Avascular Necrosis (AVN)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Avascular Necrosis

MalaCards integrated aliases for Avascular Necrosis:

Name: Avascular Necrosis 58 54
Avn 58


Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases

External Ids:

ICD10 via Orphanet 33 M87.0 M87.1 M87.2 more
Orphanet 58 ORPHA399164

Summaries for Avascular Necrosis

MalaCards based summary : Avascular Necrosis, also known as avn, is related to familial avascular necrosis of the femoral head and osteonecrosis. An important gene associated with Avascular Necrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways is Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related phenotypes are cardiovascular system and hearing/vestibular/ear

Wikipedia : 74 Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

Related Diseases for Avascular Necrosis

Diseases in the Avascular Necrosis family:

Rare Hereditary Disease with Avascular Necrosis Secondary Avascular Necrosis
Primary Avascular Necrosis

Diseases related to Avascular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 308)
# Related Disease Score Top Affiliating Genes
1 familial avascular necrosis of the femoral head 34.4 TRPV4 COL2A1
2 osteonecrosis 32.4 COL2A1 BMP2 ABCB1
3 type ii collagen disorders 29.9 TRPV4 COL2A1
4 skeletal dysplasias 29.9 TRPV4 COL2A1
5 arthropathy 29.8 TRPV4 COL2A1
6 avascular necrosis of femoral head, primary, 1 13.0
7 avascular necrosis of femoral head, primary, 2 12.7
8 idiopathic avascular necrosis 12.6
9 traumatic avascular necrosis 12.6
10 secondary avascular necrosis 12.5
11 primary avascular necrosis 12.5
12 avascular necrosis of genetic origin 12.4
13 secondary non-traumatic avascular necrosis 12.4
14 rare hereditary disease with avascular necrosis 12.4
15 legg-calve-perthes disease 12.3
16 dieterich's disease 11.7
17 kohler's disease 11.7
18 dyskeratosis congenita 11.7
19 osteochondrosis of the metatarsal bone 11.4
20 thiemann disease 11.3
21 arthrogryposis, perthes disease, and upward gaze palsy 11.3
22 dysbaric osteonecrosis 11.3
23 pr interval, variation in 11.2
24 sickle cell disease 10.7
25 systemic lupus erythematosus 10.7
26 lupus erythematosus 10.7
27 slipped capital femoral epiphysis 10.6
28 osteoarthritis 10.6
29 alcohol dependence 10.5
30 lymphocytic leukemia 10.5
31 sickle cell anemia 10.5
32 graft-versus-host disease 10.5
33 leukemia, acute lymphoblastic 10.4
34 gaucher's disease 10.4
35 vasculitis 10.4
36 osteoporosis 10.4
37 bone mineral density quantitative trait locus 8 10.4
38 bone mineral density quantitative trait locus 15 10.4
39 thalassemia 10.4
40 osteochondrosis 10.4
41 hydrops, lactic acidosis, and sideroblastic anemia 10.3
42 osteomyelitis 10.3
43 gout 10.3
44 alcohol use disorder 10.3
45 thrombophilia 10.3
46 antiphospholipid syndrome 10.3
47 septic arthritis 10.3
48 hemoglobinopathy 10.3
49 osteochondritis dissecans 10.3
50 47,xyy 10.3

Graphical network of the top 20 diseases related to Avascular Necrosis:

Diseases related to Avascular Necrosis

Symptoms & Phenotypes for Avascular Necrosis

MGI Mouse Phenotypes related to Avascular Necrosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ABCB1 BMP2 COL2A1 NEK9 TRPV4
2 hearing/vestibular/ear MP:0005377 9.46 ABCB1 BMP2 COL2A1 TRPV4
3 homeostasis/metabolism MP:0005376 9.43 ABCB1 BMP2 COL2A1 NEK9 SREBF2 TRPV4
4 nervous system MP:0003631 9.02 ABCB1 BMP2 COL2A1 SREBF2 TRPV4

Drugs & Therapeutics for Avascular Necrosis

Drugs for Avascular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 265)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Central Nervous System Depressants Phase 4
9 Antioxidants Phase 4
10 Antiemetics Phase 4
11 Gastrointestinal Agents Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Hormone Antagonists Phase 4
14 Autonomic Agents Phase 4
15 Hormones Phase 4
16 Methylprednisolone Acetate Phase 4
17 Neuroprotective Agents Phase 4
18 Protective Agents Phase 4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
leucovorin Approved Phase 3 58-05-9 6006 143
Idarubicin Approved Phase 3 58957-92-9 42890
Daunorubicin Approved Phase 3 20830-81-3 30323
Mercaptopurine Approved Phase 3 50-44-2 667490
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
Pegaspargase Approved, Investigational Phase 3 130167-69-0
Thioguanine Approved Phase 3 154-42-7 2723601
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
Zoledronic Acid Approved Phase 3 118072-93-8 68740
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
Denosumab Approved Phase 3 615258-40-7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
39 Antimetabolites Phase 3
40 Antibiotics, Antitubercular Phase 3
41 Anti-Bacterial Agents Phase 3
42 Calcium, Dietary Phase 3
43 Calciferol Phase 3
44 BB 1101 Phase 3
45 Anti-Infective Agents Phase 3
46 Ibandronic Acid Phase 3
47 Folic Acid Antagonists Phase 3
48 Immunologic Factors Phase 3
49 Vitamin B Complex Phase 3
50 Vitamin B9 Phase 3

Interventional clinical trials:

(show top 50) (show all 126)
# Name Status NCT ID Phase Drugs
1 Randomized, Prospective, Multi-center, Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
2 Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. Completed NCT03368430 Phase 4 Placebo
3 Post Approval Study: NOVATION Ceramic Articulation Hip System A Multi-Center, Open-Label Study to Evaluate the Mid and Long-Term Safety and Effectiveness of the Exactech NOVATION Ceramic Articulation Hip System Recruiting NCT00715143 Phase 4
4 Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery Recruiting NCT03190642 Phase 4 Methylprednisolone
5 Control Study of Implantation of Enriched Bone Marrow Cells for the Treatment of Avascular Necrosis of Femoral Head Unknown status NCT01613612 Phase 2, Phase 3
6 Combined Treatment of Early and Advanced Osteonecrosis of the Femoral Head With Core Decompression and Grafting With Demineralized Bone Matrix (DBM) or Homologous Lyophilized Bone Chips (LBC) Together With Platelet-rich-fibrin (PRF) and Concentrated Bone Marrow (CBM) Unknown status NCT01892514 Phase 3
7 Multicenter, Open-labeled, Randomized Clinical Trial to Determine the Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head Completed NCT00939900 Phase 3 zoledronic acid (aclasta)
8 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
9 Use of the dermaPACE™ (Pulsed Acoustic Cellular Expression) Device in Conjunction With Standard of Care in the Treatment of Diabetic Foot Ulcers Completed NCT00536744 Phase 3
10 Treatment of Patients With Acute Lymphoblastic Leukemia With Unfavorable Features: A Phase III Group-wide Study Completed NCT00002812 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;idarubicin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
11 Efficacy of Denosumab and Zoledronic Acid in the Treatment of Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density: a Prospective Controlled Trial Not yet recruiting NCT04034199 Phase 3 Denosumab;Zoledronic Acid
12 Evaluation of Safety and Feasibility of Bone Marrow Derived Autologous MSCs to Enhance Bone Healing in Patients With Avascular Necrosis of the Femoral Head Unknown status NCT02065167 Phase 2
13 Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease Unknown status NCT02448121 Phase 1, Phase 2
14 Restoration of Muscle Following Hip Surgery Completed NCT00393848 Phase 2 Essential amino acid supplement;Ketoconazole;Placebo
15 Treatment of Osteonecrosis of the Femoral Head by Implantation of Preosteoblastic Cells: a Randomized, Controlled, Single Blind Pilot Study Completed NCT02890537 Phase 2 Core decompression/PREOB® implantation;Core decompression/BMC implantation
16 A Randomized Trial of Interleukin-2 With or Without a Tumor Necrosis Factor Antagonist in Patients With HIV-1 Infection Completed NCT00001475 Phase 2 IL-2 plus Anti-TNF or Thalidomide
17 Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients With Steroid-refractory GVHD- A Phase I/II Clinical Trial Completed NCT02824653 Phase 1, Phase 2
18 A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults With Severe Sickle Cell Disease (BMT CTN #1503) Recruiting NCT02766465 Phase 2 Busulfan;Fludarabine;r-ATG;Tacrolimus;Methotrexate
19 Transcranial Direct Current Stimulation Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease Recruiting NCT02813629 Phase 2
20 A Pilot Clinical Trial of "ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue (XCEL-MT-OSTEO- ALPHA) in Osteonecrosis of the Femoral Head Active, not recruiting NCT01605383 Phase 1, Phase 2
21 AVN Prevention With Lipitor in Lupus Erythematosus APLLE Trial Terminated NCT00412841 Phase 2 Atorvastatin;Placebo
22 A Phase I/IIa Study of the Treatment of None-Infectious Anterior, Intermediate, Posterior and Panuveitis, With the Use of Dexamethasone Delivered by a Iontophoresis Device Withdrawn NCT00499551 Phase 1, Phase 2
23 Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis Withdrawn NCT01932554 Phase 2 Abciximab;Placebo;Ibuprofen;Parenteral narcotic
24 Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation for Human Avascular Necrosis of the Lunate Bone of the Wrist (Kienbock`s Disease) Unknown status NCT02646007 Phase 1
25 Bone Marrow Derived CD133+ Stem Cells Transplantation in Femoral Head Osteonecrosis Completed NCT01198080 Phase 1
26 Evaluation of Endothelial and Hemodynamic Function in HIV Associated Pulmonary Hypertension and a Phase I/II Safety and Efficacy Trial of Sildenafil in HIV Associated Pulmonary Hypertension Terminated NCT00327080 Phase 1 L-NMMA;Acetylcholine
27 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Autografting Unknown status NCT02289976
28 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Auto Grafting Unknown status NCT02291900
29 Femoral Head Resurfacing Versus a Large Femoral Head (Durom®) Total Hip System: A Prospective Randomized Trial Unknown status NCT00175487
30 Porous Tantalum Rods Improve the Hip Joint Function of Patients With Avascular Necrosis of the Femoral Head After Femoral Neck Fracture Surgery: a Randomized Controlled Trial Unknown status NCT02877472
31 Molecular Genetic Study of Avascular Necrosis of the Femoral Head-Revealing ANFH Pathogenesis Mechanism by Cell and Animal Models Unknown status NCT00260897
32 Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up Unknown status NCT00172315
33 Tolerance Induction in Living Donor Kidney Transplantation With Hematopoietic Stem Cell Transplantation Unknown status NCT02199301
34 Feasibility of Implantation of Cemented Femoral Stem in the Treatment of Osteoporotic Femoral Neck Fracture in Elderly Patients: a Randomized Controlled Trial Unknown status NCT02901938
35 Universal Ultrasound-screening for Developmental Dysplasia of the Hip. 5-12 Years Followup of 4 200 Newborns Unknown status NCT01053299
36 Kienbock Disease Radiographic Guided Treatment Versus Arthroscopic Guided Treatment Unknown status NCT03291015
37 Intracapsular Femoral Neck Fractures Fixation With a Dynamic Locking Plate and Screw System, Targon FN. Prospective and Retrospective Cohort Study. Unknown status NCT00830687
38 A Randomized Study of Non-Operative Management Versus Expedited Surgery Among WCB Patients With Small Rotator Cuff Tears: Affect Upon Time to Claim Closure in 2 Prairie Provinces Unknown status NCT01498198
39 Post-operative Oral Corticosteroids Following Tonsillectomy: A Randomized Controlled Trial Unknown status NCT03352115 Prednisolone;Placebos
40 Safety and Efficacy of Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral Head Completed NCT01643655
41 Total Temporomandibular Joint Replacement System Post Approval Study Completed NCT00762944
42 Relations Between Hematologic Variables and Postoperative Bleeding in Total Hip Replacement Arthroplasty Completed NCT01521858
43 Randomized Study of Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease Completed NCT00006130
44 Decellularization of Umbilical Cord Wharton's Jelly for Tissue Regenerative Applications Including Avascular Necrosis Completed NCT01166776
45 Hemostatic Changes After Colloid Fluid Administration During Total Hip Replacement Arthroplasty Completed NCT01512628 Pentaspan, voluven, volulyte
46 Relations Between Hematologic Variables and Postoperative Bleeding and Transfusion in Revision Total Hip Replacement Arthroplasty Completed NCT02951741
47 WEUKBRE5716: Quantifying the Burden of Steroid-related Damage in Systemic Lupus Erythematosus in the Hopkins Lupus Cohort Completed NCT01616472 Cumulative corticosteroid exposure
48 Study Of Pharmacogenetic Risk Factors For Avascular Necrosis CCG 1882 Completed NCT00898469
49 Magnetic Resonance Imaging to Study Avascular Necrosis in HIV-Infected Subjects Completed NCT00001762
50 Cormet Hip Resurfacing System Post-PMA Study Group (New Enrollment) Completed NCT00722007

Search NIH Clinical Center for Avascular Necrosis

Genetic Tests for Avascular Necrosis

Anatomical Context for Avascular Necrosis

MalaCards organs/tissues related to Avascular Necrosis:

Bone, Bone Marrow, Endothelial, Kidney, Liver, Heart, Myeloid

Publications for Avascular Necrosis

Articles related to Avascular Necrosis:

(show top 50) (show all 6198)
# Title Authors PMID Year
Timing of initiation of enzyme replacement therapy after diagnosis of type 1 Gaucher disease: effect on incidence of avascular necrosis. 61 54
19732054 2009
Imiglucerase (Cerezyme) improves quality of life in patients with skeletal manifestations of Gaucher disease. 54 61
17539908 2007
Efficacy and complications after delayed fixation of femoral neck fractures in children. 61
31833450 2020
Acetabular avascular necrosis following high-dose steroid treatment and chemotherapy for leukemia : Computer tomography analysis of treatment with impaction bone grafting. 61
31139921 2020
An alternative fixation method for femoral varus derotational osteotomy in spastic cerebral palsy: the Rush rod. 61
31770291 2020
Blood Flow in the Scaphoid Is Improved by Focused Extracorporeal Shock Wave Therapy. 61
31592777 2020
Correlation between age, gender, and the number of diagnoses of temporomandibular disorders through magnetic resonance imaging: A retrospective observational study. 61
29806568 2020
Treatment for avascular necrosis of bone in people with sickle cell disease. 61
31803937 2019
31841494 2019
HbS/β+ thalassemia: Really a mild disease? A National survey from the AIEOP Sickle Cell Disease Study Group with genotype-phenotype correlation. 61
31788855 2019
Clinical and Genetic Predictors of Priapism in Sickle Cell Disease: Results from the Recipient Epidemiology and Donor Evaluation Study III Brazil Cohort Study. 61
31668730 2019
Comparing the efficacy of Cartiva synthetic cartilage implant hemiarthroplasty vs osteotomy for the treatment of conditions affecting the second metatarsal head. 61
31675598 2019
Analysis of congruence for talar dome geometry among tali of different sizes. 61
31704589 2019
Relationship of Plasminogen Activator Inhibitor 1 4G/5G Gene Polymorphism and Nontraumatic Lunatum Avascular Necrosis. 61
31806394 2019
Incidence, risk factors and outcomes of avascular necrosis occurring after humeral lateral condyle fractures. 61
31821269 2019
The role of vascularized flaps in the treatment of proximal pole avascular necrosis in scaphoid non-unions. 61
31821286 2019
Primary reverse shoulder arthroplasty in patients older than 80 years of age: survival and outcomes. 61
31787000 2019
Total Hip Arthroplasty for Secondary Causes of Arthritis An Increase in Time and Money. 61
31785135 2019
Similar outcome of femoral neck fractures treated with Pinloc or Hansson Pins: 1-year data from a multicenter randomized clinical study on 439 patients. 61
31452431 2019
Comparison of the Effects of Proximal Humeral Internal Locking System (PHILOS) Alone and PHILOS Combined with Fibular Allograft in the Treatment of Neer Three- or Four-part Proximal Humerus Fractures in the Elderly. 61
31762222 2019
Ex situ reconstruction of comminuted radial head fractures: is it truly worth a try? 61
31385021 2019
The scapho-capitate syndrome: a case report with follow-up of three years. 61
31821301 2019
Anteromedial femoral neck plate with cannulated screws for the treatment of irreducible displaced femoral neck fracture in young patients: a preliminary study. 61
29909465 2019
Combined Pedicled Vascularized and Wedge Nonvascularized Bone Graft for Treating Scaphoid Waist Nonunion With Humpback Deformity. 61
31738737 2019
Posterior and anterior tilt increases the risk of failure after internal fixation of Garden I and II femoral neck fracture. 61
31269853 2019
Risk Factors for Intraoperative Periprosthetic Femoral Fractures During Primary Total Hip Arthroplasty. An Analysis From the National Joint Registry for England and Wales and the Isle of Man. 61
31353251 2019
Arthroscopic Treatment of Acute Septic Arthritis of the Hip Joint in Pediatric Patients Aged 10 Years or Younger. 61
31734041 2019
Clinical and Microbiologic Variables Predictive of Orthopedic Complications Following Staphylococcus aureus Acute Hematogenous Osteoarticular Infections in Children. 61
30753346 2019
Femoral osteotomies for the treatment of avascular necrosis of the femoral head. 61
31784775 2019
Posttraumatic Avascular Necrosis After Proximal Femur, Proximal Humerus, Talar Neck, and Scaphoid Fractures. 61
31149969 2019
Osteonecrosis (Avascular Necrosis) of Knee and Tibia. 61
31685230 2019
The effect of robot-navigation-assisted core decompression on early stage osteonecrosis of the femoral head. 61
31752950 2019
Nontraumatic avascular necrosis of the femoral head : Arthroscopic and navigation-supported core decompression. 61
31781806 2019
Functional Outcome of Bell Tawse Procedure for the Management of Chronic Unreduced Monteggia Fracture-Dislocation in Children. 61
31673176 2019
Now you see it: progressive radiographic findings in avascular necrosis of the hip. 61
31789221 2019
Introduction the revolving scarf osteotomy for treating severe hallux valgus with an increased distal metatarsal articular angle: a retrospective cohort study. 61
31679523 2019
Outcome of the modified Dunn procedure in severe chronic or acute on chronic slipped capital femoral epiphysis. 61
31703600 2019
Association Between the Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism and Avascular Necrosis of the Femoral Head. 61
31633405 2019
Vascular bundle transplantation combined with porous bone substituted scaffold for the treatment of early-stage avascular necrosis of femoral head. 61
31454642 2019
Comparison of ceramic-on-ceramic bearing vs ceramic-on-highly cross-linked polyethylene-bearing surfaces in total hip arthroplasty for avascular necrosis of femoral head: a prospective cohort study with a mid-term follow-up. 61
31775827 2019
Intramedullary nailing of displaced four-part fractures of the proximal humerus. 61
31405519 2019
Association of African-American ethnicity and smoking status with total and individual damage index in systemic lupus erythematosus. 61
31705325 2019
Expanding the phenotype of COPA syndrome: a kindred with typical and atypical features. 61
30385646 2019
Riolan arch pseudoaneurysm hemorrhage after endovascular covered stent-graft treatment of an abdominal aortic aneurysm: A case report. 61
31770196 2019
[A review of avascular necrosis, of the hip and beyond]. 61
31722835 2019
Association of IL-6 -174G > C and -572G > C Polymorphisms with Risk of Legg-Calve-Perthes Disease in Iranian Children. 61
31757175 2019
Association between MTHFR 677C>T polymorphism and vascular complications in sickle cell disease: A meta-analysis. 61
30686687 2019
Association between clinical outcomes and metformin use in adults with sickle cell disease and diabetes mellitus. 61
31698459 2019
The Vascular Anatomy of the Scaphoid: New Discoveries Using Micro-Computed Tomography Imaging. 61
31543293 2019
Effect of Surgeon and Hospital Volume on Complications After Operative Tarsal Fracture Repair. 61
31356444 2019

Variations for Avascular Necrosis

Expression for Avascular Necrosis

Search GEO for disease gene expression data for Avascular Necrosis.

Pathways for Avascular Necrosis

Pathways related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.95 COL2A1 BMP2

GO Terms for Avascular Necrosis

Cellular components related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 TRPV4 BMP2 ABCB1

Biological processes related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.46 COL2A1 BMP2
2 cartilage development GO:0051216 9.43 COL2A1 BMP2
3 inner ear development GO:0048839 9.4 COL2A1 BMP2
4 chondrocyte differentiation GO:0002062 9.37 COL2A1 BMP2
5 cellular response to BMP stimulus GO:0071773 9.32 COL2A1 BMP2
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.26 SREBF2 BMP2
7 proteoglycan metabolic process GO:0006029 9.16 COL2A1 BMP2
8 cartilage development involved in endochondral bone morphogenesis GO:0060351 8.96 TRPV4 COL2A1
9 regulation of response to osmotic stress GO:0047484 8.62 TRPV4 ABCB1

Sources for Avascular Necrosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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