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MCID: ATM099
MIFTS: 51

Autoimmune Uveitis

Categories: Eye diseases, Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Autoimmune Uveitis

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MalaCards integrated aliases for Autoimmune Uveitis:

Name: Autoimmune Uveitis 12 15

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Immune diseases Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040088
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Summaries for Autoimmune Uveitis

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Disease Ontology : 12 An autoimmune disease of eyes, ear, nose and throat that is located in the uvea.

MalaCards based summary : Autoimmune Uveitis is related to choroiditis and posterior uveitis. An important gene associated with Autoimmune Uveitis is RBP3 (Retinol Binding Protein 3), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Mycophenolic acid and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include the uvea, t cells and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Autoimmune Uveitis

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Diseases in the Uveitis family:

Autoimmune Uveitis Posterior Uveitis
Intermediate Uveitis Infectious Anterior Uveitis
Anterior Uveitis Infectious Posterior Uveitis

Diseases related to Autoimmune Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 291)
# Related Disease Score Top Affiliating Genes
1 choroiditis 30.2 IL10 TNF
2 posterior uveitis 29.4 CAPN5 IFNG IL2 RBP3 SAG TNF
3 uveitis 28.7 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
4 autoimmune disease 28.2 IFNG IL10 IL17A IL1B IL2 IL4
5 variola major 10.5 IFNG IL2
6 berylliosis 10.5 IFNG IL2
7 fixed drug eruption 10.5 IFNG IL2
8 toxicodendron dermatitis 10.5 ICAM1 IL2
9 cephalosporin allergy 10.4 IFNG IL10
10 sporotrichosis 10.4 IFNG IL10
11 autoimmune enteropathy 10.4 ICAM1 IL17A
12 acute zonal occult outer retinopathy 10.4 RLBP1 SAG
13 neurosyphilis 10.4 IL10 IL17A
14 autoimmune myocarditis 10.4 IFNG TNF
15 farmer's lung 10.4 IL2 TNF
16 chronic beryllium disease 10.4 IFNG TNF
17 oral tuberculosis 10.4 IL2 TNF
18 streptococcal toxic-shock syndrome 10.4 IL2 TNF
19 shwartzman phenomenon 10.4 ICAM1 TNF
20 b-cell growth factor 10.3 IFNG IL4
21 penicillin allergy 10.3 IFNG IL4
22 cow milk allergy 10.3 IL10 TNF
23 trichuriasis 10.3 IL10 TNF
24 transient hypogammaglobulinemia 10.3 IL10 TNF
25 idiopathic achalasia 10.3 IL10 TNF
26 multifocal choroiditis 10.3 IL10 TNF
27 punctate inner choroidopathy 10.3 IL10 TNF
28 virus associated hemophagocytic syndrome 10.3 IL2 IL4
29 jak3-deficient severe combined immunodeficiency 10.3 IL2 IL4
30 fundus albipunctatus 10.3 RBP3 RLBP1 SAG
31 autoimmune disease of endocrine system 10.3 ICAM1 IFNG IL2
32 retinitis pigmentosa 22 10.3 IL10 IL4
33 preretinal fibrosis 10.3 RLBP1 TGFB2
34 herpes zoster 10.3 IFNG IL10 IL2
35 focal segmental glomerulosclerosis 1 10.3 ICAM1 IL1B
36 uremic pruritus 10.3 IL1B IL2
37 candidiasis 10.2 IFNG IL10 IL17A
38 mumps 10.2 IFNG IL2 TNF
39 hypersensitivity reaction type iv disease 10.2 IFNG IL2 TNF
40 smallpox 10.2 IFNG IL2 TNF
41 onchocerciasis 10.2 IL2 IL4 RBP3
42 melioidosis 10.2 IFNG IL10 TNF
43 dengue hemorrhagic fever 10.2 IFNG IL10 TNF
44 hemophagocytic lymphohistiocytosis 10.2 IFNG IL10 TNF
45 cutaneous t cell lymphoma 10.2 IFNG IL2 IL4
46 kashin-beck disease 10.2 IL1B TNF
47 burns 10.2 IL1B TNF
48 hepatitis a 10.2 IFNG IL10 TNF
49 hashimoto thyroiditis 10.2 ICAM1 IFNG IL4
50 mixed connective tissue disease 10.2 IFNG IL10 TNF

Graphical network of the top 20 diseases related to Autoimmune Uveitis:



Diseases related to Autoimmune Uveitis
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Symptoms & Phenotypes for Autoimmune Uveitis

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GenomeRNAi Phenotypes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.7 ICAM1 IL10 IL17A IL1B IL2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.7 ICAM1 IL10 IL17A IL1B IL2 TNF

MGI Mouse Phenotypes related to Autoimmune Uveitis:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.25 CAPN5 ICAM1 IFNG IL10 IL17A IL1B
2 immune system MP:0005387 10.23 CAPN5 CCL2 ICAM1 IFNG IL10 IL17A
3 homeostasis/metabolism MP:0005376 10.22 ICAM1 IFNG IL10 IL17A IL1B IL2
4 hematopoietic system MP:0005397 10.19 ICAM1 IFNG IL10 IL17A IL1B IL2
5 cardiovascular system MP:0005385 10.16 ICAM1 IFNG IL10 IL1B IL2 RLBP1
6 digestive/alimentary MP:0005381 10.14 ICAM1 IFNG IL10 IL17A IL2 IL4
7 mortality/aging MP:0010768 10.14 CAPN5 ICAM1 IFNG IL10 IL17A IL1B
8 endocrine/exocrine gland MP:0005379 10.13 ICAM1 IFNG IL10 IL17A IL2 IL4
9 craniofacial MP:0005382 10.09 IFNG IL10 IL17A IL1B IL4 TGFB2
10 nervous system MP:0003631 10.06 ICAM1 IFNG IL10 IL1B IL4 RBP3
11 integument MP:0010771 9.98 ICAM1 IFNG IL10 IL1B IL4 RLBP1
12 neoplasm MP:0002006 9.85 ICAM1 IFNG IL10 IL1B IL2 TNF
13 no phenotypic analysis MP:0003012 9.8 IFNG IL10 IL17A IL2 IL4 TNF
14 respiratory system MP:0005388 9.7 IFNG IL10 IL17A IL2 IL4 TGFB2
15 skeleton MP:0005390 9.56 IFNG IL10 IL17A IL1B IL4 RLBP1
16 vision/eye MP:0005391 9.32 ICAM1 IFNG IL10 IL2 IL4 RBP3
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Drugs & Therapeutics for Autoimmune Uveitis

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Drugs for Autoimmune Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved 24280-93-1 446541
2
Curcumin Approved, Experimental, Investigational Early Phase 1 458-37-7 969516
3
Methotrexate Approved 1959-05-2, 59-05-2 126941
4
Chlorambucil Approved 305-03-3 2708
5
Adalimumab Approved 331731-18-1 16219006
6
Cyclophosphamide Approved, Investigational 6055-19-2, 50-18-0 2907
7
Sirolimus Approved, Investigational 53123-88-9 46835353 6436030 5284616
8
Azathioprine Approved 446-86-6 2265
9
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
10
Infliximab Approved 170277-31-3
11
Metformin Approved Not Applicable 657-24-9 14219 4091
12 Anti-Bacterial Agents
13 Anti-Infective Agents
14 Antibiotics, Antitubercular
15 Antitubercular Agents
16 Anti-Inflammatory Agents Early Phase 1,Not Applicable
17 Antimetabolites
18 Immunosuppressive Agents
19 Immunologic Factors
20 Alkylating Agents
21 Cyclosporins
22 Calcineurin Inhibitors
23 glucocorticoids Not Applicable
24 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
25 Hormone Antagonists Not Applicable
26 Hormones Not Applicable
27 Hypoglycemic Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mycophenolate Sodium (Myfortic®) in the Treatment of Corticosteroid-refractory Autoimmune Uveitis:Pilot Study Unknown status NCT01261169 Myfortic
2 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
3 Assessment of the Anti-inflammatory Effects of Norflo Oro in Acute Relapses of HLA-B27 Associated Autoimmune Uveitis Recruiting NCT03584724 Early Phase 1 Norflo Oro;Placebo for Norflo Oro
4 Treatment Outcome of Uveitis in Autoimmune Diseases Not yet recruiting NCT03886233 Corticosteroid Series
5 A Clinical Trial of Metformin to Decrease Glucocorticoids Side Effects in Patients With Autoimmune Uveitis Not yet recruiting NCT03525028 Not Applicable Metformin;Placebo

Search NIH Clinical Center for Autoimmune Uveitis

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Genetic Tests for Autoimmune Uveitis

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Anatomical Context for Autoimmune Uveitis

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The Foundational Model of Anatomy Ontology organs/tissues related to Autoimmune Uveitis:

20
The Uvea

MalaCards organs/tissues related to Autoimmune Uveitis:

42
T Cells, Eye, Retina, Pineal, Monocytes, Spleen, Liver
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Publications for Autoimmune Uveitis

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Articles related to Autoimmune Uveitis:

(show top 50) (show all 370)
# Title Authors Year
1
Evaluation of controlled-release triamcinolone acetonide-loaded mPEG-PLGA nanoparticles in treating experimental autoimmune uveitis. ( 30641491 )
2019
2
Clinical and Functional Evaluation of Ocular Inflammatory Disease Using the Model of Experimental Autoimmune Uveitis. ( 30649775 )
2019
3
Controlled release of corticosteroid with biodegradable nanoparticles for treating experimental autoimmune uveitis. ( 30660629 )
2019
4
Disruption of Intestinal Homeostasis and Intestinal Microbiota During Experimental Autoimmune Uveitis. ( 30695094 )
2019
5
Microbiome and Autoimmune Uveitis. ( 30837991 )
2019
6
AS101 ameliorates experimental autoimmune uveitis by regulating Th1 and Th17 responses and inducing Treg cells. ( 30853312 )
2019
7
Mesenchymal stem cells inhibited dendritic cells via the regulation of STAT1 and STAT6 phosphorylation in experimental autoimmune uveitis. ( 29424313 )
2018
8
Author Correction: Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. ( 29941876 )
2018
9
Total glucosides of paeony suppresses experimental autoimmune uveitis in association with inhibition of Th1 and Th2 cell function in mice. ( 29363368 )
2018
10
Targeting CD6 for the treatment of experimental autoimmune uveitis. ( 29472120 )
2018
11
The immunopathogenesis of chronic and relapsing autoimmune uveitis - Lessons from experimental rat models. ( 29496590 )
2018
12
Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis. ( 29572578 )
2018
13
Local S100A8 Levels Correlate With Recurrence of Experimental Autoimmune Uveitis and Promote Pathogenic T Cell Activity. ( 29625456 )
2018
14
Propolis modulates NOS2/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis. ( 29752572 )
2018
15
Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis. ( 30004859 )
2018
16
A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis. ( 30048621 )
2018
17
Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells. ( 30050530 )
2018
18
Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis. ( 30090104 )
2018
19
Subretinal Transplantation of Human Amniotic Epithelial Cells in the Treatment of Autoimmune Uveitis in Rats. ( 30168350 )
2018
20
TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations. ( 30218573 )
2018
21
Adenosine receptor activation in the Th17 autoimmune responses of experimental autoimmune uveitis. ( 30249343 )
2018
22
Dynamic DNA Methylation Changes of Tbx21 and Rorc during Experimental Autoimmune Uveitis in Mice. ( 30254507 )
2018
23
Commentary: Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells. ( 30498498 )
2018
24
Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro. ( 30510488 )
2018
25
CD83+ CCR7+ NK cells induced by interleukin 18 by dendritic cells promote experimental autoimmune uveitis. ( 30548211 )
2018
26
Comparative Analysis of the Interphotoreceptor Retinoid Binding ProteinInduced Models of Experimental Autoimmune Uveitis in B10.RIII versus C57BL/6 Mice. ( 30636608 )
2018
27
Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Decrease the Development of Severe Experimental Autoimmune Uveitis in B10.RIII Mice. ( 28914568 )
2017
28
Correction: Regulation of Adenosine Deaminase on Induced Mouse Experimental Autoimmune Uveitis. ( 28069759 )
2017
29
Functional Conversion and Dominance of I^I' T Subset in Mouse Experimental Autoimmune Uveitis. ( 28069804 )
2017
30
Preventive effect of chrysin on experimental autoimmune uveitis triggered by injection of human IRBP peptide 1-20 in mice. ( 26996065 )
2017
31
Formin like 1 expression is increased on CD4+ T lymphocytes in spontaneous autoimmune uveitis. ( 28057602 )
2017
32
Commensal microbiota as a potential trigger of autoimmune uveitis. ( 28145784 )
2017
33
Proteomic Profiling Analysis Reveals a Link between Experimental Autoimmune Uveitis and Complement Activation in Rats. ( 28199731 )
2017
34
Novel CD28 antagonist mPEG PV1-Fab' mitigates experimental autoimmune uveitis by suppressing CD4+ T lymphocyte activation and IFN-γ production. ( 28248972 )
2017
35
The HMGB1-CXCL12 Complex Promotes Inflammatory Cell Infiltration in Uveitogenic T Cell-Induced Chronic Experimental Autoimmune Uveitis. ( 28261206 )
2017
36
Intravitreal injection of anti-Interleukin (IL)-6 antibody attenuates experimental autoimmune uveitis in mice. ( 28267649 )
2017
37
Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. ( 28659587 )
2017
38
MHC class II expression and potential antigen-presenting cells in the retina during experimental autoimmune uveitis. ( 28720143 )
2017
39
Targeting interleukin-6 in autoimmune uveitis. ( 28778705 )
2017
40
Proteome Dynamics in Biobanked Horse Peripheral Blood Derived Lymphocytes (PBL) with Induced Autoimmune Uveitis. ( 28846213 )
2017
41
Behavioral Conditioning of Immune Responses with Cyclosporine A in a Murine Model of Experimental Autoimmune Uveitis. ( 28848192 )
2017
42
Complement Component C4 Regulates the Development of Experimental Autoimmune Uveitis through a T Cell-Intrinsic Mechanism. ( 28955337 )
2017
43
NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis. ( 29038541 )
2017
44
Ly6Chi monocytes are required for mesenchymal stem/stromal cell-induced immune tolerance in mice with experimental autoimmune uveitis. ( 29056505 )
2017
45
Gut microbiota linked to autoimmune uveitis. ( 30310875 )
2017
46
Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). ( 27196432 )
2016
47
The Role of Interleukin-22 and Its Receptor in the Development and Pathogenesis of Experimental Autoimmune Uveitis. ( 27166675 )
2016
48
Notch signalling suppresses regulatory T-cell function in murine experimental autoimmune uveitis. ( 27564686 )
2016
49
Digoxin Inhibits Induction of Experimental Autoimmune Uveitis in Mice, but Causes Severe Retinal Degeneration. ( 27028065 )
2016
50
Autoimmune uveitis: clinical, pathogenetic, and therapeutic features. ( 25820692 )
2016
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Variations for Autoimmune Uveitis

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Expression for Autoimmune Uveitis

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Search GEO for disease gene expression data for Autoimmune Uveitis.
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Pathways for Autoimmune Uveitis

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Pathways related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 65
Show member pathways
 13.85 CAPN5 CCL2 IL10 IL17A IL1B IL2
2
PEDF Induced Signaling 65
Show member pathways
 13.7 CCL2 IFNG IL10 IL17A IL1B IL2
3
TGF-Beta Pathway 65
Show member pathways
 13.59 CCL2 ICAM1 IFNG IL10 IL17A IL1B
4
Akt Signaling 65
Show member pathways
 13.44 CCL2 IL10 IL17A IL1B IL2 IL4
5
Cytokine Signaling in Immune system 67
Show member pathways
 13.43 CCL2 ICAM1 IFNG IL10 IL17A IL1B
6
PAK Pathway 65
Show member pathways
 13.36 CCL2 IL10 IL17A IL1B IL2 IL4
7
Toll-like Receptor Signaling Pathway 38 1
Show member pathways
 13.26 CCL2 IFNG IL10 IL1B IL2 TGFB2
8
Allograft rejection 1 38
Show member pathways
 12.96 ICAM1 IFNG IL10 IL17A IL1B IL2
9
Human cytomegalovirus infection 38
Show member pathways
 12.94 CCL2 ICAM1 IL1B TGFB2 TNF
10
Influenza A 38
Show member pathways
 12.68 CCL2 ICAM1 IFNG IL1B IL2 IL4
11
Immune response IL-23 signaling pathway 23
Show member pathways
 12.68 CCL2 IFNG IL10 IL17A IL1B IL2
12
Immune response NFAT in immune response 23
Show member pathways
 12.67 IFNG IL10 IL2 IL4 TNF
13
Th17 cell differentiation 38
Show member pathways
 12.66 IFNG IL10 IL17A IL1B IL2 IL4
14
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.58 ICAM1 IFNG IL2 IL4 TNF
15
T cell receptor signaling pathway 38
Show member pathways
 12.53 IFNG IL10 IL17A IL1B IL2 IL4
16
NF-kappaB Signaling 4
12.49 CCL2 IFNG IL10 IL17A IL1B IL2
17
IL-17 Family Signaling Pathways 66
Show member pathways
 12.45 CCL2 IFNG IL17A IL1B IL4 TNF
18
Selenium Micronutrient Network 1
Show member pathways
 12.45 CCL2 ICAM1 IFNG IL1B IL2 IL4
19
JAK-STAT signaling pathway (KEGG) 66
Show member pathways
 12.4 IFNG IL10 IL2 IL4
20
Human T-cell leukemia virus 1 infection 38
12.37 ICAM1 IL2 TGFB2 TNF
21
Toxoplasmosis 38
Show member pathways
 12.37 IFNG IL10 IL1B IL4 TGFB2 TNF
22
Tuberculosis 38
12.33 IFNG IL10 IL1B TGFB2 TNF
23
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.32 IFNG IL10 IL17A IL1B IL2 IL4
24
C-type lectin receptor signaling pathway 38
Show member pathways
 12.26 IL10 IL1B IL2 TNF
25
Bacterial infections in CF airways 23
Show member pathways
 12.24 IFNG IL1B IL4 TNF
26
Fluid shear stress and atherosclerosis 38
12.21 CCL2 ICAM1 IFNG IL1B TNF
27
Th1 Differentiation Pathway 66
Show member pathways
 12.15 IFNG IL10 IL17A IL1B IL2 TGFB2
28
Osteoclast differentiation 38
12.12 IFNG IL1B TGFB2 TNF
29
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
12.12 IFNG IL10 IL2 IL4 TNF
30
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 12.11 IFNG IL1B IL4 TNF
31
Spinal Cord Injury 1
12.1 CCL2 ICAM1 IFNG IL1B IL2 IL4
32
Immune response IFN gamma signaling pathway 23
Show member pathways
 12.07 CCL2 ICAM1 IFNG IL10 IL17A IL1B
33
IL12-mediated signaling events 1
Show member pathways
 12.05 IFNG IL1B IL2 IL4
34
TNF signaling pathway 38
12.04 CCL2 ICAM1 IL1B TNF
35
AGE-RAGE signaling pathway in diabetic complications 38
12.04 CCL2 ICAM1 IL1B TGFB2 TNF
36
Interleukin-4 and 13 signaling 67
12.03 CCL2 ICAM1 IL10 IL17A IL1B IL4
37
Amoebiasis 38
12.02 IFNG IL10 IL1B TGFB2 TNF
38
Glucocorticoid receptor regulatory network 1
11.91 ICAM1 IFNG IL2 IL4
39
Hematopoietic cell lineage 38
11.9 IL1B IL4 TNF
40
Visual Cycle in Retinal Rods 65
11.89 RBP3 RLBP1 SAG
41
NF-kappa B signaling pathway 38
11.89 ICAM1 IL1B TNF
42
Dendritic Cells Developmental Lineage Pathway 66
11.88 IFNG IL10 IL1B IL2 TNF
43
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.87 IFNG IL2 IL4 TNF
44
Rheumatoid arthritis 38
11.87 CCL2 ICAM1 IFNG IL17A IL1B TGFB2
45
Jak-Stat Signaling Pathway (sino) 68
11.86 IFNG IL10 IL2
46
TGF-beta signaling pathway (KEGG) 38
11.86 IFNG TGFB2 TNF
47
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.8 ICAM1 IFNG IL1B IL2 TNF
48
Pertussis 38
11.79 IL10 IL1B TNF
49
Lung fibrosis 1
11.78 CCL2 IL1B IL4 TNF
50
Innate Lymphoid Cell Differentiation Pathways 66
11.7 IFNG IL10 IL17A IL1B IL2 IL4
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GO Terms for Autoimmune Uveitis

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Cellular components related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CCL2 IFNG IL10 IL17A IL1B IL2
2 extracellular space GO:0005615 9.36 CCL2 ICAM1 IFNG IL10 IL17A IL1B

Biological processes related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.97 IL17A IL1B IL2 TGFB2
2 inflammatory response GO:0006954 9.97 CCL2 IL10 IL17A IL1B TNF
3 MAPK cascade GO:0000165 9.96 CCL2 IL1B IL2 TNF
4 positive regulation of protein phosphorylation GO:0001934 9.92 IFNG IL1B IL2 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 IL10 IL1B TNF
6 response to drug GO:0042493 9.88 ICAM1 IL10 TGFB2
7 neutrophil chemotaxis GO:0030593 9.87 CCL2 IL1B TGFB2
8 cellular response to interleukin-1 GO:0071347 9.87 CCL2 ICAM1 IL17A
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 CCL2 ICAM1 TNF
10 cellular response to organic cyclic compound GO:0071407 9.85 CCL2 IL1B TNF
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 IFNG IL2 IL4
12 regulation of insulin secretion GO:0050796 9.85 IFNG IL1B TNF
13 positive regulation of T cell proliferation GO:0042102 9.83 IL1B IL2 IL4
14 humoral immune response GO:0006959 9.81 CCL2 IFNG TNF
15 cellular response to lipopolysaccharide GO:0071222 9.77 CCL2 ICAM1 IL10 IL1B TNF
16 extrinsic apoptotic signaling pathway GO:0097191 9.76 IFNG TGFB2 TNF
17 immune response GO:0006955 9.76 CCL2 IFNG IL10 IL17A IL1B IL2
18 positive regulation of interferon-gamma production GO:0032729 9.75 IL1B IL2 TNF
19 protein kinase B signaling GO:0043491 9.73 CCL2 IL1B TNF
20 embryonic digestive tract development GO:0048566 9.72 TGFB2 TNF
21 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
22 positive regulation of glial cell proliferation GO:0060252 9.71 IL1B TNF
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
24 response to ethanol GO:0045471 9.71 ICAM1 IL2
25 regulation of regulatory T cell differentiation GO:0045589 9.71 IFNG IL2
26 negative regulation of growth of symbiont in host GO:0044130 9.7 IL10 TNF
27 positive regulation of isotype switching to IgG isotypes GO:0048304 9.7 IL2 IL4
28 negative regulation of endothelial cell apoptotic process GO:2000352 9.69 ICAM1 IL10 IL4
29 endothelial cell apoptotic process GO:0072577 9.68 IL10 TNF
30 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL1B TNF
31 response to glucocorticoid GO:0051384 9.67 IL10 TNF
32 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 CCL2 IL1B TNF
33 positive regulation of MHC class II biosynthetic process GO:0045348 9.66 IL10 IL4
34 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
35 negative regulation of cytokine secretion involved in immune response GO:0002740 9.65 IL10 TNF
36 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.64 ICAM1 TNF
37 positive regulation of neuroinflammatory response GO:0150078 9.64 IL1B TNF
38 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
39 positive regulation of osteoclast differentiation GO:0045672 9.63 IFNG IL17A TNF
40 positive regulation of interleukin-23 production GO:0032747 9.62 IFNG IL17A
41 positive regulation of nitric oxide biosynthetic process GO:0045429 9.62 ICAM1 IFNG IL1B TNF
42 regulation of isotype switching GO:0045191 9.61 IL10 IL4
43 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG IL1B TNF
44 sequestering of triglyceride GO:0030730 9.6 IL1B TNF
45 type 2 immune response GO:0042092 9.59 IL10 IL4
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 IL10 IL1B TNF
47 cytokine-mediated signaling pathway GO:0019221 9.56 CCL2 ICAM1 IL10 IL17A IL1B IL2
48 negative regulation of alkaline phosphatase activity GO:0010693 9.55 TGFB2 TNF
49 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
50 regulation of complement-dependent cytotoxicity GO:1903659 9.52 IL10 TGFB2

Molecular functions related to Autoimmune Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 CCL2 IFNG IL10 IL17A IL1B IL2
2 retinol binding GO:0019841 9.26 RBP3 RLBP1
3 growth factor activity GO:0008083 9.26 IL10 IL2 IL4 TGFB2
4 retinal binding GO:0016918 9.16 RBP3 RLBP1
Sources

Sources for Autoimmune Uveitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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