MCID: ATM099
MIFTS: 50

Autoimmune Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autoimmune Uveitis

MalaCards integrated aliases for Autoimmune Uveitis:

Name: Autoimmune Uveitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040088

Summaries for Autoimmune Uveitis

Disease Ontology : 12 An autoimmune disease of eyes, ear, nose and throat that is located in the uvea.

MalaCards based summary : Autoimmune Uveitis is related to choroiditis and uveitis. An important gene associated with Autoimmune Uveitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Mycophenolic acid and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include t cells, eye and retina, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Autoimmune Uveitis

Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Autoimmune Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 choroiditis 29.9 IL10 TNF
2 uveitis 29.8 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
3 posterior uveitis 29.5 CAPN5 IFNG IL2 RBP3 SAG TNF
4 autoimmune disease 28.0 CCL2 IFNG IL10 IL17A IL1B IL2
5 variola major 10.3 IFNG IL2
6 berylliosis 10.3 IFNG IL2
7 fixed drug eruption 10.3 IFNG IL2
8 toxicodendron dermatitis 10.3 ICAM1 IL2
9 autoimmune enteropathy 10.3 ICAM1 IL17A
10 cephalosporin allergy 10.3 IFNG IL10
11 sporotrichosis 10.3 IFNG IL10
12 acute zonal occult outer retinopathy 10.2 RLBP1 SAG
13 neurosyphilis 10.2 IL10 IL17A
14 cardiac sarcoidosis 10.2 IFNG TNF
15 campylobacteriosis 10.2 IFNG IL1B
16 miliary tuberculosis 10.2 IFNG TNF
17 farmer's lung 10.2 IL2 TNF
18 chronic beryllium disease 10.2 IFNG TNF
19 oral tuberculosis 10.2 IL2 TNF
20 focal segmental glomerulosclerosis 1 10.2 ICAM1 IL1B
21 streptococcal toxic-shock syndrome 10.2 IL2 TNF
22 uremic pruritus 10.2 IL1B IL2
23 shwartzman phenomenon 10.2 ICAM1 TNF
24 b-cell growth factor 10.2 IFNG IL4
25 autoimmune disease of endocrine system 10.2 ICAM1 IFNG IL2
26 crustacean allergy 10.2 IFNG IL4
27 angiostrongyliasis 10.2 IL2 IL4
28 funisitis 10.2 IL10 IL1B
29 cow milk allergy 10.2 IL10 TNF
30 trichuriasis 10.2 IL10 TNF
31 transient hypogammaglobulinemia 10.2 IL10 TNF
32 virus associated hemophagocytic syndrome 10.2 IL2 IL4
33 jak3-deficient severe combined immunodeficiency 10.2 IL2 IL4
34 mucocutaneous leishmaniasis 10.2 IL10 TNF
35 idiopathic achalasia 10.2 IL10 TNF
36 microscopic polyangiitis 10.2 IL10 TNF
37 multifocal choroiditis 10.2 IL10 TNF
38 punctate inner choroidopathy 10.2 IL10 TNF
39 fundus albipunctatus 10.2 RBP3 RLBP1 SAG
40 herpes zoster 10.1 IFNG IL10 IL2
41 retinitis pigmentosa 22 10.1 IL10 IL4
42 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 IFNG IL10 IL17A
43 apple allergy 10.1 IL10 IL4
44 beta-lactam allergy 10.1 IL10 IL4
45 kashin-beck disease 10.1 IL1B TNF
46 burns 10.1 IL1B TNF
47 glossitis 10.1 IL1B TNF
48 laryngitis 10.1 IL1B TNF
49 exudative glomerulonephritis 10.1 IL1B TNF
50 haemophilus influenzae 10.1 IL1B TNF

Graphical network of the top 20 diseases related to Autoimmune Uveitis:



Diseases related to Autoimmune Uveitis

Symptoms & Phenotypes for Autoimmune Uveitis

GenomeRNAi Phenotypes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ICAM1 IL10 IL17A IL1B IL2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ICAM1 IL10 IL17A IL1B IL2 TNF

MGI Mouse Phenotypes related to Autoimmune Uveitis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.19 CAPN5 ICAM1 IFNG IL10 IL17A IL1B
2 immune system MP:0005387 10.17 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
3 homeostasis/metabolism MP:0005376 10.16 ICAM1 IFNG IL10 IL17A IL1B IL2
4 hematopoietic system MP:0005397 10.13 ICAM1 IFNG IL10 IL17A IL1B IL2
5 mortality/aging MP:0010768 10.07 CAPN5 ICAM1 IFNG IL10 IL17A IL1B
6 digestive/alimentary MP:0005381 10.05 ICAM1 IFNG IL10 IL17A IL2 IL4
7 craniofacial MP:0005382 10 IFNG IL10 IL17A IL1B IL4 TNF
8 nervous system MP:0003631 9.96 ICAM1 IFNG IL10 IL1B IL4 RBP3
9 integument MP:0010771 9.95 ICAM1 IFNG IL10 IL1B IL4 RLBP1
10 neoplasm MP:0002006 9.8 ICAM1 IFNG IL10 IL1B IL2 TNF
11 no phenotypic analysis MP:0003012 9.7 IFNG IL10 IL17A IL2 IL4 TNF
12 respiratory system MP:0005388 9.43 IFNG IL10 IL17A IL2 IL4 TNF
13 vision/eye MP:0005391 9.28 ICAM1 IFNG IL10 IL2 IL4 RBP3

Drugs & Therapeutics for Autoimmune Uveitis

Drugs for Autoimmune Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved 24280-93-1 446541
2
Curcumin Approved, Experimental, Investigational Early Phase 1 458-37-7 969516
3
Metformin Approved Not Applicable 657-24-9 14219 4091
4 Antitubercular Agents
5 Anti-Bacterial Agents
6 Antibiotics, Antitubercular
7 Anti-Infective Agents
8 Anti-Inflammatory Agents Early Phase 1,Not Applicable
9 glucocorticoids Not Applicable
10 Hypoglycemic Agents Not Applicable
11 Hormones Not Applicable
12 Hormone Antagonists Not Applicable
13 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mycophenolate Sodium (Myfortic®) in the Treatment of Corticosteroid-refractory Autoimmune Uveitis:Pilot Study Unknown status NCT01261169 Myfortic
2 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
3 Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis Recruiting NCT03584724 Early Phase 1 Norflo Oro;Placebo for Norflo Oro
4 A Clinical Trial of Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis Not yet recruiting NCT03525028 Not Applicable Metformin;Placebo

Search NIH Clinical Center for Autoimmune Uveitis

Genetic Tests for Autoimmune Uveitis

Anatomical Context for Autoimmune Uveitis

MalaCards organs/tissues related to Autoimmune Uveitis:

41
T Cells, Eye, Retina, Monocytes, B Cells, Lung, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Uveitis:

19
The Uvea

Publications for Autoimmune Uveitis

Articles related to Autoimmune Uveitis:

(show top 50) (show all 363)
# Title Authors Year
1
Mesenchymal stem cells inhibited dendritic cells via the regulation of STAT1 and STAT6 phosphorylation in experimental autoimmune uveitis. ( 29424313 )
2018
2
Author Correction: Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. ( 29941876 )
2018
3
Total glucosides of paeony suppresses experimental autoimmune uveitis in association with inhibition of Th1 and Th2 cell function in mice. ( 29363368 )
2018
4
Targeting CD6 for the treatment of experimental autoimmune uveitis. ( 29472120 )
2018
5
The immunopathogenesis of chronic and relapsing autoimmune uveitis - Lessons from experimental rat models. ( 29496590 )
2018
6
Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis. ( 29572578 )
2018
7
Local S100A8 Levels Correlate With Recurrence of Experimental Autoimmune Uveitis and Promote Pathogenic T Cell Activity. ( 29625456 )
2018
8
Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis. ( 29752572 )
2018
9
Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis. ( 30004859 )
2018
10
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis. ( 30048621 )
2018
11
Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells. ( 30050530 )
2018
12
Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis. ( 30090104 )
2018
13
Subretinal Transplantation of Human Amniotic Epithelial Cells in the Treatment of Autoimmune Uveitis in Rats. ( 30168350 )
2018
14
TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations. ( 30218573 )
2018
15
Adenosine receptor activation in the Th17 autoimmune responses of experimental autoimmune uveitis. ( 30249343 )
2018
16
Dynamic DNA Methylation Changes of Tbx21 and Rorc during Experimental Autoimmune Uveitis in Mice. ( 30254507 )
2018
17
Commentary: Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells. ( 30498498 )
2018
18
Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro. ( 30510488 )
2018
19
CD83+ CCR7+ NK cells induced by interleukin 18 by dendritic cells promote experimental autoimmune uveitis. ( 30548211 )
2018
20
Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Decrease the Development of Severe Experimental Autoimmune Uveitis in B10.RIII Mice. ( 28914568 )
2017
21
Correction: Regulation of Adenosine Deaminase on Induced Mouse Experimental Autoimmune Uveitis. ( 28069759 )
2017
22
Functional Conversion and Dominance of I^I' T Subset in Mouse Experimental Autoimmune Uveitis. ( 28069804 )
2017
23
Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice. ( 26996065 )
2017
24
Formin like 1 expression is increased on CD4+ T lymphocytes in spontaneous autoimmune uveitis. ( 28057602 )
2017
25
Commensal microbiota as a potential trigger of autoimmune uveitis. ( 28145784 )
2017
26
Proteomic Profiling Analysis Reveals a Link between Experimental Autoimmune Uveitis and Complement Activation in Rats. ( 28199731 )
2017
27
Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production. ( 28248972 )
2017
28
The HMGB1-CXCL12 Complex Promotes Inflammatory Cell Infiltration in Uveitogenic T Cell-Induced Chronic Experimental Autoimmune Uveitis. ( 28261206 )
2017
29
Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice. ( 28267649 )
2017
30
Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. ( 28659587 )
2017
31
MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis. ( 28720143 )
2017
32
Targeting interleukin-6 in autoimmune uveitis. ( 28778705 )
2017
33
Proteome Dynamics in Biobanked Horse Peripheral Blood Derived Lymphocytes (PBL) with Induced Autoimmune Uveitis. ( 28846213 )
2017
34
Behavioral Conditioning of Immune Responses with Cyclosporine A in a Murine Model of Experimental Autoimmune Uveitis. ( 28848192 )
2017
35
Complement Component C4 Regulates the Development of Experimental Autoimmune Uveitis through a T Cell-Intrinsic Mechanism. ( 28955337 )
2017
36
NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis. ( 29038541 )
2017
37
Ly6Chi monocytes are required for mesenchymal stem/stromal cell-induced immune tolerance in mice with experimental autoimmune uveitis. ( 29056505 )
2017
38
Gut microbiota linked to autoimmune uveitis. ( 30310875 )
2017
39
Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). ( 27196432 )
2016
40
The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis. ( 27166675 )
2016
41
Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis. ( 27564686 )
2016
42
Digoxin Inhibits Induction of Experimental Autoimmune Uveitis in Mice, but Causes Severe Retinal Degeneration. ( 27028065 )
2016
43
Autoimmune uveitis: clinical, pathogenetic, and therapeutic features. ( 25820692 )
2016
44
Influence of Yanyankang Powder on Th1/Th2 in rats with experimental autoimmune uveitis. ( 26129902 )
2016
45
Imbalance Between Th17 Cells and Regulatory T Cells During Monophasic Experimental Autoimmune Uveitis. ( 26296290 )
2016
46
Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis. ( 26394814 )
2016
47
Modulating of ocular inflammation with macrophage migration inhibitory factor is associated with notch signalling in experimental autoimmune uveitis. ( 26400205 )
2016
48
Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis. ( 26643477 )
2016
49
Tertiary Lymphoid Tissue Forms in Retinas of Mice with Spontaneous Autoimmune Uveitis and Has Consequences on Visual Function. ( 26712943 )
2016
50
Multiple etiologies of equine recurrent uveitis--A natural model for human autoimmune uveitis: A brief review. ( 26851589 )
2016

Variations for Autoimmune Uveitis

Expression for Autoimmune Uveitis

Search GEO for disease gene expression data for Autoimmune Uveitis.

Pathways for Autoimmune Uveitis

Pathways related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.99 CCL2 ICAM1 IFNG IL10 IL17A IL1B
2
Show member pathways
13.81 CAPN5 CCL2 IL10 IL17A IL1B IL2
3
Show member pathways
13.67 CCL2 IFNG IL10 IL17A IL1B IL2
4
Show member pathways
13.56 CCL2 ICAM1 IFNG IL10 IL17A IL1B
5
Show member pathways
13.41 CCL2 IL10 IL17A IL1B IL2 IL4
6
Show member pathways
13.4 CCL2 ICAM1 IFNG IL10 IL17A IL1B
7
Show member pathways
13.31 CCL2 IL10 IL17A IL1B IL2 IL4
8
Show member pathways
13.04 CCL2 IFNG IL10 IL1B IL2 TNF
9
Show member pathways
12.95 ICAM1 IFNG IL10 IL17A IL1B IL2
10
Show member pathways
12.87 CCL2 ICAM1 IFNG IL1B IL2 IL4
11
Show member pathways
12.68 IFNG IL10 IL17A IL1B IL2 IL4
12
Show member pathways
12.66 IFNG IL10 IL2 IL4 TNF
13
Show member pathways
12.66 CCL2 IFNG IL10 IL17A IL1B IL2
14
Show member pathways
12.57 ICAM1 IFNG IL2 IL4 TNF
15
Show member pathways
12.5 IFNG IL10 IL17A IL1B IL2 IL4
16
Show member pathways
12.43 CCL2 IFNG IL17A IL1B IL4 TNF
17 12.42 CCL2 IFNG IL10 IL17A IL1B IL2
18
Show member pathways
12.41 CCL2 ICAM1 IFNG IL1B IL2 IL4
19
Show member pathways
12.4 IFNG IL10 IL2 IL4
20
Show member pathways
12.34 IFNG IL10 IL1B IL4 TNF
21
Show member pathways
12.34 IFNG IL10 IL17A IL1B IL2 IL4
22 12.27 IFNG IL10 IL1B TNF
23
Show member pathways
12.25 IL10 IL1B IL2 TNF
24
Show member pathways
12.23 IFNG IL1B IL4 TNF
25 12.19 CCL2 ICAM1 IFNG IL1B TNF
26
Show member pathways
12.15 IFNG IL10 IL17A IL1B IL2 TNF
27
Show member pathways
12.1 IFNG IL1B IL4 TNF
28 12.1 IFNG IL10 IL2 IL4 TNF
29
Show member pathways
12.09 CCL2 ICAM1 IFNG IL10 IL17A IL1B
30 12.06 CCL2 ICAM1 IFNG IL1B IL2 IL4
31
Show member pathways
12.04 IFNG IL1B IL2 IL4
32 12.03 CCL2 ICAM1 IL1B TNF
33 12.02 IFNG IL1B TNF
34 11.98 CCL2 ICAM1 IL1B TNF
35 11.97 IFNG IL10 IL1B TNF
36 11.93 CCL2 ICAM1 IFNG IL17A IL1B TNF
37 11.92 CCL2 ICAM1 IL10 IL17A IL1B IL4
38 11.9 IL1B IL4 TNF
39 11.89 ICAM1 IFNG IL2 IL4
40 11.88 RBP3 RLBP1 SAG
41 11.88 ICAM1 IL1B TNF
42 11.88 IFNG IL10 IL1B IL2 TNF
43 11.86 IFNG IL10 IL2
44
Show member pathways
11.86 IFNG IL2 IL4 TNF
45 11.78 IL10 IL1B TNF
46 11.77 CCL2 IL1B IL4 TNF
47
Show member pathways
11.77 ICAM1 IFNG IL1B IL2 TNF
48
Show member pathways
11.68 IFNG IL2 TNF
49 11.64 IFNG IL1B IL2 TNF
50 11.64 CCL2 IFNG IL1B TNF

GO Terms for Autoimmune Uveitis

Cellular components related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL2 IFNG IL10 IL17A IL1B IL2
2 extracellular space GO:0005615 9.32 CCL2 ICAM1 IFNG IL10 IL17A IL1B

Biological processes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.97 CCL2 ICAM1 IL1B TNF
2 inflammatory response GO:0006954 9.95 CCL2 IL10 IL17A IL1B TNF
3 MAPK cascade GO:0000165 9.94 CCL2 IL1B IL2 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.9 IFNG IL1B IL2 TNF
5 response to ethanol GO:0045471 9.87 ICAM1 IL1B IL2
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.86 IL10 IL1B TNF
7 cellular response to interleukin-1 GO:0071347 9.85 CCL2 ICAM1 IL17A
8 cellular response to organic cyclic compound GO:0071407 9.84 CCL2 IL1B TNF
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 IFNG IL2 IL4
10 regulation of insulin secretion GO:0050796 9.83 IFNG IL1B TNF
11 response to glucocorticoid GO:0051384 9.82 IL10 IL1B TNF
12 positive regulation of T cell proliferation GO:0042102 9.81 IL1B IL2 IL4
13 humoral immune response GO:0006959 9.79 CCL2 IFNG TNF
14 cellular response to lipopolysaccharide GO:0071222 9.77 CCL2 ICAM1 IL10 IL1B TNF
15 immune response GO:0006955 9.76 CCL2 IFNG IL10 IL17A IL1B IL2
16 positive regulation of interferon-gamma production GO:0032729 9.73 IL1B IL2 TNF
17 positive regulation of T cell differentiation GO:0045582 9.71 IL2 IL4
18 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
19 positive regulation of glial cell proliferation GO:0060252 9.7 IL1B TNF
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.7 IL1B TNF
21 regulation of regulatory T cell differentiation GO:0045589 9.7 IFNG IL2
22 protein kinase B signaling GO:0043491 9.7 CCL2 IL1B TNF
23 negative regulation of growth of symbiont in host GO:0044130 9.69 IL10 TNF
24 negative regulation of endothelial cell apoptotic process GO:2000352 9.69 ICAM1 IL10 IL4
25 positive regulation of isotype switching to IgG isotypes GO:0048304 9.68 IL2 IL4
26 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TNF
29 positive regulation of MHC class II biosynthetic process GO:0045348 9.66 IL10 IL4
30 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
31 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.63 ICAM1 TNF
33 positive regulation of osteoclast differentiation GO:0045672 9.63 IFNG IL17A TNF
34 positive regulation of neuroinflammatory response GO:0150078 9.62 IL1B TNF
35 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 ICAM1 IFNG IL1B TNF
36 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
37 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
38 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG IL1B TNF
39 chronic inflammatory response to antigenic stimulus GO:0002439 9.59 IL1B TNF
40 regulation of isotype switching GO:0045191 9.58 IL10 IL4
41 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
42 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
43 type 2 immune response GO:0042092 9.57 IL10 IL4
44 regulation of signaling receptor activity GO:0010469 9.56 CCL2 IFNG IL10 IL17A IL1B IL2
45 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
46 positive regulation of vitamin D biosynthetic process GO:0060557 9.48 IFNG TNF
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IFNG IL1B TNF
48 cytokine-mediated signaling pathway GO:0019221 9.23 CCL2 ICAM1 IL10 IL17A IL1B IL2
49 positive regulation of transcription by RNA polymerase II GO:0045944 10.16 IL10 IL17A IL1B IL2 IL4 TNF

Molecular functions related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.23 CCL2 IFNG IL10 IL17A IL1B IL2
2 retinol binding GO:0019841 9.16 RBP3 RLBP1
3 retinal binding GO:0016918 8.96 RBP3 RLBP1

Sources for Autoimmune Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....