MCID: ATN002
MIFTS: 49

Autonomic Nervous System Disease

Categories: Blood diseases, Neuronal diseases

Aliases & Classifications for Autonomic Nervous System Disease

MalaCards integrated aliases for Autonomic Nervous System Disease:

Name: Autonomic Nervous System Disease 12 15
Autonomic Nervous System Disorders 43 73
Abnormality of the Autonomic Nervous System 29
Autonomic Nervous System Dysfunction 6
Autonomic Nervous System Disorder 12
Autonomic Nervous System Diseases 76

Classifications:



External Ids:

Disease Ontology 12 DOID:11465
ICD9CM 35 337.1
ICD10 33 G90 G90.8 G99.1

Summaries for Autonomic Nervous System Disease

MedlinePlus : 43 Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including Blood pressure problems Heart problems Trouble with breathing and swallowing Erectile dysfunction in men Autonomic nervous system disorders can occur alone or as the result of another disease, such as Parkinson's disease, alcoholism and diabetes. Problems can affect either part of the system, as in complex regional pain syndromes, or all of the system. Some types are temporary, but many worsen over time. When they affect your breathing or heart function, these disorders can be life-threatening. Some autonomic nervous system disorders get better when an underlying disease is treated. Often, however, there is no cure. In that case, the goal of treatment is to improve symptoms. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Autonomic Nervous System Disease, also known as autonomic nervous system disorders, is related to central hypoventilation syndrome, congenital and algoneurodystrophy, and has symptoms including seizures, tremor and constipation. An important gene associated with Autonomic Nervous System Disease is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Risperidone and Zolpidem have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and testes, and related phenotypes are behavior/neurological and normal

Wikipedia : 76 Dysautonomia or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does... more...

Related Diseases for Autonomic Nervous System Disease

Diseases related to Autonomic Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 central hypoventilation syndrome, congenital 31.3 ASCL1 EDNRB PHOX2A PHOX2B
2 algoneurodystrophy 30.0 CALCA NGF
3 burning mouth syndrome 30.0 NGF TAC1
4 reflex sympathetic dystrophy 29.7 CALCA CHSY1 NPS NPY
5 asthma 29.6 CALCA INS NGF NPY TAC1
6 autonomic peripheral neuropathy 11.3
7 multiple system atrophy 1 11.2
8 burns 10.2 INS TTR
9 duodenal somatostatinoma 10.2 CALCA INS
10 somatostatinoma 10.2 CALCA INS
11 burn scar 10.2 CALCA TAC1
12 vasomotor rhinitis 10.2 CALCA TAC1
13 bladder neck obstruction 10.2 TAC1 TTR
14 retinitis pigmentosa 68 10.2 NPS TAC1
15 epicondylitis 10.2 NPS TAC1
16 severe nonproliferative diabetic retinopathy 10.2 ALB INS
17 noma 10.2 ALB INS
18 paramyloidosis 10.2 ALB TTR
19 amyloid tumor 10.2 CALCA TTR
20 bullous impetigo 10.2 CALCA EDNRB
21 impetigo 10.2 CALCA EDNRB
22 neuroschistosomiasis 10.2 NGF TAC1
23 drug allergy 10.2 ALB INS
24 prurigo nodularis 10.2 NGF TAC1
25 plethora of newborn 10.2 CALCA INS
26 carpal tunnel syndrome 10.1 INS TAC1 TTR
27 marasmus 10.1 ALB TTR
28 kwashiorkor 10.1 ALB TTR
29 decubitus ulcer 10.1 ALB TTR
30 stereotypic movement disorder 10.1 NPY TAC1
31 leprosy 2 10.1 CALCA NPY
32 aleutian mink disease 10.1 ALB TTR
33 neurodermatitis 10.1 INS NPS TAC1
34 chronic ulcer of skin 10.1 ALB TTR
35 hypoglycemic coma 10.1 HBA2 INS
36 microvascular complications of diabetes 3 10.1 ALB INS
37 thyroid crisis 10.1 ALB TTR
38 hyperthyroxinemia 10.1 ALB TTR
39 type 1 diabetes mellitus 7 10.1 HBA2 INS
40 prolactin producing pituitary tumor 10.1 CALCA NGF
41 dental pulp disease 10.1 NPS TAC1
42 epispadias 10.1 CALCA NPY
43 type 1 diabetes mellitus 11 10.1 HBA2 INS
44 multiple endocrine neoplasia, type iib 10.1 CALCA EDNRB
45 aspiration pneumonia 10.1 ALB TAC1
46 fetal erythroblastosis 10.1 ALB INS
47 blind loop syndrome 10.1 ALB TTR
48 endocrine organ benign neoplasm 10.0 CALCA INS NGF
49 complex regional pain syndrome 10.0 CALCA NPY TAC1
50 indeterminate leprosy 10.0 NPS NPY TAC1

Comorbidity relations with Autonomic Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Parkinson Disease, Late-Onset
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Autonomic Nervous System Disease:



Diseases related to Autonomic Nervous System Disease

Symptoms & Phenotypes for Autonomic Nervous System Disease

UMLS symptoms related to Autonomic Nervous System Disease:


seizures, tremor, constipation, vomiting, back pain, pain, diarrhea, headache, syncope, mydriasis, chronic pain, sciatica, increased sweating, vertigo/dizziness, sleeplessness, rectal tenesmus, decrease in appetite, vomiting alone, rectal pain, dry throat, hyperemesis, anal pain, vomiting in newborn, lightheadedness, warm skin, palpitations - fluttering, pounding heart, syncope, effort, blackout - symptom

MGI Mouse Phenotypes related to Autonomic Nervous System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 ASCL1 CHSY1 DRD4 EDNRB INS NGF
2 normal MP:0002873 9.7 ALB ASCL1 INS NGF NPY PHOX2B
3 renal/urinary system MP:0005367 9.43 ALB EDNRB INS NPY TAC1 TTR
4 vision/eye MP:0005391 9.23 ASCL1 CHSY1 DRD4 EDNRB INS NGF

Drugs & Therapeutics for Autonomic Nervous System Disease

Drugs for Autonomic Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 515)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
2
Zolpidem Approved Phase 4,Not Applicable 82626-48-0 5732
3
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
4
Midodrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 133163-28-7, 42794-76-3 4195
5
Acetylcholine Approved Phase 4,Not Applicable,Early Phase 1 51-84-3 187
6
Lidocaine Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 137-58-6 3676
7
Norepinephrine Approved Phase 4,Phase 2,Phase 1,Not Applicable 51-41-2 439260
8
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
9
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
10
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
11
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-92-7 6047
12
Propranolol Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 525-66-6 4946
13 tannic acid Approved Phase 4,Phase 2,Phase 3,Not Applicable
14
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 94-09-7, 1994-09-7 2337
15
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
16
Acetylcarnitine Approved, Investigational Phase 4,Phase 3 3040-38-8 1
17
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
18
Bisoprolol Approved Phase 4 66722-44-9 2405
19
Fludrocortisone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 127-31-1 31378
20
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
21
gamma-Aminobutyric acid Approved, Investigational Phase 4,Not Applicable 56-12-2 119
22
Furosemide Approved, Vet_approved Phase 4,Not Applicable 54-31-9 3440
23
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
24
Indapamide Approved Phase 4 26807-65-8 3702
25
Droxidopa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23651-95-8 443940
26
Pseudoephedrine Approved Phase 4,Phase 1,Not Applicable,Early Phase 1 90-82-4 7028
27
Phenylephrine Approved Phase 4,Phase 1,Not Applicable,Early Phase 1 59-42-7 6041
28
Oxymetazoline Approved, Investigational Phase 4,Phase 1,Not Applicable,Early Phase 1 1491-59-4 4636
29
Tamsulosin Approved, Investigational Phase 4,Phase 1,Not Applicable 106133-20-4 129211
30
Ephedrine Approved Phase 4,Phase 1,Not Applicable,Early Phase 1 299-42-3 9294
31
Metronidazole Approved Phase 4 443-48-1 4173
32
Naloxone Approved, Vet_approved Phase 4,Phase 2 465-65-6 5284596
33
Diazoxide Approved Phase 4 364-98-7 3019
34
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-81-7 5785 54670067
35
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
36
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 1406-16-2
37
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
38 GABA-A Receptor Agonists Phase 4
39 GABA Agonists Phase 4
40 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
41 Dopamine Antagonists Phase 4,Phase 3,Phase 1
42 Antipsychotic Agents Phase 4,Phase 3,Not Applicable
43 Hypnotics and Sedatives Phase 4,Phase 1,Early Phase 1,Not Applicable
44 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Serotonin Antagonists Phase 4
46 Serotonin Agents Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
49 GABA Agents Phase 4,Early Phase 1,Not Applicable
50 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 578)
# Name Status NCT ID Phase Drugs
1 Risperidone and Zotepine in the Treatment of Delirium Unknown status NCT00622011 Phase 4 Risperidone and Zolpidem for delirium
2 Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study) Unknown status NCT01621464 Phase 4
3 Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV Unknown status NCT01456481 Phase 4 midodrine hydrochloride;matching placebo
4 Botulinum A Toxin in Patients With Parkinson's Disease Unknown status NCT00822913 Phase 4 Intravesical injection of Botulinum A toxin
5 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4 BOTOX
6 Duodenal Levodopa Infusion, Quality of Life and Autonomic Nervous System in Parkinson's Disease Completed NCT00914134 Phase 4 Levodopa infusion
7 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
8 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
9 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Completed NCT01823770 Phase 4 Rotigotine;Placebo patchs
10 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Completed NCT03226119 Phase 4
11 Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
12 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
13 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4 Propranolol
14 Effects of DPP4 Inhibitor Versus SGLT2 Inhibitor Completed NCT03178591 Phase 4 vildagliptin;Dapagliflozin
15 Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study Completed NCT02308124 Phase 4 Midodrine;Pyridostigmine Bromide;Midodrine + pyridostigmine
16 Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01518946 Phase 4 Midodrine HCl;Placebo
17 Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01515865 Phase 4 Midodrine HCl;Placebo
18 Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Completed NCT00555880 Phase 4 Midodrine hydrochloride;Placebo
19 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
20 Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS) Completed NCT02171988 Phase 4 Propranolol;Bisoprolol;Propranolol+pyridostigmine;Bisoprolol+pyridostgmine
21 Clinical Trial for the Prevention of Vasovagal Syncope Completed NCT00118482 Phase 4 fludrocortisone acetate
22 Restore Claims Characterization Study Completed NCT00200122 Phase 4
23 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
24 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
25 Renal Denervation in Diabetic Nephropathy Completed NCT01588795 Phase 4 Standardized antiproteinuric medication regimen includes an angiotensin receptor blocker , a diuretic , 25OH vitamin D3 and a statin
26 Effectiveness of Saccharomyces Boulardii for Gastrointestinal Bacterial-overgrowth in Systemic Sclerosis Recruiting NCT03692299 Phase 4 Saccharomyces Boulardii Oral Tablet;Metronidazole
27 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
28 Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH Recruiting NCT03350659 Phase 4 Midodrine;Atomoxetine
29 Dawn Simulation and Postural Hypotension Recruiting NCT02632318 Phase 4
30 Novel Approach for the Prevention of Hypoglycemia Associated Autonomic Failure (HAAF) Recruiting NCT03608163 Phase 4 Naloxone;Diazoxide;Placebo (for Naloxone);Placebo (for Diazoxide)
31 Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury Recruiting NCT03602014 Phase 4 Northera
32 Brain Perfusion & Oxygenation in Parkinson's Disease With NOH Recruiting NCT03229174 Phase 4 Droxidopa;Placebo
33 Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Recruiting NCT02123056 Phase 4 Metoprolol;Matching Placebo
34 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
35 Exploration of Pupil Dilation in Horner's Patients Taking Flomax Recruiting NCT03615508 Phase 4 10% phenylephrine
36 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Active, not recruiting NCT03098368 Phase 4 Rotigotine;Placebo
37 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4 midodrine hydrochloride (ProAmatine®)
38 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
39 Clinical Trial on the Effectiveness of Traditional Chinese Medicinal Mixture in Parkinson Disease Unknown status NCT00629161 Phase 2, Phase 3 Traditional Chinese Medicinal Mixture (composed of Roucongrong and adjuvant);placebo
40 Role of Vitamin C at 6 Months on Incidence of Complex Regional Pain Syndrome Type I in Upper Limb Surgery Unknown status NCT02390505 Phase 3 Vitamin C;Placebo
41 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
42 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
43 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
44 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
45 The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia Completed NCT01987219 Phase 3 Albuterol-sulphate;Ipratropium-bromide
46 Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia Completed NCT01212484 Phase 3 Carbidopa;Placebo
47 Clinical Trial to Measure the Maximun HR After ReConnect ® Supplementation vs. Placebo in CFS. Completed NCT02063126 Phase 2, Phase 3
48 Clinical Study on Acetyl-L-Carnitine Completed NCT01526564 Phase 3 Acetylcarnitine;Placebo
49 Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis Completed NCT00409175 Phase 2, Phase 3 Fx-1006A;Placebo
50 The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury Completed NCT02099890 Phase 3

Search NIH Clinical Center for Autonomic Nervous System Disease

Genetic Tests for Autonomic Nervous System Disease

Genetic tests related to Autonomic Nervous System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Autonomic Nervous System 29

Anatomical Context for Autonomic Nervous System Disease

MalaCards organs/tissues related to Autonomic Nervous System Disease:

41
Heart, Skin, Testes, Kidney, Pituitary, Thyroid

Publications for Autonomic Nervous System Disease

Articles related to Autonomic Nervous System Disease:

(show all 14)
# Title Authors Year
1
Some Non-FDA Approved Uses for Neuromodulation in Treating Autonomic Nervous System Disorders: A Discussion of the Preliminary Support. ( 27339825 )
2016
2
Characteristic features of migraine in schoolchildren and adolescents and its relationship with autonomic nervous system disorders. ( 23771848 )
2013
3
The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease. ( 23110271 )
2012
4
Obesity-related autonomic nervous system disorders are best associated with body fat mass index, a new indicator. ( 21963211 )
2011
5
Central nervous system plus autonomic nervous system disorders responsible for gastrointestinal and pancreatobiliary diseases. ( 18629642 )
2009
6
European teaching course on autonomic nervous system disorders : reaching out to young physicians. ( 19350223 )
2009
7
Evaluation and management of autonomic nervous system disorders. ( 18351521 )
2008
8
Autonomic nervous system disorders in stroke. ( 10638806 )
1999
9
Autonomic nervous system disorders and erectile dysfunction. ( 8876372 )
1996
10
Autonomic nervous system disorders and reflex sympathetic dystrophy in lightning and electrical injuries. ( 8848658 )
1995
11
Adrenocorticotropic hormone insensitivity associated with autonomic nervous system disorders. ( 1655458 )
1991
12
Autonomic nervous system disorders in Parkinson's disease. ( 1855522 )
1991
13
Selective ACTH insensitivity associated with autonomic nervous system disorders and sensory polyneuropathy. ( 2828065 )
1987
14
[Treatment of autonomic nervous system disorders; a contribution from neurological practice]. ( 13122652 )
1953

Variations for Autonomic Nervous System Disease

ClinVar genetic disease variations for Autonomic Nervous System Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DRD4 NM_000797.3(DRD4): c.235_247delGCCGACCTCCTCC (p.Ala79Serfs) deletion Pathogenic rs587776842 GRCh38 Chromosome 11, 637539: 637551
2 DRD4 NM_000797.3(DRD4): c.235_247delGCCGACCTCCTCC (p.Ala79Serfs) deletion Pathogenic rs587776842 GRCh37 Chromosome 11, 637539: 637551

Expression for Autonomic Nervous System Disease

Search GEO for disease gene expression data for Autonomic Nervous System Disease.

Pathways for Autonomic Nervous System Disease

Pathways related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 ALB ASCL1 INS
2 11.23 ASCL1 NGF PHOX2A PHOX2B TAC1
3 10.98 ALB INS TTR
4 10.66 CALCA EDNRB NPY

GO Terms for Autonomic Nervous System Disease

Cellular components related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ALB CALCA HBA2 INS NGF NPY
2 extracellular region GO:0005576 9.32 ALB CALCA CHSY1 HBA2 INS NGF

Biological processes related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.95 CALCA DRD4 EDNRB INS NPS NPY
2 regulation of signaling receptor activity GO:0010469 9.88 CALCA INS NGF NPY TTR
3 cellular protein metabolic process GO:0044267 9.8 ALB CALCA INS TTR
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.79 CALCA EDNRB TAC1
5 positive regulation of neuron differentiation GO:0045666 9.7 ASCL1 NGF PHOX2B
6 peripheral nervous system development GO:0007422 9.62 EDNRB NGF
7 positive regulation of blood vessel diameter GO:0097755 9.61 CALCA INS
8 dopaminergic neuron differentiation GO:0071542 9.61 PHOX2A PHOX2B
9 negative regulation of ossification GO:0030279 9.6 CALCA CHSY1
10 vasodilation GO:0042311 9.59 CALCA EDNRB
11 negative regulation of protein secretion GO:0050709 9.58 DRD4 INS
12 glial cell differentiation GO:0010001 9.58 ASCL1 PHOX2B
13 central nervous system neuron development GO:0021954 9.57 ASCL1 NPY
14 positive regulation of renal sodium excretion GO:0035815 9.56 EDNRB TAC1
15 neuropeptide signaling pathway GO:0007218 9.56 CALCA NPS NPY TAC1
16 enteric nervous system development GO:0048484 9.55 EDNRB PHOX2B
17 positive regulation of synaptic transmission, GABAergic GO:0032230 9.54 NPS TAC1
18 sympathetic ganglion development GO:0061549 9.51 ASCL1 PHOX2B
19 noradrenergic neuron differentiation GO:0003357 9.46 PHOX2A PHOX2B
20 positive regulation of action potential GO:0045760 9.43 NPS TAC1
21 noradrenergic neuron development GO:0003358 9.37 ASCL1 PHOX2B
22 response to pain GO:0048265 9.33 CALCA EDNRB TAC1
23 parasympathetic nervous system development GO:0048486 9.32 PHOX2A PHOX2B
24 sympathetic nervous system development GO:0048485 9.13 ASCL1 PHOX2A PHOX2B
25 regulation of blood pressure GO:0008217 8.92 CALCA EDNRB NPY TAC1

Molecular functions related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.26 CALCA NGF NPY TAC1
2 hormone activity GO:0005179 8.92 CALCA INS NPY TTR

Sources for Autonomic Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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