Autosomal Dominant Non-Syndromic Intellectual Disability disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ATS203 MIFTS: 35	Autosomal Dominant Non-Syndromic Intellectual Disability Categories: Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases
Genes Variations Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Autosomal Dominant Non-Syndromic Intellectual Disability

MalaCards integrated aliases for Autosomal Dominant Non-Syndromic Intellectual Disability:

Name: Autosomal Dominant Non-Syndromic Intellectual Disability ¹² ⁵⁴ ⁶⁰ ¹⁵

Autosomal Dominant Mental Retardation ¹² ³⁸

Autosomal Dominant Non-Syndromic Mental Retardation ¹²

Mental Retardation, Autosomal Dominant ) ⁴¹

Mental Retardation, Autosomal Dominant ⁶

Characteristics:

Orphanet epidemiological data:

⁶⁰

autosomal dominant non-syndromic intellectual disability
Inheritance: Autosomal dominant;

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Neuronal diseases Mental diseases

See all MalaCards categories (disease lists)

Orphanet: ⁶⁰

Rare neurological diseases

External Ids:

Disease Ontology ¹² DOID:0060307

KEGG ³⁸ H00773

Orphanet ⁶⁰ ORPHA178469

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Summaries for Autosomal Dominant Non-Syndromic Intellectual Disability

Disease Ontology : ¹² A non-syndromic intellectual disability characterized by an autosomal dominant inheritance pattern.

MalaCards based summary : Autosomal Dominant Non-Syndromic Intellectual Disability, also known as autosomal dominant mental retardation, is related to autosomal dominant non-syndromic intellectual disability 1 and autosomal dominant non-syndromic intellectual disability 2. An important gene associated with Autosomal Dominant Non-Syndromic Intellectual Disability is SCN2A (Sodium Voltage-Gated Channel Alpha Subunit 2), and among its related pathways/superpathways are Dopaminergic synapse and Adrenergic signaling in cardiomyocytes. Related phenotypes are no effect and behavior/neurological

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Related Diseases for Autosomal Dominant Non-Syndromic Intellectual Disability

Diseases in the Non-Syndromic Intellectual Disability family:

Autosomal Dominant Non-Syndromic Intellectual Disability	Autosomal Recessive Non-Syndromic Intellectual Disability
Autosomal Dominant Non-Syndromic Intellectual Disability 1	Autosomal Dominant Non-Syndromic Intellectual Disability 2
Autosomal Dominant Non-Syndromic Intellectual Disability 3	Autosomal Dominant Non-Syndromic Intellectual Disability 4
Autosomal Dominant Non-Syndromic Intellectual Disability 5	Autosomal Dominant Non-Syndromic Intellectual Disability 6
Autosomal Dominant Non-Syndromic Intellectual Disability 8	Autosomal Dominant Non-Syndromic Intellectual Disability 9
Autosomal Dominant Non-Syndromic Intellectual Disability 19	Syngap1-Related Non-Syndromic Intellectual Disability

Diseases related to Autosomal Dominant Non-Syndromic Intellectual Disability via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)

#	Related Disease	Score
1	autosomal dominant non-syndromic intellectual disability 1	12.7
2	autosomal dominant non-syndromic intellectual disability 2	12.7
3	autosomal dominant non-syndromic intellectual disability 3	12.7
4	autosomal dominant non-syndromic intellectual disability 4	12.7
5	autosomal dominant non-syndromic intellectual disability 5	12.7
6	autosomal dominant non-syndromic intellectual disability 6	12.7
7	autosomal dominant non-syndromic intellectual disability 9	12.7
8	autosomal dominant non-syndromic intellectual disability 8	12.6
9	autosomal dominant non-syndromic intellectual disability 19	12.6
10	mental retardation, autosomal dominant 6, with or without seizures	12.6
11	mental retardation, autosomal dominant 55, with seizures	12.5
12	mental retardation, autosomal dominant 57	12.5
13	mental retardation, autosomal dominant 58	12.5
14	autosomal dominant mental retardation 55	12.2
15	mental retardation, autosomal dominant 7	12.0
16	mental retardation, autosomal dominant 10	12.0
17	mental retardation, autosomal dominant 11	12.0
18	mental retardation, autosomal dominant 13	12.0
19	mental retardation, autosomal dominant 21	12.0
20	mental retardation, autosomal dominant 24	12.0
21	mental retardation, autosomal dominant 32	12.0
22	mental retardation, autosomal dominant 35	12.0
23	mental retardation, autosomal dominant 38	12.0
24	mental retardation, autosomal dominant 41	12.0
25	mental retardation, autosomal dominant 43	12.0
26	neurodevelopmental disorder with spastic diplegia and visual defects	12.0
27	mental retardation, autosomal dominant 22	11.9
28	mental retardation, autosomal dominant 18	11.9
29	mental retardation, autosomal dominant 23	11.9
30	mental retardation, autosomal dominant 26	11.9
31	mental retardation, autosomal dominant 27	11.9
32	mental retardation, autosomal dominant 29	11.9
33	mental retardation, autosomal dominant 30	11.9
34	mental retardation, autosomal dominant 31	11.9
35	mental retardation, autosomal dominant 33	11.9
36	mental retardation, autosomal dominant 34	11.9
37	mental retardation, autosomal dominant 36	11.9
38	mental retardation, autosomal dominant 39	11.9
39	mental retardation, autosomal dominant 40	11.9
40	mental retardation, autosomal dominant 42	11.9
41	mental retardation, autosomal dominant 44	11.9
42	neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	11.6
43	adnp syndrome	11.3
44	coffin-siris syndrome 1	11.2
45	mental retardation, autosomal dominant 20	11.2
46	schuurs-hoeijmakers syndrome	11.2
47	xia-gibbs syndrome	11.2
48	helsmoortel-van der aa syndrome	11.2
49	white-sutton syndrome	11.2
50	microcephaly with or without chorioretinopathy, lymphedema, or mental retardation	11.2

Graphical network of the top 20 diseases related to Autosomal Dominant Non-Syndromic Intellectual Disability:

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Symptoms & Phenotypes for Autosomal Dominant Non-Syndromic Intellectual Disability

GenomeRNAi Phenotypes related to Autosomal Dominant Non-Syndromic Intellectual Disability according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	9.92	CACNG2 CAMK2A CAMK2B CDH15 CUX1 DEAF1

MGI Mouse Phenotypes related to Autosomal Dominant Non-Syndromic Intellectual Disability:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.16	CACNG2 CAMK2A CAMK2B DEAF1 DYNC1H1 EEF1A2
2	growth/size/body region	MP:0005378	10	CACNG2 CAMK2A CAMK2B DYNC1H1 EEF1A2 GRIN1
3	mortality/aging	MP:0010768	9.8	CACNG2 CAMK2A DEAF1 DYNC1H1 EEF1A2 GRIN1
4	nervous system	MP:0003631	9.58	CACNG2 CAMK2A CAMK2B DEAF1 DOCK8 DYNC1H1

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Drugs & Therapeutics for Autosomal Dominant Non-Syndromic Intellectual Disability

Search Clinical Trials , NIH Clinical Center for Autosomal Dominant Non-Syndromic Intellectual Disability

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Genetic Tests for Autosomal Dominant Non-Syndromic Intellectual Disability

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Anatomical Context for Autosomal Dominant Non-Syndromic Intellectual Disability

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Publications for Autosomal Dominant Non-Syndromic Intellectual Disability

Articles related to Autosomal Dominant Non-Syndromic Intellectual Disability:

#	Title	Authors	Year
1	Expanding the phenotype in autosomal dominant mental retardation-24: a novel variation in DEAF1 gene. ( 30451703 )	Sharma P...Mandal K	2019
2	Novel Mutation of SYNGAP1 Associated with Autosomal Dominant Mental Retardation 5 in a Chinese Patient. ( 30572772 )	Pei Y...Wei F	2018
3	[Autosomal dominant mental retardation]. ( 16506130 )	S?nchez-D?az A...Madrigal-Bajo I	2006

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Genes for Autosomal Dominant Non-Syndromic Intellectual Disability

Genes related to Autosomal Dominant Non-Syndromic Intellectual Disability (32 elite genes):

(show top 50) (show all 79)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SCN2A	Sodium Voltage-Gated Channel Alpha Subunit 2	Protein Coding	404.2	Pathogenic ⁶ DISEASES inferred ¹⁵
2	ZNF462	Zinc Finger Protein 462	Protein Coding	400	Pathogenic ⁶
3	SYNGAP1	Synaptic Ras GTPase Activating Protein 1	Protein Coding	354.69	Causative germline mutation ⁶⁰ DISEASES inferred ¹⁵
4	DEAF1	DEAF1 Transcription Factor	Protein Coding	354.4	Causative germline mutation ⁶⁰ DISEASES inferred ¹⁵
5	DYNC1H1	Dynein Cytoplasmic 1 Heavy Chain 1	Protein Coding	354.19	Causative germline mutation ⁶⁰ DISEASES inferred ¹⁵
6	KIF1A	Kinesin Family Member 1A	Protein Coding	353.81	Causative germline mutation ⁶⁰ DISEASES inferred ¹⁵
7	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	353.65	Causative germline mutation ⁶⁰ DISEASES inferred ¹⁵
8	STXBP1	Syntaxin Binding Protein 1	Protein Coding	353.62	Causative germline mutation ⁶⁰ DISEASES inferred ¹⁵
9	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	350	Causative germline mutation ⁶⁰
10	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	350	Causative germline mutation ⁶⁰
11	EEF1A2	Eukaryotic Translation Elongation Factor 1 Alpha 2	Protein Coding	350	Causative germline mutation ⁶⁰
12	EPB41L1	Erythrocyte Membrane Protein Band 4.1 Like 1	Protein Coding	350	Causative germline mutation ⁶⁰
13	CACNG2	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2	Protein Coding	350	Causative germline mutation ⁶⁰
14	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	350	Causative germline mutation ⁶⁰
15	CDH15	Cadherin 15	Protein Coding	350	Causative germline mutation ⁶⁰
16	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	350	Causative germline mutation ⁶⁰
17	MBD5	Methyl-CpG Binding Domain Protein 5	Protein Coding	350	Causative germline mutation ⁶⁰
18	KIRREL3	Kirre Like Nephrin Family Adhesion Molecule 3	Protein Coding	350	Causative germline mutation ⁶⁰
19	TCF4	Transcription Factor 4	Protein Coding	350	Causative germline mutation ⁶⁰
20	CUX1	Cut Like Homeobox 1	Protein Coding	350	Causative germline mutation ⁶⁰
21	CSNK2B	Casein Kinase 2 Beta	Protein Coding	350	Causative germline mutation (loss of function) ⁶⁰
22	CIC	Capicua Transcriptional Repressor	Protein Coding	350	Causative germline mutation (loss of function) ⁶⁰
23	ZMYND11	Zinc Finger MYND-Type Containing 11	Protein Coding	350	Causative germline mutation ⁶⁰
24	KCNQ5	Potassium Voltage-Gated Channel Subfamily Q Member 5	Protein Coding	350	Causative germline mutation ⁶⁰
25	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	350	Causative germline mutation ⁶⁰
26	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	350	Causative germline mutation ⁶⁰
27	SET	SET Nuclear Proto-Oncogene	Protein Coding	350	Causative germline mutation ⁶⁰
28	HIVEP2	Human Immunodeficiency Virus Type I Enhancer Binding Protein 2	Protein Coding	350	Causative germline mutation (loss of function) ⁶⁰
29	CHAMP1	Chromosome Alignment Maintaining Phosphoprotein 1	Protein Coding	350	Causative germline mutation ⁶⁰
30	CLTC	Clathrin Heavy Chain	Protein Coding	350	Causative germline mutation ⁶⁰
31	MYT1L	Myelin Transcription Factor 1 Like	Protein Coding	25	Candidate gene tested ⁶⁰
32	KDM5B	Lysine Demethylase 5B	Protein Coding	25	Candidate gene tested ⁶⁰
33	ARID1B	AT-Rich Interaction Domain 1B	Protein Coding	18.33	DISEASES inferred ¹⁵
34	SMARCE1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1	Protein Coding	17.74	DISEASES inferred ¹⁵
35	AHDC1	AT-Hook DNA Binding Motif Containing 1	Protein Coding	17.42	DISEASES inferred ¹⁵
36	BANF1	Barrier To Autointegration Factor 1	Protein Coding	17.04	DISEASES inferred ¹⁵
37	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	17.02	DISEASES inferred ¹⁵
38	ADNP	Activity Dependent Neuroprotector Homeobox	Protein Coding	16.99	DISEASES inferred ¹⁵
39	SMARCA2	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2	Protein Coding	16.69	DISEASES inferred ¹⁵
40	CHSY1	Chondroitin Sulfate Synthase 1	Protein Coding	16.68	DISEASES inferred ¹⁵
41	PHF6	PHD Finger Protein 6	Protein Coding	16.44	DISEASES inferred ¹⁵
42	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	16.34	DISEASES inferred ¹⁵
43	PACS1	Phosphofurin Acidic Cluster Sorting Protein 1	Protein Coding	16.33	DISEASES inferred ¹⁵
44	ARID2	AT-Rich Interaction Domain 2	Protein Coding	16.26	DISEASES inferred ¹⁵
45	SOX11	SRY-Box 11	Protein Coding	16.13	DISEASES inferred ¹⁵
46	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	16.08	DISEASES inferred ¹⁵
47	ARL6IP6	ADP Ribosylation Factor Like GTPase 6 Interacting Protein 6	Protein Coding	15.83	DISEASES inferred ¹⁵
48	CHSY3	Chondroitin Sulfate Synthase 3	Protein Coding	6.82	DISEASES inferred ¹⁵
49	CAPNS2	Calpain Small Subunit 2	Protein Coding	6.81	DISEASES inferred ¹⁵
50	CHPF	Chondroitin Polymerizing Factor	Protein Coding	6.59	DISEASES inferred ¹⁵

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Variations for Autosomal Dominant Non-Syndromic Intellectual Disability

ClinVar genetic disease variations for Autosomal Dominant Non-Syndromic Intellectual Disability:

⁶ (show all 14)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	KAT6B	NM_012330.3(KAT6B): c.3544G> A (p.Glu1182Lys)	single nucleotide variant	Likely benign	rs1057519623	GRCh38	Chromosome 10, 75025129: 75025129
2	KAT6B	NM_012330.3(KAT6B): c.3544G> A (p.Glu1182Lys)	single nucleotide variant	Likely benign	rs1057519623	GRCh37	Chromosome 10, 76784887: 76784887
3	NAA10	NM_003491.3(NAA10): c.583C> T (p.Arg195Cys)	single nucleotide variant	Likely benign	rs1057519620	GRCh38	Chromosome X, 153930112: 153930112
4	NAA10	NM_003491.3(NAA10): c.583C> T (p.Arg195Cys)	single nucleotide variant	Likely benign	rs1057519620	GRCh37	Chromosome X, 153195565: 153195565
5	SMARCA2	NM_003070.4(SMARCA2): c.2329C> G (p.Leu777Val)	single nucleotide variant	Uncertain significance	rs771591197	GRCh37	Chromosome 9, 2081976: 2081976
6	SMARCA2	NM_003070.4(SMARCA2): c.2329C> G (p.Leu777Val)	single nucleotide variant	Uncertain significance	rs771591197	GRCh38	Chromosome 9, 2081976: 2081976
7	SCN2A	NM_021007.2(SCN2A): c.3697G> T (p.Glu1233Ter)	single nucleotide variant	Pathogenic	rs1057519617	GRCh37	Chromosome 2, 166226657: 166226657
8	SCN2A	NM_021007.2(SCN2A): c.3697G> T (p.Glu1233Ter)	single nucleotide variant	Pathogenic	rs1057519617	GRCh38	Chromosome 2, 165370147: 165370147
9	ZNF462	NM_021224.5(ZNF462): c.3787C> T (p.Arg1263Ter)	single nucleotide variant	Pathogenic	rs1060499549	GRCh37	Chromosome 9, 109689980: 109689980
10	ZNF462	NM_021224.5(ZNF462): c.3787C> T (p.Arg1263Ter)	single nucleotide variant	Pathogenic	rs1060499549	GRCh38	Chromosome 9, 106927699: 106927699
11	ZNF462	NM_021224.5(ZNF462): c.4263delA (p.Glu1422Serfs)	deletion	Pathogenic	rs1060499551	GRCh37	Chromosome 9, 109690456: 109690456
12	ZNF462	NM_021224.5(ZNF462): c.4263delA (p.Glu1422Serfs)	deletion	Pathogenic	rs1060499551	GRCh38	Chromosome 9, 106928175: 106928175
13	ZNF462	NM_021224.5(ZNF462): c.2979_2980delTGinsA (p.Val994Trpfs)	indel	Pathogenic	rs1060499550	GRCh37	Chromosome 9, 109689172: 109689173
14	ZNF462	NM_021224.5(ZNF462): c.2979_2980delTGinsA (p.Val994Trpfs)	indel	Pathogenic	rs1060499550	GRCh38	Chromosome 9, 106926891: 106926892

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Expression for Autosomal Dominant Non-Syndromic Intellectual Disability

Search GEO for disease gene expression data for Autosomal Dominant Non-Syndromic Intellectual Disability.

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Pathways for Autosomal Dominant Non-Syndromic Intellectual Disability

Pathways related to Autosomal Dominant Non-Syndromic Intellectual Disability according to KEGG:

³⁸

#	Name	Kegg Source Accession
1	Dopaminergic synapse	hsa04728
2	Adrenergic signaling in cardiomyocytes	hsa04261
3	cAMP signaling pathway	hsa04024

Pathways related to Autosomal Dominant Non-Syndromic Intellectual Disability according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁷ Show member pathways Axon guidance ⁶⁷	13.19	CACNG2 CAMK2A CAMK2B CDH15 GRIN1 GRIN2B
2	Transmission across Chemical Synapses ⁶⁷ Show member pathways Neuronal System ⁶⁷ Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ⁶⁷	12.66	CACNG2 CAMK2A CAMK2B EPB41L1 GRIN1 GRIN2B
3	Neuropathic Pain-Signaling in Dorsal Horn Neurons ⁶⁵ Show member pathways Aldosterone Signaling in Epithelial Cells ⁶⁵ Cholera Infection ⁶⁵	12.45	CAMK2A CAMK2B GRIN1 GRIN2B SCN2A
4	WNT Signaling ⁶⁵	12.22	CAMK2A CAMK2B CDH15 TCF4
5	cAMP signaling pathway ³⁸	12.14	CAMK2A CAMK2B GRIN1 GRIN2B
6	Post NMDA receptor activation events ⁶⁷ Show member pathways Activation of AMPA receptors ⁶⁷ Activation of CaMK IV ⁶⁷ Activation of NMDA receptor upon glutamate binding and postsynaptic events ⁶⁷ CaMK IV-mediated phosphorylation of CREB ⁶⁷ CREB phosphorylation through the activation of CaMKII ⁶⁷ CREB phosphorylation through the activation of CaMKK ⁶⁷ CREB phosphorylation through the activation of Ras ⁶⁷ Ras activation uopn Ca2+ infux through NMDA receptor ⁶⁷ RSK activation ⁶⁷ Unblocking of NMDA receptor, glutamate binding and activation ⁶⁷	12.05	CAMK2A CAMK2B GRIN1 GRIN2B
7	Long-term potentiation ³⁸ Show member pathways Common Pathways Underlying Drug Addiction ¹ Dopamine D1-Like Receptor Family Signaling Pathways ⁶⁶	11.95	CAMK2A CAMK2B GRIN1 GRIN2B
8	Protein-protein interactions at synapses ⁶⁷ Show member pathways Interactions of neurexins and neuroligins at synapses ⁶⁷	11.82	EPB41L1 GRIN1 GRIN2B STXBP1
9	Cell cycle Cell cycle (generic schema) ²³ Show member pathways Cell cycle Regulation of G1/S transition (part 2) ²³ G0 and Early G1 ⁶⁷ G2 Phase ⁶⁷	11.77	CAMK2A CAMK2B CDH15 TCF4
10	Neuroscience ⁴	11.76	CACNG2 CAMK2A CAMK2B GRIN1 GRIN2B SCN2A
11	Amphetamine addiction ³⁸ Show member pathways Cocaine addiction ³⁸	11.74	CAMK2A CAMK2B GRIN1 GRIN2B
12	Non-Canonical Wnt Pathway ⁶⁸	11.45	CAMK2A CAMK2B TCF4
13	Phase 0 - rapid depolarisation ⁶⁷ Show member pathways Phase 2 - plateau phase ⁶⁷	11.33	CACNG2 CAMK2A CAMK2B SCN2A
14	Signal transduction_Erk Interactions- Inhibition of Erk ²³	11.13	CAMK2A CAMK2B GRIN1 GRIN2B
15	SALM protein interactions at the synapses ⁶⁷	10.87	GRIN1 GRIN2B

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GO Terms for Autosomal Dominant Non-Syndromic Intellectual Disability

Cellular components related to Autosomal Dominant Non-Syndromic Intellectual Disability according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	synapse	GO:0045202	9.73	CACNG2 CAMK2A CAMK2B EEF1A2 GRIN1 GRIN2B
2	glutamatergic synapse	GO:0098978	9.72	CACNG2 GRIN1 SCN2A STXBP1 SYNGAP1
3	postsynaptic density	GO:0014069	9.55	CACNG2 CAMK2A GRIN1 GRIN2B SYNGAP1
4	endocytic vesicle membrane	GO:0030666	9.54	CACNG2 CAMK2A CAMK2B
5	NMDA selective glutamate receptor complex	GO:0017146	9.4	GRIN1 GRIN2B
6	postsynaptic density membrane	GO:0098839	9.13	CACNG2 GRIN1 GRIN2B
7	neuron projection	GO:0043005	9.1	CACNG2 CAMK2A CAMK2B GRIN1 GRIN2B KIF1A
8	plasma membrane	GO:0005886	10.17	CACNG2 CAMK2A CDH15 DOCK8 EPB41L1 GRIN1

Biological processes related to Autosomal Dominant Non-Syndromic Intellectual Disability according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	nervous system development	GO:0007399	9.83	CAMK2B DEAF1 MBD5 SCN2A TCF4
2	ionotropic glutamate receptor signaling pathway	GO:0035235	9.49	GRIN1 GRIN2B
3	regulation of neuronal synaptic plasticity	GO:0048168	9.48	CAMK2A GRIN1
4	regulation of neuron migration	GO:2001222	9.46	CAMK2A CAMK2B
5	regulation of synaptic plasticity	GO:0048167	9.43	GRIN1 GRIN2B SYNGAP1
6	positive regulation of cysteine-type endopeptidase activity	GO:2001056	9.4	GRIN1 GRIN2B
7	excitatory chemical synaptic transmission	GO:0098976	9.37	GRIN1 GRIN2B
8	visual learning	GO:0008542	9.33	DEAF1 GRIN1 SYNGAP1
9	calcium ion transmembrane import into cytosol	GO:0097553	9.32	GRIN1 GRIN2B
10	MAPK cascade	GO:0000165	9.13	GRIN1 GRIN2B SYNGAP1
11	regulation of long-term neuronal synaptic plasticity	GO:0048169	8.8	CAMK2B GRIN1 SYNGAP1

Molecular functions related to Autosomal Dominant Non-Syndromic Intellectual Disability according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	glycine binding	GO:0016594	9.32	GRIN1 GRIN2B
2	ionotropic glutamate receptor activity	GO:0004970	9.26	GRIN1 GRIN2B
3	glutamate binding	GO:0016595	9.16	GRIN1 GRIN2B
4	NMDA glutamate receptor activity	GO:0004972	8.96	GRIN1 GRIN2B
5	glutamate-gated calcium ion channel activity	GO:0022849	8.62	GRIN1 GRIN2B

Sources

Sources for Autosomal Dominant Non-Syndromic Intellectual Disability

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia