MCID: ATN003
MIFTS: 36

Autonomic Nervous System Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Autonomic Nervous System Neoplasm

MalaCards integrated aliases for Autonomic Nervous System Neoplasm:

Name: Autonomic Nervous System Neoplasm 12 15 73
Tumor of Autonomic Nervous System 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2621
NCIt 50 C5112
UMLS 73 C1332356

Summaries for Autonomic Nervous System Neoplasm

Disease Ontology : 12 A peripheral nervous system neoplasm that is located in the autonomic nervous system.

MalaCards based summary : Autonomic Nervous System Neoplasm, also known as tumor of autonomic nervous system, is related to neuroblastoma and parameningeal embryonal rhabdomyosarcoma. An important gene associated with Autonomic Nervous System Neoplasm is BACE1 (Beta-Secretase 1), and among its related pathways/superpathways are Akt Signaling and PI3K-Akt signaling pathway. Affiliated tissues include lung, brain and bone, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Autonomic Nervous System Neoplasm

Diseases in the Autonomic Nervous System Neoplasm family:

Autonomic Nervous System Benign Neoplasm

Diseases related to Autonomic Nervous System Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 31.3 AKT1 ALK BACE1 CASP3 ENO2 MYC
2 parameningeal embryonal rhabdomyosarcoma 10.3 ALK TP53
3 autonomic nervous system benign neoplasm 10.3 ENO2 MYCN NTRK1
4 prolactin producing pituitary tumor 10.3 NGF NTRK1 TP53
5 central nervous system benign neoplasm 10.3 ENO2 MYCN TP53
6 cerebral neuroblastoma 10.3 ENO2 NGF TP53
7 adult medulloblastoma 10.3 ENO2 MYCN TP53
8 meningeal melanomatosis 10.3 ENO2 NGF TP53
9 short-rib thoracic dysplasia 4 with or without polydactyly 10.3 CASP3 TP53
10 bone ewing's sarcoma 10.3 ENO2 MYC MYCN
11 adrenal neuroblastoma 10.3 ENO2 MYCN
12 olfactory neuroblastoma 10.3 ENO2 NTRK1 NTRK2
13 rare adenocarcinoma of the breast 10.3 AKT1 TP53
14 childhood medulloblastoma 10.3 MYC MYCN TP53
15 causalgia 10.3 ENO2 NGF NTRK1
16 infratentorial cancer 10.3 MYC MYCN TP53
17 hereditary sensory neuropathy 10.3 NGF NTRK1 NTRK2
18 deafness, autosomal recessive 74 10.3 BACE1 CASP3
19 germ cell and embryonal cancer 10.3 ENO2 MYC TP53
20 pharynx squamous cell carcinoma 10.3 AKT1 CASP3
21 connective tissue cancer 10.3 AKT1 ENO2 TP53
22 ganglioneuroma 10.3 ENO2 MYCN NTRK1 NTRK2
23 supratentorial cancer 10.3 AKT1 CASP3 TP53
24 cerebrum cancer 10.3 AKT1 CASP3 TP53
25 cerebral primitive neuroectodermal tumor 10.3 ENO2 MYC MYCN TP53
26 medullomyoblastoma 10.3 ENO2 MYC MYCN TP53
27 rhabdomyosarcoma 10.3 ALK ENO2 MYCN TP53
28 nodular ganglioneuroblastoma 10.3 ALK ENO2 MYCN NTRK2
29 bladder disease 10.3 AKT1 NGF TP53
30 uterine anomalies 10.3 AKT1 CASP3 TP53
31 status epilepticus 10.3 CASP3 ENO2 NTRK2
32 neonatal hypoxic and ischemic brain injury 10.2 ENO2 TH
33 stomach disease 10.2 AKT1 CASP3 TP53
34 rhabdomyosarcoma 2 10.2 ALK ENO2 MYCN TH
35 differentiated thyroid carcinoma 10.2 ALK NTRK1 TP53
36 female reproductive system disease 10.2 AKT1 CASP3 TP53
37 nasopharyngeal disease 10.2 AKT1 CASP3 MYC TP53
38 pharynx cancer 10.2 AKT1 CASP3 MYC TP53
39 cervix disease 10.2 AKT1 CASP3 MYC TP53
40 leukocyte disease 10.2 AKT1 CASP3 MYC TP53
41 male reproductive organ cancer 10.2 AKT1 CASP3 MYC TP53
42 respiratory system disease 10.2 AKT1 ALK CASP3 TP53
43 male reproductive system disease 10.2 AKT1 CASP3 MYC TP53
44 ganglioneuroblastoma 10.2 ENO2 MYCN NTRK1 NTRK2 PHOX2B
45 reproductive system disease 10.2 AKT1 CASP3 MYC TP53
46 intestinal disease 10.2 AKT1 CASP3 MYC TP53
47 gastrointestinal system cancer 10.2 AKT1 CASP3 MYC TP53
48 ovarian disease 10.2 AKT1 CASP3 NGF TP53
49 endocrine gland cancer 10.2 AKT1 CASP3 MYC TP53
50 gastrointestinal system disease 10.2 AKT1 CASP3 MYC TP53

Graphical network of the top 20 diseases related to Autonomic Nervous System Neoplasm:



Diseases related to Autonomic Nervous System Neoplasm

Symptoms & Phenotypes for Autonomic Nervous System Neoplasm

MGI Mouse Phenotypes related to Autonomic Nervous System Neoplasm:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 AKT1 ALK BACE1 CASP3 CNTN6 ENO2
2 growth/size/body region MP:0005378 10.34 AKT1 ALK BACE1 CASP3 ENO2 MYC
3 nervous system MP:0003631 10.27 AKT1 ALK BACE1 CASP3 CNTN6 ENO2
4 cellular MP:0005384 10.25 AKT1 BACE1 CASP3 ENO2 MYC MYCN
5 mortality/aging MP:0010768 10.25 AKT1 ALK BACE1 CASP3 MYC MYCN
6 integument MP:0010771 10.11 AKT1 ALK BACE1 CASP3 MYC NGF
7 muscle MP:0005369 10.01 AKT1 BACE1 CASP3 MYC MYCN NGF
8 normal MP:0002873 10 AKT1 BACE1 MYC MYCN NGF NTRK1
9 hearing/vestibular/ear MP:0005377 9.95 CASP3 MYC NTRK1 NTRK2 NUMBL TP53
10 no phenotypic analysis MP:0003012 9.92 BACE1 CASP3 MYC MYCN NGF NTRK1
11 pigmentation MP:0001186 9.63 ALK CASP3 MFRP MYC NTRK1 TP53
12 respiratory system MP:0005388 9.61 AKT1 ALK CASP3 ENO2 MYCN NTRK2
13 vision/eye MP:0005391 9.32 ALK CASP3 MFRP MYCN NGF NTRK1

Drugs & Therapeutics for Autonomic Nervous System Neoplasm

Search Clinical Trials , NIH Clinical Center for Autonomic Nervous System Neoplasm

Genetic Tests for Autonomic Nervous System Neoplasm

Anatomical Context for Autonomic Nervous System Neoplasm

MalaCards organs/tissues related to Autonomic Nervous System Neoplasm:

41
Lung, Brain, Bone, Colon, Breast, Ovary, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Autonomic Nervous System Neoplasm:

19
The Autonomic Nervous System

Publications for Autonomic Nervous System Neoplasm

Variations for Autonomic Nervous System Neoplasm

Expression for Autonomic Nervous System Neoplasm

Search GEO for disease gene expression data for Autonomic Nervous System Neoplasm.

Pathways for Autonomic Nervous System Neoplasm

Pathways related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 AKT1 ALK CASP3 NGF NTRK1 NTRK2
2
Show member pathways
12.94 AKT1 CASP3 MYC NGF NTRK1 NTRK2
3
Show member pathways
12.8 AKT1 CASP3 MYC NTRK1 TP53
4 12.8 AKT1 ALK CASP3 MYC NTRK1 TP53
5
Show member pathways
12.77 AKT1 CASP3 MYC NGF NTRK1 TP53
6
Show member pathways
12.67 AKT1 CASP3 NGF NTRK1 NTRK2 TP53
7 12.58 AKT1 CASP3 MYC NGF NTRK1 NTRK2
8
Show member pathways
12.42 AKT1 CASP3 MYC TH
9
Show member pathways
12.4 AKT1 CASP3 NTRK1 NTRK2 TP53
10 12.4 BACE1 ENO2 MYCN NGF NTRK1 NTRK2
11 12.25 AKT1 CASP3 MYC TP53
12 12.25 AKT1 CASP3 MYC TP53
13 12.21 MYC MYCN NTRK1 TP53
14
Show member pathways
12.21 AKT1 MYC NGF NTRK1 NTRK2 TP53
15 12.15 AKT1 CASP3 MYC TP53
16 12.12 CASP3 NGF NTRK2 PHOX2B TH
17 12.1 AKT1 CASP3 MYC TP53
18 12.01 AKT1 CASP3 NGF NTRK1 NTRK2
19 11.89 AKT1 CASP3 MYC NTRK1 NTRK2 TP53
20 11.85 AKT1 CASP3 MYC TP53
21 11.69 AKT1 CASP3 TP53
22
Show member pathways
11.67 AKT1 CASP3 NGF TP53
23 11.65 AKT1 MYC NTRK1 TP53
24
Show member pathways
11.61 AKT1 CASP3 MYC NGF NTRK1 TP53
25
Show member pathways
11.6 NGF NTRK1 NTRK2
26 11.53 AKT1 BACE1 CASP3 TP53
27 11.45 BACE1 NTRK1 NTRK2
28 11.45 NGF NTRK1 NTRK2
29 11.44 AKT1 CASP3 MYC TP53
30 11.37 AKT1 CASP3 MYC TP53
31 11.37 AKT1 CNTN6 MYC MYCN TP53
32
Show member pathways
11.35 AKT1 CASP3 MFRP MYC NTRK1 NTRK2
33 11.28 AKT1 CASP3 NGF
34 10.81 CASP3 NTRK2
35
Show member pathways
10.69 NGF NTRK1 NTRK2
36 10.33 MYC MYCN

GO Terms for Autonomic Nervous System Neoplasm

Cellular components related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.55 BACE1 NGF NTRK1 NTRK2 TH
2 neuronal cell body GO:0043025 9.35 BACE1 CASP3 ENO2 NTRK1 TH
3 axon GO:0030424 9.1 BACE1 CNTN6 NGF NTRK1 NTRK2 TH

Biological processes related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.85 AKT1 ALK CNTN6 NTRK1 NTRK2 NUMBL
2 positive regulation of protein phosphorylation GO:0001934 9.84 AKT1 ALK NTRK1 NTRK2
3 protein autophosphorylation GO:0046777 9.83 AKT1 ALK NTRK1 NTRK2
4 cytokine-mediated signaling pathway GO:0019221 9.8 AKT1 CASP3 MYC NUMBL TP53
5 neuron differentiation GO:0030182 9.78 CASP3 CNTN6 NTRK2 PHOX2B
6 cellular response to organic cyclic compound GO:0071407 9.75 AKT1 CASP3 MYC
7 cellular response to drug GO:0035690 9.74 MYC TH TP53
8 cellular response to growth factor stimulus GO:0071363 9.72 AKT1 NTRK1 TH
9 response to nicotine GO:0035094 9.67 CASP3 NTRK1 TH
10 cellular response to nerve growth factor stimulus GO:1990090 9.63 AKT1 NTRK1 NTRK2
11 positive regulation of gene expression GO:0010628 9.63 AKT1 MYC MYCN NGF NTRK2 TP53
12 striated muscle cell differentiation GO:0051146 9.62 AKT1 CASP3
13 detection of mechanical stimulus involved in sensory perception of pain GO:0050966 9.61 BACE1 NTRK1
14 nerve growth factor signaling pathway GO:0038180 9.61 NGF NTRK1
15 positive regulation of mitochondrial membrane potential GO:0010918 9.6 AKT1 MYC
16 cellular response to manganese ion GO:0071287 9.59 BACE1 TH
17 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.58 MYCN TP53
18 cellular response to nicotine GO:0071316 9.56 NTRK1 TH
19 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.56 ALK NGF NTRK1 NTRK2
20 negative regulation of apoptotic process GO:0043066 9.56 AKT1 ALK CASP3 MYC NGF NTRK1
21 mechanoreceptor differentiation GO:0042490 9.51 NTRK1 NTRK2
22 response to gamma radiation GO:0010332 9.5 MYC TP53 TRIM13
23 neurotrophin signaling pathway GO:0038179 9.43 NTRK1 NTRK2
24 neurotrophin TRK receptor signaling pathway GO:0048011 8.92 CASP3 NGF NTRK1 NTRK2

Molecular functions related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.43 CASP3 CD177 TP53
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 ALK NTRK1 NTRK2
3 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
4 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Autonomic Nervous System Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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