Autoimmune Uveitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ATM099 MIFTS: 45	Autoimmune Uveitis Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Autoimmune Uveitis

MalaCards integrated aliases for Autoimmune Uveitis:

Name: Autoimmune Uveitis ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Immune diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0040088

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Summaries for Autoimmune Uveitis

Disease Ontology : ¹² An autoimmune disease of eyes, ear, nose and throat that is located in the uvea.

MalaCards based summary : Autoimmune Uveitis is related to vitreoretinopathy, neovascular inflammatory and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Autoimmune Uveitis is TRIB2 (Tribbles Pseudokinase 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Metformin and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include uvea, t cells and eye, and related phenotypes are growth/size/body region and homeostasis/metabolism

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Related Diseases for Autoimmune Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis	Posterior Uveitis
Intermediate Uveitis	Infectious Anterior Uveitis
Infectious Posterior Uveitis	Systemic Diseases with Anterior Uveitis
Systemic Diseases with Posterior Uveitis

Diseases related to Autoimmune Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 551)

#	Related Disease	Score	Top Affiliating Genes
1	vitreoretinopathy, neovascular inflammatory	31.6	TGFB2 RPE65 RLBP1 CRYAA CCL2 CAPN5
2	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	31.3	IL17A IL10 IFNG
3	pertussis	30.9	TNF IL1B IL10 CCL2
4	iridocyclitis	30.9	TNF RBP3 IL17A IL10
5	allergic encephalomyelitis	30.8	CCL3 CCL2
6	panuveitis	30.5	TNF SAG RBP3 IL17A IL10
7	posterior uveitis	30.5	TNF SAG RBP3 IL4 IL2 IFNG
8	sympathetic ophthalmia	30.4	TNF RBP3 IL10 ICAM1
9	thyroiditis	30.4	TNF IL4 IL2 IL10
10	cytomegalovirus retinitis	30.3	TNF IL10 IFNG
11	macular retinal edema	30.3	TNF IL1B ICAM1 CRYAA CCL2
12	vogt-koyanagi-harada disease	30.3	IL17A IL10 IFNG
13	spondylitis	30.1	TNF IL17A IL10 IFNG
14	retinal vascular disease	30.1	TNF IL1B ICAM1 CRYAA CCL2
15	retinal vasculitis	30.1	TNF SAG RBP3 CCL2
16	retinal vein occlusion	30.1	TNF IL1B CCL2
17	choroiditis	30.0	TNF SAG RBP3 IL17A IL10 IFNG
18	vasculitis	30.0	TNF IL17A IL10 ICAM1 CCL2
19	ocular hypertension	30.0	TGFB2 RLBP1 CRYAA
20	acute cystitis	30.0	TNF IL1B IL10 CCL2
21	graft-versus-host disease	29.9	TNF IL2 IL1B IL10 IFNG
22	intestinal disease	29.9	TNF IL1B IL17A IL10
23	retinal degeneration	29.9	SAG RPE65 RLBP1 RBP3 CRYAA CAPN5
24	microvascular complications of diabetes 1	29.9	TGFB2 ICAM1 CCL2
25	reactive arthritis	29.9	TNF IL1B IL17A IL10 IFNG
26	neutropenia	29.9	TNF IL2 IL1B IL10 IFNG
27	autoimmune disease	29.8	TNF SAG RBP3 IL4 IL22 IL2
28	gastroenteritis	29.8	TNF IL4 IL1B IL10 IFNG
29	scleritis	29.8	TNF IL4 IL22 IFNG CCL2
30	sarcoidosis 1	29.7	TNF IL2 IL1B IFNG ICAM1 CCL3
31	retinal disease	29.7	SAG RPE65 RLBP1 CRYAA
32	retinal detachment	29.6	TNF TGFB2 IL10 IFNG CCL2 CAPN5
33	chorioretinitis	29.6	TNF SAG RBP3 IL2 IL17A IL10
34	juvenile rheumatoid arthritis	29.6	TNF IL2 IL1B IL10 IFNG CCL2
35	toxoplasmosis	29.5	TNF IL4 IL1B IL10 IFNG CCL3
36	allergic hypersensitivity disease	29.5	TNF IL4 IL2 IL17A IL10 IFNG
37	endophthalmitis	29.4	TNF SAG RPE65 IL1B ICAM1 CRYAA
38	uveitis	29.3	TRIB2 TNF TGFB2 SAG RBP3 IL4
39	hashimoto thyroiditis	29.2	TNF IL4 IL2 IL1B IL17A IL10
40	proteasome-associated autoinflammatory syndrome 1	29.1	TNF IL4 IL1B IL17A IL10 IFNG
41	ulcerative colitis	28.9	TNF IL4 IL22 IL2 IL1B IL17A
42	crohn's disease	28.8	TNF IL4 IL22 IL2 IL1B IL17A
43	demyelinating disease	28.5	TNF IL4 IL2 IL1B IL17A IL10
44	macular degeneration, age-related, 1	28.4	TNF TGFB2 SAG RPE65 RLBP1 RBP3
45	eye disease	27.9	TNF TGFB2 SAG RPE65 RLBP1 RBP3
46	inflammatory bowel disease	27.7	TNF TGFB2 IL4 IL22 IL2 IL1B
47	retinitis pigmentosa	27.7	TNF SAG RPE65 RLBP1 RBP3 IL4
48	1-chloro-2,4-dinitrobenzene allergic contact dermatitis	10.6	IL4 IL2
49	punctate inner choroidopathy	10.6	TNF IL10
50	acute zonal occult outer retinopathy	10.6	SAG RLBP1

Graphical network of the top 20 diseases related to Autoimmune Uveitis:

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Symptoms & Phenotypes for Autoimmune Uveitis

MGI Mouse Phenotypes related to Autoimmune Uveitis:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.29	CAPN5 ICAM1 IFNG IL10 IL17A IL1B
2	homeostasis/metabolism	MP:0005376	10.28	ICAM1 IFNG IL10 IL17A IL1B IL2
3	immune system	MP:0005387	10.28	CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
4	hematopoietic system	MP:0005397	10.23	ICAM1 IFNG IL10 IL17A IL1B IL2
5	digestive/alimentary	MP:0005381	10.15	ICAM1 IFNG IL10 IL17A IL2 IL22
6	craniofacial	MP:0005382	10.11	IFNG IL10 IL17A IL1B IL4 RLBP1
7	integument	MP:0010771	10.07	ICAM1 IFNG IL10 IL17A IL1B IL22
8	nervous system	MP:0003631	10.03	ICAM1 IFNG IL10 IL1B IL4 RBP3
9	neoplasm	MP:0002006	9.87	ICAM1 IFNG IL10 IL1B IL2 IL22
10	no phenotypic analysis	MP:0003012	9.76	IFNG IL10 IL17A IL2 IL22 IL4
11	respiratory system	MP:0005388	9.56	IFNG IL10 IL17A IL2 IL22 IL4
12	vision/eye	MP:0005391	9.36	ICAM1 IFNG IL10 IL2 IL4 RBP3

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Drugs & Therapeutics for Autoimmune Uveitis

Drugs for Autoimmune Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Metformin

Approved

657-24-9

14219 4091

Curcumin

Approved, Experimental, Investigational

Early Phase 1

458-37-7

969516

Adalimumab

Approved

331731-18-1

16219006

Methotrexate

Approved

59-05-2, 1959-05-2

126941

Chlorambucil

Approved

305-03-3

2708

Tacrolimus

Approved, Investigational

104987-11-3

445643 439492 6473866

Cyclophosphamide

Approved, Investigational

50-18-0, 6055-19-2

2907

Infliximab

Approved

170277-31-3

Mycophenolic acid

Approved

24280-93-1

446541

Azathioprine

Approved

446-86-6

2265

Sirolimus

Approved, Investigational

53123-88-9

5284616 6436030 46835353

Antitubercular Agents

Anti-Infective Agents

Anti-Bacterial Agents

Antibiotics, Antitubercular

glucocorticoids

Hypoglycemic Agents

Cola

Anti-Inflammatory Agents

Alkylating Agents

Immunosuppressive Agents

Immunologic Factors

Cyclosporins

Calcineurin Inhibitors

Antimetabolites

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Mycophenolate Sodium (Myfortic®) in the Treatment of Corticosteroid-refractory Autoimmune Uveitis:Pilot Study	Unknown status	NCT01261169		Myfortic
2	to Investigate the Maternal Serum IL-17 Levels in Pregnant Women With Intrahepatic Cholestasis of Pregnancy	Unknown status	NCT01898832
3	Effect of Pregnancy on Uveitis	Completed	NCT00001867
4	Multicenter, Randomized, Controlled Clinical Trial Research Evaluating the Use of Combination Therapy of Glucocorticoids and Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis	Recruiting	NCT03525028		Metformin;Placebo
5	Immunoassay and Regulation of Traditional Chinese Medicine on Cancer Patients	Recruiting	NCT04438564
6	Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis: a Multicenter Randomized, Placebo Controlled, Double-blind Clinical Study	Active, not recruiting	NCT03584724	Early Phase 1	Norflo Oro;Placebo for Norflo Oro
7	Treatment Outcome of Uveitis in Autoimmune Diseases	Not yet recruiting	NCT03886233		Corticosteroid Series
8	Pilot Project: The Amplicon and Metatranscriptomic Next-generation Sequencing of Samples From Intra and Extra-intestinal Microbiome in Non-infectious Uveitis Patients to Decipher Possibility Uveitis Pathogenesis	Not yet recruiting	NCT04126850

Search NIH Clinical Center for Autoimmune Uveitis

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Genetic Tests for Autoimmune Uveitis

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Anatomical Context for Autoimmune Uveitis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Uveitis:

¹⁹

Uvea

MalaCards organs/tissues related to Autoimmune Uveitis:

⁴⁰

T Cells, Eye, Retina, Pineal, Monocytes, B Cells, Spleen

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Publications for Autoimmune Uveitis

Articles related to Autoimmune Uveitis:

(show top 50) (show all 846)

#	Title	Authors	PMID	Year
1	TIGIT+ A2Ar-Dependent anti-uveitic Treg cells are a novel subset of Tregs associated with resolution of autoimmune uveitis. ⁶¹	Muhammad F...Lee DJ	32201225	2020
2	Analysis of the role of palmitoleic acid in acute anterior uveitis. ⁶¹	Huang X...Yang P	32422526	2020
3	An Increase of Oxidized Phospholipids and the Role of Macrophages in Intraocular Inflammation. ⁶¹	Hiraoka M...Abe A	32526032	2020
4	The relationship between TIGIT+ regulatory T cells and autoimmune disease. ⁶¹	Lee DJ	32172208	2020
5	IL-10 and IL-17 Expression by CD4+ T Cells is Altered in Corticosteroid Refractory Immune Thrombocytopenia (ITP). ⁶¹	Stimpson ML...Bradbury CA	32574429	2020
6	A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis. ⁶¹	Zhou J...Li X	32569628	2020
7	Matairesinol ameliorates experimental autoimmune uveitis by suppression of IRBP-specific Th17 cells. ⁶¹	Li X...Mu H	32559555	2020
8	Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice. ⁶¹	Hsu SM...Chen SH	32380695	2020
9	Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis. ⁶¹	Zhong Z...Yang P	32422390	2020
10	Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease. ⁶¹	Ye Z...Yang P	31928124	2020
11	Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide. ⁶¹	He X...Ruan Q	32169850	2020
12	Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis. ⁶¹	Du Z...Yang P	32044663	2020
13	Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach. ⁶¹	Lipski DA...Willermain F	32183784	2020
14	Do epigenetic changes caused by commensal microbiota contribute to development of ocular disease? A review of evidence. ⁶¹	Nayyar A...Danias J	32169120	2020
15	A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina. ⁶¹	Wei J...Caspi RR	32118582	2020
16	DAPT reverses the Th17/Treg imbalance in experimental autoimmune uveitis in vitro via inhibiting Notch signaling pathway. ⁶¹	Yin X...Guo D	31863921	2020
17	Therapeutic potential of aryl hydrocarbon receptor in autoimmunity. ⁶¹	Wang XS...Pan HF	31617124	2020
18	Aminooxy-acetic acid inhibits experimental autoimmune uveitis by modulating the balance between effector and regulatory lymphocyte subsets. ⁶¹	Mei S...Hou S	32072910	2020
19	Correction: Dendritic cells mediate the anti-inflammatory action of omega-3 long-chain polyunsaturated fatty acids in experimental autoimmune uveitis. ⁶¹	Uchi SH...Kimura K	32218588	2020
20	A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis. ⁶¹	Ahmed CM...Lewin AS	32101556	2020
21	Activated γδ T Cells Promote Dendritic Cell Maturation and Exacerbate the Development of Experimental Autoimmune Uveitis (EAU) in Mice. ⁶¹	Wang B...Bi H	31985304	2020
22	Kallistatin Attenuates Experimental Autoimmune Uveitis by Inhibiting Activation of T Cells. ⁶¹	Muhammad F...Lee DJ	32508841	2020
23	I-alowCD11bhigh DC Regulates the Immune Response in the Eyes of Experimental Autoimmune Uveitis. ⁶¹	Zhao Y...Lin W	32256194	2020
24	Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis. ⁶¹	Kang M...Egwuagu CE	32547555	2020
25	Aberrant Migratory Behavior of Immune Cells in Recurrent Autoimmune Uveitis in Horses. ⁶¹	Wiedemann C...Deeg CA	32211402	2020
26	Network pharmacology-based identification of the key mechanism of Qinghuo Rougan Formula acting on uveitis. ⁶¹	Jing C...Bi H	31542616	2019
27	Soluble cytokine receptor levels in aqueous humour of patients with specific autoimmune uveitic entities: sCD30 is a biomarker of granulomatous uveitis. ⁶¹	Abu El-Asrar AM...Struyf S	31804623	2019
28	miR-223-3p promotes autoreactive Th17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression. ⁶¹	Wei Y...Nian H	31645142	2019
29	AAV-mediated expression of HLA-G1/5 reduces severity of experimental autoimmune uveitis. ⁶¹	Crabtree E...Gilger BC	31882729	2019
30	Teriflunomide suppresses T helper cells and dendritic cells to alleviate experimental autoimmune uveitis. ⁶¹	Li Z...Liang D	31545975	2019
31	KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis. ⁶¹	Niu T...Xu X	31883532	2019
32	Resolution of uveitis. ⁶¹	Wildner G...Diedrichs-Mohring M	31591678	2019
33	Tissue-specific production of MicroRNA-155 inhibits melanocortin 5 receptor-dependent suppressor macrophages to promote experimental autoimmune uveitis. ⁶¹	Muhammad F...Lee DJ	31177529	2019
34	AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis. ⁶¹	Ridley RB...Ildefonso CJ	31795515	2019
35	PD-1+ melanocortin receptor dependent-Treg cells prevent autoimmune disease. ⁶¹	Muhammad F...Lee DJ	31729418	2019
36	Exacerbation of autoimmune uveitis by obesity occurs through the melanocortin 5 receptor. ⁶¹	Muhammad FY...Lee DJ	31287586	2019
37	The cAMP-Adenosine Feedback Loop Maintains the Suppressive Function of Regulatory T Cells. ⁶¹	Su W...Zheng SG	31420466	2019
38	Flow Plex-A tool for unbiased comprehensive flow cytometry data analysis. ⁶¹	Nowatzky J...Manches O	31016894	2019
39	Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. ⁶¹	Yin X...Guo D	31209505	2019
40	Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand. ⁶¹	Pepple KL...Porter A	31588375	2019
41	Immunosuppression in the Management of Presumed Non-infective Uveitis; Are We Sure What We are Treating? Notes on the Antimicrobial Properties of the Systemic Immunosuppressants. ⁶¹	Jones NP	31418624	2019
42	Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity. ⁶¹	Mattapallil MJ...Caspi RR	31080013	2019
43	Recent advances of exosomes in immune-mediated eye diseases. ⁶¹	Li N...Wei R	31470892	2019
44	Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells. ⁶¹	Wang W...Chen J	31291583	2019
45	AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells. ⁶¹	Bing SJ...Caspi RR	30853312	2019
46	Adenosine receptor activation in the Th17 autoimmune responses of experimental autoimmune uveitis. ⁶¹	Li X...Sun D	30249343	2019
47	Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity. ⁶¹	Raverdeau M...Mills KH	30894405	2019
48	Retinal microglia initiate neuroinflammation in ocular autoimmunity. ⁶¹	Okunuki Y...Connor KM	31023885	2019
49	Importance of the intestinal microbiota in ocular inflammatory diseases: A review. ⁶¹	Lin P	30834680	2019
50	Evaluation of controlled-release triamcinolone acetonide-loaded mPEG-PLGA nanoparticles in treating experimental autoimmune uveitis. ⁶¹	Guo D...Bi H	30641491	2019

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Genes for Autoimmune Uveitis

Genes related to Autoimmune Uveitis (0 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TRIB2	Tribbles Pseudokinase 2	Protein Coding	20.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Proteins (show sections)
2	RBP3	Retinol Binding Protein 3	Protein Coding	17.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	SAG	S-Antigen Visual Arrestin	Protein Coding	15.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CRYAA	Crystallin Alpha A	Protein Coding	14.38	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL17A	Interleukin 17A	Protein Coding	13.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL10	Interleukin 10	Protein Coding	13.26	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL2	Interleukin 2	Protein Coding	13.1	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TNF	Tumor Necrosis Factor	Protein Coding	12.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL4	Interleukin 4	Protein Coding	12.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	IL1B	Interleukin 1 Beta	Protein Coding	12.46	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IL22	Interleukin 22	Protein Coding	12.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	RLBP1	Retinaldehyde Binding Protein 1	Protein Coding	12.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	12.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	12.24	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	IFNG	Interferon Gamma	Protein Coding	12.12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	CAPN5	Calpain 5	Protein Coding	11.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	11.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	11.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	IL22RA1	Interleukin 22 Receptor Subunit Alpha 1	Protein Coding	11.39	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	RPE65	Retinoid Isomerohydrolase RPE65	Protein Coding	11.37	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	11.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	IFNA1	Interferon Alpha 1	Protein Coding	11.27	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	11.18	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	11.13	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Autoimmune Uveitis

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Expression for Autoimmune Uveitis

Search GEO for disease gene expression data for Autoimmune Uveitis.

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Pathways for Autoimmune Uveitis

Pathways related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.1	TNF IL4 IL22RA1 IL22 IL2 IL1B
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.92	TNF TGFB2 IL4 IL22RA1 IL22 IL2
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.77	TNF TGFB2 IL4 IL22RA1 IL22 IL2
4	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.6	TNF TGFB2 IL4 IL22RA1 IL22 IL2
5	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.5	TNF TGFB2 IL4 IL22RA1 IL22 IL2
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.42	TNF IL4 IL22RA1 IL22 IL2 IL1B
7	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.4	TNF TGFB2 IL4 IL22RA1 IL22 IL2
8	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.18	TNF TGFB2 IL2 IL1B IL10 IFNG
9	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.95	TNF IL4 IL22 IL2 IL1B IL17A
10	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.9	TNF IL2 IL1B IFNG ICAM1 CCL2
11	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.73	TNF IL4 IL2 IL1B IL17A IL10
12	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.71	TNF IL2 IL1B IL17A IL10 IFNG
13	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.69	TNF IL4 IL2 IL10 IFNG
14	NF-kappaB Signaling ⁴	12.62	TRIB2 TNF IL4 IL2 IL1B IL17A
15	Immune response Role of DAP12 receptors in NK cells ²² Show member pathways Immune response CD16 signaling in NK cells ²² Natural killer cell mediated cytotoxicity ³⁶	12.59	TNF IL4 IL2 IFNG ICAM1
16	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.58	IL4 IL22RA1 IL22 IL2 IL10 IFNG
17	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.56	TNF TGFB2 IL4 IL22RA1 IL22 IL2
18	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.48	TNF IL4 IL2 IL1B IFNG ICAM1
19	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.47	TNF IL4 IL1B IL17A IFNG CCL2
20	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.47	TNF IL22RA1 IL2 IL10 CCL3 CCL2
21	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.4	TNF TGFB2 IL4 IL1B IL10 IFNG
22	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.4	TNF TGFB2 IL4 IL2 IL1B IL17A
23	Human T-cell leukemia virus 1 infection ³⁶	12.38	TNF TGFB2 IL2 ICAM1
24	Metabolism of fat-soluble vitamins ⁶⁵ Show member pathways Metabolism of vitamin K ⁶⁵ Retinoid metabolism and transport ⁶⁵ The retinoid cycle in cones (daylight vision) ⁶⁵ Visual phototransduction ⁶⁵ Vitamin D (calciferol) metabolism ⁶⁵	12.37	SAG RPE65 RLBP1 RBP3
25	Tuberculosis ³⁶	12.36	TNF TGFB2 IL1B IL10 IFNG
26	C-type lectin receptor signaling pathway ³⁶ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁴	12.27	TNF IL2 IL1B IL10
27	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.25	TNF IL4 IL1B IFNG
28	Fluid shear stress and atherosclerosis ³⁶	12.24	TNF IL1B IFNG ICAM1 CCL2
29	Yersinia infection ³⁶	12.16	TNF IL2 IL1B IL10 CCL2
30	Spinal Cord Injury ¹	12.15	TNF IL4 IL2 IL1B IFNG ICAM1
31	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	12.14	TNF IL4 IL2 IL10 IFNG
32	Osteoclast differentiation ³⁶	12.13	TNF TGFB2 IL1B IFNG
33	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	12.13	IL4 IL2 IL1B IFNG CCL3
34	IL27-mediated signaling events ¹ Show member pathways IL12 Signaling Pathway ⁶⁶ Th1 Differentiation ⁶⁴	12.1	TNF IL2 IL1B IL17A IL10 IFNG
35	Interleukin-4 and 13 signaling ⁶⁵	12.1	TNF IL4 IL1B IL17A IL10 ICAM1
36	Amoebiasis ³⁶	12.08	TNF TGFB2 IL1B IL10 IFNG
37	TNF signaling pathway ³⁶	12.06	TNF IL1B ICAM1 CCL2
38	AGE-RAGE signaling pathway in diabetic complications ³⁶	12.06	TNF TGFB2 IL1B ICAM1 CCL2
39	Th17 Differentiation ⁶⁴ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	12	TGFB2 IL4 IL22 IL1B IL17A IFNG
40	Visual Cycle in Retinal Rods ⁶³	11.99	SAG RPE65 RLBP1 RBP3
41	Glucocorticoid receptor regulatory network ¹	11.92	IL4 IL2 IFNG ICAM1
42	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.9	TNF IL2 IL1B IL10 IFNG
43	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.89	TNF IL4 IL2 IFNG
44	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.82	TNF IL2 IL1B IFNG ICAM1
45	Lung fibrosis ¹	11.81	TNF IL4 IL1B CCL3 CCL2
46	Pertussis ³⁶	11.8	TNF IL1B IL10
47	Downstream signaling in naive CD8+ T cells ¹ Show member pathways Ras signaling in the CD4+ TCR pathway ¹	11.7	TNF IL2 IFNG
48	MSP-RON Signaling ⁶³	11.68	TNF IL1B IFNG CCL2
49	Aryl Hydrocarbon Receptor Pathway ¹	11.67	TNF IL2 IL1B IFNG
50	the visual cycle I (vertebrates) ¹ Show member pathways retinol biosynthesis ¹ The canonical retinoid cycle in rods (twilight vision) ⁶⁵	11.65	RPE65 RLBP1 RBP3

Sources

GO Terms for Autoimmune Uveitis

Cellular components related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.73	TNF TGFB2 RBP3 IL4 IL22 IL2
2	extracellular space	GO:0005615	9.44	TNF TGFB2 RBP3 IL4 IL22 IL2

Biological processes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	10.13	TNF IL4 IL1B IFNG CCL3
2	inflammatory response	GO:0006954	10.06	TNF IL22 IL1B IL17A CCL3 CCL2
3	cell-cell signaling	GO:0007267	10.04	IL2 IL1B IL17A CCL3
4	positive regulation of ERK1 and ERK2 cascade	GO:0070374	10.02	TNF ICAM1 CCL3 CCL2
5	visual perception	GO:0007601	10.02	RPE65 RLBP1 RBP3 CRYAA
6	MAPK cascade	GO:0000165	10.02	TNF IL2 IL1B CCL3 CCL2
7	positive regulation of protein phosphorylation	GO:0001934	10	TNF IL2 IL1B IFNG
8	cellular response to lipopolysaccharide	GO:0071222	9.91	TNF IL1B IL10 ICAM1 CCL2
9	regulation of insulin secretion	GO:0050796	9.9	TNF IL1B IFNG
10	response to glucocorticoid	GO:0051384	9.9	TNF IL22 IL10
11	positive regulation of T cell proliferation	GO:0042102	9.89	IL4 IL2 IL1B
12	retinoid metabolic process	GO:0001523	9.89	RPE65 RLBP1 RBP3
13	cellular response to interleukin-1	GO:0071347	9.89	IL17A ICAM1 CCL3 CCL2
14	humoral immune response	GO:0006959	9.88	TNF IFNG CCL2
15	neutrophil chemotaxis	GO:0030593	9.88	TGFB2 IL1B CCL3 CCL2
16	positive regulation of neuron apoptotic process	GO:0043525	9.87	TNF TGFB2 CCL3
17	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.86	TNF IL4 IL2 IFNG
18	positive regulation of phagocytosis	GO:0050766	9.85	TNF IL1B IFNG
19	positive regulation of interferon-gamma production	GO:0032729	9.84	TNF IL2 IL1B
20	extrinsic apoptotic signaling pathway	GO:0097191	9.84	TNF TGFB2 IFNG
21	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	9.83	TNF TGFB2 IL10
22	cellular response to organic cyclic compound	GO:0071407	9.83	TNF IL1B CCL3 CCL2
23	negative regulation of endothelial cell apoptotic process	GO:2000352	9.82	IL4 IL10 ICAM1
24	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.82	IL4 IL2 IL1B
25	positive regulation of cytokine secretion	GO:0050715	9.8	TNF IL10 IFNG
26	microglial cell activation	GO:0001774	9.8	TNF IL4 IFNG
27	positive regulation of osteoclast differentiation	GO:0045672	9.77	TNF IL17A IFNG
28	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.76	TNF IL1B IFNG ICAM1
29	positive regulation of neuroinflammatory response	GO:0150078	9.74	TNF IL1B
30	astrocyte activation	GO:0048143	9.74	TNF IL1B IFNG
31	negative regulation of tumor necrosis factor biosynthetic process	GO:0042536	9.73	IL4 IL10
32	negative regulation of amyloid-beta clearance	GO:1900222	9.73	TNF IFNG
33	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.73	IL4 IL2
34	negative regulation of T-helper 17 cell differentiation	GO:2000320	9.73	IL4 IL2
35	positive regulation of interleukin-6 secretion	GO:2000778	9.73	TNF IL1B IL17A IFNG
36	regulation of establishment of endothelial barrier	GO:1903140	9.72	TNF IL1B
37	endothelial cell apoptotic process	GO:0072577	9.72	TNF IL10
38	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.72	TNF IL1B IFNG
39	positive regulation of inflammatory response	GO:0050729	9.72	TNF IL2 IL1B IFNG CCL3
40	positive regulation of NMDA glutamate receptor activity	GO:1904783	9.71	IFNG CCL2
41	regulation of complement-dependent cytotoxicity	GO:1903659	9.71	TGFB2 IL10
42	vitamin A metabolic process	GO:0006776	9.71	RPE65 RLBP1
43	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.71	TNF IL1B IL10
44	protein kinase B signaling	GO:0043491	9.71	TNF IL1B CCL3 CCL2
45	positive regulation of mononuclear cell migration	GO:0071677	9.7	TNF IL4
46	astrocyte cell migration	GO:0043615	9.69	CCL3 CCL2
47	type 2 immune response	GO:0042092	9.69	IL4 IL10
48	negative regulation of cytokine production involved in immune response	GO:0002719	9.69	TNF IL10
49	positive regulation of cellular respiration	GO:1901857	9.68	IL4 IFNG
50	neuroinflammatory response	GO:0150076	9.68	IL4 IFNG

Molecular functions related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.36	TNF TGFB2 IL4 IL22 IL2 IL1B
2	growth factor activity	GO:0008083	9.26	TGFB2 IL4 IL2 IL10
3	retinal binding	GO:0016918	9.16	RLBP1 RBP3

Sources

Sources for Autoimmune Uveitis

¹ BioSystems

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⁷⁴ Wikipedia