MCID: ATN002
MIFTS: 52

Autonomic Nervous System Disease

Categories: Blood diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autonomic Nervous System Disease

MalaCards integrated aliases for Autonomic Nervous System Disease:

Name: Autonomic Nervous System Disease 12 15 17
Autonomic Nervous System Disorders 43 72
Abnormality of the Autonomic Nervous System 29
Autonomic Nervous System Dysfunction 6
Autonomic Nervous System Disorder 12
Autonomic Nervous System Diseases 75

Classifications:



External Ids:

Disease Ontology 12 DOID:11465
ICD9CM 35 337.1
UMLS 72 C0154691 C1145628

Summaries for Autonomic Nervous System Disease

MedlinePlus : 43 Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including Blood pressure problems Heart problems Trouble with breathing and swallowing Erectile dysfunction in men Autonomic nervous system disorders can occur alone or as the result of another disease, such as Parkinson's disease, alcoholism and diabetes. Problems can affect either part of the system, as in complex regional pain syndromes, or all of the system. Some types are temporary, but many worsen over time. When they affect your breathing or heart function, these disorders can be life-threatening. Some autonomic nervous system disorders get better when an underlying disease is treated. Often, however, there is no cure. In that case, the goal of treatment is to improve symptoms. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Autonomic Nervous System Disease, also known as autonomic nervous system disorders, is related to algoneurodystrophy and burning mouth syndrome, and has symptoms including seizures, tremor and constipation. An important gene associated with Autonomic Nervous System Disease is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Peptide ligand-binding receptors and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Acetylcarnitine and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord, and related phenotypes are behavior/neurological and renal/urinary system

Wikipedia : 75 Dysautonomia or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does... more...

Related Diseases for Autonomic Nervous System Disease

Diseases in the Autonomic Nervous System Disease family:

Rare Autonomic Nervous System Disorder

Diseases related to Autonomic Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
# Related Disease Score Top Affiliating Genes
1 algoneurodystrophy 30.7 NGF CALCA
2 burning mouth syndrome 30.4 TAC1 NGF
3 migraine with or without aura 1 30.2 TAC1 NPS CALCA
4 nervous system disease 30.1 TTR NGF INS ALB
5 complex regional pain syndrome 29.9 TAC1 NPY CALCA
6 constipation 29.8 TAC1 NPY CALCA
7 reflex sympathetic dystrophy 29.5 NPY NPS CHSY1 CALCA
8 peripheral nervous system disease 29.5 TTR TAC1 PHOX2B NGF INS ALB
9 autonomic neuropathy 29.4 NPY NGF INS ALB
10 hypertension, essential 28.7 NPY INS ALB ADRA2B
11 rare autonomic nervous system disorder 12.5
12 rare genetic autonomic nervous system disorder 12.5
13 autonomic dysfunction 11.9
14 autonomic peripheral neuropathy 11.5
15 multiple system atrophy 1 11.3
16 achalasia-addisonianism-alacrima syndrome 11.3
17 central hypoventilation syndrome, congenital 11.2
18 somatostatinoma 10.7 INS CALCA
19 noma 10.6 INS ALB
20 vasomotor rhinitis 10.6 TAC1 CALCA
21 severe nonproliferative diabetic retinopathy 10.5 INS ALB
22 neuroschistosomiasis 10.5 TAC1 NGF
23 paramyloidosis 10.5 TTR ALB
24 amyloid tumor 10.5 TTR CALCA
25 prurigo nodularis 10.5 TAC1 NGF
26 retinitis pigmentosa 68 10.5 TAC1 NPS
27 prolactin producing pituitary tumor 10.5 NGF CALCA
28 epicondylitis 10.5 TAC1 NPS
29 bladder neck obstruction 10.5 TTR TAC1
30 thyroid sarcoma 10.5 HBA1 CALCA
31 decubitus ulcer 10.4 TTR ALB
32 drug allergy 10.4 INS ALB
33 kwashiorkor 10.4 TTR ALB
34 plethora of newborn 10.4 INS CALCA
35 marasmus 10.4 TTR ALB
36 aleutian mink disease 10.4 TTR ALB
37 neurogenic arthropathy 10.4 NGF HBA1
38 carpal tunnel syndrome 10.4 TTR TAC1 INS
39 pancreatic somatostatinoma 10.4 PPY CALCA
40 chronic ulcer of skin 10.4 TTR ALB
41 neurodermatitis 10.4 TAC1 NPS INS
42 endocrine organ benign neoplasm 10.4 NGF INS CALCA
43 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.4 HBA2 HBA1
44 hyperthyroxinemia 10.3 TTR ALB
45 methemoglobinemia, beta-globin type 10.3 HBA2 HBA1
46 diabetes mellitus, insulin-dependent, 24 10.3 HBA2 HBA1
47 thyroid crisis 10.3 TTR ALB
48 hydrops fetalis, nonimmune 10.3 HBA2 HBA1
49 hydrops fetalis 10.3 HBA2 HBA1
50 glutathione peroxidase deficiency 10.3 HBA2 HBA1

Comorbidity relations with Autonomic Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Hypothyroidism
Parkinson Disease, Late-Onset Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Autonomic Nervous System Disease:



Diseases related to Autonomic Nervous System Disease

Symptoms & Phenotypes for Autonomic Nervous System Disease

UMLS symptoms related to Autonomic Nervous System Disease:


seizures, tremor, constipation, vomiting, back pain, pain, headache, diarrhea, syncope, mydriasis, chronic pain, sciatica, vertigo/dizziness, sleeplessness, rectal tenesmus, increased sweating, decrease in appetite, vomiting alone, rectal pain, dry throat, hyperemesis, anal pain, vomiting in newborn, lightheadedness, warm skin, palpitations - fluttering, pounding heart, syncope, effort, blackout - symptom

MGI Mouse Phenotypes related to Autonomic Nervous System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 ADRA2B CHSY1 DRD4 INS NGF NPY
2 renal/urinary system MP:0005367 9.1 ADRA2B ALB INS NPY TAC1 TTR

Drugs & Therapeutics for Autonomic Nervous System Disease

Drugs for Autonomic Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 7045767
2
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3 Micronutrients Phase 4
4 Nutrients Phase 4
5 Trace Elements Phase 4
6 Nootropic Agents Phase 4
7 Alpha-lipoic Acid Phase 4
8 carnitine Phase 4
9 Vitamins Phase 4
10 Vitamin B9 Phase 4
11 Folate Phase 4
12 Vitamin B Complex Phase 4
13 Thioctic Acid Phase 4
14
Ipratropium Approved, Experimental Phase 3 60205-81-4, 22254-24-6 657309 43232
15
Curcumin Approved, Experimental, Investigational Phase 3 458-37-7 969516
16
Levodopa Approved Phase 3 59-92-7 6047
17
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
18
Methyldopa Approved Phase 3 555-30-6 38853
19
Droxidopa Approved, Investigational Phase 3 23651-95-8 443940
20
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
21 Analgesics Phase 3
22 Cardiotonic Agents Phase 3
23 Cholinergic Antagonists Phase 3
24 Albuterol Phase 3
25 Pharmaceutical Solutions Phase 3
26 Anti-Inflammatory Agents Phase 3
27 Analgesics, Non-Narcotic Phase 3
28 Anti-Inflammatory Agents, Non-Steroidal Phase 3
29 Antirheumatic Agents Phase 3
30 Tocolytic Agents Phase 3
31 Adrenergic beta-2 Receptor Agonists Phase 3
32 Anticonvulsants Phase 3
33 Bromides Phase 3
34 Omega 3 Fatty Acid Phase 3
35 Adrenergic alpha-2 Receptor Agonists Phase 3
36 Gastrointestinal Agents Phase 3
37 alpha-methyltyrosine Phase 3
38 Antiemetics Phase 3
39 Neurotransmitter Uptake Inhibitors Phase 3
40 Sympatholytics Phase 3
41 Atomoxetine Hydrochloride Phase 3
42 Dopamine Antagonists Phase 3
43 Dopamine D2 Receptor Antagonists Phase 3
44 Antiparkinson Agents Phase 3
45
Iron Approved, Experimental Phase 2 15438-31-0, 7439-89-6 23925 27284
46
Liraglutide Approved Phase 2 204656-20-2 44147092
47
Dopamine Approved Phase 1, Phase 2 51-61-6, 62-31-7 681
48
Norepinephrine Approved Phase 1, Phase 2 51-41-2 439260
49
Carbidopa Approved Phase 1, Phase 2 28860-95-9 34359
50
Baclofen Approved Phase 2 1134-47-0 2284

Interventional clinical trials:

(show top 50) (show all 106)
# Name Status NCT ID Phase Drugs
1 Sympathetic Heart Innervation in Patients With Previous Experience of Transient Stress-induced Cardiomyopathy (Tako-Tsubo): Effects of α-lipoic Acid and L-acetyl Carnitine Therapies. Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
2 The Effects of Bronchodilator Therapy On Respiratory and Autonomic Function in Patients With Familial Dysautonomia Completed NCT01987219 Phase 3 Albuterol-sulphate;Ipratropium-bromide
3 A Multi-center, Open-label Study to Assess the Long-term Safety of Droxidopa in Subjects With Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency or Non-Diabetic Neuropathy and Symptomatic Neurogenic Orthostatic Hypotension Completed NCT01132326 Phase 3 Droxidopa
4 Neural Consequences of Chronic Inflammation in Individuals With Spinal Cord Injury and the Influence of an Anti-inflammatory Diet Completed NCT02099890 Phase 3
5 Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia Completed NCT01212484 Phase 3 Carbidopa;Placebo
6 An Open-label Study, to Assess the Long-term Safety and Clinical Benefit of Droxidopa in Subjects With PAF, Dopamine Beta Hydroxylase Deficiency or Non-diabetic Neuropathy and Symptomatic Neurogenic Orthostatic Hypotension Completed NCT00738062 Phase 3 Droxidopa;Placebo
7 Phase III, Multi-Center, Study to Assess the Clinical Effect of Droxidopa in Subjects With Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency or Non-Diabetic Neuropathy and Symptomatic NOH Completed NCT00633880 Phase 3 Placebo;Droxidopa
8 Phase III, Multi-Center, Study to Assess the Clinical Effect of Droxidopa in Subjects With Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency or Non-Diabetic Neuropathy and Symptomatic NOH Completed NCT00782340 Phase 3 Placebo;Droxidopa
9 Treatment of Hypotensive Patients Having a Unique Pattern of Autonomic Symptoms Enrolling by invitation NCT00581477 Phase 3 droxidopa;placebo;alpha-methyldopa;carbidopa;metyrosine;levodopa;atomoxetine;metoclopramide
10 A Clinical Study of Patients With Symptomatic Neurogenic Orthostatic Hypotension to Assess Sustained Effects of Droxidopa Therapy Terminated NCT01927055 Phase 3 Droxidopa;Placebo
11 A Study Evaluating Hypotension and Autonomic Nervous System Dysfunction During Spinal Anesthesia for Cesarean Section and Its Relation to the Effect of Prophylaxis Phenylephrine Completed NCT02958215 Phase 2 Phenylephrine
12 Efficacy of Ferric Carboxymaltose in Gastrointestinal Stromal Tumor (GIST) Patients With Iron Deficiency Anemia (IDA) Receiving Systemic Therapy Completed NCT02949947 Phase 2 Ferric Carboxymaltose
13 The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes Recruiting NCT03426085 Phase 2 Liraglutide 6 mg Solution for Injection
14 Ivabradine in the Management of Cardiac Autonomic Dysfunction Associated With Thoracic Radiation Therapy. Recruiting NCT03137537 Phase 2 Ivabradine;Placebo Oral Tablet
15 Carbidopa in Familial Dysautonomia: Phase-II Study, Investigational New Drug (IND) 117435, Date: 01/07/13 Recruiting NCT02553265 Phase 2 Carbidopa Low Dose;Carbidopa High Dose
16 The Nutritional Supplement Phosphatidylserine in Patients With Familial Recruiting NCT02276716 Phase 2 Phosphatidylserine
17 Early Treatment of Paroxysmal Dysautonomia and Hypertonia for Severe Brain Injured Patients by Intrathecal Baclofen Therapy Terminated NCT00221689 Phase 2 baclofen (drug)
18 L-Dihydroxyphenylserine (L-DOPS) for Norepinephrine Deficiency: Interactions With Carbidopa and Entacapone Terminated NCT00547911 Phase 1, Phase 2 Droxidopa;Carbidopa;Entacapone
19 The Safety , Tolerability and Efficacy of Dronabinol, a Synthetic Endocannabinoid Receptor Agonist, for the Treatment of Nausea and Vomiting in Patients With Familial Dysautonomia Withdrawn NCT02608931 Phase 2 Dronabinol
20 Controlling Hyperadrenergic Activity in Neurologic Injury Withdrawn NCT01343329 Phase 1, Phase 2 Esmolol;Propranolol
21 The Safety and Tolerability of Kinetin, a Nutritional Supplement That Corrects the Splicing Defect, in Patients With Familial Dysautonomia Completed NCT02274051 Phase 1
22 Effects of Biofeedback Combined With Abdominal Breathing on Physiological and Psychological Aspects in Patients With Acute Cerebral Infarction Completed NCT03516227 Phase 1
23 The Pathophysiology of Orthostatic Hypotension Active, not recruiting NCT00748059 Phase 1 phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine;clonidine,yohimbine,metoclopramide,alpha-methyldopa
24 Is Acupoints Sensation Necessary for Acu-TENS to Elicit Physiological Changes in Healthy Subjects? Unknown status NCT01804192
25 Autonomic Dysfunction in Patients With Pectus Excavatum. Unknown status NCT03346876
26 A Pilot Study Evaluating Hypotension and Autonomic Nervous System Dysfunction After Therapy With Bortezomib-containing Regimens in Subjects With Multiple Myeloma Unknown status NCT01314625
27 Autonomic Cardiovascular Neuropathy in Recently Diagnosed DM2 Patients and in Pre-Diabetes Patients Unknown status NCT02931773
28 Noninvasive Study of the Time Course of Baroreflex Sensitivity 6-Month After Acute Ischemic Stroke and the Relation of Its Changes With Post Stroke Prognosis Unknown status NCT00422474
29 A Multicenter Longitudinal Observational Study Evaluating Genotypic Association wIth Clinical Outcomes in Interventional Pain Management Modalities Unknown status NCT02485795
30 Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Arterial Stiffness and Blood Pressure in Resistant Hypertensive Individuals Unknown status NCT02365974
31 Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Hemodynamics and Vascular Function Unknown status NCT03225898
32 Pain Modulation in RA - Influence of Adalimumab. A Randomized, Placebo-controlled Study Using Functional Magnetic Resonance Imaging (PARADE) Unknown status NCT01197144 adalimumab;Placebo
33 Variations of Heart Rate Variability and Skin Conductance Reveal the Influence of CV4 and Rib Raising Osteopathic Techniques on the Autonomic Nervous System: a Randomized Controlled Trial Completed NCT03142373
34 Blood Sampling for Neurochemical and Genetic Testing Completed NCT00001147
35 The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction in Diabetic Patients Undergoing Retinal Surgery Completed NCT00919347
36 Plasma Catecholamine Kinetics Completed NCT00001329
37 Autonomic Dysfunction and Inflammation in Chronic Hemodialysis Patients Completed NCT00878033
38 Autonomic Responses During the Valsalva Maneuver and Deep Breathing Test Depend on the Experimental Setup Completed NCT02397681
39 PD2i Analysis of Heart Rate Variability in Competitive Sports Completed NCT01249248
40 Effect of Exercise Training in Autonomic Modulation in Breast Cancer Patients Treated With Doxorubicin Completed NCT02584712
41 Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia Completed NCT02913651
42 Effect of Salbutamol on Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease Completed NCT04062409
43 Phase 1 Study - Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System improVement in Patients After MI With or Without hypErtension After Cardiovascular Rehabilitation. Completed NCT02195388
44 Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children Completed NCT02830022
45 Autonomic Effects of T4 Mobilization in Asymptomatic Subjects: Randomized Clinical Trial Completed NCT02164123
46 The Identification and Characterization of Autonomic Dysfunction in Migraineurs With and Without Auras Completed NCT01080287
47 Autonom Dysrefleksi Ved Rygmarvsskade Completed NCT01059370
48 Autonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study Completed NCT00466778
49 Preoperative Evaluation of Autonomic Nervous System by Heart Rate Variability as a Predictor of Postoperative Outcome in the Patient Undergoing Major Elective Abdominal Surgery Completed NCT02375412
50 Positron Emission Tomographic (PET) Scanning of Sympathetic Innervation and Function in Patients With Neurocardiologic Disorders Completed NCT00001418

Search NIH Clinical Center for Autonomic Nervous System Disease

Genetic Tests for Autonomic Nervous System Disease

Genetic tests related to Autonomic Nervous System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Autonomic Nervous System 29

Anatomical Context for Autonomic Nervous System Disease

MalaCards organs/tissues related to Autonomic Nervous System Disease:

41
Heart, Testes, Spinal Cord, Brain, Liver, Endothelial, Skin

Publications for Autonomic Nervous System Disease

Articles related to Autonomic Nervous System Disease:

(show top 50) (show all 81)
# Title Authors PMID Year
1
Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. 71
7881421 1994
2
Complex regional pain syndrome: a narrative review for the practising clinician. 17
31056241 2019
3
Recommendations in Post-exercise Hypotension: Concerns, Best Practices and Interpretation. 17
31288287 2019
4
Thalamic and cerebellar hypoperfusion in single photon emission computed tomography may differentiate multiple system atrophy and progressive supranuclear palsy. 17
31348305 2019
5
Effects of inspiratory muscle training on respiratory muscle strength, lung function, functional capacity and cardiac autonomic function in Parkinson's disease: Randomized controlled clinical trial protocol. 38
31090181 2019
6
Pelvic Electric Potential as a Marker of Autonomic Dysfunctions and Risk Factor of Neurogenic Arrhythmias in Humans. 38
30627894 2019
7
Evaluation of postural tachycardia syndrome (POTS). 38
29705015 2018
8
[Analysis of the extension of childhood expectations and evaluation of the risks of the development of diseases associated with overweight]. 38
29783222 2018
9
Targets and Therapeutics for Glycemic Control in Diabetes Patients on Hemodialysis. 38
30041202 2018
10
Neurological and neuropsychological complications in the course of chronic Whipple's disease - case report. 38
29289973 2017
11
Antiarrhythmic properties of atrial pacing. 38
28791857 2017
12
Some Non-FDA Approved Uses for Neuromodulation in Treating Autonomic Nervous System Disorders: A Discussion of the Preliminary Support. 38
27339825 2016
13
Seborrheic dermatitis treatment with stellate ganglion block: a case report. 38
27064785 2016
14
Endoscopic Findings of Small-Bowel Lesions in Familial Amyloid Polyneuropathy: A Case Report. 38
26986100 2016
15
[Current pharmacotherapy of the autonomic nervous system disorders]. 38
26977913 2015
16
[The Four-Dimensional Symptom Questionnaire (4DSQ) to assess distress, depression, anxiety and somatization in autonomic and borderline psychosomatic disorders]. 38
25591639 2014
17
[The primary screening of patients with autonomic disorders in outpatient clinics in Russia (START1) using the Russian version of The Four-Dimensional Symptom Questionnaire (4DSQ)]. 38
25726790 2014
18
[Sanatorium care in autonomic nervous system disorders]. 38
25176267 2014
19
Characteristic features of migraine in schoolchildren and adolescents and its relationship with autonomic nervous system disorders. 38
23771848 2013
20
Alterations in TH- and ChAT-immunoreactive neurons in the DMV and gastric dysmotility in an LPS-induced PD rat model. 38
23701914 2013
21
[Characteristics of the autonomic nervous system state in children with myopia associated with undifferentiated connective tissue dysplasia]. 38
24340615 2013
22
Syndromes of orthostatic intolerance: a hidden danger. 38
23216860 2013
23
[Vagotonía. The medical thesis of Salvador Zubirán]. 38
23227589 2012
24
Co-morbidities of interstitial cystitis. 38
22907988 2012
25
The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease. 38
23110271 2012
26
Obesity-related autonomic nervous system disorders are best associated with body fat mass index, a new indicator. 38
21963211 2011
27
A novel pharmacological approach to determining parasympathetic heart rate reserve in human subjects. 38
20861836 2010
28
European teaching course on autonomic nervous system disorders : reaching out to young physicians. 38
19350223 2009
29
Central nervous system plus autonomic nervous system disorders responsible for gastrointestinal and pancreatobiliary diseases. 38
18629642 2009
30
Evaluation and management of autonomic nervous system disorders. 38
18351521 2008
31
Autonomic function in tension-type headache. 38
18416283 2007
32
[Botulinum toxin type A and cholinergic system]. 38
18383744 2007
33
[Diagnosis and treatment of Madelung's disease]. 38
17007380 2006
34
Skin sympathetic adrenergic innervation: an immunofluorescence confocal study. 38
16437571 2006
35
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. 38
16412483 2006
36
[Clinical analysis of autonomic nervous system disorders in patients with psoriasis concurrent with chronic opisthorchiasis]. 38
16562741 2006
37
[Neuroretinitis, Parry-Romberg syndrome, and scleroderma]. 38
16249769 2005
38
May fever trigger ventricular fibrillation? 38
16943953 2005
39
[Therapy for patients with mental and autonomic nervous system disorders in Parkinson's disease]. 38
13677892 2003
40
Age-related differences in the side effect profile of citalopram. 38
12691792 2003
41
Comprehensive study of autonomic function in a population with primary Sjögren's syndrome. No evidence of autonomic involvement. 38
12508393 2003
42
[Clinical course of autonomic nervous system disorders in veterans with consequences of combat mild brain injury]. 38
12616732 2003
43
Other noncosmetic uses of BOTOX. 38
12195265 2002
44
Other noncosmetic uses of BOTOX. 38
11474744 2001
45
[Acupuncture correction of autonomic nervous system disorders in patients with bronchial asthma]. 38
11490414 2001
46
The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial. 38
10599797 1999
47
Autonomic nervous system disorders in stroke. 38
10638806 1999
48
Evaluation of the cardiac autonomic nervous system in spontaneously non-insulin-dependent diabetic rats by 123I-metaiodobenzylguanidine imaging. 38
10202944 1999
49
[Segmental autonomic nervous system disorders in patients with vibration disease due to local vibration]. 38
10097572 1999
50
Amisulpride in medium-term treatment of dysthymia: a six-month, double-blind safety study versus amitriptyline. AMILONG investigators. 38
10512080 1999

Variations for Autonomic Nervous System Disease

ClinVar genetic disease variations for Autonomic Nervous System Disease:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 DRD4 NM_000797.4(DRD4): c.235_247del (p.Ala79fs) deletion Pathogenic rs587776842 11:637539-637551 11:637539-637551

Expression for Autonomic Nervous System Disease

Search GEO for disease gene expression data for Autonomic Nervous System Disease.

GO Terms for Autonomic Nervous System Disease

Cellular components related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 TTR TAC1 PPY NPY NGF INS
2 blood microparticle GO:0072562 9.54 HBA2 HBA1 ALB
3 extracellular region GO:0005576 9.4 TTR TAC1 PPY NPY NPS NGF
4 endocytic vesicle lumen GO:0071682 9.32 HBA2 HBA1
5 hemoglobin complex GO:0005833 9.26 HBA2 HBA1
6 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA2 HBA1

Biological processes related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.73 TAC1 INS CALCA ADRA2B
2 cellular protein metabolic process GO:0044267 9.71 TTR INS CALCA ALB
3 positive regulation of neuron differentiation GO:0045666 9.65 PHOX2B NGF ADRA2B
4 cellular oxidant detoxification GO:0098869 9.63 HBA2 HBA1 ALB
5 hydrogen peroxide catabolic process GO:0042744 9.58 HBA2 HBA1
6 positive regulation of blood vessel diameter GO:0097755 9.58 INS CALCA
7 dopaminergic neuron differentiation GO:0071542 9.57 PHOX2B PHOX2A
8 G protein-coupled receptor signaling pathway GO:0007186 9.56 TAC1 PPY NPY NPS INS DRD4
9 negative regulation of protein secretion GO:0050709 9.54 INS DRD4
10 regulation of blood pressure GO:0008217 9.54 TAC1 NPY CALCA
11 sympathetic nervous system development GO:0048485 9.52 PHOX2B PHOX2A
12 oxygen transport GO:0015671 9.51 HBA2 HBA1
13 positive regulation of synaptic transmission, GABAergic GO:0032230 9.49 TAC1 NPS
14 positive regulation of action potential GO:0045760 9.32 TAC1 NPS
15 negative regulation of ossification GO:0030279 9.26 CHSY1
16 noradrenergic neuron differentiation GO:0003357 9.26 PHOX2B PHOX2A
17 response to pain GO:0048265 9.25 TAC1
18 parasympathetic nervous system development GO:0048486 9.16 PHOX2B PHOX2A
19 neuropeptide signaling pathway GO:0007218 8.92 TAC1 PPY NPY NPS

Molecular functions related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.58 NPY NGF CALCA
2 neuropeptide hormone activity GO:0005184 9.43 PPY NPY
3 oxygen carrier activity GO:0005344 9.37 HBA2 HBA1
4 organic acid binding GO:0043177 9.32 HBA2 HBA1
5 haptoglobin binding GO:0031720 9.26 HBA2 HBA1
6 epinephrine binding GO:0051379 9.16 DRD4 ADRA2B
7 oxygen binding GO:0019825 9.13 HBA2 HBA1 ALB
8 hormone activity GO:0005179 9.02 TTR PPY NPY INS CALCA

Sources for Autonomic Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....