Avascular Necrosis (AVN)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Avascular Necrosis

Summaries for Avascular Necrosis

MalaCards based summary : Avascular Necrosis, also known as avn, is related to familial avascular necrosis of the femoral head and osteonecrosis. An important gene associated with Avascular Necrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways is Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway. The drugs Melatonin and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Wikipedia : 75 Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

Related Diseases for Avascular Necrosis

Diseases in the Avascular Necrosis family:

Rare Hereditary Disease with Avascular Necrosis Secondary Avascular Necrosis
Primary Avascular Necrosis

Diseases related to Avascular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 308)
# Related Disease Score Top Affiliating Genes
1 familial avascular necrosis of the femoral head 34.6 TRPV4 COL2A1
2 osteonecrosis 32.7 COL2A1 BMP2 ABCB1
3 skeletal dysplasias 30.2 TRPV4 COL2A1
4 bone resorption disease 29.3 TNFRSF11A BMP2
5 avascular necrosis of femoral head, primary, 1 13.0
6 avascular necrosis of femoral head, primary, 2 12.7
7 idiopathic avascular necrosis 12.6
8 traumatic avascular necrosis 12.6
9 secondary avascular necrosis 12.5
10 primary avascular necrosis 12.5
11 avascular necrosis of genetic origin 12.4
12 secondary non-traumatic avascular necrosis 12.4
13 rare hereditary disease with avascular necrosis 12.4
14 legg-calve-perthes disease 12.3
15 dieterich's disease 11.7
16 dyskeratosis congenita 11.7
17 thiemann disease 11.3
18 arthrogryposis, perthes disease, and upward gaze palsy 11.3
19 dysbaric osteonecrosis 11.3
20 freiberg's disease 11.3
21 pr interval, variation in 11.2
22 systemic lupus erythematosus 10.7
23 sickle cell disease 10.7
24 lupus erythematosus 10.7
25 slipped capital femoral epiphysis 10.6
26 osteoarthritis 10.6
27 alcohol dependence 10.5
28 lymphocytic leukemia 10.5
29 sickle cell anemia 10.4
30 graft-versus-host disease 10.4
31 leukemia, acute lymphoblastic 10.4
32 gaucher's disease 10.4
33 vasculitis 10.4
34 osteoporosis 10.4
35 bone mineral density quantitative trait locus 8 10.4
36 bone mineral density quantitative trait locus 15 10.4
37 hydrops, lactic acidosis, and sideroblastic anemia 10.4
38 thalassemia 10.4
39 osteochondrosis 10.4
40 thoracoabdominal syndrome 10.3
41 osteomyelitis 10.3
42 gout 10.3
43 alcohol use disorder 10.3
44 thrombophilia 10.3
45 antiphospholipid syndrome 10.3
46 septic arthritis 10.3
47 hemoglobinopathy 10.3
48 arthropathy 10.3
49 osteochondritis dissecans 10.3
50 47,xyy 10.3

Graphical network of the top 20 diseases related to Avascular Necrosis:

Diseases related to Avascular Necrosis

Symptoms & Phenotypes for Avascular Necrosis

MGI Mouse Phenotypes related to Avascular Necrosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 ABCB1 BMP2 COL2A1 NEK9 SREBF2 TNFRSF11A
2 digestive/alimentary MP:0005381 9.62 ABCB1 BMP2 COL2A1 TNFRSF11A
3 hearing/vestibular/ear MP:0005377 9.56 ABCB1 BMP2 COL2A1 TRPV4
4 liver/biliary system MP:0005370 9.26 ABCB1 COL2A1 SREBF2 TNFRSF11A
5 mortality/aging MP:0010768 9.1 ABCB1 BMP2 COL2A1 NEK9 SREBF2 TNFRSF11A

Drugs & Therapeutics for Avascular Necrosis

Drugs for Avascular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 268)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
2 Central Nervous System Depressants Phase 4
3 Antioxidants Phase 4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
leucovorin Approved Phase 3 58-05-9 143 6006
Mercaptopurine Approved Phase 3 50-44-2 667490
Pegaspargase Approved, Investigational Phase 3 130167-69-0
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
Idarubicin Approved Phase 3 58957-92-9 42890
Thioguanine Approved Phase 3 154-42-7 2723601
Daunorubicin Approved Phase 3 20830-81-3 30323
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
Zoledronic Acid Approved Phase 3 118072-93-8 68740
Denosumab Approved Phase 3 615258-40-7
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
22 Antimetabolites Phase 3
23 Anti-Bacterial Agents Phase 3
24 Antibiotics, Antitubercular Phase 3
25 Calcium, Dietary Phase 3
26 Calciferol Phase 3
27 Anti-Infective Agents Phase 3
28 Alkylating Agents Phase 3
29 Folic Acid Antagonists Phase 3
30 Nucleic Acid Synthesis Inhibitors Phase 3
31 Vitamin B9 Phase 3
32 Folate Phase 3
33 Vitamin B Complex Phase 3
34 Immunosuppressive Agents Phase 3
35 Dermatologic Agents Phase 3
36 Immunologic Factors Phase 3
37 Antimetabolites, Antineoplastic Phase 3
38 Antirheumatic Agents Phase 3
39 Antineoplastic Agents, Alkylating Phase 3
40 Ibandronic Acid Phase 3
41 Topoisomerase Inhibitors Phase 3
42 Tubulin Modulators Phase 3
Liposomal doxorubicin Phase 3 31703
44 Antineoplastic Agents, Phytogenic Phase 3
asparaginase Phase 3
46 Antimitotic Agents Phase 3
47 Antiviral Agents Phase 3
48 Diphosphonates Phase 3
49 Bone Density Conservation Agents Phase 3
50 glucocorticoids Phase 3

Interventional clinical trials:

(show top 50) (show all 121)
# Name Status NCT ID Phase Drugs
1 Randomized, Prospective, Multi-center, Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
2 Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. Completed NCT03368430 Phase 4 Placebo
3 Post Approval Study: NOVATION Ceramic Articulation Hip System A Multi-Center, Open-Label Study to Evaluate the Mid and Long-Term Safety and Effectiveness of the Exactech NOVATION Ceramic Articulation Hip System Recruiting NCT00715143 Phase 4
4 Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery Recruiting NCT03190642 Phase 4 Methylprednisolone
5 Control Study of Implantation of Enriched Bone Marrow Cells for the Treatment of Avascular Necrosis of Femoral Head Unknown status NCT01613612 Phase 2, Phase 3
6 Multicenter, Open-labeled, Randomized Clinical Trial to Determine the Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head Completed NCT00939900 Phase 3 zoledronic acid (aclasta)
7 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
8 Treatment of Patients With Acute Lymphoblastic Leukemia With Unfavorable Features: A Phase III Group-wide Study Completed NCT00002812 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;idarubicin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
9 Use of the dermaPACE™ (Pulsed Acoustic Cellular Expression) Device in Conjunction With Standard of Care in the Treatment of Diabetic Foot Ulcers Completed NCT00536744 Phase 3
10 Combined Treatment of Early and Advanced Osteonecrosis of the Femoral Head With Core Decompression and Grafting With Demineralized Bone Matrix (DBM) or Homologous Lyophilized Bone Chips (LBC) Together With Platelet-rich-fibrin (PRF) and Concentrated Bone Marrow (CBM) Active, not recruiting NCT01892514 Phase 3
11 Efficacy of Denosumab and Zoledronic Acid in the Treatment of Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density: a Prospective Controlled Trial Not yet recruiting NCT04034199 Phase 3 Denosumab;Zoledronic Acid
12 Restoration of Muscle Following Hip Surgery Completed NCT00393848 Phase 2 Essential amino acid supplement;Ketoconazole;Placebo
13 Treatment of Osteonecrosis of the Femoral Head by Implantation of Preosteoblastic Cells: a Randomized, Controlled, Single Blind Pilot Study Completed NCT02890537 Phase 2 Core decompression/PREOB® implantation;Core decompression/BMC implantation
14 Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients With Steroid-refractory GVHD- A Phase I/II Clinical Trial Completed NCT02824653 Phase 1, Phase 2
15 A Randomized Trial of Interleukin-2 With or Without a Tumor Necrosis Factor Antagonist in Patients With HIV-1 Infection Completed NCT00001475 Phase 2 IL-2 plus Anti-TNF or Thalidomide
16 A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults With Severe Sickle Cell Disease (BMT CTN #1503) Recruiting NCT02766465 Phase 2 Busulfan;Fludarabine;r-ATG;Tacrolimus;Methotrexate
17 Transcranial Direct Current Stimulation Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease Recruiting NCT02813629 Phase 2
18 Evaluation of Safety and Feasibility of Bone Marrow Derived Autologous MSCs to Enhance Bone Healing in Patients With Avascular Necrosis of the Femoral Head Active, not recruiting NCT02065167 Phase 2
19 Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease Active, not recruiting NCT02448121 Phase 1, Phase 2
20 A Pilot Clinical Trial of "ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue (XCEL-MT-OSTEO- ALPHA) in Osteonecrosis of the Femoral Head Active, not recruiting NCT01605383 Phase 1, Phase 2
21 AVN Prevention With Lipitor in Lupus Erythematosus APLLE Trial Terminated NCT00412841 Phase 2 Atorvastatin;Placebo
22 Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis Withdrawn NCT01932554 Phase 2 Abciximab;Placebo;Ibuprofen;Parenteral narcotic
23 A Phase I/IIa Study of the Treatment of None-Infectious Anterior, Intermediate, Posterior and Panuveitis, With the Use of Dexamethasone Delivered by a Iontophoresis Device Withdrawn NCT00499551 Phase 1, Phase 2
24 Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation for Human Avascular Necrosis of the Lunate Bone of the Wrist (Kienbock`s Disease) Unknown status NCT02646007 Phase 1
25 Bone Marrow Derived CD133+ Stem Cells Transplantation in Femoral Head Osteonecrosis Completed NCT01198080 Phase 1
26 Evaluation of Endothelial and Hemodynamic Function in HIV Associated Pulmonary Hypertension and a Phase I/II Safety and Efficacy Trial of Sildenafil in HIV Associated Pulmonary Hypertension Terminated NCT00327080 Phase 1 L-NMMA;Acetylcholine
27 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Autografting Unknown status NCT02289976
28 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Auto Grafting Unknown status NCT02291900
29 Femoral Head Resurfacing Versus a Large Femoral Head (Durom®) Total Hip System: A Prospective Randomized Trial Unknown status NCT00175487
30 Porous Tantalum Rods Improve the Hip Joint Function of Patients With Avascular Necrosis of the Femoral Head After Femoral Neck Fracture Surgery: a Randomized Controlled Trial Unknown status NCT02877472
31 Molecular Genetic Study of Avascular Necrosis of the Femoral Head-Revealing ANFH Pathogenesis Mechanism by Cell and Animal Models Unknown status NCT00260897
32 Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up Unknown status NCT00172315
33 Feasibility of Implantation of Cemented Femoral Stem in the Treatment of Osteoporotic Femoral Neck Fracture in Elderly Patients: a Randomized Controlled Trial Unknown status NCT02901938
34 Tolerance Induction in Living Donor Kidney Transplantation With Hematopoietic Stem Cell Transplantation Unknown status NCT02199301
35 Universal Ultrasound-screening for Developmental Dysplasia of the Hip. 5-12 Years Followup of 4 200 Newborns Unknown status NCT01053299
36 Intracapsular Femoral Neck Fractures Fixation With a Dynamic Locking Plate and Screw System, Targon FN. Prospective and Retrospective Cohort Study. Unknown status NCT00830687
37 A Randomized Study of Non-Operative Management Versus Expedited Surgery Among WCB Patients With Small Rotator Cuff Tears: Affect Upon Time to Claim Closure in 2 Prairie Provinces Unknown status NCT01498198
38 Safety and Efficacy of Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral Head Completed NCT01643655
39 Relations Between Hematologic Variables and Postoperative Bleeding in Total Hip Replacement Arthroplasty Completed NCT01521858
40 Total Temporomandibular Joint Replacement System Post Approval Study Completed NCT00762944
41 Randomized Study of Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease Completed NCT00006130
42 Decellularization of Umbilical Cord Wharton's Jelly for Tissue Regenerative Applications Including Avascular Necrosis Completed NCT01166776
43 Hemostatic Changes After Colloid Fluid Administration During Total Hip Replacement Arthroplasty Completed NCT01512628 Pentaspan, voluven, volulyte
44 Relations Between Hematologic Variables and Postoperative Bleeding and Transfusion in Revision Total Hip Replacement Arthroplasty Completed NCT02951741
45 Study Of Pharmacogenetic Risk Factors For Avascular Necrosis CCG 1882 Completed NCT00898469
46 WEUKBRE5716: Quantifying the Burden of Steroid-related Damage in Systemic Lupus Erythematosus in the Hopkins Lupus Cohort Completed NCT01616472 Cumulative corticosteroid exposure
47 Magnetic Resonance Imaging to Study Avascular Necrosis in HIV-Infected Subjects Completed NCT00001762
48 Cormet Hip Resurfacing System Post-PMA Study Group (New Enrollment) Completed NCT00722007
49 Cormet Resurfacing Hip System Post PMA Approval Study (PMA #P050016)Pre-market (IDE) Study Group 10 Year Follow-Up With Metal Ion and Renal Function Data Collection Clinical Investigation Plan Completed NCT00721994
50 Autologous Perichondrium Transplantation for Replacement of Stem Cells and Their Niche in the Treatment of Necrotizing Scleritis Completed NCT02864823

Search NIH Clinical Center for Avascular Necrosis

Genetic Tests for Avascular Necrosis

Anatomical Context for Avascular Necrosis

MalaCards organs/tissues related to Avascular Necrosis:

Bone, Bone Marrow, Endothelial, Liver, Kidney, Heart, Myeloid

Publications for Avascular Necrosis

Articles related to Avascular Necrosis:

(show top 50) (show all 6106)
# Title Authors PMID Year
Timing of initiation of enzyme replacement therapy after diagnosis of type 1 Gaucher disease: effect on incidence of avascular necrosis. 9 38
19732054 2009
Imiglucerase (Cerezyme) improves quality of life in patients with skeletal manifestations of Gaucher disease. 9 38
17539908 2007
Treatment of Unstable Versus Stable Slipped Capital Femoral Epiphysis Using the Modified Dunn Procedure. 38
31393301 2019
The outcome of in-situ fixation of unstable slipped capital femoral epiphysis. 38
30702638 2019
Avascular necrosis of the capitate: case series of five patients and review of literature. 38
31142182 2019
Microarray analysis of long-noncoding RNAs and mRNA expression profiles in human steroid-induced avascular necrosis of the femoral head. 38
31081170 2019
Traction does not decrease failure of reduction and femoral head avascular necrosis in patients aged 6-24 months with developmental dysplasia of the hip treated by closed reduction: a review of 385 patients and meta-analysis. 38
30585878 2019
Medial Buttress Plating for Humerus Fractures With Unstable Medial Column. 38
31188258 2019
Developmental dysplasia of the hip and clubfoot treated by Pavlik and Ponseti methods. 38
31246178 2019
Osteonecrosis of the External Auditory Canal Associated With Oral Sorafenib Therapy: Sorafenib and Temporal Bone Osteonecrosis. 38
31356482 2019
Hip arthrodiastasis combined with core decompression and diamond concept for postcollapse femoral head avascular necrosis. 38
31413061 2019
Unipolar allograft reconstruction for post-traumatic avascular necrosis of the distal tibia: A review of the literature, technique, and case series. 38
30321950 2019
[The modified Dunn procedure to treat severe slipped capital femoral epiphysis]. 38
31267140 2019
[Early and late complications and their management in slipped capital femoral epiphysis]. 38
31025044 2019
Degenerative changes of the hip following in situ fixation for slipped capital femoral epiphysis: a minimum 18-year follow-up study. 38
31379207 2019
Comparison of Surgical Outcomes Between a Triplane Proximal Femoral Osteotomy and the Modified Dunn Procedure for Stable, Moderate to Severe Slipped Capital Femoral Epiphysis. 38
31305376 2019
Ginsenoside Rb1 prevents steroid‑induced avascular necrosis of the femoral head through the bone morphogenetic protein‑2 and vascular endothelial growth factor pathway. 38
31432121 2019
[Value of virtual reality technology in preoperative planning of transtrochanteric curved varus osteotomy for avascular necrosis of femoral head in adults]. 38
31407547 2019
The Role of Vascularized Bone Grafting in Scaphoid Nonunion. 38
31178089 2019
Does Anyone Need a Vascularized Graft? 38
31178090 2019
The Community Orthopaedic Surgeon Taking Trauma Call: Lateral Humeral Condyle Fracture Pearls and Pitfalls. 38
31290840 2019
Imaging for Acute and Chronic Scaphoid Fractures. 38
31178083 2019
Volar Radius Vascularized Bone Flaps for the Treatment of Scaphoid Nonunion. 38
31178092 2019
Failed Proximal Humerus Osteosynthesis Using Intramedullary Fibular Strut Allograft Conversion to Reverse Shoulder Arthroplasty. 38
31436758 2019
Ex situ reconstruction of comminuted radial head fractures: is it truly worth a try? 38
31385021 2019
Type IV capitellum fractures in children. 38
31383681 2019
The use of fourth extensor compartment artery bone flap in Kienböck's disease. 38
31291860 2019
Long-term outcomes of total hip arthroplasty in patients younger than 55 years: a systematic review of the contemporary literature 38
31348632 2019
Simultaneous removal of a locking plate and implantation of a reversed shoulder prosthesis in elderly patients suffering from fracture sequelae of the proximal humerus. 38
31414366 2019
Long-term radiographic and clinical-functional outcomes of isolated, displaced, closed talar neck and body fractures treated by ORIF: the timing of surgical management. 38
31391024 2019
Revascularization of the necrotic femoral head after traumatic open anterior hip dislocation in a child: a case report. 38
31416479 2019
Clinical Outcomes of Total Ankle Arthroplasty With Total Talar Prosthesis. 38
31056931 2019
Outcome of 881 total hip arthroplasties in 747 patients 21 years or younger: data from the Nordic Arthroplasty Register Association (NARA) 1995-2016. 38
31088343 2019
The Community Orthopaedic Surgeon Taking Trauma Call: Pediatric Femoral Neck Fracture Pearls and Pitfalls. 38
31290842 2019
Capsulotomy in Unstable Slipped Capital Femoral Epiphysis and the Odds of AVN: A Meta-analysis of Retrospective Studies. 38
30994581 2019
Effect of minimally invasive distal first metatarsal osteotomy on blood flow of the metatarsal head. 38
30583939 2019
Clinical efficacy assessment of cooled radiofrequency ablation of the hip in patients with avascular necrosis. 38
31215846 2019
Hip Arthroscopy as Part of a Salvage Procedure for Avascular Necrosis (AVN) in a 7-Year-Old Child. 38
31263092 2019
Primary medial femoral condyle vascularized bone graft for scaphoid nonunions with carpal collapse and proximal pole avascular necrosis. 38
30049241 2019
Bilateral posterior hip dislocation associated with right Pipkin II fracture: A case report. 38
31352316 2019
Surgical treatment with cannulated screws for pediatric femoral neck fractures: A case series. 38
30770123 2019
Intramedullary nailing of displaced four-part fractures of the proximal humerus. 38
31405519 2019
Patient-reported functional outcomes and health-related quality of life following fractures of the talus. 38
31155885 2019
Impairment of circulating endothelial progenitor cells (EPCs) in patients with glucocorticoid-induced avascular necrosis of the femoral head and changes of EPCs after glucocorticoid treatment in vitro. 38
31324193 2019
10-year results of ReCap hip resurfacing arthroplasty: a non-designer case series. 38
30799642 2019
Effect of Surgeon and Hospital Volume on Complications Following Operative Tarsal Fracture Repair. 38
31356444 2019
Pseudotumor mimicking iliacus muscle abscess following a total hip arthoplasty with metal on metal articulation: A case report. 38
31277178 2019
[Arch-shaped approach : New modified medial approach for the treatment of talus fractures]. 38
31270573 2019
Femoral neck shortening after internal fixation of Garden I fractures increases the risk of femoral head collapse. 38
31320235 2019
Posterior and anterior tilt increases the risk of failure after internal fixation of Garden I and II femoral neck fracture. 38
31269853 2019

Variations for Avascular Necrosis

Expression for Avascular Necrosis

Search GEO for disease gene expression data for Avascular Necrosis.

Pathways for Avascular Necrosis

Pathways related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.95 COL2A1 BMP2

GO Terms for Avascular Necrosis

Cellular components related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 TRPV4 TNFRSF11A BMP2 ABCB1

Biological processes related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cartilage development GO:0051216 9.46 COL2A1 BMP2
2 inner ear development GO:0048839 9.43 COL2A1 BMP2
3 chondrocyte differentiation GO:0002062 9.4 COL2A1 BMP2
4 cellular response to BMP stimulus GO:0071773 9.37 COL2A1 BMP2
5 ossification GO:0001503 9.33 TNFRSF11A COL2A1 BMP2
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.32 SREBF2 BMP2
7 proteoglycan metabolic process GO:0006029 9.26 COL2A1 BMP2
8 cartilage development involved in endochondral bone morphogenesis GO:0060351 8.96 TRPV4 COL2A1
9 regulation of response to osmotic stress GO:0047484 8.62 TRPV4 ABCB1

Sources for Avascular Necrosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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