MCID: ATM104
MIFTS: 35

Autoimmune Vasculitis

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Autoimmune Vasculitis

MalaCards integrated aliases for Autoimmune Vasculitis:

Name: Autoimmune Vasculitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040097
UMLS 71 C1328843

Summaries for Autoimmune Vasculitis

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by inflammation of the blood vessels.

MalaCards based summary : Autoimmune Vasculitis is related to vasculitis and anca-associated vasculitis. An important gene associated with Autoimmune Vasculitis is PRTN3 (Proteinase 3), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. Affiliated tissues include t cells, bone and neutrophil, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Vasculitis

Diseases in the Vasculitis family:

Autoimmune Vasculitis Secondary Vasculitis

Diseases related to Autoimmune Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 439)
# Related Disease Score Top Affiliating Genes
1 vasculitis 32.5 TNF PRTN3 MPO ELANE
2 anca-associated vasculitis 30.9 PRTN3 MPO
3 glomerulonephritis 30.2 PRTN3 MPO IL1B ELANE
4 rapidly progressive glomerulonephritis 29.9 PRTN3 MPO ELANE
5 papillon-lefevre syndrome 29.8 SPINK5 PRTN3 ELANE
6 silicosis 29.7 TNF IL4 IL1B
7 microscopic polyangiitis 29.5 TNF MPO FCGR2A
8 appendicitis 29.4 TNF MPO IL2 IL1B
9 systemic scleroderma 29.1 TNF IL4 H2AC18 CD4 CCR6
10 autoimmune disease 29.0 TNF PRTN3 IL4 IL2 IL1B FCGR2A
11 allergic hypersensitivity disease 28.9 TNF IL4 IL2 H2AC18 CD4 CCR6
12 connective tissue disease 28.3 TNF IL4 IL2 IL1B H2AC18 CD4
13 granulomatosis with polyangiitis 28.3 TNF SPINK5 PRTN3 MPO ELANE CD4
14 asthma 27.1 TNF SPINK5 MPO IL4 IL2 IL1B
15 systemic lupus erythematosus 26.7 TNF PRTN3 MPO IL4 IL2 IL1B
16 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.5 IL4 IL2
17 virus associated hemophagocytic syndrome 10.5 IL4 IL2
18 jak3-deficient severe combined immunodeficiency 10.5 IL4 IL2
19 atopic keratoconjunctivitis 10.5 IL4 IL2
20 uremic pruritus 10.5 IL2 IL1B
21 multiple cranial nerve palsy 10.4 PRTN3 MPO
22 pulmonary hemosiderosis 10.4 PRTN3 MPO
23 impetigo herpetiformis 10.4 PRTN3 ELANE
24 cicatricial entropion 10.4 PRTN3 MPO
25 caplan's syndrome 10.3 PRTN3 CD4
26 inflammatory bowel disease 18 10.3 IL4 IL2 CCR6
27 tropical endomyocardial fibrosis 10.3 TNF IL4
28 vulvovaginal candidiasis 10.3 IL4 IL2 CCR6
29 streptococcal toxic-shock syndrome 10.3 TNF IL2
30 subacute bacterial endocarditis 10.3 PRTN3 MPO
31 complement component 6 deficiency 10.3 MPO IL1B
32 posterior scleritis 10.3 TNF PRTN3
33 metal allergy 10.3 IL4 CD4
34 systemic onset juvenile idiopathic arthritis 10.3 TNF IL1B
35 staphylococcal toxic shock syndrome 10.3 TNF IL1B
36 nickel allergic contact dermatitis 10.3 IL4 CD4
37 toxicodendron dermatitis 10.3 TNF IL2
38 vulvar vestibulitis syndrome 10.3 TNF IL1B
39 palladium allergic contact dermatitis 10.3 TNF IL1B
40 kashin-beck disease 10.3 TNF IL1B
41 wissler's syndrome 10.3 PRTN3 CD4
42 vernal conjunctivitis 10.3 MPO IL4 CCR6
43 suppurative lymphadenitis 10.3 CD4 CCR6
44 yellow fever 10.2 IL4 IL1B CCR6
45 spongiotic dermatitis 10.2 CD4 CCR6
46 somatoform disorder 10.2 IL4 IL1B H2AC18
47 autoimmune inner ear disease 10.2 TNF MPO
48 endogenous depression 10.2 IL2 IL1B H2AC18
49 onchocerciasis 10.2 IL4 IL2 ELANE
50 felty syndrome 10.2 PRTN3 H2AC18 ELANE

Graphical network of the top 20 diseases related to Autoimmune Vasculitis:



Diseases related to Autoimmune Vasculitis

Symptoms & Phenotypes for Autoimmune Vasculitis

MGI Mouse Phenotypes related to Autoimmune Vasculitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CCR6 CD4 ELANE FCGR2A IL1B IL2
2 immune system MP:0005387 9.4 CCR6 CD4 ELANE FCGR2A IL1B IL2

Drugs & Therapeutics for Autoimmune Vasculitis

Search Clinical Trials , NIH Clinical Center for Autoimmune Vasculitis

Genetic Tests for Autoimmune Vasculitis

Anatomical Context for Autoimmune Vasculitis

MalaCards organs/tissues related to Autoimmune Vasculitis:

40
T Cells, Bone, Neutrophil, Lung, B Cells, Endothelial, Heart

Publications for Autoimmune Vasculitis

Articles related to Autoimmune Vasculitis:

(show top 50) (show all 173)
# Title Authors PMID Year
1
Relapsing Polychondritis with a Cobble-stone Appearance of the Tracheal Mucosa, Preceded by Posterior Reversible Encephalopathy Syndrome. 61
32009099 2020
2
Nontraumatic Subperiosteal Orbital Hematoma in a Patient With Behcet Disease. 61
31609957 2020
3
Recombinant thrombomodulin ameliorates autoimmune vasculitis via immune response regulation and tissue injury protection. 61
31883830 2019
4
Testicular tumour, could it be benign? A clinical conundrum. 61
31641592 2019
5
Plasma exchange in anti-glomerular basement membrane disease. 61
31703956 2019
6
The diagnosis and management of temporal arteritis. 61
31663193 2019
7
Multiple Overlapping Stent Implantation Combined with Coil Embolization for a Suprarenal Aortic Pseudoaneurysm with Impending Rupture in a Patient with Behçet's Disease. 61
31075471 2019
8
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance. 61
31142442 2019
9
A case of repetitive myocardial infarction with unobstructed coronaries due to Churg-Strauss syndrome. 61
31449602 2019
10
Extracellular vesicles in autoimmune vasculitis - Little dirts light the fire in blood vessels. 61
30959208 2019
11
Predisposing factors of childhood Henoch-Schönlein purpura in Anhui province, China. 61
30530785 2019
12
Neuroimmunological response in neuro-Behçet's. 61
28359764 2019
13
Ocular Manifestations of Granulomatosis with Polyangiitis. 61
31234629 2019
14
Assessment of T helper 17-associated cytokines in thromboangiitis obliterans. 61
31564950 2019
15
Autoimmune diseases are associated with an increased risk of schizophrenia: A nationwide population-based cohort study. 61
29925476 2018
16
Sudden unilateral vision loss in an adult with Behcet disease: A case report. 61
30558031 2018
17
Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis? 61
29648680 2018
18
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. 61
29925593 2018
19
Antiglomerular Basement Membrane Disease. 61
30404116 2018
20
Rituximab treatment in primary angiitis of the central nervous system. 61
29898271 2018
21
A rare case of mitral valve dissection and aortic-left ventricular tunnel associated with possible autoimmune vasculitis. 61
29756686 2018
22
Low dose IL-2 increase regulatory T cells and elevate platelets in a patient with immune thrombocytopenia. 61
27862977 2018
23
A case report: incomplete Kawasaki disease in a hypogammaglobulinémie child. 61
29557626 2018
24
Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease? 61
28495524 2018
25
Systemic autoimmune diseases are associated with an increased risk of bipolar disorder: A nationwide population-based cohort study. 61
29049933 2018
26
Marginal-Zone B-Cells Are Main Producers of IgM in Humans, and Are Reduced in Patients With Autoimmune Vasculitis. 61
30356862 2018
27
Checks and Balances in Autoimmune Vasculitis. 61
29520282 2018
28
Cerebrospinal Fluid Concentrations of Neuronal Proteins Are Reduced in Primary Angiitis of the Central Nervous System. 61
29922220 2018
29
Cutaneous Manifestations of ANCA-Associated Small Vessels Vasculitis. 61
28578472 2017
30
Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis. 61
29078325 2017
31
Testing anti-neutrophil cytoplasmic antibodies (ANCA): analysis of the European EASI survey on the daily practice of the French laboratories. 61
28958962 2017
32
Henoch-Schönlein Purpura With Testicular Necrosis: Sonographic Findings at the Onset, During Treatment, and at Follow-up. 61
28499760 2017
33
Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis. 61
28416516 2017
34
The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway. 61
28724574 2017
35
Survey of False-positive Reactivity of Latex Agglutination Test for Kala-azar (Katex) without Urine Sample Boiling Process in Autoimmune Patients. 61
28828323 2017
36
Autoimmune Encephalopathy for Psychiatrists: When to Suspect Autoimmunity and What to Do Next. 61
28545782 2017
37
Antibody Glycosylation Predicts Relapse in Autoimmune Vasculitis. 61
28202231 2017
38
Is there a role for TNFα blockade in ANCA-associated vasculitis and glomerulonephritis? 61
28391344 2017
39
[The Impact of Corticotherapy on the Diagnostic Yield of Stereotactic Biopsy in Patients with Brain Lymphoma]. 61
29271215 2017
40
[Abdominal symptoms necessitating surgical intervention as the initial presentation of Henoch-Schönlein purpura in children - case reports]. 61
27403905 2016
41
Toe Amputation After Minor Surgery in a Patient with Behçet's Disease: A Case Report. 61
26483163 2016
42
Laparoscopic Antireflux Surgery in Patients with Connective Tissue Diseases. 61
27027697 2016
43
Periodic Acid-Schiff Staining Parallels the Immunoreactivity Seen By Direct Immunofluorescence in Autoimmune Skin Diseases. 61
27114972 2016
44
A Case of Neuro-Behcet's Disease Presenting with Central Neurogenic Hyperventilation. 61
26965646 2016
45
Extracellular vesicles as mediators of vascular inflammation in kidney disease. 61
26981436 2016
46
Immune Complex-Induced, Nitric Oxide-Mediated Vascular Endothelial Cell Death by Phagocytes Is Prevented with Decoy FcγReceptors. 61
27101012 2016
47
PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling. 61
26531064 2016
48
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis. 61
26436651 2015
49
Hemophagocytic Syndrome, an Uncommon Complication of Microscopic Polyangitis: A Case Report From Senegal. 61
26866006 2015
50
Role of Brain Perfusion SPECT with 99mTc HMPAO in the Assessment of Response to Drug Therapy in Patients with Autoimmune Vasculitis: A Prospective Study. 61
25973400 2015

Variations for Autoimmune Vasculitis

Expression for Autoimmune Vasculitis

Search GEO for disease gene expression data for Autoimmune Vasculitis.

Pathways for Autoimmune Vasculitis

Pathways related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNF PRTN3 MPO IL4 IL2 IL1B
2
Show member pathways
13.19 TNF IL4 IL2 IL1B CD4 CCR6
3
Show member pathways
12.77 TNF IL4 IL2 IL1B CD4
4
Show member pathways
12.52 TNF IL4 IL2 IL1B CD4
5
Show member pathways
12.5 TNF IL4 IL2 IL1B CD4
6
Show member pathways
12.49 TNF MPO IL2 IL1B CD4
7 12.46 TNF MPO IL4 IL2 IL1B
8
Show member pathways
12.25 PRTN3 ELANE CD4 CCR6
9
Show member pathways
12.19 TNF IL4 IL1B FCGR2A
10
Show member pathways
12.19 TNF MPO IL4 IL2 IL1B
11
Show member pathways
12.16 TNF IL4 IL2 IL1B
12
Show member pathways
11.94 TNF IL2 IL1B CD4
13 11.91 TNF IL2 IL1B
14
Show member pathways
11.91 TNF IL4 IL1B FCGR2A
15 11.89 TNF IL4 IL1B
16
Show member pathways
11.85 IL4 IL2 IL1B CD4
17 11.8 TNF IL4 IL2 IL1B FCGR2A
18 11.77 TNF IL4 IL1B CD4
19
Show member pathways
11.7 TNF IL4 IL2
20 11.7 TNF MPO IL4 IL2 FCGR2A CD4
21 11.63 PRTN3 MPO ELANE CD4
22
Show member pathways
11.6 TNF IL2 IL1B
23 11.6 TNF IL4 IL1B
24 11.54 TNF IL2 IL1B CD4
25 11.51 TNF IL4 IL2 IL1B FCGR2A
26 11.47 TNF IL4 IL1B
27 11.46 TNF IL2 IL1B
28 11.45 TNF MPO ELANE
29 11.42 IL4 IL2 CD4
30 11.22 TNF IL4 IL1B
31 11 TNF IL4 IL2 IL1B CD4 CCR6
32 10.82 TNF IL4 IL2 IL1B CD4
33 10.78 TNF MPO IL1B

GO Terms for Autoimmune Vasculitis

Cellular components related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.7 SPIRE2 PIBF1 MPO IL2 ELANE CD4
2 extracellular region GO:0005576 9.61 TNF SPINK5 PRTN3 PIBF1 MPO IL4
3 secretory granule GO:0030141 9.5 MPO IL1B ELANE
4 azurophil granule lumen GO:0035578 9.43 PRTN3 MPO ELANE
5 extracellular space GO:0005615 9.28 TNF SEMA4D PRTN3 PIBF1 MPO IL4

Biological processes related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 9.73 TNF IL2 IL1B
2 positive regulation of protein phosphorylation GO:0001934 9.65 TNF SEMA4D IL2 IL1B CD4
3 negative regulation of lipid catabolic process GO:0050995 9.62 TNF IL1B
4 astrocyte activation GO:0048143 9.62 TNF IL1B
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 TNF PIBF1 IL4 IL2
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 TNF IL1B
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL1B
8 positive regulation of interferon-gamma production GO:0032729 9.61 TNF IL2 IL1B
9 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.6 TNF IL1B
10 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.59 IL1B CD4
11 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.58 TNF ELANE
12 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL1B
13 positive regulation of chemokine biosynthetic process GO:0045080 9.57 TNF IL1B
14 positive regulation of isotype switching to IgG isotypes GO:0048304 9.55 IL4 IL2
15 leukocyte migration involved in inflammatory response GO:0002523 9.54 ELANE CCR6
16 regulation of establishment of endothelial barrier GO:1903140 9.52 TNF IL1B
17 activation of Janus kinase activity GO:0042976 9.51 PIBF1 IL4
18 positive regulation of fever generation GO:0031622 9.49 TNF IL1B
19 sequestering of triglyceride GO:0030730 9.48 TNF IL1B
20 response to yeast GO:0001878 9.46 MPO ELANE
21 positive regulation of T cell proliferation GO:0042102 9.46 IL4 IL2 IL1B CD4
22 cytokine-mediated signaling pathway GO:0019221 9.43 TNF PRTN3 IL4 IL2 IL1B CD4
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 TNF IL1B
24 negative regulation of alkaline phosphatase activity GO:0010693 9.37 TNF SEMA4D
25 immune response GO:0006955 9.17 TNF SEMA4D IL4 IL2 IL1B CD4

Molecular functions related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL4 IL2 IL1B
2 interleukin-4 receptor binding GO:0005136 8.62 PIBF1 IL4

Sources for Autoimmune Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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