MCID: ATN003
MIFTS: 34

Autonomic Nervous System Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Autonomic Nervous System Neoplasm

MalaCards integrated aliases for Autonomic Nervous System Neoplasm:

Name: Autonomic Nervous System Neoplasm 12 15 74
Tumor of Autonomic Nervous System 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2621
NCIt 51 C5112
UMLS 74 C1332356

Summaries for Autonomic Nervous System Neoplasm

Disease Ontology : 12 A peripheral nervous system neoplasm that is located in the autonomic nervous system.

MalaCards based summary : Autonomic Nervous System Neoplasm, also known as tumor of autonomic nervous system, is related to neuroblastoma and parameningeal embryonal rhabdomyosarcoma. An important gene associated with Autonomic Nervous System Neoplasm is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. Affiliated tissues include the autonomic nervous system, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Autonomic Nervous System Neoplasm

Diseases in the Autonomic Nervous System Neoplasm family:

Autonomic Nervous System Benign Neoplasm

Diseases related to Autonomic Nervous System Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 31.3 AKT1 ALK CASP3 ENO2 MYC MYCN
2 parameningeal embryonal rhabdomyosarcoma 10.5 ALK TP53
3 autonomic nervous system benign neoplasm 10.5 ENO2 MYCN NTRK1
4 prolactin producing pituitary tumor 10.5 NGF NTRK1 TP53
5 cerebral neuroblastoma 10.5 ENO2 NGF TP53
6 central nervous system benign neoplasm 10.5 ENO2 MYCN TP53
7 olfactory neuroblastoma 10.5 ENO2 NTRK1 NTRK2
8 bone ewing's sarcoma 10.5 ENO2 MYC MYCN
9 causalgia 10.5 ENO2 NGF NTRK1
10 meningeal melanomatosis 10.5 ENO2 NGF TP53
11 adult medulloblastoma 10.5 ENO2 MYCN TP53
12 brain injury 10.5 BDNF CASP3 ENO2
13 adrenal neuroblastoma 10.5 ENO2 MYCN
14 neuropathy, hereditary sensory and autonomic, type v 10.5 BDNF NGF NTRK1
15 neonatal hypoxic and ischemic brain injury 10.5 BDNF ENO2 TH
16 hereditary sensory neuropathy 10.5 NGF NTRK1 NTRK2
17 childhood medulloblastoma 10.5 MYC MYCN TP53
18 short-rib thoracic dysplasia 4 with or without polydactyly 10.4 CASP3 TP53
19 ganglioneuroma 10.4 ENO2 MYCN NTRK1 NTRK2
20 infratentorial cancer 10.4 MYC MYCN TP53
21 traumatic brain injury 10.4 BDNF CASP3 ENO2
22 germ cell and embryonal cancer 10.4 ENO2 MYC TP53
23 rare adenocarcinoma of the breast 10.4 AKT1 TP53
24 pharynx squamous cell carcinoma 10.4 AKT1 CASP3
25 connective tissue cancer 10.4 AKT1 ENO2 TP53
26 rhabdomyosarcoma 2 10.4 ALK ENO2 MYCN TH
27 cerebral primitive neuroectodermal tumor 10.4 ENO2 MYC MYCN TP53
28 medullomyoblastoma 10.4 ENO2 MYC MYCN TP53
29 rhabdomyosarcoma 10.4 ALK ENO2 MYCN TP53
30 supratentorial cancer 10.4 AKT1 CASP3 TP53
31 cerebrum cancer 10.4 AKT1 CASP3 TP53
32 uterine anomalies 10.4 AKT1 CASP3 TP53
33 insensitivity to pain, congenital, with anhidrosis 10.4 BDNF NTRK1
34 bladder disease 10.4 AKT1 NGF TP53
35 interstitial cystitis 10.4 BDNF KNG1 NGF
36 differentiated thyroid carcinoma 10.4 ALK NTRK1 TP53
37 stomach disease 10.4 AKT1 CASP3 TP53
38 ganglioneuroblastoma 10.4 ENO2 MYCN NTRK1 NTRK2 PHOX2B
39 status epilepticus 10.4 BDNF CASP3 ENO2 NTRK2
40 central hypoventilation syndrome, congenital 10.4 BDNF PHOX2B TH
41 nasopharyngeal disease 10.4 AKT1 CASP3 MYC TP53
42 pharynx cancer 10.4 AKT1 CASP3 MYC TP53
43 female reproductive system disease 10.4 AKT1 CASP3 TP53
44 cervix disease 10.4 AKT1 CASP3 MYC TP53
45 askin's tumor 10.4 ENO2 MYC MYCN NGF NTRK1
46 leukocyte disease 10.4 AKT1 CASP3 MYC TP53
47 male reproductive organ cancer 10.4 AKT1 CASP3 MYC TP53
48 respiratory system disease 10.4 AKT1 ALK CASP3 TP53
49 male reproductive system disease 10.4 AKT1 CASP3 MYC TP53
50 reproductive system disease 10.4 AKT1 CASP3 MYC TP53

Graphical network of the top 20 diseases related to Autonomic Nervous System Neoplasm:



Diseases related to Autonomic Nervous System Neoplasm

Symptoms & Phenotypes for Autonomic Nervous System Neoplasm

MGI Mouse Phenotypes related to Autonomic Nervous System Neoplasm:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.4 AKT1 ALK BDNF CASP3 CNTN6 ENO2
2 growth/size/body region MP:0005378 10.37 AKT1 ALK BDNF CASP3 ENO2 KNG1
3 nervous system MP:0003631 10.28 AKT1 ALK BDNF CASP3 CNTN6 ENO2
4 cellular MP:0005384 10.25 AKT1 BDNF CASP3 ENO2 MYC MYCN
5 mortality/aging MP:0010768 10.25 AKT1 ALK BDNF CASP3 MYC MYCN
6 integument MP:0010771 10.11 AKT1 ALK BDNF CASP3 MYC NGF
7 normal MP:0002873 10.06 AKT1 BDNF MYC MYCN NGF NTRK1
8 hearing/vestibular/ear MP:0005377 10.02 BDNF CASP3 MYC NTRK1 NTRK2 NUMBL
9 no phenotypic analysis MP:0003012 9.97 BDNF CASP3 MYC MYCN NGF NTRK1
10 reproductive system MP:0005389 9.81 AKT1 ALK BDNF CASP3 MYC MYCN
11 pigmentation MP:0001186 9.65 ALK CASP3 MYC NTRK1 TP53
12 respiratory system MP:0005388 9.65 AKT1 ALK BDNF CASP3 ENO2 MYCN
13 vision/eye MP:0005391 9.32 ALK BDNF CASP3 MYCN NGF NTRK1

Drugs & Therapeutics for Autonomic Nervous System Neoplasm

Search Clinical Trials , NIH Clinical Center for Autonomic Nervous System Neoplasm

Genetic Tests for Autonomic Nervous System Neoplasm

Anatomical Context for Autonomic Nervous System Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Autonomic Nervous System Neoplasm:

20
The Autonomic Nervous System

Publications for Autonomic Nervous System Neoplasm

Variations for Autonomic Nervous System Neoplasm

Expression for Autonomic Nervous System Neoplasm

Search GEO for disease gene expression data for Autonomic Nervous System Neoplasm.

Pathways for Autonomic Nervous System Neoplasm

Pathways related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 AKT1 ALK BDNF CASP3 MYC NGF
2
Show member pathways
13.53 AKT1 ALK BDNF MYC NGF NTRK1
3
Show member pathways
13.39 AKT1 ALK BDNF CASP3 NGF NTRK1
4
Show member pathways
13.26 AKT1 ALK BDNF CASP3 NGF NTRK1
5
Show member pathways
13.05 AKT1 BDNF NGF NTRK1 NTRK2 TP53
6
Show member pathways
13.04 AKT1 ALK BDNF NGF NTRK1 NTRK2
7
Show member pathways
12.91 AKT1 BDNF CASP3 MYC NGF NTRK1
8
Show member pathways
12.84 AKT1 CASP3 MYC NTRK1 TP53
9 12.83 AKT1 ALK CASP3 MYC NTRK1 TP53
10
Show member pathways
12.78 AKT1 CASP3 MYC NGF NTRK1 TP53
11
Show member pathways
12.72 AKT1 BDNF NGF NTRK1 NTRK2
12
Show member pathways
12.63 AKT1 BDNF CASP3 NGF NTRK1 NTRK2
13
Show member pathways
12.62 AKT1 BDNF NGF NTRK1 NTRK2
14 12.58 ENO2 MYCN NGF NTRK1 NTRK2 TH
15
Show member pathways
12.45 AKT1 CASP3 MYC TH
16
Show member pathways
12.42 AKT1 CASP3 NTRK1 NTRK2 TP53
17
Show member pathways
12.38 ALK BDNF NGF NTRK1 NTRK2
18 12.27 AKT1 CASP3 MYC TP53
19 12.23 MYC MYCN NTRK1 TP53
20 12.23 AKT1 BDNF CASP3 MYC NGF NTRK1
21
Show member pathways
12.19 AKT1 BDNF MYC NGF NTRK1 NTRK2
22 12.17 AKT1 CASP3 MYC TP53
23
Show member pathways
12.16 AKT1 CASP3 MYC NTRK1 NTRK2 TP53
24 12.13 AKT1 CASP3 MYC TP53
25 12.06 BDNF CASP3 NGF NTRK2 PHOX2B TH
26 12.04 AKT1 CASP3 MYC NTRK1 NTRK2 TP53
27 12 BDNF CASP3 MYC TP53
28 11.98 BDNF NGF NTRK1 NTRK2
29 11.86 AKT1 CASP3 MYC TP53
30
Show member pathways
11.81 AKT1 CASP3 MYC NGF NTRK1 TP53
31 11.77 BDNF NGF TH
32 11.72 AKT1 CASP3 TP53
33 11.7 AKT1 MYC NTRK1 TP53
34
Show member pathways
11.64 BDNF NGF NTRK1 NTRK2
35 11.56 AKT1 CASP3 TP53
36 11.54 AKT1 CASP3 MYC TP53
37
Show member pathways
11.54 AKT1 BDNF CASP3 NGF TP53
38 11.49 AKT1 CASP3 MYC TP53
39 11.47 AKT1 CNTN6 MYC MYCN TP53
40 11.46 BDNF NGF NTRK1 NTRK2
41 11.34 AKT1 BDNF NTRK2
42 11.3 AKT1 CASP3 NGF
43 11.26 AKT1 BDNF CASP3 NGF NTRK1 NTRK2
44 11 ALK BDNF NGF NTRK1 NTRK2
45 10.9 BDNF CASP3 NTRK2
46
Show member pathways
10.77 NGF NTRK1 NTRK2
47 10.35 MYC MYCN

GO Terms for Autonomic Nervous System Neoplasm

Cellular components related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.93 AKT1 BDNF CASP3 ENO2 NTRK1 NTRK2
2 dendrite GO:0030425 9.35 BDNF NGF NTRK1 NTRK2 TH
3 axon GO:0030424 9.1 BDNF CNTN6 NGF NTRK1 NTRK2 TH

Biological processes related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.95 AKT1 CASP3 KNG1 NGF TP53
2 protein autophosphorylation GO:0046777 9.87 AKT1 ALK NTRK1 NTRK2
3 positive regulation of gene expression GO:0010628 9.85 AKT1 MYC MYCN NGF NTRK2 TP53
4 cytokine-mediated signaling pathway GO:0019221 9.83 AKT1 CASP3 MYC NUMBL TP53
5 memory GO:0007613 9.81 BDNF NGF TH
6 negative regulation of neuron apoptotic process GO:0043524 9.81 BDNF NGF NTRK1 NTRK2
7 neuron differentiation GO:0030182 9.8 CASP3 CNTN6 NTRK2 PHOX2B
8 nervous system development GO:0007399 9.8 AKT1 ALK BDNF CNTN6 NTRK1 NTRK2
9 cellular response to drug GO:0035690 9.79 MYC TH TP53
10 positive regulation of synapse assembly GO:0051965 9.77 BDNF NTRK1 NTRK2
11 cellular response to growth factor stimulus GO:0071363 9.76 AKT1 NTRK1 TH
12 positive regulation of protein phosphorylation GO:0001934 9.75 AKT1 NTRK1 NTRK2
13 response to nicotine GO:0035094 9.7 CASP3 NTRK1 TH
14 striated muscle cell differentiation GO:0051146 9.65 AKT1 CASP3
15 cellular response to nerve growth factor stimulus GO:1990090 9.65 AKT1 NTRK1 NTRK2
16 nerve development GO:0021675 9.64 BDNF NGF
17 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.63 MYCN TP53
18 cellular response to organic cyclic compound GO:0071407 9.62 AKT1 CASP3
19 cellular response to nicotine GO:0071316 9.61 NTRK1 TH
20 positive regulation of collateral sprouting GO:0048672 9.61 BDNF NGF
21 positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997 9.59 BDNF NTRK2
22 response to gamma radiation GO:0010332 9.58 MYC TP53 TRIM13
23 mechanoreceptor differentiation GO:0042490 9.56 NTRK1 NTRK2
24 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.55 ALK BDNF NGF NTRK1 NTRK2
25 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 9.54 BDNF NTRK2
26 nerve growth factor signaling pathway GO:0038180 9.5 BDNF NGF NTRK1
27 neurotrophin signaling pathway GO:0038179 9.46 NTRK1 NTRK2
28 negative regulation of apoptotic process GO:0043066 9.43 AKT1 CASP3 MYC NGF NTRK1 TP53
29 positive regulation of mitochondrial membrane potential GO:0010918 9.34 AKT1
30 neurotrophin TRK receptor signaling pathway GO:0048011 9.02 BDNF CASP3 NGF NTRK1 NTRK2

Molecular functions related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.43 CASP3 CD177 TP53
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.33 ALK NTRK1 NTRK2
3 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
4 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2

Sources for Autonomic Nervous System Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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