Autoimmune Uveitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ATM099 MIFTS: 45	Autoimmune Uveitis Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Autoimmune Uveitis

MalaCards integrated aliases for Autoimmune Uveitis:

Name: Autoimmune Uveitis ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Immune diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0040088

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Summaries for Autoimmune Uveitis

Disease Ontology : ¹² An autoimmune disease of eyes, ear, nose and throat that is located in the uvea.

MalaCards based summary : Autoimmune Uveitis is related to vitreoretinopathy, neovascular inflammatory and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Autoimmune Uveitis is TRIB2 (Tribbles Pseudokinase 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Metformin and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include uvea, t cells and eye, and related phenotypes are growth/size/body region and homeostasis/metabolism

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Related Diseases for Autoimmune Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis	Posterior Uveitis
Intermediate Uveitis	Infectious Anterior Uveitis
Infectious Posterior Uveitis	Systemic Diseases with Anterior Uveitis
Systemic Diseases with Posterior Uveitis

Diseases related to Autoimmune Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 585)

#	Related Disease	Score	Top Affiliating Genes
1	vitreoretinopathy, neovascular inflammatory	31.2	TGFB2 RPE65 RLBP1 CRYAA CCL2 CAPN5
2	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	31.1	IL17A IL10 IFNG
3	pertussis	30.8	TNF IL1B IL10 CCL2
4	allergic encephalomyelitis	30.7	CCL3 CCL2
5	posterior uveitis	30.7	TNF SAG RBP3 IL4 IL2 IFNG
6	neuroretinitis	30.7	SAG CAPN5
7	iridocyclitis	30.5	TNF RBP3 IL1B IL17A IL10
8	panuveitis	30.4	TNF SAG RBP3 IL17A IL10
9	vasculitis	30.4	TNF IL17A ICAM1 CCL2
10	sympathetic ophthalmia	30.4	TNF RBP3 IL10 ICAM1
11	retinal degeneration	30.3	SAG RPE65 RLBP1 RBP3 CAPN5
12	macular retinal edema	30.2	TNF IL1B ICAM1 CRYAA CCL2
13	cytomegalovirus retinitis	30.2	TNF IL10 IFNG
14	retinal detachment	30.1	TNF IL10 IFNG CCL2 CAPN5
15	choroiditis	30.1	TNF SAG RBP3 IL17A IL10 IFNG
16	vogt-koyanagi-harada disease	30.1	IL17A IL10 IFNG
17	retinal vascular disease	30.1	TNF IL1B ICAM1 CRYAA CCL2
18	retinal vasculitis	30.0	TNF SAG RBP3 CCL2
19	ocular hypertension	30.0	TGFB2 RLBP1 CRYAA
20	retinal vein occlusion	30.0	TNF IL1B CCL2
21	uveitis	29.9	TRIB2 TNF TGFB2 SAG RBP3 IL4
22	allergic disease	29.9	TNF TGFB2 IL4 IL2 IL1B IFNG
23	cholera	29.8	TNF IL4 IL1B IL10
24	endophthalmitis	29.8	TNF SAG IL1B ICAM1 CRYAA
25	hashimoto thyroiditis	29.8	IL4 IL17A IL10 IFNG ICAM1
26	graft-versus-host disease	29.8	TNF IL2 IL1B IL10 IFNG
27	microvascular complications of diabetes 1	29.8	TGFB2 ICAM1 CRYAA CCL2
28	spondylitis	29.8	TNF IL1B IL17A IL10 IFNG
29	reactive arthritis	29.8	TNF IL1B IL17A IL10 IFNG
30	sarcoidosis 1	29.8	TNF IL2 IL1B IFNG ICAM1 CCL3
31	gastroenteritis	29.8	TNF IL4 IL1B IL10 IFNG
32	retinal disease	29.8	SAG RPE65 RLBP1 CRYAA
33	scleritis	29.7	TNF IL4 IL22 IFNG CCL2
34	thyroiditis	29.7	TNF IL4 IL2 IL1B IL17A IL10
35	autoimmune disease	29.6	TNF SAG RBP3 IL4 IL22 IL2
36	neutropenia	29.6	TNF IL4 IL2 IL1B IL10 IFNG
37	juvenile rheumatoid arthritis	29.6	TNF IL2 IL1B IL10 IFNG CCL2
38	toxoplasmosis	29.5	TNF IL4 IL1B IL10 IFNG CCL3
39	chorioretinitis	29.4	TNF SAG RBP3 IL2 IL1B IL17A
40	proteasome-associated autoinflammatory syndrome 1	29.2	TNF IL4 IL1B IL17A IL10 IFNG
41	body mass index quantitative trait locus 11	29.1	TNF IL4 IL1B IL17A IL10 ICAM1
42	ulcerative colitis	29.0	TNF IL4 IL22 IL2 IL1B IL17A
43	eye disease	28.9	TNF TGFB2 SAG RPE65 RBP3 IL4
44	crohn's disease	28.8	TNF IL4 IL22 IL2 IL1B IL17A
45	demyelinating disease	28.7	TNF IL4 IL2 IL1B IL17A IL10
46	macular degeneration, age-related, 1	28.6	TNF TGFB2 SAG RPE65 RLBP1 RBP3
47	inflammatory bowel disease	28.5	TNF IL4 IL22 IL2 IL1B IL17A
48	retinitis pigmentosa	28.3	TNF SAG RPE65 RLBP1 RBP3 IL4
49	yemenite deaf-blind hypopigmentation syndrome	10.6
50	acute zonal occult outer retinopathy	10.5	SAG RLBP1

Graphical network of the top 20 diseases related to Autoimmune Uveitis:

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Symptoms & Phenotypes for Autoimmune Uveitis

MGI Mouse Phenotypes related to Autoimmune Uveitis:

⁴⁶ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.32	CAPN5 ICAM1 IFNG IL10 IL17A IL1B
2	homeostasis/metabolism	MP:0005376	10.31	ICAM1 IFNG IL10 IL17A IL1B IL2
3	immune system	MP:0005387	10.28	CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
4	hematopoietic system	MP:0005397	10.23	ICAM1 IFNG IL10 IL17A IL1B IL2
5	craniofacial	MP:0005382	10.16	IFNG IL10 IL17A IL1B IL4 RLBP1
6	digestive/alimentary	MP:0005381	10.15	ICAM1 IFNG IL10 IL17A IL2 IL22
7	integument	MP:0010771	10.07	ICAM1 IFNG IL10 IL17A IL1B IL22
8	nervous system	MP:0003631	10.03	ICAM1 IFNG IL10 IL1B IL4 RBP3
9	neoplasm	MP:0002006	9.87	ICAM1 IFNG IL10 IL1B IL2 IL22
10	no phenotypic analysis	MP:0003012	9.76	IFNG IL10 IL17A IL2 IL22 IL4
11	respiratory system	MP:0005388	9.56	IFNG IL10 IL17A IL2 IL22 IL4
12	vision/eye	MP:0005391	9.4	ICAM1 IFNG IL10 IL2 IL4 RBP3

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Drugs & Therapeutics for Autoimmune Uveitis

Drugs for Autoimmune Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Metformin

Approved

657-24-9

14219 4091

Curcumin

Approved, Experimental, Investigational

Early Phase 1

458-37-7

969516

Methotrexate

Approved

1959-05-2, 59-05-2

126941

Adalimumab

Approved, Experimental

331731-18-1

16219006

Mycophenolic acid

Approved

24280-93-1

446541

Tacrolimus

Approved, Investigational

104987-11-3

445643 439492 6473866

Sirolimus

Approved, Investigational

53123-88-9

5284616 6436030

Chlorambucil

Approved

305-03-3

2708

Azathioprine

Approved

446-86-6

2265

Cyclophosphamide

Approved, Investigational

50-18-0, 6055-19-2

2907

Infliximab

Approved

170277-31-3

Hypoglycemic Agents

glucocorticoids

Anti-Inflammatory Agents

Immunologic Factors

Antimetabolites

Immunosuppressive Agents

Cyclosporins

Alkylating Agents

Calcineurin Inhibitors

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Multicenter, Randomized, Controlled Clinical Trial Research Evaluating the Use of Combination Therapy of Glucocorticoids and Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis	Recruiting	NCT03525028		Metformin;Placebo
2	Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis: a Multicenter Randomized, Placebo Controlled, Double-blind Clinical Study	Active, not recruiting	NCT03584724	Early Phase 1	Norflo Oro;Placebo for Norflo Oro
3	Pilot Project: The Amplicon and Metatranscriptomic Next-generation Sequencing of Samples From Intra and Extra-intestinal Microbiome in Non-infectious Uveitis Patients to Decipher Possibility Uveitis Pathogenesis	Not yet recruiting	NCT04126850
4	Treatment Outcome of Uveitis in Autoimmune Diseases	Not yet recruiting	NCT03886233		Corticosteroid Series

Search NIH Clinical Center for Autoimmune Uveitis

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Genetic Tests for Autoimmune Uveitis

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Anatomical Context for Autoimmune Uveitis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Uveitis:

¹⁹

Uvea

MalaCards organs/tissues related to Autoimmune Uveitis:

⁴⁰

T Cells, Eye, Retina, B Cells, Spleen, Monocytes, Endothelial

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Publications for Autoimmune Uveitis

Articles related to Autoimmune Uveitis:

(show top 50) (show all 879)

#	Title	Authors	PMID	Year
1	Characterization of Clinical and Immune Responses in an Experimental Chronic Autoimmune Uveitis Model. ⁶¹	Fan NW...Chen Y	32966818	2021
2	Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis. ⁶¹	Chen YH...Calder V	33602234	2021
3	Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB4 Dependence of Retinal Th17 Cells. ⁶¹	Eskandarpour M...Calder VL	33159884	2021
4	Activated γδ T Cells Promote Dendritic Cell Maturation and Exacerbate the Development of Experimental Autoimmune Uveitis (EAU) in Mice. ⁶¹	Wang B...Bi H	31985304	2021
5	Longdan Xiegan Decoction alleviates experimental autoimmune uveitis in rats by inhibiting Notch signaling pathway activation and Th17 cell differentiation. ⁶¹	Yin X...Guo D	33493870	2021
6	Deviant proteome profile of equine granulocytes associates to latent activation status in organ specific autoimmune disease. ⁶¹	Weigand M...Degroote RL	32977044	2021
7	Tregs in Autoimmune Uveitis. ⁶¹	Huang Z...Su W	33523450	2021
8	Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis. ⁶¹	Choi JK...Egwuagu CE	33479912	2021
9	Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis. ⁶¹	Zhong Z...Yang P	32422390	2021
10	Sirolimus-Loaded Intravitreal Implant for Effective Treatment of Experimental Uveitis. ⁶¹	Paiva MRB...Silva-Cunha A	33404988	2021
11	Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic Escherichia coli Nissle 1917. ⁶¹	Dusek O...Heissigerova J	33375578	2020
12	Functionally distinct IFN-γ+ IL-17A+ Th cells in experimental autoimmune uveitis: T-cell heterogeneity, migration, and steroid response. ⁶¹	Chen YH...Calder VL	32652562	2020
13	Identifying Mouse Autoimmune Uveitis from Fundus Photographs Using Deep Learning. ⁶¹	Sun J...Yousefi S	33294300	2020
14	Complete blood count parameters and neutrophil-to-lymphocyte ratio values as markers for differentiation between systemic infectious and non-infectious uveitis. ⁶¹	Yildiz Balci S...Aksaray S	32617803	2020
15	Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation. ⁶¹	Bing SJ...Caspi RR	32593472	2020
16	A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis. ⁶¹	Zhou J...Li X	32569628	2020
17	STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs. ⁶¹	Oladipupo FO...Egwuagu CE	33004854	2020
18	IL-10 and IL-17 expression by CD4+ T cells is altered in corticosteroid refractory immune thrombocytopenia (ITP). ⁶¹	Stimpson ML...Bradbury CA	32574429	2020
19	A cell-permeable peptide inhibitor of p55PIK signaling alleviates ocular inflammation in mouse models of uveitis. ⁶¹	Zhu M...Shen Y	32777209	2020
20	Quantitative proteomic analysis of rat retina with experimental autoimmune uveitis based on tandem mass tag (TMT) peptide labeling coupled with LC-MS/MS. ⁶¹	Liu B...Guo D	32750637	2020
21	Soluble cytokine receptor levels in aqueous humour of patients with specific autoimmune uveitic entities: sCD30 is a biomarker of granulomatous uveitis. ⁶¹	Abu El-Asrar AM...Struyf S	31804623	2020
22	The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24. ⁶¹	Chong WP...Caspi RR	32673565	2020
23	Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation. ⁶¹	Tan J...Hou S	32829384	2020
24	miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15. ⁶¹	Zhang L...Sun Y	32736708	2020
25	Matairesinol ameliorates experimental autoimmune uveitis by suppression of IRBP-specific Th17 cells. ⁶¹	Li X...Mu H	32559555	2020
26	Immunosuppression in the Management of Presumed Non-infective Uveitis; Are We Sure What We are Treating? Notes on the Antimicrobial Properties of the Systemic Immunosuppressants. ⁶¹	Jones NP	31418624	2020
27	Analysis of the role of palmitoleic acid in acute anterior uveitis. ⁶¹	Huang X...Yang P	32422526	2020
28	TIGIT+ A2Ar-Dependent anti-uveitic Treg cells are a novel subset of Tregs associated with resolution of autoimmune uveitis. ⁶¹	Muhammad F...Lee DJ	32201225	2020
29	The Role of Gut Microbiome in Autoimmune Uveitis. ⁶¹	Fu X...Chen D	32674100	2020
30	Proteomics Profiling of Plasma Exosomes in VKH Patients ⁶¹	Zheng H...Zhang X	32682377	2020
31	The relationship between TIGIT+ regulatory T cells and autoimmune disease. ⁶¹	Lee DJ	32172208	2020
32	An Increase of Oxidized Phospholipids and the Role of Macrophages in Intraocular Inflammation. ⁶¹	Hiraoka M...Abe A	32526032	2020
33	Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease. ⁶¹	Ye Z...Yang P	31928124	2020
34	Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice. ⁶¹	Hsu SM...Chen SH	32380695	2020
35	Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide. ⁶¹	He X...Ruan Q	32169850	2020
36	Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis. ⁶¹	Du Z...Yang P	32044663	2020
37	Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach. ⁶¹	Lipski DA...Willermain F	32183784	2020
38	Do epigenetic changes caused by commensal microbiota contribute to development of ocular disease? A review of evidence. ⁶¹	Nayyar A...Danias J	32169120	2020
39	A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina. ⁶¹	Wei J...Caspi RR	32118582	2020
40	DAPT reverses the Th17/Treg imbalance in experimental autoimmune uveitis in vitro via inhibiting Notch signaling pathway. ⁶¹	Yin X...Guo D	31863921	2020
41	Therapeutic potential of aryl hydrocarbon receptor in autoimmunity. ⁶¹	Wang XS...Pan HF	31617124	2020
42	Soluble CD83 Regulates Dendritic Cell-T Cell Immunological Synapse Formation by Disrupting Rab1a-Mediated F-Actin Rearrangement. ⁶¹	Lin W...Li X	33585445	2020
43	Dracocephalum heterophyllum (DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4+ T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis. ⁶¹	Bian J...Ruan Q	33117376	2020
44	Roles of Exosomes in Ocular Diseases. ⁶¹	Liu J...Zhang Z	33402823	2020
45	Aberrant Migratory Behavior of Immune Cells in Recurrent Autoimmune Uveitis in Horses. ⁶¹	Wiedemann C...Deeg CA	32211402	2020
46	Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis. ⁶¹	Kang M...Egwuagu CE	32547555	2020
47	Regulated Tristetraprolin Overexpression Dampens the Development and Pathogenesis of Experimental Autoimmune Uveitis. ⁶¹	Xu B...Caspi RR	33569048	2020
48	Immunological Insights in Equine Recurrent Uveitis. ⁶¹	Degroote RL...Deeg CA	33488614	2020
49	Association between islet autoantibodies and the prevalence of autoimmune uveitis. ⁶¹	Zhang Y...Ma L	33215003	2020
50	Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway. ⁶¹	Chen Y...Liang D	33281814	2020

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Genes for Autoimmune Uveitis

Genes related to Autoimmune Uveitis (0 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TRIB2	Tribbles Pseudokinase 2	Protein Coding	21.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins (show sections)
2	RBP3	Retinol Binding Protein 3	Protein Coding	17.76	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	SAG	S-Antigen Visual Arrestin	Protein Coding	16.22	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CRYAA	Crystallin Alpha A	Protein Coding	14.98	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL17A	Interleukin 17A	Protein Coding	14.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL10	Interleukin 10	Protein Coding	13.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL2	Interleukin 2	Protein Coding	13.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	CAPN5	Calpain 5	Protein Coding	13.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	TNF	Tumor Necrosis Factor	Protein Coding	13.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	IL4	Interleukin 4	Protein Coding	13.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	RLBP1	Retinaldehyde Binding Protein 1	Protein Coding	13.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	IL1B	Interleukin 1 Beta	Protein Coding	13.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	IL22	Interleukin 22	Protein Coding	12.99	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	12.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	12.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	IFNG	Interferon Gamma	Protein Coding	12.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	12.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	12.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	IL22RA1	Interleukin 22 Receptor Subunit Alpha 1	Protein Coding	12.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	IFNA1	Interferon Alpha 1	Protein Coding	11.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	11.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	11.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	11.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Autoimmune Uveitis

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Expression for Autoimmune Uveitis

Search GEO for disease gene expression data for Autoimmune Uveitis.

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Pathways for Autoimmune Uveitis

Pathways related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.1	TNF IL4 IL22RA1 IL22 IL2 IL1B
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.93	TNF TGFB2 IL4 IL22RA1 IL22 IL2
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.78	TNF TGFB2 IL4 IL22RA1 IL22 IL2
4	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.61	TNF TGFB2 IL4 IL22RA1 IL22 IL2
5	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.5	TNF TGFB2 IL4 IL22RA1 IL22 IL2
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.42	TNF IL4 IL22RA1 IL22 IL2 IL1B
7	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.41	TNF TGFB2 IL4 IL22RA1 IL22 IL2
8	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.18	TNF TGFB2 IL2 IL1B IL10 IFNG
9	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.96	TNF IL4 IL22 IL2 IL1B IL17A
10	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.9	TNF IL2 IL1B IFNG ICAM1 CCL2
11	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.74	TNF IL4 IL2 IL1B IL17A IL10
12	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.72	TNF IL2 IL1B IL17A IL10 IFNG
13	Immune response NFAT in immune response ²³ Show member pathways Immune response CD28 signaling ²³ Immune response ICOS pathway in T-helper cell ²³ Immune response T cell receptor signaling pathway ²³	12.69	TNF IL4 IL2 IL10 IFNG
14	NF-kappaB Signaling ⁴	12.62	TRIB2 TNF IL4 IL2 IL1B IL17A
15	Immune response Role of DAP12 receptors in NK cells ²³ Show member pathways Immune response CD16 signaling in NK cells ²³ Natural killer cell mediated cytotoxicity ³⁶	12.59	TNF IL4 IL2 IFNG ICAM1
16	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.56	IL4 IL22RA1 IL22 IL2 IL10 IFNG
17	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.56	TNF TGFB2 IL4 IL22RA1 IL22 IL2
18	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.48	TNF IL4 IL1B IL17A IFNG CCL2
19	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.48	TNF IL4 IL2 IL1B IFNG ICAM1
20	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.47	TNF IL22RA1 IL2 IL10 CCL3 CCL2
21	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.41	TNF TGFB2 IL4 IL1B IL10 IFNG
22	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.4	TNF TGFB2 IL4 IL2 IL1B IL17A
23	Human T-cell leukemia virus 1 infection ³⁶	12.38	TNF TGFB2 IL2 ICAM1
24	Metabolism of fat-soluble vitamins ⁶⁵ Show member pathways Metabolism of vitamin K ⁶⁵ Retinoid metabolism and transport ⁶⁵ The retinoid cycle in cones (daylight vision) ⁶⁵ Visual phototransduction ⁶⁵ Vitamin D (calciferol) metabolism ⁶⁵	12.37	SAG RPE65 RLBP1 RBP3
25	Tuberculosis ³⁶	12.36	TNF TGFB2 IL1B IL10 IFNG
26	C-type lectin receptor signaling pathway ³⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁴	12.27	TNF IL2 IL1B IL10
27	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.25	TNF IL4 IL1B IFNG
28	Fluid shear stress and atherosclerosis ³⁶	12.24	TNF IL1B IFNG ICAM1 CCL2
29	Yersinia infection ³⁶	12.23	TNF IL2 IL1B IL10 CCL2
30	Spinal Cord Injury ¹	12.15	TNF IL4 IL2 IL1B IFNG ICAM1
31	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	12.14	TNF IL4 IL2 IL10 IFNG
32	Osteoclast differentiation ³⁶	12.13	TNF TGFB2 IL1B IFNG
33	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	12.13	IL4 IL2 IL1B IFNG CCL3
34	Interleukin-4 and 13 signaling ⁶⁵	12.1	TNF IL4 IL1B IL17A IL10 ICAM1
35	Amoebiasis ³⁶	12.08	TNF TGFB2 IL1B IL10 IFNG
36	AGE-RAGE signaling pathway in diabetic complications ³⁶	12.07	TNF TGFB2 IL1B ICAM1 CCL2
37	TNF signaling pathway ³⁶	12.06	TNF IL1B ICAM1 CCL2
38	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	12.01	TGFB2 IL4 IL22 IL1B IL17A IFNG
39	Visual Cycle in Retinal Rods ⁶³	11.99	SAG RPE65 RLBP1 RBP3
40	Glucocorticoid receptor regulatory network ¹	11.92	IL4 IL2 IFNG ICAM1
41	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.91	TNF IL2 IL1B IL17A IL10 IFNG
42	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.9	TNF IL2 IL1B IL10 IFNG
43	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.89	TNF IL4 IL2 IFNG
44	IgA-Producing B Cells in the Intestine ⁶⁴	11.85	TNF TGFB2 IL4 IL10 ICAM1
45	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.82	TNF IL2 IL1B IFNG ICAM1
46	Lung fibrosis ¹	11.81	TNF IL4 IL1B CCL3 CCL2
47	Pertussis ³⁶	11.8	TNF IL1B IL10
48	Downstream signaling in naive CD8+ T cells ¹ Show member pathways Ras signaling in the CD4+ TCR pathway ¹	11.7	TNF IL2 IFNG
49	MSP-RON Signaling ⁶³	11.68	TNF IL1B IFNG CCL2
50	Aryl Hydrocarbon Receptor Pathway ¹	11.68	TNF IL2 IL1B IFNG

Sources

GO Terms for Autoimmune Uveitis

Cellular components related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.73	TNF TGFB2 RBP3 IL4 IL22 IL2
2	extracellular space	GO:0005615	9.44	TNF TGFB2 RBP3 IL4 IL22 IL2

Biological processes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	10.13	TNF IL4 IL1B IFNG CCL3
2	cell-cell signaling	GO:0007267	10.02	IL2 IL1B IL17A CCL3
3	inflammatory response	GO:0006954	10.02	TNF IL22 IL1B IL17A CCL3 CCL2
4	positive regulation of ERK1 and ERK2 cascade	GO:0070374	10.01	TNF ICAM1 CCL3 CCL2
5	visual perception	GO:0007601	10.01	RPE65 RLBP1 RBP3 CRYAA
6	positive regulation of protein phosphorylation	GO:0001934	10	TNF IL2 IL1B IFNG
7	MAPK cascade	GO:0000165	10	TNF IL2 IL1B CCL3 CCL2
8	neutrophil chemotaxis	GO:0030593	9.9	TGFB2 CCL3 CCL2
9	regulation of insulin secretion	GO:0050796	9.9	TNF IL1B IFNG
10	response to glucocorticoid	GO:0051384	9.89	TNF IL22 IL10
11	positive regulation of interferon-gamma production	GO:0032729	9.88	TNF IL2 IL1B
12	positive regulation of T cell proliferation	GO:0042102	9.88	IL4 IL2 IL1B
13	cellular response to lipopolysaccharide	GO:0071222	9.88	TNF IL1B IL10 ICAM1 CCL2
14	retinoid metabolic process	GO:0001523	9.87	RPE65 RLBP1 RBP3
15	positive regulation of interleukin-6 production	GO:0032755	9.87	TNF IL1B IL17A IFNG
16	humoral immune response	GO:0006959	9.86	TNF IFNG CCL2
17	positive regulation of neuron apoptotic process	GO:0043525	9.86	TNF TGFB2 CCL3
18	cellular response to interleukin-1	GO:0071347	9.86	IL17A ICAM1 CCL3 CCL2
19	positive regulation of cytokine production	GO:0001819	9.85	TNF IL10 IFNG
20	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.84	TNF IL4 IL2 IFNG
21	positive regulation of phagocytosis	GO:0050766	9.82	TNF IL1B IFNG
22	extrinsic apoptotic signaling pathway	GO:0097191	9.82	TNF TGFB2 IFNG
23	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	9.81	TNF TGFB2 IL10
24	negative regulation of endothelial cell apoptotic process	GO:2000352	9.8	IL4 IL10 ICAM1
25	cellular response to organic cyclic compound	GO:0071407	9.8	TNF IL1B CCL3 CCL2
26	microglial cell activation	GO:0001774	9.77	TNF IL4 IFNG
27	positive regulation of interleukin-1 beta production	GO:0032731	9.76	TNF IL17A IFNG CCL3
28	positive regulation of osteoclast differentiation	GO:0045672	9.75	TNF IL17A IFNG
29	negative regulation of amyloid-beta clearance	GO:1900222	9.73	TNF IFNG
30	regulation of establishment of endothelial barrier	GO:1903140	9.72	TNF IL1B
31	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.72	IL4 IL2
32	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.72	IL4 IL2
33	endothelial cell apoptotic process	GO:0072577	9.71	TNF IL10
34	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.71	TNF IL1B IFNG ICAM1
35	positive regulation of NMDA glutamate receptor activity	GO:1904783	9.7	IFNG CCL2
36	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.7	TNF IL1B IFNG
37	regulation of complement-dependent cytotoxicity	GO:1903659	9.69	TGFB2 IL10
38	vascular endothelial growth factor production	GO:0010573	9.69	TNF IL1B
39	vitamin A metabolic process	GO:0006776	9.69	RPE65 RLBP1
40	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.69	TNF IL1B IL10
41	positive regulation of mononuclear cell migration	GO:0071677	9.68	TNF IL4
42	negative regulation of cytokine production involved in immune response	GO:0002719	9.67	TNF IL10
43	positive regulation of cellular respiration	GO:1901857	9.67	IL4 IFNG
44	neuroinflammatory response	GO:0150076	9.67	IL4 IFNG
45	protein kinase B signaling	GO:0043491	9.67	TNF IL1B CCL3 CCL2
46	astrocyte cell migration	GO:0043615	9.66	CCL3 CCL2
47	type 2 immune response	GO:0042092	9.66	IL4 IL10
48	positive regulation of interleukin-23 production	GO:0032747	9.65	IL17A IFNG
49	positive regulation of fever generation	GO:0031622	9.65	TNF IL1B
50	positive regulation of inflammatory response	GO:0050729	9.65	TNF IL2 IL1B IFNG CCL3

Molecular functions related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.36	TNF TGFB2 IL4 IL22 IL2 IL1B
2	growth factor activity	GO:0008083	9.26	TGFB2 IL4 IL2 IL10
3	retinal binding	GO:0016918	9.16	RLBP1 RBP3

Sources

Sources for Autoimmune Uveitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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²⁴ GeneHancer via GeneCards

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²⁷ GEO DataSets

²⁸ GO

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³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

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³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

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⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

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⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia