MCID: ATM100
MIFTS: 39

Autoimmune Optic Neuritis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Optic Neuritis

MalaCards integrated aliases for Autoimmune Optic Neuritis:

Name: Autoimmune Optic Neuritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040089

Summaries for Autoimmune Optic Neuritis

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that is located in the neuron projection bundle connecting eye with brain.

MalaCards based summary : Autoimmune Optic Neuritis is related to neuritis and optic neuritis. An important gene associated with Autoimmune Optic Neuritis is MOG (Myelin Oligodendrocyte Glycoprotein), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drugs Hematinics and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and t cells, and related phenotypes are hematopoietic system and behavior/neurological

Related Diseases for Autoimmune Optic Neuritis

Diseases in the Optic Neuritis family:

Autoimmune Optic Neuritis

Diseases related to Autoimmune Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 neuritis 31.3 AQP4 MBP MOG
2 optic neuritis 31.1 AQP4 CNTF MBP MOG
3 allergic encephalomyelitis 10.2 MBP MOG
4 autoimmune atherosclerosis 10.2 FOXP3 IL10
5 acute transverse myelitis 10.2 AQP4 IL10
6 alexia 10.2 AQP4 MBP
7 central pontine myelinolysis 10.2 AQP4 MBP
8 balo concentric sclerosis 10.2 AQP4 MBP MOG
9 internuclear ophthalmoplegia 10.2 AQP4 MBP MOG
10 palladium allergic contact dermatitis 10.1 IL10 IL17A
11 cranial nerve disease 10.1 AQP4 MBP MOG
12 autoimmune enteropathy 10.1 FOXP3 IL17A
13 childhood disintegrative disease 10.1 APP MBP
14 viral encephalitis 10.1 IL10 MBP MOG
15 neurosyphilis 10.1 IL10 IL17A
16 primary progressive multiple sclerosis 10.1 IL10 MBP MOG
17 peripheral nervous system disease 10.1 AQP4 MBP MOG
18 apple allergy 10.1 FOXP3 IL10
19 traumatic brain injury 10.1 AQP4 IL10 MBP
20 panencephalitis, subacute sclerosing 10.1 MBP MOG
21 autoimmune disease of eyes, ear, nose and throat 10.1 FOXP3 IL10 IL17A
22 spinal cord disease 10.1 AQP4 DPYSL5 MBP MOG
23 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 FOXP3 IL10 IL17A
24 optic nerve disease 10.1 AQP4 DPYSL5 MBP MOG
25 uveal disease 10.1 IL10 IL17A OAT
26 tropical spastic paraparesis 10.1 FOXP3 IL10 IL17A
27 autoimmune disease of musculoskeletal system 10.1 FOXP3 IL10 IL17A
28 upper respiratory tract disease 10.1 FOXP3 IL10 IL17A
29 intestinal disease 10.1 FOXP3 IL10 IL17A
30 polyradiculoneuropathy 10.1 IL10 IL17A MBP
31 retinitis 10.1
32 acute disseminated encephalomyelitis 10.0 AQP4 IL10 MBP MOG
33 myelitis 10.0 AQP4 IL17A MBP MOG
34 neuromyelitis optica 10.0 AQP4 IL17A MBP MOG
35 transverse myelitis 10.0 AQP4 IL10 IL17A MBP
36 neuropathy, hereditary sensory and autonomic, type vi 10.0 AIF1 LCN2
37 bacterial infectious disease 10.0 IL10 IL17A ITGAM
38 autoimmune disease 9.9 FOXP3 IL10 IL17A MBP MOG
39 leishmaniasis 9.9 FOXP3 IL10 IL17A ITGAM
40 retinal degeneration 9.9
41 demyelinating disease 9.9 AQP4 IL10 IL17A MBP MOG
42 neuroretinitis 9.9 AQP4 DPYSL5 MOG RCVRN
43 colitis 9.8 FOXP3 IL10 IL17A
44 autoimmune disease of central nervous system 9.8 AQP4 FOXP3 IL10 IL17A MBP MOG
45 autoimmune disease of the nervous system 9.8 AQP4 FOXP3 IL10 IL17A MBP MOG
46 relapsing-remitting multiple sclerosis 9.8 AQP4 FOXP3 IL10 IL17A MBP MOG
47 immune system disease 9.8 AQP4 FOXP3 IL10 IL17A MBP MOG
48 nervous system disease 9.8 APP AQP4 IL10 MBP MOG PRNP
49 amyotrophic lateral sclerosis 1 9.8 AIF1 APP CNTF PRNP
50 multiple sclerosis 9.7 AQP4 CNTF FOXP3 IL10 IL17A MBP

Graphical network of the top 20 diseases related to Autoimmune Optic Neuritis:



Diseases related to Autoimmune Optic Neuritis

Symptoms & Phenotypes for Autoimmune Optic Neuritis

MGI Mouse Phenotypes related to Autoimmune Optic Neuritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 AIF1 APP AQP4 CNTF DNTT FOXP3
2 behavior/neurological MP:0005386 10.17 APP AQP4 CNTF CNTNAP1 DPYSL5 FOXP3
3 homeostasis/metabolism MP:0005376 10.17 AIF1 APP AQP4 CNTF DNTT FOXP3
4 growth/size/body region MP:0005378 10.14 APP AQP4 CNTNAP1 FOXP3 IL10 IL17A
5 immune system MP:0005387 10.1 AIF1 APP AQP4 CNTF DNTT FOXP3
6 nervous system MP:0003631 9.97 AIF1 APP AQP4 CNTF CNTNAP1 DPYSL5
7 no phenotypic analysis MP:0003012 9.56 APP AQP4 CNTF FOXP3 IL10 IL17A
8 vision/eye MP:0005391 9.32 AIF1 AQP4 CNTNAP1 FOXP3 IL10 MBP

Drugs & Therapeutics for Autoimmune Optic Neuritis

Drugs for Autoimmune Optic Neuritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hematinics Phase 3,Phase 2
2 Epoetin alfa Phase 3,Phase 2 113427-24-0
3
Amiloride Approved Phase 2 2016-88-8, 2609-46-3 16231
4
Hydrochlorothiazide Approved, Vet_approved Phase 2 58-93-5 3639
5
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
8
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
9
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
10 Epithelial Sodium Channel Blockers Phase 2
11 Amiloride, hydrochlorothiazide drug combination Phase 2
12 Antihypertensive Agents Phase 2
13 Diuretics, Potassium Sparing Phase 2
14 Sodium Chloride Symporter Inhibitors Phase 2
15 Sodium Channel Blockers Phase 2
16 diuretics Phase 2
17 Natriuretic Agents Phase 2
18 Antineoplastic Agents, Hormonal Phase 2
19 Hormones Phase 2
20 Peripheral Nervous System Agents Phase 2
21 Anti-Inflammatory Agents Phase 2
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
23 Antiemetics Phase 2
24 Methylprednisolone acetate Phase 2
25 Prednisolone acetate Phase 2
26 Gastrointestinal Agents Phase 2
27 glucocorticoids Phase 2
28 Hormone Antagonists Phase 2
29 Protective Agents Phase 2
30 Autonomic Agents Phase 2
31 Neuroprotective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial Active, not recruiting NCT01962571 Phase 3 Erythropoietin alfa;Placebo
2 Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve Unknown status NCT01879527 Phase 2 Amiloride hydrochlorothiazide;Sugar pill
3 Safety and Efficacy Study of Erythropoietin as add-on Therapy of Methylprednisolone to Treat Acute Optic Neuritis Completed NCT00355095 Phase 2 Erythropoietin

Search NIH Clinical Center for Autoimmune Optic Neuritis

Genetic Tests for Autoimmune Optic Neuritis

Anatomical Context for Autoimmune Optic Neuritis

MalaCards organs/tissues related to Autoimmune Optic Neuritis:

41
Eye, Brain, T Cells, Lung, Spinal Cord

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Optic Neuritis:

19
The Neuron Projection Bundle Connecting Eye

Publications for Autoimmune Optic Neuritis

Articles related to Autoimmune Optic Neuritis:

(show all 34)
# Title Authors Year
1
Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis. ( 29444299 )
2018
2
Exploring experimental autoimmune optic neuritis using multimodal imaging. ( 29627590 )
2018
3
Selective Vulnerability of αOFF Retinal Ganglion Cells during Onset of Autoimmune Optic Neuritis. ( 30075244 )
2018
4
Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation. ( 28114593 )
2017
5
Neuroprotective effects of gypenosides in experimental autoimmune optic neuritis. ( 28503425 )
2017
6
Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered APP Cleavage in Neurons and Up-Regulation of p53. ( 26426258 )
2015
7
Retinoic acid receptor stimulation ameliorates experimental autoimmune optic neuritis. ( 24612001 )
2015
8
Roles of Treg/Th17 Cell Imbalance and Neuronal Damage in the Visual Dysfunction Observed in Experimental Autoimmune Optic Neuritis Chronologically. ( 26318182 )
2015
9
Small-cell lung carcinoma presenting as paraneoplastic autoimmune optic neuritis with retinitis. ( 24771190 )
2014
10
N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic neuritis. ( 24806299 )
2014
11
Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis. ( 23860028 )
2013
12
Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod. ( 23609767 )
2013
13
An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis. ( 22131393 )
2012
14
Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related Peptide gene. ( 22807299 )
2012
15
Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis. ( 23033382 )
2012
16
Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice. ( 22167100 )
2012
17
Visual functional and histopathological correlation in experimental autoimmune optic neuritis. ( 22969072 )
2012
18
Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis. ( 21641403 )
2011
19
Analysis of the pathogenesis of experimental autoimmune optic neuritis. ( 20981263 )
2011
20
Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis. ( 21215462 )
2011
21
Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis. ( 19670438 )
2009
22
Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles. ( 18335521 )
2008
23
Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis. ( 18037506 )
2008
24
Bilateral autoimmune optic neuritis and vitreitis related to CRMP-5-IgG: intravitreal triamcinolone acetonide therapy of four eyes. ( 17721501 )
2008
25
Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. ( 18832577 )
2008
26
Autoimmune optic neuritis in the common marmoset monkey: comparison of visual evoked potentials with MRI and histopathology. ( 18450589 )
2008
27
Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. ( 16828169 )
2006
28
Simvastatin treatment does not protect retinal ganglion cells from degeneration in a rat model of autoimmune optic neuritis. ( 15817275 )
2005
29
HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis. ( 16242630 )
2005
30
Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats. ( 15605985 )
2004
31
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. ( 12732654 )
2003
32
Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. ( 12838519 )
2003
33
Autoimmune optic neuritis: a potentially treatable form of visual loss. ( 3592470 )
1986
34
Oligoclonal banding in autoimmune optic neuritis. ( 7120622 )
1982

Variations for Autoimmune Optic Neuritis

Expression for Autoimmune Optic Neuritis

Search GEO for disease gene expression data for Autoimmune Optic Neuritis.

Pathways for Autoimmune Optic Neuritis

Pathways related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 APP CNTNAP1 ITGAM MBP PRNP
2 11.51 AIF1 AQP4 MBP
3 11.23 IL10 IL17A ITGAM
4 10.98 IL10 IL17A ITGAM LCN2

GO Terms for Autoimmune Optic Neuritis

Cellular components related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 AQP4 IL17A ITGAM MOG

Biological processes related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.74 APP LCN2 PRNP
2 positive regulation of interleukin-6 secretion GO:2000778 9.58 IL17A MBP
3 microglial cell activation GO:0001774 9.56 AIF1 ITGAM
4 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.55 APP PRNP
5 positive regulation of T cell migration GO:2000406 9.54 AIF1 APP
6 cellular copper ion homeostasis GO:0006878 9.52 APP PRNP
7 negative regulation of interleukin-2 production GO:0032703 9.51 FOXP3 PRNP
8 negative regulation of interleukin-17 production GO:0032700 9.49 FOXP3 PRNP
9 negative regulation of activated T cell proliferation GO:0046007 9.48 FOXP3 PRNP
10 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 IL10 MBP
11 astrocyte activation GO:0048143 9.43 APP CNTF
12 negative regulation of long-term synaptic potentiation GO:1900272 9.4 APP PRNP
13 neuron projection maintenance GO:1990535 9.37 APP PRNP
14 cytokine-mediated signaling pathway GO:0019221 9.35 CNTF IL10 IL17A ITGAM LCN2
15 negative regulation of T cell proliferation GO:0042130 9.33 FOXP3 IL10 MARCH7
16 positive regulation of microglial cell activation GO:1903980 9.32 APP ITGAM
17 modulation of age-related behavioral decline GO:0090647 9.26 APP PRNP
18 negative regulation of interferon-gamma production GO:0032689 8.8 FOXP3 IL10 PRNP

Molecular functions related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 LCN2 MBP PRNP

Sources for Autoimmune Optic Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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