31
Elevated aldolase 1A, retrogene 1 expression induces cardiac apoptosis in rat experimental autoimmune myocarditis model. 61
31999472 2020
32
Early Detection of Localized Immunity in Experimental Autoimmune Myocarditis Using [99mTc]Fucoidan SPECT. 61
31432389 2020
33
Deficiency of Phospholipase A2 Receptor Exacerbates Autoimmune Myocarditis in Mice. 61
32016628 2020
34
Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation. 61
32160764 2020
35
Synergistic Activation of Toll-Like and NOD Receptors by Complementary Antigens as Facilitators of Autoimmune Disease: Review, Model and Novel Predictions. 61
32629865 2020
36
A Case of Acute Heart Failure Following Immunotherapy for Metastatic Lung Cancer. 61
32542148 2020
37
Interleukin-10 delivered by mesenchymal stem cells attenuates experimental autoimmune myocarditis. 61
32062070 2020
38
[Acute autoimmune myocarditis secondary to Graves' disease: a case report]. 61
31982255 2020
39
An evidence for surface expression of an immunogenic epitope of sarcoplasmic/endoplasmic reticulum calcium-ATPase2a on antigen-presenting cells from naive mice in the mediation of autoimmune myocarditis. 61
31870642 2020
40
Haploinsufficient Rock1+/- and Rock2+/- Mice Are Not Protected from Cardiac Inflammation and Postinflammatory Fibrosis in Experimental Autoimmune Myocarditis. 61
32178482 2020
41
Secreted Phospholipase A2-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation-Fibrosis Link. 61
32046347 2020
42
The role of B regulatory (B10) cells in inflammatory disorders and their potential as therapeutic targets. 61
31881524 2020
43
MicroRNA-223-3p modulates dendritic cell function and ameliorates experimental autoimmune myocarditis by targeting the NLRP3 inflammasome. 61
31743855 2020
44
Bazedoxifene Regulates Th17 Immune Response to Ameliorate Experimental Autoimmune myocarditis via Inhibition of STAT3 Activation. 61
33643041 2020
45
Heart non-specific effector CD4+ T cells protect from postinflammatory fibrosis and cardiac dysfunction in experimental autoimmune myocarditis. 61
31863205 2019
46
Ferumoxytol-enhanced cardiovascular magnetic resonance detection of early stage acute myocarditis. 61
31842900 2019
47
Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis. 61
32128091 2019
48
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy. 61
31727837 2019
49
Blocking LFA-1 Aggravates Cardiac Inflammation in Experimental Autoimmune Myocarditis. 61
31627327 2019
50
STAT4 silencing underlies a novel inhibitory role of microRNA-141-3p in inflammation response of mice with experimental autoimmune myocarditis. 61
31225989 2019

Variations for Autoimmune Myocarditis

Expression for Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for Autoimmune Myocarditis

Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 TNF SPP1 PPARG IFNG
2
Show member pathways
12.33 TNF PPARG IFNG
3
Show member pathways
12.23 TNF IFNG CD274
4
Show member pathways
12.2 TNF IFNG AGTR1
5 12.17 TNF IFNG CD274
6
Show member pathways
11.4 TNF IFNG
7 11.39 TNF SPP1
8
Show member pathways
11.37 TNF IFNG
9 11.27 TNF IFNG
10
Show member pathways
11.27 TNF IFNG
11 11.25 TNF IFNG
12 11.22 TNF IFNG
13 11.21 TNF IFNG
14
Show member pathways
11.21 TNF PPARG IFNG
15 11.02 TNF IFNG
16
Show member pathways
10.99 TNF IFNG
17 10.9 TNF SPP1 IFNG
18 10.87 TNF IFNG
19 10.78 TNF IFNG
20 10.6 TNF PPARG
21 10.45 TNF SPP1 IFNG

GO Terms for Autoimmune Myocarditis

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.81 TNF SPP1 AGTR1
2 positive regulation of protein localization to plasma membrane GO:1903078 9.63 TNF IFNG
3 humoral immune response GO:0006959 9.62 TNF IFNG
4 positive regulation of interleukin-1 beta production GO:0032731 9.62 TNF IFNG
5 positive regulation of protein complex assembly GO:0031334 9.61 TNF IFNG
6 positive regulation of cytokine production GO:0001819 9.61 TNF IFNG
7 negative regulation of osteoblast differentiation GO:0045668 9.6 TNF PPARG
8 negative regulation of signaling receptor activity GO:2000272 9.59 TNF PPARG
9 positive regulation of phagocytosis GO:0050766 9.58 TNF IFNG
10 negative regulation of blood vessel endothelial cell migration GO:0043537 9.58 TNF PPARG
11 extrinsic apoptotic signaling pathway GO:0097191 9.57 TNF IFNG
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 TNF IFNG
13 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.55 TNF PPARG
14 positive regulation of chemokine production GO:0032722 9.54 TNF IFNG
15 negative regulation of smooth muscle cell proliferation GO:0048662 9.52 PPARG IFNG
16 microglial cell activation GO:0001774 9.51 TNF IFNG
17 positive regulation of inflammatory response GO:0050729 9.5 TNF IFNG AGTR1
18 positive regulation of osteoclast differentiation GO:0045672 9.49 TNF IFNG
19 regulation of fat cell differentiation GO:0045598 9.48 TNF PPARG
20 positive regulation of amyloid-beta formation GO:1902004 9.46 TNF IFNG
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.43 TNF IFNG
22 response to organic substance GO:0010033 9.43 TNF SPP1 PPARG
23 astrocyte activation GO:0048143 9.4 TNF IFNG
24 negative regulation of amyloid-beta clearance GO:1900222 9.37 TNF IFNG
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 TNF IFNG
26 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
27 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 TNF SPP1 IFNG

Sources for Autoimmune Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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