MCID: ATM098
MIFTS: 32

Autoimmune Peripheral Neuropathy

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Autoimmune Peripheral Neuropathy

MalaCards integrated aliases for Autoimmune Peripheral Neuropathy:

Name: Autoimmune Peripheral Neuropathy 12 77 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040087

Summaries for Autoimmune Peripheral Neuropathy

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that results in peripheral neuropathy.

MalaCards based summary : Autoimmune Peripheral Neuropathy is related to peripheral nervous system disease and guillain-barre syndrome. An important gene associated with Autoimmune Peripheral Neuropathy is MPZ (Myelin Protein Zero), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. Affiliated tissues include brain, spinal cord and t cells, and related phenotypes are hematopoietic system and behavior/neurological

Wikipedia : 77 Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the... more...

Related Diseases for Autoimmune Peripheral Neuropathy

Diseases related to Autoimmune Peripheral Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 30.7 GJB1 MAG MPZ
2 guillain-barre syndrome 11.3
3 charcot-marie-tooth disease, demyelinating, type 1f 10.4 GJB1 MPZ
4 charcot-marie-tooth disease, axonal, type 2f 10.4 GJB1 MPZ
5 charcot-marie-tooth disease, axonal, type 2d 10.3 GJB1 MPZ
6 charcot-marie-tooth disease, x-linked dominant, 1 10.3 GJB1 MPZ
7 autoimmune neuropathy 10.3 CD1E MAG
8 charcot-marie-tooth disease, demyelinating, type 1c 10.3 GJB1 MPZ
9 charcot-marie-tooth disease, demyelinating, type 1b 10.3 GJB1 MPZ
10 charcot-marie-tooth disease, axonal, type 2b 10.3 GJB1 MPZ
11 motor peripheral neuropathy 10.3 GJB1 MPZ
12 sensory peripheral neuropathy 10.2 GJB1 MAG MPZ
13 acute cervicitis 10.2 CD86 CXCL10
14 charcot-marie-tooth disease, demyelinating, type 1a 10.2 GJB1 MPZ
15 wallerian degeneration 10.2 CLU MAG MPZ
16 neuropathy 10.2
17 polyradiculoneuropathy 10.2 MAG MPZ PRF1
18 autoimmune disease of peripheral nervous system 10.2 CD1E MAG RPS19
19 sulfamethoxazole allergy 10.2 CD80 CD86
20 neuritis 10.2 CXCL10 MAG MPZ
21 autoimmune addison disease 10.2 AIRE CTLA4
22 type 1 diabetes mellitus 17 10.2 AIRE CTLA4
23 type 1 diabetes mellitus 6 10.1 CD80 CD86
24 myositis fibrosa 10.1 CD80 CD86
25 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 IFNB1 MPZ
26 apple allergy 10.1 CXCL10 FOXP3
27 demyelinating disease 10.0 CXCL10 IFNB1 MAG
28 paracoccidioidomycosis 9.9 CD86 CTLA4 CXCL10
29 alopecia areata 9.9 AIRE CTLA4 CXCL10
30 type 1 diabetes mellitus 13 9.9 CD80 CD86 CTLA4
31 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9 AIRE CTLA4 FOXP3
32 autoimmune disease of endocrine system 9.9 AIRE CTLA4 FOXP3
33 neuroretinitis 9.8 CTLA4 IFNB1
34 diabetes mellitus, insulin-dependent 9.7 AIRE CTLA4 FOXP3
35 vulvar melanoma 9.6 CTLA4 FOXP3
36 autoimmune disease of central nervous system 9.5 CD80 CXCL10 FOXP3 IFNB1 MAG
37 mycosis fungoides 9.4 CD28 CLU CTLA4 CXCL10
38 common variable immunodeficiency 9.4 CD28 CD86 CTLA4 FOXP3
39 rheumatoid arthritis 9.1 CD28 CD80 CD86 CTLA4 FOXP3
40 multiple sclerosis 8.6 CD80 CD86 CTLA4 CXCL10 FOXP3 IFNB1
41 systemic lupus erythematosus 8.4 CD28 CD80 CD86 CTLA4 CXCL10 FCGR2A

Graphical network of the top 20 diseases related to Autoimmune Peripheral Neuropathy:



Diseases related to Autoimmune Peripheral Neuropathy

Symptoms & Phenotypes for Autoimmune Peripheral Neuropathy

MGI Mouse Phenotypes related to Autoimmune Peripheral Neuropathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 AIRE CD28 CD80 CD86 CTLA4 CXCL10
2 behavior/neurological MP:0005386 10.02 AIRE CD28 CD86 CLU FOXP3 GJB1
3 homeostasis/metabolism MP:0005376 9.97 AIRE CD28 CD86 CLU CTLA4 CXCL10
4 immune system MP:0005387 9.8 AIRE CD28 CD80 CD86 CLU CTLA4
5 nervous system MP:0003631 9.4 AIRE CD28 CD80 CD86 CLU CXCL10

Drugs & Therapeutics for Autoimmune Peripheral Neuropathy

Search Clinical Trials , NIH Clinical Center for Autoimmune Peripheral Neuropathy

Genetic Tests for Autoimmune Peripheral Neuropathy

Anatomical Context for Autoimmune Peripheral Neuropathy

MalaCards organs/tissues related to Autoimmune Peripheral Neuropathy:

42
Brain, Spinal Cord, T Cells

Publications for Autoimmune Peripheral Neuropathy

Articles related to Autoimmune Peripheral Neuropathy:

# Title Authors Year
1
Effector/memory CD8+ T cells synergize with co-stimulation competent macrophages to trigger autoimmune peripheral neuropathy. ( 29627532 )
2018
2
Occupational Exposure to Swine, Poultry, and Cattle and Antibody Biomarkers of Campylobacter jejuni Exposure and Autoimmune Peripheral Neuropathy. ( 26636679 )
2015
3
Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. ( 23487421 )
2013
4
Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. ( 22490868 )
2012
5
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. ( 19221395 )
2009
6
IgM paraproteinemia and autoimmune peripheral neuropathy. ( 6262643 )
1981

Variations for Autoimmune Peripheral Neuropathy

Expression for Autoimmune Peripheral Neuropathy

Search GEO for disease gene expression data for Autoimmune Peripheral Neuropathy.

Pathways for Autoimmune Peripheral Neuropathy

Pathways related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 CD28 CD80 CD86 CTLA4 FOXP3 PRF1
2 12.38 CD28 CTLA4 CXCL10 FOXP3
3
Show member pathways
12.24 CD28 CD80 CD86 CTLA4
4
Show member pathways
12.06 CD28 CD80 CD86 CTLA4
5
Show member pathways
11.87 CD28 CD80 CD86
6 11.84 CXCL10 FCGR2A MAG RTN4R
7 11.8 CD28 CD80 CD86 FCGR2A
8
Show member pathways
11.74 CD28 CD80 CD86 PRF1
9 11.63 CD28 CD80 CD86 CTLA4
10 11.47 CD28 CD80 CD86 CTLA4
11 11.45 CD28 CD80 CD86 CTLA4
12 11.41 CD80 CD86 CXCL10 FCGR2A
13 11.4 CD80 CD86 CXCL10
14 11.26 CD28 CD80 CD86 CTLA4 MAG MPZ
15 11.22 CD28 CD80 CD86 CTLA4
16 11.21 CD28 CD80 CD86
17 11.17 CD28 CD80 CD86
18 11.03 CD28 PRF1
19 10.92 CD28 CD80 CD86 FOXP3

GO Terms for Autoimmune Peripheral Neuropathy

Cellular components related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.55 CD28 CD80 CD86 CTLA4 CXCL10
2 cell surface GO:0009986 9.35 CD28 CD80 CD86 CLU RTN4R
3 protein complex involved in cell adhesion GO:0098636 8.8 CD28 CD80 CTLA4
4 membrane GO:0016020 10.13 CD1E CD28 CD80 CD86 CLU CTLA4
5 plasma membrane GO:0005886 10 CD1E CD28 CD80 CD86 CTLA4 FCGR2A

Biological processes related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.84 CD1E CD86 CTLA4 IFNB1
2 cytokine-mediated signaling pathway GO:0019221 9.83 CD80 CD86 CXCL10 IFNB1
3 response to virus GO:0009615 9.71 CLU CXCL10 FOXP3 IFNB1
4 immune response GO:0006955 9.7 AIRE CD1E CD28 CD80 CD86 CTLA4
5 positive regulation of T cell proliferation GO:0042102 9.65 CD28 CD80 CD86
6 humoral immune response GO:0006959 9.63 AIRE CD28 IFNB1
7 negative regulation of axonogenesis GO:0050771 9.58 MAG RTN4R
8 positive regulation of interleukin-4 production GO:0032753 9.57 CD28 FOXP3
9 negative regulation of axon extension GO:0030517 9.56 MAG RTN4R
10 T cell costimulation GO:0031295 9.56 CD28 CD80 CD86 CTLA4
11 negative regulation of immune response GO:0050777 9.55 CTLA4 FOXP3
12 regulation of regulatory T cell differentiation GO:0045589 9.54 CD28 CTLA4 FOXP3
13 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.51 MAG MPZ
14 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.5 CD28 CD80 CD86
15 negative thymic T cell selection GO:0045060 9.49 AIRE CD28
16 regulatory T cell differentiation GO:0045066 9.43 CD28 FOXP3
17 cell surface receptor signaling pathway GO:0007166 9.43 CD28 CD80 CD86 CXCL10 IFNB1 RTN4R
18 negative regulation of T cell proliferation GO:0042130 8.92 CD80 CD86 CTLA4 FOXP3

Molecular functions related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ganglioside GT1b binding GO:1905576 8.96 MAG RTN4R
2 coreceptor activity GO:0015026 8.8 CD28 CD80 CD86

Sources for Autoimmune Peripheral Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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