MCID: ATM104
MIFTS: 33

Autoimmune Vasculitis

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Autoimmune Vasculitis

MalaCards integrated aliases for Autoimmune Vasculitis:

Name: Autoimmune Vasculitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040097
UMLS 72 C1328843

Summaries for Autoimmune Vasculitis

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by inflammation of the blood vessels.

MalaCards based summary : Autoimmune Vasculitis is related to autoimmune disease and papillon-lefevre syndrome. An important gene associated with Autoimmune Vasculitis is SEMA4D (Semaphorin 4D), and among its related pathways/superpathways are Th17 cell differentiation and NF-kappaB Signaling. Affiliated tissues include neutrophil, endothelial and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Vasculitis

Diseases in the Vasculitis family:

Autoimmune Vasculitis Secondary Vasculitis

Diseases related to Autoimmune Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 autoimmune disease 30.2 IL4 IL2 IL1B
2 papillon-lefevre syndrome 29.3 ELANE CTSG
3 systemic lupus erythematosus 27.6 IL4 IL2 IL1B ELANE CTSG
4 vasculitis 11.8
5 uremic pruritus 10.4 IL2 IL1B
6 crohn's colitis 10.4 IL2 IL1B
7 wells syndrome 10.4 IL2 IL1B
8 diversion colitis 10.4 IL4 IL1B
9 opisthorchiasis 10.4 IL4 IL1B
10 commensal bacterial infectious disease 10.4 IL2 IL1B
11 virus associated hemophagocytic syndrome 10.4 IL4 IL2
12 eales disease 10.4 IL4 IL1B
13 jak3-deficient severe combined immunodeficiency 10.4 IL4 IL2
14 primary systemic mycosis 10.3 IL4 IL1B
15 atopic keratoconjunctivitis 10.3 IL4 IL2
16 keratoconjunctivitis 10.3 IL4 IL2
17 conjunctivitis 10.3 IL4 IL2
18 angiostrongyliasis 10.3 IL4 IL2
19 prostatitis 10.3 IL2 IL1B
20 gaucher disease, type ii 10.3 IL4 IL2
21 vulvovaginal candidiasis 10.3 IL4 IL2
22 q fever 10.3 IL4 IL1B
23 coccidiosis 10.3 IL4 IL2
24 extrinsic cardiomyopathy 10.3 IL4 IL1B
25 severe combined immunodeficiency, x-linked 10.3 IL4 IL2
26 keratoconjunctivitis sicca 10.3 IL4 IL1B
27 vernal conjunctivitis 10.3 IL4 IL2
28 acute graft versus host disease 10.3 IL4 IL2
29 somatoform disorder 10.3 IL4 IL1B
30 endogenous depression 10.3 IL2 IL1B
31 onchocerciasis 10.3 IL4 IL2
32 intervertebral disc disease 10.2 IL2 IL1B
33 paracoccidioidomycosis 10.2 IL4 IL2
34 neuritis 10.2 IL4 IL1B
35 lymphangiosarcoma 10.2 IL2 ESAM
36 parasitic helminthiasis infectious disease 10.2 IL4 IL2
37 brucellosis 10.2 IL4 IL2
38 farmer's lung 10.2 IL2 ELANE
39 allergic contact dermatitis 10.2 IL4 IL1B
40 gingival disease 10.2 IL1B ELANE
41 autoimmune disease of musculoskeletal system 10.2 IL4 IL2
42 central nervous system tuberculosis 10.2 IL1B ELANE
43 contact dermatitis 10.2 IL4 IL1B
44 capillary leak syndrome 10.2 IL2 ELANE
45 aggressive periodontitis 10.2 IL4 IL1B
46 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
47 upper respiratory tract disease 10.1 IL4 IL1B
48 acute respiratory distress syndrome 10.1 IL1B ELANE
49 anca-associated vasculitis 10.1
50 newborn respiratory distress syndrome 10.1 IL1B ELANE

Graphical network of the top 20 diseases related to Autoimmune Vasculitis:



Diseases related to Autoimmune Vasculitis

Symptoms & Phenotypes for Autoimmune Vasculitis

MGI Mouse Phenotypes related to Autoimmune Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CTSG ELANE ESAM IL1B IL2 IL4
2 immune system MP:0005387 9.5 CTSG ELANE ESAM IL1B IL2 IL4
3 neoplasm MP:0002006 9.02 CTSG ELANE ESAM IL1B IL2

Drugs & Therapeutics for Autoimmune Vasculitis

Search Clinical Trials , NIH Clinical Center for Autoimmune Vasculitis

Genetic Tests for Autoimmune Vasculitis

Anatomical Context for Autoimmune Vasculitis

MalaCards organs/tissues related to Autoimmune Vasculitis:

41
Neutrophil, Endothelial, T Cells, Testes, Brain, Smooth Muscle, Heart

Publications for Autoimmune Vasculitis

Articles related to Autoimmune Vasculitis:

(show top 50) (show all 165)
# Title Authors PMID Year
1
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance. 38
31142442 2019
2
Extracellular vesicles in autoimmune vasculitis - Little dirts light the fire in blood vessels. 38
30959208 2019
3
Multiple Overlapping Stent Implantation Combined with Coil Embolization for a Suprarenal Aortic Pseudoaneurysm with Impending Rupture in a Patient with Behçet's Disease. 38
31075471 2019
4
Predisposing factors of childhood Henoch-Schönlein purpura in Anhui province, China. 38
30530785 2019
5
Neuroimmunological response in neuro-Behçet's. 38
28359764 2019
6
Ocular Manifestations of Granulomatosis with Polyangiitis. 38
31234629 2019
7
Autoimmune diseases are associated with an increased risk of schizophrenia: A nationwide population-based cohort study. 38
29925476 2018
8
Sudden unilateral vision loss in an adult with Behcet disease: A case report. 38
30558031 2018
9
Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis? 38
29648680 2018
10
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. 38
29925593 2018
11
Antiglomerular Basement Membrane Disease. 38
30404116 2018
12
Rituximab treatment in primary angiitis of the central nervous system. 38
29898271 2018
13
A rare case of mitral valve dissection and aortic-left ventricular tunnel associated with possible autoimmune vasculitis. 38
29756686 2018
14
Low dose IL-2 increase regulatory T cells and elevate platelets in a patient with immune thrombocytopenia. 38
27862977 2018
15
A case report: incomplete Kawasaki disease in a hypogammaglobulinémie child. 38
29557626 2018
16
Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease? 38
28495524 2018
17
Systemic autoimmune diseases are associated with an increased risk of bipolar disorder: A nationwide population-based cohort study. 38
29049933 2018
18
Marginal-Zone B-Cells Are Main Producers of IgM in Humans, and Are Reduced in Patients With Autoimmune Vasculitis. 38
30356862 2018
19
Checks and Balances in Autoimmune Vasculitis. 38
29520282 2018
20
Cerebrospinal Fluid Concentrations of Neuronal Proteins Are Reduced in Primary Angiitis of the Central Nervous System. 38
29922220 2018
21
Cutaneous Manifestations of ANCA-Associated Small Vessels Vasculitis. 38
28578472 2017
22
Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis. 38
29078325 2017
23
Testing anti-neutrophil cytoplasmic antibodies (ANCA): analysis of the European EASI survey on the daily practice of the French laboratories. 38
28958962 2017
24
Henoch-Schönlein Purpura With Testicular Necrosis: Sonographic Findings at the Onset, During Treatment, and at Follow-up. 38
28499760 2017
25
Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis. 38
28416516 2017
26
The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway. 38
28724574 2017
27
Survey of False-positive Reactivity of Latex Agglutination Test for Kala-azar (Katex) without Urine Sample Boiling Process in Autoimmune Patients. 38
28828323 2017
28
Autoimmune Encephalopathy for Psychiatrists: When to Suspect Autoimmunity and What to Do Next. 38
28545782 2017
29
Antibody Glycosylation Predicts Relapse in Autoimmune Vasculitis. 38
28202231 2017
30
[The Impact of Corticotherapy on the Diagnostic Yield of Stereotactic Biopsy in Patients with Brain Lymphoma]. 38
29271215 2017
31
Is there a role for TNFα blockade in ANCA-associated vasculitis and glomerulonephritis? 38
28391344 2017
32
[Abdominal symptoms necessitating surgical intervention as the initial presentation of Henoch-Schönlein purpura in children - case reports]. 38
27403905 2016
33
Toe Amputation After Minor Surgery in a Patient with Behçet's Disease: A Case Report. 38
26483163 2016
34
Laparoscopic Antireflux Surgery in Patients with Connective Tissue Diseases. 38
27027697 2016
35
Periodic Acid-Schiff Staining Parallels the Immunoreactivity Seen By Direct Immunofluorescence in Autoimmune Skin Diseases. 38
27114972 2016
36
A Case of Neuro-Behcet's Disease Presenting with Central Neurogenic Hyperventilation. 38
26965646 2016
37
Extracellular vesicles as mediators of vascular inflammation in kidney disease. 38
26981436 2016
38
PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling. 38
26531064 2016
39
Immune Complex-Induced, Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes Is Prevented with Decoy FcγReceptors. 38
27101012 2016
40
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis. 38
26436651 2015
41
Hemophagocytic Syndrome, an Uncommon Complication of Microscopic Polyangitis: A Case Report From Senegal. 38
26866006 2015
42
Role of Brain Perfusion SPECT with 99mTc HMPAO in the Assessment of Response to Drug Therapy in Patients with Autoimmune Vasculitis: A Prospective Study. 38
25973400 2015
43
Gaze palsy, hypogeusia and a probable association with miscarriage of pregnancy--the expanding clinical spectrum of non-opticospinal neuromyelitis optica spectrum disorders: a case report. 38
25888897 2015
44
Establishment of a vascular endothelial cell-reactive type II NKT cell clone from a rat model of autoimmune vasculitis. 38
25239132 2015
45
Qing Re Liang Xue Decoction Alleviates Hypercoagulability in Kawasaki Disease. 38
26557152 2015
46
Design of universal cancer vaccines using natural tumor vessel-specific antigens (SANTAVAC). 38
25714389 2015
47
Inflammation in arterial diseases. 38
25631520 2015
48
COGAN'S SYNDROME. 38
27373108 2015
49
Cryptococcus neoformans meningoencephalitis in a patient with polyarteritis nodosa. 38
24947767 2014
50
Rapid Resolution of Severe Myocardial Dysfunction in a Patient with Rheumatoid Arthritis by Intravenous Immunoglobulin and Steroid Treatment. 38
27122836 2014

Variations for Autoimmune Vasculitis

Expression for Autoimmune Vasculitis

Search GEO for disease gene expression data for Autoimmune Vasculitis.

Pathways for Autoimmune Vasculitis

Pathways related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 IL4 IL2 IL1B
2 12.24 IL4 IL2 IL1B
3
Show member pathways
12.21 IL4 IL2 IL1B
4
Show member pathways
11.94 IL4 IL2 IL1B
5
Show member pathways
11.94 IL4 IL2 IL1B
6
Show member pathways
11.76 IL4 IL2 IL1B
7 11.58 IL4 IL2 IL1B
8
Show member pathways
11.49 IL4 IL2 IL1B
9
Show member pathways
11.39 IL2 IL1B
10 11.38 IL4 IL1B
11 11.23 IL4 IL1B
12 11.23 IL4 IL2 IL1B
13 11.21 IL2 IL1B
14 11.17 IL4 IL2
15 11 IL4 IL2
16 10.98 IL4 IL2 IL1B
17 10.96 IL4 IL1B
18 10.82 IL4 IL2
19 10.77 IL4 IL2 IL1B
20 10.26 IL4 IL2 IL1B

GO Terms for Autoimmune Vasculitis

Cellular components related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 9.13 IL1B ELANE CTSG
2 extracellular space GO:0005615 9.1 SEMA4D IL4 IL2 IL1B ELANE CTSG

Biological processes related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.7 IL4 IL2 IL1B
2 leukocyte migration GO:0050900 9.63 IL1B ESAM ELANE
3 positive regulation of protein phosphorylation GO:0001934 9.61 SEMA4D IL2 IL1B
4 extracellular matrix disassembly GO:0022617 9.57 ELANE CTSG
5 antimicrobial humoral response GO:0019730 9.56 ELANE CTSG
6 positive regulation of interferon-gamma production GO:0032729 9.54 IL2 IL1B
7 response to lipopolysaccharide GO:0032496 9.54 IL1B ELANE CTSG
8 positive regulation of B cell proliferation GO:0030890 9.51 IL4 IL2
9 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.49 IL2 IL1B
10 defense response to fungus GO:0050832 9.48 ELANE CTSG
11 positive regulation of T cell differentiation GO:0045582 9.4 IL4 IL2
12 negative regulation of growth of symbiont in host GO:0044130 9.32 ELANE CTSG
13 positive regulation of isotype switching to IgG isotypes GO:0048304 9.26 IL4 IL2
14 response to heat GO:0009408 9.25 DNAJA2
15 positive regulation of immune response GO:0050778 9.16 ELANE CTSG
16 positive regulation of T cell proliferation GO:0042102 9.13 IL4 IL2 IL1B
17 immune response GO:0006955 9.02 SEMA4D IL4 IL2 IL1B CTSG

Molecular functions related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL4 IL2 IL1B

Sources for Autoimmune Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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