Autoimmune Pancreatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ A rare pancreatic disease characterized by chronic non-alcoholic pancreatitis that presents with abdominal pain, steatorrhea, obstructive jaundice and responds well to steroid therapy and is seen in two subforms: type which affects elderly males, involves other organs and has increased immunoglobin G4 (IgG4) levels and type 2 which affects both sexes equally but presents at a younger age and has no other organ involvement or increased IgG4 levels.

MalaCards based summary: Autoimmune Pancreatitis, also known as lymphoplasmocytic sclerosing pancreatitis, is related to igg4-related disease and pancreatitis, hereditary. An important gene associated with Autoimmune Pancreatitis is IL33 (Interleukin 33), and among its related pathways/superpathways are Extrafollicular B cell activation by SARS-CoV-2 and Innate Lymphoid Cells Differentiation. The drugs Rituximab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone and liver, and related phenotypes are homeostasis/metabolism and immune system

GARD: ¹⁹ Autoimmune pancreatitis affects the pancreas, a gland behind the stomach and in front of the spine, and can also affect the bile ducts, salivary glands, kidneys, and lymph nodes. It is thought to occur when the immune system mistakenly begins to attack these healthy body tissues, glands, and organs. Common signs and symptoms include painless jaundice, weight loss, and noncancerous masses in the pancreas and other organs.

Disease Ontology: ¹¹ An autoimmune disease of endocrine system that is located in the pancreas.

Wikipedia: ⁷⁵ Autoimmune Pancreatitis (AIP) is an increasingly recognized type of chronic pancreatitis that can be... more...

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Related Diseases for Autoimmune Pancreatitis

Diseases in the Pancreatitis family:

Pancreatitis, Hereditary	Autoimmune Pancreatitis
Acute Pancreatitis	Prss1-Related Hereditary Pancreatitis
Autoimmune Pancreatitis Type 2	Autoimmune Pancreatitis Type 1

Diseases related to Autoimmune Pancreatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 814)

#	Related Disease	Score	Top Affiliating Genes
1	igg4-related disease	31.6	IL10 ICOSLG CRP CD4 CCR6 CA2
2	pancreatitis, hereditary	31.6	SPINK1 SCT PRSS1 CFTR
3	sialadenitis	31.3	ICOSLG CD4 CCR6
4	mikulicz disease	31.3	SPINK1 IL10 ICOSLG CRP CD4 CCR6
5	sclerosing cholangitis	31.1	IL10 ICOSLG CRP CD4 CCR6
6	pancreatitis	31.0	SPINK1 SCT PRSS1 MIR21 IL10 CRP
7	sjogren syndrome	30.8	IL10 ICOSLG CCR6 CA2
8	cholangitis	30.7	IL10 ENPP2 CRP CFTR CEACAM5 CA2
9	autoimmune disease	30.6	IL10 IFNA1 ICOSLG FCRL3 CRP CCR6
10	autoimmune cholangitis	30.6	CD4 CCR6 CA2
11	bowel dysfunction	30.6	IL10 CRP CFTR
12	thrombocytopenic purpura, autoimmune	30.5	ICOSLG CD4 CCR6
13	optic papillitis	30.5	CRP CD4
14	thyroiditis	30.5	IL10 IFNA1 CRP
15	acute pancreatitis	30.5	SPINK1 SCT PRSS1 IL10 CRP CFTR
16	interstitial nephritis	30.4	ICOSLG CRP CD4 CCR6
17	thrombocytopenia due to platelet alloimmunization	30.4	IL10 ICOSLG CD4 CCR6
18	alcoholic pancreatitis	30.4	SPINK1 SCT PRSS58 PRSS1 CFTR
19	autoimmune polyendocrine syndrome	30.3	IFNA1 ICOSLG CD4 CCR6
20	dacryoadenitis	30.3	IL10 ICOSLG CD4 CCR6
21	cholangitis, primary sclerosing	30.2	SCT IL10 ICOSLG CRP CFTR CEACAM5
22	henoch-schoenlein purpura	30.2	ICOSLG CRP CD4 CCR6
23	keratoconjunctivitis sicca	30.1	ICOSLG CD4 CCR6
24	alcohol use disorder	30.0	CRP CD4 CCR6
25	colitis	30.0	MIR21 IL10 ICOSLG CRP CD4 CCR6
26	prss1-related hereditary pancreatitis	30.0	SPINK1 PRSS1 CFTR
27	castleman disease	30.0	IL10 CRP CD4 CCR6
28	lipid metabolism disorder	30.0	MIR21 IL10 CRP CCR6
29	gallbladder disease	30.0	CRP CFTR CEACAM5 CCR6
30	arteries, anomalies of	30.0	MIR21 ICOSLG CRP CCR6
31	interstitial lung disease	29.9	MIR21 IL10 ICOSLG CRP CCR6
32	herpes zoster	29.9	IL10 IFNA1 CD4 CCR6
33	anemia, autoimmune hemolytic	29.9	IL10 ICOSLG CRP CD4 CCR6
34	aortitis	29.9	CRP CD4 CCR6
35	lymphatic system disease	29.9	MIR21 ICOSLG CD4 CCR6
36	crohn's disease	29.9	MIR21 IL10 ICOSLG CRP CD4 CCR6
37	exocrine pancreatic insufficiency	29.9	SPINK1 SCT PRSS1 CFTR CELA3B CELA1
38	sarcoidosis 1	29.8	IL10 ICOSLG CRP CD4 CCR6
39	allergic disease	29.8	MIR21 IL33 IL10 ICOSLG CD4 CCR6
40	aortic aneurysm, familial abdominal, 1	29.8	MIR21 IL10 CRP CCR6
41	hypersensitivity vasculitis	29.8	ICOSLG CRP CD4 CCR6
42	ileitis	29.8	IL10 CD4 CCR6
43	bile duct adenocarcinoma	29.8	MIR21 ICOSLG CEACAM5 CCR6
44	pancreatic cancer	29.8	SPINK1 SCT PRSS1 MIR21 IL10 ICOSLG
45	nutritional deficiency disease	29.8	SCT CRP CCR6
46	adult respiratory distress syndrome	29.8	MIR21 IL10 CRP CCR6
47	lung disease	29.7	MIR21 IL10 CFTR CEACAM5 CCR6
48	leukemia, acute myeloid	29.7	MIR21 IL10 IFNA1 ICOSLG CD4 CCR6
49	t cell deficiency	29.7	IL10 ICOSLG CD4 CCR6
50	vogt-koyanagi-harada disease	29.7	IL10 ICOSLG CD4 CCR6

Graphical network of the top 20 diseases related to Autoimmune Pancreatitis:

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Symptoms & Phenotypes for Autoimmune Pancreatitis

MGI Mouse Phenotypes related to Autoimmune Pancreatitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.8	CA2 CCR6 CD4 CEACAM5 CFTR CRP
2	immune system	MP:0005387	9.4	CA2 CCR6 CD4 CEACAM5 CFTR CRP

Sources

Drugs & Therapeutics for Autoimmune Pancreatitis

Drugs for Autoimmune Pancreatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Rituximab

Approved

Phase 1, Phase 2

174722-31-7

2

Antirheumatic Agents

Phase 1, Phase 2

3

Antineoplastic Agents, Immunological

Phase 1, Phase 2

4

Immunologic Factors

Phase 1, Phase 2

5

Lenalidomide

Approved

Phase 1

191732-72-6

216326

6

Angiogenesis Inhibitors

Phase 1

7

Prednisone

Approved, Vet_approved

53-03-2

5865

Synonyms:

1,2-Dehydrocortisone

1,4-Pregnadiene-17a,21-diol-3,11,20-trione

1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione

1,4-Pregnadiene-17α,21-diol-3,11,20-trione

17,21-Dihydroxypregna-1,4-diene-3,11,20-trione

Acis brand OF prednisone

Acsis, prednison

Adasone

Ancortone

Apo-prednisone

Apotex brand OF prednisone

Aventis brand OF prednisone

Betapar

Bicortone

Cartancyl

Colisone

Cortan

Cortancyl

Cortidelt

Cotone

Cutason

Dacorten

Dacortin

Decortancyl

Decortin

Decortisyl

Dehydrocortisone

Dekortin

Delcortin

Dellacort

Dellacort A

Delta Cortelan

Delta E

Delta-cortelan

Deltacortene

delta-Cortisone

Deltacortisone

Deltacortone

Delta-cortone

DELTA-DOME

Deltasone

Deltison

Deltisona

Deltisone

Deltra

Diadreson

Di-Adreson

Diba brand OF prednisone

Econosone

Encorton

Encortone

Enkortolon

Enkorton

Fawns and mcallan brand OF prednisone

FERNISONE

Ferring brand OF prednisone

Fiasone

GALENpharma brand OF prednisone

Halsey drug brand OF prednisone

Hexal brand OF prednisone

Hoechst brand OF prednisone

Hostacortin

ICN brand OF prednisone

Incocortyl

In-Sone

Juvason

Kortancyl

Lichtenstein brand OF prednisone

Liquid pred

Lisacort

LODOTRA

Lodotra®|Sterapred®

Me-Korti

Merck brand OF prednisone

Merz brand OF prednisone

Metacortandracin

Meticorten

Mibe brand OF prednisone

Nisona

Nizon

Novoprednisone

NSC-10023

Nurison

Orasone

Origen Prednisone

Panafcort

Panasol

PARACORT

Parmenison

Pehacort

Pharmacia brand OF prednisone

PRD

Precort

Predeltin

PREDN

Predni tablinen

PREDNICEN-M

Prednicorm

Prednicort

Prednicot

Prednidib

Prednilonga

Predniment

Prednison

Prednison acsis

Prednison galen

Prednison hexal

Prednisona

Prednisona [INN-Spanish]

Prednisone

PREDNISONE INTENSOL

PREDNISONE TABLETS

Prednisonum

Prednisonum [INN-Latin]

Prednitone

Prednizon

Prednovister

Presone

Pronison

Pronisone

RAYOS

Rectodelt

Retrocortine

Schering-plough brand OF prednisone

Seatrace brand OF prednisone

SERVISONE

Solvay brand OF prednisone

Sone

Sterapred

Supercortil

Trommsdorff brand OF prednisone

Ultracorten

Ultracortene

Winpred

Wojtab

Zenadrid

8

Ethanol

Approved

64-17-5

702

Synonyms:

[CH2Me(OH)]

[OEtH]

1-Hydroxyethane

ABLYSINOL

Absolute alcohol

Absolute ethanol

Absolute ethyl alcohol

Aethanol

Aethylalkohol

Alcare hand degermer

Alcohol

Alcohol (ethyl)

Alcohol anhydrous

Alcohol denatured

ALCOHOL DETERMINATION--ALCOHOL

Alcohol etilico

Alcohol etílico

Alcohol, absolute

Alcohol, Dehydrated

Alcohol, denatured

ALCOHOL, DILUTED

Alcohol, ethyl

Alcohol, grain

ALCOHOL, RUBBING

Alcohols

Alcool ethylique

Alcool éthylique

Alcool etilico

Algrain

Alkohol

Alkoholu etylowego

Aminoethanol

Anhydrol

Anhydrous alcohol

Anhydrous ethanol

Äthanol

Äthylalkohol

B3324

Beta-Aminoethanol

Beta-Aminoethyl Alcohol

Beta-Ethanolamine

Beta-Hydroxyethylamine

C2H5OH

Caswell No. 426

Colamine

Cologne spirit

Cologne spirits

Dehydrated alcohol

Dehydrated ethanol

Denatured alcohol

Denatured Alcohol Cd-10

Denatured Alcohol Cd-5

Denatured Alcohol Cd-5a

Denatured Alcohol Sd-1

Denatured Alcohol Sd-13a

Denatured Alcohol Sd-17

Denatured Alcohol Sd-23a

Denatured Alcohol Sd-28

Denatured Alcohol Sd-30

Denatured Alcohol Sd-39b

Denatured Alcohol Sd-39c

Denatured Alcohol Sd-3a

Denatured Alcohol Sd-40m

Denatured ethanol

Desinfektol el

Diluted alcohol

Distilled spirits

DRINKING ALCOHOL

E1510

Envision Conditioner Pdd 9020

ETA

Etanol

Etanolo

ETHANOL

éthanol

Ethanol 200 proof

Ethanol Absolute

Ethanol Absolute Bp

Ethanol Anhydrous

Ethanol Extra Pure

Ethanol solution

Ethanol, Silent Spirit

Ethicap

Ethyl alc

Ethyl alcohol

Ethyl Alcohol & Water, 10%

Ethyl Alcohol & Water, 20%

Ethyl Alcohol & Water, 30%

Ethyl Alcohol & Water, 40%

Ethyl Alcohol & Water, 5%

Ethyl Alcohol & Water, 50%

Ethyl Alcohol & Water, 60%

Ethyl Alcohol & Water, 70%

Ethyl Alcohol & Water, 80%

Ethyl Alcohol & Water, 95%

Ethyl Alcohol & Water, 96%

Ethyl alcohol anhydrous

Ethyl alcohol in alcoholic beverages

Ethyl alcohol usp

Ethyl Alcohol, Anhydrous

Ethyl Alcohol, Denatured

Ethyl hydrate

Ethyl hydroxide

Ethylol

Ethylolamine

EtOH

FEMA NO. 2419

Fermentation alcohol

Glycinol

Grain alcohol

Hinetoless

HSDB 531

Hydroxyethane

Infinity pure

Jaysol

Jaysol S

Lux

METHYLATED MINERAL

Methylated Spirit Mineralised

Methylcarbinol

Molasses alcohol

NCI-C03134

NSC-85228

PM-6193-200

Potato alcohol

Punctilious ethyl alcohol

Pyro

Reagent Alcohol

Silent spirit

SPIRIGEL

Spirit

Spirits OF wine

Spiritus vini

Spirt

SURG

Synasol

Tecsol

Tecsol C

Thanol

Thiofaco M-50

Undenatured ethanol

USAF EK-1597

VODKA

9

Pancrelipase

Approved, Investigational

53608-75-6

8519

10

Immunoglobulins, Intravenous

11

Immunoglobulins

12

Immunoglobulin G

13

Antibodies

14

Liver Extracts

15

Gastrointestinal Agents

16

Pancreatin

Interventional clinical trials:

(show all 17)

#	Name	Status	NCT ID	Phase	Drugs
1	Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial	Completed	NCT01584388	Phase 1, Phase 2	Rituximab
2	Evaluation of a New EUS Guided Biopsy Needle (SharkCore) Comparing to Standard EUS Needle (ProCore): A Prospective Randomized, Controlled Multicenter Study	Withdrawn	NCT02766842	Phase 2
3	Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial	Completed	NCT02705638	Phase 1	Rituximab;Lenalidomide
4	Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids	Unknown status	NCT02797665		corticosteroids
5	EUS-guided Procore-biopsy in Diagnosing Autoimmune Pancreatitis	Unknown status	NCT01774513
6	Clinical Analysis for Predicting of Relapse During Steroid Treatment for Autoimmune Pancreatitis (AIP) in Korean Population Based on the HLA Analysis by Using a High Resolution (Sequence Based) Techniques	Completed	NCT00444444
7	Evaluation of EUS-guided FNA for Diagnosing Autoimmune Pancreatitis: a Prospective, Single-center Study	Completed	NCT03241797
8	Pancreatic Duct Evaluation in Autoimmune Pancreatitis: Intraindividual Comparison of MR Pancreatography at 3.0 T and 1.5 T	Completed	NCT01773031
9	A Real-world Comparison of FNB and FNA in IHC-required Lesions: A Prospective, Multicenter Study.	Completed	NCT05565066
10	CT Perfusion of Pancreatic Cancer and Chronic Pancreatitis: Feasibility Study	Completed	NCT00588367
11	A Randomized Trial Comparing a 19-gauge EUS Fine-needle Aspiration Device With a 20-gauge Fine-needle Biopsy Device for the Diagnosis of Autoimmune Pancreatitis	Recruiting	NCT03753815
12	Role of Endoscopic Ultrasound-guided Fine-needle Biopsy in the Diagnosis of Autoimmune Pancreatitis	Recruiting	NCT04397731
13	Construction and Validation of a Diagnosis Model Based on Endoscopic Ultrasound Characteristics for Differentiating Between Focal Autoimmune Pancreatitis and Pancreatic Cancer	Recruiting	NCT04834505
14	Study on Microflora Characteristics of Pancreatic Solid Lesions Via Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy	Recruiting	NCT05171517
15	Endoscopic Ultrasound Shear Wave for Neoplasia and Inflammation Assessment Among Solid Pancreas Lesions: a Case-control Observational Trial.	Active, not recruiting	NCT05095831
16	Utilization of Artificial Intelligence for the Development of an EUS-convolution Neural Network Model Trained to Differentiate Pancreatic Cancer From Other Pancreatic Solid Lesions	Not yet recruiting	NCT05476978
17	Efficacy of Secretin Assisted Dynamic MRCP in the Diagnosis and Follow up of Auto Immune Pancreatitis(AIP)	Withdrawn	NCT01845467

Search NIH Clinical Center for Autoimmune Pancreatitis

Cochrane evidence based reviews: autoimmune pancreatitis

Sources

Genetic Tests for Autoimmune Pancreatitis

Sources

Anatomical Context for Autoimmune Pancreatitis

Organs/tissues related to Autoimmune Pancreatitis:

FMA: Pancreas

MalaCards : Pancreas, Bone, Liver, T Cells, Salivary Gland, Lung, Kidney

Sources

Publications for Autoimmune Pancreatitis

Articles related to Autoimmune Pancreatitis:

(show top 50) (show all 2404)

#	Title	Authors	PMID	Year
1	Radiomics based on diffusion-weighted imaging for differentiation between focal-type autoimmune pancreatitis and pancreatic carcinoma. ⁶²	Shiraishi M...Ojiri H	35946923	2022
2	High-fat diet aggravates experimental autoimmune pancreatitis through the activation of type I interferon signaling pathways. ⁶²	Sekai I...Watanabe T	36403482	2022
3	The role of serological biomarkers in the diagnosis and management of autoimmune pancreatitis. ⁶²	de Pretis N...Frulloni L	36125384	2022
4	Correction to: The effect of CT texture‑based analysis using machine learning approaches on radiologists' performance in differentiating focal‑type autoimmune pancreatitis and pancreatic duct carcinoma. ⁶²	Anai K...Korogi Y	35809211	2022
5	Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report. ⁶²	Sato R...Kato H	36387831	2022
6	Eosinophilic pancreatitis with serum IgG4-positivity, potentially associated with autoimmune pancreatitis. ⁶²	Takeda S...Muramatsu A	36385250	2022
7	The application of high-throughput proteomics in cytopathology. ⁶²	Nikas IP...Ryu HS	36345621	2022
8	The effect of CT texture-based analysis using machine learning approaches on radiologists' performance in differentiating focal-type autoimmune pancreatitis and pancreatic duct carcinoma. ⁶²	Anai K...Korogi Y	35727458	2022
9	Steroid treatment response combined with serological mark in differentiating type-1 autoimmune pancreatitis from pancreatic cancer. ⁶²	Liu B...Liu B	36397434	2022
10	A multidomain fusion model of radiomics and deep learning to discriminate between PDAC and AIP based on 18F-FDG PET/CT images. ⁶²	Wei W...Zuo C	36409398	2022
11	An adult female case of autoimmune pancreatitis with gastric outlet obstruction complicated by annular pancreas. ⁶²	Asahara K...Shirane N	36333486	2022
12	Autoimmune Pancreatitis with Massive Ascites and Multiple Pancreatic Cysts Successfully Treated with Prednisolone: A Case Report. ⁶²	Kido K...Nakagawa H	36198587	2022
13	Systematic review and meta-analysis of MRI features for differentiating autoimmune pancreatitis from pancreatic adenocarcinoma. ⁶²	Yoon SB...Kim MH	35486167	2022
14	Fighting Fire with Fire: Exosomes and Acute Pancreatitis-Associated Acute Lung Injury. ⁶²	Yang Q...Chen H	36354526	2022
15	Evaluating the role of endoscopic ultrasound in pancreatitis. ⁶²	Rana SS	36263489	2022
16	Diagnostic Utility of Serum IgG4 in Autoimmune Pancreatitis: An Updated Comprehensive Systematic Review and Meta-analysis. ⁶²	Lee SC...Yu KH	34516462	2022
17	Utility of Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Biopsy for Histological Diagnosis of Type 2 Autoimmune Pancreatitis. ⁶²	Hayashi H...Masamune A	36292153	2022
18	Role of apoptosis inhibitor of macrophages in patients with IgG4‑related disease/autoimmune pancreatitis and the clinical characteristics associated with this condition. ⁶²	Tanoue S...Ido A	36158321	2022
19	Hypertrophic Perianal Herpes Mimicking Squamous Cell Cancer: A Case Report and a Review of the Literature. ⁶²	Singh S...Gupta R	36439566	2022
20	Autoimmune Pancreatitis Secondary to Immune Checkpoint Inhibitor Therapy (Type 3 AIP): Insights Into a New Disease From Serial Pancreatic Imaging. ⁶²	Thomas AS...Chari ST	36220459	2022
21	Current status of type 1 (IgG4-related) autoimmune pancreatitis. ⁶²	Uchida K...Okazaki K	35916965	2022
22	Diffuse Involvement of Pancreas is not Always Autoimmune Pancreatitis. ⁶²	He M...Xue H	35279380	2022
23	Autoimmune Pancreatitis: From Pathogenesis to Treatment. ⁶²	Nista EC...Candelli M	36293522	2022
24	Correlation of Autoimmune Pancreatitis and Risk of Gastric Cancer in East Asian Population. ⁶²	Liu K...Zhou Y	35435857	2022
25	Acute liver injury and IgG4-related autoimmune pancreatitis following mRNA-based COVID-19 vaccination. ⁶²	Patel AH...Lalos AT	36177105	2022
26	Type 3 autoimmune pancreatitis (immune checkpoint inhibitor-induced pancreatitis). ⁶²	Sayed Ahmed A...Chari ST	35881977	2022
27	Disruption of the intestinal barrier exacerbates experimental autoimmune pancreatitis by promoting the translocation of Staphylococcus sciuri into the pancreas. ⁶²	Yoshikawa T...Watanabe T	36044992	2022
28	Report of Two Cases of Pediatric IgG4-Related Lymphadenopathy (IgG4-LAD): IgG4-Related Disease (IgG4-RD) or a Distinct Clinical Pathological Entity? ⁶²	Meli M...Di Cataldo A	36291407	2022
29	Application of Lip Biopsy for the Histological Diagnosis of Immunoglobulin G4-Related Disease. ⁶²	Tachibana T...Sato Y	33147065	2022
30	Black pleural effusion caused by a pancreaticopleural fistula associated with autoimmune pancreatitis: A case report. ⁶²	Miyadera K...Hirose T	36086788	2022
31	Autoimmune Pancreatitis and Immunoglobulin G4-related Sclerosing Cholangitis: Past, Present, and Future. ⁶²	Moon SH...Kim MH	36156034	2022
32	Navigating the Challenges Associated With a Diagnosis of Autoimmune Pancreatitis and IgG4-Related Sclerosing Cholangitis. ⁶²	Yilmaz O...Deshpande V	36136300	2022
33	Artificial intelligence using deep learning analysis of endoscopic ultrasonography images for the differential diagnosis of pancreatic masses. ⁶²	Kuwahara T...Shimizu Y	35688454	2022
34	Spontaneous remission of autoimmune pancreatitis: Four case reports. ⁶²	Zhang BB...Jin EH	36159515	2022
35	Factors affecting glycemic control in diabetes mellitus complicated by autoimmune pancreatitis. ⁶²	Harai N...Mori Y	35290718	2022
36	Type 2 autoimmune pancreatitis associated with severe ulcerative colitis: Three case reports. ⁶²	Ghali M...Ghaly S	36157795	2022
37	Steroid therapy has an acceptable role as the initial treatment in autoimmune pancreatitis patients with pancreatic cyst formation: Based on a Japanese nationwide study. ⁶²	Kubota K...Collaborators	35950952	2022
38	Autoimmune pancreatitis: can we truly recognize it? Usefulness of contrast-enhanced ultrasonography in two different cases. ⁶²	Bandini G...Accogli E	35802532	2022
39	Prevalence and clinical features of patients with autoimmune pancreatitis and inflammatory bowel disease: A systematic review and meta-analysis. ⁶²	Fukuda S...Tsuchiya K	35596263	2022
40	A systematic review of radiomics in pancreatitis: applying the evidence level rating tool for promoting clinical transferability. ⁶²	Zhong J...Yao W	35986798	2022
41	Autoimmune pancreatitis in pediatrics, a rare disease. ⁶²	Pena-Velez R...Gil-Vargas M	35810097	2022
42	Increased IgG-4 levels in a patient with autism spectrum disorder complicated by autoimmune pancreatitis. ⁶²	Tsou HL...Yeh YW	35468478	2022
43	Author's reply: "ADC values from diffusion-weighted imaging may be lower for autoimmune pancreatitis than for pancreatic ductal adenocarcinoma". ⁶²	Ha J...Choi SH	35614006	2022
44	ADC values from diffusion-weighted imaging may be lower for autoimmune pancreatitis than for pancreatic ductal adenocarcinoma. ⁶²	Moon SH...Jeon TY	35487851	2022
45	Hypercalcemia in IgG4-related disease: coincidental or associated? Case based review. ⁶²	Uskudar Cansu D...Korkmaz C	34994813	2022
46	Correlation of Autoimmune Pancreatitis and Malignancy: Systematic Review and Meta-Analysis. ⁶²	Haghbin H...Aziz M	34297267	2022
47	Complemental Diagnosis of IgG4-Related Pancreaticobiliary Diseases by Multiple Hypoechoic Lesions in the Submandibular Glands. ⁶²	Shimamura N...Enomoto N	35887953	2022
48	Comparison of the diagnostic efficacy of 68 Ga-FAPI-04 PET/MR and 18F-FDG PET/CT in patients with pancreatic cancer. ⁶²	Zhang Z...Zuo C	35243518	2022
49	Case Series of Autoimmune Pancreatitis and IgG4-Related Sclerosing Cholangitis. ⁶²	Nadi A...Rouibaa F	35949783	2022
50	MRI features for differentiation of autoimmune pancreatitis from pancreatic ductal adenocarcinoma: A systematic review and meta-analysis. ⁶²	Ha J...Kim HJ	34903501	2022

Sources

Genes for Autoimmune Pancreatitis

Genes related to Autoimmune Pancreatitis (0 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IL33	Interleukin 33	Protein Coding	13.11	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	IFNA1	Interferon Alpha 1	Protein Coding	12.42	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	MIR21	MicroRNA 21	RNA Gene	11.17	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	ENPP2	Ectonucleotide Pyrophosphatase/Phosphodiesterase 2	Protein Coding	10.5	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.88	DISEASES inferred ¹⁴ ¹⁴
6	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	7.28	DISEASES inferred ¹⁴ ¹⁴
7	SPINK1	Serine Peptidase Inhibitor Kazal Type 1	Protein Coding	7.26	DISEASES inferred ¹⁴
8	CA2	Carbonic Anhydrase 2	Protein Coding	7.24	DISEASES inferred ¹⁴
9	PRSS1	Serine Protease 1	Protein Coding	7.09	DISEASES inferred ¹⁴
10	CELA1	Chymotrypsin Like Elastase 1	Protein Coding	6.73	DISEASES inferred ¹⁴
11	CELA3B	Chymotrypsin Like Elastase 3B	Protein Coding	6.63	DISEASES inferred ¹⁴
12	PRSS58	Serine Protease 58	Protein Coding	6.48	DISEASES inferred ¹⁴
13	CD4	CD4 Molecule	Protein Coding	6.16	DISEASES inferred ¹⁴
14	UBR2	Ubiquitin Protein Ligase E3 Component N-Recognin 2	Protein Coding	6.14	DISEASES inferred ¹⁴
15	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	6.11	DISEASES inferred ¹⁴
16	FCRL3	Fc Receptor Like 3	Protein Coding	6.1	DISEASES inferred ¹⁴
17	SCT	Secretin	Protein Coding	5.89	DISEASES inferred ¹⁴
18	CRP	C-Reactive Protein	Protein Coding	5.84	DISEASES inferred ¹⁴
19	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.78	DISEASES inferred ¹⁴
20	IL10	Interleukin 10	Protein Coding	5.76	DISEASES inferred ¹⁴
21	ANXA11	Annexin A11	Protein Coding	5.7	DISEASES inferred ¹⁴
22	SDC1	Syndecan 1	Protein Coding	5.66	DISEASES inferred ¹⁴
23	ENO1	Enolase 1	Protein Coding	5.65	DISEASES inferred ¹⁴

Sources

Variations for Autoimmune Pancreatitis

Cosmic variations for Autoimmune Pancreatitis:

⁸ (show all 23)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM114951681	NFE2L2	kidney,NS,carcinoma,Type 2	c.197A>G	p.E66G	2:177234072-177234072	3
2	COSM100298136	NFE2L2	kidney,NS,carcinoma,Type 2	c.197A>G	p.E66G	2:177234072-177234072	3
3	COSM106501511	NFE2L2	kidney,NS,carcinoma,Type 2	c.197A>G	p.E66G	2:177234072-177234072	3
4	COSM112705743	NFE2L2	kidney,NS,carcinoma,Type 2	c.197A>G	p.E66G	2:177234072-177234072	3
5	COSM100290763	NFE2L2	kidney,NS,carcinoma,Type 2	c.245A>G	p.E82G	2:177234072-177234072	3
6	COSM102553435	MET	kidney,NS,carcinoma,Type 1	c.3749T>C	p.M1250T	7:116783420-116783420	2
7	COSM102557035	MET	kidney,NS,carcinoma,Type 1	c.3422C>G	p.S1141W	7:116778857-116778857	2
8	COSM88843775	MET	kidney,NS,carcinoma,Type 1	c.3803T>C	p.M1268T	7:116783420-116783420	2
9	COSM88850571	MET	kidney,NS,carcinoma,Type 1	c.3637C>T	p.L1213F	7:116782048-116782048	2
10	COSM102558765	MET	kidney,NS,carcinoma,Type 1	c.3562G>T	p.V1188L	7:116782027-116782027	2
11	COSM88845447	MET	kidney,NS,carcinoma,Type 1	c.3742T>C	p.Y1248H	7:116783359-116783359	2
12	COSM88854098	MET	kidney,NS,carcinoma,Type 1	c.3538C>T	p.H1180Y	7:116778919-116778919	2
13	COSM88844618	MET	kidney,NS,carcinoma,Type 1	c.3328G>A	p.V1110I	7:116777403-116777403	2
14	COSM88846612	MET	kidney,NS,carcinoma,Type 1	c.3476C>G	p.S1159W	7:116778857-116778857	2
15	COSM102555469	MET	kidney,NS,carcinoma,Type 1	c.3688T>C	p.Y1230H	7:116783359-116783359	2
16	COSM102561867	MET	kidney,NS,carcinoma,Type 1	c.3583C>T	p.L1195F	7:116782048-116782048	2
17	COSM102554703	MET	kidney,NS,carcinoma,Type 1	c.3274G>A	p.V1092I	7:116777403-116777403	2
18	COSM88857375	MET	kidney,NS,carcinoma,Type 1	c.3446T>C	p.M1149T	7:116778827-116778827	2
19	COSM102566238	MET	kidney,NS,carcinoma,Type 1	c.3484C>T	p.H1162Y	7:116778919-116778919	2
20	COSM88849805	MET	kidney,NS,carcinoma,Type 1	c.3637C>A	p.L1213I	7:116782048-116782048	2
21	COSM102569465	MET	kidney,NS,carcinoma,Type 1	c.3392T>C	p.M1131T	7:116778827-116778827	2
22	COSM102560896	MET	kidney,NS,carcinoma,Type 1	c.3583C>A	p.L1195I	7:116782048-116782048	2
23	COSM88848019	MET	kidney,NS,carcinoma,Type 1	c.3616G>T	p.V1206L	7:116782027-116782027	2

Sources

Expression for Autoimmune Pancreatitis

Search GEO for disease gene expression data for Autoimmune Pancreatitis.

Sources

Pathways for Autoimmune Pancreatitis

Pathways related to Autoimmune Pancreatitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.18	IL10 ICOSLG CRP
2	Innate Lymphoid Cells Differentiation ⁶⁵	10.83	IL33 IL10 CD4 CCR6
3	Th2 Differentiation ⁶⁵	10.79	IL33 IL10 CD4

Sources

GO Terms for Autoimmune Pancreatitis

Cellular components related to Autoimmune Pancreatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.93	SPINK1 SCT PRSS58 PRSS1 IL33 IL10
2	extracellular space	GO:0005615	9.62	SPINK1 SCT PRSS1 MIR21 IL33 IL10

Biological processes related to Autoimmune Pancreatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	type 2 immune response	GO:0042092	9.26	IL33 IL10
2	positive regulation of pancreatic juice secretion	GO:0090187	8.92	SPINK1 SCT

Molecular functions related to Autoimmune Pancreatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type peptidase activity	GO:0008236	8.92	PRSS58 PRSS1 CELA3B CELA1

Sources

Sources for Autoimmune Pancreatitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

AIP MCID: ATM024 MIFTS: 48	Autoimmune Pancreatitis (AIP) Categories: Bone diseases, Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Infectious diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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