MCID: ATM098
MIFTS: 28

Autoimmune Peripheral Neuropathy

Categories: Immune diseases, Neuronal diseases

Aliases & Classifications for Autoimmune Peripheral Neuropathy

MalaCards integrated aliases for Autoimmune Peripheral Neuropathy:

Name: Autoimmune Peripheral Neuropathy 12 76 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040087

Summaries for Autoimmune Peripheral Neuropathy

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that results in peripheral neuropathy.

MalaCards based summary : Autoimmune Peripheral Neuropathy is related to peripheral nervous system disease and guillain-barre syndrome. An important gene associated with Autoimmune Peripheral Neuropathy is MPZ (Myelin Protein Zero), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include t cells, and related phenotypes are hematopoietic system and behavior/neurological

Wikipedia : 76 Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation,... more...

Related Diseases for Autoimmune Peripheral Neuropathy

Diseases related to Autoimmune Peripheral Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 30.5 GJB1 MAG MPZ
2 guillain-barre syndrome 11.2
3 autoimmune neuropathy 10.2 CD1E MAG
4 charcot-marie-tooth disease, demyelinating, type 1f 10.2 GJB1 MPZ
5 charcot-marie-tooth disease, axonal, type 2f 10.2 GJB1 MPZ
6 charcot-marie-tooth disease, axonal, type 2d 10.2 GJB1 MPZ
7 charcot-marie-tooth disease, x-linked dominant, 1 10.2 GJB1 MPZ
8 charcot-marie-tooth disease, demyelinating, type 1c 10.2 GJB1 MPZ
9 neuropathy 10.2
10 charcot-marie-tooth disease, demyelinating, type 1b 10.2 GJB1 MPZ
11 charcot-marie-tooth disease, axonal, type 2b 10.2 GJB1 MPZ
12 motor peripheral neuropathy 10.2 GJB1 MPZ
13 charcot-marie-tooth disease, demyelinating, type 1a 10.1 GJB1 MPZ
14 charcot-marie-tooth disease, demyelinating, type 1d 10.1 GJB1 MPZ
15 autoimmune disease of peripheral nervous system 10.1 CD1E MAG RPS19
16 sulfamethoxazole allergy 10.1 CD80 CD86
17 sensory peripheral neuropathy 10.1 GJB1 MAG MPZ
18 acute cervicitis 10.1 CD86 CXCL10
19 neuropathy, hereditary, with liability to pressure palsies 10.1 GJB1 MPZ
20 type 1 diabetes mellitus 13 10.1 CD80 CD86
21 type 1 diabetes mellitus 6 10.1 CD80 CD86
22 myositis fibrosa 10.1 CD80 CD86
23 hereditary motor and sensory neuropathy, type iic 10.1 GJB1 MPZ
24 wallerian degeneration 10.1 CLU MAG MPZ
25 neuritis 10.0 CXCL10 MAG MPZ
26 peripheral demyelinating neuropathy, central dysmyelination, waardenburg syndrome, and hirschsprung disease 10.0 GJB1 MPZ
27 chronic inflammatory demyelinating polyradiculoneuropathy 10.0 IFNB1 MPZ
28 apple allergy 9.9 CXCL10 FOXP3
29 demyelinating disease 9.9 CXCL10 IFNB1 MAG
30 exanthema subitum 9.9 CD80 CD86
31 autoimmune disease 9.7 AIRE CD80 FCGR2A FOXP3
32 immune system disease 9.5 AIRE CD80 CD86 FOXP3 IFNB1
33 autoimmune disease of central nervous system 9.4 CD80 CXCL10 FOXP3 IFNB1 MAG
34 autoimmune disease of the nervous system 9.4 CD80 CXCL10 FOXP3 IFNB1 MAG
35 systemic lupus erythematosus 9.2 CD80 CD86 CXCL10 FCGR2A FOXP3 IFNB1
36 multiple sclerosis 9.1 CD80 CD86 CXCL10 FOXP3 IFNB1 MAG

Graphical network of the top 20 diseases related to Autoimmune Peripheral Neuropathy:



Diseases related to Autoimmune Peripheral Neuropathy

Symptoms & Phenotypes for Autoimmune Peripheral Neuropathy

MGI Mouse Phenotypes related to Autoimmune Peripheral Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 AIRE CD80 CD86 CXCL10 DUSP1 FCGR2A
2 behavior/neurological MP:0005386 9.97 AIRE CD86 CLU DUSP1 FOXP3 GJB1
3 homeostasis/metabolism MP:0005376 9.9 AIRE CD86 CLU CXCL10 DUSP1 FOXP3
4 immune system MP:0005387 9.73 AIRE CD80 CD86 CLU CXCL10 DUSP1
5 nervous system MP:0003631 9.36 AIRE CD80 CD86 CLU CXCL10 DUSP1

Drugs & Therapeutics for Autoimmune Peripheral Neuropathy

Search Clinical Trials , NIH Clinical Center for Autoimmune Peripheral Neuropathy

Genetic Tests for Autoimmune Peripheral Neuropathy

Anatomical Context for Autoimmune Peripheral Neuropathy

MalaCards organs/tissues related to Autoimmune Peripheral Neuropathy:

41
T Cells

Publications for Autoimmune Peripheral Neuropathy

Articles related to Autoimmune Peripheral Neuropathy:

# Title Authors Year
1
Effector/memory CD8+ T cells synergize with co-stimulation competent macrophages to trigger autoimmune peripheral neuropathy. ( 29627532 )
2018
2
Occupational Exposure to Swine, Poultry, and Cattle and Antibody Biomarkers of Campylobacter jejuni Exposure and Autoimmune Peripheral Neuropathy. ( 26636679 )
2015
3
Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by Aire deficiency. ( 23487421 )
2013
4
Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathy. ( 22490868 )
2012
5
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. ( 19221395 )
2009
6
IgM paraproteinemia and autoimmune peripheral neuropathy. ( 6262643 )
1981

Variations for Autoimmune Peripheral Neuropathy

Expression for Autoimmune Peripheral Neuropathy

Search GEO for disease gene expression data for Autoimmune Peripheral Neuropathy.

Pathways for Autoimmune Peripheral Neuropathy

GO Terms for Autoimmune Peripheral Neuropathy

Cellular components related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.43 AIRE CD80 CLU CXCL10 FOXP3 RPS19
2 cell surface GO:0009986 9.02 CD1E CD80 CD86 CLU RTN4R

Biological processes related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.65 CD80 CD86 CXCL10
2 immune response GO:0006955 9.65 AIRE CD1E CD80 CD86 CXCL10
3 cytokine-mediated signaling pathway GO:0019221 9.62 CD80 CD86 CXCL10 IFNB1
4 negative regulation of axonogenesis GO:0050771 9.46 MAG RTN4R
5 negative regulation of axon extension GO:0030517 9.43 MAG RTN4R
6 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.4 CD80 CD86
7 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.37 MAG MPZ
8 negative regulation of T cell proliferation GO:0042130 9.33 CD80 CD86 FOXP3
9 response to virus GO:0009615 9.26 CLU CXCL10 FOXP3 IFNB1
10 cell surface receptor signaling pathway GO:0007166 9.02 CD80 CD86 CXCL10 IFNB1 RTN4R

Molecular functions related to Autoimmune Peripheral Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.96 CD80 CD86
2 ganglioside GT1b binding GO:1905576 8.62 MAG RTN4R

Sources for Autoimmune Peripheral Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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