MCID: ATN004
MIFTS: 46

Autonomic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Autonomic Neuropathy

MalaCards integrated aliases for Autonomic Neuropathy:

Name: Autonomic Neuropathy 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11504
NCIt 50 C27033
SNOMED-CT 68 277879009
UMLS 73 C0259749

Summaries for Autonomic Neuropathy

MalaCards based summary : Autonomic Neuropathy is related to hereditary sensory and autonomic neuropathy type 1 and neuropathy, hereditary sensory and autonomic, type v. An important gene associated with Autonomic Neuropathy is RETREG1 (Reticulophagy Regulator 1), and among its related pathways/superpathways are Neuroscience and Activation of TRKA receptors. The drugs Quinapril and Midodrine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Autonomic neuropathy (also AN or AAN) is a form of polyneuropathy that affects the non-voluntary,... more...

Related Diseases for Autonomic Neuropathy

Diseases related to Autonomic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 hereditary sensory and autonomic neuropathy type 1 34.5 SPTLC1 SPTLC2
2 neuropathy, hereditary sensory and autonomic, type v 33.9 NGF NTRK1
3 neuropathy, hereditary sensory and autonomic, type iii 33.8 ELP1 NGF
4 neuropathy, hereditary sensory, type ie 33.5 SPTLC1 SPTLC2
5 diabetic autonomic neuropathy 32.9 AKR1B1 INS NGF
6 neuropathy, hereditary sensory and autonomic, type iia 32.9 ELP1 KIF1A RETREG1 SCN9A WNK1
7 autonomic dysfunction 31.8 RETREG1 SCN9A SPTLC1 WNK1
8 autonomic nervous system disease 30.8 ALB INS NGF
9 hereditary sensory neuropathy 30.7 ELP1 KIF1A NGF NTRK1 RETREG1 SPTLC1
10 anhidrosis 30.2 NGF NTRK1
11 diabetic neuropathy 30.2 AKR1B1 INS NGF NTRK1 SCN9A
12 diabetic polyneuropathy 30.0 AKR1B1 NGF
13 peripheral nervous system disease 29.4 ELP1 INS NGF SCN9A
14 microvascular complications of diabetes 5 28.9 AKR1B1 ALB INS
15 microvascular complications of diabetes 3 28.8 AKR1B1 ALB INS
16 neuropathy 28.7 DST ELP1 KIF1A NGF RETREG1 SCN9A
17 pheochromocytoma 28.3 NGF NPY NTRK1
18 idiopathic peripheral autonomic neuropathy 12.1
19 insensitivity to pain, congenital, with anhidrosis 12.1
20 neuropathy, hereditary sensory and autonomic, type vii 12.1
21 neuropathy, hereditary sensory and autonomic, type viii 12.0
22 x-linked hereditary sensory and autonomic neuropathy with deafness 12.0
23 hereditary sensory and autonomic neuropathy with deafness and global delay 12.0
24 neuropathy, hereditary sensory and autonomic, type ic 11.9
25 neuropathy, hereditary sensory and autonomic, type iib 11.8
26 neuropathy, hereditary sensory and autonomic, type ia 11.8
27 neuropathy, hereditary sensory and autonomic, type vi 11.8
28 neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux 11.7
29 sensory peripheral neuropathy 11.4
30 autoimmune autonomic ganglionopathy 11.3
31 dysautonomia 11.2
32 lipomatosis, multiple symmetric 11.2
33 neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive 11.0
34 deafness, x-linked 5 11.0
35 dnmt1-related dementia, deafness, and sensory neuropathy 11.0
36 prp systemic amyloidosis 11.0
37 indifference to pain, congenital, autosomal recessive 10.9
38 neuropathy, hereditary sensory, type id 10.9
39 neuropathy, hereditary sensory, type iic 10.9
40 neuropathy, hereditary sensory, type if 10.9
41 autoimmune gastrointestinal dysmotility 10.9
42 ramos arroyo clark syndrome 10.9
43 hereditary neuropathies 10.9
44 familial syringomyelia 10.9
45 diabetes mellitus 10.6
46 burning mouth syndrome 10.5 NGF SCN9A
47 askin's tumor 10.5 NGF NTRK1
48 prolactin producing pituitary tumor 10.5 NGF NTRK1
49 conjunctival nevus 10.5 NGF NTRK1
50 jejunoileitis 10.4 ELP1 NGF

Graphical network of the top 20 diseases related to Autonomic Neuropathy:



Diseases related to Autonomic Neuropathy

Symptoms & Phenotypes for Autonomic Neuropathy

MGI Mouse Phenotypes related to Autonomic Neuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 AKR1B1 ELP1 INS KIF1A NGF NPY
2 growth/size/body region MP:0005378 10.07 AKR1B1 ELP1 INS KIF1A NGF NPY
3 mortality/aging MP:0010768 10 KIF1A NGF NTRK1 SCN9A SPTLC1 SPTLC2
4 integument MP:0010771 9.92 ELP1 INS KIF1A NGF NTRK1 RETREG1
5 nervous system MP:0003631 9.65 INS KIF1A NGF NPY NTRK1 RETREG1
6 muscle MP:0005369 9.63 ALB ELP1 INS NGF NTRK1 WNK1
7 renal/urinary system MP:0005367 9.17 AKR1B1 ALB ELP1 INS NPY SCN9A

Drugs & Therapeutics for Autonomic Neuropathy

Drugs for Autonomic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 160)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
2
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
3
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
4
Droxidopa Approved, Investigational Phase 4,Phase 3,Phase 2 23651-95-8 443940
5
Vildagliptin Approved, Investigational Phase 4,Phase 2 274901-16-5 6918537
6
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
7
Donepezil Approved Phase 4,Not Applicable 120014-06-4 3152
8
Norepinephrine Approved Phase 4,Phase 2,Not Applicable 51-41-2 439260
9
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
10
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
12 Adjuvants, Immunologic Phase 4
13 Benphothiamine Phase 4
14 Chelating Agents Phase 4
15 HIV Protease Inhibitors Phase 4,Phase 2
16
protease inhibitors Phase 4,Phase 2
17 Hormone Antagonists Phase 4,Phase 2,Not Applicable
18 Hormones Phase 4,Phase 2,Not Applicable
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
20 Dipeptidyl-Peptidase IV Inhibitors Phase 4,Phase 2
21 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Antioxidants Phase 4,Phase 3,Phase 1
23 Micronutrients Phase 4,Phase 3
24 Protective Agents Phase 4,Phase 3,Phase 1
25 Thioctic Acid Phase 4
26 Trace Elements Phase 4,Phase 3
27 Vitamin B Complex Phase 4,Phase 3,Not Applicable
28 Vitamins Phase 4,Phase 3,Not Applicable
29 Angiotensin-Converting Enzyme Inhibitors Phase 4
30 Antihypertensive Agents Phase 4,Not Applicable
31 Adrenergic Agents Phase 4,Phase 3,Phase 2
32 Adrenergic Agonists Phase 4,Phase 3,Phase 2
33 Adrenergic alpha-Agonists Phase 4,Phase 2
34 Autonomic Agents Phase 4,Phase 3,Phase 2
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Vasoconstrictor Agents Phase 4,Phase 2
38 Antiparkinson Agents Phase 4,Phase 3,Phase 2
39 Dopamine Agents Phase 4,Phase 3,Phase 2
40 Analgesics Phase 4,Phase 2,Phase 3
41 Anti-Anxiety Agents Phase 4,Phase 2
42 Anticonvulsants Phase 4,Phase 3,Phase 2
43 Antidepressive Agents Phase 4,Phase 3
44 calcium channel blockers Phase 4,Phase 2
45 Calcium, Dietary Phase 4,Phase 2,Not Applicable
46 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
47 Cholinergic Agents Phase 4,Phase 3,Not Applicable,Early Phase 1
48 Cholinesterase Inhibitors Phase 4,Not Applicable,Early Phase 1
49 Excitatory Amino Acid Antagonists Phase 4,Phase 3
50 Excitatory Amino Acids Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 104)
# Name Status NCT ID Phase Drugs
1 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
2 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
3 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy Completed NCT02056366 Phase 4 α-lipoic acid
4 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
5 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
6 Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects Recruiting NCT02682901 Phase 4 Cycloset;Placebo
7 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
8 Effects of DPP4 Inhibitor Versus SGLT2 Inhibitor Recruiting NCT03178591 Phase 4 vildagliptin;Dapagliflozin
9 Effect of Liraglutide on Vascular Inflammation in Type-2 Diabetes Recruiting NCT03449654 Phase 4 Liraglutide;Placebo (for liraglutide)
10 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4 midodrine hydrochloride (ProAmatine®)
11 Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Terminated NCT00619983 Phase 4 donepezil;duloxetine;donepezil 2.5 mg and duloxetine 30mg;placebo;gabapentin
12 Pioglitazone in Impaired Glucose Tolerance Withdrawn NCT00306826 Phase 4 pioglitazone;simvastatin;pioglitazone + simvastatin
13 Fluid Retention in Rosiglitazone Treated Subjects With Autonomic Neuropathy. Completed NCT00422955 Phase 3 rosiglitazone
14 An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes Completed NCT00116207 Phase 3 ORAL ANTIOXIDANT
15 Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT) Completed NCT00594152 Phase 3 CIIIT
16 Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia Completed NCT01212484 Phase 3 Carbidopa;Placebo
17 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3 Droxidopa;Placebo
18 Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Completed NCT01522235 Phase 2, Phase 3 Double blinded IVIg
19 The Effect of Diflunisal on Familial Amyloidosis Completed NCT00294671 Phase 2, Phase 3 diflunisal
20 Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed NCT00516503 Phase 3 baclofen/amitriptyline/ketamine gel
21 An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid Polyneuropathy Completed NCT00791492 Phase 2, Phase 3 Fx-1006A
22 Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis Completed NCT00409175 Phase 2, Phase 3 Fx-1006A;Placebo
23 The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia Completed NCT01987219 Phase 3 Albuterol-sulphate;Ipratropium-bromide
24 Effect of Autonomic Neuropathy on the Efficacy of a DPP-IV Inhibitor (Galvus) Therapy Completed NCT01452113 Phase 2 Vildagliptin
25 L-Serine Supplementation in Hereditary Sensory Neuropathy Type 1 Completed NCT01733407 Phase 1, Phase 2 L-serine;placebo
26 Bortezomib, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00742625 Phase 1, Phase 2 daunorubicin hydrochloride;cytarabine;bortezomib
27 Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy Completed NCT00760955 Phase 2 TAK-583;TAK-583;TAK-583;Placebo
28 A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain Completed NCT01345045 Phase 2 ABT-639;pregabalin;Placebo
29 The Effects of Fx-1006A on Transthyretin Stabilization and Clinical Outcome Measures in Patients With Non-V30M Transthyretin Amyloidosis Completed NCT00630864 Phase 2 Fx-1006A
30 Carbidopa for the Treatment of Excessive Blood Pressure Variability Recruiting NCT02553265 Phase 2 Carbidopa Low Dose;Carbidopa High Dose
31 The Safety, Tolerability and Efficacy of Dronabinol, for the Treatment of Nausea and Vomiting in Familial Dysautonomia Recruiting NCT02608931 Phase 2 Dronabinol
32 The Safety and Tolerability of Kinetin, in Patients With Familial Dysautonomia Recruiting NCT02274051 Phase 2
33 The Efficacy Of Intravenous Immunoglobulin Therapy In Treatment Induced Neuropathy Of Diabetes Recruiting NCT02915263 Phase 2 IGIV-C;0.9% Sodium Chloride
34 Evaluation of Diagnostic Methods and Dietary Treatment of Diabetic Gastroparesis Recruiting NCT01557296 Phase 2
35 The Nutritional Supplement Phosphatidylserine in Patients With Familial Dysautonomia Recruiting NCT02276716 Phase 2 Phosphatidylserine
36 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2 Droxidopa (L-DOPS);Placebo
37 Cardiac Autonomic Neuropathy in Patients With Metabolic Syndrome Completed NCT00907127 Phase 1
38 N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer Withdrawn NCT01138137 Phase 1 Paclitaxel;N-acetylcysteine;Cisplatin
39 The Relationship Between Vascular Adhesion Protein-1 and Diabetic Cardiovascular Autonomic Neuropathy Unknown status NCT01706289
40 A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes Unknown status NCT01822431
41 Effect of DPP-IV Inhibitor on Glycemic Control and Autonomic Neuropathy in Adult Patients With Diabetes Mellitus Unknown status NCT01545024 Sitagliptin, 50 mg once per day per os
42 Sleep Apnea in Type 1 Diabetes Unknown status NCT01935765 Early Phase 1
43 Acute Effects of Inspiratory Muscle Exercise on Glucose Level and Glucose Variability in Patients With Type 2 Diabetes. Unknown status NCT02292810 Not Applicable
44 Functional Electrical Stimulation in Chronic Kidney Disease Unknown status NCT02336776 Not Applicable
45 Effects of Feet Mechanical Stimulation on Cardiovascular Autonomic Profile and Inflammation in Parkinson's Disease Unknown status NCT02608424 Not Applicable
46 Small-fiber Neuropathy in Chronic Kidney Disease Unknown status NCT01078857 Not Applicable
47 Risk Analysis for Cardiovascular Autonomic Neuropathy Completed NCT02462616
48 Genetic, Environment and Its Interaction Analysis for Cardiovascular Autonomic Neuropathy Completed NCT02461342
49 Bayesian Estimation of Diagnostic Performance for Cardiovascular Autonomic Neuropathy Completed NCT02459522
50 QUANtification of Cardiovascular Autonomic Neuropathy (CAN) and the Effects of Anaesthesia on Haemodynamics and Cerebral Perfusion Completed NCT03071432 Not Applicable

Search NIH Clinical Center for Autonomic Neuropathy

Genetic Tests for Autonomic Neuropathy

Anatomical Context for Autonomic Neuropathy

MalaCards organs/tissues related to Autonomic Neuropathy:

41
Heart, Testes, Kidney, Spinal Cord, Brain, Skin, Endothelial

Publications for Autonomic Neuropathy

Articles related to Autonomic Neuropathy:

(show top 50) (show all 931)
# Title Authors Year
1
Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association? ( 29725320 )
2018
2
Repeated hyperhidrosis and chilblain-like swelling with ulceration of the fingers and toes in hereditary sensory and autonomic neuropathy type II. ( 29701257 )
2018
3
Toenail changes in autonomic neuropathy. ( 29923035 )
2018
4
Serum apolipoprotein A-1 concentrations and the prevalence of cardiovascular autonomic neuropathy in individuals with type 2 diabetes. ( 29453140 )
2018
5
Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients. ( 29693021 )
2018
6
Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment. ( 29359025 )
2018
7
The prognostic value of the frontal QRS-T angle is comparable to cardiovascular autonomic neuropathy regarding long-term mortality in people with diabetes. A population based study. ( 29775674 )
2018
8
Very High Frequency Oscillations of Heart Rate Variability in Healthy Humans and in Patients with Cardiovascular Autonomic Neuropathy. ( 29429029 )
2018
9
Seronegative autoimmune autonomic neuropathy: a distinct clinical entity. ( 29280036 )
2018
10
Correlation of retinal neurodegeneration with measures of peripheral autonomic neuropathy in type 1 diabetes. ( 29504257 )
2018
11
Autonomic Neuropathy-a Prospective Cohort Study of Symptoms and <i>E</i>/<i>I</i> Ratio in Normal Glucose Tolerance, Impaired Glucose Tolerance, and Type 2 Diabetes. ( 29593644 )
2018
12
Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs. ( 29643979 )
2018
13
Autoimmune autonomic neuropathies: time to look beyond autoimmune autonomic ganglionopathy. ( 29305816 )
2018
14
Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia. ( 29669327 )
2018
15
Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Cohort Study. ( 29292558 )
2018
16
Hereditary Sensory and Autonomic Neuropathy Presenting With Mutilating Trophic Ulcers. ( 29584606 )
2018
17
Combination of Ewing test, heart rate variability, and heart rate turbulence analysis for early diagnosis of diabetic cardiac autonomic neuropathy. ( 29137013 )
2017
18
Cardiovascular Autonomic Neuropathy Is an Independent Risk Factor for Left Ventricular Diastolic Dysfunction in Patients with Type 2 Diabetes. ( 28638827 )
2017
19
WNK1/HSN2 founder mutation in patients with hereditary sensory and autonomic neuropathy: A Japanese cohort study. ( 28422281 )
2017
20
Cardiovascular Autonomic Neuropathy and Cardiovascular Outcomes in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study. ( 27803120 )
2017
21
Clinical and metabolic consequences of L-serine supplementation in hereditary sensory and autonomic neuropathy type 1C. ( 29042446 )
2017
22
Analysis of a Screening System for Diabetic Cardiovascular Autonomic Neuropathy in China. ( 29125834 )
2017
23
Managing supine hypertension in a patient with non-diabetic autonomic neuropathy receiving droxidopa for neurogenic orthostatic hypotension. ( 28623420 )
2017
24
QTc prolongation in Black diabetic subjects with cardiac autonomic neuropathy. ( 29937880 )
2017
25
Editorial: Limited Utility of the Handgrip Test for the Diagnosis of Diabetic Cardiovascular Autonomic Neuropathy: &amp;quot;There's Time Enough, But None to Spare&amp;quot;. ( 27781938 )
2017
26
Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia. ( 28928996 )
2017
27
Posterior column ataxia with retinitis pigmentosa coexisting with sensory-autonomic neuropathy and leukemia due to the homozygous p.Pro221Ser FLVCR1 mutation. ( 28766925 )
2017
28
Acute autonomic neuropathy with severe gastrointestinal symptoms in children: a case series. ( 28841844 )
2017
29
Structured lifestyle intervention in patients with the metabolic syndrome mitigates oxidative stress but fails to improve measures of cardiovascular autonomic neuropathy. ( 28709739 )
2017
30
Anesthetic Management of a Patient With De Novo Hereditary Sensory and Autonomic Neuropathy, Type VII: A Case Report. ( 29077663 )
2017
31
Systemic Amyloidosis and Cardiac Autonomic Neuropathy Associated with Waldenstrom's Macroglobulinemia. ( 28695027 )
2017
32
Permutation entropy analysis of heart rate variability for the assessment of cardiovascular autonomic neuropathy in type 1 diabetes mellitus. ( 28527351 )
2017
33
Potential Association of Triglyceride Glucose Index with Cardiac Autonomic Neuropathy in Type 2 Diabetes Mellitus Patients. ( 28581270 )
2017
34
Oral manifestations, dental management, and a rare homozygous mutation of the PRDM12 gene in a boy with hereditary sensory and autonomic neuropathy type VIII: a case report and review of the literature. ( 28807049 )
2017
35
Continuous glucose monitoring adds information beyond HbA1c in well-controlled diabetes patients with early cardiovascular autonomic neuropathy. ( 28728915 )
2017
36
Autoimmunity, Autonomic Neuropathy, and the HPV Vaccination: A Vulnerable Subpopulation. ( 28868890 )
2017
37
Prevalence of Autonomic Neuropathy in Patients of Rheumatoid Arthritis and Its Correlation with Disease Severity. ( 28571182 )
2017
38
Cardiac autonomic neuropathy may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus. ( 28993155 )
2017
39
Pathogenetic Mechanisms of Outbreak and Development of Cardiac Autonomic Neuropathy in Patients with Metabolic Syndrome. ( 29124537 )
2017
40
Response: Effects of High-Dose I+-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea (Diabetes Metab J 2017;41:275-83). ( 29086541 )
2017
41
Effects of High-Dose I+-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea. ( 28868825 )
2017
42
Vitreous amyloidosis with autonomic neuropathy of the digestive tract associated with a novel transthyretin p.Gly87Arg variant in a Bangladeshi patient: a case report. ( 28802308 )
2017
43
Prediction of autonomic neuropathy in chronic kidney disease (stage 5) Iraqi patients (case control study). ( 28757390 )
2017
44
Cardiac autonomic neuropathy in patients with diabetes mellitus: current perspectives. ( 29062239 )
2017
45
Association of sleep apnoea syndrome and autonomic neuropathy in type 1 diabetes. ( 29169926 )
2017
46
Effect of ramipril/hydrochlorothiazide and ramipril/canrenone combination on atrial fibrillation recurrence in hypertensive type 2 diabetic patients with and without cardiac autonomic neuropathy. ( 28507568 )
2017
47
Delayed autonomic neuropathy in a patient with diethylene glycol poisoning: a case report. ( 29123883 )
2017
48
Glycated albumin and its variability as an indicator of cardiovascular autonomic neuropathy development in type 2 diabetic patients. ( 29017498 )
2017
49
Letter: Effects of High-Dose I+-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea (Diabetes Metab J 2017;41:275-83). ( 29086540 )
2017
50
A Comprehensive Functional Analysis of NTRK1 Missense Mutations Causing Hereditary Sensory and Autonomic Neuropathy Type IV (HSAN IV). ( 27676246 )
2017

Variations for Autonomic Neuropathy

Expression for Autonomic Neuropathy

Search GEO for disease gene expression data for Autonomic Neuropathy.

Pathways for Autonomic Neuropathy

Pathways related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 NGF NPY NTRK1 SCN9A
2
Show member pathways
9.66 NGF NTRK1

GO Terms for Autonomic Neuropathy

Cellular components related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.26 DST KIF1A NGF NTRK1
2 serine C-palmitoyltransferase complex GO:0017059 8.62 SPTLC1 SPTLC2

Biological processes related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.72 AKR1B1 ALB INS NGF NTRK1
2 negative regulation of neuron apoptotic process GO:0043524 9.65 NGF NTRK1 RETREG1
3 microtubule-based movement GO:0007018 9.63 KIF1A NGF NTRK1
4 ceramide biosynthetic process GO:0046513 9.51 SPTLC1 SPTLC2
5 positive regulation of Ras protein signal transduction GO:0046579 9.49 NGF NTRK1
6 neurotrophin TRK receptor signaling pathway GO:0048011 9.43 NGF NTRK1
7 nerve growth factor signaling pathway GO:0038180 9.4 NGF NTRK1
8 sphingosine biosynthetic process GO:0046512 9.37 SPTLC1 SPTLC2
9 sensory perception of pain GO:0019233 9.33 NTRK1 RETREG1 SCN9A
10 sphingomyelin biosynthetic process GO:0006686 9.26 SPTLC1 SPTLC2
11 positive regulation of lipophagy GO:1904504 8.96 SPTLC1 SPTLC2
12 sphinganine biosynthetic process GO:0046511 8.62 SPTLC1 SPTLC2

Molecular functions related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 9.13 ALB SPTLC1 SPTLC2
2 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC1 SPTLC2

Sources for Autonomic Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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