Autonomic Nervous System Disease

Categories: Blood diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Autonomic Nervous System Disease

MalaCards integrated aliases for Autonomic Nervous System Disease:

Name: Autonomic Nervous System Disease 12 15 17
Autonomic Nervous System Disorders 42 71
Abnormality of the Autonomic Nervous System 29
Autonomic Nervous System Dysfunction 6
Autonomic Nervous System Disorder 12
Autonomic Nervous System Diseases 74


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Disease Ontology 12 DOID:11465
ICD9CM 34 337.1
UMLS 71 C0154691 C1145628

Summaries for Autonomic Nervous System Disease

MedlinePlus : 42 Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including Blood pressure problems Heart problems Trouble with breathing and swallowing Erectile dysfunction in men Autonomic nervous system disorders can occur alone or as the result of another disease, such as Parkinson's disease, alcoholism and diabetes. Problems can affect either part of the system, as in complex regional pain syndromes, or all of the system. Some types are temporary, but many worsen over time. When they affect your breathing or heart function, these disorders can be life-threatening. Some autonomic nervous system disorders get better when an underlying disease is treated. Often, however, there is no cure. In that case, the goal of treatment is to improve symptoms. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Autonomic Nervous System Disease, also known as autonomic nervous system disorders, is related to central hypoventilation syndrome, congenital and pure autonomic failure, and has symptoms including seizures, tremor and constipation. An important gene associated with Autonomic Nervous System Disease is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Peptide ligand-binding receptors and Peptide hormone metabolism. The drugs Acetylcarnitine and Folic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 74 Dysautonomia or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does... more...

Related Diseases for Autonomic Nervous System Disease

Diseases in the Autonomic Nervous System Disease family:

Rare Autonomic Nervous System Disorder

Diseases related to Autonomic Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 central hypoventilation syndrome, congenital 32.5 TACR1 TAC1 PHOX2B
2 pure autonomic failure 30.8 TTR REN ACE
3 algoneurodystrophy 30.7 NGF INS CALCA
4 uremia 30.6 REN INS ALB ACE
5 sexual disorder 30.6 INS ALB ACE
6 central sleep apnea 30.6 REN PHOX2B ACE
7 congestive heart failure 30.5 REN NPY INS ALB ACE
8 fibromyalgia 30.5 TACR1 NPY NGF INS CALCA
9 burning mouth syndrome 30.5 TRPV1 TAC1 NGF CALCA
10 reflex sympathetic dystrophy 30.5 TAC1 NPY NPS CALCA
11 sleep disorder 30.4 REN NPS INS ACE
12 hydrocephalus 30.4 TTR NPY NGF ACE
13 apnea, obstructive sleep 30.3 REN PHOX2B INS GCG ALB ACE
14 mood disorder 30.3 TACR1 NPY DRD4 ACE
15 cerebrovascular disease 30.3 TTR REN INS ACE
16 pulmonary disease, chronic obstructive 30.3 TRPV1 TAC1 INS ALB ACE
17 complex regional pain syndrome 30.2 TACR1 TAC1 NPY CALCA ACE
18 sleep apnea 30.2 TAC1 REN PHOX2B NPS INS ALB
19 anxiety 30.2 TAC1 NPY NPS NGF INS DRD4
20 constipation 30.1 TACR1 TAC1 NPY GCG CALCA
21 polyneuropathy 30.1 TTR NGF INS CALCA ALB ACE
22 asthma 30.1 TRPV1 TACR1 TAC1 NPY NGF INS
23 kidney disease 30.0 TTR REN INS GCG ALB ACE
24 heart disease 29.8 TTR REN NPY MIR223 INS GCG
25 diabetes mellitus 29.8 REN NPY MIR223 INS GCG ALB
26 alzheimer disease 29.6 TTR NPY NGF INS GCG DRD4
27 autonomic neuropathy 29.6 TTR REN PPY NPY NGF INS
28 peripheral nervous system disease 29.4 TTR TRPV1 TAC1 PHOX2B NPS NGF
29 body mass index quantitative trait locus 11 29.3 TRPV1 REN NPY NPS MIR223 INS
30 migraine with or without aura 1 29.1 TRPV1 TACR1 TAC1 NPY NPS NGF
31 hypertension, essential 28.7 TTR TAC1 REN NPY NPS NGF
32 rare autonomic nervous system disorder 12.5
33 rare genetic autonomic nervous system disorder 12.5
34 autonomic dysfunction 11.9
35 autonomic peripheral neuropathy 11.5
36 multiple system atrophy 1 11.3
37 achalasia-addisonianism-alacrima syndrome 11.3
38 paroxysmal extreme pain disorder 11.2
39 benign pleural mesothelioma 10.6 TTR INS
40 transient refractive change 10.6 TAC1 INS
41 prurigo nodularis 10.6 TAC1 NGF
42 erythematosquamous dermatosis 10.6 INS GCG
43 neurotrophic keratopathy 10.6 TACR1 TAC1
44 carbamazepine allergy 10.6 TAC1 NPS CALCA
45 hirata disease 10.6 INS GCG
46 conjunctival deposit 10.6 TTR ACE
47 blind loop syndrome 10.6 TTR ALB
48 leprosy 2 10.6 NPY CALCA
49 mediastinitis 10.6 TTR INS ALB
50 marasmus 10.6 TTR INS ALB

Comorbidity relations with Autonomic Nervous System Disease via Phenotypic Disease Network (PDN):

Acute Cystitis Deficiency Anemia
Hypertension, Essential Hypothyroidism
Parkinson Disease, Late-Onset Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Autonomic Nervous System Disease:

Diseases related to Autonomic Nervous System Disease

Symptoms & Phenotypes for Autonomic Nervous System Disease

UMLS symptoms related to Autonomic Nervous System Disease:

seizures, tremor, constipation, vomiting, back pain, pain, headache, diarrhea, syncope, mydriasis, chronic pain, sciatica, vertigo/dizziness, sleeplessness, rectal tenesmus, increased sweating, decrease in appetite, vomiting alone, rectal pain, dry throat, hyperemesis, anal pain, vomiting in newborn, lightheadedness, warm skin, palpitations - fluttering, pounding heart, syncope, effort, blackout - symptom

MGI Mouse Phenotypes related to Autonomic Nervous System Disease:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 ACE DRD4 INS NGF NPY PHOX2B
2 cardiovascular system MP:0005385 9.7 ACE ADAM8 ALB INS NGF PHOX2B
3 renal/urinary system MP:0005367 9.23 ACE ALB INS NPY REN TAC1

Drugs & Therapeutics for Autonomic Nervous System Disease

Drugs for Autonomic Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 154)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 7045767
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
3 Trace Elements Phase 4
4 carnitine Phase 4
5 Micronutrients Phase 4
6 Vitamins Phase 4
7 Vitamin B Complex Phase 4
8 Nootropic Agents Phase 4
9 Nutrients Phase 4
10 Alpha-lipoic Acid Phase 4
11 Vitamin B9 Phase 4
12 Folate Phase 4
13 Thioctic Acid Phase 4
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
Droxidopa Approved, Investigational Phase 3 23651-95-8 443940
Carbidopa Approved Phase 3 28860-95-9 34359
Ipratropium Approved, Experimental Phase 3 22254-24-6, 60205-81-4 43232 657309
Curcumin Approved, Experimental, Investigational Phase 3 458-37-7 969516
Methyldopa Approved Phase 3 555-30-6 38853
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
Levodopa Approved Phase 3 59-92-7 6047
22 Dopamine Agents Phase 3
23 Antiparkinson Agents Phase 3
24 Aromatic Amino Acid Decarboxylase Inhibitors Phase 3
25 Sympathomimetics Phase 3
26 Analgesics Phase 3
27 Cholinergic Antagonists Phase 3
28 Albuterol Phase 3
29 Pharmaceutical Solutions Phase 3
30 Anti-Inflammatory Agents Phase 3
31 Analgesics, Non-Narcotic Phase 3
32 Anti-Inflammatory Agents, Non-Steroidal Phase 3
33 Antirheumatic Agents Phase 3
34 Tocolytic Agents Phase 3
35 Anticonvulsants Phase 3
36 Bromides Phase 3
37 Omega 3 Fatty Acid Phase 3
38 Antiemetics Phase 3
39 Gastrointestinal Agents Phase 3
40 Dopamine D2 Receptor Antagonists Phase 3
41 Adrenergic alpha-2 Receptor Agonists Phase 3
42 alpha-methyltyrosine Phase 3
43 Atomoxetine Hydrochloride Phase 3
44 Dopamine Antagonists Phase 3
45 Sympatholytics Phase 3
Liraglutide Approved Phase 2 204656-20-2 44147092
Norepinephrine Approved Phase 1, Phase 2 51-41-2 439260
Baclofen Approved Phase 2 1134-47-0 2284
Entacapone Approved, Investigational Phase 1, Phase 2 130929-57-6 5281081
50 Incretins Phase 2

Interventional clinical trials:

(show top 50) (show all 106)
# Name Status NCT ID Phase Drugs
1 Sympathetic Heart Innervation in Patients With Previous Experience of Transient Stress-induced Cardiomyopathy (Tako-Tsubo): Effects of α-lipoic Acid and L-acetyl Carnitine Therapies. Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
2 The Effects of Bronchodilator Therapy On Respiratory and Autonomic Function in Patients With Familial Dysautonomia Completed NCT01987219 Phase 3 Albuterol-sulphate;Ipratropium-bromide
3 A Multi-center, Open-label Study to Assess the Long-term Safety of Droxidopa in Subjects With Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency or Non-Diabetic Neuropathy and Symptomatic Neurogenic Orthostatic Hypotension Completed NCT01132326 Phase 3 Droxidopa
4 Neural Consequences of Chronic Inflammation in Individuals With Spinal Cord Injury and the Influence of an Anti-inflammatory Diet Completed NCT02099890 Phase 3
5 An Open-label Study, to Assess the Long-term Safety and Clinical Benefit of Droxidopa in Subjects With PAF, Dopamine Beta Hydroxylase Deficiency or Non-diabetic Neuropathy and Symptomatic Neurogenic Orthostatic Hypotension Completed NCT00738062 Phase 3 Droxidopa;Placebo
6 Phase III, Multi-Center, Study to Assess the Clinical Effect of Droxidopa in Subjects With Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency or Non-Diabetic Neuropathy and Symptomatic NOH Completed NCT00782340 Phase 3 Placebo;Droxidopa
7 Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia Completed NCT01212484 Phase 3 Carbidopa;Placebo
8 Phase III, Multi-Center, Study to Assess the Clinical Effect of Droxidopa in Subjects With Primary Autonomic Failure, Dopamine Beta Hydroxylase Deficiency or Non-Diabetic Neuropathy and Symptomatic NOH Completed NCT00633880 Phase 3 Placebo;Droxidopa
9 Treatment of Hypotensive Patients Having a Unique Pattern of Autonomic Symptoms Enrolling by invitation NCT00581477 Phase 3 droxidopa;placebo;alpha-methyldopa;carbidopa;metyrosine;levodopa;atomoxetine;metoclopramide
10 A Study Evaluating Hypotension and Autonomic Nervous System Dysfunction During Spinal Anesthesia for Cesarean Section and Its Relation to the Effect of Prophylaxis Phenylephrine Completed NCT02958215 Phase 2 Phenylephrine
11 Carbidopa in Familial Dysautonomia: Phase-II Study, Investigational New Drug (IND) 117435, Date: 01/07/13 Completed NCT02553265 Phase 2 Carbidopa Low Dose;Carbidopa High Dose
12 The Effects of Liraglutide on Sudomotor Function and Inflammation in Type 2 Diabetes Recruiting NCT03426085 Phase 2 Liraglutide 6 mg Solution for Injection
13 Ivabradine in the Management of Cardiac Autonomic Dysfunction Associated With Thoracic Radiation Therapy. Recruiting NCT03137537 Phase 2 Ivabradine;Placebo Oral Tablet
14 The Nutritional Supplement Phosphatidylserine in Patients With Familial Recruiting NCT02276716 Phase 2 Phosphatidylserine
15 Early Treatment of Paroxysmal Dysautonomia and Hypertonia for Severe Brain Injured Patients by Intrathecal Baclofen Therapy Terminated NCT00221689 Phase 2 baclofen (drug)
16 L-Dihydroxyphenylserine (L-DOPS) for Norepinephrine Deficiency: Interactions With Carbidopa and Entacapone Terminated NCT00547911 Phase 1, Phase 2 Droxidopa;Carbidopa;Entacapone
17 Controlling Hyperadrenergic Activity in Neurologic Injury Withdrawn NCT01343329 Phase 1, Phase 2 Esmolol;Propranolol
18 The Safety , Tolerability and Efficacy of Dronabinol, a Synthetic Endocannabinoid Receptor Agonist, for the Treatment of Nausea and Vomiting in Patients With Familial Dysautonomia Withdrawn NCT02608931 Phase 2 Dronabinol
19 The Safety and Tolerability of Kinetin, a Nutritional Supplement That Corrects the Splicing Defect, in Patients With Familial Dysautonomia Completed NCT02274051 Phase 1
20 Prospective Single-Arm Pilot Study for CT-Guided, Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility Recruiting NCT04121338 Phase 1 Liposomal bupivacaine
21 The Pathophysiology of Orthostatic Hypotension Active, not recruiting NCT00748059 Phase 1 phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine;clonidine,yohimbine,metoclopramide,alpha-methyldopa
22 Is Acupoints Sensation Necessary for Acu-TENS to Elicit Physiological Changes in Healthy Subjects? Unknown status NCT01804192
23 Autonomic Dysfunction in Patients With Pectus Excavatum. Unknown status NCT03346876
24 A Pilot Study Evaluating Hypotension and Autonomic Nervous System Dysfunction After Therapy With Bortezomib-containing Regimens in Subjects With Multiple Myeloma Unknown status NCT01314625
25 Autonomic Cardiovascular Neuropathy in Recently Diagnosed DM2 Patients and in Pre-Diabetes Patients Unknown status NCT02931773
26 Noninvasive Study of the Time Course of Baroreflex Sensitivity 6-Month After Acute Ischemic Stroke and the Relation of Its Changes With Post Stroke Prognosis Unknown status NCT00422474
27 A Multicenter Longitudinal Observational Study Evaluating Genotypic Association wIth Clinical Outcomes in Interventional Pain Management Modalities Unknown status NCT02485795
28 Effects of Transcutaneous Electrical Nerve Stimulation (TENS) on Arterial Stiffness and Blood Pressure in Resistant Hypertensive Individuals Unknown status NCT02365974
29 Upper- and Lower-body Resistance Exercise With and Without Blood Flow Restriction on Hemodynamics and Vascular Function Unknown status NCT03225898
30 Pain Modulation in RA - Influence of Adalimumab. A Randomized, Placebo-controlled Study Using Functional Magnetic Resonance Imaging (PARADE) Unknown status NCT01197144 adalimumab;Placebo
31 Variations of Heart Rate Variability and Skin Conductance Reveal the Influence of CV4 and Rib Raising Osteopathic Techniques on the Autonomic Nervous System: a Randomized Controlled Trial Completed NCT03142373
32 Blood Sampling for Neurochemical and Genetic Testing Completed NCT00001147
33 The Relative Prevalence and Severity of Autonomic Nervous System Dysfunction in Diabetic Patients Undergoing Retinal Surgery Completed NCT00919347
34 Plasma Catecholamine Kinetics Completed NCT00001329
35 Autonomic Dysfunction and Inflammation in Chronic Hemodialysis Patients Completed NCT00878033
36 Autonomic Responses During the Valsalva Maneuver and Deep Breathing Test Depend on the Experimental Setup Completed NCT02397681
37 Sleep, Autonomic Nervous System and Cardiorespiratory Capacity in Autism Spectrum Disorders Children Completed NCT02830022
38 Effect of Exercise Training in Autonomic Modulation in Breast Cancer Patients Treated With Doxorubicin Completed NCT02584712
39 PD2i Analysis of Heart Rate Variability in Competitive Sports Completed NCT01249248
40 Cardiovascular Variability and Heart Rate Arousal Response in Idiopathic Hypersomnia Completed NCT02913651
41 Effect of Salbutamol on Autonomic Nervous System Dysfunction of Children With Sickle Cell Disease Completed NCT04062409
42 Phase 1 Study - Focus On Stiffness Reduction, Endothelial Function and Autonomic Nervous System improVement in Patients After MI With or Without hypErtension After Cardiovascular Rehabilitation. Completed NCT02195388
43 Autonom Dysrefleksi Ved Rygmarvsskade Completed NCT01059370
44 The Identification and Characterization of Autonomic Dysfunction in Migraineurs With and Without Auras Completed NCT01080287
45 Autonomic Effects of T4 Mobilization in Asymptomatic Subjects: Randomized Clinical Trial Completed NCT02164123
46 Preoperative Evaluation of Autonomic Nervous System by Heart Rate Variability as a Predictor of Postoperative Outcome in the Patient Undergoing Major Elective Abdominal Surgery Completed NCT02375412
47 Autonomic Nervous System Dysfunction and Peripheral Neuropathy in a Cohort of Asymptomatic Juvenile Diabetic Patients (Type I): A Case-Controlled Study Completed NCT00466778
48 Positron Emission Tomographic (PET) Scanning of Sympathetic Innervation and Function in Patients With Neurocardiologic Disorders Completed NCT00001418
49 An Open-Label Pilot Trial of Cognitive Behavioral Therapy in Familial Dysautonomia Completed NCT03013777
50 Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Question 3 Completed NCT00742521

Search NIH Clinical Center for Autonomic Nervous System Disease

Genetic Tests for Autonomic Nervous System Disease

Genetic tests related to Autonomic Nervous System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Autonomic Nervous System 29

Anatomical Context for Autonomic Nervous System Disease

MalaCards organs/tissues related to Autonomic Nervous System Disease:

Heart, Kidney, Brain, Spinal Cord, Testes, Liver, Skin

Publications for Autonomic Nervous System Disease

Articles related to Autonomic Nervous System Disease:

(show top 50) (show all 83)
# Title Authors PMID Year
Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. 6
7881421 1994
Post-exercise Hypotension Produced by Supramaximal Interval Exercise is Potentiated by Angiotensin Receptor Blockers. 42
31476782 2019
Cardiac autonomic function during intradialytic exercise training. 42
31482757 2019
Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease. 42
31438878 2019
Gastroesophageal reflux disease is associated with abnormal ventricular repolarization indices. 61
31854306 2019
Epigenetic impact of the social and physical environment on brain and body. 61
31610853 2019
Effects of inspiratory muscle training on respiratory muscle strength, lung function, functional capacity and cardiac autonomic function in Parkinson's disease: Randomized controlled clinical trial protocol. 61
31090181 2019
Pelvic Electric Potential as a Marker of Autonomic Dysfunctions and Risk Factor of Neurogenic Arrhythmias in Humans. 61
30627894 2019
Evaluation of postural tachycardia syndrome (POTS). 61
29705015 2018
[Analysis of the extension of childhood expectations and evaluation of the risks of the development of diseases associated with overweight]. 61
29783222 2018
Targets and Therapeutics for Glycemic Control in Diabetes Patients on Hemodialysis. 61
30041202 2018
Neurological and neuropsychological complications in the course of chronic Whipple's disease - case report. 61
29289973 2017
Antiarrhythmic properties of atrial pacing. 61
28791857 2017
Some Non-FDA Approved Uses for Neuromodulation in Treating Autonomic Nervous System Disorders: A Discussion of the Preliminary Support. 61
27339825 2016
Seborrheic dermatitis treatment with stellate ganglion block: a case report. 61
27064785 2016
Endoscopic Findings of Small-Bowel Lesions in Familial Amyloid Polyneuropathy: A Case Report. 61
26986100 2016
[Current pharmacotherapy of the autonomic nervous system disorders]. 61
26977913 2015
[The Four-Dimensional Symptom Questionnaire (4DSQ) to assess distress, depression, anxiety and somatization in autonomic and borderline psychosomatic disorders]. 61
25591639 2014
[Sanatorium care in autonomic nervous system disorders]. 61
25176267 2014
[The primary screening of patients with autonomic disorders in outpatient clinics in Russia (START1) using the Russian version of The Four-Dimensional Symptom Questionnaire (4DSQ)]. 61
25726790 2014
Characteristic features of migraine in schoolchildren and adolescents and its relationship with autonomic nervous system disorders. 61
23771848 2013
Alterations in TH- and ChAT-immunoreactive neurons in the DMV and gastric dysmotility in an LPS-induced PD rat model. 61
23701914 2013
[Characteristics of the autonomic nervous system state in children with myopia associated with undifferentiated connective tissue dysplasia]. 61
24340615 2013
Syndromes of orthostatic intolerance: a hidden danger. 61
23216860 2013
[Vagotonía. The medical thesis of Salvador Zubirán]. 61
23227589 2012
Co-morbidities of interstitial cystitis. 61
22907988 2012
The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease. 61
23110271 2012
Obesity-related autonomic nervous system disorders are best associated with body fat mass index, a new indicator. 61
21963211 2011
A novel pharmacological approach to determining parasympathetic heart rate reserve in human subjects. 61
20861836 2010
European teaching course on autonomic nervous system disorders : reaching out to young physicians. 61
19350223 2009
Central nervous system plus autonomic nervous system disorders responsible for gastrointestinal and pancreatobiliary diseases. 61
18629642 2009
Evaluation and management of autonomic nervous system disorders. 61
18351521 2008
Autonomic function in tension-type headache. 61
18416283 2007
[Botulinum toxin type A and cholinergic system]. 61
18383744 2007
[Diagnosis and treatment of Madelung's disease]. 61
17007380 2006
Skin sympathetic adrenergic innervation: an immunofluorescence confocal study. 61
16437571 2006
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. 61
16412483 2006
[Clinical analysis of autonomic nervous system disorders in patients with psoriasis concurrent with chronic opisthorchiasis]. 61
16562741 2006
[Neuroretinitis, Parry-Romberg syndrome, and scleroderma]. 61
16249769 2005
May fever trigger ventricular fibrillation? 61
16943953 2005
[Therapy for patients with mental and autonomic nervous system disorders in Parkinson's disease]. 61
13677892 2003
Age-related differences in the side effect profile of citalopram. 61
12691792 2003
[Clinical course of autonomic nervous system disorders in veterans with consequences of combat mild brain injury]. 61
12616732 2003
Comprehensive study of autonomic function in a population with primary Sjögren's syndrome. No evidence of autonomic involvement. 61
12508393 2003
Other noncosmetic uses of BOTOX. 61
12195265 2002
Other noncosmetic uses of BOTOX. 61
11474744 2001
[Acupuncture correction of autonomic nervous system disorders in patients with bronchial asthma]. 61
11490414 2001
The treatment of neurogenic orthostatic hypotension with 3,4-DL-threo-dihydroxyphenylserine: a randomized, placebo-controlled, crossover trial. 61
10599797 1999
Autonomic nervous system disorders in stroke. 61
10638806 1999
Evaluation of the cardiac autonomic nervous system in spontaneously non-insulin-dependent diabetic rats by 123I-metaiodobenzylguanidine imaging. 61
10202944 1999

Variations for Autonomic Nervous System Disease

ClinVar genetic disease variations for Autonomic Nervous System Disease:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 DRD4 NM_000797.4(DRD4):c.235_247del (p.Ala79fs)deletion Pathogenic 16767 rs587776842 11:637537-637549 11:637537-637549

Expression for Autonomic Nervous System Disease

Search GEO for disease gene expression data for Autonomic Nervous System Disease.

Pathways for Autonomic Nervous System Disease

GO Terms for Autonomic Nervous System Disease

Cellular components related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TTR TAC1 REN PPY NPY NPS
2 extracellular space GO:0005615 9.4 TTR TAC1 REN PPY NPY NGF

Biological processes related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.91 TACR1 TAC1 PPY NPY NPS INS
2 inflammatory response GO:0006954 9.89 TRPV1 TACR1 TAC1 CALCA ADAM8
3 cellular protein metabolic process GO:0044267 9.83 TTR INS CALCA ALB
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.73 TRPV1 TACR1 TAC1 CALCA
5 amyloid-beta metabolic process GO:0050435 9.58 REN ACE
6 positive regulation of acute inflammatory response GO:0002675 9.57 TAC1 ADAM8
7 positive regulation of synaptic transmission, GABAergic GO:0032230 9.56 TAC1 NPS
8 negative regulation of heart rate GO:0010459 9.55 TRPV1 TAC1
9 neuropeptide signaling pathway GO:0007218 9.55 TAC1 PPY NPY NPS CALCA
10 angiotensin maturation GO:0002003 9.54 REN ACE
11 cellular response to nerve growth factor stimulus GO:1990090 9.54 TRPV1 TAC1 CALCA
12 tachykinin receptor signaling pathway GO:0007217 9.51 TACR1 TAC1
13 feeding behavior GO:0007631 9.5 NPY GCG CALCA
14 positive regulation of action potential GO:0045760 9.48 TAC1 NPS
15 negative regulation of protein oligomerization GO:0032460 9.46 INS ALB
16 detection of abiotic stimulus GO:0009582 9.4 TACR1 TAC1
17 response to pain GO:0048265 9.26 TRPV1 TACR1 TAC1 CALCA
18 regulation of blood pressure GO:0008217 9.02 TAC1 REN NPY CALCA ACE

Molecular functions related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.7 TTR TRPV1 INS GCG DRD4 CALCA
2 drug binding GO:0008144 9.43 DRD4 ALB ACE
3 signaling receptor binding GO:0005102 9.35 REN NPY NGF GCG CALCA
4 hormone activity GO:0005179 9.1 TTR PPY NPY INS GCG CALCA

Sources for Autonomic Nervous System Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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