MCID: ATM100
MIFTS: 39

Autoimmune Optic Neuritis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Optic Neuritis

MalaCards integrated aliases for Autoimmune Optic Neuritis:

Name: Autoimmune Optic Neuritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040089

Summaries for Autoimmune Optic Neuritis

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that is located in the neuron projection bundle connecting eye with brain.

MalaCards based summary : Autoimmune Optic Neuritis is related to neuritis and optic neuritis. An important gene associated with Autoimmune Optic Neuritis is MOG (Myelin Oligodendrocyte Glycoprotein), and among its related pathways/superpathways are Th1 Differentiation Pathway and Neuroscience. The drugs Epoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and t cells, and related phenotypes are no effect and hematopoietic system

Related Diseases for Autoimmune Optic Neuritis

Diseases in the Optic Neuritis family:

Autoimmune Optic Neuritis

Diseases related to Autoimmune Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 neuritis 31.5 AQP4 MBP MOG
2 optic neuritis 31.3 AQP4 CNTF MBP MOG
3 allergic encephalomyelitis 10.3 MBP MOG
4 autoimmune atherosclerosis 10.3 FOXP3 IL10
5 acute transverse myelitis 10.3 AQP4 IL10
6 lung oat cell carcinoma 10.3 CALCA OAT
7 alexia 10.3 AQP4 MBP
8 balo concentric sclerosis 10.3 AQP4 MBP MOG
9 internuclear ophthalmoplegia 10.3 AQP4 MBP MOG
10 central pontine myelinolysis 10.3 AQP4 MBP
11 cranial nerve disease 10.2 AQP4 MBP MOG
12 palladium allergic contact dermatitis 10.2 IL10 IL17A
13 primary progressive multiple sclerosis 10.2 IL10 MBP MOG
14 peripheral nervous system disease 10.2 AQP4 MBP MOG
15 traumatic brain injury 10.2 AQP4 IL10 MBP
16 autoimmune enteropathy 10.2 FOXP3 IL17A
17 neurosyphilis 10.2 IL10 IL17A
18 spinal cord disease 10.2 AQP4 DPYSL5 MBP MOG
19 optic nerve disease 10.2 AQP4 DPYSL5 MBP MOG
20 autoimmune disease of eyes, ear, nose and throat 10.2 FOXP3 IL10 IL17A
21 childhood disintegrative disease 10.1 APP MBP
22 uveal disease 10.1 IL10 IL17A OAT
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 FOXP3 IL10 IL17A
24 tropical spastic paraparesis 10.1 FOXP3 IL10 IL17A
25 autoimmune disease of musculoskeletal system 10.1 FOXP3 IL10 IL17A
26 upper respiratory tract disease 10.1 FOXP3 IL10 IL17A
27 polyradiculoneuropathy 10.1 IL10 IL17A MBP
28 acute disseminated encephalomyelitis 10.1 AQP4 IL10 MBP MOG
29 intestinal disease 10.1 FOXP3 IL10 IL17A
30 retinitis 10.1
31 myelitis 10.1 AQP4 IL17A MBP MOG
32 neuromyelitis optica 10.1 AQP4 IL17A MBP MOG
33 transverse myelitis 10.0 AQP4 IL10 IL17A MBP
34 neuropathy, hereditary sensory and autonomic, type vi 10.0 AIF1 LCN2
35 gastrointestinal system disease 10.0 FOXP3 IL10 IL17A
36 apple allergy 10.0 FOXP3 IL10
37 neuroretinitis 10.0 AQP4 DPYSL5 MOG RCVRN
38 retinal degeneration 9.9
39 autoimmune disease 9.9 FOXP3 IL10 IL17A MBP MOG
40 demyelinating disease 9.9 AQP4 IL10 IL17A MBP MOG
41 dermatitis, atopic 9.9 FOXP3 IL10 IL17A
42 relapsing-remitting multiple sclerosis 9.8 AQP4 FOXP3 IL10 IL17A MBP MOG
43 immune system disease 9.8 AQP4 FOXP3 IL10 IL17A MBP MOG
44 nervous system disease 9.7 APP AQP4 IL10 MBP MOG PRNP
45 central nervous system disease 9.6 APP AQP4 CNTF IL17A MBP MOG
46 autoimmune disease of central nervous system 9.3 AQP4 CD80 FOXP3 IL10 IL17A MBP
47 multiple sclerosis 9.3 AQP4 CD80 FOXP3 IL10 IL17A MBP

Graphical network of the top 20 diseases related to Autoimmune Optic Neuritis:



Diseases related to Autoimmune Optic Neuritis

Symptoms & Phenotypes for Autoimmune Optic Neuritis

GenomeRNAi Phenotypes related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 AIF1 APP AQP4 CALCA CAST CD80

MGI Mouse Phenotypes related to Autoimmune Optic Neuritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 AIF1 APP AQP4 CAST CD80 CNTF
2 behavior/neurological MP:0005386 10.21 APP AQP4 CAST CNTF CNTNAP1 DPYSL5
3 homeostasis/metabolism MP:0005376 10.17 AIF1 APP AQP4 CAST CNTF DNTT
4 growth/size/body region MP:0005378 10.14 APP AQP4 CNTNAP1 FOXP3 IL10 IL17A
5 immune system MP:0005387 10.13 AIF1 APP AQP4 CAST CD80 CNTF
6 nervous system MP:0003631 10 AIF1 APP AQP4 CAST CD80 CNTF
7 no phenotypic analysis MP:0003012 9.56 APP AQP4 CNTF FOXP3 IL10 IL17A
8 vision/eye MP:0005391 9.32 AIF1 AQP4 CNTNAP1 FOXP3 IL10 MBP

Drugs & Therapeutics for Autoimmune Optic Neuritis

Drugs for Autoimmune Optic Neuritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Epoetin alfa Phase 3,Phase 2 113427-24-0
2 Hematinics Phase 3,Phase 2
3
Hydrochlorothiazide Approved, Vet_approved Phase 2 58-93-5 3639
4
Amiloride Approved Phase 2 2016-88-8, 2609-46-3 16231
5
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
8
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
9
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
10 Natriuretic Agents Phase 2
11 Amiloride, hydrochlorothiazide drug combination Phase 2
12 Sodium Channel Blockers Phase 2
13 Epithelial Sodium Channel Blockers Phase 2
14 Antihypertensive Agents Phase 2
15 diuretics Phase 2
16 Sodium Chloride Symporter Inhibitors Phase 2
17 Diuretics, Potassium Sparing Phase 2
18 Gastrointestinal Agents Phase 2
19 glucocorticoids Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Protective Agents Phase 2
22 Neuroprotective Agents Phase 2
23 Antiemetics Phase 2
24 Methylprednisolone Acetate Phase 2
25 Antineoplastic Agents, Hormonal Phase 2
26 Hormone Antagonists Phase 2
27 Autonomic Agents Phase 2
28 Hormones Phase 2
29 Anti-Inflammatory Agents Phase 2
30 Peripheral Nervous System Agents Phase 2
31 Prednisolone acetate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial Active, not recruiting NCT01962571 Phase 3 Erythropoietin alfa;Placebo
2 Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve Unknown status NCT01879527 Phase 2 Amiloride hydrochlorothiazide;Sugar pill
3 Safety and Efficacy Study of Erythropoietin as add-on Therapy of Methylprednisolone to Treat Acute Optic Neuritis Completed NCT00355095 Phase 2 Erythropoietin
4 Repetitive Transorbital Alternating Current Stimulation in Acute Autoimmune Optic Neuritis Not yet recruiting NCT03862313 Not Applicable

Search NIH Clinical Center for Autoimmune Optic Neuritis

Genetic Tests for Autoimmune Optic Neuritis

Anatomical Context for Autoimmune Optic Neuritis

MalaCards organs/tissues related to Autoimmune Optic Neuritis:

42
Eye, Brain, T Cells, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Optic Neuritis:

20
The Neuron Projection Bundle Connecting Eye

Publications for Autoimmune Optic Neuritis

Articles related to Autoimmune Optic Neuritis:

(show all 35)
# Title Authors Year
1
Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. ( 30578556 )
2019
2
Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis. ( 29444299 )
2018
3
Exploring experimental autoimmune optic neuritis using multimodal imaging. ( 29627590 )
2018
4
Selective Vulnerability of αOFF Retinal Ganglion Cells during Onset of Autoimmune Optic Neuritis. ( 30075244 )
2018
5
Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation. ( 28114593 )
2017
6
Neuroprotective effects of gypenosides in experimental autoimmune optic neuritis. ( 28503425 )
2017
7
Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered APP Cleavage in Neurons and Up-Regulation of p53. ( 26426258 )
2015
8
Retinoic acid receptor stimulation ameliorates experimental autoimmune optic neuritis. ( 24612001 )
2015
9
Roles of Treg/Th17 Cell Imbalance and Neuronal Damage in the Visual Dysfunction Observed in Experimental Autoimmune Optic Neuritis Chronologically. ( 26318182 )
2015
10
Small-cell lung carcinoma presenting as paraneoplastic autoimmune optic neuritis with retinitis. ( 24771190 )
2014
11
N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic neuritis. ( 24806299 )
2014
12
Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis. ( 23860028 )
2013
13
Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod. ( 23609767 )
2013
14
An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis. ( 22131393 )
2012
15
Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related Peptide gene. ( 22807299 )
2012
16
Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis. ( 23033382 )
2012
17
Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice. ( 22167100 )
2012
18
Visual functional and histopathological correlation in experimental autoimmune optic neuritis. ( 22969072 )
2012
19
Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis. ( 21641403 )
2011
20
Analysis of the pathogenesis of experimental autoimmune optic neuritis. ( 20981263 )
2011
21
Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis. ( 21215462 )
2011
22
Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis. ( 19670438 )
2009
23
Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles. ( 18335521 )
2008
24
Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis. ( 18037506 )
2008
25
Bilateral autoimmune optic neuritis and vitreitis related to CRMP-5-IgG: intravitreal triamcinolone acetonide therapy of four eyes. ( 17721501 )
2008
26
Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. ( 18832577 )
2008
27
Autoimmune optic neuritis in the common marmoset monkey: comparison of visual evoked potentials with MRI and histopathology. ( 18450589 )
2008
28
Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. ( 16828169 )
2006
29
Simvastatin treatment does not protect retinal ganglion cells from degeneration in a rat model of autoimmune optic neuritis. ( 15817275 )
2005
30
HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis. ( 16242630 )
2005
31
Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats. ( 15605985 )
2004
32
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. ( 12732654 )
2003
33
Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. ( 12838519 )
2003
34
Autoimmune optic neuritis: a potentially treatable form of visual loss. ( 3592470 )
1986
35
Oligoclonal banding in autoimmune optic neuritis. ( 7120622 )
1982

Variations for Autoimmune Optic Neuritis

Expression for Autoimmune Optic Neuritis

Search GEO for disease gene expression data for Autoimmune Optic Neuritis.

Pathways for Autoimmune Optic Neuritis

Pathways related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.66 CD80 IL10 IL17A
2 11.63 APP CALCA CAST CNTNAP1 MBP PRNP
3 11.58 AIF1 AQP4 MBP
4 11.49 IL10 IL17A LCN2
5 11.18 CD80 IL10 IL17A
6 10.79 CD80 FOXP3 IL10

GO Terms for Autoimmune Optic Neuritis

Biological processes related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.55 CD80 CNTF IL10 IL17A LCN2
2 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.54 APP PRNP
3 positive regulation of T cell migration GO:2000406 9.52 AIF1 APP
4 cellular copper ion homeostasis GO:0006878 9.51 APP PRNP
5 negative regulation of interleukin-2 production GO:0032703 9.49 FOXP3 PRNP
6 negative regulation of interleukin-17 production GO:0032700 9.48 FOXP3 PRNP
7 negative regulation of activated T cell proliferation GO:0046007 9.46 FOXP3 PRNP
8 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.43 IL10 MBP
9 astrocyte activation GO:0048143 9.4 APP CNTF
10 negative regulation of long-term synaptic potentiation GO:1900272 9.37 APP PRNP
11 neuron projection maintenance GO:1990535 9.32 APP PRNP
12 modulation of age-related behavioral decline GO:0090647 9.26 APP PRNP
13 negative regulation of interferon-gamma production GO:0032689 9.13 FOXP3 IL10 PRNP
14 negative regulation of T cell proliferation GO:0042130 8.92 CD80 FOXP3 IL10 MARCH7

Molecular functions related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.92 CAST LCN2 MBP PRNP

Sources for Autoimmune Optic Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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