MCID: ATM022
MIFTS: 41

Autoimmune Myocarditis

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Autoimmune Myocarditis

MalaCards integrated aliases for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 53

Classifications:



Summaries for Autoimmune Myocarditis

NIH Rare Diseases : 53 Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended.

MalaCards based summary : Autoimmune Myocarditis is related to periodontitis and celiac disease 1. An important gene associated with Autoimmune Myocarditis is SPP1 (Secreted Phosphoprotein 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. Affiliated tissues include heart, t cells and monocytes, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Autoimmune Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis Post-Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 periodontitis 29.3 IFNG IL1B TNF
2 celiac disease 1 28.5 IFNG IL2 TNF
3 autoimmune disease 27.8 IFNG IL1B IL2 TNF
4 systemic lupus erythematosus 27.7 IFNG IL2 SPP1 TNF
5 myocarditis 11.0
6 campylobacteriosis 10.4 IFNG IL1B
7 root resorption 10.4 IL1B SPP1
8 fascioliasis 10.4 IFNG IL1B
9 eumycotic mycetoma 10.4 IFNG IL1B
10 leukomalacia 10.4 SPP1 TNF
11 extrapulmonary tuberculosis 10.3 IFNG IL1B
12 trichosporonosis 10.3 IFNG TNF
13 chronic beryllium disease 10.3 IFNG TNF
14 meconium aspiration syndrome 10.3 IFNG TNF
15 soft tissue sarcoma 10.3 IFNG TNF
16 cytomegalovirus retinitis 10.3 IFNG TNF
17 tuberculous peritonitis 10.3 IFNG TNF
18 primary systemic mycosis 10.3 IFNG TNF
19 poliomyelitis 10.3 IFNG TNF
20 orofacial granulomatosis 10.3 IFNG TNF
21 hemorrhagic fever 10.2 IFNG TNF
22 pleural tuberculosis 10.2 IFNG TNF
23 spotted fever 10.2 IFNG TNF
24 lichen disease 10.2 IFNG TNF
25 cytomegalovirus infection 10.2 IFNG TNF
26 plasmodium vivax malaria 10.2 IFNG TNF
27 systemic onset juvenile idiopathic arthritis 10.2 IL1B TNF
28 hepatitis e 10.2 IFNG TNF
29 kashin-beck disease 10.2 IL1B TNF
30 vulvar vestibulitis syndrome 10.2 IL1B TNF
31 burns 10.2 IL1B TNF
32 laryngitis 10.2 IL1B TNF
33 cerebral artery occlusion 10.2 IL1B TNF
34 haemophilus influenzae 10.2 IL1B TNF
35 retinitis pigmentosa 60 10.2 IL1B TNF
36 rasmussen encephalitis 10.2 IFNG TNF
37 irritant dermatitis 10.2 IL1B TNF
38 acute vascular insufficiency of intestine 10.2 IL1B TNF
39 actinic prurigo 10.2 IL1B TNF
40 poems syndrome 10.2 IL1B TNF
41 salmonellosis 10.2 IFNG IL1B
42 central nervous system vasculitis 10.2 IL1B TNF
43 osteosclerotic myeloma 10.2 IL1B TNF
44 stachybotrys chartarum 10.2 IL1B TNF
45 dental pulp disease 10.2 IL1B TNF
46 jejunoileitis 10.2 IL1B TNF
47 blau syndrome 10.2 IL1B TNF
48 endometritis 10.2 IL1B TNF
49 opportunistic mycosis 10.2 IFNG TNF
50 scrub typhus 10.2 IL1B TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to Autoimmune Myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

MGI Mouse Phenotypes related to Autoimmune Myocarditis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.99 IL1B SPP1 IL2 TNF IFNG PPARG
2 growth/size/body region MP:0005378 9.95 TNF IL1B SPP1 IL2 IFNG PPARG
3 hematopoietic system MP:0005397 9.93 TNF IL1B SPP1 IL2 IFNG PPARG
4 homeostasis/metabolism MP:0005376 9.91 TNF PPARG IL1B SPP1 IL2 IFNG
5 immune system MP:0005387 9.88 TNF IL1B SPP1 IL2 IFNG PPARG
6 craniofacial MP:0005382 9.8 TNF IFNG IL1B SPP1
7 integument MP:0010771 9.77 TNF IL1B SPP1 IFNG PPARG
8 mortality/aging MP:0010768 9.73 TNF IFNG PPARG IL1B SPP1 IL2
9 liver/biliary system MP:0005370 9.72 TNF SPP1 IL2 IFNG PPARG
10 neoplasm MP:0002006 9.63 IL1B SPP1 IL2 TNF IFNG PPARG
11 reproductive system MP:0005389 9.35 TNF SPP1 IL2 IFNG PPARG
12 skeleton MP:0005390 9.02 TNF PPARG IL1B SPP1 IFNG

Drugs & Therapeutics for Autoimmune Myocarditis

Search Clinical Trials , NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

Anatomical Context for Autoimmune Myocarditis

MalaCards organs/tissues related to Autoimmune Myocarditis:

41
Heart, T Cells, Monocytes, B Cells, Bone, Lung, Thymus

Publications for Autoimmune Myocarditis

Articles related to Autoimmune Myocarditis:

(show top 50) (show all 390)
# Title Authors Year
1
Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [<sup>18</sup>F]Fluoromethyl-PBR28 and [<sup>18</sup>F]CB251. ( 29342117 )
2018
2
Urinary candidate biomarkers in an experimental autoimmune myocarditis rat model. ( 29524647 )
2018
3
FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats. ( 29128901 )
2018
4
The dynamic changes in myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 29305900 )
2018
5
Reg3I^ from cardiomyocytes regulated macrophage migration, proliferation and functional skewing in experimental autoimmune myocarditis. ( 29755853 )
2018
6
Autoimmune Myocarditis Caused by Immune Checkpoint Inhibitors Treated With Antithymocyte Globulin. ( 29965858 )
2018
7
Acute autoimmune myocarditis and hepatitis due to ipilimumab monotherapy for malignant melanoma. ( 29444608 )
2018
8
Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. ( 28903333 )
2017
9
Carvedilol Inhibits Matrix Metalloproteinase-2 Activation in Experimental Autoimmune Myocarditis: Possibilities of Cardioprotective Application. ( 28854816 )
2017
10
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. ( 27922195 )
2017
11
I^1-Adrenergic Receptor Contains Multiple IA<sup>k</sup>and IE<sup>k</sup>Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice. ( 29209317 )
2017
12
Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. ( 28474508 )
2017
13
Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. ( 28246012 )
2017
14
Branched chain I+-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. ( 28597552 )
2017
15
Natural products with anti-inflammatory and immunomodulatory activities against autoimmune myocarditis. ( 28757189 )
2017
16
Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis. ( 28485792 )
2017
17
Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 28178619 )
2017
18
Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-I_B and PI3K/Akt signaling pathway in mice. ( 28485793 )
2017
19
Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation. ( 28772040 )
2017
20
The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis. ( 28618428 )
2017
21
Angiotensin II-C-C chemokine receptor2/5 axis-dependent monocyte/macrophage recruitment contributes to progression of experimental autoimmune myocarditis. ( 29052263 )
2017
22
Regulation of autoimmune myocarditis by host responses to the microbiome. ( 28822770 )
2017
23
A humanized HLA-DR4 mouse model for autoimmune myocarditis. ( 28431892 )
2017
24
Chronic myocarditis with a long clinical course: Report of an autopsy case of probable autoimmune myocarditis. ( 28875521 )
2017
25
Oleuropein prevents the development of experimental autoimmune myocarditis in rats. ( 28525856 )
2017
26
Cholecalciterol cholesterol emulsion attenuates experimental autoimmune myocarditis in mice via inhibition of the pyroptosis signaling pathway. ( 28887037 )
2017
27
FGL2 deteriorates cardiac function in experimental autoimmune myocarditis rats through regulation of PD-1 and inflammatory cytokines. ( 28892130 )
2017
28
The protective effects of taurine on experimental autoimmune myocarditis. ( 28485791 )
2017
29
Novel CMR techniques enable detection of even mild autoimmune myocarditis in a patient with systemic lupus erythematosus. ( 28321496 )
2017
30
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation. ( 26772776 )
2016
31
Suspected autoimmune myocarditis and cardiac conduction abnormalities with nivolumab therapy for non-small cell lung cancer. ( 27440853 )
2016
32
Targeted Therapy for Acute Autoimmune Myocarditis with Nano-Sized Liposomal FK506 in Rats. ( 27501378 )
2016
33
11C-methionine PET of myocardial inflammation in a rat model of experimental autoimmune myocarditis. ( 27390159 )
2016
34
Pathogenic IL-23 signaling is required to initiate GM-CSF-driven autoimmune myocarditis in mice. ( 26660726 )
2016
35
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. ( 27615269 )
2016
36
Transforming growth factor-I^-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. ( 27099262 )
2016
37
Noninvasive Contrast-Enhanced Ultrasound Molecular Imaging Detects Myocardial Inflammatory Response in Autoimmune Myocarditis. ( 27502060 )
2016
38
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model. ( 27044832 )
2016
39
Drugs Targeting the Canonical NF-I_B Pathway to Treat Viral and Autoimmune Myocarditis. ( 26696258 )
2016
40
Effects of 1, 25-Dihydroxyvitamin D3 on Experimental Autoimmune Myocarditis in Mice. ( 27184135 )
2016
41
Recent advances in the management of autoimmune myocarditis: insights from animal studies. ( 26696255 )
2016
42
Effect and Mechanism of QiShenYiQi Pill on Experimental Autoimmune Myocarditis Rats. ( 26946470 )
2016
43
Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. ( 26658748 )
2016
44
Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation. ( 27342875 )
2016
45
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. ( 26621778 )
2016
46
Cacao polyphenols ameliorate autoimmune myocarditis in mice. ( 26657007 )
2016
47
Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) as a Biomarker in the Mouse Model of Experimental Autoimmune Myocarditis (EAM). ( 27501319 )
2016
48
HMGB1 Facilitated Macrophage Reprogramming towards a Proinflammatory M1-like Phenotype in Experimental Autoimmune Myocarditis Development. ( 26899795 )
2016
49
Inhibition of microRNA-155 ameliorates experimental autoimmune myocarditis by modulating Th17/Treg immune response. ( 27052830 )
2016
50
Corrigendum: Cacao polyphenols ameliorate autoimmune myocarditis in mice. ( 27818491 )
2016

Variations for Autoimmune Myocarditis

Expression for Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for Autoimmune Myocarditis

Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 IFNG IL1B IL2 TNF
2
Show member pathways
12.8 IFNG IL1B IL2 SPP1 TNF
3
Show member pathways
12.7 IFNG IL1B IL2 TNF
4
Show member pathways
12.64 IFNG IL1B IL2 TNF
5
Show member pathways
12.56 IFNG IL1B IL2 SPP1 TNF
6
Show member pathways
12.52 IL1B IL2 TNF
7
Show member pathways
12.51 IFNG IL1B IL2 TNF
8
Show member pathways
12.49 IFNG IL1B TNF
9
Show member pathways
12.46 IFNG IL1B IL2 TNF
10 12.44 IFNG IL1B IL2 TNF
11
Show member pathways
12.36 IFNG IL2 TNF
12
Show member pathways
12.31 IFNG IL1B IL2 TNF
13
Show member pathways
12.29 IFNG IL1B IL2 TNF
14
Show member pathways
12.2 IFNG IL1B TNF
15
Show member pathways
12.17 IFNG IL1B IL2 TNF
16
Show member pathways
12.14 IFNG IL1B TNF
17
Show member pathways
12.13 IFNG IL1B TNF
18 12.11 IFNG IL1B TNF
19
Show member pathways
12.09 IL1B IL2 TNF
20
Show member pathways
12.09 IFNG IL1B TNF
21
Show member pathways
12.09 IFNG IL1B IL2 TNF
22
Show member pathways
12.05 IFNG IL1B TNF
23 11.97 IFNG IL1B TNF
24
Show member pathways
11.91 IFNG IL1B IL2
25 11.89 IFNG IL2 TNF
26
Show member pathways
11.87 IFNG IL1B IL2
27 11.87 IFNG IL1B PPARG TNF
28 11.81 IFNG IL1B IL2 TNF
29 11.8 IFNG IL1B TNF
30 11.76 IFNG IL1B TNF
31 11.61 IFNG IL1B IL2 TNF
32 11.59 IL1B SPP1 TNF
33
Show member pathways
11.57 IFNG IL2 TNF
34 11.55 IFNG IL2
35 11.55 PPARG TNF
36
Show member pathways
11.55 IFNG IL2 PPARG TNF
37 11.54 IFNG SPP1 TNF
38 11.49 IFNG IL1B IL2 TNF
39 11.47 IFNG IL2 TNF
40 11.46 IL1B TNF
41 11.43 IFNG IL1B TNF
42
Show member pathways
11.42 IFNG TNF
43 11.42 IFNG IL1B TNF
44 11.41 IL1B TNF
45 11.38 IFNG IL2
46
Show member pathways
11.36 IFNG IL1B IL2 TNF
47
Show member pathways
11.35 IL1B TNF
48 11.28 IFNG IL1B
49 11.25 IL1B TNF
50 11.24 IFNG IL1B TNF

GO Terms for Autoimmune Myocarditis

Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 IFNG IL1B IL2 SPP1 TNF
2 extracellular space GO:0005615 9.02 IFNG IL1B IL2 SPP1 TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.96 IL1B IL2 PPARG TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.87 IL1B PPARG SPP1 TNF
3 inflammatory response GO:0006954 9.86 IL1B SPP1 TNF
4 positive regulation of gene expression GO:0010628 9.85 IFNG IL1B TNF
5 immune response GO:0006955 9.85 IFNG IL1B IL2 TNF
6 cytokine-mediated signaling pathway GO:0019221 9.83 IL1B IL2 TNF
7 MAPK cascade GO:0000165 9.81 IL1B IL2 TNF
8 positive regulation of DNA binding transcription factor activity GO:0051091 9.71 IL1B PPARG TNF
9 response to organic substance GO:0010033 9.69 PPARG SPP1 TNF
10 positive regulation of T cell proliferation GO:0042102 9.68 IL1B IL2
11 humoral immune response GO:0006959 9.68 IFNG TNF
12 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B TNF
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.67 IL1B TNF
14 protein kinase B signaling GO:0043491 9.67 IL1B TNF
15 extrinsic apoptotic signaling pathway GO:0097191 9.66 IFNG TNF
16 embryo implantation GO:0007566 9.65 IL1B SPP1
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.65 IL1B TNF
18 positive regulation of phagocytosis GO:0050766 9.64 IL1B TNF
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
20 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.63 IL1B IL2
21 regulation of insulin secretion GO:0050796 9.63 IFNG IL1B TNF
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.62 IL1B TNF
23 negative regulation of smooth muscle cell proliferation GO:0048662 9.62 IFNG PPARG
24 protein import into nucleus, translocation GO:0000060 9.61 IFNG TNF
25 positive regulation of interleukin-8 production GO:0032757 9.61 IL1B TNF
26 positive regulation of protein complex assembly GO:0031334 9.6 IFNG TNF
27 positive regulation of osteoclast differentiation GO:0045672 9.59 IFNG TNF
28 negative regulation of lipid catabolic process GO:0050995 9.58 IL1B TNF
29 regulation of regulatory T cell differentiation GO:0045589 9.58 IFNG IL2
30 positive regulation of interferon-gamma production GO:0032729 9.58 IL1B IL2 TNF
31 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL1B TNF
32 positive regulation of protein phosphorylation GO:0001934 9.56 IFNG IL1B IL2 TNF
33 regulation of signaling receptor activity GO:0010469 9.55 IFNG IL1B IL2 SPP1 TNF
34 positive regulation of chemokine biosynthetic process GO:0045080 9.52 IL1B TNF
35 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 IFNG IL1B TNF
36 regulation of establishment of endothelial barrier GO:1903140 9.49 IL1B TNF
37 positive regulation of fever generation GO:0031622 9.48 IL1B TNF
38 sequestering of triglyceride GO:0030730 9.43 IL1B TNF
39 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 IFNG TNF
40 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.13 IFNG IL1B TNF
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL1B IL2 SPP1 TNF

Sources for Autoimmune Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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