MCID: ATM089
MIFTS: 29

Autoimmune Neuropathy

Categories: Immune diseases, Neuronal diseases
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Aliases & Classifications for Autoimmune Neuropathy

MalaCards integrated aliases for Autoimmune Neuropathy:

Name: Autoimmune Neuropathy 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0060499

Summaries for Autoimmune Neuropathy

Disease Ontology: 11 An autoimmune disease of central nervous system caused by an autoimmune response.

MalaCards based summary: Autoimmune Neuropathy is related to neuropathy and polyneuropathy. An important gene associated with Autoimmune Neuropathy is NFASC (Neurofascin), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cells and Lineage-specific Markers. Affiliated tissues include t cells, b cells and lung, and related phenotypes are nervous system and behavior/neurological

Related Diseases for Autoimmune Neuropathy

Diseases in the Neuropathy family:

Autoimmune Neuropathy Hereditary Neuropathies

Diseases related to Autoimmune Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 neuropathy 30.6 PMP2 NFASC MPZ CNTNAP1
2 polyneuropathy 30.4 NFASC MPZ MAG CNTN1
3 polyradiculoneuropathy 29.9 PMP2 MPZ IL10
4 chronic inflammatory demyelinating polyradiculoneuropathy 29.8 NFASC MPZ MAG ICOSLG GLDN CNTNAP1
5 miller fisher syndrome 29.5 NFASC MAG LGI1 CNTNAP2 CNTN1
6 stiff-person syndrome 29.4 LGI1 IGLON5 DPYSL5 CNTNAP2
7 autoimmune disease 29.2 IL10 ICOSLG FOXP3 FCGR2B CD86
8 autoimmune peripheral neuropathy 29.2 PMP2 NFASC MPZ MAG ICOSLG CNTN1
9 neuritis 29.0 PMP2 MPZ MAG IL10 DPYSL5
10 demyelinating polyneuropathy 28.2 NFASC MPZ MAG LGI1 IGLON5 GLDN
11 peripheral nervous system disease 27.5 PMP2 NFASC MPZ MAG LGI1 IL10
12 ulnar neuropathy 10.3 MPZ CNTNAP1
13 hereditary neuropathies 10.3 MPZ MAG
14 thymic dysplasia 10.3 ICOSLG CD4
15 multiple cranial nerve palsy 10.3 CNTNAP1 CD4
16 cerebral lymphoma 10.3 MAG CD4
17 brachial plexus neuritis 10.2 NFASC LGI1
18 autoimmune cardiomyopathy 10.2 ICOSLG CD4
19 postinfectious encephalitis 10.2 LGI1 CNTNAP2
20 auditory agnosia 10.2 LGI1 CNTNAP2
21 autoimmune optic neuritis 10.2 MAG DPYSL5
22 transient global amnesia 10.2 LGI1 CNTNAP2
23 progressive relapsing multiple sclerosis 10.2 MAG ICOSLG CD4
24 recurrent hypersomnia 10.2 LGI1 IGLON5
25 dissociative amnesia 10.2 LGI1 CNTNAP2
26 kleine-levin hibernation syndrome 10.2 LGI1 IGLON5
27 pelizaeus-merzbacher disease 10.2 MPZ MAG CNTNAP1
28 hypertrophic neuropathy of dejerine-sottas 10.2 MPZ MAG CNTNAP1
29 plasma protein metabolism disease 10.2 MAG ICOSLG CD4
30 caplan's syndrome 10.2 FOXP3 CD4
31 guillain-barre syndrome, familial 10.2
32 mononeuropathy 10.2 MPZ MAG CD4
33 blood protein disease 10.2 MAG ICOSLG CD4
34 immunodeficiency with hyper-igm, type 3 10.2 ICOSLG CD86 CD4
35 charcot-marie-tooth disease type 1g 10.2 PMP2 MPZ
36 drug psychosis 10.2 LGI1 CNTNAP2
37 elephantiasis 10.2 IL10 CD4
38 guillain-barre syndrome 10.1
39 neuroretinitis 10.1 DPYSL5 CD4
40 optic papillitis 10.1 DPYSL5 CD4
41 gallbladder small cell carcinoma 10.1 LGI1 CNTNAP2 CNTNAP1
42 encephalitozoonosis 10.1 PMP2 CD4
43 drug-induced mental disorder 10.1 LGI1 CNTNAP2
44 acute cervicitis 10.1 IL10 CD4
45 lymphocytic colitis 10.1 FOXP3 CD4
46 autoimmune gastritis 10.1 ICOSLG FOXP3 CD4
47 von economo's disease 10.1 LGI1 IGLON5 CNTNAP2
48 autoimmune polyendocrine syndrome type 1 10.1 ICOSLG FOXP3 CD4
49 autoimmune polyendocrine syndrome 10.1 ICOSLG FOXP3 CD4
50 acute retinal necrosis syndrome 10.1 IL10 CD4

Graphical network of the top 20 diseases related to Autoimmune Neuropathy:



Diseases related to Autoimmune Neuropathy

Symptoms & Phenotypes for Autoimmune Neuropathy

MGI Mouse Phenotypes related to Autoimmune Neuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.83 CD4 CD86 CNTN1 CNTNAP1 CNTNAP2 DPYSL5
2 behavior/neurological MP:0005386 9.5 CD86 CNTN1 CNTNAP1 CNTNAP2 DPYSL5 FCGR2B

Drugs & Therapeutics for Autoimmune Neuropathy

Search Clinical Trials, NIH Clinical Center for Autoimmune Neuropathy

Genetic Tests for Autoimmune Neuropathy

Anatomical Context for Autoimmune Neuropathy

Organs/tissues related to Autoimmune Neuropathy:

MalaCards : T Cells, B Cells, Lung, Skin

Publications for Autoimmune Neuropathy

Articles related to Autoimmune Neuropathy:

(show top 50) (show all 107)
# Title Authors PMID Year
1
Anti-pan-neurofascin antibodies induce subclass-related complement activation and nodo-paranodal damage. 62
36346134 2022
2
Campylobacter jejuni and Postinfectious Autoimmune Diseases: A Proof of Concept in Glycobiology. 62
36137262 2022
3
Potential therapeutic strategies in chronic inflammatory demyelinating polyradiculoneuropathy. 62
34999243 2022
4
Guillain-Barre syndrome in Mexico: clinical features and validation of Brighton Collaboration Group criteria. 62
35383873 2022
5
IgG1 pan-neurofascin antibodies identify a severe yet treatable neuropathy with a high mortality. 62
34400540 2021
6
Guillain-Barré Syndrome and Other Acute Polyneuropathies. 62
33858613 2021
7
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy. 62
33752705 2021
8
Safety and efficacy of CAR T cells in a patient with lymphoma and a coexisting autoimmune neuropathy. 62
33284942 2020
9
Toxemia in Human Naturally Acquired Botulism. 62
33202855 2020
10
Screening for genetic mutations in patients with neuropathy without definite etiology is useful. 62
32399692 2020
11
Antiparanodal antibodies and IgG subclasses in acute autoimmune neuropathy. 62
32736337 2020
12
Adjuvant rituximab improves sensory ataxia in CIDP-related Sjögren syndrome. 62
32847874 2020
13
Campylobacter Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study. 62
31941810 2020
14
On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q. 62
31878295 2019
15
Amphiphysin-IgG autoimmune neuropathy: A recognizable clinicopathologic syndrome. 62
31624089 2019
16
Anti-pan-neurofascin IgG3 as a marker of fulminant autoimmune neuropathy. 62
31454780 2019
17
Varicella Zoster Virus Encephalitis Mimicking Nivolumab-Induced Autoimmune Neuropathy in a Patient with Lung Cancer. 62
31345336 2019
18
Efficacy and Safety of Octagam® in Patients With Chronic Inflammatory Demyelinating Polyneuropathy. 62
30903535 2019
19
High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy. 62
30468863 2019
20
Intravenous immunoglobulins for rheumatic disorders and thromboembolic events-a case series and review of the literature. 62
30565202 2018
21
Extremely Painful Multifocal Acquired Predominant Axonal Sensorimotor Neuropathy of the Upper Limb. 62
29159899 2018
22
IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration. 62
29367208 2018
23
Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome. 62
28667708 2018
24
Gangliosides and Autoimmune Peripheral Nerve Diseases. 62
29747820 2018
25
Neurofascin antibodies in autoimmune, genetic, and idiopathic neuropathies. 62
29187518 2018
26
Autoimmune CRMP5 neuropathy phenotype and outcome defined from 105 cases. 62
29222126 2018
27
[Bickerstaff's encephalitis]. 62
30132464 2018
28
Nodes, paranodes and neuropathies. 62
28819062 2018
29
Transplanted human fecal microbiota enhanced Guillain Barré syndrome autoantibody responses after Campylobacter jejuni infection in C57BL/6 mice. 62
28789710 2017
30
Microarray screening of Guillain-Barré syndrome sera for antibodies to glycolipid complexes. 62
27790627 2016
31
[Chronic Inflammatory Demyelinating Polyneuropathy]. 62
27951607 2016
32
Terminal complement activation is increased and associated with disease severity in CIDP. 62
27648461 2016
33
Complete neurologic and cognitive recovery after plasmapheresis in a patient with chronic inflammatory demyelinating polyneuropathy after allogeneic hematopoietic stem cell transplantation. 62
26919852 2016
34
Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fcγ Receptor-Mediated Inflammation. 62
25926454 2015
35
Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli. 62
25530156 2015
36
3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5. 62
25172093 2015
37
Corneal sensitivity in chronic inflammatory demyelinating polyneuropathy. 62
24858016 2014
38
Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity. 62
24220299 2014
39
[Diabetes mellitus and autoimmune neuropathy]. 62
24523312 2014
40
Fcγ receptor-mediated inflammation inhibits axon regeneration. 62
24523933 2014
41
Intravenous immunoglobulin preparation attenuates neurological signs in rat experimental autoimmune neuritis with the suppression of macrophage inflammatory protein -1α expression. 62
24262701 2014
42
Animal models of autoimmune neuropathy. 62
24615441 2014
43
Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background. 62
23850635 2013
44
[Unilateral optic neuritis and Miller Fisher syndrome]. 62
23688610 2013
45
Chronic inflammatory demyelinating polyradiculoneuropathy. 62
23623582 2013
46
Antibodies to contactin-1 in chronic inflammatory demyelinating polyneuropathy. 62
23280477 2013
47
Comparison of commercial tests for detecting multiple anti-ganglioside autoantibodies in patients with well-characterized immune-mediated peripheral neuropathies. 62
24409662 2013
48
Chronic inflammatory demyelinating polyradiculoneuropathy: from bench to bedside. 62
23117943 2012
49
Avian resistance to Campylobacter jejuni colonization is associated with an intestinal immunogene expression signature identified by mRNA sequencing. 62
22870198 2012
50
Advances in the diagnosis, pathogenesis and treatment of CIDP. 62
21844897 2011

Variations for Autoimmune Neuropathy

Expression for Autoimmune Neuropathy

Search GEO for disease gene expression data for Autoimmune Neuropathy.

Pathways for Autoimmune Neuropathy

Pathways related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.2 NFASC MAG CNTNAP2 CNTNAP1
2 11.56 IL10 CD86 CD4
3
Show member pathways
11.43 IL10 CD86 CD4
4 11.3 IL10 FOXP3 CD86
5 11.18 IL10 CD86 CD4
6 10.59 IL10 FOXP3 CD86 CD4
7 9.73 FOXP3 CD86

GO Terms for Autoimmune Neuropathy

Cellular components related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.65 NFASC NCDN GLDN CNTNAP2 CNTNAP1 CNTN1
2 myelin sheath GO:0043209 9.63 PMP2 MPZ MAG
3 paranodal junction GO:0033010 9.1 NFASC CNTNAP2 CNTNAP1

Biological processes related to Autoimmune Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.2 NFASC MAG CNTNAP2 CNTNAP1 CNTN1 CD4
2 axon guidance GO:0007411 10.08 NFASC LGI1 DPYSL5 CNTN1
3 T cell activation GO:0042110 9.91 ICOSLG FOXP3 CD4
4 negative regulation of T cell proliferation GO:0042130 9.85 CD86 FOXP3 IL10
5 negative regulation of cytokine production GO:0001818 9.73 IL10 FOXP3 FCGR2B
6 central nervous system myelin formation GO:0032289 9.71 MAG CNTN1
7 transmission of nerve impulse GO:0019226 9.63 NFASC MAG CNTNAP2
8 protein localization to juxtaparanode region of axon GO:0071205 9.62 CNTNAP2 CNTNAP1
9 neuron projection development GO:0031175 9.56 NCDN LGI1 CNTNAP2 CNTNAP1 CNTN1
10 myelination GO:0042552 9.17 NFASC MPZ MAG CNTNAP1 CNTN1

Sources for Autoimmune Neuropathy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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