MCID: ATN004
MIFTS: 46

Autonomic Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Autonomic Neuropathy

MalaCards integrated aliases for Autonomic Neuropathy:

Name: Autonomic Neuropathy 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11504
NCIt 51 C27033
UMLS 74 C0259749

Summaries for Autonomic Neuropathy

MalaCards based summary : Autonomic Neuropathy is related to hereditary sensory and autonomic neuropathy type 1 and neuropathy, hereditary sensory and autonomic, type v. An important gene associated with Autonomic Neuropathy is RETREG1 (Reticulophagy Regulator 1), and among its related pathways/superpathways are Neuroscience and Activation of TRKA receptors. The drugs Quinapril and Bromocriptine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 77 Autonomic neuropathy (AN or AAN) is a form of polyneuropathy that affects the non-voluntary, non-sensory... more...

Related Diseases for Autonomic Neuropathy

Diseases related to Autonomic Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 hereditary sensory and autonomic neuropathy type 1 34.2 SPTLC1 SPTLC2
2 neuropathy, hereditary sensory and autonomic, type v 33.8 NGF NTRK1
3 neuropathy, hereditary sensory and autonomic, type iii 33.7 ELP1 NGF
4 neuropathy, hereditary sensory and autonomic, type ic 33.6 SPTLC1 SPTLC2
5 neuropathy, hereditary sensory, type ie 33.6 SPTLC1 SPTLC2
6 diabetic autonomic neuropathy 33.4 AKR1B1 INS NGF
7 neuropathy, hereditary sensory and autonomic, type iia 33.4 ELP1 KIF1A RETREG1 SCN9A WNK1
8 dysautonomia 32.5 ELP1 NTRK1
9 hereditary sensory neuropathy 32.1 ELP1 KIF1A NGF NTRK1 RETREG1 SPTLC1
10 neuropathy - hereditary 31.8 DST SPTLC1
11 sensory peripheral neuropathy 31.8 NGF NTRK1 SPTLC1
12 diabetic neuropathy 31.3 AKR1B1 INS NGF NTRK1 SCN9A
13 autonomic nervous system disease 30.6 ALB INS NGF NPY
14 neuropathy 30.5 DST ELP1 KIF1A NGF RETREG1 SCN9A
15 anhidrosis 30.3 NGF NTRK1
16 diabetic polyneuropathy 30.2 AKR1B1 NGF
17 microvascular complications of diabetes 3 30.0 ALB INS
18 acroosteolysis 29.8 ALB RETREG1
19 microvascular complications of diabetes 5 29.8 AKR1B1 ALB INS
20 diabetes mellitus, insulin-dependent 29.3 AKR1B1 ALB INS
21 peripheral nervous system disease 28.7 AKR1B1 ALB ELP1 INS NGF SCN9A
22 idiopathic peripheral autonomic neuropathy 12.3
23 insensitivity to pain, congenital, with anhidrosis 12.3
24 neuropathy, hereditary sensory and autonomic, type vii 12.2
25 neuropathy, hereditary sensory and autonomic, type viii 12.2
26 neuropathy, hereditary sensory and autonomic, type vi 12.2
27 neuropathy, hereditary sensory and autonomic, type ia 12.2
28 x-linked hereditary sensory and autonomic neuropathy with deafness 12.1
29 hereditary sensory and autonomic neuropathy with deafness and global delay 12.1
30 neuropathy, hereditary sensory and autonomic, type iib 12.0
31 spastic paraplegia 49, autosomal recessive 11.8
32 neuropathy, hereditary sensory and autonomic, type i, with cough and gastroesophageal reflux 11.8
33 autoimmune autonomic ganglionopathy 11.5
34 lipomatosis, multiple symmetric 11.4
35 deafness, x-linked 5 11.1
36 sptlc1-related hereditary sensory neuropathy 11.1
37 prp systemic amyloidosis 11.1
38 indifference to pain, congenital, autosomal recessive 11.1
39 neuropathy, hereditary sensory, type id 11.1
40 neuropathy, hereditary sensory, type iic 11.1
41 neuropathy, hereditary sensory, type if 11.1
42 autoimmune gastrointestinal dysmotility 11.1
43 ramos arroyo clark syndrome 11.1
44 familial syringomyelia 11.1
45 diabetes mellitus 10.8
46 hypoglycemia 10.4
47 askin's tumor 10.3 NGF NTRK1
48 prolactin producing pituitary tumor 10.3 NGF NTRK1
49 burning mouth syndrome 10.3 NGF SCN9A
50 arthritis 10.2

Graphical network of the top 20 diseases related to Autonomic Neuropathy:



Diseases related to Autonomic Neuropathy

Symptoms & Phenotypes for Autonomic Neuropathy

MGI Mouse Phenotypes related to Autonomic Neuropathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.1 AKR1B1 ELP1 INS KIF1A NGF NPY
2 growth/size/body region MP:0005378 10.07 AKR1B1 ELP1 INS KIF1A NGF NPY
3 mortality/aging MP:0010768 10 AKR1B1 ALB ELP1 INS KIF1A NGF
4 integument MP:0010771 9.92 ELP1 INS KIF1A NGF NTRK1 RETREG1
5 nervous system MP:0003631 9.65 ELP1 INS KIF1A NGF NPY NTRK1
6 muscle MP:0005369 9.63 ALB ELP1 INS NGF NTRK1 WNK1
7 renal/urinary system MP:0005367 9.17 AKR1B1 ALB ELP1 INS NPY SCN9A

Drugs & Therapeutics for Autonomic Neuropathy

Drugs for Autonomic Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
2
Bromocriptine Approved, Investigational Phase 4 25614-03-3 31101
3
Dopamine Approved Phase 4,Phase 3,Phase 2 62-31-7, 51-61-6 681
4
Vildagliptin Approved, Investigational Phase 4,Phase 2 274901-16-5 6918537
5
Midodrine Approved Phase 4 133163-28-7, 42794-76-3 4195
6
Droxidopa Approved, Investigational Phase 4,Phase 3,Phase 2 23651-95-8 443940
7
Norepinephrine Approved Phase 4,Phase 2,Not Applicable 51-41-2 439260
8
Liraglutide Approved Phase 4 204656-20-2 44147092
9
Donepezil Approved Phase 4,Not Applicable 120014-06-4 3152
10
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
12 Benphothiamine Phase 4
13 Adjuvants, Immunologic Phase 4
14 Chelating Agents Phase 4
15 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 HIV Protease Inhibitors Phase 4,Phase 2
17
protease inhibitors Phase 4,Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
19 Hormone Antagonists Phase 4,Phase 2,Not Applicable
20 Hormones Phase 4,Phase 2,Not Applicable
21 Hypoglycemic Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Dipeptidyl-Peptidase IV Inhibitors Phase 4,Phase 2
23 Incretins Phase 4,Not Applicable
24 Micronutrients Phase 4,Phase 3,Phase 1,Phase 2
25 Vitamin B9 Phase 4,Phase 3,Phase 1,Phase 2
26 Folate Phase 4,Phase 3,Phase 1,Phase 2
27 Thioctic Acid Phase 4
28 Protective Agents Phase 4,Phase 3,Phase 1
29 Trace Elements Phase 4,Phase 3,Phase 1,Phase 2
30 Vitamins Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
31 Nutrients Phase 4,Phase 3,Phase 1,Phase 2
32 Vitamin B Complex Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
33 Alpha-lipoic Acid Phase 4
34 Antioxidants Phase 4,Phase 3,Phase 1
35 Angiotensin-Converting Enzyme Inhibitors Phase 4
36 Antihypertensive Agents Phase 4,Not Applicable
37 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
38 Antiparkinson Agents Phase 4,Phase 3,Phase 2
39 Dopamine agonists Phase 4
40 Dopamine Agents Phase 4,Phase 3,Phase 2
41 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,... Phase 4
42 Sodium-Glucose Transporter 2 Inhibitors Phase 4
43 Adrenergic alpha-Agonists Phase 4,Phase 2
44 Adrenergic Agents Phase 4,Phase 3,Phase 2
45 Vasoconstrictor Agents Phase 4,Phase 2
46 Adrenergic Agonists Phase 4,Phase 3,Phase 2
47 Autonomic Agents Phase 4,Phase 3,Phase 2
48 Sympathomimetics Phase 4,Phase 3,Phase 2
49 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
50 Psychotropic Drugs Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 118)
# Name Status NCT ID Phase Drugs
1 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
2 Chronic Treatment With Benfotiamine Restores Endothelial Function in People With Type 2 Diabetes Mellitus Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
3 The Effect of α-lipoic Acid Treatment in Patient With Cardiac Autonomic Neuropathy Completed NCT02056366 Phase 4 α-lipoic acid
4 Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus Completed NCT03031834 Phase 4 Quinapril
5 Bromocriptine-QR Therapy on Sympathetic Tone and Vascular Biology in Type 2 Diabetes Subjects Completed NCT02682901 Phase 4 Cycloset;Placebo
6 Effects of DPP4 Inhibitor Versus SGLT2 Inhibitor Completed NCT03178591 Phase 4 vildagliptin;Dapagliflozin
7 A Study for Patients With Neurogenic Orthostatic Hypotension Completed NCT00046475 Phase 4 Midodrine Hydrochloride
8 Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension Recruiting NCT02586623 Phase 4 Droxidopa capsules;Placebo capsules
9 Effect of Liraglutide on Vascular Inflammation in Type-2 Diabetes Recruiting NCT03449654 Phase 4 Liraglutide;Placebo (for liraglutide)
10 A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension Terminated NCT00046163 Phase 4 midodrine hydrochloride (ProAmatine®)
11 Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy Terminated NCT00619983 Phase 4 donepezil;duloxetine;donepezil 2.5 mg and duloxetine 30mg;placebo;gabapentin
12 Pioglitazone in Impaired Glucose Tolerance Withdrawn NCT00306826 Phase 4 pioglitazone;simvastatin;pioglitazone + simvastatin
13 Fluid Retention in Rosiglitazone Treated Subjects With Autonomic Neuropathy. Completed NCT00422955 Phase 3 rosiglitazone
14 An Intervention Trial for Cardiac Neuropathy in Type 1 Diabetes Completed NCT00116207 Phase 3 ORAL ANTIOXIDANT
15 Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT) Completed NCT00594152 Phase 3 CIIIT
16 Carbidopa for the Treatment of Nausea and Vomiting in Familial Dysautonomia Completed NCT01212484 Phase 3 Carbidopa;Placebo
17 Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) Completed NCT00738062 Phase 3 Droxidopa;Placebo
18 Efficacy and Safety of Inotersen in Familial Amyloid Polyneuropathy Completed NCT01737398 Phase 2, Phase 3 Inotersen;Placebo
19 Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy Completed NCT01522235 Phase 2, Phase 3 Double blinded IVIg
20 The Effect of Diflunisal on Familial Amyloidosis Completed NCT00294671 Phase 2, Phase 3 diflunisal
21 APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis Completed NCT01960348 Phase 3 patisiran (ALN-TTR02);Sterile Normal Saline (0.9% NaCl)
22 Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer Completed NCT00516503 Phase 3 baclofen/amitriptyline/ketamine gel
23 An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid Polyneuropathy Completed NCT00791492 Phase 2, Phase 3 Fx-1006A
24 Safety and Efficacy Study of Fx-1006A in Patients With Familial Amyloidosis Completed NCT00409175 Phase 2, Phase 3 Fx-1006A;Placebo
25 The Effects Of Bronchodilator Therapy On Respiratory And Autonomic Function In Patients With Familial Dysautonomia Completed NCT01987219 Phase 3 Albuterol-sulphate;Ipratropium-bromide
26 Patisiran in Patients With Hereditary Transthyretin-mediated Amyloidosis (hATTR Amyloidosis) Disease Progression Post-Liver Transplant Recruiting NCT03862807 Phase 3 Patisiran
27 Effect of Autonomic Neuropathy on the Efficacy of a DPP-IV Inhibitor (Galvus) Therapy Completed NCT01452113 Phase 2 Vildagliptin
28 L-Serine Supplementation in Hereditary Sensory Neuropathy Type 1 Completed NCT01733407 Phase 1, Phase 2 L-serine;placebo
29 Bortezomib, Daunorubicin, and Cytarabine in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia Completed NCT00742625 Phase 1, Phase 2 daunorubicin hydrochloride;cytarabine;bortezomib
30 Efficacy and Safety of TAK-583 in Subjects With Diabetic Peripheral Neuropathy Completed NCT00760955 Phase 2 TAK-583;TAK-583;TAK-583;Placebo
31 A Multicenter Study Comparing the Analgesic Effects and Safety of ABT-639 Compared to Placebo in Subjects With Diabetic Neuropathic Pain Completed NCT01345045 Phase 2 ABT-639;pregabalin;Placebo
32 Evaluation of Diagnostic Methods and Dietary Treatment of Diabetic Gastroparesis Completed NCT01557296 Phase 2
33 The Effects of Fx-1006A on Transthyretin Stabilization and Clinical Outcome Measures in Patients With Non-V30M Transthyretin Amyloidosis Completed NCT00630864 Phase 2 Fx-1006A
34 Carbidopa for the Treatment of Excessive Blood Pressure Variability Recruiting NCT02553265 Phase 2 Carbidopa Low Dose;Carbidopa High Dose
35 The Safety, Tolerability and Efficacy of Dronabinol, for the Treatment of Nausea and Vomiting in Familial Dysautonomia Recruiting NCT02608931 Phase 2 Dronabinol
36 The Safety and Tolerability of Kinetin, in Patients With Familial Dysautonomia Recruiting NCT02274051 Phase 2
37 The Efficacy Of Intravenous Immunoglobulin Therapy In Treatment Induced Neuropathy Of Diabetes Recruiting NCT02915263 Phase 2 IGIV-C;0.9% Sodium Chloride
38 The Nutritional Supplement Phosphatidylserine in Patients With Familial Dysautonomia Recruiting NCT02276716 Phase 2 Phosphatidylserine
39 Nicotinamide Riboside for Diabetic Neuropathy Recruiting NCT03685253 Phase 1, Phase 2 Niagen;Placebo
40 A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis Withdrawn NCT02624310 Phase 2 Droxidopa (L-DOPS);Placebo
41 Cardiac Autonomic Neuropathy in Patients With Metabolic Syndrome Completed NCT00907127 Phase 1
42 N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer Withdrawn NCT01138137 Phase 1 Paclitaxel;N-acetylcysteine;Cisplatin
43 The Relationship Between Vascular Adhesion Protein-1 and Diabetic Cardiovascular Autonomic Neuropathy Unknown status NCT01706289
44 A Comparison Between Pupillometry, Heart Rate Variability and Metaiodobenzylguanidine Scintigraphy for the Diagnosis of Early Diabetic Autonomic Neuropathy in Type 1 Diabetes Unknown status NCT01822431
45 Effect of DPP-IV Inhibitor on Glycemic Control and Autonomic Neuropathy in Adult Patients With Diabetes Mellitus Unknown status NCT01545024 Sitagliptin, 50 mg once per day per os
46 Sleep Apnea in Type 1 Diabetes Unknown status NCT01935765 Early Phase 1
47 Detection no Invasive of a Silent Myocardial Ischemia Unknown status NCT02885428
48 Acute Effects of Inspiratory Muscle Exercise on Glucose Level and Glucose Variability in Patients With Type 2 Diabetes. Unknown status NCT02292810 Not Applicable
49 Inspiratory Muscle Training in Chronic Kidney Disease Unknown status NCT03082404 Not Applicable
50 Low-level Laser Therapy in Chronic Kidney Disease Unknown status NCT02944760 Not Applicable

Search NIH Clinical Center for Autonomic Neuropathy

Genetic Tests for Autonomic Neuropathy

Anatomical Context for Autonomic Neuropathy

MalaCards organs/tissues related to Autonomic Neuropathy:

42
Heart, Testes, Kidney, Skin, Liver, Brain, Spinal Cord

Publications for Autonomic Neuropathy

Articles related to Autonomic Neuropathy:

(show top 50) (show all 1472)
# Title Authors Year
1
Cardiovascular autonomic neuropathy and falls in Parkinson disease: a prospective cohort study. ( 30382389 )
2019
2
Decreased β-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes. ( 30430334 )
2019
3
Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes. ( 30599773 )
2019
4
Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. ( 30626650 )
2019
5
Diagnosis of cardiovascular autonomic neuropathy in diabetes: as simple as possible, but not simpler? An answer. ( 30734866 )
2019
6
Diagnosis of cardiovascular autonomic neuropathy in diabetes: as simple as possible, but not simpler? ( 30734867 )
2019
7
Cardiovascular autonomic neuropathy in type 2 diabetic patients. ( 30758421 )
2019
8
Nocturnal ventricular arrhythmias are associated with severity of cardiovascular autonomic neuropathy in type 2 diabetes. ( 30767398 )
2019
9
Diagnosing and managing diabetic somatic and autonomic neuropathy. ( 30783521 )
2019
10
Update on the Impact, Diagnosis and Management of Cardiovascular Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What Is Unmet. ( 30793549 )
2019
11
An update on the diagnosis and treatment of diabetic somatic and autonomic neuropathy. ( 30828432 )
2019
12
Is our treatment in type 1 diabetes mellitus (insulin therapy models, metabolic control) optimal for preventing cardiovascular autonomic neuropathy? ( 30845344 )
2019
13
Sleep duration is a significant predictor of cardiac autonomic neuropathy in type 2 diabetes mellitus. ( 30850339 )
2019
14
Clinical factors associated with the recovery of cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus. ( 30857534 )
2019
15
Hereditary sensory and autonomic neuropathy type IC (HSAN1C) accompanied by upper motor neuron abnormalities and type II juxtafoveal retinal telangiectasias. ( 30866134 )
2019
16
Clinical utility of SUDOSCAN in predicting autonomic neuropathy in patients with Parkinson's disease. ( 30890381 )
2019
17
Cardiovascular Autonomic Neuropathy and Glucose Variability in Patients With Type 1 Diabetes: Is There an Association? ( 29725320 )
2018
18
Repeated hyperhidrosis and chilblain-like swelling with ulceration of the fingers and toes in hereditary sensory and autonomic neuropathy type II. ( 29701257 )
2018
19
Toenail changes in autonomic neuropathy. ( 29923035 )
2018
20
Serum apolipoprotein A-1 concentrations and the prevalence of cardiovascular autonomic neuropathy in individuals with type 2 diabetes. ( 29453140 )
2018
21
Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients. ( 29693021 )
2018
22
Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment. ( 29359025 )
2018
23
The prognostic value of the frontal QRS-T angle is comparable to cardiovascular autonomic neuropathy regarding long-term mortality in people with diabetes. A population based study. ( 29775674 )
2018
24
Very High Frequency Oscillations of Heart Rate Variability in Healthy Humans and in Patients with Cardiovascular Autonomic Neuropathy. ( 29429029 )
2018
25
Seronegative autoimmune autonomic neuropathy: a distinct clinical entity. ( 29280036 )
2018
26
Correlation of retinal neurodegeneration with measures of peripheral autonomic neuropathy in type 1 diabetes. ( 29504257 )
2018
27
Autonomic Neuropathy-a Prospective Cohort Study of Symptoms and <i>E</i>/<i>I</i> Ratio in Normal Glucose Tolerance, Impaired Glucose Tolerance, and Type 2 Diabetes. ( 29593644 )
2018
28
Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs. ( 29643979 )
2018
29
Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia. ( 29669327 )
2018
30
Cardiovascular autonomic neuropathy in adolescents and young adults with type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Cohort Study. ( 29292558 )
2018
31
Hereditary Sensory and Autonomic Neuropathy Presenting With Mutilating Trophic Ulcers. ( 29584606 )
2018
32
Editorial: Autonomic Neuropathy and Cardiovascular Disease in Aging. ( 30379298 )
2018
33
Cardiomyopathy and autonomic neuropathy in hereditary amyloidosis: Defining the cart and the horse. ( 30565065 )
2018
34
Rituximab treatment in seronegative autoimmune autonomic neuropathy and autoimmune autonomic ganglionopathy: Case-report and literature review. ( 30468952 )
2018
35
Dystonin-A3 upregulation is responsible for maintenance of tubulin acetylation in a less severe dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI. ( 29982604 )
2018
36
A novel prion protein gene-truncating mutation causing autonomic neuropathy and diarrhea. ( 29984897 )
2018
37
Cardiovascular autonomic neuropathy and bone metabolism in Type 1 diabetes. ( 29999549 )
2018
38
A Nanowatt Real-Time Cardiac Autonomic Neuropathy Detector. ( 30010586 )
2018
39
Late-onset hereditary sensory and autonomic neuropathy expands the phenotypic spectrum of MFN2-related diseases. ( 30011089 )
2018
40
Progression of cardiovascular autonomic neuropathy and cardiovascular disease in type 2 diabetes. ( 30071872 )
2018
41
Involvement of P2Y12 receptor of stellate ganglion in diabetic cardiovascular autonomic neuropathy. ( 30084083 )
2018
42
Cardiac autonomic neuropathy in type 1 and type 2 diabetes patients. ( 30149797 )
2018
43
Cardiovascular autonomic neuropathy and distal symmetric sensorimotor polyneuropathy: these two diabetic microvascular complications do not invariably co-exist. ( 30156161 )
2018
44
Hereditary sensory and autonomic neuropathy in a male child: 'The other side of not feeling pain'. ( 30181410 )
2018
45
Knockdown the P2X3 receptor in the stellate ganglia of rats relieved the diabetic cardiac autonomic neuropathy. ( 30196147 )
2018
46
Cardiac Autonomic Neuropathy in Diabetes: A Predictor of Cardiometabolic Events. ( 30210276 )
2018
47
Office-Based Anesthetic and Oral Surgical Management of a Child With Hereditary Sensory Autonomic Neuropathy Type IV: A Case Report. ( 30235436 )
2018
48
Diabetic autonomic neuropathy resulting in sexual dysfunction. ( 30256272 )
2018
49
A cardiac risk score based on sudomotor function to evaluate cardiovascular autonomic neuropathy in asymptomatic Chinese patients with diabetes mellitus. ( 30281621 )
2018
50
Cardiovascular Autonomic Neuropathy Predicts Higher HbA1c Variability in Subjects with Type 2 Diabetes Mellitus. ( 30302965 )
2018

Variations for Autonomic Neuropathy

Expression for Autonomic Neuropathy

Search GEO for disease gene expression data for Autonomic Neuropathy.

Pathways for Autonomic Neuropathy

Pathways related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 NGF NPY NTRK1 SCN9A
2
Show member pathways
9.66 NGF NTRK1

GO Terms for Autonomic Neuropathy

Cellular components related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.02 DST KIF1A NGF NTRK1 SCN9A
2 serine C-palmitoyltransferase complex GO:0017059 8.96 SPTLC1 SPTLC2

Biological processes related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.63 NGF NTRK1 RETREG1
2 ceramide biosynthetic process GO:0046513 9.48 SPTLC1 SPTLC2
3 neurotrophin TRK receptor signaling pathway GO:0048011 9.43 NGF NTRK1
4 positive regulation of Ras protein signal transduction GO:0046579 9.4 NGF NTRK1
5 nerve growth factor signaling pathway GO:0038180 9.37 NGF NTRK1
6 sensory perception of pain GO:0019233 9.33 NTRK1 RETREG1 SCN9A
7 sphingosine biosynthetic process GO:0046512 9.32 SPTLC1 SPTLC2
8 sphingomyelin biosynthetic process GO:0006686 9.26 SPTLC1 SPTLC2
9 positive regulation of lipophagy GO:1904504 8.96 SPTLC1 SPTLC2
10 sphinganine biosynthetic process GO:0046511 8.62 SPTLC1 SPTLC2

Molecular functions related to Autonomic Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 9.13 ALB SPTLC1 SPTLC2
2 serine C-palmitoyltransferase activity GO:0004758 8.62 SPTLC1 SPTLC2

Sources for Autonomic Neuropathy

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35 ICD10 via Orphanet
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45 MeSH
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70 SNOMED-CT via HPO
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