MCID: ATM098
MIFTS: 31

Autoimmune Peripheral Neuropathy

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Peripheral Neuropathy

MalaCards integrated aliases for Autoimmune Peripheral Neuropathy:

Name: Autoimmune Peripheral Neuropathy 12 73 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040087

Summaries for Autoimmune Peripheral Neuropathy

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that results in peripheral neuropathy.

MalaCards based summary : Autoimmune Peripheral Neuropathy is related to wallerian degeneration and chronic inflammatory demyelinating polyradiculoneuropathy. An important gene associated with Autoimmune Peripheral Neuropathy is MPZ (Myelin Protein Zero), and among its related pathways/superpathways are Allograft rejection and Immune response NFAT in immune response. Affiliated tissues include spinal cord, thymus and skin, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the... more...

Related Diseases for Autoimmune Peripheral Neuropathy

Diseases in the Rare Peripheral Neuropathy family:

Autoimmune Peripheral Neuropathy Acquired Peripheral Neuropathy
Infectious Disease with Peripheral Neuropathy Rare Hereditary Systemic Disease with Peripheral Neuropathy
Rare Hereditary Disease with Peripheral Neuropathy

Diseases related to Autoimmune Peripheral Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 wallerian degeneration 30.5 MPZ MAG
2 chronic inflammatory demyelinating polyradiculoneuropathy 30.5 MPZ ICOSLG
3 polyneuropathy 30.1 MPZ MAG GJB1
4 peripheral nervous system disease 29.6 PMP2 MPZ MAG ICOSLG GJB1 CD4
5 autoimmune disease 29.3 ICOSLG CD86 CD80 CD28 AIRE
6 autoimmune neuropathy 29.1 PMP2 MPZ MAG ICOSLG CD86 CD4
7 guillain-barre syndrome 11.2
8 neuropathy 10.4
9 autoimmune cardiomyopathy 10.2 ICOSLG CD28
10 wissler-fanconi syndrome 10.2 CD4 AIRE
11 dendritic cell thymoma 10.2 CD4 AIRE
12 angular cheilitis 10.2 CD4 AIRE
13 esophageal candidiasis 10.2 CD4 AIRE
14 anal spasm 10.2 CD4 AIRE
15 polyradiculopathy 10.2 ICOSLG CD4
16 cerebral lymphoma 10.2 MAG CD4
17 mononeuritis of upper limb and mononeuritis multiplex 10.2 MAG CD4
18 mononeuritis multiplex 10.2 MAG CD4
19 dacryoadenitis 10.2 ICOSLG CD4
20 type 1 diabetes mellitus 21 10.2 CD28 CD276
21 alopecia universalis congenita 10.2 CD4 AIRE
22 legume allergy 10.2 ICOSLG CD4
23 fruit allergy 10.2 ICOSLG CD4
24 charcot-marie-tooth disease, dominant intermediate a 10.2 MPZ GJB1
25 slowed nerve conduction velocity, autosomal dominant 10.2 MPZ GJB1
26 charcot-marie-tooth disease, x-linked recessive, 2 10.1 MPZ GJB1
27 acute proliferative glomerulonephritis 10.1 ICOSLG CD4
28 chronic conjunctivitis 10.1 ICOSLG CD4
29 charcot-marie-tooth disease, axonal, type 2w 10.1 MPZ GJB1
30 autoimmune glomerulonephritis 10.1 ICOSLG CD4
31 autoimmune disease of urogenital tract 10.1 ICOSLG CD4
32 demyelinating polyneuropathy 10.1
33 charcot-marie-tooth disease, axonal, type 2i 10.1 MPZ GJB1
34 immunodeficiency 13 10.1 ICOSLG CD4
35 charcot-marie-tooth disease intermediate type 10.1 MPZ GJB1
36 charcot-marie-tooth disease type x 10.1 MPZ GJB1
37 childhood type dermatomyositis 10.1 ICOSLG CD4
38 charcot-marie-tooth disease, dominant intermediate c 10.1 MPZ GJB1
39 urinary schistosomiasis 10.1 ICOSLG CD80
40 autoimmune disease of eyes, ear, nose and throat 10.1 ICOSLG CD4
41 brachial plexus neuropathy 10.1 MPZ GJB1
42 charcot-marie-tooth disease, demyelinating, type 1f 10.1 MPZ GJB1
43 intestinal schistosomiasis 10.1 ICOSLG CD4
44 hereditary motor and sensory neuropathy, type iic 10.1 MPZ GJB1
45 microsporidiosis 10.1 PMP2 CD4
46 primary thrombocytopenia 10.1 ICOSLG CD4
47 charcot-marie-tooth disease, axonal, type 2f 10.1 MPZ GJB1
48 klebsiella pneumonia 10.1 ICOSLG CD4
49 charcot-marie-tooth disease, x-linked dominant, 1 10.1 MPZ GJB1
50 charcot-marie-tooth disease, axonal, type 2d 10.1 MPZ GJB1

Graphical network of the top 20 diseases related to Autoimmune Peripheral Neuropathy:



Diseases related to Autoimmune Peripheral Neuropathy

Symptoms & Phenotypes for Autoimmune Peripheral Neuropathy

MGI Mouse Phenotypes related to Autoimmune Peripheral Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 AIRE CD276 CD28 CD4 CD80 CD86
2 immune system MP:0005387 9.61 AIRE CD276 CD28 CD4 CD80 CD86
3 nervous system MP:0003631 9.28 AIRE CD28 CD4 CD80 CD86 GJB1

Drugs & Therapeutics for Autoimmune Peripheral Neuropathy

Search Clinical Trials , NIH Clinical Center for Autoimmune Peripheral Neuropathy

Genetic Tests for Autoimmune Peripheral Neuropathy

Anatomical Context for Autoimmune Peripheral Neuropathy

MalaCards organs/tissues related to Autoimmune Peripheral Neuropathy:

40
Spinal Cord, Thymus, Skin, T Cells, Bone, Myeloid

Publications for Autoimmune Peripheral Neuropathy

Articles related to Autoimmune Peripheral Neuropathy:

(show all 37)
# Title Authors PMID Year
1
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy. 61
33752705 2021
2
Heat shock protein is a key therapeutic target for nerve repair in autoimmune peripheral neuropathy and severe peripheral nerve injury. 61
32858161 2021
3
Amyopathic dermatomyositis combined with peripheral neuropathy. 61
33257380 2020
4
Selective inhibition of anti-MAG IgM autoantibody binding to myelin by an antigen-specific glycopolymer. 61
32270492 2020
5
High salt diet ameliorates functional, electrophysiological and histological characteristics of murine spontaneous autoimmune polyneuropathy. 61
30468863 2019
6
Effector/memory CD8+ T cells synergize with co-stimulation competent macrophages to trigger autoimmune peripheral neuropathy. 61
29627532 2018
7
Vestibular impairment in chronic inflammatory demyelinating polyneuropathy. 61
29260355 2018
8
The introspection on the diagnosis and treatment process of a case of Guillain-Barré syndrome (GBS) attributed to systemic lupus erythematosus (SLE): A case report. 61
29245299 2017
9
Selective in vivo removal of pathogenic anti-MAG autoantibodies, an antigen-specific treatment option for anti-MAG neuropathy. 61
28416698 2017
10
Autoimmunity in Guillain-Barré syndrome associated with Zika virus infection and beyond. 61
28216074 2017
11
An animal model of Miller Fisher syndrome: Mitochondrial hydrogen peroxide is produced by the autoimmune attack of nerve terminals and activates Schwann cells. 61
27597525 2016
12
Polymorphisms in exon 2 of CD1 genes are associated with susceptibility to Guillain-Barré syndrome. 61
27653862 2016
13
Polymorphisms of Immunoglobulin G Fc Receptors in Pediatric Guillain-Barré Syndrome. 61
27064330 2016
14
Therapeutic immunoglobulin should be dosed by clinical outcome rather than by body weight in obese patients. 61
25731216 2015
15
Occupational Exposure to Swine, Poultry, and Cattle and Antibody Biomarkers of Campylobacter jejuni Exposure and Autoimmune Peripheral Neuropathy. 61
26636679 2015
16
Evidence from Human and Animal Studies: Pathological Roles of CD8(+) T Cells in Autoimmune Peripheral Neuropathies. 61
26528293 2015
17
An electrophysiological classification associated with Guillain-Barré syndrome outcomes. 61
25082629 2014
18
A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome. 61
24401681 2014
19
The basal ganglia in perceptual timing: timing performance in Multiple System Atrophy and Huntington's disease. 61
24135486 2014
20
Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background. 61
23850635 2013
21
Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. 61
23487421 2013
22
Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. 61
22490868 2012
23
[Macroglobulinosis cutis revealing Waldenström macroglobulinemia]. 61
20605286 2011
24
Chronic inflammatory demyelinating polyradiculoneuropathy in a boy with systemic lupus erythematosus. 61
19536546 2010
25
Peripheral autoimmune neuropathy assessed using corneal in vivo confocal microscopy. 61
19273761 2009
26
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. 61
19221395 2009
27
Chemical validation of molecular mimicry: interaction of cholera toxin with Campylobacter lipooligosaccharides. 61
17226101 2007
28
Myelin-associated glycoprotein (MAG): past, present and beyond. 61
17241126 2007
29
Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. 61
16237054 2005
30
Calpain inhibitors protect against axonal degeneration in a model of anti-ganglioside antibody-mediated motor nerve terminal injury. 61
12937083 2003
31
[Difficult diagnosis of autoimmune peripheral neuropathy]. 61
14671759 2003
32
[Intravenous immunoglobulin in multiple sclerosis]. 61
12962026 2003
33
Corticosteroids for chronic inflammatory demyelinating polyradiculoneuropathy. 61
11687011 2001
34
Inter-laboratory validation of an ELISA for the determination of serum anti-ganglioside antibodies. 61
10209353 1999
35
Molecular pathogenesis of peripheral neuropathy. 61
8881422 1996
36
A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18. 61
8636426 1996
37
IgM paraproteinemia and autoimmune peripheral neuropathy. 61
6262643 1981

Variations for Autoimmune Peripheral Neuropathy

Expression for Autoimmune Peripheral Neuropathy

Search GEO for disease gene expression data for Autoimmune Peripheral Neuropathy.

Pathways for Autoimmune Peripheral Neuropathy

Pathways related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 ICOSLG CD86 CD80 CD4 CD28
2
Show member pathways
12.47 ICOSLG CD86 CD80 CD4 CD28
3
Show member pathways
12.44 CD86 CD80 CD4 CD28
4
Show member pathways
12.15 ICOSLG CD86 CD80 CD4 CD28
5 11.82 CD86 CD80 CD4 CD28
6
Show member pathways
11.79 ICOSLG CD86 CD80 CD4 CD28
7
Show member pathways
11.77 CD86 CD80 CD4 CD28
8 11.68 CD86 CD80 CD28
9
Show member pathways
11.66 CD86 CD80 CD4 CD28
10
Show member pathways
11.5 CD86 CD80 CD4 CD28
11 11.41 CD86 CD80 CD4 CD28
12 11.4 MPZ MAG ICOSLG CD86 CD80 CD4
13 11.21 CD86 CD80 CD28
14 11.17 CD86 CD80 CD28
15 11 CD4 CD28
16 10.92 CD86 CD80 CD4 CD28

GO Terms for Autoimmune Peripheral Neuropathy

Cellular components related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.91 MPZ MAG ICOSLG GJB1 CD86 CD80
2 protein complex involved in cell adhesion GO:0098636 9.16 CD80 CD28
3 myelin sheath GO:0043209 9.13 PMP2 MPZ MAG
4 external side of plasma membrane GO:0009897 9.1 ICOSLG CD86 CD80 CD4 CD28 CD276

Biological processes related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.77 CD86 CD80 CD4 CD28 AIRE
2 cell surface receptor signaling pathway GO:0007166 9.71 CD86 CD80 CD4 CD28
3 positive regulation of protein kinase B signaling GO:0051897 9.67 CD86 CD80 CD28
4 T cell receptor signaling pathway GO:0050852 9.62 ICOSLG CD4 CD28 CD276
5 T cell costimulation GO:0031295 9.56 ICOSLG CD86 CD80 CD28
6 B cell activation GO:0042113 9.51 ICOSLG CD86
7 regulation of defense response to virus by virus GO:0050690 9.48 CD4 CD28
8 positive regulation of interleukin-4 production GO:0032753 9.46 CD86 CD28
9 T cell activation GO:0042110 9.46 ICOSLG CD4 CD28 CD276
10 negative thymic T cell selection GO:0045060 9.43 CD28 AIRE
11 positive regulation of interleukin-2 production GO:0032743 9.26 CD86 CD80 CD4 CD28
12 positive regulation of T cell proliferation GO:0042102 9.02 CD86 CD80 CD4 CD28 CD276

Molecular functions related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 MAG ICOSLG CD4 CD276
2 virus receptor activity GO:0001618 9.13 CD86 CD80 CD4
3 coreceptor activity GO:0015026 8.92 CD86 CD80 CD4 CD28

Sources for Autoimmune Peripheral Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....