MCID: ATM099
MIFTS: 45

Autoimmune Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Uveitis

MalaCards integrated aliases for Autoimmune Uveitis:

Name: Autoimmune Uveitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040088

Summaries for Autoimmune Uveitis

Disease Ontology : 12 An autoimmune disease of eyes, ear, nose and throat that is located in the uvea.

MalaCards based summary : Autoimmune Uveitis is related to vitreoretinopathy, neovascular inflammatory and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Autoimmune Uveitis is TRIB2 (Tribbles Pseudokinase 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Metformin and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include uvea, t cells and eye, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Autoimmune Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Infectious Posterior Uveitis Systemic Diseases with Anterior Uveitis
Systemic Diseases with Posterior Uveitis

Diseases related to Autoimmune Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 551)
# Related Disease Score Top Affiliating Genes
1 vitreoretinopathy, neovascular inflammatory 31.6 TGFB2 RPE65 RLBP1 CRYAA CCL2 CAPN5
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.3 IL17A IL10 IFNG
3 pertussis 30.9 TNF IL1B IL10 CCL2
4 iridocyclitis 30.9 TNF RBP3 IL17A IL10
5 allergic encephalomyelitis 30.8 CCL3 CCL2
6 panuveitis 30.5 TNF SAG RBP3 IL17A IL10
7 posterior uveitis 30.5 TNF SAG RBP3 IL4 IL2 IFNG
8 sympathetic ophthalmia 30.4 TNF RBP3 IL10 ICAM1
9 thyroiditis 30.4 TNF IL4 IL2 IL10
10 cytomegalovirus retinitis 30.3 TNF IL10 IFNG
11 macular retinal edema 30.3 TNF IL1B ICAM1 CRYAA CCL2
12 vogt-koyanagi-harada disease 30.3 IL17A IL10 IFNG
13 spondylitis 30.1 TNF IL17A IL10 IFNG
14 retinal vascular disease 30.1 TNF IL1B ICAM1 CRYAA CCL2
15 retinal vasculitis 30.1 TNF SAG RBP3 CCL2
16 retinal vein occlusion 30.1 TNF IL1B CCL2
17 choroiditis 30.0 TNF SAG RBP3 IL17A IL10 IFNG
18 vasculitis 30.0 TNF IL17A IL10 ICAM1 CCL2
19 ocular hypertension 30.0 TGFB2 RLBP1 CRYAA
20 acute cystitis 30.0 TNF IL1B IL10 CCL2
21 graft-versus-host disease 29.9 TNF IL2 IL1B IL10 IFNG
22 intestinal disease 29.9 TNF IL1B IL17A IL10
23 retinal degeneration 29.9 SAG RPE65 RLBP1 RBP3 CRYAA CAPN5
24 microvascular complications of diabetes 1 29.9 TGFB2 ICAM1 CCL2
25 reactive arthritis 29.9 TNF IL1B IL17A IL10 IFNG
26 neutropenia 29.9 TNF IL2 IL1B IL10 IFNG
27 autoimmune disease 29.8 TNF SAG RBP3 IL4 IL22 IL2
28 gastroenteritis 29.8 TNF IL4 IL1B IL10 IFNG
29 scleritis 29.8 TNF IL4 IL22 IFNG CCL2
30 sarcoidosis 1 29.7 TNF IL2 IL1B IFNG ICAM1 CCL3
31 retinal disease 29.7 SAG RPE65 RLBP1 CRYAA
32 retinal detachment 29.6 TNF TGFB2 IL10 IFNG CCL2 CAPN5
33 chorioretinitis 29.6 TNF SAG RBP3 IL2 IL17A IL10
34 juvenile rheumatoid arthritis 29.6 TNF IL2 IL1B IL10 IFNG CCL2
35 toxoplasmosis 29.5 TNF IL4 IL1B IL10 IFNG CCL3
36 allergic hypersensitivity disease 29.5 TNF IL4 IL2 IL17A IL10 IFNG
37 endophthalmitis 29.4 TNF SAG RPE65 IL1B ICAM1 CRYAA
38 uveitis 29.3 TRIB2 TNF TGFB2 SAG RBP3 IL4
39 hashimoto thyroiditis 29.2 TNF IL4 IL2 IL1B IL17A IL10
40 proteasome-associated autoinflammatory syndrome 1 29.1 TNF IL4 IL1B IL17A IL10 IFNG
41 ulcerative colitis 28.9 TNF IL4 IL22 IL2 IL1B IL17A
42 crohn's disease 28.8 TNF IL4 IL22 IL2 IL1B IL17A
43 demyelinating disease 28.5 TNF IL4 IL2 IL1B IL17A IL10
44 macular degeneration, age-related, 1 28.4 TNF TGFB2 SAG RPE65 RLBP1 RBP3
45 eye disease 27.9 TNF TGFB2 SAG RPE65 RLBP1 RBP3
46 inflammatory bowel disease 27.7 TNF TGFB2 IL4 IL22 IL2 IL1B
47 retinitis pigmentosa 27.7 TNF SAG RPE65 RLBP1 RBP3 IL4
48 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.6 IL4 IL2
49 punctate inner choroidopathy 10.6 TNF IL10
50 acute zonal occult outer retinopathy 10.6 SAG RLBP1

Graphical network of the top 20 diseases related to Autoimmune Uveitis:



Diseases related to Autoimmune Uveitis

Symptoms & Phenotypes for Autoimmune Uveitis

MGI Mouse Phenotypes related to Autoimmune Uveitis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.29 CAPN5 ICAM1 IFNG IL10 IL17A IL1B
2 homeostasis/metabolism MP:0005376 10.28 ICAM1 IFNG IL10 IL17A IL1B IL2
3 immune system MP:0005387 10.28 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
4 hematopoietic system MP:0005397 10.23 ICAM1 IFNG IL10 IL17A IL1B IL2
5 digestive/alimentary MP:0005381 10.15 ICAM1 IFNG IL10 IL17A IL2 IL22
6 craniofacial MP:0005382 10.11 IFNG IL10 IL17A IL1B IL4 RLBP1
7 integument MP:0010771 10.07 ICAM1 IFNG IL10 IL17A IL1B IL22
8 nervous system MP:0003631 10.03 ICAM1 IFNG IL10 IL1B IL4 RBP3
9 neoplasm MP:0002006 9.87 ICAM1 IFNG IL10 IL1B IL2 IL22
10 no phenotypic analysis MP:0003012 9.76 IFNG IL10 IL17A IL2 IL22 IL4
11 respiratory system MP:0005388 9.56 IFNG IL10 IL17A IL2 IL22 IL4
12 vision/eye MP:0005391 9.36 ICAM1 IFNG IL10 IL2 IL4 RBP3

Drugs & Therapeutics for Autoimmune Uveitis

Drugs for Autoimmune Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved 657-24-9 14219 4091
2
Curcumin Approved, Experimental, Investigational Early Phase 1 458-37-7 969516
3
Adalimumab Approved 331731-18-1 16219006
4
Methotrexate Approved 59-05-2, 1959-05-2 126941
5
Chlorambucil Approved 305-03-3 2708
6
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
7
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
8
Infliximab Approved 170277-31-3
9
Mycophenolic acid Approved 24280-93-1 446541
10
Azathioprine Approved 446-86-6 2265
11
Sirolimus Approved, Investigational 53123-88-9 5284616 6436030 46835353
12 Antitubercular Agents
13 Anti-Infective Agents
14 Anti-Bacterial Agents
15 Antibiotics, Antitubercular
16 glucocorticoids
17 Hypoglycemic Agents
18 Cola
19 Anti-Inflammatory Agents
20 Alkylating Agents
21 Immunosuppressive Agents
22 Immunologic Factors
23 Cyclosporins
24 Calcineurin Inhibitors
25 Antimetabolites

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mycophenolate Sodium (Myfortic®) in the Treatment of Corticosteroid-refractory Autoimmune Uveitis:Pilot Study Unknown status NCT01261169 Myfortic
2 to Investigate the Maternal Serum IL-17 Levels in Pregnant Women With Intrahepatic Cholestasis of Pregnancy Unknown status NCT01898832
3 Effect of Pregnancy on Uveitis Completed NCT00001867
4 Multicenter, Randomized, Controlled Clinical Trial Research Evaluating the Use of Combination Therapy of Glucocorticoids and Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis Recruiting NCT03525028 Metformin;Placebo
5 Immunoassay and Regulation of Traditional Chinese Medicine on Cancer Patients Recruiting NCT04438564
6 Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis: a Multicenter Randomized, Placebo Controlled, Double-blind Clinical Study Active, not recruiting NCT03584724 Early Phase 1 Norflo Oro;Placebo for Norflo Oro
7 Treatment Outcome of Uveitis in Autoimmune Diseases Not yet recruiting NCT03886233 Corticosteroid Series
8 Pilot Project: The Amplicon and Metatranscriptomic Next-generation Sequencing of Samples From Intra and Extra-intestinal Microbiome in Non-infectious Uveitis Patients to Decipher Possibility Uveitis Pathogenesis Not yet recruiting NCT04126850

Search NIH Clinical Center for Autoimmune Uveitis

Genetic Tests for Autoimmune Uveitis

Anatomical Context for Autoimmune Uveitis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Uveitis:

19
Uvea

MalaCards organs/tissues related to Autoimmune Uveitis:

40
T Cells, Eye, Retina, Pineal, Monocytes, B Cells, Spleen

Publications for Autoimmune Uveitis

Articles related to Autoimmune Uveitis:

(show top 50) (show all 846)
# Title Authors PMID Year
1
TIGIT+ A2Ar-Dependent anti-uveitic Treg cells are a novel subset of Tregs associated with resolution of autoimmune uveitis. 61
32201225 2020
2
Analysis of the role of palmitoleic acid in acute anterior uveitis. 61
32422526 2020
3
An Increase of Oxidized Phospholipids and the Role of Macrophages in Intraocular Inflammation. 61
32526032 2020
4
The relationship between TIGIT+ regulatory T cells and autoimmune disease. 61
32172208 2020
5
IL-10 and IL-17 Expression by CD4+ T Cells is Altered in Corticosteroid Refractory Immune Thrombocytopenia (ITP). 61
32574429 2020
6
A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis. 61
32569628 2020
7
Matairesinol ameliorates experimental autoimmune uveitis by suppression of IRBP-specific Th17 cells. 61
32559555 2020
8
Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice. 61
32380695 2020
9
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis. 61
32422390 2020
10
Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease. 61
31928124 2020
11
Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide. 61
32169850 2020
12
Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis. 61
32044663 2020
13
Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach. 61
32183784 2020
14
Do epigenetic changes caused by commensal microbiota contribute to development of ocular disease? A review of evidence. 61
32169120 2020
15
A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina. 61
32118582 2020
16
DAPT reverses the Th17/Treg imbalance in experimental autoimmune uveitis in vitro via inhibiting Notch signaling pathway. 61
31863921 2020
17
Therapeutic potential of aryl hydrocarbon receptor in autoimmunity. 61
31617124 2020
18
Aminooxy-acetic acid inhibits experimental autoimmune uveitis by modulating the balance between effector and regulatory lymphocyte subsets. 61
32072910 2020
19
Correction: Dendritic cells mediate the anti-inflammatory action of omega-3 long-chain polyunsaturated fatty acids in experimental autoimmune uveitis. 61
32218588 2020
20
A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis. 61
32101556 2020
21
Activated γδ T Cells Promote Dendritic Cell Maturation and Exacerbate the Development of Experimental Autoimmune Uveitis (EAU) in Mice. 61
31985304 2020
22
Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells. 61
32508841 2020
23
I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis. 61
32256194 2020
24
Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis. 61
32547555 2020
25
Aberrant Migratory Behavior of Immune Cells in Recurrent Autoimmune Uveitis in Horses. 61
32211402 2020
26
Network pharmacology-based identification of the key mechanism of Qinghuo Rougan Formula acting on uveitis. 61
31542616 2019
27
Soluble cytokine receptor levels in aqueous humour of patients with specific autoimmune uveitic entities: sCD30 is a biomarker of granulomatous uveitis. 61
31804623 2019
28
miR-223-3p promotes autoreactive Th17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression. 61
31645142 2019
29
AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis. 61
31882729 2019
30
Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis. 61
31545975 2019
31
KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis. 61
31883532 2019
32
Resolution of uveitis. 61
31591678 2019
33
Tissue-specific production of MicroRNA-155 inhibits melanocortin 5 receptor-dependent suppressor macrophages to promote experimental autoimmune uveitis. 61
31177529 2019
34
AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis. 61
31795515 2019
35
PD-1+ melanocortin receptor dependent-Treg cells prevent autoimmune disease. 61
31729418 2019
36
Exacerbation of autoimmune uveitis by obesity occurs through the melanocortin 5 receptor. 61
31287586 2019
37
The cAMP-Adenosine Feedback Loop Maintains the Suppressive Function of Regulatory T Cells. 61
31420466 2019
38
Flow Plex-A tool for unbiased comprehensive flow cytometry data analysis. 61
31016894 2019
39
Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. 61
31209505 2019
40
Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand. 61
31588375 2019
41
Immunosuppression in the Management of Presumed Non-infective Uveitis; Are We Sure What We are Treating? Notes on the Antimicrobial Properties of the Systemic Immunosuppressants. 61
31418624 2019
42
Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity. 61
31080013 2019
43
Recent advances of exosomes in immune-mediated eye diseases. 61
31470892 2019
44
Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells. 61
31291583 2019
45
AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells. 61
30853312 2019
46
Adenosine receptor activation in the Th17 autoimmune responses of experimental autoimmune uveitis. 61
30249343 2019
47
Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity. 61
30894405 2019
48
Retinal microglia initiate neuroinflammation in ocular autoimmunity. 61
31023885 2019
49
Importance of the intestinal microbiota in ocular inflammatory diseases: A review. 61
30834680 2019
50
Evaluation of controlled-release triamcinolone acetonide-loaded mPEG-PLGA nanoparticles in treating experimental autoimmune uveitis. 61
30641491 2019

Variations for Autoimmune Uveitis

Expression for Autoimmune Uveitis

Search GEO for disease gene expression data for Autoimmune Uveitis.

Pathways for Autoimmune Uveitis

Pathways related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 TNF IL4 IL22RA1 IL22 IL2 IL1B
2
Show member pathways
13.92 TNF TGFB2 IL4 IL22RA1 IL22 IL2
3
Show member pathways
13.77 TNF TGFB2 IL4 IL22RA1 IL22 IL2
4
Show member pathways
13.6 TNF TGFB2 IL4 IL22RA1 IL22 IL2
5
Show member pathways
13.5 TNF TGFB2 IL4 IL22RA1 IL22 IL2
6
Show member pathways
13.42 TNF IL4 IL22RA1 IL22 IL2 IL1B
7
Show member pathways
13.4 TNF TGFB2 IL4 IL22RA1 IL22 IL2
8
Show member pathways
13.18 TNF TGFB2 IL2 IL1B IL10 IFNG
9
Show member pathways
12.95 TNF IL4 IL22 IL2 IL1B IL17A
10
Show member pathways
12.9 TNF IL2 IL1B IFNG ICAM1 CCL2
11
Show member pathways
12.73 TNF IL4 IL2 IL1B IL17A IL10
12
Show member pathways
12.71 TNF IL2 IL1B IL17A IL10 IFNG
13
Show member pathways
12.69 TNF IL4 IL2 IL10 IFNG
14 12.62 TRIB2 TNF IL4 IL2 IL1B IL17A
15
Show member pathways
12.59 TNF IL4 IL2 IFNG ICAM1
16
Show member pathways
12.58 IL4 IL22RA1 IL22 IL2 IL10 IFNG
17
Show member pathways
12.56 TNF TGFB2 IL4 IL22RA1 IL22 IL2
18
Show member pathways
12.48 TNF IL4 IL2 IL1B IFNG ICAM1
19
Show member pathways
12.47 TNF IL4 IL1B IL17A IFNG CCL2
20
Show member pathways
12.47 TNF IL22RA1 IL2 IL10 CCL3 CCL2
21
Show member pathways
12.4 TNF TGFB2 IL4 IL1B IL10 IFNG
22
Show member pathways
12.4 TNF TGFB2 IL4 IL2 IL1B IL17A
23 12.38 TNF TGFB2 IL2 ICAM1
24
Show member pathways
12.37 SAG RPE65 RLBP1 RBP3
25 12.36 TNF TGFB2 IL1B IL10 IFNG
26
Show member pathways
12.27 TNF IL2 IL1B IL10
27
Show member pathways
12.25 TNF IL4 IL1B IFNG
28 12.24 TNF IL1B IFNG ICAM1 CCL2
29 12.16 TNF IL2 IL1B IL10 CCL2
30 12.15 TNF IL4 IL2 IL1B IFNG ICAM1
31 12.14 TNF IL4 IL2 IL10 IFNG
32 12.13 TNF TGFB2 IL1B IFNG
33
Show member pathways
12.13 IL4 IL2 IL1B IFNG CCL3
34
Show member pathways
12.1 TNF IL2 IL1B IL17A IL10 IFNG
35 12.1 TNF IL4 IL1B IL17A IL10 ICAM1
36 12.08 TNF TGFB2 IL1B IL10 IFNG
37 12.06 TNF IL1B ICAM1 CCL2
38 12.06 TNF TGFB2 IL1B ICAM1 CCL2
39
Show member pathways
12 TGFB2 IL4 IL22 IL1B IL17A IFNG
40 11.99 SAG RPE65 RLBP1 RBP3
41 11.92 IL4 IL2 IFNG ICAM1
42 11.9 TNF IL2 IL1B IL10 IFNG
43
Show member pathways
11.89 TNF IL4 IL2 IFNG
44
Show member pathways
11.82 TNF IL2 IL1B IFNG ICAM1
45 11.81 TNF IL4 IL1B CCL3 CCL2
46 11.8 TNF IL1B IL10
47
Show member pathways
11.7 TNF IL2 IFNG
48 11.68 TNF IL1B IFNG CCL2
49 11.67 TNF IL2 IL1B IFNG
50
Show member pathways
11.65 RPE65 RLBP1 RBP3

GO Terms for Autoimmune Uveitis

Cellular components related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF TGFB2 RBP3 IL4 IL22 IL2
2 extracellular space GO:0005615 9.44 TNF TGFB2 RBP3 IL4 IL22 IL2

Biological processes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.13 TNF IL4 IL1B IFNG CCL3
2 inflammatory response GO:0006954 10.06 TNF IL22 IL1B IL17A CCL3 CCL2
3 cell-cell signaling GO:0007267 10.04 IL2 IL1B IL17A CCL3
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.02 TNF ICAM1 CCL3 CCL2
5 visual perception GO:0007601 10.02 RPE65 RLBP1 RBP3 CRYAA
6 MAPK cascade GO:0000165 10.02 TNF IL2 IL1B CCL3 CCL2
7 positive regulation of protein phosphorylation GO:0001934 10 TNF IL2 IL1B IFNG
8 cellular response to lipopolysaccharide GO:0071222 9.91 TNF IL1B IL10 ICAM1 CCL2
9 regulation of insulin secretion GO:0050796 9.9 TNF IL1B IFNG
10 response to glucocorticoid GO:0051384 9.9 TNF IL22 IL10
11 positive regulation of T cell proliferation GO:0042102 9.89 IL4 IL2 IL1B
12 retinoid metabolic process GO:0001523 9.89 RPE65 RLBP1 RBP3
13 cellular response to interleukin-1 GO:0071347 9.89 IL17A ICAM1 CCL3 CCL2
14 humoral immune response GO:0006959 9.88 TNF IFNG CCL2
15 neutrophil chemotaxis GO:0030593 9.88 TGFB2 IL1B CCL3 CCL2
16 positive regulation of neuron apoptotic process GO:0043525 9.87 TNF TGFB2 CCL3
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 TNF IL4 IL2 IFNG
18 positive regulation of phagocytosis GO:0050766 9.85 TNF IL1B IFNG
19 positive regulation of interferon-gamma production GO:0032729 9.84 TNF IL2 IL1B
20 extrinsic apoptotic signaling pathway GO:0097191 9.84 TNF TGFB2 IFNG
21 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.83 TNF TGFB2 IL10
22 cellular response to organic cyclic compound GO:0071407 9.83 TNF IL1B CCL3 CCL2
23 negative regulation of endothelial cell apoptotic process GO:2000352 9.82 IL4 IL10 ICAM1
24 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.82 IL4 IL2 IL1B
25 positive regulation of cytokine secretion GO:0050715 9.8 TNF IL10 IFNG
26 microglial cell activation GO:0001774 9.8 TNF IL4 IFNG
27 positive regulation of osteoclast differentiation GO:0045672 9.77 TNF IL17A IFNG
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 TNF IL1B IFNG ICAM1
29 positive regulation of neuroinflammatory response GO:0150078 9.74 TNF IL1B
30 astrocyte activation GO:0048143 9.74 TNF IL1B IFNG
31 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.73 IL4 IL10
32 negative regulation of amyloid-beta clearance GO:1900222 9.73 TNF IFNG
33 positive regulation of isotype switching to IgG isotypes GO:0048304 9.73 IL4 IL2
34 negative regulation of T-helper 17 cell differentiation GO:2000320 9.73 IL4 IL2
35 positive regulation of interleukin-6 secretion GO:2000778 9.73 TNF IL1B IL17A IFNG
36 regulation of establishment of endothelial barrier GO:1903140 9.72 TNF IL1B
37 endothelial cell apoptotic process GO:0072577 9.72 TNF IL10
38 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 TNF IL1B IFNG
39 positive regulation of inflammatory response GO:0050729 9.72 TNF IL2 IL1B IFNG CCL3
40 positive regulation of NMDA glutamate receptor activity GO:1904783 9.71 IFNG CCL2
41 regulation of complement-dependent cytotoxicity GO:1903659 9.71 TGFB2 IL10
42 vitamin A metabolic process GO:0006776 9.71 RPE65 RLBP1
43 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 TNF IL1B IL10
44 protein kinase B signaling GO:0043491 9.71 TNF IL1B CCL3 CCL2
45 positive regulation of mononuclear cell migration GO:0071677 9.7 TNF IL4
46 astrocyte cell migration GO:0043615 9.69 CCL3 CCL2
47 type 2 immune response GO:0042092 9.69 IL4 IL10
48 negative regulation of cytokine production involved in immune response GO:0002719 9.69 TNF IL10
49 positive regulation of cellular respiration GO:1901857 9.68 IL4 IFNG
50 neuroinflammatory response GO:0150076 9.68 IL4 IFNG

Molecular functions related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TNF TGFB2 IL4 IL22 IL2 IL1B
2 growth factor activity GO:0008083 9.26 TGFB2 IL4 IL2 IL10
3 retinal binding GO:0016918 9.16 RLBP1 RBP3

Sources for Autoimmune Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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