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AIP
MCID: ATM024
MIFTS: 53

Autoimmune Pancreatitis (AIP)

Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Autoimmune Pancreatitis

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MalaCards integrated aliases for Autoimmune Pancreatitis:

Name: Autoimmune Pancreatitis 12 52 58 15 71
Lymphoplasmocytic Sclerosing Pancreatitis 52
Aip 58

Characteristics:

Orphanet epidemiological data:

58
autoimmune pancreatitis
Inheritance: Not applicable;

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Cancer diseases
Anatomical: Gastrointestinal diseases Bone diseases Immune diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare gastroenterological diseases
Rare systemic and rhumatological diseases


External Ids:

Disease Ontology 12 DOID:0040091
ICD10 via Orphanet 33 K86.1
UMLS via Orphanet 72 C2609129
Orphanet 58 ORPHA103919
UMLS 71 C2609129
Sources

Summaries for Autoimmune Pancreatitis

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NIH Rare Diseases : 52 Autoimmune pancreatitis affects the pancreas, a gland behind the stomach and in front of the spine, and can also affect the bile ducts, salivary glands, kidneys, and lymph nodes . It is thought to occur when the immune system mistakenly begins to attack these healthy body tissues , glands, and organs . Common signs and symptoms include painless jaundice , weight loss, and noncancerous masses in the pancreas and other organs. Treatment often involves corticosteroids . The condition may recur following treatment, and require additional therapy.

MalaCards based summary : Autoimmune Pancreatitis, also known as lymphoplasmocytic sclerosing pancreatitis, is related to pancreatitis and sialadenitis. An important gene associated with Autoimmune Pancreatitis is CA2 (Carbonic Anhydrase 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Immune response NFAT in immune response. The drugs rituximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include pancreas, pituitary and liver, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Disease Ontology : 12 An autoimmune disease of endocrine system that is located in the pancreas.

Wikipedia : 74 Autoimmune pancreatitis is an increasingly recognized type of chronic pancreatitis that can be difficult... more...

Sources

Related Diseases for Autoimmune Pancreatitis

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Diseases in the Pancreatitis family:

Pancreatitis, Hereditary Autoimmune Pancreatitis
Acute Pancreatitis Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2 Autoimmune Pancreatitis Type 1
Recurrent Acute Pancreatitis

Diseases related to Autoimmune Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 680)
# Related Disease Score Top Affiliating Genes
1 pancreatitis 31.7 TNF PRSS1 HRAS CFTR CA2 AMY2A
2 sialadenitis 31.2 TNFSF13B TNF CD4
3 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 TNFSF13B IL10 FOXP3 CTLA4
4 acute pancreatitis 30.7 TNF PRSS1 IL10 CFTR ALB
5 thyroiditis 30.6 TNF IL10 FOXP3 CTLA4
6 sclerosing cholangitis 30.6 TNF IL10 HLA-DRB1 CFTR CD40LG ALB
7 dacryoadenitis 30.5 IL10 FOXP3 CD4
8 exocrine pancreatic insufficiency 30.4 TNF CTLA4 CFTR
9 thrombocytopenic purpura, autoimmune 30.4 HLA-DRB1 CD40LG CD4
10 sjogren syndrome 30.4 TNFSF13B IL10 CD40LG CA2
11 colitis 30.3 TNF IL10 HLA-DRB1 FOXP3 CTLA4
12 graft-versus-host disease 30.2 TNF IL10 HLA-DRB1
13 cholangitis, primary sclerosing 30.2 TNF ENO1 CFTR CD40LG CD4 ALB
14 cholangitis 30.2 TNF IL10 HLA-DRB1 CTLA4 CFTR CD40LG
15 duodenal ulcer 30.2 TNF IL10 HLA-DRB1
16 vasculitis 30.2 TNFSF13B TNF CTLA4 CD40LG
17 sarcoidosis 1 30.2 TNF HLA-DRB1 CD40LG CD4
18 purpura 30.1 TNFSF13B TNF IL10 CD40LG
19 optic papillitis 30.1 CD40LG CD4
20 bronchiolitis 29.9 TNF IL10 CD40LG
21 lymphadenitis 29.9 TNF IL10 CD4
22 dermatitis herpetiformis 29.9 TNF IL10 CD40LG
23 dermatitis 29.8 TNF IL10 FOXP3 CTLA4
24 crohn's disease 29.8 TNF IL10 HLA-DRB1 CD4 ALB
25 anemia, autoimmune hemolytic 29.8 TNFSF13B FOXP3 CTLA4 CD40LG CD4
26 thrombocytopenia due to platelet alloimmunization 29.8 TNFSF13B IL10 CD40LG CD4
27 myasthenia gravis 29.7 TNFSF13B TNF IL10 CTLA4
28 pancreatic adenocarcinoma 29.7 TNF PRSS1 IL10 HRAS ENO1 CFTR
29 rhinitis 29.7 TNF IL10 FOXP3 ALB
30 polyradiculoneuropathy 29.7 IL10 HLA-DRB1 CD40LG ALB
31 pyelonephritis 29.6 TNF IL10 ALB
32 duodenitis 29.6 CD40LG CD4 ALB
33 sleep apnea 29.6 TNF IL10 ALB
34 autoimmune disease 29.6 TNFSF13B TNF IL10 HLA-DRB1 FOXP3 FCRL3
35 drug allergy 29.6 CD40LG CD4 ALB
36 chronic graft versus host disease 29.6 TNFSF13B IL10 CD4 ALB
37 keratoconjunctivitis sicca 29.6 CD40LG CD4 ALB
38 portal hypertension 29.6 TNF CFTR CD40LG CD4 ALB
39 hashimoto thyroiditis 29.6 TNF IL10 HLA-DRB1 FOXP3 CTLA4
40 proteasome-associated autoinflammatory syndrome 1 29.6 TNF IL10 ALB
41 viral hepatitis 29.5 TNF IL10 HLA-DRB1 CD40LG ALB
42 lupus erythematosus 29.5 TNF IL10 HLA-DRB1 FCRL3 CTLA4 CD40LG
43 endocarditis 29.5 TNF IL10 ALB
44 herpes zoster 29.5 TNF IL10 HLA-DRB1 CD40LG CD4
45 acute cystitis 29.4 TNF IL10 CD40LG CD4 ALB
46 coronary artery anomaly 29.4 TNF IL10 CD40LG CD4 ALB
47 lung disease 29.4 TNF IL10 CFTR CD40LG ALB
48 autoimmune hepatitis 29.4 TNF IL10 HLA-DRB1 FOXP3 CTLA4 CD40LG
49 inflammatory bowel disease 29.4 TNF IL10 HLA-DRB1 FOXP3 ENO1 CTLA4
50 collagen disease 29.3 TNFSF13B TNF IL10 CD40LG CD4

Graphical network of the top 20 diseases related to Autoimmune Pancreatitis:



Diseases related to Autoimmune Pancreatitis
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Symptoms & Phenotypes for Autoimmune Pancreatitis

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MGI Mouse Phenotypes related to Autoimmune Pancreatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 ALB CA2 CD4 CFTR CTLA4 FOXP3
2 endocrine/exocrine gland MP:0005379 9.9 ALB CA2 CD4 CD40LG CFTR CTLA4
3 homeostasis/metabolism MP:0005376 9.77 ALB CA2 CA4 CD4 CD40LG CFTR
4 mortality/aging MP:0010768 9.44 ABCF1 ALB CA2 CA4 CD4 CD40LG
Sources

Drugs & Therapeutics for Autoimmune Pancreatitis

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Drugs for Autoimmune Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3 Antirheumatic Agents Phase 1, Phase 2
4
Lenalidomide Approved Phase 1 191732-72-6 216326
5 Angiogenesis Inhibitors Phase 1
6
Gemcitabine Approved 95058-81-4 60750
7
Pancrelipase Approved, Investigational 53608-75-6
8
Prednisone Approved, Vet_approved 53-03-2 5865
9
Hydrocortisone acetate Approved, Vet_approved 50-03-3
10
Hydrocortisone Approved, Vet_approved 50-23-7 5754
11
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
12
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
13
Calcium Approved, Nutraceutical 7440-70-2 271
14 Liver Extracts
15 Anti-Infective Agents
16 Antiviral Agents
17 Antimetabolites
18 Immunosuppressive Agents
19 pancreatin
20 Immunoglobulin G Early Phase 1
21 Immunoglobulins
22 Antibodies
23 Micronutrients
24 Vitamins
25 Trace Elements
26 Nutrients
27 Ergocalciferols
28 Vitamin D2
29 Calciferol
30 Calcium, Dietary
31 Immunologic Factors
32 Anti-Inflammatory Agents
33 Hydrocortisone hemisuccinate
34 Hydrocortisone-17-butyrate
35 Hydrocortisone 17-butyrate 21-propionate
36 Antibodies, Antinuclear

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
2 Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial Completed NCT02705638 Phase 1 Rituximab;Lenalidomide
3 EUS-guided Procore-biopsy in Diagnosing Autoimmune Pancreatitis Unknown status NCT01774513
4 A Large Sample Follow-up Study of Long-term Complications of Acute Pancreatitis Unknown status NCT02305914
5 Dynamic Changes of the Serum Level of Immunoglobulin G4(IgG4) and Interleukin-10(IL-10) in the Patients of Pancreatic Cancer After Gemcitabine-based Chemotherapy Unknown status NCT02654288
6 Pancreatic Duct Evaluation in Autoimmune Pancreatitis: Intraindividual Comparison of MR Pancreatography at 3.0 T and 1.5 T Completed NCT01773031
7 Clinical Analysis for Predicting of Relapse During Steroid Treatment for Autoimmune Pancreatitis (AIP) in Korean Population Based on the HLA Analysis by Using a High Resolution (Sequence Based) Techniques Completed NCT00444444
8 CT Perfusion of Pancreatic Cancer and Chronic Pancreatitis: Feasibility Study Completed NCT00588367
9 Evaluation of EUS-guided FNA for Diagnosing Autoimmune Pancreatitis: a Prospective, Single-center Study Completed NCT03241797
10 A Randomized Prospective Comparison of the New EUS Guided Acquire TM Needle Biopsy vs EUS Guided Fine Needle Aspiration for Suspected Solid Gastrointestinal Lesions Completed NCT03109639
11 Endoscopic Ultrasound Guided Fine Needle Biopsy With a New Core Histology Needle Versus Conventional Fine Needle Aspiration. Completed NCT01774162
12 A Randomized Trial Comparing a Winged Perimeter Stent and Traditional Polyethylene Plastic Stent in the Management of Malignant Distal Biliary Strictures Completed NCT01514214
13 A Survey of Patients With Elevated Serum IGG4 With Unknown IGG4-related Disease to Whom Biopsy and Performance of Subsequent Specific Staining for Clinical, Laboratory and Pathologic Correlation. Completed NCT02229448
14 A Randomized Trial Comparing a 19-gauge EUS Fine-needle Aspiration Device With a 20-gauge Fine-needle Biopsy Device for the Diagnosis of Autoimmune Pancreatitis Recruiting NCT03753815
15 Evaluation of the FOCUS Diffusion's Added Clinical Value Compared to Conventional MRI With Wide Field View Diffusion in Focal Pancreatic Lesions Characterization Recruiting NCT03961646
16 Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids Active, not recruiting NCT02797665 corticosteroids
17 Assessment of the Different Etiological and Susceptibility Markers in Patients With Pancreatitis: Investigating IG4, Cytomegalovirus, Coxsackie- Virus, Genetic Polymorphism of Vitamin D Receptor Gene Not yet recruiting NCT03830073
18 Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Diagnostic and Prognostic Evaluation of Acute Pancreatitis Not yet recruiting NCT03830060
19 Characterizing IgG4-related Disease With 68Ga-FAPI PET/CT Not yet recruiting NCT04125511 Early Phase 1 68Ga-FAPI
20 Efficacy of Secretin Assisted Dynamic MRCP in the Diagnosis and Follow up of Auto Immune Pancreatitis(AIP) Withdrawn NCT01845467

Search NIH Clinical Center for Autoimmune Pancreatitis

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Genetic Tests for Autoimmune Pancreatitis

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Anatomical Context for Autoimmune Pancreatitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Pancreatitis:

19
Pancreas

MalaCards organs/tissues related to Autoimmune Pancreatitis:

40
Pancreas, Pituitary, Liver, Kidney, T Cells, Salivary Gland, Thyroid
Sources

Publications for Autoimmune Pancreatitis

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Articles related to Autoimmune Pancreatitis:

(show top 50) (show all 2038)
# Title Authors PMID Year
1
Case of IgG4-associated sclerosing cholangitis with normal serum IgG4 concentration, diagnosed by anti-laminin 511-E8 antibody: a novel autoantibody in patients with autoimmune pancreatitis. 61
30760486 2020
2
Diagnosing autoimmune pancreatitis: choosing your weapon. 61
32036944 2020
3
Cardiovascular and Lung Involvement in Patients with Autoimmune Pancreatitis. 61
32028650 2020
4
Insulin secretion improvement during steroid therapy for autoimmune pancreatitis according to the onset of diabetes mellitus. 61
31471733 2020
5
Comparison of a 22-gauge Franseen-tip needle with a 20-gauge forward-bevel needle for the diagnosis of type 1 autoimmune pancreatitis: a prospective, randomized, controlled, multicenter study (COMPAS study). 61
31654634 2020
6
Icicle sign: autoimmune pancreatitis. 61
31712867 2020
7
Activation of interferon regulatory factor 7 in plasmacytoid dendritic cells promotes experimental autoimmune pancreatitis. 61
31960143 2020
8
Time to dissect the autoimmune etiology of cancer antibody immunotherapy. 61
31895048 2020
9
Intense FAPI Uptake in Inflammation May Mask the Tumor Activity of Pancreatic Cancer in 68Ga-FAPI PET/CT. 61
31977474 2020
10
Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis. 61
31902317 2020
11
Genetic analysis of IgG4-related disease. 61
31104539 2020
12
Multilocular Cyst of Type 1 Autoimmune Pancreatitis Masquerading as Cancerization of Intraductal Papillary Mucinous Neoplasm. 61
31484912 2020
13
Japanese Clinical Diagnostic Criteria for Autoimmune Pancreatitis, 2018: Revision of Japanese Clinical Diagnostic Criteria for Autoimmune Pancreatitis, 2011. 61
31856100 2020
14
Can the wet suction technique change the efficacy of endoscopic ultrasound-guided fine-needle aspiration for diagnosing autoimmune pancreatitis type 1? A prospective single-arm study. 61
31970173 2020
15
Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016. 61
31872350 2019
16
Early pancreatic cancer in IgG4-related pancreatic mass: A case report. 61
31879536 2019
17
A Case of IgG4-related Sclerosing Cholangitis Mimicking Cholangiocarcinoma Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration. 61
31875638 2019
18
IgG4-Related Sclerosing Cholangitis: A Clinical and Imaging Review. 61
31509439 2019
19
Steroid Therapy and Steroid Response in Autoimmune Pancreatitis. 61
31905944 2019
20
Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature. 61
31366800 2019
21
Dramatic Improvement of Glycemic Control by Promptly Starting Steroid Therapy at an Early Stage of Autoimmune Pancreatitis in a Subject with Type 2 Diabetes. 61
31366799 2019
22
Autoimmune pancreatitis not otherwise specified (NOS): Clinical features and outcomes of the forgotten type. 61
31248720 2019
23
The multifaceted nature of diabetes mellitus induced by checkpoint inhibitors. 61
31423559 2019
24
Orbital IgG4 Disease: Imaging Findings on 68Ga-DOTANOC PET/CT. 61
31867079 2019
25
Review of IgG4-related disease. 61
31722794 2019
26
Autoimmune pancreatitis in a child: a challenging diagnosis. 61
31722878 2019
27
Immunoglobulin G4 (IgG4)-related disease of the stomach - a challenging differential diagnosis in suspected gastric cancer. 61
31739375 2019
28
Untypical autoimmune pancreatitis and pancreatic cancer: differential diagnosis experiences extracted from misdiagnose of two cases. 61
31699117 2019
29
Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer. 61
31744269 2019
30
[Autoimmune pancreatitis]. 61
31791461 2019
31
Chronic Pancreatitis or Pancreatic Tumor? A Problem-solving Approach. 61
31584860 2019
32
Pancreatic lymphoma: A cytologic diagnosis challenge. 61
31774250 2019
33
A case report of IgG4-related disease: an insidious path to the diagnosis through kidney, heart and brain. 61
31752722 2019
34
Pancreatic exocrine insufficiency and Crohn's disease. 61
31760738 2019
35
Validity and safety of endoscopic biliary stenting for biliary stricture associated with IgG4-related pancreatobiliary disease during steroid therapy. 61
31673612 2019
36
Intestinal dysbiosis mediates experimental autoimmune pancreatitis via activation of plasmacytoid dendritic cells. 61
31287532 2019
37
Pancreaticobiliary involvement in treated type 1 autoimmune pancreatitis: Imaging pattern and risk factors for disease relapse. 61
31550640 2019
38
Differentiating focal autoimmune pancreatitis and pancreatic ductal adenocarcinoma: contrast-enhanced MRI with special emphasis on the arterial phase. 61
31028441 2019
39
Autoimmune pancreatitis: an update. 61
31650376 2019
40
Radiomics analysis for the differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma in 18 F-FDG PET/CT. 61
31348535 2019
41
Feasibility and usefulness of endoscopic ultrasonography-guided shear-wave measurement for assessment of autoimmune pancreatitis activity: a prospective exploratory study. 61
30993580 2019
42
[Differentiation of autoimmune pancreatitis and pancreatic ductal adenocarcinoma based on multi-modality texture features in 18F-FDG PET/CT]. 61
31631623 2019
43
Risk factors and treatment of relapses in autoimmune pancreatitis: Rituximab is safe and effective. 61
31662864 2019
44
A feasible CT feature to differentiate focal-type autoimmune pancreatitis from pancreatic ductal adenocarcinoma. 61
31469256 2019
45
[A Case of Laparoscopic Resection of Cecal Carcinoma Complicated with IgG4-Related Disease]. 61
31631170 2019
46
Autoimmune pancreatitis masquerading as carcinoma head of pancreas: A case report and review of literature. 61
31440370 2019
47
Differentiation of focal autoimmune pancreatitis from pancreatic ductal adenocarcinoma. 61
31493022 2019
48
Diffuse Pancreatic Cancer Mimicking Autoimmune Pancreatitis. 61
31178502 2019
49
IgG4-Producing MALT Lymphoma in the Renal Hilum. 61
31911772 2019
50
IgG4 Related Autoimmune Pancreatitis: An Overview and the Emerging Role of Serum Eotaxin as a Potential Treatment Target. 61
31542909 2019
Sources

Variations for Autoimmune Pancreatitis

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Cosmic variations for Autoimmune Pancreatitis:

9 (show all 23)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM100290763 NFE2L2 kidney,NS,carcinoma,Type 2 c.245A>G p.E82G 2:177234072-177234072 3
2 COSM88843775 MET kidney,NS,carcinoma,Type 1 c.3803T>C p.M1268T 7:116783420-116783420 3
3 COSM88850571 MET kidney,NS,carcinoma,Type 1 c.3637C>T p.L1213F 7:116782048-116782048 3
4 COSM88845447 MET kidney,NS,carcinoma,Type 1 c.3742T>C p.Y1248H 7:116783359-116783359 3
5 COSM88854098 MET kidney,NS,carcinoma,Type 1 c.3538C>T p.H1180Y 7:116778919-116778919 3
6 COSM88844618 MET kidney,NS,carcinoma,Type 1 c.3328G>A p.V1110I 7:116777403-116777403 3
7 COSM88846612 MET kidney,NS,carcinoma,Type 1 c.3476C>G p.S1159W 7:116778857-116778857 3
8 COSM88857375 MET kidney,NS,carcinoma,Type 1 c.3446T>C p.M1149T 7:116778827-116778827 3
9 COSM88849805 MET kidney,NS,carcinoma,Type 1 c.3637C>A p.L1213I 7:116782048-116782048 3
10 COSM88848019 MET kidney,NS,carcinoma,Type 1 c.3616G>T p.V1206L 7:116782027-116782027 3
11 COSM102553435 kidney,NS,carcinoma,Type 1 c.3749T>C p.M1250T 7:116783420-116783420 3
12 COSM102557035 kidney,NS,carcinoma,Type 1 c.3422C>G p.S1141W 7:116778857-116778857 3
13 COSM114951681 kidney,NS,carcinoma,Type 2 c.197A>G p.E66G 2:177234072-177234072 3
14 COSM100298136 kidney,NS,carcinoma,Type 2 c.197A>G p.E66G 2:177234072-177234072 3
15 COSM106501511 kidney,NS,carcinoma,Type 2 c.197A>G p.E66G 2:177234072-177234072 3
16 COSM102558765 kidney,NS,carcinoma,Type 1 c.3562G>T p.V1188L 7:116782027-116782027 3
17 COSM112705743 kidney,NS,carcinoma,Type 2 c.197A>G p.E66G 2:177234072-177234072 3
18 COSM102555469 kidney,NS,carcinoma,Type 1 c.3688T>C p.Y1230H 7:116783359-116783359 3
19 COSM102561867 kidney,NS,carcinoma,Type 1 c.3583C>T p.L1195F 7:116782048-116782048 3
20 COSM102554703 kidney,NS,carcinoma,Type 1 c.3274G>A p.V1092I 7:116777403-116777403 3
21 COSM102566238 kidney,NS,carcinoma,Type 1 c.3484C>T p.H1162Y 7:116778919-116778919 3
22 COSM102569465 kidney,NS,carcinoma,Type 1 c.3392T>C p.M1131T 7:116778827-116778827 3
23 COSM102560896 kidney,NS,carcinoma,Type 1 c.3583C>A p.L1195I 7:116782048-116782048 3
Sources

Expression for Autoimmune Pancreatitis

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Search GEO for disease gene expression data for Autoimmune Pancreatitis.
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Pathways for Autoimmune Pancreatitis

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Pathways related to Autoimmune Pancreatitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.25 TNFSF13B TNF IL10 HRAS HLA-DRB1 CD40LG
2
Immune response NFAT in immune response 22
Show member pathways
 12.44 TNF IL10 HRAS HLA-DRB1 CD40LG CD4
3
Th17 cell differentiation 36
Show member pathways
 12.43 TNF IL10 HLA-DRB1 FOXP3 CD4
4
T cell receptor signaling pathway 36
Show member pathways
 12.34 TNF IL10 HRAS CTLA4 CD40LG CD4
5
ICos-ICosL Pathway in T-Helper Cell 63
Show member pathways
 12.27 HLA-DRB1 CTLA4 CD40LG CD4
6
NF-kappaB Signaling 4
12.25 TNFSF13B TNF IL10 FOXP3 CTLA4 CD40LG
7
Human T-cell leukemia virus 1 infection 36
12.19 TNF HRAS HLA-DRB1 CD4
8
Toxoplasmosis 36
Show member pathways
 12.11 TNF IL10 HLA-DRB1 CD40LG
9
Allograft rejection 1 36
Show member pathways
 11.97 TNFSF13B TNF IL10 HLA-DRB1 FOXP3 CTLA4
10
Cell adhesion molecules (CAMs) 36
11.95 HLA-DRB1 CTLA4 CD40LG CD4
11
Pancreatic secretion 36
11.77 PRSS1 CFTR CA2 AMY2A
12
Rheumatoid arthritis 36
11.7 TNFSF13B TNF HLA-DRB1 CTLA4
13
Innate Lymphoid Cell Differentiation Pathways 64
11.67 TNF IL10 CD4
14
Dendritic Cells Developmental Lineage Pathway 64
11.62 TNF IL10 CD4
15
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway 22
Show member pathways
 11.61 TNFSF13B TNF CD40LG
16
CTLA4 Signaling 63
11.59 HLA-DRB1 CTLA4 CD4
17
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.55 TNF FOXP3 CTLA4 CD40LG
18
Malaria 36
11.4 TNF IL10 CD40LG
19
Th2 Differentiation Pathway 64
11.35 IL10 FOXP3 CD4
20
B Cell Development Pathways 64
11.18 IL10 FCRL3 CD40LG CD4
21
Cytokines and Inflammatory Response 1
10.72 TNF IL10 HLA-DRB1 CD4
Sources

GO Terms for Autoimmune Pancreatitis

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Cellular components related to Autoimmune Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 TNFSF13B TNF KCNA3 HRAS HLA-DRB1 FCRL3
2 extracellular space GO:0005615 9.61 TNFSF13B TNF PRSS1 IL10 ENO1 CD40LG
3 external side of plasma membrane GO:0009897 9.55 TNF HLA-DRB1 CTLA4 CD40LG CD4
4 cell surface GO:0009986 9.23 TNF HLA-DRB1 FCRL3 ENO1 CFTR CD40LG

Biological processes related to Autoimmune Pancreatitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.69 TNFSF13B CD40LG CD4
2 T cell costimulation GO:0031295 9.65 TNFSF13B CTLA4 CD40LG
3 bicarbonate transport GO:0015701 9.58 CFTR CA4 CA2
4 T cell receptor signaling pathway GO:0050852 9.55 HRAS HLA-DRB1 FOXP3 CTLA4 CD4
5 T-helper 1 type immune response GO:0042088 9.54 HRAS HLA-DRB1
6 negative regulation of interleukin-6 production GO:0032715 9.54 TNF IL10 FOXP3
7 endothelial cell apoptotic process GO:0072577 9.52 TNF IL10
8 immune response GO:0006955 9.5 TNFSF13B TNF IL10 HLA-DRB1 CTLA4 CD40LG
9 negative regulation of cytokine secretion involved in immune response GO:0002740 9.49 TNF IL10
10 regulation of immunoglobulin secretion GO:0051023 9.46 TNF CD40LG
11 immunoglobulin secretion GO:0048305 9.43 TNFSF13B CD40LG
12 negative regulation of interferon-gamma production GO:0032689 9.43 IL10 HLA-DRB1 FOXP3
13 receptor biosynthetic process GO:0032800 9.32 TNF IL10
14 negative regulation of T cell proliferation GO:0042130 8.92 IL10 HLA-DRB1 FOXP3 CTLA4

Molecular functions related to Autoimmune Pancreatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNFSF13B TNF IL10 CD40LG
2 tumor necrosis factor receptor binding GO:0005164 8.8 TNFSF13B TNF CD40LG
Sources

Sources for Autoimmune Pancreatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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