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MCID: ATM099
MIFTS: 51

Autoimmune Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Autoimmune Uveitis

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MalaCards integrated aliases for Autoimmune Uveitis:

Name: Autoimmune Uveitis 12 15

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Immune diseases Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040088
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Summaries for Autoimmune Uveitis

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Disease Ontology : 12 An autoimmune disease of eyes, ear, nose and throat that is located in the uvea.

MalaCards based summary : Autoimmune Uveitis is related to choroiditis and posterior uveitis. An important gene associated with Autoimmune Uveitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Mycophenolic acid and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include t cells, eye and lung, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Autoimmune Uveitis

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Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Autoimmune Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 301)
# Related Disease Score Top Affiliating Genes
1 choroiditis 30.2 IL10 TNF
2 posterior uveitis 29.4 CAPN5 IFNG IL2 RBP3 SAG TNF
3 vitreoretinopathy, neovascular inflammatory 29.4 CAPN5 CCL2 TGFB2
4 uveitis 28.9 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
5 autoimmune disease 28.2 IFNG IL10 IL17A IL1B IL2 IL4
6 variola major 10.5 IFNG IL2
7 berylliosis 10.5 IFNG IL2
8 fixed drug eruption 10.5 IFNG IL2
9 toxicodendron dermatitis 10.5 ICAM1 IL2
10 cephalosporin allergy 10.4 IFNG IL10
11 sporotrichosis 10.4 IFNG IL10
12 autoimmune enteropathy 10.4 ICAM1 IL17A
13 acute zonal occult outer retinopathy 10.4 RLBP1 SAG
14 neurosyphilis 10.4 IL10 IL17A
15 autoimmune myocarditis 10.4 IFNG TNF
16 miliary tuberculosis 10.4 IFNG TNF
17 farmer's lung 10.4 IL2 TNF
18 chronic beryllium disease 10.4 IFNG TNF
19 oral tuberculosis 10.4 IL2 TNF
20 streptococcal toxic-shock syndrome 10.4 IL2 TNF
21 shwartzman phenomenon 10.4 ICAM1 TNF
22 b-cell growth factor 10.4 IFNG IL4
23 penicillin allergy 10.3 IFNG IL4
24 crustacean allergy 10.3 IFNG IL4
25 angiostrongyliasis 10.3 IL2 IL4
26 cow milk allergy 10.3 IL10 TNF
27 trichuriasis 10.3 IL10 TNF
28 transient hypogammaglobulinemia 10.3 IL10 TNF
29 mucocutaneous leishmaniasis 10.3 IL10 TNF
30 idiopathic achalasia 10.3 IL10 TNF
31 multifocal choroiditis 10.3 IL10 TNF
32 punctate inner choroidopathy 10.3 IL10 TNF
33 virus associated hemophagocytic syndrome 10.3 IL2 IL4
34 jak3-deficient severe combined immunodeficiency 10.3 IL2 IL4
35 autoimmune disease of endocrine system 10.3 ICAM1 IFNG IL2
36 retinitis pigmentosa 22 10.3 IL10 IL4
37 fundus albipunctatus 10.3 RBP3 RLBP1 SAG
38 apple allergy 10.3 IL10 IL4
39 beta-lactam allergy 10.3 IL10 IL4
40 campylobacteriosis 10.3 IFNG IL1B
41 preretinal fibrosis 10.3 RLBP1 TGFB2
42 herpes zoster 10.3 IFNG IL10 IL2
43 focal segmental glomerulosclerosis 1 10.3 ICAM1 IL1B
44 uremic pruritus 10.3 IL1B IL2
45 funisitis 10.2 IL10 IL1B
46 candidiasis 10.2 IFNG IL10 IL17A
47 mumps 10.2 IFNG IL2 TNF
48 hypersensitivity reaction type iv disease 10.2 IFNG IL2 TNF
49 smallpox 10.2 IFNG IL2 TNF
50 onchocerciasis 10.2 IL2 IL4 RBP3

Graphical network of the top 20 diseases related to Autoimmune Uveitis:



Diseases related to Autoimmune Uveitis
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Symptoms & Phenotypes for Autoimmune Uveitis

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GenomeRNAi Phenotypes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ICAM1 IL10 IL17A IL1B IL2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ICAM1 IL10 IL17A IL1B IL2 TNF

MGI Mouse Phenotypes related to Autoimmune Uveitis:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.21 CAPN5 ICAM1 IFNG IL10 IL17A IL1B
2 immune system MP:0005387 10.2 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
3 homeostasis/metabolism MP:0005376 10.18 ICAM1 IFNG IL10 IL17A IL1B IL2
4 cardiovascular system MP:0005385 10.16 ICAM1 IFNG IL10 IL1B IL2 RLBP1
5 hematopoietic system MP:0005397 10.15 ICAM1 IFNG IL10 IL17A IL1B IL2
6 digestive/alimentary MP:0005381 10.14 ICAM1 IFNG IL10 IL17A IL2 IL4
7 endocrine/exocrine gland MP:0005379 10.13 ICAM1 IFNG IL10 IL17A IL2 IL4
8 mortality/aging MP:0010768 10.1 CAPN5 ICAM1 IFNG IL10 IL17A IL1B
9 craniofacial MP:0005382 10.09 IFNG IL10 IL17A IL1B IL4 TGFB2
10 nervous system MP:0003631 10.02 ICAM1 IFNG IL10 IL1B IL4 RBP3
11 integument MP:0010771 9.98 ICAM1 IFNG IL10 IL1B IL4 RLBP1
12 neoplasm MP:0002006 9.85 ICAM1 IFNG IL10 IL1B IL2 TNF
13 no phenotypic analysis MP:0003012 9.73 IFNG IL10 IL17A IL2 IL4 TNF
14 respiratory system MP:0005388 9.7 IFNG IL10 IL17A IL2 IL4 TGFB2
15 skeleton MP:0005390 9.56 IFNG IL10 IL17A IL1B IL4 RLBP1
16 vision/eye MP:0005391 9.32 ICAM1 IFNG IL10 IL2 IL4 RBP3
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Drugs & Therapeutics for Autoimmune Uveitis

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Drugs for Autoimmune Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved 24280-93-1 446541
2
Curcumin Approved, Experimental, Investigational Early Phase 1 458-37-7 969516
3
Azathioprine Approved 446-86-6 2265
4
Methotrexate Approved 1959-05-2, 59-05-2 126941
5
Sirolimus Approved, Investigational 53123-88-9 46835353 5284616 6436030
6
Tacrolimus Approved, Investigational 104987-11-3 6473866 445643 439492
7
Adalimumab Approved 331731-18-1 16219006
8
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
9
Infliximab Approved 170277-31-3
10
Chlorambucil Approved 305-03-3 2708
11
Metformin Approved Not Applicable 657-24-9 14219 4091
12 Anti-Infective Agents
13 Antibiotics, Antitubercular
14 Antitubercular Agents
15 Anti-Bacterial Agents
16 Anti-Inflammatory Agents Early Phase 1,Not Applicable
17 Cyclosporins
18 Calcineurin Inhibitors
19 Immunosuppressive Agents
20 Alkylating Agents
21 Immunologic Factors
22 Antimetabolites
23 glucocorticoids Not Applicable
24 Hypoglycemic Agents Not Applicable
25 Hormone Antagonists Not Applicable
26 Hormones Not Applicable
27 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mycophenolate Sodium (Myfortic®) in the Treatment of Corticosteroid-refractory Autoimmune Uveitis:Pilot Study Unknown status NCT01261169 Myfortic
2 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
3 Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis Recruiting NCT03584724 Early Phase 1 Norflo Oro;Placebo for Norflo Oro
4 Treatment Outcome of Uveitis in Autoimmune Diseases Not yet recruiting NCT03886233 Corticosteroid Series
5 A Clinical Trial of Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis Not yet recruiting NCT03525028 Not Applicable Metformin;Placebo

Search NIH Clinical Center for Autoimmune Uveitis

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Genetic Tests for Autoimmune Uveitis

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Anatomical Context for Autoimmune Uveitis

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MalaCards organs/tissues related to Autoimmune Uveitis:

42
T Cells, Eye, Lung, Monocytes, Retina, Pineal, Spleen

The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Uveitis:

20
The Uvea
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Publications for Autoimmune Uveitis

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Articles related to Autoimmune Uveitis:

(show top 50) (show all 372)
# Title Authors Year
1
Evaluation of controlled-release triamcinolone acetonide-loaded mPEG-PLGA nanoparticles in treating experimental autoimmune uveitis. ( 30641491 )
2019
2
Clinical and Functional Evaluation of Ocular Inflammatory Disease Using the Model of Experimental Autoimmune Uveitis. ( 30649775 )
2019
3
Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis. ( 30660629 )
2019
4
Disruption of Intestinal Homeostasis and Intestinal Microbiota During Experimental Autoimmune Uveitis. ( 30695094 )
2019
5
Microbiome and Autoimmune Uveitis. ( 30837991 )
2019
6
AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells. ( 30853312 )
2019
7
The role of interleukins and their inhibitors in the development of autoimmune uveitis. ( 31055563 )
2019
8
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis. ( 30048621 )
2018
9
Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells. ( 30050530 )
2018
10
Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis. ( 30090104 )
2018
11
Subretinal Transplantation of Human Amniotic Epithelial Cells in the Treatment of Autoimmune Uveitis in Rats. ( 30168350 )
2018
12
TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations. ( 30218573 )
2018
13
Adenosine receptor activation in the Th17 autoimmune responses of experimental autoimmune uveitis. ( 30249343 )
2018
14
Dynamic DNA Methylation Changes of Tbx21 and Rorc during Experimental Autoimmune Uveitis in Mice. ( 30254507 )
2018
15
Commentary: Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells. ( 30498498 )
2018
16
Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro. ( 30510488 )
2018
17
CD83+ CCR7+ NK cells induced by interleukin 18 by dendritic cells promote experimental autoimmune uveitis. ( 30548211 )
2018
18
Comparative Analysis of the Interphotoreceptor Retinoid Binding ProteinInduced Models of Experimental Autoimmune Uveitis in B10.RIII versus C57BL/6 Mice. ( 30636608 )
2018
19
Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Decrease the Development of Severe Experimental Autoimmune Uveitis in B10.RIII Mice. ( 28914568 )
2018
20
Total glucosides of paeony suppresses experimental autoimmune uveitis in association with inhibition of Th1 and Th2 cell function in mice. ( 29363368 )
2018
21
Mesenchymal Stem Cells Inhibited Dendritic Cells Via the Regulation of STAT1 and STAT6 Phosphorylation in Experimental Autoimmune Uveitis. ( 29424313 )
2018
22
Targeting CD6 for the treatment of experimental autoimmune uveitis. ( 29472120 )
2018
23
The immunopathogenesis of chronic and relapsing autoimmune uveitis - Lessons from experimental rat models. ( 29496590 )
2018
24
Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis. ( 29572578 )
2018
25
Local S100A8 Levels Correlate With Recurrence of Experimental Autoimmune Uveitis and Promote Pathogenic T Cell Activity. ( 29625456 )
2018
26
Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis. ( 29752572 )
2018
27
Author Correction: Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. ( 29941876 )
2018
28
Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis. ( 30004859 )
2018
29
Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice. ( 26996065 )
2017
30
Formin like 1 expression is increased on CD4+ T lymphocytes in spontaneous autoimmune uveitis. ( 28057602 )
2017
31
Correction: Regulation of Adenosine Deaminase on Induced Mouse Experimental Autoimmune Uveitis. ( 28069759 )
2017
32
Functional Conversion and Dominance of γδ T Subset in Mouse Experimental Autoimmune Uveitis. ( 28069804 )
2017
33
Commensal microbiota as a potential trigger of autoimmune uveitis. ( 28145784 )
2017
34
Proteomic Profiling Analysis Reveals a Link between Experimental Autoimmune Uveitis and Complement Activation in Rats. ( 28199731 )
2017
35
Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production. ( 28248972 )
2017
36
The HMGB1-CXCL12 Complex Promotes Inflammatory Cell Infiltration in Uveitogenic T Cell-Induced Chronic Experimental Autoimmune Uveitis. ( 28261206 )
2017
37
Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice. ( 28267649 )
2017
38
Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. ( 28659587 )
2017
39
MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis. ( 28720143 )
2017
40
Targeting interleukin-6 in autoimmune uveitis. ( 28778705 )
2017
41
Proteome Dynamics in Biobanked Horse Peripheral Blood Derived Lymphocytes (PBL) with Induced Autoimmune Uveitis. ( 28846213 )
2017
42
Behavioral Conditioning of Immune Responses with Cyclosporine A in a Murine Model of Experimental Autoimmune Uveitis. ( 28848192 )
2017
43
Complement Component C4 Regulates the Development of Experimental Autoimmune Uveitis through a T Cell-Intrinsic Mechanism. ( 28955337 )
2017
44
NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis. ( 29038541 )
2017
45
Ly6Chi monocytes are required for mesenchymal stem/stromal cell-induced immune tolerance in mice with experimental autoimmune uveitis. ( 29056505 )
2017
46
Gut microbiota linked to autoimmune uveitis. ( 30310875 )
2017
47
Autoimmune uveitis: clinical, pathogenetic, and therapeutic features. ( 25820692 )
2016
48
Influence of Yanyankang Powder on Th1/Th2 in rats with experimental autoimmune uveitis. ( 26129902 )
2016
49
Imbalance Between Th17 Cells and Regulatory T Cells During Monophasic Experimental Autoimmune Uveitis. ( 26296290 )
2016
50
Complement anaphylatoxin receptors C3aR and C5aR are required in the pathogenesis of experimental autoimmune uveitis. ( 26394814 )
2016
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Variations for Autoimmune Uveitis

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Expression for Autoimmune Uveitis

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Search GEO for disease gene expression data for Autoimmune Uveitis.
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Pathways for Autoimmune Uveitis

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Pathways related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.99 CCL2 ICAM1 IFNG IL10 IL17A IL1B
2
ERK Signaling 65
Show member pathways
 13.85 CAPN5 CCL2 IL10 IL17A IL1B IL2
3
PEDF Induced Signaling 65
Show member pathways
 13.69 CCL2 IFNG IL10 IL17A IL1B IL2
4
TGF-Beta Pathway 65
Show member pathways
 13.59 CCL2 ICAM1 IFNG IL10 IL17A IL1B
5
Akt Signaling 65
Show member pathways
 13.44 CCL2 IL10 IL17A IL1B IL2 IL4
6
Cytokine Signaling in Immune system 67
Show member pathways
 13.42 CCL2 ICAM1 IFNG IL10 IL17A IL1B
7
PAK Pathway 65
Show member pathways
 13.35 CCL2 IL10 IL17A IL1B IL2 IL4
8
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 13.16 CCL2 IFNG IL10 IL1B IL2 TGFB2
9
Allograft rejection 38 1
Show member pathways
 12.95 ICAM1 IFNG IL10 IL17A IL1B IL2
10
Human cytomegalovirus infection 38
Show member pathways
 12.93 CCL2 ICAM1 IL1B TGFB2 TNF
11
Immune response IL-23 signaling pathway 23
Show member pathways
 12.68 CCL2 IFNG IL10 IL17A IL1B IL2
12
NF-KappaB Family Pathway 65
Show member pathways
 12.67 IL1B IL2 TGFB2 TNF
13
Immune response NFAT in immune response 23
Show member pathways
 12.67 IFNG IL10 IL2 IL4 TNF
14
T cell receptor signaling pathway 38
Show member pathways
 12.66 IFNG IL10 IL17A IL1B IL2 IL4
15
Th17 cell differentiation 38
Show member pathways
 12.66 IFNG IL10 IL17A IL1B IL2 IL4
16
NF-kappaB Signaling 4
12.61 CCL2 IFNG IL10 IL17A IL1B IL2
17
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.58 ICAM1 IFNG IL2 IL4 TNF
18
Selenium Micronutrient Network 1
Show member pathways
 12.45 CCL2 ICAM1 IFNG IL1B IL2 IL4
19
IL-17 Family Signaling Pathways 66
Show member pathways
 12.44 CCL2 IFNG IL17A IL1B IL4 TNF
20
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.4 IFNG IL10 IL2 IL4
21
Human T-cell leukemia virus 1 infection 38
12.37 ICAM1 IL2 TGFB2 TNF
22
Toxoplasmosis 38
Show member pathways
 12.37 IFNG IL10 IL1B IL4 TGFB2 TNF
23
Tuberculosis 38
12.33 IFNG IL10 IL1B TGFB2 TNF
24
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.32 IFNG IL10 IL17A IL1B IL2 IL4
25
C-type lectin receptor signaling pathway 38
Show member pathways
 12.26 IL10 IL1B IL2 TNF
26
Bacterial infections in CF airways 23
Show member pathways
 12.24 IFNG IL1B IL4 TNF
27
Fluid shear stress and atherosclerosis 38
12.2 CCL2 ICAM1 IFNG IL1B TNF
28
Th1 Differentiation Pathway 66
Show member pathways
 12.14 IFNG IL10 IL17A IL1B IL2 TGFB2
29
Osteoclast differentiation 38
12.12 IFNG IL1B TGFB2 TNF
30
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.12 IFNG IL10 IL2 IL4 TNF
31
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.11 IFNG IL1B IL4 TNF
32
Spinal Cord Injury 1
12.08 CCL2 ICAM1 IFNG IL1B IL2 IL4
33
IL12-mediated signaling events 1
Show member pathways
 12.05 IFNG IL1B IL2 IL4
34
TNF signaling pathway 38
12.04 CCL2 ICAM1 IL1B TNF
35
AGE-RAGE signaling pathway in diabetic complications 38
12.04 CCL2 ICAM1 IL1B TGFB2 TNF
36
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.03 CCL2 ICAM1 IFNG IL10 IL17A IL1B
37
Amoebiasis 38
12.02 IFNG IL10 IL1B TGFB2 TNF
38
Interleukin-4 and 13 signaling 67
12.01 CCL2 ICAM1 IL10 IL17A IL1B IL4
39
NF-kappa B signaling pathway 38
11.91 ICAM1 IL1B TNF
40
Glucocorticoid receptor regulatory network 1
11.91 ICAM1 IFNG IL2 IL4
41
Hematopoietic cell lineage 38
11.9 IL1B IL4 TNF
42
Visual Cycle in Retinal Rods 65
11.89 RBP3 RLBP1 SAG
43
TGF-beta signaling pathway (KEGG) 38
11.88 IFNG TGFB2 TNF
44
Dendritic Cells Developmental Lineage Pathway 66
11.88 IFNG IL10 IL1B IL2 TNF
45
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.87 IFNG IL2 IL4 TNF
46
Jak-Stat Signaling Pathway (sino) 68
11.86 IFNG IL10 IL2
47
Rheumatoid arthritis 38
11.82 CCL2 ICAM1 IFNG IL17A IL1B TGFB2
48
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.8 ICAM1 IFNG IL1B IL2 TNF
49
Pertussis 38
11.79 IL10 IL1B TNF
50
Lung fibrosis 1
11.78 CCL2 IL1B IL4 TNF
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GO Terms for Autoimmune Uveitis

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Cellular components related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CCL2 IFNG IL10 IL17A IL1B IL2
2 extracellular space GO:0005615 9.36 CCL2 ICAM1 IFNG IL10 IL17A IL1B

Biological processes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 CCL2 IL10 IL17A IL1B TNF
2 cell-cell signaling GO:0007267 9.96 IL17A IL1B IL2 TGFB2
3 MAPK cascade GO:0000165 9.96 CCL2 IL1B IL2 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.92 IFNG IL1B IL2 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 IL10 IL1B TNF
6 response to drug GO:0042493 9.88 ICAM1 IL10 TGFB2
7 neutrophil chemotaxis GO:0030593 9.87 CCL2 IL1B TGFB2
8 cellular response to interleukin-1 GO:0071347 9.87 CCL2 ICAM1 IL17A
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 CCL2 ICAM1 TNF
10 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 IL1B TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 IFNG IL2 IL4
12 regulation of insulin secretion GO:0050796 9.84 IFNG IL1B TNF
13 positive regulation of T cell proliferation GO:0042102 9.83 IL1B IL2 IL4
14 humoral immune response GO:0006959 9.81 CCL2 IFNG TNF
15 cellular response to lipopolysaccharide GO:0071222 9.77 CCL2 ICAM1 IL10 IL1B TNF
16 extrinsic apoptotic signaling pathway GO:0097191 9.76 IFNG TGFB2 TNF
17 immune response GO:0006955 9.76 CCL2 IFNG IL10 IL17A IL1B IL2
18 positive regulation of interferon-gamma production GO:0032729 9.75 IL1B IL2 TNF
19 positive regulation of T cell differentiation GO:0045582 9.72 IL2 IL4
20 embryonic digestive tract development GO:0048566 9.72 TGFB2 TNF
21 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
22 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B TNF
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
24 regulation of regulatory T cell differentiation GO:0045589 9.71 IFNG IL2
25 response to ethanol GO:0045471 9.71 ICAM1 IL2
26 negative regulation of growth of symbiont in host GO:0044130 9.71 IL10 TNF
27 positive regulation of isotype switching to IgG isotypes GO:0048304 9.7 IL2 IL4
28 protein kinase B signaling GO:0043491 9.7 CCL2 IL1B TNF
29 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
30 negative regulation of endothelial cell apoptotic process GO:2000352 9.69 ICAM1 IL10 IL4
31 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
32 positive regulation of MHC class II biosynthetic process GO:0045348 9.67 IL10 IL4
33 regulation of establishment of endothelial barrier GO:1903140 9.67 IL1B TNF
34 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TNF
35 response to glucocorticoid GO:0051384 9.66 IL10 TNF
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
37 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 ICAM1 TNF
38 positive regulation of neuroinflammatory response GO:0150078 9.64 IL1B TNF
39 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
40 positive regulation of osteoclast differentiation GO:0045672 9.63 IFNG IL17A TNF
41 positive regulation of interleukin-23 production GO:0032747 9.62 IFNG IL17A
42 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 ICAM1 IFNG IL1B TNF
43 regulation of isotype switching GO:0045191 9.61 IL10 IL4
44 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG IL1B TNF
45 sequestering of triglyceride GO:0030730 9.6 IL1B TNF
46 type 2 immune response GO:0042092 9.59 IL10 IL4
47 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
48 negative regulation of alkaline phosphatase activity GO:0010693 9.56 TGFB2 TNF
49 cytokine-mediated signaling pathway GO:0019221 9.56 CCL2 ICAM1 IL10 IL17A IL1B IL2
50 receptor biosynthetic process GO:0032800 9.55 IL10 TNF

Molecular functions related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL2 IFNG IL10 IL17A IL1B IL2
2 retinol binding GO:0019841 9.26 RBP3 RLBP1
3 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 TGFB2
4 retinal binding GO:0016918 9.16 RBP3 RLBP1
Sources

Sources for Autoimmune Uveitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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