MCID: ATM100
MIFTS: 30

Autoimmune Optic Neuritis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Optic Neuritis

MalaCards integrated aliases for Autoimmune Optic Neuritis:

Name: Autoimmune Optic Neuritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040089

Summaries for Autoimmune Optic Neuritis

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that is located in the neuron projection bundle connecting eye with brain.

MalaCards based summary : Autoimmune Optic Neuritis is related to allergic encephalomyelitis and neuritis. An important gene associated with Autoimmune Optic Neuritis is DPYSL5 (Dihydropyrimidinase Like 5), and among its related pathways/superpathways is Spinal Cord Injury. The drugs Hematinics and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include neuron projection bundle connecting eye, eye and brain, and related phenotypes are behavior/neurological and immune system

Related Diseases for Autoimmune Optic Neuritis

Diseases in the Optic Neuritis family:

Autoimmune Optic Neuritis

Diseases related to Autoimmune Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 allergic encephalomyelitis 31.1 MOG MBP
2 neuritis 30.5 MOG MBP CNTF AQP4
3 optic neuritis 30.2 MOG MBP DPYSL5 CNTF AQP4
4 demyelinating disease 29.7 MOG MBP CNTF AQP4
5 autoimmune disease 10.3
6 optic papillitis 10.3 MOG AQP4
7 neurosarcoidosis 10.3 MOG AQP4
8 acute retrobulbar neuritis 10.2 MBP AQP4
9 transverse myelitis 10.2 MBP AQP4
10 traumatic brain injury 10.2 MBP AQP4
11 acute hemorrhagic leukoencephalitis 10.2 MBP AQP4
12 central pontine myelinolysis 10.2 MBP AQP4
13 subacute sclerosing panencephalitis 10.1 MOG MBP
14 guillain-barre syndrome 10.1 MOG MBP
15 quadriplegia 10.1 MOG MBP
16 viral encephalitis 10.1 MOG MBP
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
18 neuroretinitis 10.1
19 retinitis 10.1
20 isolated optic neuritis 10.1
21 vascular myelopathy 10.1 MOG DPYSL5 AQP4
22 cerebral artery occlusion 10.1 CNTF AQP4
23 occlusion precerebral artery 10.0 MBP AIF1
24 encephalomalacia 10.0 MBP AIF1
25 balo concentric sclerosis 10.0 MOG MBP AQP4
26 leukoencephalopathy, hereditary diffuse, with spheroids 10.0 MBP AIF1
27 neuromyelitis optica 10.0 MOG MBP AQP4
28 relapsing-remitting multiple sclerosis 10.0 MOG MBP AQP4
29 lung cancer 9.9
30 myasthenia gravis 9.9
31 multiple sclerosis 2 9.9
32 small cell carcinoma 9.9
33 pertussis 9.9
34 retinal degeneration 9.9
35 autoimmune encephalitis 9.9
36 chronic pain 9.9
37 systemic autoimmune disease 9.9
38 thyroid carcinoma 9.9
39 primary progressive multiple sclerosis 9.9 MOG MBP
40 ectodermal dysplasia 1, hypohidrotic, x-linked 9.9 MBP AIF1
41 dysferlinopathy 9.9 MIP AQP4
42 early-onset sutural cataract 9.9 MIP CRYBA1
43 early-onset posterior polar cataract 9.9 MIP CRYBA1
44 early-onset lamellar cataract 9.9 MIP CRYBA1
45 hydrops, lactic acidosis, and sideroblastic anemia 9.9 MIP AQP4
46 retinal ischemia 9.9 CNTF AIF1
47 early-onset nuclear cataract 9.8 MIP CRYBA1
48 bullous keratopathy 9.8 MIP AQP4
49 optic nerve hypoplasia, bilateral 9.8 CNTF AIF1
50 internuclear ophthalmoplegia 9.8 MOG MBP DPYSL5 AQP4

Graphical network of the top 20 diseases related to Autoimmune Optic Neuritis:



Diseases related to Autoimmune Optic Neuritis

Symptoms & Phenotypes for Autoimmune Optic Neuritis

MGI Mouse Phenotypes related to Autoimmune Optic Neuritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 AQP4 CNTF DPYSL5 GABPB1 KCNJ10 MBP
2 immune system MP:0005387 9.7 AIF1 AQP4 CNTF GABPB1 KCNJ10 MBP
3 nervous system MP:0003631 9.61 AIF1 AQP4 CNTF CRYBA1 DPYSL5 GABPB1
4 vision/eye MP:0005391 9.17 AIF1 AQP4 CRYBA1 KCNJ10 MBP MIP

Drugs & Therapeutics for Autoimmune Optic Neuritis

Drugs for Autoimmune Optic Neuritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hematinics Phase 3
2 Epoetin alfa Phase 3 113427-24-0
3
Amiloride Approved Phase 2 2016-88-8, 2609-46-3 16231
4
Hydrochlorothiazide Approved, Vet_approved Phase 2 58-93-5 3639
5
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
8 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
9
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
10
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
11 Sodium Chloride Symporter Inhibitors Phase 2
12 Sodium Channel Blockers Phase 2
13 Antihypertensive Agents Phase 2
14 Amiloride, hydrochlorothiazide drug combination Phase 2
15 diuretics Phase 2
16 Diuretics, Potassium Sparing Phase 2
17 Methylprednisolone Acetate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial Completed NCT01962571 Phase 3 Erythropoietin alfa;Placebo
2 A Randomized, Placebo-Controlled, Double-Blind, Phase IIa Study of Amiloride in the Treatment of Acute Autoimmune Optic Neuritis Unknown status NCT01879527 Phase 2 Amiloride hydrochlorothiazide;Sugar pill
3 Double Blind, Placebo-controlled Study to Determine the Safety and Efficacy of Erythropoietin as an add-on Therapy of Methylprednisolone in Subjects With Acute Optic Neuritis (VISION PROTECT) Completed NCT00355095 Phase 2 Erythropoietin

Search NIH Clinical Center for Autoimmune Optic Neuritis

Genetic Tests for Autoimmune Optic Neuritis

Anatomical Context for Autoimmune Optic Neuritis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Optic Neuritis:

19
Neuron Projection Bundle Connecting Eye

MalaCards organs/tissues related to Autoimmune Optic Neuritis:

40
Eye, Brain, T Cells, Lung

Publications for Autoimmune Optic Neuritis

Articles related to Autoimmune Optic Neuritis:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Influence of retinal NMDA receptor activity during autoimmune optic neuritis. 61
32031240 2020
2
New actors in optic neuritis pathogenesis: An Editorial for "Influence of retinal NMDA receptor activity during autoimmune optic neuritis" on page 693. 61
32162696 2020
3
Gypenosides Prevent H2O2-Induced Retinal Ganglion Cell Apoptosis by Concurrently Suppressing the Neuronal Oxidative Stress and Inflammatory Response. 61
31897969 2020
4
Bilateral retinal pathology following a first-ever clinical episode of autoimmune optic neuritis. 61
31969471 2020
5
Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. 61
30578556 2019
6
Prophylactic Treatment with Intravenous Immunoglobulin Attenuates Experimental Optic Neuritis in Mice. 61
30713249 2019
7
Selective Vulnerability of αOFF Retinal Ganglion Cells during Onset of Autoimmune Optic Neuritis. 61
30075244 2018
8
Exploring experimental autoimmune optic neuritis using multimodal imaging. 61
29627590 2018
9
Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis. 61
29444299 2018
10
Prevalence of Myelin Oligodendrocyte Glycoprotein and Aquaporin-4-IgG in Patients in the Optic Neuritis Treatment Trial. 61
29470571 2018
11
Neuroprotective effects of gypenosides in experimental autoimmune optic neuritis. 61
28503425 2017
12
Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation. 61
28114593 2017
13
Roles of Treg/Th17 Cell Imbalance and Neuronal Damage in the Visual Dysfunction Observed in Experimental Autoimmune Optic Neuritis Chronologically. 61
26318182 2015
14
Retinoic acid receptor stimulation ameliorates experimental autoimmune optic neuritis. 61
24612001 2015
15
Pathological Involvement of Astrocyte-Derived Lipocalin-2 in the Demyelinating Optic Neuritis. 61
26047170 2015
16
Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered APP Cleavage in Neurons and Up-Regulation of p53. 61
26426258 2015
17
N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic neuritis. 61
24806299 2014
18
Hypothalamitis: a diagnostic and therapeutic challenge. 61
23640278 2014
19
Small-cell lung carcinoma presenting as paraneoplastic autoimmune optic neuritis with retinitis. 61
24771190 2014
20
Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis. 61
23860028 2013
21
Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod. 61
23609767 2013
22
[Optic neuritis--immunological approach to elucidate pathogenesis and develop innovative therapy]. 61
23631257 2013
23
[Anti-MOG antibody in different types of immune-mediated optic neuritis]. 61
23336409 2012
24
Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis. 61
23033382 2012
25
Visual functional and histopathological correlation in experimental autoimmune optic neuritis. 61
22969072 2012
26
Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related Peptide gene. 61
22807299 2012
27
Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice. 61
22167100 2012
28
An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis. 61
22131393 2012
29
Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis. 61
21641403 2011
30
Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis. 61
21215462 2011
31
Analysis of the pathogenesis of experimental autoimmune optic neuritis. 61
20981263 2011
32
Magnetic resonance imaging in acute optic neuritis in Singapore. 61
19816643 2009
33
Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis. 61
19670438 2009
34
Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. 61
18832577 2008
35
Bilateral autoimmune optic neuritis and vitreitis related to CRMP-5-IgG: intravitreal triamcinolone acetonide therapy of four eyes. 61
17721501 2008
36
Autoimmune optic neuritis in the common marmoset monkey: comparison of visual evoked potentials with MRI and histopathology. 61
18450589 2008
37
Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles. 61
18335521 2008
38
Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis. 61
18037506 2008
39
Microfluorimetry defines early axonal damage in a rat model of optic neuritis: a novel method targeting early CNS autoimmunity. 61
17719649 2007
40
Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. 61
16828169 2006
41
HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis. 61
16242630 2005
42
Simvastatin treatment does not protect retinal ganglion cells from degeneration in a rat model of autoimmune optic neuritis. 61
15817275 2005
43
Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats. 61
15605985 2004
44
Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. 61
12838519 2003
45
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. 61
12732654 2003
46
[Bilateral simultaneous acute amaurosis in neuritis nervi optici. Initial manifestation of encephalomyelitis disseminata]. 61
9643027 1998
47
[Atypical optic neuritis in systemic lupus erythematosus (SLE)]. 61
8587308 1995
48
Postinfectious hepatitis B optic neuritis. 61
8145999 1994
49
[Autoimmune optic neuritis]. 61
1553669 1992
50
Autoimmune optic neuritis: a potentially treatable form of visual loss. 61
3592470 1986

Variations for Autoimmune Optic Neuritis

Expression for Autoimmune Optic Neuritis

Search GEO for disease gene expression data for Autoimmune Optic Neuritis.

Pathways for Autoimmune Optic Neuritis

Pathways related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.88 MBP AQP4 AIF1

GO Terms for Autoimmune Optic Neuritis

Biological processes related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homotetramerization GO:0051289 9.32 MIP AQP4
2 lens development in camera-type eye GO:0002088 9.26 MIP CRYBA1
3 positive regulation of interleukin-6 secretion GO:2000778 9.16 MBP AIF1
4 visual perception GO:0007601 9.13 MIP KCNJ10 CRYBA1
5 water transport GO:0006833 8.62 MIP AQP4

Molecular functions related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.16 MIP AQP4
2 structural constituent of eye lens GO:0005212 8.96 MIP CRYBA1
3 water channel activity GO:0015250 8.62 MIP AQP4

Sources for Autoimmune Optic Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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