Aliases & Classifications for Autonomic Nervous System Disease

MalaCards integrated aliases for Autonomic Nervous System Disease:

Name: Autonomic Nervous System Disease 12 15
Autonomic Nervous System Disorders 43 73
Abnormality of the Autonomic Nervous System 29
Autonomic Nervous System Dysfunction 6
Autonomic Nervous System Disorder 12
Autonomic Nervous System Diseases 76

Classifications:



External Ids:

Disease Ontology 12 DOID:11465
ICD9CM 35 337.1
ICD10 33 G90 G90.8 G99.1

Summaries for Autonomic Nervous System Disease

MedlinePlus : 43 Your autonomic nervous system is the part of your nervous system that controls involuntary actions, such as the beating of your heart and the widening or narrowing of your blood vessels. When something goes wrong in this system, it can cause serious problems, including Blood pressure problems Heart problems Trouble with breathing and swallowing Erectile dysfunction in men Autonomic nervous system disorders can occur alone or as the result of another disease, such as Parkinson's disease, alcoholism and diabetes. Problems can affect either part of the system, as in complex regional pain syndromes, or all of the system. Some types are temporary, but many worsen over time. When they affect your breathing or heart function, these disorders can be life-threatening. Some autonomic nervous system disorders get better when an underlying disease is treated. Often, however, there is no cure. In that case, the goal of treatment is to improve symptoms. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Autonomic Nervous System Disease, also known as autonomic nervous system disorders, is related to central hypoventilation syndrome, congenital and algoneurodystrophy, and has symptoms including back pain, constipation and diarrhea. An important gene associated with Autonomic Nervous System Disease is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and brain, and related phenotypes are behavior/neurological and normal

Wikipedia : 76 Dysautonomia or autonomic dysfunction is a condition in which the autonomic nervous system (ANS) does... more...

Related Diseases for Autonomic Nervous System Disease

Diseases related to Autonomic Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 central hypoventilation syndrome, congenital 31.1 ASCL1 EDNRB PHOX2A PHOX2B
2 algoneurodystrophy 30.3 CALCA NGF
3 reflex sympathetic dystrophy 30.1 CALCA CHSY1 NPS
4 burns 30.1 ALB INS TTR
5 burning mouth syndrome 30.0 NGF TAC1
6 parkinson disease, late-onset 28.8 DBH DRD4 NGF TAC1
7 autonomic dysfunction 11.5
8 autonomic peripheral neuropathy 11.2
9 multiple system atrophy 1 11.0
10 duodenal somatostatinoma 10.7 CALCA INS
11 burn scar 10.7 CALCA TAC1
12 retinitis pigmentosa 68 10.6 NPS TAC1
13 epicondylitis 10.6 NPS TAC1
14 severe nonproliferative diabetic retinopathy 10.6 ALB INS
15 vasomotor rhinitis 10.6 CALCA TAC1
16 urticaria pigmentosa 10.6 CALCA TAC1
17 paramyloidosis 10.6 ALB TTR
18 bullous impetigo 10.5 CALCA EDNRB
19 bladder neck obstruction 10.5 TAC1 TTR
20 somatostatinoma 10.5 CALCA INS
21 background diabetic retinopathy 10.5 ALB INS
22 neuroschistosomiasis 10.5 NGF TAC1
23 prurigo nodularis 10.5 NGF TAC1
24 kwashiorkor 10.5 ALB TTR
25 chronic ulcer of skin 10.5 ALB TTR
26 marasmus 10.4 ALB TTR
27 impetigo 10.4 CALCA EDNRB
28 decubitus ulcer 10.4 ALB TTR
29 exotropia 10.4 PHOX2A PHOX2B
30 aspiration pneumonia 10.4 ALB TAC1
31 amyloid tumor 10.4 CALCA TTR
32 postural hypotension 10.4 DBH INS
33 aleutian mink disease 10.4 ALB TTR
34 colonic disease 10.4 ASCL1 EDNRB PHOX2B
35 prolactin producing pituitary tumor 10.4 CALCA NGF
36 dental pulp disease 10.3 NPS TAC1
37 hyperthyroxinemia 10.3 ALB TTR
38 multiple endocrine neoplasia, type iib 10.3 CALCA EDNRB
39 fetal erythroblastosis 10.2 ALB INS
40 constipation 10.2 CALCA EDNRB TAC1
41 noma 10.2 ALB INS
42 early-onset schizophrenia 10.2 DBH DRD4 INS
43 hypoglycemic coma 10.1 HBA2 INS
44 amyloidosis, hereditary, transthyretin-related 10.1 DBH TTR
45 type 1 diabetes mellitus 7 10.1 HBA2 INS
46 type 1 diabetes mellitus 11 10.1 HBA2 INS
47 intestinal disease 10.1 ALB EDNRB TAC1
48 goldberg-shprintzen syndrome 10.0 ASCL1 EDNRB NGF
49 autonomic neuropathy 10.0 ALB INS NGF
50 paine syndrome 10.0 NGF TAC1

Comorbidity relations with Autonomic Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Hypertension, Essential Hypothyroidism
Ischemic Heart Disease Parkinson Disease, Late-Onset
Peripheral Vascular Disease

Graphical network of the top 20 diseases related to Autonomic Nervous System Disease:



Diseases related to Autonomic Nervous System Disease

Symptoms & Phenotypes for Autonomic Nervous System Disease

UMLS symptoms related to Autonomic Nervous System Disease:


back pain, constipation, diarrhea, headache, mydriasis, pain, rectal pain, sciatica, seizures, syncope, tremor, vomiting, chronic pain, lightheadedness, decrease in appetite, rectal tenesmus, warm skin, dry throat, palpitations - fluttering, pounding heart, syncope, effort, hyperemesis, anal pain, vomiting in newborn, blackout - symptom, vertigo/dizziness, increased sweating, vomiting alone, sleeplessness

MGI Mouse Phenotypes related to Autonomic Nervous System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ASCL1 CHSY1 DBH DRD4 EDNRB INS
2 normal MP:0002873 9.5 ALB ASCL1 DBH INS NGF PHOX2B
3 vision/eye MP:0005391 9.28 ASCL1 CHSY1 DBH DRD4 EDNRB INS

Drugs & Therapeutics for Autonomic Nervous System Disease

Drugs for Autonomic Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 504)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
2
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
3
Zolpidem Approved Phase 4,Not Applicable 82626-48-0 5732
4
Acetylcholine Approved Phase 4,Not Applicable 51-84-3 187
5
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
6
Midodrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 133163-28-7, 42794-76-3 4195
7
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 37350-58-6, 51384-51-1 4171
8
Bupivacaine Approved, Investigational Phase 4,Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
9
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
10
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-92-7 6047
11
Propranolol Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 525-66-6 4946
12
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
13
Acetylcarnitine Approved, Investigational Phase 4 3040-38-8 1
14
Bisoprolol Approved Phase 4 66722-44-9 2405
15
Fludrocortisone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 127-31-1 31378
16
Gabapentin Approved, Investigational Phase 4,Not Applicable 60142-96-3 3446
17
gamma-Aminobutyric acid Approved, Investigational Phase 4,Not Applicable 56-12-2 119
18
Furosemide Approved, Vet_approved Phase 4,Not Applicable 54-31-9 3440
19
Indapamide Approved Phase 4 26807-65-8 3702
20
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
21
Droxidopa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 23651-95-8 443940
22
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
23
Vitamin C Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 50-81-7 5785 54670067
24 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 1406-16-2
27
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
28 Antipsychotic Agents Phase 4,Phase 3,Not Applicable
29 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
30 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Dopamine Antagonists Phase 4,Phase 3,Phase 1
32 GABA Agents Phase 4,Early Phase 1,Not Applicable
33 GABA Agonists Phase 4
34 GABA-A Receptor Agonists Phase 4
35 Hypnotics and Sedatives Phase 4,Phase 1,Early Phase 1,Not Applicable
36 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Psychotropic Drugs Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
38 Serotonin Agents Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Serotonin Antagonists Phase 4
40 Tranquilizing Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
41 abobotulinumtoxinA Phase 4,Not Applicable
42 Botulinum Toxins Phase 4,Not Applicable
43 Botulinum Toxins, Type A Phase 4,Not Applicable
44 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Neuromuscular Agents Phase 4,Not Applicable
46 onabotulinumtoxinA Phase 4,Not Applicable
47 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Anesthetics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Adrenergic Antagonists Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 538)
# Name Status NCT ID Phase Drugs
1 Risperidone and Zotepine in the Treatment of Delirium Unknown status NCT00622011 Phase 4 Risperidone and Zolpidem for delirium
2 Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study) Unknown status NCT01621464 Phase 4
3 Botulinum A Toxin in Patients With Parkinson's Disease Unknown status NCT00822913 Phase 4 Intravesical injection of Botulinum A toxin
4 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4 BOTOX
5 Duodenal Levodopa Infusion, Quality of Life and Autonomic Nervous System in Parkinson's Disease Completed NCT00914134 Phase 4 Levodopa infusion
6 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
7 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
8 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Completed NCT01823770 Phase 4 Rotigotine;Placebo patchs
9 Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy Completed NCT01524861 Phase 4 Placebo;alpha-lipoic acid;L-acetyl carnitine
10 Prophylactic Administration of Vitamin C in Wrist Fractures Completed NCT00296868 Phase 4 ascorbic acid (vitamin C) versus placebo
11 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4 Propranolol
12 Treatment and Prognosis of Neurogenic Orthostatic Hypotension : A Prospective Randomized Study Completed NCT02308124 Phase 4 Midodrine;Pyridostigmine Bromide;Midodrine + pyridostigmine
13 Tilt-Table Study of the Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01518946 Phase 4 Midodrine HCl;Placebo
14 Clinical Efficacy of Midodrine in Symptomatic Orthostatic Hypotension Completed NCT01515865 Phase 4 Midodrine HCl;Placebo
15 Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension Completed NCT00555880 Phase 4 Midodrine hydrochloride;Placebo
16 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
17 Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS) Completed NCT02171988 Phase 4 Propranolol;Bisoprolol;Propranolol+pyridostigmine;Bisoprolol+pyridostgmine
18 Clinical Trial for the Prevention of Vasovagal Syncope Completed NCT00118482 Phase 4 fludrocortisone acetate
19 Restore Claims Characterization Study Completed NCT00200122 Phase 4
20 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed NCT02265848 Phase 4
21 A Study Of Lidocaine Patch 5% Alone, Gabapentin Alone, And Lidocaine Patch 5% And Gabapentin In Combination For The Relief Of Pain In Patients With Diverse Peripheral Neuropathic Pain Conditions Completed NCT00904202 Phase 4 Placebo Capsules + Placebo Patch;Placebo capsules + Lidoderm®;Gabapentin + Placebo;Gabapentin + Lidoderm®;Gabapentin 300 mg capsules 1800 mg/day + placebo patch;Gabapentin 1800 mg/day + Lidoderm patch
22 Renal Denervation in Diabetic Nephropathy Completed NCT01588795 Phase 4 Standardized antiproteinuric medication regimen includes an angiotensin receptor blocker , a diuretic , 25OH vitamin D3 and a statin
23 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
24 Effects of DPP4 Inhibitor Versus SGLT2 Inhibitor Recruiting NCT03178591 Phase 4 vildagliptin;Dapagliflozin
25 Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH Recruiting NCT03350659 Phase 4 Midodrine;Atomoxetine
26 Dawn Simulation and Postural Hypotension Recruiting NCT02632318 Phase 4
27 Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects Recruiting NCT02123056 Phase 4 Metoprolol;Matching Placebo
28 Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV Recruiting NCT01456481 Phase 4 midodrine hydrochloride;matching placebo
29 Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome Recruiting NCT03291197 Phase 4 Suprascapular and median nerve blocks
30 Rotigotine Effect on Nocturnal Hypokinesia Compares to Placebo Control: A Quantitative Assessment by Wearable Sensors Active, not recruiting NCT03098368 Phase 4 Rotigotine;Placebo
31 MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study Active, not recruiting NCT03226119 Phase 4
32 Brain Perfusion & Oxygenation in Parkinson's Disease With NOH Not yet recruiting NCT03229174 Phase 4 Droxidopa;Placebo
33 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4 midodrine hydrochloride (ProAmatine®)
34 Surgical Treatment Of Complex Regional Pain Syndrome Type II (CRPS II) Unknown status NCT01392599 Phase 3
35 Clinical Trial on the Effectiveness of Traditional Chinese Medicinal Mixture in Parkinson Disease Unknown status NCT00629161 Phase 2, Phase 3 Traditional Chinese Medicinal Mixture (composed of Roucongrong and adjuvant);placebo
36 Acupuncture for Post-stroke Shoulder-hand Syndrome Unknown status NCT02011854 Phase 2, Phase 3
37 RCT :Thoracic Sympathetic Block for the Treatment of Complex Regional Pain Syndrome I of the Upper Limb Unknown status NCT01612364 Phase 3
38 Analysis of Photoplethysmographic Signal in Lumbar Sympathetic Block Unknown status NCT01134289 Phase 3
39 Intravenous Immunoglobulins in Complex-regional Pain Syndrome Unknown status NCT00949065 Phase 3
40 The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia Completed NCT01987219 Phase 3 Albuterol-sulphate;Ipratropium-bromide
41 Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia Completed NCT01212484 Phase 3 Carbidopa;Placebo
42 Clinical Trial to Measure the Maximun HR After ReConnect ® Supplementation vs. Placebo in CFS. Completed NCT02063126 Phase 2, Phase 3
43 Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis Completed NCT00409175 Phase 2, Phase 3 Fx-1006A;Placebo
44 The Effect of Diet on Chronic Inflammation and Related Disorders Following Spinal Cord Injury Completed NCT02099890 Phase 3
45 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) Completed NCT01132326 Phase 3 Droxidopa
46 A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa Completed NCT00782340 Phase 3 Placebo;Droxidopa
47 Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00633880 Phase 3 Placebo;Droxidopa
48 Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Completed NCT01522235 Phase 2, Phase 3 Double blinded IVIg
49 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3 Droxidopa;Placebo
50 Clinical Trial on the Effectiveness of Herbal Medicinal Mixture in Parkinson Disease Completed NCT00656253 Phase 2, Phase 3 Herbal Medicinal Mixture (Roucongrong, Heshouwu etc.);Placebo

Search NIH Clinical Center for Autonomic Nervous System Disease

Genetic Tests for Autonomic Nervous System Disease

Genetic tests related to Autonomic Nervous System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Autonomic Nervous System 29

Anatomical Context for Autonomic Nervous System Disease

MalaCards organs/tissues related to Autonomic Nervous System Disease:

41
Heart, Spinal Cord, Brain, Testes, Liver, Bone, Cortex

Publications for Autonomic Nervous System Disease

Articles related to Autonomic Nervous System Disease:

# Title Authors Year
1
Characteristic features of migraine in schoolchildren and adolescents and its relationship with autonomic nervous system disorders. ( 23771848 )
2013
2
The characteristics of autonomic nervous system disorders in burning mouth syndrome and Parkinson disease. ( 23110271 )
2012
3
Autonomic nervous system disorders and reflex sympathetic dystrophy in lightning and electrical injuries. ( 8848658 )
1995

Variations for Autonomic Nervous System Disease

ClinVar genetic disease variations for Autonomic Nervous System Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 DRD4 NM_000797.3(DRD4): c.235_247delGCCGACCTCCTCC (p.Ala79Serfs) deletion Pathogenic rs587776842 GRCh38 Chromosome 11, 637539: 637551
2 DRD4 NM_000797.3(DRD4): c.235_247delGCCGACCTCCTCC (p.Ala79Serfs) deletion Pathogenic rs587776842 GRCh37 Chromosome 11, 637539: 637551

Expression for Autonomic Nervous System Disease

Search GEO for disease gene expression data for Autonomic Nervous System Disease.

Pathways for Autonomic Nervous System Disease

Pathways related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.46 ALB ASCL1 INS
2 11.23 ASCL1 NGF PHOX2A PHOX2B TAC1
3 10.78 ALB INS TTR

GO Terms for Autonomic Nervous System Disease

Cellular components related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 ALB CALCA DBH HBA2 INS NGF
2 extracellular region GO:0005576 9.32 ALB CALCA CHSY1 DBH HBA2 INS

Biological processes related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 CALCA INS NGF TTR
2 negative regulation of apoptotic process GO:0043066 9.89 ALB ASCL1 EDNRB INS NGF
3 cell-cell signaling GO:0007267 9.86 CALCA INS NGF TAC1
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.8 CALCA EDNRB TAC1
5 cellular protein metabolic process GO:0044267 9.73 ALB CALCA INS TTR
6 neuropeptide signaling pathway GO:0007218 9.72 CALCA NPS TAC1
7 positive regulation of neuron differentiation GO:0045666 9.7 ASCL1 NGF PHOX2B
8 peripheral nervous system development GO:0007422 9.64 EDNRB NGF
9 response to amphetamine GO:0001975 9.64 DBH DRD4
10 positive regulation of blood vessel diameter GO:0097755 9.63 CALCA INS
11 dopaminergic neuron differentiation GO:0071542 9.63 PHOX2A PHOX2B
12 regulation of blood pressure GO:0008217 9.63 CALCA EDNRB TAC1
13 negative regulation of ossification GO:0030279 9.62 CALCA CHSY1
14 vasodilation GO:0042311 9.61 CALCA EDNRB
15 negative regulation of protein secretion GO:0050709 9.61 DRD4 INS
16 glial cell differentiation GO:0010001 9.6 ASCL1 PHOX2B
17 behavioral response to ethanol GO:0048149 9.59 DBH DRD4
18 positive regulation of ossification GO:0045778 9.58 CALCA TAC1
19 positive regulation of renal sodium excretion GO:0035815 9.57 EDNRB TAC1
20 positive regulation of synaptic transmission, GABAergic GO:0032230 9.54 NPS TAC1
21 enteric nervous system development GO:0048484 9.51 EDNRB PHOX2B
22 sympathetic ganglion development GO:0061549 9.48 ASCL1 PHOX2B
23 positive regulation of action potential GO:0045760 9.4 NPS TAC1
24 noradrenergic neuron differentiation GO:0003357 9.37 PHOX2A PHOX2B
25 fear response GO:0042596 9.32 DBH DRD4
26 noradrenergic neuron development GO:0003358 9.26 ASCL1 PHOX2B
27 parasympathetic nervous system development GO:0048486 9.16 PHOX2A PHOX2B
28 sympathetic nervous system development GO:0048485 9.13 ASCL1 PHOX2A PHOX2B
29 response to pain GO:0048265 8.92 CALCA DBH EDNRB TAC1
30 G-protein coupled receptor signaling pathway GO:0007186 10.05 CALCA DRD4 EDNRB INS NPS TAC1

Molecular functions related to Autonomic Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA INS TTR

Sources for Autonomic Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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