MCID: ATN002
MIFTS: 54

Autonomic Nervous System Disease

Categories: Blood diseases, Neuronal diseases

Aliases & Classifications for Autonomic Nervous System Disease

MalaCards integrated aliases for Autonomic Nervous System Disease:

Name: Autonomic Nervous System Disease 12 15 17
Autonomic Nervous System Disorders 44 74
Abnormality of the Autonomic Nervous System 30
Autonomic Nervous System Dysfunction 6
Autonomic Nervous System Disorder 12
Autonomic Nervous System Diseases 77

Classifications:



External Ids:

Disease Ontology 12 DOID:11465
ICD9CM 36 337.1
ICD10 34 G90 G90.8 G99.1

Summaries for Autonomic Nervous System Disease

MedlinePlus : 44 Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including Blood pressure problems Heart problems Trouble with breathing and swallowing Erectile dysfunction in men Autonomic nervous system disorders can occur alone or as the result of another disease, such as Parkinson's disease, alcoholism and diabetes. Problems can affect either part of the system, as in complex regional pain syndromes, or all of the system. Some types are temporary, but many worsen over time. When they affect your breathing or heart function, these disorders can be life-threatening. Some autonomic nervous system disorders get better when an underlying disease is treated. Often, however, there is no cure. In that case, the goal of treatment is to improve symptoms. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Autonomic Nervous System Disease, also known as autonomic nervous system disorders, is related to algoneurodystrophy and burning mouth syndrome, and has symptoms including seizures, tremor and constipation. An important gene associated with Autonomic Nervous System Disease is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Peptide ligand-binding receptors and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Dopamine and Rotigotine have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and brain, and related phenotypes are behavior/neurological and renal/urinary system

Wikipedia : 77 Dysautonomia or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does... more...

Related Diseases for Autonomic Nervous System Disease

Diseases related to Autonomic Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 115)
# Related Disease Score Top Affiliating Genes
1 algoneurodystrophy 30.4 CALCA NGF
2 burning mouth syndrome 30.2 NGF TAC1
3 reflex sympathetic dystrophy 29.7 CALCA CHSY1 NPS NPY
4 autonomic peripheral neuropathy 11.4
5 multiple system atrophy 1 11.2
6 central hypoventilation syndrome, congenital 11.1
7 somatostatinoma 10.4 CALCA INS
8 burn scar 10.4 CALCA TAC1
9 noma 10.4 ALB INS
10 vasomotor rhinitis 10.4 CALCA TAC1
11 neuroschistosomiasis 10.3 NGF TAC1
12 severe nonproliferative diabetic retinopathy 10.3 ALB INS
13 retinitis pigmentosa 68 10.3 NPS TAC1
14 prurigo nodularis 10.3 NGF TAC1
15 paramyloidosis 10.3 ALB TTR
16 epicondylitis 10.3 NPS TAC1
17 prolactin producing pituitary tumor 10.3 CALCA NGF
18 amyloid tumor 10.3 CALCA TTR
19 thyroid sarcoma 10.3 CALCA HBA1
20 bladder neck obstruction 10.3 TAC1 TTR
21 drug allergy 10.3 ALB INS
22 marasmus 10.3 ALB TTR
23 kwashiorkor 10.3 ALB TTR
24 decubitus ulcer 10.3 ALB TTR
25 plethora of newborn 10.2 CALCA INS
26 neurogenic arthropathy 10.2 HBA1 NGF
27 pancreatic somatostatinoma 10.2 CALCA PPY
28 aleutian mink disease 10.2 ALB TTR
29 carpal tunnel syndrome 10.2 INS TAC1 TTR
30 neurodermatitis 10.2 INS NPS TAC1
31 endocrine organ benign neoplasm 10.2 CALCA INS NGF
32 chronic ulcer of skin 10.2 ALB TTR
33 alpha-thalassemia/mental retardation syndrome, chromosome 16-related 10.2 HBA1 HBA2
34 microvascular complications of diabetes 3 10.2 ALB INS
35 thyroid crisis 10.2 ALB TTR
36 methemoglobinemia, beta-globin type 10.2 HBA1 HBA2
37 diabetes mellitus, insulin-dependent, 24 10.2 HBA1 HBA2
38 hydrops fetalis, nonimmune 10.2 HBA1 HBA2
39 hydrops fetalis 10.2 HBA1 HBA2
40 hyperthyroxinemia 10.2 ALB TTR
41 burns 10.2 ALB INS TTR
42 glutathione peroxidase deficiency 10.2 HBA1 HBA2
43 leprosy 2 10.2 CALCA NPY
44 migraine with or without aura 1 10.2 CALCA NPS TAC1
45 heinz body anemias 10.2 HBA1 HBA2
46 exotropia 10.2 PHOX2A PHOX2B
47 erythrocytosis, familial, 7 10.2 HBA1 HBA2
48 dental pulp disease 10.2 NPS TAC1
49 immature cataract 10.2 HBA1 HBA2
50 pancreatic cholera 10.2 CALCA PPY

Comorbidity relations with Autonomic Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Parkinson Disease, Late-Onset
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Autonomic Nervous System Disease:



Diseases related to Autonomic Nervous System Disease

Symptoms & Phenotypes for Autonomic Nervous System Disease

UMLS symptoms related to Autonomic Nervous System Disease:


seizures, tremor, constipation, vomiting, back pain, pain, diarrhea, headache, syncope, mydriasis, chronic pain, sciatica, vertigo/dizziness, sleeplessness, rectal tenesmus, increased sweating, decrease in appetite, vomiting alone, rectal pain, dry throat, hyperemesis, anal pain, vomiting in newborn, lightheadedness, warm skin, palpitations - fluttering, pounding heart, syncope, effort, blackout - symptom

MGI Mouse Phenotypes related to Autonomic Nervous System Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 ADRA2B CHSY1 DRD4 INS NGF NPY
2 renal/urinary system MP:0005367 9.1 ADRA2B ALB INS NPY TAC1 TTR

Drugs & Therapeutics for Autonomic Nervous System Disease

Drugs for Autonomic Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 512)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 62-31-7, 51-61-6 681
2
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Diphenhydramine Approved, Investigational Phase 4,Phase 1 147-24-0, 58-73-1 3100
5
Zolpidem Approved Phase 4,Not Applicable 82626-48-0 5732
6
Promethazine Approved, Investigational Phase 4,Phase 1 60-87-7 4927
7
Midodrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 133163-28-7, 42794-76-3 4195
8
Acetylcholine Approved, Investigational Phase 4,Not Applicable,Early Phase 1 51-84-3 187
9
Lidocaine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 137-58-6 3676
10
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
11
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
12
Droxidopa Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 23651-95-8 443940
13
Norepinephrine Approved Phase 4,Phase 2,Phase 1,Not Applicable 51-41-2 439260
14
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
15
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-92-7 6047
16
Propranolol Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 525-66-6 4946
17
tannic acid Approved Phase 4,Phase 2,Phase 3,Not Applicable 1401-55-4
18
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
19
Acetylcarnitine Approved, Investigational Phase 4,Phase 3 3040-38-8 7045767
20
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
21
Bisoprolol Approved Phase 4 66722-44-9 2405
22
Fludrocortisone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 127-31-1 31378
23
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
24
Furosemide Approved, Vet_approved Phase 4,Not Applicable 54-31-9 3440
25
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
26
Atorvastatin Approved Phase 4 134523-00-5 60823
27
Indapamide Approved Phase 4 26807-65-8 3702
28
Pseudoephedrine Approved Phase 4,Phase 1,Not Applicable,Early Phase 1 90-82-4 7028
29
Oxymetazoline Approved, Investigational Phase 4,Phase 1,Not Applicable,Early Phase 1 1491-59-4 4636
30
Ephedrine Approved Phase 4,Phase 1,Not Applicable,Early Phase 1 299-42-3 9294
31
Phenylephrine Approved Phase 4,Phase 1,Not Applicable,Early Phase 1 59-42-7 6041
32
Tamsulosin Approved, Investigational Phase 4,Phase 1,Not Applicable 106133-20-4 129211
33
Metronidazole Approved Phase 4 443-48-1 4173
34
Naloxone Approved, Vet_approved Phase 4,Phase 2 465-65-6 5284596
35
Diazoxide Approved Phase 4 364-98-7 3019
36
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-81-7 5785 54670067
37
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
38
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable 7440-70-2 271
39
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 1406-16-2
40
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
41 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Dopamine agonists Phase 4,Phase 1,Not Applicable
43 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Serotonin Agents Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Serotonin Antagonists Phase 4
46 GABA Agonists Phase 4
47 GABA-A Receptor Agonists Phase 4
48 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
49 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Antipsychotic Agents Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 594)
# Name Status NCT ID Phase Drugs
1 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Unknown status NCT03098368 Phase 4 Rotigotine;Placebo
2 Risperidone and Zotepine in the Treatment of Delirium Unknown status NCT00622011 Phase 4 Risperidone and Zolpidem for delirium
3 Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study) Unknown status NCT01621464 Phase 4
4 Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV Unknown status NCT01456481 Phase 4 midodrine hydrochloride;matching placebo
5 Botulinum A Toxin in Patients With Parkinson's Disease Unknown status NCT00822913 Phase 4 Intravesical injection of Botulinum A toxin
6 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4 BOTOX
7 Duodenal Levodopa Infusion, Quality of Life and Autonomic Nervous System in Parkinson's Disease Completed NCT00914134 Phase 4 Levodopa infusion
8 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
9 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
10 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Completed NCT01823770 Phase 4 Rotigotine;Placebo patchs
11 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
12 Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
13 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
14 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4 Propranolol
15 Effects of DPP4 Inhibitor Versus SGLT2 Inhibitor Completed NCT03178591 Phase 4 vildagliptin;Dapagliflozin
16 Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study Completed NCT02308124 Phase 4 Midodrine;Pyridostigmine Bromide;Midodrine + pyridostigmine
17 Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01518946 Phase 4 Midodrine HCl;Placebo
18 Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01515865 Phase 4 Midodrine HCl;Placebo
19 Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Completed NCT00555880 Phase 4 Midodrine hydrochloride;Placebo
20 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
21 Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS) Completed NCT02171988 Phase 4 Propranolol;Bisoprolol;Propranolol+pyridostigmine;Bisoprolol+pyridostgmine
22 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Completed NCT03291197 Phase 4 Suprascapular and median nerve blocks
23 Clinical Trial for the Prevention of Vasovagal Syncope Completed NCT00118482 Phase 4 fludrocortisone acetate
24 Restore Claims Characterization Study Completed NCT00200122 Phase 4
25 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
26 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
27 Renal Denervation in Diabetic Nephropathy Completed NCT01588795 Phase 4 Standardized antiproteinuric medication regimen includes an angiotensin receptor blocker , a diuretic , 25OH vitamin D3 and a statin
28 Effectiveness of Saccharomyces Boulardii for Gastrointestinal Bacterial-overgrowth in Systemic Sclerosis Recruiting NCT03692299 Phase 4 Saccharomyces Boulardii Oral Tablet;Metronidazole
29 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
30 Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH Recruiting NCT03350659 Phase 4 Midodrine;Atomoxetine
31 Dawn Simulation and Postural Hypotension Recruiting NCT02632318 Phase 4
32 Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF) Recruiting NCT03608163 Phase 4 Naloxone;Diazoxide;Placebo (for Naloxone);Placebo (for Diazoxide)
33 Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury Recruiting NCT03602014 Phase 4 Northera
34 Brain Perfusion & Oxygenation in Parkinson's Disease With NOH Recruiting NCT03229174 Phase 4 Droxidopa;Placebo
35 Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Recruiting NCT02123056 Phase 4 Metoprolol;Matching Placebo
36 Exploration of Pupil Dilation in Horner's Patients Taking Flomax Recruiting NCT03615508 Phase 4 10% phenylephrine
37 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4 midodrine hydrochloride (ProAmatine®)
38 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
39 Clinical Trial on the Effectiveness of Traditional Chinese Medicinal Mixture in Parkinson Disease Unknown status NCT00629161 Phase 2, Phase 3 Traditional Chinese Medicinal Mixture (composed of Roucongrong and adjuvant);placebo
40 Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA Unknown status NCT02071459 Phase 2, Phase 3 L-Threo DOPS;placebo
41 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
42 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
43 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
44 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
45 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
46 The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia Completed NCT01987219 Phase 3 Albuterol-sulphate;Ipratropium-bromide
47 Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia Completed NCT01212484 Phase 3 Carbidopa;Placebo
48 Clinical Trial to Measure the Maximun HR After ReConnect ® Supplementation vs. Placebo in CFS. Completed NCT02063126 Phase 2, Phase 3
49 Clinical Study on Acetyl-L-Carnitine Completed NCT01526564 Phase 3 Acetylcarnitine;Placebo
50 Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis Completed NCT00409175 Phase 2, Phase 3 Fx-1006A;Placebo

Search NIH Clinical Center for Autonomic Nervous System Disease

Genetic Tests for Autonomic Nervous System Disease

Genetic tests related to Autonomic Nervous System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Autonomic Nervous System 30

Anatomical Context for Autonomic Nervous System Disease

MalaCards organs/tissues related to Autonomic Nervous System Disease:

42
Heart, Spinal Cord, Brain, Testes, Liver, Bone, Cortex

Publications for Autonomic Nervous System Disease

Articles related to Autonomic Nervous System Disease:

(show all 14)
# Title Authors Year
1
Some Non-FDA Approved Uses for Neuromodulation in Treating Autonomic Nervous System Disorders: A Discussion of the Preliminary Support. ( 27339825 )
2016
2
Characteristic features of migraine in schoolchildren and adolescents and its relationship with autonomic nervous system disorders. ( 23771848 )
2013
3
The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease. ( 23110271 )
2012
4
Obesity-related autonomic nervous system disorders are best associated with body fat mass index, a new indicator. ( 21963211 )
2011
5
Central nervous system plus autonomic nervous system disorders responsible for gastrointestinal and pancreatobiliary diseases. ( 18629642 )
2009
6
European teaching course on autonomic nervous system disorders : reaching out to young physicians. ( 19350223 )
2009
7
Evaluation and management of autonomic nervous system disorders. ( 18351521 )
2008
8
Autonomic nervous system disorders in stroke. ( 10638806 )
1999
9
Autonomic nervous system disorders and erectile dysfunction. ( 8876372 )
1996
10
Autonomic nervous system disorders and reflex sympathetic dystrophy in lightning and electrical injuries. ( 8848658 )
1995
11
Adrenocorticotropic hormone insensitivity associated with autonomic nervous system disorders. ( 1655458 )
1991
12
Autonomic nervous system disorders in Parkinson's disease. ( 1855522 )
1991
13
Selective ACTH insensitivity associated with autonomic nervous system disorders and sensory polyneuropathy. ( 2828065 )
1987
14
[Treatment of autonomic nervous system disorders; a contribution from neurological practice]. ( 13122652 )
1953

Variations for Autonomic Nervous System Disease

ClinVar genetic disease variations for Autonomic Nervous System Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DRD4 NM_000797.3(DRD4): c.235_247delGCCGACCTCCTCC (p.Ala79Serfs) deletion Pathogenic rs587776842 GRCh38 Chromosome 11, 637539: 637551
2 DRD4 NM_000797.3(DRD4): c.235_247delGCCGACCTCCTCC (p.Ala79Serfs) deletion Pathogenic rs587776842 GRCh37 Chromosome 11, 637539: 637551

Expression for Autonomic Nervous System Disease

Search GEO for disease gene expression data for Autonomic Nervous System Disease.

GO Terms for Autonomic Nervous System Disease

Cellular components related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 ALB CALCA HBA1 HBA2 INS NGF
2 blood microparticle GO:0072562 9.54 ALB HBA1 HBA2
3 extracellular region GO:0005576 9.4 ALB CALCA CHSY1 HBA1 HBA2 INS
4 endocytic vesicle lumen GO:0071682 9.32 HBA1 HBA2
5 hemoglobin complex GO:0005833 9.26 HBA1 HBA2
6 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA1 HBA2

Biological processes related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.76 ADRA2B CALCA INS TAC1
2 cellular protein metabolic process GO:0044267 9.73 ALB CALCA INS TTR
3 positive regulation of neuron differentiation GO:0045666 9.67 ADRA2B NGF PHOX2B
4 cellular oxidant detoxification GO:0098869 9.65 ALB HBA1 HBA2
5 regulation of signaling receptor activity GO:0010469 9.63 CALCA INS NGF NPY PPY TTR
6 hydrogen peroxide catabolic process GO:0042744 9.59 HBA1 HBA2
7 positive regulation of blood vessel diameter GO:0097755 9.58 CALCA INS
8 dopaminergic neuron differentiation GO:0071542 9.58 PHOX2A PHOX2B
9 regulation of blood pressure GO:0008217 9.58 CALCA NPY TAC1
10 negative regulation of ossification GO:0030279 9.57 CALCA CHSY1
11 response to pain GO:0048265 9.56 CALCA TAC1
12 G protein-coupled receptor signaling pathway GO:0007186 9.56 ADRA2B CALCA DRD4 INS NPS NPY
13 negative regulation of protein secretion GO:0050709 9.55 DRD4 INS
14 oxygen transport GO:0015671 9.54 HBA1 HBA2
15 sympathetic nervous system development GO:0048485 9.52 PHOX2A PHOX2B
16 positive regulation of synaptic transmission, GABAergic GO:0032230 9.51 NPS TAC1
17 noradrenergic neuron differentiation GO:0003357 9.37 PHOX2A PHOX2B
18 positive regulation of action potential GO:0045760 9.32 NPS TAC1
19 parasympathetic nervous system development GO:0048486 9.26 PHOX2A PHOX2B
20 neuropeptide signaling pathway GO:0007218 9.02 CALCA NPS NPY PPY TAC1

Molecular functions related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.58 CALCA NGF NPY
2 neuropeptide hormone activity GO:0005184 9.43 NPY PPY
3 oxygen carrier activity GO:0005344 9.37 HBA1 HBA2
4 organic acid binding GO:0043177 9.32 HBA1 HBA2
5 haptoglobin binding GO:0031720 9.26 HBA1 HBA2
6 epinephrine binding GO:0051379 9.16 ADRA2B DRD4
7 oxygen binding GO:0019825 9.13 ALB HBA1 HBA2
8 hormone activity GO:0005179 9.02 CALCA INS NPY PPY TTR

Sources for Autonomic Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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