MCID: ATM099
MIFTS: 45

Autoimmune Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Uveitis

MalaCards integrated aliases for Autoimmune Uveitis:

Name: Autoimmune Uveitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040088

Summaries for Autoimmune Uveitis

Disease Ontology : 12 An autoimmune disease of eyes, ear, nose and throat that is located in the uvea.

MalaCards based summary : Autoimmune Uveitis is related to vitreoretinopathy, neovascular inflammatory and alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity. An important gene associated with Autoimmune Uveitis is TRIB2 (Tribbles Pseudokinase 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Metformin and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include uvea, t cells and eye, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Autoimmune Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Infectious Posterior Uveitis Systemic Diseases with Anterior Uveitis
Systemic Diseases with Posterior Uveitis

Diseases related to Autoimmune Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 585)
# Related Disease Score Top Affiliating Genes
1 vitreoretinopathy, neovascular inflammatory 31.2 TGFB2 RPE65 RLBP1 CRYAA CCL2 CAPN5
2 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.1 IL17A IL10 IFNG
3 pertussis 30.8 TNF IL1B IL10 CCL2
4 allergic encephalomyelitis 30.7 CCL3 CCL2
5 posterior uveitis 30.7 TNF SAG RBP3 IL4 IL2 IFNG
6 neuroretinitis 30.7 SAG CAPN5
7 iridocyclitis 30.5 TNF RBP3 IL1B IL17A IL10
8 panuveitis 30.4 TNF SAG RBP3 IL17A IL10
9 vasculitis 30.4 TNF IL17A ICAM1 CCL2
10 sympathetic ophthalmia 30.4 TNF RBP3 IL10 ICAM1
11 retinal degeneration 30.3 SAG RPE65 RLBP1 RBP3 CAPN5
12 macular retinal edema 30.2 TNF IL1B ICAM1 CRYAA CCL2
13 cytomegalovirus retinitis 30.2 TNF IL10 IFNG
14 retinal detachment 30.1 TNF IL10 IFNG CCL2 CAPN5
15 choroiditis 30.1 TNF SAG RBP3 IL17A IL10 IFNG
16 vogt-koyanagi-harada disease 30.1 IL17A IL10 IFNG
17 retinal vascular disease 30.1 TNF IL1B ICAM1 CRYAA CCL2
18 retinal vasculitis 30.0 TNF SAG RBP3 CCL2
19 ocular hypertension 30.0 TGFB2 RLBP1 CRYAA
20 retinal vein occlusion 30.0 TNF IL1B CCL2
21 uveitis 29.9 TRIB2 TNF TGFB2 SAG RBP3 IL4
22 allergic disease 29.9 TNF TGFB2 IL4 IL2 IL1B IFNG
23 cholera 29.8 TNF IL4 IL1B IL10
24 endophthalmitis 29.8 TNF SAG IL1B ICAM1 CRYAA
25 hashimoto thyroiditis 29.8 IL4 IL17A IL10 IFNG ICAM1
26 graft-versus-host disease 29.8 TNF IL2 IL1B IL10 IFNG
27 microvascular complications of diabetes 1 29.8 TGFB2 ICAM1 CRYAA CCL2
28 spondylitis 29.8 TNF IL1B IL17A IL10 IFNG
29 reactive arthritis 29.8 TNF IL1B IL17A IL10 IFNG
30 sarcoidosis 1 29.8 TNF IL2 IL1B IFNG ICAM1 CCL3
31 gastroenteritis 29.8 TNF IL4 IL1B IL10 IFNG
32 retinal disease 29.8 SAG RPE65 RLBP1 CRYAA
33 scleritis 29.7 TNF IL4 IL22 IFNG CCL2
34 thyroiditis 29.7 TNF IL4 IL2 IL1B IL17A IL10
35 autoimmune disease 29.6 TNF SAG RBP3 IL4 IL22 IL2
36 neutropenia 29.6 TNF IL4 IL2 IL1B IL10 IFNG
37 juvenile rheumatoid arthritis 29.6 TNF IL2 IL1B IL10 IFNG CCL2
38 toxoplasmosis 29.5 TNF IL4 IL1B IL10 IFNG CCL3
39 chorioretinitis 29.4 TNF SAG RBP3 IL2 IL1B IL17A
40 proteasome-associated autoinflammatory syndrome 1 29.2 TNF IL4 IL1B IL17A IL10 IFNG
41 body mass index quantitative trait locus 11 29.1 TNF IL4 IL1B IL17A IL10 ICAM1
42 ulcerative colitis 29.0 TNF IL4 IL22 IL2 IL1B IL17A
43 eye disease 28.9 TNF TGFB2 SAG RPE65 RBP3 IL4
44 crohn's disease 28.8 TNF IL4 IL22 IL2 IL1B IL17A
45 demyelinating disease 28.7 TNF IL4 IL2 IL1B IL17A IL10
46 macular degeneration, age-related, 1 28.6 TNF TGFB2 SAG RPE65 RLBP1 RBP3
47 inflammatory bowel disease 28.5 TNF IL4 IL22 IL2 IL1B IL17A
48 retinitis pigmentosa 28.3 TNF SAG RPE65 RLBP1 RBP3 IL4
49 yemenite deaf-blind hypopigmentation syndrome 10.6
50 acute zonal occult outer retinopathy 10.5 SAG RLBP1

Graphical network of the top 20 diseases related to Autoimmune Uveitis:



Diseases related to Autoimmune Uveitis

Symptoms & Phenotypes for Autoimmune Uveitis

MGI Mouse Phenotypes related to Autoimmune Uveitis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.32 CAPN5 ICAM1 IFNG IL10 IL17A IL1B
2 homeostasis/metabolism MP:0005376 10.31 ICAM1 IFNG IL10 IL17A IL1B IL2
3 immune system MP:0005387 10.28 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
4 hematopoietic system MP:0005397 10.23 ICAM1 IFNG IL10 IL17A IL1B IL2
5 craniofacial MP:0005382 10.16 IFNG IL10 IL17A IL1B IL4 RLBP1
6 digestive/alimentary MP:0005381 10.15 ICAM1 IFNG IL10 IL17A IL2 IL22
7 integument MP:0010771 10.07 ICAM1 IFNG IL10 IL17A IL1B IL22
8 nervous system MP:0003631 10.03 ICAM1 IFNG IL10 IL1B IL4 RBP3
9 neoplasm MP:0002006 9.87 ICAM1 IFNG IL10 IL1B IL2 IL22
10 no phenotypic analysis MP:0003012 9.76 IFNG IL10 IL17A IL2 IL22 IL4
11 respiratory system MP:0005388 9.56 IFNG IL10 IL17A IL2 IL22 IL4
12 vision/eye MP:0005391 9.4 ICAM1 IFNG IL10 IL2 IL4 RBP3

Drugs & Therapeutics for Autoimmune Uveitis

Drugs for Autoimmune Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved 657-24-9 14219 4091
2
Curcumin Approved, Experimental, Investigational Early Phase 1 458-37-7 969516
3
Methotrexate Approved 1959-05-2, 59-05-2 126941
4
Adalimumab Approved, Experimental 331731-18-1 16219006
5
Mycophenolic acid Approved 24280-93-1 446541
6
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
7
Sirolimus Approved, Investigational 53123-88-9 5284616 6436030
8
Chlorambucil Approved 305-03-3 2708
9
Azathioprine Approved 446-86-6 2265
10
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
11
Infliximab Approved 170277-31-3
12 Hypoglycemic Agents
13 glucocorticoids
14 Anti-Inflammatory Agents
15 Immunologic Factors
16 Antimetabolites
17 Immunosuppressive Agents
18 Cyclosporins
19 Alkylating Agents
20 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter, Randomized, Controlled Clinical Trial Research Evaluating the Use of Combination Therapy of Glucocorticoids and Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis Recruiting NCT03525028 Metformin;Placebo
2 Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis: a Multicenter Randomized, Placebo Controlled, Double-blind Clinical Study Active, not recruiting NCT03584724 Early Phase 1 Norflo Oro;Placebo for Norflo Oro
3 Pilot Project: The Amplicon and Metatranscriptomic Next-generation Sequencing of Samples From Intra and Extra-intestinal Microbiome in Non-infectious Uveitis Patients to Decipher Possibility Uveitis Pathogenesis Not yet recruiting NCT04126850
4 Treatment Outcome of Uveitis in Autoimmune Diseases Not yet recruiting NCT03886233 Corticosteroid Series

Search NIH Clinical Center for Autoimmune Uveitis

Genetic Tests for Autoimmune Uveitis

Anatomical Context for Autoimmune Uveitis

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Uveitis:

19
Uvea

MalaCards organs/tissues related to Autoimmune Uveitis:

40
T Cells, Eye, Retina, B Cells, Spleen, Monocytes, Endothelial

Publications for Autoimmune Uveitis

Articles related to Autoimmune Uveitis:

(show top 50) (show all 879)
# Title Authors PMID Year
1
Characterization of Clinical and Immune Responses in an Experimental Chronic Autoimmune Uveitis Model. 61
32966818 2021
2
Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis. 61
33602234 2021
3
Leukotriene B4 and Its Receptor in Experimental Autoimmune Uveitis and in Human Retinal Tissues: Clinical Severity and LTB4 Dependence of Retinal Th17 Cells. 61
33159884 2021
4
Activated γδ T Cells Promote Dendritic Cell Maturation and Exacerbate the Development of Experimental Autoimmune Uveitis (EAU) in Mice. 61
31985304 2021
5
Longdan Xiegan Decoction alleviates experimental autoimmune uveitis in rats by inhibiting Notch signaling pathway activation and Th17 cell differentiation. 61
33493870 2021
6
Deviant proteome profile of equine granulocytes associates to latent activation status in organ specific autoimmune disease. 61
32977044 2021
7
Tregs in Autoimmune Uveitis. 61
33523450 2021
8
Analysis of Regulatory B Cells in Experimental Autoimmune Uveitis. 61
33479912 2021
9
Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis. 61
32422390 2021
10
Sirolimus-Loaded Intravitreal Implant for Effective Treatment of Experimental Uveitis. 61
33404988 2021
11
Severity of Experimental Autoimmune Uveitis Is Reduced by Pretreatment with Live Probiotic Escherichia coli Nissle 1917. 61
33375578 2020
12
Functionally distinct IFN-γ+ IL-17A+ Th cells in experimental autoimmune uveitis: T-cell heterogeneity, migration, and steroid response. 61
32652562 2020
13
Identifying Mouse Autoimmune Uveitis from Fundus Photographs Using Deep Learning. 61
33294300 2020
14
Complete blood count parameters and neutrophil-to-lymphocyte ratio values as markers for differentiation between systemic infectious and non-infectious uveitis. 61
32617803 2020
15
Autoimmunity to neuroretina in the concurrent absence of IFN-γ and IL-17A is mediated by a GM-CSF-driven eosinophilic inflammation. 61
32593472 2020
16
A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis. 61
32569628 2020
17
STAT3 deficiency in B cells exacerbates uveitis by promoting expansion of pathogenic lymphocytes and suppressing regulatory B cells (Bregs) and Tregs. 61
33004854 2020
18
IL-10 and IL-17 expression by CD4+ T cells is altered in corticosteroid refractory immune thrombocytopenia (ITP). 61
32574429 2020
19
A cell-permeable peptide inhibitor of p55PIK signaling alleviates ocular inflammation in mouse models of uveitis. 61
32777209 2020
20
Quantitative proteomic analysis of rat retina with experimental autoimmune uveitis based on tandem mass tag (TMT) peptide labeling coupled with LC-MS/MS. 61
32750637 2020
21
Soluble cytokine receptor levels in aqueous humour of patients with specific autoimmune uveitic entities: sCD30 is a biomarker of granulomatous uveitis. 61
31804623 2020
22
The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24. 61
32673565 2020
23
Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation. 61
32829384 2020
24
miR-182-5p inhibits the pathogenic Th17 response in experimental autoimmune uveitis mice via suppressing TAF15. 61
32736708 2020
25
Matairesinol ameliorates experimental autoimmune uveitis by suppression of IRBP-specific Th17 cells. 61
32559555 2020
26
Immunosuppression in the Management of Presumed Non-infective Uveitis; Are We Sure What We are Treating? Notes on the Antimicrobial Properties of the Systemic Immunosuppressants. 61
31418624 2020
27
Analysis of the role of palmitoleic acid in acute anterior uveitis. 61
32422526 2020
28
TIGIT+ A2Ar-Dependent anti-uveitic Treg cells are a novel subset of Tregs associated with resolution of autoimmune uveitis. 61
32201225 2020
29
The Role of Gut Microbiome in Autoimmune Uveitis. 61
32674100 2020
30
Proteomics Profiling of Plasma Exosomes in VKH Patients 61
32682377 2020
31
The relationship between TIGIT+ regulatory T cells and autoimmune disease. 61
32172208 2020
32
An Increase of Oxidized Phospholipids and the Role of Macrophages in Intraocular Inflammation. 61
32526032 2020
33
Altered gut microbiome composition in patients with Vogt-Koyanagi-Harada disease. 61
31928124 2020
34
Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice. 61
32380695 2020
35
Treating Autoimmune Diseases by Targeting IL-23 with Gene-Silencing Pyrrole-Imidazole Polyamide. 61
32169850 2020
36
Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis. 61
32044663 2020
37
Retinal endothelial cell phenotypic modifications during experimental autoimmune uveitis: a transcriptomic approach. 61
32183784 2020
38
Do epigenetic changes caused by commensal microbiota contribute to development of ocular disease? A review of evidence. 61
32169120 2020
39
A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina. 61
32118582 2020
40
DAPT reverses the Th17/Treg imbalance in experimental autoimmune uveitis in vitro via inhibiting Notch signaling pathway. 61
31863921 2020
41
Therapeutic potential of aryl hydrocarbon receptor in autoimmunity. 61
31617124 2020
42
Soluble CD83 Regulates Dendritic Cell-T Cell Immunological Synapse Formation by Disrupting Rab1a-Mediated F-Actin Rearrangement. 61
33585445 2020
43
Dracocephalum heterophyllum (DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4+ T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis. 61
33117376 2020
44
Roles of Exosomes in Ocular Diseases. 61
33402823 2020
45
Aberrant Migratory Behavior of Immune Cells in Recurrent Autoimmune Uveitis in Horses. 61
32211402 2020
46
Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis. 61
32547555 2020
47
Regulated Tristetraprolin Overexpression Dampens the Development and Pathogenesis of Experimental Autoimmune Uveitis. 61
33569048 2020
48
Immunological Insights in Equine Recurrent Uveitis. 61
33488614 2020
49
Association between islet autoantibodies and the prevalence of autoimmune uveitis. 61
33215003 2020
50
Apremilast Regulates the Teff/Treg Balance to Ameliorate Uveitis via PI3K/AKT/FoxO1 Signaling Pathway. 61
33281814 2020

Variations for Autoimmune Uveitis

Expression for Autoimmune Uveitis

Search GEO for disease gene expression data for Autoimmune Uveitis.

Pathways for Autoimmune Uveitis

Pathways related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 TNF IL4 IL22RA1 IL22 IL2 IL1B
2
Show member pathways
13.93 TNF TGFB2 IL4 IL22RA1 IL22 IL2
3
Show member pathways
13.78 TNF TGFB2 IL4 IL22RA1 IL22 IL2
4
Show member pathways
13.61 TNF TGFB2 IL4 IL22RA1 IL22 IL2
5
Show member pathways
13.5 TNF TGFB2 IL4 IL22RA1 IL22 IL2
6
Show member pathways
13.42 TNF IL4 IL22RA1 IL22 IL2 IL1B
7
Show member pathways
13.41 TNF TGFB2 IL4 IL22RA1 IL22 IL2
8
Show member pathways
13.18 TNF TGFB2 IL2 IL1B IL10 IFNG
9
Show member pathways
12.96 TNF IL4 IL22 IL2 IL1B IL17A
10
Show member pathways
12.9 TNF IL2 IL1B IFNG ICAM1 CCL2
11
Show member pathways
12.74 TNF IL4 IL2 IL1B IL17A IL10
12
Show member pathways
12.72 TNF IL2 IL1B IL17A IL10 IFNG
13
Show member pathways
12.69 TNF IL4 IL2 IL10 IFNG
14 12.62 TRIB2 TNF IL4 IL2 IL1B IL17A
15
Show member pathways
12.59 TNF IL4 IL2 IFNG ICAM1
16
Show member pathways
12.56 IL4 IL22RA1 IL22 IL2 IL10 IFNG
17
Show member pathways
12.56 TNF TGFB2 IL4 IL22RA1 IL22 IL2
18
Show member pathways
12.48 TNF IL4 IL1B IL17A IFNG CCL2
19
Show member pathways
12.48 TNF IL4 IL2 IL1B IFNG ICAM1
20
Show member pathways
12.47 TNF IL22RA1 IL2 IL10 CCL3 CCL2
21
Show member pathways
12.41 TNF TGFB2 IL4 IL1B IL10 IFNG
22
Show member pathways
12.4 TNF TGFB2 IL4 IL2 IL1B IL17A
23 12.38 TNF TGFB2 IL2 ICAM1
24
Show member pathways
12.37 SAG RPE65 RLBP1 RBP3
25 12.36 TNF TGFB2 IL1B IL10 IFNG
26
Show member pathways
12.27 TNF IL2 IL1B IL10
27
Show member pathways
12.25 TNF IL4 IL1B IFNG
28 12.24 TNF IL1B IFNG ICAM1 CCL2
29 12.23 TNF IL2 IL1B IL10 CCL2
30 12.15 TNF IL4 IL2 IL1B IFNG ICAM1
31 12.14 TNF IL4 IL2 IL10 IFNG
32 12.13 TNF TGFB2 IL1B IFNG
33
Show member pathways
12.13 IL4 IL2 IL1B IFNG CCL3
34 12.1 TNF IL4 IL1B IL17A IL10 ICAM1
35 12.08 TNF TGFB2 IL1B IL10 IFNG
36 12.07 TNF TGFB2 IL1B ICAM1 CCL2
37 12.06 TNF IL1B ICAM1 CCL2
38
Show member pathways
12.01 TGFB2 IL4 IL22 IL1B IL17A IFNG
39 11.99 SAG RPE65 RLBP1 RBP3
40 11.92 IL4 IL2 IFNG ICAM1
41
Show member pathways
11.91 TNF IL2 IL1B IL17A IL10 IFNG
42 11.9 TNF IL2 IL1B IL10 IFNG
43
Show member pathways
11.89 TNF IL4 IL2 IFNG
44 11.85 TNF TGFB2 IL4 IL10 ICAM1
45
Show member pathways
11.82 TNF IL2 IL1B IFNG ICAM1
46 11.81 TNF IL4 IL1B CCL3 CCL2
47 11.8 TNF IL1B IL10
48
Show member pathways
11.7 TNF IL2 IFNG
49 11.68 TNF IL1B IFNG CCL2
50 11.68 TNF IL2 IL1B IFNG

GO Terms for Autoimmune Uveitis

Cellular components related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNF TGFB2 RBP3 IL4 IL22 IL2
2 extracellular space GO:0005615 9.44 TNF TGFB2 RBP3 IL4 IL22 IL2

Biological processes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.13 TNF IL4 IL1B IFNG CCL3
2 cell-cell signaling GO:0007267 10.02 IL2 IL1B IL17A CCL3
3 inflammatory response GO:0006954 10.02 TNF IL22 IL1B IL17A CCL3 CCL2
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.01 TNF ICAM1 CCL3 CCL2
5 visual perception GO:0007601 10.01 RPE65 RLBP1 RBP3 CRYAA
6 positive regulation of protein phosphorylation GO:0001934 10 TNF IL2 IL1B IFNG
7 MAPK cascade GO:0000165 10 TNF IL2 IL1B CCL3 CCL2
8 neutrophil chemotaxis GO:0030593 9.9 TGFB2 CCL3 CCL2
9 regulation of insulin secretion GO:0050796 9.9 TNF IL1B IFNG
10 response to glucocorticoid GO:0051384 9.89 TNF IL22 IL10
11 positive regulation of interferon-gamma production GO:0032729 9.88 TNF IL2 IL1B
12 positive regulation of T cell proliferation GO:0042102 9.88 IL4 IL2 IL1B
13 cellular response to lipopolysaccharide GO:0071222 9.88 TNF IL1B IL10 ICAM1 CCL2
14 retinoid metabolic process GO:0001523 9.87 RPE65 RLBP1 RBP3
15 positive regulation of interleukin-6 production GO:0032755 9.87 TNF IL1B IL17A IFNG
16 humoral immune response GO:0006959 9.86 TNF IFNG CCL2
17 positive regulation of neuron apoptotic process GO:0043525 9.86 TNF TGFB2 CCL3
18 cellular response to interleukin-1 GO:0071347 9.86 IL17A ICAM1 CCL3 CCL2
19 positive regulation of cytokine production GO:0001819 9.85 TNF IL10 IFNG
20 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 TNF IL4 IL2 IFNG
21 positive regulation of phagocytosis GO:0050766 9.82 TNF IL1B IFNG
22 extrinsic apoptotic signaling pathway GO:0097191 9.82 TNF TGFB2 IFNG
23 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.81 TNF TGFB2 IL10
24 negative regulation of endothelial cell apoptotic process GO:2000352 9.8 IL4 IL10 ICAM1
25 cellular response to organic cyclic compound GO:0071407 9.8 TNF IL1B CCL3 CCL2
26 microglial cell activation GO:0001774 9.77 TNF IL4 IFNG
27 positive regulation of interleukin-1 beta production GO:0032731 9.76 TNF IL17A IFNG CCL3
28 positive regulation of osteoclast differentiation GO:0045672 9.75 TNF IL17A IFNG
29 negative regulation of amyloid-beta clearance GO:1900222 9.73 TNF IFNG
30 regulation of establishment of endothelial barrier GO:1903140 9.72 TNF IL1B
31 negative regulation of T-helper 17 cell differentiation GO:2000320 9.72 IL4 IL2
32 positive regulation of isotype switching to IgG isotypes GO:0048304 9.72 IL4 IL2
33 endothelial cell apoptotic process GO:0072577 9.71 TNF IL10
34 positive regulation of nitric oxide biosynthetic process GO:0045429 9.71 TNF IL1B IFNG ICAM1
35 positive regulation of NMDA glutamate receptor activity GO:1904783 9.7 IFNG CCL2
36 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 TNF IL1B IFNG
37 regulation of complement-dependent cytotoxicity GO:1903659 9.69 TGFB2 IL10
38 vascular endothelial growth factor production GO:0010573 9.69 TNF IL1B
39 vitamin A metabolic process GO:0006776 9.69 RPE65 RLBP1
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 TNF IL1B IL10
41 positive regulation of mononuclear cell migration GO:0071677 9.68 TNF IL4
42 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
43 positive regulation of cellular respiration GO:1901857 9.67 IL4 IFNG
44 neuroinflammatory response GO:0150076 9.67 IL4 IFNG
45 protein kinase B signaling GO:0043491 9.67 TNF IL1B CCL3 CCL2
46 astrocyte cell migration GO:0043615 9.66 CCL3 CCL2
47 type 2 immune response GO:0042092 9.66 IL4 IL10
48 positive regulation of interleukin-23 production GO:0032747 9.65 IL17A IFNG
49 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
50 positive regulation of inflammatory response GO:0050729 9.65 TNF IL2 IL1B IFNG CCL3

Molecular functions related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TNF TGFB2 IL4 IL22 IL2 IL1B
2 growth factor activity GO:0008083 9.26 TGFB2 IL4 IL2 IL10
3 retinal binding GO:0016918 9.16 RLBP1 RBP3

Sources for Autoimmune Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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