MCID: ATN003
MIFTS: 33

Autonomic Nervous System Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Autonomic Nervous System Neoplasm

MalaCards integrated aliases for Autonomic Nervous System Neoplasm:

Name: Autonomic Nervous System Neoplasm 12 15 73
Tumor of Autonomic Nervous System 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2621
NCIt 50 C5112
UMLS 73 C1332356

Summaries for Autonomic Nervous System Neoplasm

Disease Ontology : 12 A peripheral nervous system neoplasm that is located in the autonomic nervous system.

MalaCards based summary : Autonomic Nervous System Neoplasm, also known as tumor of autonomic nervous system, is related to neuroblastoma and parameningeal embryonal rhabdomyosarcoma. An important gene associated with Autonomic Nervous System Neoplasm is MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Akt Signaling and PI3K-Akt signaling pathway. Affiliated tissues include the autonomic nervous system, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Autonomic Nervous System Neoplasm

Diseases related to Autonomic Nervous System Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 29.6 AKT1 ALK BACE1 CASP3 ENO2 MYC
2 parameningeal embryonal rhabdomyosarcoma 11.1 ALK TP53
3 neuropathy, hereditary sensory and autonomic, type v 11.0 NGF NTRK1
4 rare adenocarcinoma of the breast 11.0 AKT1 TP53
5 cervical neuroblastoma 11.0 MYCN VIP
6 extracranial neuroblastoma 11.0 MYCN VIP
7 prolactin producing pituitary tumor 11.0 NGF NTRK1 TP53
8 adult medulloblastoma 11.0 ENO2 MYCN TP53
9 cerebral neuroblastoma 11.0 ENO2 NGF TP53
10 meningeal melanomatosis 10.9 ENO2 NGF TP53
11 bone ewing's sarcoma 10.9 ENO2 MYC MYCN
12 traumatic brain injury 10.9 CASP3 ENO2 NGF
13 adrenal neuroblastoma 10.9 ENO2 MYCN
14 infratentorial cancer 10.9 MYC MYCN TP53
15 short-rib thoracic dysplasia 4 with or without polydactyly 10.9 CASP3 TP53
16 connective tissue cancer 10.9 AKT1 ENO2 TP53
17 hereditary sensory neuropathy 10.9 NGF NTRK1 NTRK2
18 pharynx cancer 10.9 AKT1 CASP3 TP53
19 integumentary system cancer 10.8 AKT1 ENO2 TP53
20 primary effusion lymphoma 10.8 AKT1 CASP3 MYC
21 peripheral nervous system disease 10.8 MFRP NGF PHOX2B
22 deafness, autosomal recessive 74 10.8 BACE1 CASP3
23 megaesophagus 10.8 MYC TP53 VIP
24 achalasia 10.8 ENO2 TP53 VIP
25 cerebral primitive neuroectodermal tumor 10.8 ENO2 MYC MYCN TP53
26 nodular ganglioneuroblastoma 10.8 ALK ENO2 MYCN NTRK2
27 medullomyoblastoma 10.8 ENO2 MYC MYCN TP53
28 rhabdomyosarcoma 2 10.8 ALK ENO2 MYCN TH
29 differentiated thyroid carcinoma 10.7 ALK NTRK1 TP53
30 status epilepticus 10.7 CASP3 ENO2 NTRK2
31 neonatal hypoxic and ischemic brain injury 10.7 ENO2 TH
32 central nervous system disease 10.7 BACE1 CASP3 NGF TH
33 male reproductive organ cancer 10.7 AKT1 CASP3 MYC TP53
34 female reproductive organ cancer 10.7 AKT1 CASP3 MYC TP53
35 gastrointestinal system cancer 10.7 AKT1 CASP3 MYC TP53
36 endocrine gland cancer 10.7 AKT1 ENO2 TP53 VIP
37 rhabdomyosarcoma 10.7 ALK ENO2 MYCN TP53
38 lung papillary adenocarcinoma 10.7 ALK TP53
39 askin's tumor 10.7 ENO2 MYC MYCN NGF NTRK1
40 mantle cell lymphoma 10.7 AKT1 CASP3 MYC TP53
41 tongue squamous cell carcinoma 10.6 AKT1 CASP3 TP53
42 atypical follicular adenoma 10.6 ENO2 TP53
43 myeloma, multiple 10.6 AKT1 CASP3 MYC TP53
44 nervous system disease 10.6 BACE1 CASP3 MFRP NGF TH
45 ganglioneuroma 10.6 ENO2 MYCN NTRK1 NTRK2 VIP
46 sudden infant death syndrome 10.6 CASP3 NTRK2 PHOX2B TH
47 toxic encephalopathy 10.6 AKT1 BACE1 CASP3 NGF TH
48 lymphoma, non-hodgkin, familial 10.5 ALK CASP3 MYC TP53
49 hematologic cancer 10.5 ALK CASP3 MYC TP53
50 pheochromocytoma 10.5 ENO2 NGF NTRK1 TH VIP

Graphical network of the top 20 diseases related to Autonomic Nervous System Neoplasm:



Diseases related to Autonomic Nervous System Neoplasm

Symptoms & Phenotypes for Autonomic Nervous System Neoplasm

MGI Mouse Phenotypes related to Autonomic Nervous System Neoplasm:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.45 CNTN6 ENO2 BACE1 MYC AKT1 CASP3
2 growth/size/body region MP:0005378 10.37 ENO2 BACE1 AKT1 CASP3 ALK MYCN
3 nervous system MP:0003631 10.31 CNTN6 ENO2 BACE1 MFRP AKT1 CASP3
4 mortality/aging MP:0010768 10.3 ALK BACE1 AKT1 CASP3 MYCN NTRK2
5 cellular MP:0005384 10.28 ENO2 BACE1 AKT1 CASP3 MYCN NTRK2
6 homeostasis/metabolism MP:0005376 10.27 CASP3 ALK BACE1 AKT1 MYCN NTRK2
7 integument MP:0010771 10.13 ALK BACE1 AKT1 CASP3 NGF MYC
8 normal MP:0002873 10.1 BACE1 AKT1 NTRK2 NGF MYC NTRK1
9 muscle MP:0005369 10.03 BACE1 AKT1 CASP3 MYCN NGF MYC
10 hearing/vestibular/ear MP:0005377 9.99 CASP3 NTRK1 NTRK2 MYC NUMBL TP53
11 no phenotypic analysis MP:0003012 9.97 BACE1 CASP3 MYCN NGF MYC NTRK1
12 reproductive system MP:0005389 9.81 ALK AKT1 CASP3 MYCN NTRK2 MYC
13 pigmentation MP:0001186 9.73 ALK MFRP CASP3 MYC NTRK1 TP53
14 respiratory system MP:0005388 9.65 ENO2 AKT1 CASP3 ALK NTRK2 MYCN
15 vision/eye MP:0005391 9.32 MFRP CASP3 ALK MYCN NTRK2 NGF

Drugs & Therapeutics for Autonomic Nervous System Neoplasm

Search Clinical Trials , NIH Clinical Center for Autonomic Nervous System Neoplasm

Genetic Tests for Autonomic Nervous System Neoplasm

Anatomical Context for Autonomic Nervous System Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Autonomic Nervous System Neoplasm:

19
The Autonomic Nervous System

Publications for Autonomic Nervous System Neoplasm

Variations for Autonomic Nervous System Neoplasm

Expression for Autonomic Nervous System Neoplasm

Search GEO for disease gene expression data for Autonomic Nervous System Neoplasm.

Pathways for Autonomic Nervous System Neoplasm

Pathways related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 AKT1 ALK CASP3 NGF NTRK1 NTRK2
2
Show member pathways
12.92 AKT1 CASP3 MYC NGF NTRK1 NTRK2
3
Show member pathways
12.8 AKT1 CASP3 MYC NTRK1 TP53
4 12.8 AKT1 ALK CASP3 MYC NTRK1 TP53
5
Show member pathways
12.76 AKT1 CASP3 MYC NGF NTRK1 TP53
6
Show member pathways
12.67 AKT1 CASP3 NGF NTRK1 NTRK2 TP53
7 12.53 AKT1 CASP3 MYC NGF NTRK1 NTRK2
8
Show member pathways
12.41 AKT1 CASP3 MYC TH
9
Show member pathways
12.4 AKT1 CASP3 NTRK1 NTRK2 TP53
10 12.24 AKT1 CASP3 MYC TP53
11 12.2 MYC MYCN NTRK1 TP53
12 12.14 AKT1 CASP3 MYC TP53
13 12.1 CASP3 NGF NTRK2 PHOX2B TH
14 12.09 AKT1 CASP3 MYC TP53
15
Show member pathways
12.02 MFRP MYC NTRK1 NTRK2
16 11.99 AKT1 CASP3 NGF NTRK1 NTRK2
17 11.89 AKT1 CASP3 MYC NTRK1 NTRK2 TP53
18 11.84 AKT1 CASP3 MYC TP53
19
Show member pathways
11.76 AKT1 MYC VIP
20 11.76 BACE1 ENO2 MYCN NGF NTRK1 NTRK2
21 11.68 AKT1 CASP3 TP53
22
Show member pathways
11.64 AKT1 CASP3 NGF TP53
23 11.62 AKT1 MYC NTRK1 TP53
24
Show member pathways
11.61 AKT1 CASP3 MYC NGF NTRK1 TP53
25
Show member pathways
11.59 NGF NTRK1 NTRK2
26 11.51 AKT1 BACE1 CASP3 TP53
27 11.44 BACE1 NTRK1 NTRK2
28 11.41 AKT1 CASP3 MYC TP53
29 11.37 AKT1 CNTN6 MYC MYCN TP53
30 11.33 AKT1 CASP3 MYC TP53
31 11.27 AKT1 CASP3 NGF
32 10.8 CASP3 NTRK2
33
Show member pathways
10.67 NGF NTRK1 NTRK2
34 10.32 MYC MYCN

GO Terms for Autonomic Nervous System Neoplasm

Cellular components related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.35 AKT1 ALK MYC NTRK1 TP53
2 axon GO:0030424 9.02 BACE1 NGF NTRK1 NTRK2 TH

Biological processes related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.88 AKT1 CASP3 MYC NUMBL TP53
2 nervous system development GO:0007399 9.85 AKT1 ALK CNTN6 NTRK1 NTRK2 NUMBL
3 protein autophosphorylation GO:0046777 9.83 AKT1 ALK NTRK1 NTRK2
4 response to estradiol GO:0032355 9.79 CASP3 MYC TH
5 cellular response to organic cyclic compound GO:0071407 9.76 AKT1 CASP3 MYC
6 neuron differentiation GO:0030182 9.76 CASP3 CNTN6 NTRK2 PHOX2B
7 positive regulation of kinase activity GO:0033674 9.75 ALK NTRK1 NTRK2
8 cellular response to drug GO:0035690 9.73 MYC TH TP53
9 cellular response to growth factor stimulus GO:0071363 9.71 AKT1 NTRK1 TH
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 ALK NGF NTRK1 NTRK2
11 response to nicotine GO:0035094 9.67 CASP3 NTRK1 TH
12 positive regulation of gene expression GO:0010628 9.63 AKT1 MYC MYCN NGF NTRK2 TP53
13 cellular response to nerve growth factor stimulus GO:1990090 9.61 AKT1 NTRK1 NTRK2
14 nerve growth factor signaling pathway GO:0038180 9.6 NGF NTRK1
15 positive regulation of mitochondrial membrane potential GO:0010918 9.57 AKT1 MYC
16 cellular response to nicotine GO:0071316 9.55 NTRK1 TH
17 mechanoreceptor differentiation GO:0042490 9.51 NTRK1 NTRK2
18 response to gamma radiation GO:0010332 9.43 MYC TP53 TRIM13
19 neurotrophin signaling pathway GO:0038179 9.32 NTRK1 NTRK2
20 negative regulation of apoptotic process GO:0043066 9.23 AKT1 ALK CASP3 MYC NGF NTRK1
21 neurotrophin TRK receptor signaling pathway GO:0048011 9.13 CASP3 NGF NTRK1
22 multicellular organism development GO:0007275 10.14 AKT1 ALK NTRK1 NTRK2 NUMBL PHOX2B
23 positive regulation of cell proliferation GO:0008284 10 AKT1 MYC MYCN NTRK2 VIP

Molecular functions related to Autonomic Nervous System Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 9.54 ALK NTRK1 NTRK2
2 mitogen-activated protein kinase kinase binding GO:0031434 9.5 ALK NTRK1 NTRK2
3 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 ALK NTRK1 NTRK2
4 neurotrophin binding GO:0043121 8.96 NTRK1 NTRK2
5 neurotrophin receptor activity GO:0005030 8.62 NTRK1 NTRK2
6 protein binding GO:0005515 10.11 AKT1 ALK BACE1 CASP3 CD177 CNTN6

Sources for Autonomic Nervous System Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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