MCID: ATM100
MIFTS: 35

Autoimmune Optic Neuritis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Optic Neuritis

MalaCards integrated aliases for Autoimmune Optic Neuritis:

Name: Autoimmune Optic Neuritis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040089

Summaries for Autoimmune Optic Neuritis

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that is located in the neuron projection bundle connecting eye with brain.

MalaCards based summary : Autoimmune Optic Neuritis is related to neuritis and allergic encephalomyelitis. An important gene associated with Autoimmune Optic Neuritis is MOG (Myelin Oligodendrocyte Glycoprotein), and among its related pathways/superpathways are Th1 Differentiation Pathway and Neuroscience. The drugs Hematinics and Epoetin alfa have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and t cells, and related phenotypes are behavior/neurological and hematopoietic system

Related Diseases for Autoimmune Optic Neuritis

Diseases in the Optic Neuritis family:

Autoimmune Optic Neuritis

Diseases related to Autoimmune Optic Neuritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 neuritis 31.8 MOG MBP AQP4
2 allergic encephalomyelitis 31.6 MOG MBP
3 optic neuritis 31.5 MOG MBP CNTF AQP4
4 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.6 IL17A IL10 FOXP3
5 autoimmune disease 30.1 MOG MBP IL17A IL10 FOXP3
6 neuroretinitis 30.0 RCVRN MOG DPYSL5 AQP4
7 demyelinating disease 29.9 MOG MBP IL17A IL10 AQP4
8 autoimmune atherosclerosis 10.5 IL10 FOXP3
9 acute transverse myelitis 10.5 IL10 AQP4
10 lung oat cell carcinoma 10.4 OAT CALCA
11 balo concentric sclerosis 10.4 MOG MBP AQP4
12 internuclear ophthalmoplegia 10.4 MOG MBP AQP4
13 central pontine myelinolysis 10.4 MBP AQP4
14 cranial nerve disease 10.4 MOG MBP AQP4
15 alexia 10.4 MBP AQP4
16 palladium allergic contact dermatitis 10.3 IL17A IL10
17 primary progressive multiple sclerosis 10.3 MOG MBP IL10
18 autoimmune enteropathy 10.3 IL17A FOXP3
19 peripheral nervous system disease 10.3 MOG MBP AQP4
20 traumatic brain injury 10.3 MBP IL10 AQP4
21 neurosyphilis 10.3 IL17A IL10
22 childhood disintegrative disease 10.3 MBP APP
23 spinal cord disease 10.2 MOG MBP DPYSL5 AQP4
24 optic nerve disease 10.2 MOG MBP DPYSL5 AQP4
25 autoimmune disease of eyes, ear, nose and throat 10.2 IL17A IL10 FOXP3
26 uveal disease 10.2 OAT IL17A IL10
27 tropical spastic paraparesis 10.2 IL17A IL10 FOXP3
28 autoimmune disease of musculoskeletal system 10.2 IL17A IL10 FOXP3
29 upper respiratory tract disease 10.2 IL17A IL10 FOXP3
30 polyradiculoneuropathy 10.2 MBP IL17A IL10
31 intestinal disease 10.2 IL17A IL10 FOXP3
32 acute disseminated encephalomyelitis 10.2 MOG MBP IL10 AQP4
33 apple allergy 10.1 IL10 FOXP3
34 retinitis 10.1
35 isolated optic neuritis 10.1
36 gastrointestinal system disease 10.1 IL17A IL10 FOXP3
37 myelitis 10.1 MOG MBP IL17A AQP4
38 neuromyelitis optica 10.0 MOG MBP IL17A AQP4
39 panencephalitis, subacute sclerosing 10.0 MOG MBP
40 neuropathy, hereditary sensory and autonomic, type vi 10.0 LCN2 AIF1
41 transverse myelitis 10.0 MBP IL17A IL10 AQP4
42 lung cancer 9.9
43 myasthenia gravis 9.9
44 multiple sclerosis 2 9.9
45 small cell carcinoma 9.9
46 pertussis 9.9
47 retinal degeneration 9.9
48 autoimmune encephalitis 9.9
49 chronic pain 9.9
50 systemic autoimmune disease 9.9

Graphical network of the top 20 diseases related to Autoimmune Optic Neuritis:



Diseases related to Autoimmune Optic Neuritis

Symptoms & Phenotypes for Autoimmune Optic Neuritis

MGI Mouse Phenotypes related to Autoimmune Optic Neuritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.23 APP AQP4 CAST CNTF CNTNAP1 DPYSL5
2 hematopoietic system MP:0005397 10.21 AIF1 APP AQP4 CAST CD80 CNTF
3 growth/size/body region MP:0005378 10.14 APP AQP4 CNTNAP1 FOXP3 IL10 IL17A
4 cellular MP:0005384 10.13 APP CAST CD80 CNTF FOXP3 IL10
5 homeostasis/metabolism MP:0005376 10.13 AIF1 APP AQP4 CAST CNTF DNTT
6 immune system MP:0005387 10.1 AIF1 APP AQP4 CAST CD80 CNTF
7 nervous system MP:0003631 9.97 AIF1 APP AQP4 CAST CD80 CNTF
8 no phenotypic analysis MP:0003012 9.56 APP AQP4 CNTF FOXP3 IL10 IL17A
9 vision/eye MP:0005391 9.32 AIF1 AQP4 CNTNAP1 FOXP3 IL10 MBP

Drugs & Therapeutics for Autoimmune Optic Neuritis

Drugs for Autoimmune Optic Neuritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hematinics Phase 3
2 Epoetin alfa Phase 3 113427-24-0
3
Amiloride Approved Phase 2 2016-88-8, 2609-46-3 16231
4
Hydrochlorothiazide Approved, Vet_approved Phase 2 58-93-5 3639
5
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
6
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
8
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
9
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
10 Antihypertensive Agents Phase 2
11 Sodium Channel Blockers Phase 2
12 Sodium Chloride Symporter Inhibitors Phase 2
13 Diuretics, Potassium Sparing Phase 2
14 Natriuretic Agents Phase 2
15 diuretics Phase 2
16 Amiloride, hydrochlorothiazide drug combination Phase 2
17 Epithelial Sodium Channel Blockers Phase 2
18 Hormone Antagonists Phase 2
19 Antiemetics Phase 2
20 Gastrointestinal Agents Phase 2
21 Neuroprotective Agents Phase 2
22 Hormones Phase 2
23 Methylprednisolone Acetate Phase 2
24 glucocorticoids Phase 2
25 Anti-Inflammatory Agents Phase 2
26 Peripheral Nervous System Agents Phase 2
27 Protective Agents Phase 2
28 Antineoplastic Agents, Hormonal Phase 2
29 Autonomic Agents Phase 2
30 Prednisolone acetate Phase 2
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial Active, not recruiting NCT01962571 Phase 3 Erythropoietin alfa;Placebo
2 A Randomized, Placebo-Controlled, Double-Blind, Phase IIa Study of Amiloride in the Treatment of Acute Autoimmune Optic Neuritis Unknown status NCT01879527 Phase 2 Amiloride hydrochlorothiazide;Sugar pill
3 Double Blind, Placebo-controlled Study to Determine the Safety and Efficacy of Erythropoietin as an add-on Therapy of Methylprednisolone in Subjects With Acute Optic Neuritis (VISION PROTECT) Completed NCT00355095 Phase 2 Erythropoietin

Search NIH Clinical Center for Autoimmune Optic Neuritis

Genetic Tests for Autoimmune Optic Neuritis

Anatomical Context for Autoimmune Optic Neuritis

MalaCards organs/tissues related to Autoimmune Optic Neuritis:

41
Eye, Brain, T Cells, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Optic Neuritis:

19
Neuron Projection Bundle Connecting Eye

Publications for Autoimmune Optic Neuritis

Articles related to Autoimmune Optic Neuritis:

(show all 47)
# Title Authors PMID Year
1
Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis. 38
30578556 2019
2
Prophylactic Treatment with Intravenous Immunoglobulin Attenuates Experimental Optic Neuritis in Mice. 38
30713249 2019
3
Selective Vulnerability of αOFF Retinal Ganglion Cells during Onset of Autoimmune Optic Neuritis. 38
30075244 2018
4
Exploring experimental autoimmune optic neuritis using multimodal imaging. 38
29627590 2018
5
Early Nodal and Paranodal Disruption in Autoimmune Optic Neuritis. 38
29444299 2018
6
Prevalence of Myelin Oligodendrocyte Glycoprotein and Aquaporin-4-IgG in Patients in the Optic Neuritis Treatment Trial. 38
29470571 2018
7
Neuroprotective effects of gypenosides in experimental autoimmune optic neuritis. 38
28503425 2017
8
Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation. 38
28114593 2017
9
Roles of Treg/Th17 Cell Imbalance and Neuronal Damage in the Visual Dysfunction Observed in Experimental Autoimmune Optic Neuritis Chronologically. 38
26318182 2015
10
Retinoic acid receptor stimulation ameliorates experimental autoimmune optic neuritis. 38
24612001 2015
11
Pathological Involvement of Astrocyte-Derived Lipocalin-2 in the Demyelinating Optic Neuritis. 38
26047170 2015
12
Neurodegeneration in Autoimmune Optic Neuritis Is Associated with Altered APP Cleavage in Neurons and Up-Regulation of p53. 38
26426258 2015
13
N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic neuritis. 38
24806299 2014
14
Hypothalamitis: a diagnostic and therapeutic challenge. 38
23640278 2014
15
Small-cell lung carcinoma presenting as paraneoplastic autoimmune optic neuritis with retinitis. 38
24771190 2014
16
Calcium influx and calpain activation mediate preclinical retinal neurodegeneration in autoimmune optic neuritis. 38
23860028 2013
17
Suppression of experimental autoimmune optic neuritis by the novel agent fingolimod. 38
23609767 2013
18
[Optic neuritis--immunological approach to elucidate pathogenesis and develop innovative therapy]. 38
23631257 2013
19
[Anti-MOG antibody in different types of immune-mediated optic neuritis]. 38
23336409 2012
20
Interleukin-10 gene-transfected mature dendritic cells suppress murine experimental autoimmune optic neuritis. 38
23033382 2012
21
Visual functional and histopathological correlation in experimental autoimmune optic neuritis. 38
22969072 2012
22
Suppression of murine experimental autoimmune optic neuritis by mature dendritic cells transfected with calcitonin gene-related Peptide gene. 38
22807299 2012
23
An optical coherence tomography study on degeneration of retinal nerve fiber layer in rats with autoimmune optic neuritis. 38
22131393 2012
24
Neuroprotective effects of recombinant T-cell receptor ligand in autoimmune optic neuritis in HLA-DR2 mice. 38
22167100 2012
25
Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis. 38
21641403 2011
26
Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis. 38
21215462 2011
27
Analysis of the pathogenesis of experimental autoimmune optic neuritis. 38
20981263 2011
28
Magnetic resonance imaging in acute optic neuritis in Singapore. 38
19816643 2009
29
Role of n-type voltage-dependent calcium channels in autoimmune optic neuritis. 38
19670438 2009
30
Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. 38
18832577 2008
31
Bilateral autoimmune optic neuritis and vitreitis related to CRMP-5-IgG: intravitreal triamcinolone acetonide therapy of four eyes. 38
17721501 2008
32
Autoimmune optic neuritis in the common marmoset monkey: comparison of visual evoked potentials with MRI and histopathology. 38
18450589 2008
33
Transient 5-(4-phenylbutoxy)psoralen (PAP-1) treatment dissociates developing pathologies in autoimmune optic neuritis into two distinct pathology profiles. 38
18335521 2008
34
Strain-specific susceptibility for neurodegeneration in a rat model of autoimmune optic neuritis. 38
18037506 2008
35
Microfluorimetry defines early axonal damage in a rat model of optic neuritis: a novel method targeting early CNS autoimmunity. 38
17719649 2007
36
Retinal ganglion cell damage induced by spontaneous autoimmune optic neuritis in MOG-specific TCR transgenic mice. 38
16828169 2006
37
HIV-Tat-mediated Bcl-XL delivery protects retinal ganglion cells during experimental autoimmune optic neuritis. 38
16242630 2005
38
Simvastatin treatment does not protect retinal ganglion cells from degeneration in a rat model of autoimmune optic neuritis. 38
15817275 2005
39
Ciliary neurotrophic factor protects retinal ganglion cells from secondary cell death during acute autoimmune optic neuritis in rats. 38
15605985 2004
40
Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. 38
12838519 2003
41
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. 38
12732654 2003
42
[Bilateral simultaneous acute amaurosis in neuritis nervi optici. Initial manifestation of encephalomyelitis disseminata]. 38
9643027 1998
43
[Atypical optic neuritis in systemic lupus erythematosus (SLE)]. 38
8587308 1995
44
Postinfectious hepatitis B optic neuritis. 38
8145999 1994
45
[Autoimmune optic neuritis]. 38
1553669 1992
46
Autoimmune optic neuritis: a potentially treatable form of visual loss. 38
3592470 1986
47
Oligoclonal banding in autoimmune optic neuritis. 38
7120622 1982

Variations for Autoimmune Optic Neuritis

Expression for Autoimmune Optic Neuritis

Search GEO for disease gene expression data for Autoimmune Optic Neuritis.

Pathways for Autoimmune Optic Neuritis

Pathways related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.66 IL17A IL10 CD80
2 11.63 PRNP MBP CNTNAP1 CAST CALCA APP
3 11.58 MBP AQP4 AIF1
4 11.49 LCN2 IL17A IL10
5 11.18 IL17A IL10 CD80
6 10.79 IL10 FOXP3 CD80

GO Terms for Autoimmune Optic Neuritis

Cellular components related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 MOG IL17A CD80 AQP4

Biological processes related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.72 PRNP LCN2 APP
2 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.54 PRNP APP
3 positive regulation of T cell migration GO:2000406 9.52 APP AIF1
4 negative regulation of interleukin-2 production GO:0032703 9.51 PRNP FOXP3
5 cellular copper ion homeostasis GO:0006878 9.49 PRNP APP
6 negative regulation of interleukin-17 production GO:0032700 9.48 PRNP FOXP3
7 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 MBP IL10
8 negative regulation of activated T cell proliferation GO:0046007 9.43 PRNP FOXP3
9 neuron projection maintenance GO:1990535 9.4 PRNP APP
10 negative regulation of long-term synaptic potentiation GO:1900272 9.37 PRNP APP
11 cytokine-mediated signaling pathway GO:0019221 9.35 LCN2 IL17A IL10 CNTF CD80
12 negative regulation of T cell proliferation GO:0042130 9.33 IL10 FOXP3 CD80
13 astrocyte activation GO:0048143 9.32 CNTF APP
14 modulation of age-related behavioral decline GO:0090647 9.26 PRNP APP
15 negative regulation of interferon-gamma production GO:0032689 8.8 PRNP IL10 FOXP3

Molecular functions related to Autoimmune Optic Neuritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.92 PRNP MBP LCN2 CAST

Sources for Autoimmune Optic Neuritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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