MCID: ATM089
MIFTS: 28

Autoimmune Neuropathy

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Autoimmune Neuropathy

MalaCards integrated aliases for Autoimmune Neuropathy:

Name: Autoimmune Neuropathy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060499

Summaries for Autoimmune Neuropathy

Disease Ontology : 12 An autoimmune disease of central nervous system caused by an autoimmune response.

MalaCards based summary : Autoimmune Neuropathy is related to neuropathy and multifocal motor neuropathy. An important gene associated with Autoimmune Neuropathy is ICOSLG (Inducible T Cell Costimulator Ligand), and among its related pathways/superpathways are Neuroscience and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Affiliated tissues include thymus, t cells and skin, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Autoimmune Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Neuropathies

Diseases related to Autoimmune Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 neuropathy 29.9 SPTBN4 PMP2 NFASC MPZ MAG GLDN
2 multifocal motor neuropathy 29.8 GLDN FCGR2B
3 polyneuropathy 29.8 NFASC MPZ MAG FCGR2B CNTN1
4 demyelinating polyneuropathy 29.7 NFASC MAG FCGR2B CNTN1
5 autoimmune peripheral neuropathy 29.5 PMP2 MPZ MAG ICOSLG CD86 CD4
6 neuritis 29.3 PMP2 MPZ MAG DPYSL5
7 peripheral nervous system disease 29.2 PMP2 NFASC MPZ MAG ICOSLG DPYSL5
8 miller fisher syndrome 29.1 NFASC MAG GLDN CNTNAP2 CNTN1
9 cerebral lymphoma 10.3 MAG CD4
10 mononeuritis of upper limb and mononeuritis multiplex 10.3 MAG CD4
11 mononeuritis multiplex 10.3 MAG CD4
12 hereditary neuropathies 10.3 MPZ MAG
13 wallerian degeneration 10.2 MPZ MAG
14 caplan's syndrome 10.2 FOXP3 CD4
15 autoimmune atherosclerosis 10.2 FOXP3 CD4
16 immunodeficiency with hyper-igm, type 3 10.2 ICOSLG CD86 CD4
17 acute proliferative glomerulonephritis 10.2 ICOSLG CD4
18 mononeuropathy 10.2 MPZ MAG CD4
19 hypertrophic neuropathy of dejerine-sottas 10.2 MPZ MAG CNTNAP1
20 immunodeficiency 16 10.2 ICOSLG CD4
21 charcot-marie-tooth disease, demyelinating, type 1d 10.2 PMP2 MPZ
22 chronic polyneuropathy 10.1 MAG FCGR2B
23 microsporidiosis 10.1 PMP2 CD4
24 pelizaeus-merzbacher disease 10.1 MPZ MAG CD4
25 neuroretinitis 10.1 DPYSL5 CD4
26 developmental and epileptic encephalopathy 5 10.1 SPTBN4 NFASC
27 dacryoadenitis 10.1 ICOSLG FOXP3 CD4
28 legume allergy 10.1 ICOSLG FOXP3 CD4
29 immunodeficiency 41 with lymphoproliferation and autoimmunity 10.1 FOXP3 CD4
30 fruit allergy 10.1 ICOSLG FOXP3 CD4
31 autoimmune disease of eyes, ear, nose and throat 10.1 ICOSLG FOXP3 CD4
32 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.1 ICOSLG FOXP3 CD4
33 rectal disease 10.1 ICOSLG FOXP3 CD4
34 spinocerebellar ataxia 5 10.1 SPTBN4 NFASC
35 immunodeficiency 20 10.1 ICOSLG FCGR2B
36 nasal cavity disease 10.1 ICOSLG FOXP3 CD4
37 autoimmune disease of endocrine system 10.1 ICOSLG FOXP3 CD4
38 orchitis 10.1 FOXP3 CD4
39 autoimmune disease of skin and connective tissue 10.1 ICOSLG FOXP3 CD4
40 nose disease 10.1 ICOSLG FOXP3 CD4
41 lymph node disease 10.1 ICOSLG FOXP3 CD4
42 hypersensitivity reaction type iv disease 10.1 ICOSLG FOXP3 CD4
43 b cell deficiency 10.1 ICOSLG FOXP3 CD4
44 guillain-barre syndrome 10.1
45 parasitic helminthiasis infectious disease 10.1 ICOSLG FOXP3 CD4
46 filarial elephantiasis 10.1 FOXP3 CD4
47 anal spasm 10.1 DPYSL5 CD4
48 uveal disease 10.1 ICOSLG FOXP3 CD4
49 immunodeficiency 31c 10.1 FOXP3 CD86
50 sarcoidosis 1 10.1 ICOSLG CD86 CD4

Graphical network of the top 20 diseases related to Autoimmune Neuropathy:



Diseases related to Autoimmune Neuropathy

Symptoms & Phenotypes for Autoimmune Neuropathy

MGI Mouse Phenotypes related to Autoimmune Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.77 CD86 CNTN1 CNTNAP1 CNTNAP2 DPYSL5 FCGR2B
2 nervous system MP:0003631 9.44 CD4 CD86 CNTN1 CNTNAP1 CNTNAP2 DPYSL5

Drugs & Therapeutics for Autoimmune Neuropathy

Search Clinical Trials , NIH Clinical Center for Autoimmune Neuropathy

Genetic Tests for Autoimmune Neuropathy

Anatomical Context for Autoimmune Neuropathy

MalaCards organs/tissues related to Autoimmune Neuropathy:

40
Thymus, T Cells, Skin, B Cells, Bone, Lymph Node, Spinal Cord

Publications for Autoimmune Neuropathy

Articles related to Autoimmune Neuropathy:

(show top 50) (show all 101)
# Title Authors PMID Year
1
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy. 61
33752705 2021
2
Safety and efficacy of CAR T cells in a patient with lymphoma and a coexisting autoimmune neuropathy. 61
33284942 2020
3
Toxemia in Human Naturally Acquired Botulism. 61
33202855 2020
4
Antiparanodal antibodies and IgG subclasses in acute autoimmune neuropathy. 61
32736337 2020
5
Screening for genetic mutations in patients with neuropathy without definite etiology is useful. 61
32399692 2020
6
Adjuvant rituximab improves sensory ataxia in CIDP-related Sjögren syndrome. 61
32847874 2020
7
Campylobacter Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study. 61
31941810 2020
8
On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q. 61
31878295 2019
9
Amphiphysin-IgG autoimmune neuropathy: A recognizable clinicopathologic syndrome. 61
31624089 2019
10
Anti-pan-neurofascin IgG3 as a marker of fulminant autoimmune neuropathy. 61
31454780 2019
11
Varicella Zoster Virus Encephalitis Mimicking Nivolumab-Induced Autoimmune Neuropathy in a Patient with Lung Cancer. 61
31345336 2019
12
Efficacy and Safety of Octagam® in Patients With Chronic Inflammatory Demyelinating Polyneuropathy. 61
30903535 2019
13
High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy. 61
30468863 2019
14
Intravenous immunoglobulins for rheumatic disorders and thromboembolic events-a case series and review of the literature. 61
30565202 2018
15
Extremely Painful Multifocal Acquired Predominant Axonal Sensorimotor Neuropathy of the Upper Limb. 61
29159899 2018
16
IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration. 61
29367208 2018
17
Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome. 61
28667708 2018
18
Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases. 61
29222126 2018
19
Nodes, paranodes and neuropathies. 61
28819062 2018
20
Neurofascin antibodies in autoimmune, genetic, and idiopathic neuropathies. 61
29187518 2018
21
[Bickerstaff's encephalitis]. 61
30132464 2018
22
Gangliosides and Autoimmune Peripheral Nerve Diseases. 61
29747820 2018
23
Transplanted human fecal microbiota enhanced Guillain Barré syndrome autoantibody responses after Campylobacter jejuni infection in C57BL/6 mice. 61
28789710 2017
24
Microarray screening of Guillain-Barré syndrome sera for antibodies to glycolipid complexes. 61
27790627 2016
25
[Chronic Inflammatory Demyelinating Polyneuropathy]. 61
27951607 2016
26
Terminal complement activation is increased and associated with disease severity in CIDP. 61
27648461 2016
27
Complete neurologic and cognitive recovery after plasmapheresis in a patient with chronic inflammatory demyelinating polyneuropathy after allogeneic hematopoietic stem cell transplantation. 61
26919852 2016
28
Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fcγ Receptor-Mediated Inflammation. 61
25926454 2015
29
Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli. 61
25530156 2015
30
3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5. 61
25172093 2015
31
Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity. 61
24220299 2014
32
Corneal sensitivity in chronic inflammatory demyelinating polyneuropathy. 61
24858016 2014
33
[Diabetes mellitus and autoimmune neuropathy]. 61
24523312 2014
34
Fcγ receptor-mediated inflammation inhibits axon regeneration. 61
24523933 2014
35
Intravenous immunoglobulin preparation attenuates neurological signs in rat experimental autoimmune neuritis with the suppression of macrophage inflammatory protein -1α expression. 61
24262701 2014
36
Animal models of autoimmune neuropathy. 61
24615441 2014
37
Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background. 61
23850635 2013
38
[Unilateral optic neuritis and Miller Fisher syndrome]. 61
23688610 2013
39
Chronic inflammatory demyelinating polyradiculoneuropathy. 61
23623582 2013
40
Antibodies to contactin-1 in chronic inflammatory demyelinating polyneuropathy. 61
23280477 2013
41
Comparison of commercial tests for detecting multiple anti-ganglioside autoantibodies in patients with well-characterized immune-mediated peripheral neuropathies. 61
24409662 2013
42
Chronic inflammatory demyelinating polyradiculoneuropathy: from bench to bedside. 61
23117943 2012
43
Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing. 61
22870198 2012
44
The case for autoimmunity in glaucoma. 61
20801114 2011
45
Advances in the diagnosis, pathogenesis and treatment of CIDP. 61
21844897 2011
46
Biomarkers in experimental models of antibody-mediated neuropathies. 61
21696502 2011
47
Inflammatory autoimmune neuropathy, presumably induced by bortezomib, in a patient suffering from multiple myeloma. 61
21553020 2011
48
Redefining the Guillain-Barré spectrum in children: neuroimaging findings of cranial nerve involvement. 61
21292802 2011
49
Antibodies against ganglioside complexes in Guillain-Barré syndrome and related disorders. 61
21214559 2011
50
Erythropoietin enhances nerve repair in anti-ganglioside antibody-mediated models of immune neuropathy. 61
22046448 2011

Variations for Autoimmune Neuropathy

Expression for Autoimmune Neuropathy

Search GEO for disease gene expression data for Autoimmune Neuropathy.

Pathways for Autoimmune Neuropathy

GO Terms for Autoimmune Neuropathy

Cellular components related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.25 SPTBN4 SIGLEC1 NFASC MPZ MAG ICOSLG
2 integral component of membrane GO:0016021 10.15 SIGLEC1 NFASC MPZ MAG ICOSLG GLDN
3 plasma membrane GO:0005886 10.1 SPTBN4 SIGLEC1 NFASC MPZ MAG ICOSLG
4 external side of plasma membrane GO:0009897 9.78 ICOSLG FCGR2B CD86 CD4
5 axon GO:0030424 9.65 SPTBN4 NFASC GLDN CNTNAP2 CNTNAP1
6 axon initial segment GO:0043194 9.46 SPTBN4 NFASC
7 node of Ranvier GO:0033268 9.43 SPTBN4 NFASC
8 myelin sheath GO:0043209 9.33 PMP2 MPZ MAG
9 paranode region of axon GO:0033270 9.13 SPTBN4 MAG CNTNAP1
10 paranodal junction GO:0033010 8.8 NFASC CNTNAP2 CNTNAP1

Biological processes related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection development GO:0031175 9.61 CNTNAP2 CNTNAP1 CNTN1
2 cell adhesion GO:0007155 9.5 SIGLEC1 NFASC MAG CNTNAP2 CNTNAP1 CNTN1
3 positive regulation of interleukin-4 production GO:0032753 9.48 FOXP3 CD86
4 negative regulation of interleukin-10 production GO:0032693 9.46 FOXP3 FCGR2B
5 T cell activation GO:0042110 9.43 ICOSLG FOXP3 CD4
6 negative regulation of immune response GO:0050777 9.4 FOXP3 FCGR2B
7 central nervous system myelination GO:0022010 9.37 MAG CNTNAP1
8 clustering of voltage-gated sodium channels GO:0045162 9.32 SPTBN4 GLDN
9 protein localization to juxtaparanode region of axon GO:0071205 9.16 CNTNAP2 CNTNAP1
10 transmission of nerve impulse GO:0019226 8.92 SPTBN4 NFASC MAG CNTNAP2

Sources for Autoimmune Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....