Autonomic Dysfunction

Categories: Blood diseases, Neuronal diseases

Aliases & Classifications for Autonomic Dysfunction

MalaCards integrated aliases for Autonomic Dysfunction:

Name: Autonomic Dysfunction 53 6
Autonomic Nervous System Disorders 70
Autonomic Disorder 54


External Ids:

UMLS 70 C1145628

Summaries for Autonomic Dysfunction

NINDS : 53 Dysautonomia refers to a disorder of autonomic nervous system (ANS) function that generally involves failure of the sympathetic or parasympathetic components of the ANS, but dysautonomia involving excessive or overactive ANS actions also can occur. Dysautonomia can be local, as in reflex sympathetic dystrophy, or generalized, as in pure autonomic failure. It can be acute and reversible, as in Guillain-Barre syndrome, or chronic and progressive. Several common conditions such as diabetes and alcoholism can include dysautonomia. Dysautonomia also can occur as a primary condition or in association with degenerative neurological diseases such as Parkinson's disease. Other diseases with generalized, primary dysautonomia include multiple system atrophy and familial dysautonomia. Hallmarks of generalized dysautonomia due to sympathetic failure are impotence (in men) and a fall in blood pressure during standing (orthostatic hypotension). Excessive sympathetic activity can present as hypertension or a rapid pulse rate.

MalaCards based summary : Autonomic Dysfunction, also known as autonomic nervous system disorders, is related to neuronal intranuclear inclusion disease and neuropathy, hereditary sensory and autonomic, type iib, and has symptoms including seizures, tremor and constipation. An important gene associated with Autonomic Dysfunction is CPT2 (Carnitine Palmitoyltransferase 2), and among its related pathways/superpathways is Neuroscience. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and liver, and related phenotypes are nervous system and normal

Wikipedia : 73 Dysautonomia or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does... more...

Related Diseases for Autonomic Dysfunction

Diseases related to Autonomic Dysfunction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 603)
# Related Disease Score Top Affiliating Genes
1 neuronal intranuclear inclusion disease 32.0 SNCA NOTCH2NLC
2 neuropathy, hereditary sensory and autonomic, type iib 31.4 SCN9A RETREG1
3 multiple system atrophy 1 31.4 SNCA DBH
4 pure autonomic failure 31.2 SNCA DBH
5 dysautonomia 31.2 USH2A SNCA CPT2
6 autonomic nervous system disease 31.0 SCN9A PHOX2B DBH
7 tremor 30.3 SNCA NOTCH2NLC
8 peripheral nervous system disease 30.3 SNCA SCN9A PHOX2B
9 neuropathy, hereditary sensory and autonomic, type iii 30.2 RETREG1 DBH
10 megacolon 29.9 PHOX2B ECE1
11 central hypoventilation syndrome, congenital 29.9 PHOX2B ECE1 DBH
12 alcohol dependence 29.8 SNCA DBH CHRNA3
13 hirschsprung disease 1 29.8 PHOX2B ECE1 DBH
14 sensory peripheral neuropathy 29.7 SCN9A RETREG1
15 dopamine beta-hydroxylase deficiency 29.6 SNCA DBH
16 chronic pain 29.6 USH2A CPT2
17 hirschsprung disease, cardiac defects, and autonomic dysfunction 11.6
18 neuroleptic malignant syndrome 11.3
19 pitt-hopkins syndrome 11.3
20 autosomal dominant leukodystrophy with autonomic disease 11.2
21 spinocerebellar ataxia 34 11.1
22 spastic paraplegia 2, x-linked 11.1
23 parkinsonism-dystonia, infantile, 2 11.1
24 deeah syndrome 11.1
25 bladder dysfunction, autonomic, with impaired pupillary reflex and secondary cakut 11.0
26 neuropathy, hereditary sensory and autonomic, type ia 11.0
27 paroxysmal extreme pain disorder 11.0
28 perry syndrome 11.0
29 neuropathy, hereditary sensory and autonomic, type iia 11.0
30 indifference to pain, congenital, autosomal recessive 11.0
31 parkinson disease 4, autosomal dominant 11.0
32 aromatic l-amino acid decarboxylase deficiency 11.0
33 sudden infant death with dysgenesis of the testes syndrome 11.0
34 neuropathy, hereditary sensory and autonomic, type ic 11.0
35 parkinson disease 5, autosomal dominant 11.0
36 brown-vialetto-van laere syndrome 11.0
37 striatonigral degeneration 11.0
38 brain dopamine-serotonin vesicular transport disease 11.0
39 opsoclonus-myoclonus syndrome 11.0
40 myoclonic encephalopathy of infants 11.0
41 autonomic neuropathy 10.8
42 orthostatic intolerance 10.6
43 neuropathy 10.6
44 syncope 10.6
45 guillain-barre syndrome 10.5
46 constipation 10.5
47 polyneuropathy 10.5
48 multiple sclerosis 10.5
49 resting heart rate, variation in 10.5
50 impotence 10.4

Graphical network of the top 20 diseases related to Autonomic Dysfunction:

Diseases related to Autonomic Dysfunction

Symptoms & Phenotypes for Autonomic Dysfunction

UMLS symptoms related to Autonomic Dysfunction:

seizures; tremor; constipation; vomiting; back pain; headache; syncope; diarrhea; mydriasis; pain; chronic pain; sciatica; anal pain; vertigo/dizziness; sleeplessness; rectal tenesmus; increased sweating; decrease in appetite; vomiting alone; rectal pain; dry throat; hyperemesis; vomiting in newborn; lightheadedness; warm skin; palpitations - fluttering; pounding heart; syncope, effort; blackout - symptom

MGI Mouse Phenotypes related to Autonomic Dysfunction:

# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.76 CHRNA3 DBH ECE1 PHOX2B RETREG1 SCN9A
2 normal MP:0002873 9.43 CPT2 DBH ECE1 PHOX2B SCN9A SNCA
3 vision/eye MP:0005391 9.1 CHRNA3 DBH ECE1 GMPPA PHOX2B USH2A

Drugs & Therapeutics for Autonomic Dysfunction

Drugs for Autonomic Dysfunction (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
Levodopa Approved Phase 4 59-92-7 6047
3 Neurotransmitter Agents Phase 4
4 Dopamine Agents Phase 4
5 Antiparkinson Agents Phase 4
6 Analgesics, Non-Narcotic Phase 2
7 Salicylsalicylic acid Phase 2
8 Sodium salicylate Phase 2 54-21-7
9 Antirheumatic Agents Phase 2
10 Analgesics Phase 2
11 Anti-Inflammatory Agents Phase 2
12 Anti-Inflammatory Agents, Non-Steroidal Phase 2
tannic acid Approved 1401-55-4
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
Norepinephrine Approved 51-41-2 439260
Nicotine Approved 54-11-5 942 89594
Alprazolam Approved, Illicit, Investigational Early Phase 1 28981-97-7 2118
Hydrocortisone Approved, Vet_approved 50-23-7 5754
Hydrocortisone acetate Approved, Vet_approved 50-03-3
Carvedilol Approved, Investigational 72956-09-3 2585
Palmitic Acid Approved 57-10-3 985
Glycerol Approved, Investigational 56-81-5 753
Epinephrine Approved, Vet_approved Early Phase 1 51-43-4 5816
Racepinephrine Approved Early Phase 1 329-65-7 838
Glucagon Approved Early Phase 1 16941-32-5
Angiotensin II Approved, Investigational Early Phase 1 68521-88-0, 11128-99-7, 4474-91-3 172198
27 Anesthetics
28 Tea
29 insulin Early Phase 1
30 Psychotropic Drugs Early Phase 1
31 Hypnotics and Sedatives Early Phase 1
32 GABA Modulators Early Phase 1
33 Hypoglycemic Agents Early Phase 1
34 Anti-Anxiety Agents Early Phase 1
35 Insulin, Globin Zinc Early Phase 1
36 Hydrocortisone hemisuccinate
37 Hydrocortisone 17-butyrate 21-propionate
38 Atomoxetine Hydrochloride Early Phase 1
39 Adrenergic alpha-Antagonists
40 Adrenergic alpha-1 Receptor Antagonists
41 Pharmaceutical Solutions
42 Adrenergic Antagonists
43 Soybean oil, phospholipid emulsion
44 Fat Emulsions, Intravenous
45 Adrenergic beta-Antagonists
46 Parenteral Nutrition Solutions
47 Soy Bean
48 Antioxidants
49 calcium channel blockers
50 Protective Agents

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 The Study of Heart Rate Variability in Patients With Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
2 Effect of Duodenal Levodopa Infusion on Quality of Life and Autonomic Dysfunction in Patients With Parkinson's Disease Completed NCT00914134 Phase 4 Levodopa infusion
3 Ivabradine in the Management of Cardiac Autonomic Dysfunction Associated With Thoracic Radiation Therapy. Recruiting NCT03137537 Phase 2 Ivabradine;Placebo Oral Tablet
4 Inflammation Inhibition for Microvascular and Autonomic Dysfunction in Obese Prediabetic Humans Terminated NCT01977417 Phase 2 Salsalate;Placebo
5 Effect of Physical Training in Patients With Heart Failure Caused by Chemotherapy for Cancer Treatment Unknown status NCT04047901
6 Is Acupoints Sensation Necessary for Acu-TENS to Elicit Physiological Changes in Healthy Subjects? Unknown status NCT01804192
7 Cognitive-Behavioral Therapy for Sleep Disturbance in Patients Undergoing Hemodialysis and Its Impacts on Their Inflammatory Cytokines, Oxidative Stress and Autonomic Dysfunction Unknown status NCT01159197
8 Evaluation of Sleep Disordered Breathing and Autonomic Dysfunction in Fibromyalgia Through Peripheral Arterial Tonometry Unknown status NCT01151163
9 Autonomic Dysfunction in Patients With Pectus Excavatum. Unknown status NCT03346876
10 ME/CFS: Activity Patterns and Autonomic Dysfunction Unknown status NCT02948556
11 The Role of Noradrenergic Network, and Its Association With Autonomous Dysfunction,Cerebral Autoregulation and microRNA in Parkinson Disease Before and After Medication and Rehabilitation Treatment Unknown status NCT02672943
12 Cardiac Sympathetic Innervation and Coronary Blood Flow Regulation During General Anesthesia Completed NCT00866801
13 The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction in Diabetic Patients Undergoing Retinal Surgery Completed NCT00919347
14 Autonom Dysrefleksi Ved Rygmarvsskade Completed NCT01059370
15 PD2i Analysis of Heart Rate Variability in Competitive Sports Completed NCT01249248
16 Autonomic Dysfunction and Inflammation in Chronic Hemodialysis Patients Completed NCT00878033
17 Implementation of a Transdiagnostic Psychological Group Intervention for Pediatric Autonomic Dysfunction Completed NCT03185247
18 Evaluation of the Compensatory Reserve Index and Psychosocial Factors in Pediatric Autonomic Dysfunction Completed NCT03974737
19 The Identification and Characterization of Autonomic Dysfunction in Migraineurs With and Without Auras Completed NCT01080287
20 Perioperative Heart Rate Variability Analysis in Realtime: Detection of Cardiovascular and Autonomic Dysfunction Completed NCT02761031
21 Inflammation, Autonomic Dysfunction and Airway Disease Completed NCT00005298
22 Preclinical Cardiomyopathy in Type 1 Diabetes: Correlation With Autonomic Dysfunction Completed NCT03930004
23 Mechanisms of Hypoglycemia-Associated Autonomic Dysfunction. The Effect of Alprazolam on Exercise Induced Hypoglycemia. Completed NCT00574639 Early Phase 1 Alprazolam;Placebo
24 Cardiac Autonomic Dysfunction is Predictive of Vasodepressor and Mixed Vaso Vagal Syncope Recurrence in a Propensity Score Matched Analysis of Type 2 Diabetics vs. Non Diabetics Patients Without Organic Heart Disease. Completed NCT03717207
25 Neurocardiogenic Syncope and the Role That Yoga Plays in People With Autonomic Dysfunction Completed NCT01695525 Early Phase 1
26 Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Question 3 Completed NCT00742521
27 Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q4-Atomoxetine Completed NCT00780650 Early Phase 1 Atomoxetine;Placebo
28 Free Fatty Acids-Induced Hypertension, Endothelial Dysfunction, Inflammation, Insulin Resistance, and Autonomic Dysfunction in Lean and Obese Subjects (Aim #2) Completed NCT02406586 Salsalate;Carvedilol;Placebo;Intralipid 20%
29 The Impact of Autonomic Dysfunction on Liver-Related Symptoms in Non-Alcoholic Fatty Liver Disease and Their Relationship to Systemic Inflammation and Insulin Resistance Completed NCT02132780
30 Free Fatty Acids-Induced Hypertension, Endothelial Dysfunction, Inflammation, Insulin Resistance, and Autonomic Dysfunction in Lean and Obese Subjects Completed NCT00721617
31 Pathogenesis and Diagnosis of Multiple System Atrophy (MSA): PET Study of Neurochemical and Autonomic Disorders in MSA Completed NCT02035761
32 Clinical Autonomic Disorders: A Training Protocol Completed NCT02154009
33 Cognitive Behavioral Treatment for Patients With Chronic Post-Concussion Symptoms Recruiting NCT03759808
34 Epidural Stimulation for Spinal Cord Injury Recruiting NCT03026816
35 Autonomic Cardiovascular Control in Response to Blood Volume Reduction in Blood Donors Recruiting NCT04499664
36 Effects of Heart Rate Variability Biofeedback to Improve Automatic Nervous Function, Inflammatory Response, Physiological and Psychological Symptom Distress in Patients With Chronic Kidney Disease:A Randomized Control Trial Recruiting NCT04611334
37 Impact of Sleep-disordered Breathing on Autonomic Regulation in Patients With Prader-Willi Syndrome Recruiting NCT04118816
38 Hypoglycemia Associated Autonomic Dysfunction Dose Response of Epinephrine Recruiting NCT02692313 Early Phase 1 Epinephrine
39 Implantable Cardiac Monitors in High-risk Post-infarction Patients With Cardiac Autonomic Dysfunction and Moderately Reduced Left Ventricular Ejection Fraction Recruiting NCT02594488
40 Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Differing Levels of Hypoglycemia Recruiting NCT02445781 Early Phase 1
41 Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome Active, not recruiting NCT02196376
42 Multifactorial Risk Stratification in Patients With Ischemic Stroke or Transient Ischemic Attack and Structural, Inflammatory, or Arrhythmogenic Cardiac Disease Active, not recruiting NCT04352790
43 Hypoglycemia Associated Autonomic Dysfunction Active, not recruiting NCT01858896 Early Phase 1 Glucagon-Like Peptide- 1 (GLP-1) infusion
44 Exercise and Its Cardiovascular Effects in Patients of Parkinson's Disease With Cardiovascular Autonomic Dysfunction Active, not recruiting NCT03343574
45 A Pilot Study to Quantify the Autonomic Nervous System Balance in Healthy, Able-Bodied Individuals Enrolling by invitation NCT04100486
46 Autonomic Dysfunction, Brain Blood Flow and Cognitive Decline in Veterans With Gulf War Illness Not yet recruiting NCT04586049
47 Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure Terminated NCT02591173 Early Phase 1 Angiotensin-(1-7);Saline
48 Evaluation of Autonomic Function in Individuals With Cornelia de Lange Syndrome (CdLS), a Pilot Study. Terminated NCT03113877
49 Autonomic Dysfunction and Spinal Cord Stimulator in Complex Regional Pain Syndrome Terminated NCT00780390

Search NIH Clinical Center for Autonomic Dysfunction

Genetic Tests for Autonomic Dysfunction

Anatomical Context for Autonomic Dysfunction

MalaCards organs/tissues related to Autonomic Dysfunction:

Heart, Spinal Cord, Liver, Eye, Endothelial, Cortex, Hypothalamus

Publications for Autonomic Dysfunction

Articles related to Autonomic Dysfunction:

(show top 50) (show all 6245)
# Title Authors PMID Year
Cardiac arrhythmias associated with volume-assured pressure support mode in a patient with autonomic dysfunction and mitochondrial disease. 61
33231166 2021
TS-HDS and FGFR3 Antibodies in Small Fiber Neuropathy and Dysautonomia. 61
33792960 2021
Investigating ELOVL7 coding variants in multiple system atrophy. 61
33600908 2021
Fluoxetine for the Symptomatic Treatment of Multiple System Atrophy: The MSA-FLUO Trial. 61
33792958 2021
Premutations in the FMR1 gene in Serbian patients with undetermined tremor, ataxia and parkinsonism. 61
33403926 2021
Interictal autonomic dysfunction. 61
33664205 2021
Restless legs syndrome is increased in postural orthostatic tachycardia syndrome. 61
33231164 2021
Systematic assessment of autonomic symptoms in restless legs syndrome. 61
33548567 2021
Audit of Gastrointestinal Manifestations in Patients with Loeys-Dietz Syndrome and Vascular Ehlers-Danlos Syndrome. 61
32306189 2021
Cardiovascular and sudomotor dysfunction in Hirayama disease. 61
31833036 2021
Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives. 61
33807256 2021
Neuropathy associated with IgA monoclonal Gammopathy. A harbinger of AL amyloidosis. 61
33578240 2021
Use of anticonvulsants and antidepressants for treatment of complex regional pain syndrome: a literature review. 61
33183126 2021
Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease. 61
33771108 2021
Air Pollution and Cardiac Arrhythmias: A Comprehensive Review. 61
32839041 2021
Cardiovascular autonomic nervous system dysfunction in chronic kidney disease and end-stage kidney disease: disruption of the complementary forces. 61
33395034 2021
Effect of COVID-19 home confinement in people with multiple sclerosis: sleep and cardiac autonomic function monitorization. 61
33753090 2021
Cardiac autonomic function in patients with early multiple sclerosis. 61
33665745 2021
Hereditary transthyretin amyloidosis in mainland China: a unicentric retrospective study. 61
33739616 2021
Sandhoff disease in the elderly: a case study. 61
33650927 2021
Can dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome? 61
33763793 2021
Aerobic or resistance training improves autonomic control of circulation in oophorectomized rats with cardiometabolic dysfunctions: Impact on renal oxidative stress. 61
33340684 2021
Caspr2 autoantibody-associated Morvan syndrome predating thymoma relapse by 30 months. 61
33485137 2021
Restoring Perivascular Adipose Tissue Function in Obesity Using Exercise. 61
33687595 2021
The Relationship between the Most Common Subtypes of Dementia and Orthostatic Hypotension in Older Adults. 61
33735870 2021
Cardiovascular autonomic dysfunction after stroke. 61
33687612 2021
Prevention and Management of Supine Hypertension in Patients With Orthostatic Hypotension. 61
31524637 2021
Beat-to-beat blood pressure variability in patients with obstructive sleep apnea. 61
33089774 2021
Physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease: a cross-sectional analysis. 61
33662597 2021
Inverted circadian variation of arterial pressure in a geriatric patient: an indicator of autonomic dysfunction. 61
33648443 2021
Cardiac Autonomic Dysfunction in Rheumatoid Arthritis: Importance of Comorbidities and Medications. 61
30048389 2021
Triple A (Allgrove) syndrome due to AAAS gene mutation with a rare association of amyotrophy. 61
32700293 2021
Autonomic Dysfunction and Neurohormonal Disorders in Atrial Fibrillation. 61
33516396 2021
Reduced Myocardial Uptake of 123I-MIBG in Congenital Insensitivity to Pain With Anhidrosis. 61
33351513 2021
Spinal cord infarction in a young patient with methamphetamine abuse. 61
33785605 2021
Therapeutic Applications of Botulinum Neurotoxin for Autonomic Symptoms in Parkinson's Disease: An Updated Review. 61
33808714 2021
Murine Esophagus Expresses Glial-Derived Central Nervous System Antigens. 61
33810144 2021
Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson's Disease? 61
33809767 2021
Association of fall risk factors and non-motor symptoms in patients with early Parkinson's disease. 61
33664423 2021
Systemic and cerebral circulatory adjustment within the first 60 s after active standing: An integrative physiological view. 61
33385733 2021
Assessment of myocardial sympathetic innervation with 18F-FDOPA-PET/CT in patients with autonomic dysfunction: Feasibility study in IPD patients. 61
33751475 2021
The impact of dysmenorrhea on pulmonary functions. 61
33723102 2021
Negative association between lipoprotein associated phospholipase A2 activity and baroreflex sensitivity in subjects with high normal blood pressure and a positive family history of hypertension. 61
33676381 2021
Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome. 61
33794313 2021
Association of heart rate variability with REM sleep without atonia in idiopathic REM sleep behavior disorder. 61
33112228 2021
Body composition during the first 4 months in infants affected by neonatal abstinence syndrome: a pilot study. 61
33650484 2021
The acute effect of dopamine infusion on lipid and cytokine concentrations in persons with a cervical spinal cord injury-a pilot study. 61
33564118 2021
Characterization of the changes in supine blood pressure with long-term use of droxidopa in patients with neurogenic orthostatic hypotension. 61
33521332 2021
MRI and pathology correlations in the medulla in sudden unexpected death in epilepsy (SUDEP): a postmortem study. 61
32559314 2021
Association of cardiac autonomic dysfunction with higher levels of plasma lipid metabolites in recent-onset type 2 diabetes. 61
33084971 2021

Variations for Autonomic Dysfunction

ClinVar genetic disease variations for Autonomic Dysfunction:

# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CPT2 NM_000098.3(CPT2):c.149C>A (p.Pro50His) SNV Pathogenic 8954 rs28936375 GRCh37: 1:53662764-53662764
GRCh38: 1:53197092-53197092
2 USH2A NM_007123.5(USH2A):c.2299del (p.Glu767fs) Deletion Pathogenic 2351 rs80338903 GRCh37: 1:216420437-216420437
GRCh38: 1:216247095-216247095
3 MYH8 , MYHAS NM_002472.3(MYH8):c.5743A>G (p.Ile1915Val) SNV Uncertain significance 598988 rs1216879928 GRCh37: 17:10293842-10293842
GRCh38: 17:10390525-10390525
4 USH2A-AS2 , USH2A NM_206933.3(USH2A):c.5003G>T (p.Gly1668Val) SNV Uncertain significance 598989 rs1265349835 GRCh37: 1:216258204-216258204
GRCh38: 1:216084862-216084862

Expression for Autonomic Dysfunction

Search GEO for disease gene expression data for Autonomic Dysfunction.

Pathways for Autonomic Dysfunction

Pathways related to Autonomic Dysfunction according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.33 SNCA SCN9A DBH

GO Terms for Autonomic Dysfunction

Cellular components related to Autonomic Dysfunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 8.62 USH2A SNCA

Biological processes related to Autonomic Dysfunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.33 SNCA DBH CHRNA3
2 excitatory postsynaptic potential GO:0060079 9.32 SNCA CHRNA3
3 sensory perception of pain GO:0019233 9.26 SCN9A RETREG1
4 positive regulation of receptor recycling GO:0001921 8.96 SNCA ECE1
5 positive regulation of cold-induced thermogenesis GO:0120162 8.8 PHOX2B DBH CPT2

Molecular functions related to Autonomic Dysfunction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 SNCA DBH

Sources for Autonomic Dysfunction

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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