MCID: ATM089
MIFTS: 25

Autoimmune Neuropathy

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Neuropathy

MalaCards integrated aliases for Autoimmune Neuropathy:

Name: Autoimmune Neuropathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060499

Summaries for Autoimmune Neuropathy

Disease Ontology : 12 An autoimmune disease of centreal nervous system caused by an autoimmune response.

MalaCards based summary : Autoimmune Neuropathy is related to neuropathy and miller fisher syndrome. An important gene associated with Autoimmune Neuropathy is NFASC (Neurofascin), and among its related pathways/superpathways are Neuroscience and L1CAM interactions. Affiliated tissues include t cells.

Related Diseases for Autoimmune Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Type 1 Neuropathy
Hereditary Type 2 Neuropathy Neuropathy - Hereditary

Diseases related to Autoimmune Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuropathy 10.2
2 miller fisher syndrome 9.9 HMGA2 MAG
3 autoimmune peripheral neuropathy 9.8 CD1E MAG
4 peripheral nervous system disease 9.8 MAG NFASC
5 myeloma, multiple 9.7
6 rheumatic disease 9.7
7 polyradiculoneuropathy 9.6 CNTN1 MAG NFASC
8 demyelinating polyneuropathy 9.6 CNTN1 MAG NFASC
9 autoimmune disease of peripheral nervous system 9.6 CD1E HMGA2 MAG NFASC

Graphical network of the top 20 diseases related to Autoimmune Neuropathy:



Diseases related to Autoimmune Neuropathy

Symptoms & Phenotypes for Autoimmune Neuropathy

Drugs & Therapeutics for Autoimmune Neuropathy

Search Clinical Trials , NIH Clinical Center for Autoimmune Neuropathy

Genetic Tests for Autoimmune Neuropathy

Anatomical Context for Autoimmune Neuropathy

MalaCards organs/tissues related to Autoimmune Neuropathy:

41
T Cells

Publications for Autoimmune Neuropathy

Articles related to Autoimmune Neuropathy:

(show all 12)
# Title Authors Year
1
IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4<sup>+</sup>T Cell Migration. ( 29367208 )
2018
2
Acute painful autoimmune neuropathy: A variant of Guillain-BarrAc syndrome. ( 28667708 )
2017
3
Animal models of autoimmune neuropathy. ( 24615441 )
2014
4
Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background. ( 23850635 )
2013
5
Inflammatory autoimmune neuropathy, presumably induced by bortezomib, in a patient suffering from multiple myeloma. ( 21553020 )
2011
6
Peripheral autoimmune neuropathy assessed using corneal in vivo confocal microscopy. ( 19273761 )
2009
7
Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. ( 16237054 )
2005
8
Synthetic disialylgalactose immunoadsorbents deplete anti-GQ1b antibodies from autoimmune neuropathy sera. ( 14960498 )
2004
9
Rhesus anti-D immunoglobulin in chronic autoimmune neuropathy. ( 9696530 )
1998
10
Anti-GM1 ganglioside antibodies cloned from autoimmune neuropathy patients show diverse binding patterns in the rodent nervous system. ( 8786377 )
1996
11
Antibodies to GM1 and Gal(beta 1-3)GalNAc at the nodes of Ranvier in human and experimental autoimmune neuropathy. ( 8842022 )
1996
12
Experimental autoimmune neuropathy with anti-GM1 antibodies and immunoglobulin deposits at the nodes of Ranvier. ( 1767631 )
1991

Variations for Autoimmune Neuropathy

Expression for Autoimmune Neuropathy

Search GEO for disease gene expression data for Autoimmune Neuropathy.

Pathways for Autoimmune Neuropathy

Pathways related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 CNTNAP1 MAG NFASC
2
Show member pathways
11.23 CNTN1 CNTNAP1 NFASC
3 11.08 CNTN1 CNTNAP1 MAG NFASC

GO Terms for Autoimmune Neuropathy

Cellular components related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 paranodal junction GO:0033010 9.26 CNTNAP1 NFASC
2 myelin sheath GO:0043209 9.26 CNTN1 CNTNAP1 MAG NFASC
3 septate junction GO:0005918 9.16 CNTNAP1 NFASC
4 paranode region of axon GO:0033270 8.8 CNTNAP1 MAG NFASC

Biological processes related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.62 CNTN1 CNTNAP1 MAG NFASC
2 neuron projection development GO:0031175 9.4 CNTN1 CNTNAP1
3 transmission of nerve impulse GO:0019226 9.37 MAG NFASC
4 central nervous system myelination GO:0022010 9.26 CNTNAP1 MAG
5 paranodal junction assembly GO:0030913 9.16 CNTNAP1 NFASC
6 protein localization to juxtaparanode region of axon GO:0071205 8.96 CNTNAP1 NFASC
7 protein localization to paranode region of axon GO:0002175 8.62 CNTNAP1 NFASC

Molecular functions related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.62 CNTN1 MAG

Sources for Autoimmune Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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