MCID: ATN003
MIFTS: 37

Autonomic Nervous System Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Autonomic Nervous System Neoplasm

MalaCards integrated aliases for Autonomic Nervous System Neoplasm:

Name: Autonomic Nervous System Neoplasm 12 15 74
Tumor of Autonomic Nervous System 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2621
NCIt 51 C5112
UMLS 74 C1332356

Summaries for Autonomic Nervous System Neoplasm

Disease Ontology : 12 A peripheral nervous system neoplasm that is located in the autonomic nervous system.

MalaCards based summary : Autonomic Nervous System Neoplasm, also known as tumor of autonomic nervous system, is related to neuroblastoma 1 and parameningeal embryonal rhabdomyosarcoma. An important gene associated with Autonomic Nervous System Neoplasm is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. Affiliated tissues include brain, lung and thyroid, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Autonomic Nervous System Neoplasm

Diseases in the Autonomic Nervous System Neoplasm family:

Autonomic Nervous System Benign Neoplasm

Diseases related to Autonomic Nervous System Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 1 11.2
2 parameningeal embryonal rhabdomyosarcoma 10.5 ALK TP53
3 prolactin producing pituitary tumor 10.5 NGF NTRK1 TP53
4 central nervous system benign neoplasm 10.5 ENO2 MYCN TP53
5 cerebral neuroblastoma 10.5 ENO2 NGF TP53
6 cervical neuroblastoma 10.5 MYCN VIP
7 bone ewing's sarcoma 10.5 ENO2 MYC MYCN
8 causalgia 10.5 ENO2 NGF NTRK1
9 olfactory neuroblastoma 10.5 ENO2 NTRK1 NTRK2
10 extracranial neuroblastoma 10.5 MYCN VIP
11 meningeal melanomatosis 10.5 ENO2 NGF TP53
12 adult medulloblastoma 10.5 ENO2 MYCN TP53
13 brain injury 10.5 BDNF CASP3 ENO2
14 neuropathy, hereditary sensory and autonomic, type v 10.5 BDNF NGF NTRK1
15 neonatal hypoxic and ischemic brain injury 10.5 BDNF ENO2 TH
16 hereditary sensory neuropathy 10.5 NGF NTRK1 NTRK2
17 childhood medulloblastoma 10.5 MYC MYCN TP53
18 adrenal neuroblastoma 10.5 ENO2 MYCN
19 infratentorial cancer 10.4 MYC MYCN TP53
20 short-rib thoracic dysplasia 4 with or without polydactyly 10.4 CASP3 TP53
21 traumatic brain injury 10.4 BDNF CASP3 ENO2
22 germ cell and embryonal cancer 10.4 ENO2 MYC TP53
23 rare adenocarcinoma of the breast 10.4 AKT1 TP53
24 pharynx squamous cell carcinoma 10.4 AKT1 CASP3
25 connective tissue cancer 10.4 AKT1 ENO2 TP53
26 rhabdomyosarcoma 2 10.4 ALK ENO2 MYCN TH
27 megaesophagus 10.4 MYC TP53 VIP
28 rhabdomyosarcoma 10.4 ALK ENO2 MYCN TP53
29 cerebral primitive neuroectodermal tumor 10.4 ENO2 MYC MYCN TP53
30 medullomyoblastoma 10.4 ENO2 MYC MYCN TP53
31 supratentorial cancer 10.4 AKT1 CASP3 TP53
32 autonomic nervous system benign neoplasm 10.4 ENO2 MYCN NTRK1 VIP
33 cerebrum cancer 10.4 AKT1 CASP3 TP53
34 achalasia 10.4 ENO2 TP53 VIP
35 uterine anomalies 10.4 AKT1 CASP3 TP53
36 bladder disease 10.4 AKT1 NGF TP53
37 interstitial cystitis 10.4 BDNF KNG1 NGF
38 insensitivity to pain, congenital, with anhidrosis 10.4 BDNF NTRK1
39 differentiated thyroid carcinoma 10.4 ALK NTRK1 TP53
40 stomach disease 10.4 AKT1 CASP3 TP53
41 status epilepticus 10.4 BDNF CASP3 ENO2 NTRK2
42 central hypoventilation syndrome, congenital 10.4 BDNF PHOX2B TH
43 nasopharyngeal disease 10.4 AKT1 CASP3 MYC TP53
44 pharynx cancer 10.4 AKT1 CASP3 MYC TP53
45 cervix disease 10.4 AKT1 CASP3 MYC TP53
46 askin's tumor 10.4 ENO2 MYC MYCN NGF NTRK1
47 leukocyte disease 10.4 AKT1 CASP3 MYC TP53
48 respiratory system disease 10.4 AKT1 ALK CASP3 TP53
49 female reproductive system disease 10.4 AKT1 CASP3 TP53
50 male reproductive organ cancer 10.4 AKT1 CASP3 MYC TP53

Graphical network of the top 20 diseases related to Autonomic Nervous System Neoplasm:



Diseases related to Autonomic Nervous System Neoplasm

Symptoms & Phenotypes for Autonomic Nervous System Neoplasm

MGI Mouse Phenotypes related to Autonomic Nervous System Neoplasm:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.45 AKT1 ALK BDNF CASP3 CNTN6 ENO2
2 growth/size/body region MP:0005378 10.39 AKT1 ALK BDNF CASP3 ENO2 KNG1
3 cellular MP:0005384 10.28 AKT1 BDNF CASP3 ENO2 MYC MYCN
4 mortality/aging MP:0010768 10.28 AKT1 ALK BDNF CASP3 MYC MYCN
5 nervous system MP:0003631 10.28 AKT1 ALK BDNF CASP3 CNTN6 ENO2
6 homeostasis/metabolism MP:0005376 10.26 AKT1 ALK BDNF CASP3 MYC MYCN
7 endocrine/exocrine gland MP:0005379 10.18 AKT1 ALK BDNF CASP3 MYC NTRK2
8 integument MP:0010771 10.11 AKT1 ALK BDNF CASP3 MYC NGF
9 normal MP:0002873 10.1 AKT1 BDNF MYC MYCN NGF NTRK1
10 hearing/vestibular/ear MP:0005377 10.04 BDNF CASP3 MYC NTRK1 NTRK2 NUMBL
11 no phenotypic analysis MP:0003012 9.97 BDNF CASP3 MYC MYCN NGF NTRK1
12 reproductive system MP:0005389 9.85 AKT1 ALK BDNF CASP3 MYC MYCN
13 respiratory system MP:0005388 9.7 AKT1 ALK BDNF CASP3 ENO2 MYCN
14 pigmentation MP:0001186 9.65 ALK CASP3 MYC NTRK1 TP53
15 vision/eye MP:0005391 9.36 ALK BDNF CASP3 MYCN NGF NTRK1

Drugs & Therapeutics for Autonomic Nervous System Neoplasm

Search Clinical Trials , NIH Clinical Center for Autonomic Nervous System Neoplasm

Genetic Tests for Autonomic Nervous System Neoplasm

Anatomical Context for Autonomic Nervous System Neoplasm

MalaCards organs/tissues related to Autonomic Nervous System Neoplasm:

42
Brain, Lung, Thyroid, Colon, Bone, Breast, Pancreas

The Foundational Model of Anatomy Ontology organs/tissues related to Autonomic Nervous System Neoplasm:

20
The Autonomic Nervous System

Publications for Autonomic Nervous System Neoplasm

Variations for Autonomic Nervous System Neoplasm

Expression for Autonomic Nervous System Neoplasm

Search GEO for disease gene expression data for Autonomic Nervous System Neoplasm.

Pathways for Autonomic Nervous System Neoplasm

Pathways related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 AKT1 ALK BDNF CASP3 MYC NGF
2
Show member pathways
13.53 AKT1 ALK BDNF MYC NGF NTRK1
3
Show member pathways
13.39 AKT1 ALK BDNF CASP3 NGF NTRK1
4
Show member pathways
13.26 AKT1 ALK BDNF CASP3 NGF NTRK1
5
Show member pathways
13.05 AKT1 BDNF NGF NTRK1 NTRK2 TP53
6
Show member pathways
13.04 AKT1 ALK BDNF NGF NTRK1 NTRK2
7
Show member pathways
12.95 AKT1 BDNF CASP3 MYC NGF NTRK1
8
Show member pathways
12.84 AKT1 CASP3 MYC NTRK1 TP53
9 12.83 AKT1 ALK CASP3 MYC NTRK1 TP53
10
Show member pathways
12.78 AKT1 CASP3 MYC NGF NTRK1 TP53
11
Show member pathways
12.72 AKT1 BDNF NGF NTRK1 NTRK2
12
Show member pathways
12.67 AKT1 BDNF CASP3 NGF NTRK1 NTRK2
13
Show member pathways
12.62 AKT1 BDNF NGF NTRK1 NTRK2
14 12.53 ENO2 MYCN NGF NTRK1 NTRK2 TH
15
Show member pathways
12.45 AKT1 CASP3 MYC TH
16 12.43 AKT1 BDNF CASP3 MYC NGF NTRK1
17
Show member pathways
12.42 AKT1 CASP3 NTRK1 NTRK2 TP53
18
Show member pathways
12.38 ALK BDNF NGF NTRK1 NTRK2
19 12.27 AKT1 CASP3 MYC TP53
20 12.23 MYC MYCN NTRK1 TP53
21
Show member pathways
12.23 AKT1 BDNF MYC NGF NTRK1 NTRK2
22
Show member pathways
12.19 AKT1 CASP3 MYC NTRK1 NTRK2 TP53
23 12.17 AKT1 CASP3 MYC TP53
24 12.13 AKT1 CASP3 MYC TP53
25 12.09 BDNF CASP3 NGF NTRK2 PHOX2B TH
26 12.07 AKT1 CASP3 MYC NTRK1 NTRK2 TP53
27 12 BDNF CASP3 MYC TP53
28 11.98 BDNF NGF NTRK1 NTRK2
29
Show member pathways
11.92 AKT1 CASP3 MYC NGF NTRK1 TP53
30 11.86 AKT1 CASP3 MYC TP53
31 11.77 BDNF NGF TH
32 11.72 AKT1 CASP3 TP53
33 11.7 AKT1 MYC NTRK1 TP53
34
Show member pathways
11.65 BDNF NGF NTRK1 NTRK2
35
Show member pathways
11.59 AKT1 BDNF CASP3 NGF TP53
36 11.59 AKT1 BDNF CASP3 NGF NTRK1 NTRK2
37 11.56 AKT1 CASP3 TP53
38 11.56 AKT1 CASP3 MYC TP53
39 11.54 AKT1 CNTN6 MYC MYCN TP53
40 11.5 AKT1 CASP3 MYC TP53
41 11.34 AKT1 BDNF NTRK2
42 11.3 AKT1 CASP3 NGF
43 11 ALK BDNF NGF NTRK1 NTRK2
44 10.9 BDNF CASP3 NTRK2
45
Show member pathways
10.78 NGF NTRK1 NTRK2
46 10.67 BDNF NGF NTRK1 NTRK2 VIP
47 10.35 MYC MYCN

GO Terms for Autonomic Nervous System Neoplasm

Cellular components related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.35 BDNF NGF NTRK1 NTRK2 TH
2 axon GO:0030424 9.1 BDNF CNTN6 NGF NTRK1 NTRK2 TH

Biological processes related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.95 AKT1 CASP3 KNG1 NGF TP53
2 protein autophosphorylation GO:0046777 9.87 AKT1 ALK NTRK1 NTRK2
3 positive regulation of gene expression GO:0010628 9.85 AKT1 MYC MYCN NGF NTRK2 TP53
4 cytokine-mediated signaling pathway GO:0019221 9.83 AKT1 CASP3 MYC NUMBL TP53
5 memory GO:0007613 9.81 BDNF NGF TH
6 negative regulation of neuron apoptotic process GO:0043524 9.81 BDNF NGF NTRK1 NTRK2
7 cellular response to organic cyclic compound GO:0071407 9.8 AKT1 CASP3 MYC
8 cellular response to drug GO:0035690 9.8 MYC TH TP53
9 neuron differentiation GO:0030182 9.8 CASP3 CNTN6 NTRK2 PHOX2B
10 nervous system development GO:0007399 9.8 AKT1 ALK BDNF CNTN6 NTRK1 NTRK2
11 positive regulation of synapse assembly GO:0051965 9.78 BDNF NTRK1 NTRK2
12 cellular response to growth factor stimulus GO:0071363 9.77 AKT1 NTRK1 TH
13 learning or memory GO:0007611 9.76 CASP3 NTRK1 VIP
14 positive regulation of protein phosphorylation GO:0001934 9.75 AKT1 NTRK1 NTRK2
15 response to nicotine GO:0035094 9.7 CASP3 NTRK1 TH
16 striated muscle cell differentiation GO:0051146 9.65 AKT1 CASP3
17 nerve development GO:0021675 9.65 BDNF NGF
18 cellular response to nerve growth factor stimulus GO:1990090 9.65 AKT1 NTRK1 NTRK2
19 positive regulation of mitochondrial membrane potential GO:0010918 9.64 AKT1 MYC
20 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.63 MYCN TP53
21 cellular response to nicotine GO:0071316 9.62 NTRK1 TH
22 positive regulation of collateral sprouting GO:0048672 9.61 BDNF NGF
23 positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997 9.6 BDNF NTRK2
24 response to gamma radiation GO:0010332 9.58 MYC TP53 TRIM13
25 mechanoreceptor differentiation GO:0042490 9.56 NTRK1 NTRK2
26 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.55 ALK BDNF NGF NTRK1 NTRK2
27 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 9.54 BDNF NTRK2
28 nerve growth factor signaling pathway GO:0038180 9.5 BDNF NGF NTRK1
29 negative regulation of apoptotic process GO:0043066 9.5 AKT1 CASP3 MYC NGF NTRK1 TP53
30 neurotrophin signaling pathway GO:0038179 9.46 NTRK1 NTRK2
31 neurotrophin TRK receptor signaling pathway GO:0048011 9.02 BDNF CASP3 NGF NTRK1 NTRK2

Molecular functions related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.5 CASP3 CD177 TP53
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 ALK NTRK1 NTRK2
3 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
4 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2
5 protein binding GO:0005515 10.19 AKT1 ALK CASP3 CD177 ENO2 KNG1

Sources for Autonomic Nervous System Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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