MCID: ATM022
MIFTS: 41

Autoimmune Myocarditis

Categories: Cardiovascular diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Autoimmune Myocarditis

MalaCards integrated aliases for Autoimmune Myocarditis:

Name: Autoimmune Myocarditis 54

Classifications:



Summaries for Autoimmune Myocarditis

NIH Rare Diseases : 54 Autoimmune myocarditis is an autoimmune disease that affects the heart. The condition is characterized by inflammation of the heart muscle (myocardium). Some people with autoimmune myocarditis have no noticeable symptoms of the condition. When present, signs and symptoms may include chest pain, abnormal heartbeat, shortness of breath, fatigue, signs of infection (i.e. fever, headache, sore throat, diarrhea), and leg swelling. The exact underlying cause of the condition is currently unknown; however, autoimmune conditions, in general, occur when the immune system mistakenly attacks healthy tissue. Treatment is based on the signs and symptoms present in each person. In some cases, medications that suppress the immune system may be recommended.

MalaCards based summary : Autoimmune Myocarditis is related to rheumatic heart disease and infective endocarditis. An important gene associated with Autoimmune Myocarditis is IFNG (Interferon Gamma), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Th17 cell differentiation. Affiliated tissues include heart, t cells and bone, and related phenotypes are cellular and hematopoietic system

Related Diseases for Autoimmune Myocarditis

Diseases in the Myocarditis family:

Acute Myocarditis Autoimmune Myocarditis
Infectious Myocarditis

Diseases related to Autoimmune Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 rheumatic heart disease 29.9 IL6 TNF
2 infective endocarditis 29.6 IL6 TNF
3 endocarditis 29.6 IL6 TNF
4 autoimmune disease 29.5 IFNG IL6 TNF
5 systemic lupus erythematosus 28.7 IFNG IL6 SPP1 TNF
6 myocarditis 11.1
7 rere-related disorders 10.3
8 dilated cardiomyopathy 10.3
9 aspergillosis 10.2 IFNG TNF
10 cutaneous leishmaniasis 10.2 IFNG TNF
11 pulmonary sarcoidosis 10.2 IFNG TNF
12 autoimmune uveitis 10.2 IFNG TNF
13 pleurisy 10.2 IFNG TNF
14 mumps 10.2 IFNG TNF
15 hepatitis a 10.2 IFNG TNF
16 lymphadenitis 10.2 IFNG TNF
17 neuritis 10.2 IFNG TNF
18 opportunistic mycosis 10.2 IFNG TNF
19 testicular disease 10.2 IFNG TNF
20 severe acute respiratory syndrome 10.2 IFNG TNF
21 allergic contact dermatitis 10.2 IFNG TNF
22 hepatitis e 10.2 IFNG TNF
23 reactive arthritis 10.2 IFNG TNF
24 smallpox 10.2 IFNG TNF
25 visceral leishmaniasis 10.2 IFNG TNF
26 keratoconjunctivitis 10.2 IFNG TNF
27 alopecia areata 10.2 IFNG TNF
28 acute graft versus host disease 10.2 IFNG TNF
29 staphylococcal toxic shock syndrome 10.2 IFNG TNF
30 trichosporonosis 10.1 IFNG TNF
31 chronic beryllium disease 10.1 IFNG TNF
32 scleritis 10.1 IFNG TNF
33 miliary tuberculosis 10.1 IFNG TNF
34 chronic graft versus host disease 10.1 IFNG TNF
35 clonorchiasis 10.1 IFNG TNF
36 microscopic colitis 10.1 IFNG TNF
37 crohn's colitis 10.1 IFNG TNF
38 carotid stenosis 10.1 SPP1 TNF
39 pleural disease 10.1 SPP1 TNF
40 soft tissue sarcoma 10.1 IFNG TNF
41 tuberculous peritonitis 10.1 IFNG TNF
42 congenital cytomegalovirus 10.1 PPARG TNF
43 orofacial granulomatosis 10.1 IFNG TNF
44 primary systemic mycosis 10.1 IFNG TNF
45 cytomegalovirus retinitis 10.1 IFNG TNF
46 systemic onset juvenile idiopathic arthritis 10.1 MIF TNF
47 poliomyelitis 10.1 IFNG TNF
48 lichen disease 10.1 IFNG TNF
49 tropical spastic paraparesis 10.1 IFNG IL6
50 erythema multiforme 10.1 IFNG TNF

Graphical network of the top 20 diseases related to Autoimmune Myocarditis:



Diseases related to Autoimmune Myocarditis

Symptoms & Phenotypes for Autoimmune Myocarditis

MGI Mouse Phenotypes related to Autoimmune Myocarditis:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.99 IFNG IL6 MIF PPARG SPP1 TNF
2 hematopoietic system MP:0005397 9.97 IFNG IL6 MIF PPARG SPP1 TNF
3 homeostasis/metabolism MP:0005376 9.95 IFNG IL6 MIF PPARG SPP1 TNF
4 immune system MP:0005387 9.93 IFNG IL6 MIF PPARG SPP1 TNF
5 cardiovascular system MP:0005385 9.92 IFNG IL6 PPARG SPP1 TNF
6 integument MP:0010771 9.83 IFNG IL6 PPARG SPP1 TNF
7 liver/biliary system MP:0005370 9.8 IFNG IL6 PPARG SPP1 TNF
8 neoplasm MP:0002006 9.8 IFNG IL6 MIF PPARG SPP1 TNF
9 muscle MP:0005369 9.77 IFNG IL6 PPARG SPP1 TNF
10 nervous system MP:0003631 9.73 IFNG IL6 MIF PPARG SPP1 TNF
11 renal/urinary system MP:0005367 9.46 IFNG IL6 PPARG SPP1
12 reproductive system MP:0005389 9.35 IFNG IL6 PPARG SPP1 TNF
13 skeleton MP:0005390 9.02 IFNG IL6 PPARG SPP1 TNF

Drugs & Therapeutics for Autoimmune Myocarditis

Search Clinical Trials , NIH Clinical Center for Autoimmune Myocarditis

Genetic Tests for Autoimmune Myocarditis

Anatomical Context for Autoimmune Myocarditis

MalaCards organs/tissues related to Autoimmune Myocarditis:

42
Heart, T Cells, Bone, Lung, Monocytes, B Cells, Thyroid

Publications for Autoimmune Myocarditis

Articles related to Autoimmune Myocarditis:

(show top 50) (show all 411)
# Title Authors Year
1
Cardiosphere-Derived Cells Attenuate Inflammation, Preserve Systolic Function, and Prevent Adverse Remodeling in Rat Hearts With Experimental Autoimmune Myocarditis. ( 30060693 )
2019
2
Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis. ( 30102319 )
2019
3
Adiponectin deficiency has no effect in murine autoimmune myocarditis. ( 30716658 )
2019
4
Effects of triptolide and methotrexate nanosuspensions on left ventricular remodeling in autoimmune myocarditis rats. ( 30774338 )
2019
5
Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway. ( 30820154 )
2019
6
Silencing of STAT4 Protects Against Autoimmune Myocarditis by Regulating Th1/Th2 Immune Response via Inactivation of the NF-κB Pathway in Rats. ( 30848408 )
2019
7
Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs. ( 31078745 )
2019
8
Carvedilol Inhibits Matrix Metalloproteinase-2 Activation in Experimental Autoimmune Myocarditis: Possibilities of Cardioprotective Application. ( 28854816 )
2018
9
Fibrinogen-like protein-2 causes deterioration in cardiac function in experimental autoimmune myocarditis rats through regulation of programmed death-1 and inflammatory cytokines. ( 28892130 )
2018
10
FGL2 knockdown improves heart function through regulation of TLR9 signaling in the experimental autoimmune myocarditis rats. ( 29128901 )
2018
11
The dynamic changes in myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 29305900 )
2018
12
Assessment of TSPO in a Rat Experimental Autoimmune Myocarditis Model: A Comparison Study between [18F]Fluoromethyl-PBR28 and [18F]CB251. ( 29342117 )
2018
13
Acute autoimmune myocarditis and hepatitis due to ipilimumab monotherapy for malignant melanoma. ( 29444608 )
2018
14
Urinary candidate biomarkers in an experimental autoimmune myocarditis rat model. ( 29524647 )
2018
15
Reg3β from cardiomyocytes regulated macrophage migration, proliferation and functional skewing in experimental autoimmune myocarditis. ( 29755853 )
2018
16
Autoimmune Myocarditis Caused by Immune Checkpoint Inhibitors Treated With Antithymocyte Globulin. ( 29965858 )
2018
17
Fatal autoimmune myocarditis with anti-PD-L1 and tyrosine kinase inhibitor therapy for renal cell cancer. ( 30017380 )
2018
18
Small molecule disruption of G protein βγ subunit signaling reprograms human macrophage phenotype and prevents autoimmune myocarditis in rats. ( 30024944 )
2018
19
TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance. ( 30046376 )
2018
20
The Inflammatory Transcription Factor C/EBPβ Plays a Critical Role in Cardiac Fibroblast Differentiation and a Rat Model of Cardiac Fibrosis Induced by Autoimmune Myocarditis. ( 30305575 )
2018
21
Androgen receptor regulates cardiac fibrosis in mice with experimental autoimmune myocarditis by increasing microRNA-125b expression. ( 30340830 )
2018
22
Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis. ( 30349538 )
2018
23
PPARα suppresses Th17 cell differentiation through IL-6/STAT3 /RORγt pathway in experimental autoimmune myocarditis. ( 30557558 )
2018
24
Experimental autoimmune myocarditis in rats and therapeutic histamine H1 - H4 receptor inhibition. ( 30898985 )
2018
25
The neuropeptide cortistatin attenuates experimental autoimmune myocarditis via inhibition of cardiomyogenic T cell-driven inflammatory responses. ( 27922195 )
2017
26
Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats. ( 28178619 )
2017
27
Targeting androgen receptor with ASC-J9 attenuates cardiac injury and dysfunction in experimental autoimmune myocarditis by reducing M1-like macrophage. ( 28246012 )
2017
28
Novel CMR techniques enable detection of even mild autoimmune myocarditis in a patient with systemic lupus erythematosus. ( 28321496 )
2017
29
A humanized HLA-DR4 mouse model for autoimmune myocarditis. ( 28431892 )
2017
30
Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. ( 28474508 )
2017
31
The protective effects of taurine on experimental autoimmune myocarditis. ( 28485791 )
2017
32
Increased expression of CXCR5 and CXCL13 in mice with experimental autoimmune myocarditis. ( 28485792 )
2017
33
Lipoxin A4 mitigates experimental autoimmune myocarditis by regulating inflammatory response, NF-κB and PI3K/Akt signaling pathway in mice. ( 28485793 )
2017
34
Oleuropein prevents the development of experimental autoimmune myocarditis in rats. ( 28525856 )
2017
35
Branched chain α-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. ( 28597552 )
2017
36
The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis. ( 28618428 )
2017
37
Natural products with anti-inflammatory and immunomodulatory activities against autoimmune myocarditis. ( 28757189 )
2017
38
Autoimmune myocarditis in systemic sclerosis: an unusual form of scleroderma heart disease presentation. ( 28772040 )
2017
39
Regulation of autoimmune myocarditis by host responses to the microbiome. ( 28822770 )
2017
40
Chronic myocarditis with a long clinical course: Report of an autopsy case of probable autoimmune myocarditis. ( 28875521 )
2017
41
Cholecalciterol cholesterol emulsion attenuates experimental autoimmune myocarditis in mice via inhibition of the pyroptosis signaling pathway. ( 28887037 )
2017
42
Effect of PKC inhibitor on experimental autoimmune myocarditis in Lewis rats. ( 28903333 )
2017
43
Angiotensin II-C-C chemokine receptor2/5 axis-dependent monocyte/macrophage recruitment contributes to progression of experimental autoimmune myocarditis. ( 29052263 )
2017
44
β1-Adrenergic Receptor Contains Multiple IAk and IEk Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A/J Mice. ( 29209317 )
2017
45
Transforming growth factor-β-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis. ( 27099262 )
2017
46
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats. ( 27615269 )
2017
47
Localization of CD8 T cell epitope within cardiac myosin heavy chain-α334-352 that induces autoimmune myocarditis in A/J mice. ( 26422020 )
2016
48
Anti-inflammatory role of obestatin in autoimmune myocarditis. ( 26426263 )
2016
49
Suppression of murine autoimmune myocarditis achieved with direct renin inhibition. ( 26475067 )
2016
50
Absence of nonhematopoietic MHC class II expression protects mice from experimental autoimmune myocarditis. ( 26621778 )
2016

Variations for Autoimmune Myocarditis

Expression for Autoimmune Myocarditis

Search GEO for disease gene expression data for Autoimmune Myocarditis.

Pathways for Autoimmune Myocarditis

Pathways related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 IFNG IL6 SPP1 TNF
2
Show member pathways
12.38 IFNG IL6 TNF
3
Show member pathways
12.37 IFNG IL6 TNF
4
Show member pathways
12.36 IFNG IL6 TNF
5
Show member pathways
12.15 IFNG IL6 TNF
6
Show member pathways
12.15 IFNG IL6 TNF
7
Show member pathways
12.07 IFNG IL6 MIF TNF
8
Show member pathways
12.05 IFNG IL6 TNF
9 12.05 IFNG IL6 TNF
10
Show member pathways
12.01 IFNG IL6 TNF
11 12 IFNG IL6 TNF
12
Show member pathways
11.9 IFNG IL6 TNF
13 11.88 IFNG PPARG TNF
14
Show member pathways
11.87 IFNG IL6 TNF
15 11.82 IFNG IL6 TNF
16 11.74 IL6 MIF PPARG TNF
17 11.73 IFNG IL6 TNF
18 11.7 IFNG IL6 TNF
19 11.64 IFNG IL6 MIF TNF
20
Show member pathways
11.61 IFNG PPARG TNF
21 11.59 IFNG IL6 TNF
22 11.51 IL6 SPP1 TNF
23
Show member pathways
11.48 IFNG TNF
24 11.46 IFNG SPP1 TNF
25 11.43 IFNG IL6
26 11.43 IL6 TNF
27 11.39 IFNG IL6 TNF
28
Show member pathways
11.38 IFNG TNF
29 11.37 IL6 TNF
30 11.36 IL6 TNF
31 11.36 IFNG IL6 TNF
32 11.35 IFNG TNF
33 11.35 IFNG TNF
34 11.31 IFNG IL6 PPARG TNF
35 11.2 IL6 TNF
36 11.2 IFNG IL6 TNF
37 11.14 IL6 TNF
38 11.11 IFNG IL6 TNF
39
Show member pathways
11.06 IFNG IL6 MIF TNF
40 11.04 IFNG IL6 TNF
41 10.91 IL6 TNF
42 10.89 IL6 PPARG TNF
43 10.58 IFNG IL6 SPP1 TNF

GO Terms for Autoimmune Myocarditis

Cellular components related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 IFNG IL6 MIF SPP1 TNF
2 extracellular space GO:0005615 9.02 IFNG IL6 MIF SPP1 TNF

Biological processes related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.83 IFNG IL6 TNF
2 positive regulation of transcription, DNA-templated GO:0045893 9.81 IL6 PPARG SPP1 TNF
3 positive regulation of apoptotic process GO:0043065 9.8 IL6 PPARG TNF
4 negative regulation of gene expression GO:0010629 9.78 IFNG MIF TNF
5 positive regulation of protein phosphorylation GO:0001934 9.73 IFNG MIF TNF
6 inflammatory response GO:0006954 9.67 IL6 MIF SPP1 TNF
7 positive regulation of MAP kinase activity GO:0043406 9.66 MIF TNF
8 positive regulation of interleukin-6 production GO:0032755 9.65 IL6 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.65 IL6 TNF
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.65 IL6 PPARG TNF
11 positive regulation of protein localization to plasma membrane GO:1903078 9.64 IFNG TNF
12 negative regulation of fat cell differentiation GO:0045599 9.64 IL6 TNF
13 interleukin-12-mediated signaling pathway GO:0035722 9.63 IFNG MIF
14 response to organic substance GO:0010033 9.63 PPARG SPP1 TNF
15 extrinsic apoptotic signaling pathway GO:0097191 9.62 IFNG TNF
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 IFNG TNF
17 negative regulation of smooth muscle cell proliferation GO:0048662 9.61 IFNG PPARG
18 positive regulation of cytokine secretion GO:0050715 9.6 MIF TNF
19 negative regulation of neurogenesis GO:0050768 9.59 IL6 TNF
20 positive regulation of protein complex assembly GO:0031334 9.58 IFNG TNF
21 positive regulation of osteoclast differentiation GO:0045672 9.58 IFNG TNF
22 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.58 IL6 MIF TNF
23 positive regulation of chemokine production GO:0032722 9.57 IL6 TNF
24 negative regulation of collagen biosynthetic process GO:0032966 9.55 IL6 PPARG
25 positive regulation of glial cell proliferation GO:0060252 9.54 IL6 TNF
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.52 IFNG TNF
27 negative regulation of lipid storage GO:0010888 9.49 IL6 TNF
28 positive regulation of neuroinflammatory response GO:0150078 9.43 IL6 TNF
29 humoral immune response GO:0006959 9.43 IFNG IL6 TNF
30 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.32 MIF TNF
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IFNG TNF
32 regulation of signaling receptor activity GO:0010469 9.02 IFNG IL6 MIF SPP1 TNF
33 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 IFNG TNF

Molecular functions related to Autoimmune Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL6 MIF SPP1 TNF

Sources for Autoimmune Myocarditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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