MCID: ATM104
MIFTS: 36

Autoimmune Vasculitis

Categories: Blood diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Autoimmune Vasculitis

MalaCards integrated aliases for Autoimmune Vasculitis:

Name: Autoimmune Vasculitis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040097
UMLS 74 C1328843

Summaries for Autoimmune Vasculitis

Disease Ontology : 12 An autoimmune disease of cardiovascular system that is characterized by inflammation of the blood vessels.

MalaCards based summary : Autoimmune Vasculitis is related to vasculitis and uremic pruritus. An important gene associated with Autoimmune Vasculitis is SEMA4D (Semaphorin 4D), and among its related pathways/superpathways are Th17 cell differentiation and NF-kappaB Signaling. Affiliated tissues include endothelial, lung and neutrophil, and related phenotypes are hematopoietic system and immune system

Related Diseases for Autoimmune Vasculitis

Diseases in the Vasculitis family:

Autoimmune Vasculitis

Diseases related to Autoimmune Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 vasculitis 11.7
2 uremic pruritus 10.2 IL1B IL2
3 crohn's colitis 10.2 IL1B IL2
4 wells syndrome 10.2 IL1B IL2
5 commensal bacterial infectious disease 10.2 IL1B IL2
6 diversion colitis 10.2 IL1B IL4
7 prostatitis 10.2 IL1B IL2
8 opisthorchiasis 10.2 IL1B IL4
9 primary systemic mycosis 10.2 IL1B IL4
10 eales disease 10.2 IL1B IL4
11 virus associated hemophagocytic syndrome 10.2 IL2 IL4
12 endogenous depression 10.2 IL1B IL2
13 jak3-deficient severe combined immunodeficiency 10.2 IL2 IL4
14 atopic keratoconjunctivitis 10.2 IL2 IL4
15 intervertebral disc disease 10.2 IL1B IL2
16 q fever 10.2 IL1B IL4
17 keratoconjunctivitis 10.2 IL2 IL4
18 conjunctivitis 10.2 IL2 IL4
19 angiostrongyliasis 10.2 IL2 IL4
20 gaucher disease, type ii 10.2 IL2 IL4
21 keratoconjunctivitis sicca 10.2 IL1B IL4
22 extrinsic cardiomyopathy 10.2 IL1B IL4
23 vulvovaginal candidiasis 10.1 IL2 IL4
24 coccidiosis 10.1 IL2 IL4
25 severe combined immunodeficiency, x-linked 10.1 IL2 IL4
26 somatoform disorder 10.1 IL1B IL4
27 vernal conjunctivitis 10.1 IL2 IL4
28 acute graft versus host disease 10.1 IL2 IL4
29 neuritis 10.1 IL1B IL4
30 onchocerciasis 10.1 IL2 IL4
31 allergic contact dermatitis 10.1 IL1B IL4
32 paracoccidioidomycosis 10.1 IL2 IL4
33 contact dermatitis 10.1 IL1B IL4
34 aggressive periodontitis 10.1 IL1B IL4
35 parasitic helminthiasis infectious disease 10.1 IL2 IL4
36 brucellosis 10.1 IL2 IL4
37 upper respiratory tract disease 10.1 IL1B IL4
38 gastroenteritis 10.1 IL1B IL4
39 autoimmune disease of musculoskeletal system 10.1 IL2 IL4
40 chronic fatigue syndrome 10.1 IL1B IL2
41 immune deficiency disease 10.1 IL2 IL4
42 leukocyte disease 10.1 IL2 IL4
43 chlamydia 10.1 IL1B IL4
44 visceral leishmaniasis 10.0 IL2 IL4
45 sezary's disease 10.0 IL2 IL4
46 toxoplasmosis 10.0 IL1B IL4
47 gingival disease 10.0 ELANE IL1B
48 central nervous system tuberculosis 10.0 ELANE IL1B
49 farmer's lung 10.0 ELANE IL2
50 capillary leak syndrome 10.0 ELANE IL2

Graphical network of the top 20 diseases related to Autoimmune Vasculitis:



Diseases related to Autoimmune Vasculitis

Symptoms & Phenotypes for Autoimmune Vasculitis

MGI Mouse Phenotypes related to Autoimmune Vasculitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 CTSG ELANE IL1B IL2 IL4 SEMA4D
2 immune system MP:0005387 9.43 CTSG ELANE IL1B IL2 IL4 SEMA4D
3 neoplasm MP:0002006 8.92 CTSG ELANE IL1B IL2

Drugs & Therapeutics for Autoimmune Vasculitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aetiology of TemporaL Arteritis Study Not yet recruiting NCT02584517

Search NIH Clinical Center for Autoimmune Vasculitis

Genetic Tests for Autoimmune Vasculitis

Anatomical Context for Autoimmune Vasculitis

MalaCards organs/tissues related to Autoimmune Vasculitis:

42
Endothelial, Lung, Neutrophil, Smooth Muscle, Brain, B Cells, Bone

Publications for Autoimmune Vasculitis

Articles related to Autoimmune Vasculitis:

(show all 35)
# Title Authors Year
1
Extracellular vesicles in autoimmune vasculitis - Little dirts light the fire in blood vessels. ( 30959208 )
2019
2
Checks and Balances in Autoimmune Vasculitis. ( 29520282 )
2018
3
A rare case of mitral valve dissection and aortic-left ventricular tunnel associated with possible autoimmune vasculitis. ( 29756686 )
2018
4
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis. ( 29925593 )
2018
5
Marginal-Zone B-Cells Are Main Producers of IgM in Humans, and Are Reduced in Patients With Autoimmune Vasculitis. ( 30356862 )
2018
6
Antibody Glycosylation Predicts Relapse in Autoimmune Vasculitis. ( 28202231 )
2017
7
Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis. ( 28416516 )
2017
8
Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis. ( 29078325 )
2017
9
Establishment of a vascular endothelial cell-reactive type II NKT cell clone from a rat model of autoimmune vasculitis. ( 25239132 )
2015
10
Role of Brain Perfusion SPECT with 99mTc HMPAO in the Assessment of Response to Drug Therapy in Patients with Autoimmune Vasculitis: A Prospective Study. ( 25973400 )
2015
11
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis. ( 26436651 )
2015
12
The role of first-pass perfusion deficit in the detection of cardiac subendocardial manifestation in patients with autoimmune vasculitis. ( 22212409 )
2013
13
Fetal outcomes after rituximab exposure in women with autoimmune vasculitis. ( 23864238 )
2013
14
Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis. ( 23138486 )
2012
15
Performance of the BioPlex 2200 Autoimmune Vasculitis kit. ( 18718876 )
2009
16
Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. ( 19264905 )
2009
17
An epistatic effect of the female specific loci on the development of autoimmune vasculitis and antinuclear autoantibody in murine lupus. ( 16150787 )
2006
18
Autoimmune vasculitis and plaque erosion in the cardiometabolic syndrome and type 2 diabetes mellitus. ( 17679803 )
2006
19
Antineutrophil cytoplasmic antibodies reacting with human neutrophil elastase as a diagnostic marker for cocaine-induced midline destructive lesions but not autoimmune vasculitis. ( 15457464 )
2004
20
Cochlear implants in systemic autoimmune vasculitis syndromes. ( 12211357 )
2002
21
The role of metals in autoimmune vasculitis: epidemiological and pathogenic study. ( 11327392 )
2001
22
Cytokines in experimental autoimmune vasculitis: evidence for a Th2 type response. ( 10544833 )
1999
23
Up-regulation of the granulocyte adhesion molecule Mac-1 by autoantibodies in autoimmune vasculitis. ( 9067526 )
1997
24
Autoimmune vasculitis and aortic stenosis in aspirin-induced asthma (AIA). ( 9140532 )
1997
25
Up-regulation of the endothelial cell adhesion molecule intercellular adhesion molecule-1 (ICAM-1) by autoantibodies in autoimmune vasculitis. ( 9158091 )
1997
26
Autoimmune vasculitis: a good clinical and basic exercise. ( 9209797 )
1997
27
Is there any pathogenic role for the anti-endothelial cell antibodies (AECA) in autoimmune vasculitis? ( 9582611 )
1997
28
Autoimmune vasculitis preceding aspirin-induced asthma. ( 7812172 )
1995
29
Autoantibody associations with MHC class II antigens in scleroderma and autoimmune vasculitis. ( 7578853 )
1994
30
Characterization of the endothelial surface proteins recognized by anti-endothelial antibodies in primary and secondary autoimmune vasculitis. ( 8313658 )
1994
31
Autoimmune vasculitis in MRL/Mp-lpr/lpr mice: orthochromatic basophils participate in the development of delayed-type hypersensitivity angiitis. ( 1343764 )
1992
32
Hemapheresis in treatment of systemic autoimmune vasculitis. ( 2352991 )
1990
33
Autoimmune vasculitis resulting from in vitro immunization of lymphocytes to smooth muscle. ( 4014434 )
1985
34
The role of vascular smooth muscle cells in experimental autoimmune vasculitis. I. The initiation of delayed type hypersensitivity angiitis. ( 6334445 )
1984
35
Experimental penile corporal (autoimmune) vasculitis in the rat. ( 5137333 )
1971

Variations for Autoimmune Vasculitis

Expression for Autoimmune Vasculitis

Search GEO for disease gene expression data for Autoimmune Vasculitis.

Pathways for Autoimmune Vasculitis

Pathways related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 IL1B IL2 IL4
2 12.21 IL1B IL2 IL4
3
Show member pathways
12.19 IL1B IL2 IL4
4
Show member pathways
11.94 IL1B IL2 IL4
5
Show member pathways
11.91 IL1B IL2 IL4
6
Show member pathways
11.76 IL1B IL2 IL4
7 11.58 IL1B IL2 IL4
8
Show member pathways
11.49 IL2 IL4
9
Show member pathways
11.49 IL1B IL2 IL4
10 11.47 IL1B IL2
11
Show member pathways
11.42 IL2 IL4
12 11.39 IL1B IL4
13
Show member pathways
11.38 IL1B IL2
14 11.24 IL1B IL4
15 11.23 IL1B IL2 IL4
16 11.22 IL1B IL2
17 11.17 IL2 IL4
18 11.01 IL2 IL4
19 10.98 IL1B IL2 IL4
20 10.96 IL1B IL4
21 10.85 IL2 IL4
22 10.77 IL1B IL2 IL4
23 10.26 IL1B IL2 IL4

GO Terms for Autoimmune Vasculitis

Cellular components related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 CTSG ELANE IL1B IL2 IL4
2 secretory granule GO:0030141 9.13 CTSG ELANE IL1B
3 extracellular space GO:0005615 9.1 CTSG ELANE IL1B IL2 IL4 SEMA4D

Biological processes related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.75 IL1B IL2 IL4
2 cytokine-mediated signaling pathway GO:0019221 9.67 IL1B IL2 IL4
3 positive regulation of protein phosphorylation GO:0001934 9.58 IL1B IL2 SEMA4D
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.57 IL2 IL4
5 extracellular matrix disassembly GO:0022617 9.56 CTSG ELANE
6 antimicrobial humoral response GO:0019730 9.55 CTSG ELANE
7 response to lipopolysaccharide GO:0032496 9.54 CTSG ELANE IL1B
8 positive regulation of interferon-gamma production GO:0032729 9.52 IL1B IL2
9 positive regulation of B cell proliferation GO:0030890 9.51 IL2 IL4
10 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.48 IL1B IL2
11 defense response to fungus GO:0050832 9.46 CTSG ELANE
12 positive regulation of T cell differentiation GO:0045582 9.43 IL2 IL4
13 negative regulation of growth of symbiont in host GO:0044130 9.32 CTSG ELANE
14 positive regulation of immune response GO:0050778 9.26 CTSG ELANE
15 response to heat GO:0009408 9.24 DNAJA2
16 positive regulation of isotype switching to IgG isotypes GO:0048304 9.16 IL2 IL4
17 positive regulation of T cell proliferation GO:0042102 9.13 IL1B IL2 IL4
18 immune response GO:0006955 9.02 CTSG IL1B IL2 IL4 SEMA4D

Molecular functions related to Autoimmune Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL1B IL2 IL4

Sources for Autoimmune Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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