AVN
MCID: AVS003
MIFTS: 42

Avascular Necrosis (AVN)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Avascular Necrosis

MalaCards integrated aliases for Avascular Necrosis:

Name: Avascular Necrosis 58 54
Avn 58

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases


External Ids:

ICD10 via Orphanet 33 M87.0 M87.1 M87.2 more
Orphanet 58 ORPHA399164

Summaries for Avascular Necrosis

MalaCards based summary : Avascular Necrosis, also known as avn, is related to familial avascular necrosis of the femoral head and osteonecrosis. An important gene associated with Avascular Necrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway. The drugs Prednisolone phosphate and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and endothelial, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Wikipedia : 74 Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

Related Diseases for Avascular Necrosis

Diseases in the Avascular Necrosis family:

Rare Hereditary Disease with Avascular Necrosis Secondary Avascular Necrosis
Primary Avascular Necrosis

Diseases related to Avascular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 familial avascular necrosis of the femoral head 34.5 TRPV4 COL2A1
2 osteonecrosis 32.8 COL2A1 BMP2 ABCB1
3 osteochondritis dissecans 30.4 COL2A1 BMP2
4 arthropathy 30.1 TRPV4 TNFRSF11A COL2A1
5 type ii collagen disorders 30.1 TRPV4 COL2A1
6 skeletal dysplasias 30.1 TRPV4 COL2A1
7 bone resorption disease 29.7 TNFRSF11A BMP2
8 bone disease 29.7 TNFRSF11A COL2A1 BMP2
9 scoliosis 29.2 TRPV4 TNFRSF11A COL2A1
10 avascular necrosis of femoral head, primary, 1 13.0
11 avascular necrosis of femoral head, primary, 2 12.7
12 idiopathic avascular necrosis 12.6
13 traumatic avascular necrosis 12.6
14 secondary avascular necrosis 12.5
15 primary avascular necrosis 12.5
16 avascular necrosis of genetic origin 12.4
17 secondary non-traumatic avascular necrosis 12.4
18 rare hereditary disease with avascular necrosis 12.4
19 legg-calve-perthes disease 12.3
20 dieterich's disease 11.7
21 kohler's disease 11.7
22 dyskeratosis congenita 11.7
23 osteochondrosis of the metatarsal bone 11.4
24 thiemann disease 11.3
25 arthrogryposis, perthes disease, and upward gaze palsy 11.3
26 dysbaric osteonecrosis 11.3
27 pr interval, variation in 11.3
28 sickle cell disease 10.7
29 systemic lupus erythematosus 10.7
30 lupus erythematosus 10.7
31 developmental dysplasia of the hip 1 10.6
32 slipped capital femoral epiphysis 10.6
33 osteoarthritis 10.6
34 alcohol dependence 10.5
35 sickle cell anemia 10.4
36 graft-versus-host disease 10.4
37 leukemia, acute lymphoblastic 10.4
38 gaucher's disease 10.4
39 vasculitis 10.4
40 osteoporosis 10.4
41 bone mineral density quantitative trait locus 8 10.4
42 bone mineral density quantitative trait locus 15 10.4
43 thalassemia 10.4
44 osteochondrosis 10.4
45 osteomyelitis 10.3
46 gout 10.3
47 alcohol use disorder 10.3
48 antiphospholipid syndrome 10.3
49 thrombophilia 10.3
50 septic arthritis 10.3

Graphical network of the top 20 diseases related to Avascular Necrosis:



Diseases related to Avascular Necrosis

Symptoms & Phenotypes for Avascular Necrosis

MGI Mouse Phenotypes related to Avascular Necrosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 ABCB1 BMP2 COL2A1 TNFRSF11A
2 homeostasis/metabolism MP:0005376 9.5 ABCB1 BMP2 COL2A1 NEK9 SREBF2 TNFRSF11A
3 hearing/vestibular/ear MP:0005377 9.46 ABCB1 BMP2 COL2A1 TRPV4
4 liver/biliary system MP:0005370 8.92 ABCB1 COL2A1 SREBF2 TNFRSF11A

Drugs & Therapeutics for Avascular Necrosis

Drugs for Avascular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 266)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Methylprednisolone Acetate Phase 4
9 Neuroprotective Agents Phase 4
10 Protective Agents Phase 4
11 Antioxidants Phase 4
12
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
13
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
14
leucovorin Approved Phase 3 58-05-9 6006 143
15
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
16
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
17
Pegaspargase Approved, Investigational Phase 3 130167-69-0
18
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
19
Daunorubicin Approved Phase 3 20830-81-3 30323
20
Mercaptopurine Approved Phase 3 50-44-2 667490
21
Thioguanine Approved Phase 3 154-42-7 2723601
22
Idarubicin Approved Phase 3 58957-92-9 42890
23
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
24
Deflazacort Approved, Investigational Phase 2, Phase 3 14484-47-0
25
Zoledronic Acid Approved Phase 3 118072-93-8 68740
26
Denosumab Approved Phase 3 615258-40-7
27
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
28
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
29
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
30 Antimetabolites Phase 3
31 Calcium, Dietary Phase 3
32 Calciferol Phase 3
33 Anti-Infective Agents Phase 3
34 Hormone Antagonists Phase 3
35 Hormones Phase 3
36 Anti-Bacterial Agents Phase 3
37 Antibiotics, Antitubercular Phase 3
38 Ibandronic Acid Phase 3
39 Gastrointestinal Agents Phase 3
40 Vitamin B Complex Phase 3
41 Folic Acid Antagonists Phase 3
42 Folate Phase 3
43 Dermatologic Agents Phase 3
44 Anti-Inflammatory Agents Phase 3
45 Antirheumatic Agents Phase 3
46 Vitamin B9 Phase 3
47 Antineoplastic Agents, Hormonal Phase 3
48 Antiemetics Phase 3
49 Alkylating Agents Phase 3
50
Liposomal doxorubicin Phase 3 31703

Interventional clinical trials:

(show top 50) (show all 133)
# Name Status NCT ID Phase Drugs
1 Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery Unknown status NCT03190642 Phase 4 Methylprednisolone
2 Randomized, Prospective, Multi-center, Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
3 Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. Completed NCT03368430 Phase 4 Placebo
4 Post Approval Study: NOVATION Ceramic Articulation Hip System A Multi-Center, Open-Label Study to Evaluate the Mid and Long-Term Safety and Effectiveness of the Exactech NOVATION Ceramic Articulation Hip System Recruiting NCT00715143 Phase 4
5 Control Study of Implantation of Enriched Bone Marrow Cells for the Treatment of Avascular Necrosis of Femoral Head Unknown status NCT01613612 Phase 2, Phase 3
6 Combined Treatment of Early and Advanced Osteonecrosis of the Femoral Head With Core Decompression and Grafting With Demineralized Bone Matrix (DBM) or Homologous Lyophilized Bone Chips (LBC) Together With Platelet-rich-fibrin (PRF) and Concentrated Bone Marrow (CBM) Unknown status NCT01892514 Phase 3
7 Multicenter, Open-labeled, Randomized Clinical Trial to Determine the Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head Completed NCT00939900 Phase 3 zoledronic acid (aclasta)
8 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
9 Use of the dermaPACE™ (Pulsed Acoustic Cellular Expression) Device in Conjunction With Standard of Care in the Treatment of Diabetic Foot Ulcers Completed NCT00536744 Phase 3
10 Treatment of Patients With Acute Lymphoblastic Leukemia With Unfavorable Features: A Phase III Group-wide Study Completed NCT00002812 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;idarubicin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
11 A Randomized Controlled Trial of Deflazacort vs. Prednisolone in Acute-stage Allergic Bronchopulmonary Aspergillosis Recruiting NCT04227483 Phase 2, Phase 3 Deflazacort;Prednisolone
12 Efficacy of Denosumab and Zoledronic Acid in the Treatment of Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density: a Prospective Controlled Trial Not yet recruiting NCT04034199 Phase 3 Denosumab;Zoledronic Acid
13 Evaluation of Safety and Feasibility of Bone Marrow Derived Autologous MSCs to Enhance Bone Healing in Patients With Avascular Necrosis of the Femoral Head Unknown status NCT02065167 Phase 2
14 Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease Unknown status NCT02448121 Phase 1, Phase 2
15 A Pilot Clinical Trial of "ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue (XCEL-MT-OSTEO- ALPHA) in Osteonecrosis of the Femoral Head Completed NCT01605383 Phase 1, Phase 2
16 Restoration of Muscle Following Hip Surgery Completed NCT00393848 Phase 2 Essential amino acid supplement;Ketoconazole;Placebo
17 Treatment of Osteonecrosis of the Femoral Head by Implantation of Preosteoblastic Cells: a Randomized, Controlled, Single Blind Pilot Study Completed NCT02890537 Phase 2 Core decompression/PREOB® implantation;Core decompression/BMC implantation
18 A Randomized Trial of Interleukin-2 With or Without a Tumor Necrosis Factor Antagonist in Patients With HIV-1 Infection Completed NCT00001475 Phase 2 IL-2 plus Anti-TNF or Thalidomide
19 Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients With Steroid-refractory GVHD- A Phase I/II Clinical Trial Completed NCT02824653 Phase 1, Phase 2
20 A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults With Severe Sickle Cell Disease (BMT CTN #1503) Recruiting NCT02766465 Phase 2 Busulfan;Fludarabine;r-ATG;Tacrolimus;Methotrexate;Alemtuzumab;Total Body Irradiation (TBI);Sirolimus;Melphalan;G-CSF
21 Transcranial Direct Current Stimulation Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease Recruiting NCT02813629 Phase 2
22 AVN Prevention With Lipitor in Lupus Erythematosus APLLE Trial Terminated NCT00412841 Phase 2 Atorvastatin;Placebo
23 Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis Withdrawn NCT01932554 Phase 2 Abciximab;Placebo;Ibuprofen;Parenteral narcotic
24 A Phase I/IIa Study of the Treatment of None-Infectious Anterior, Intermediate, Posterior and Panuveitis, With the Use of Dexamethasone Delivered by a Iontophoresis Device Withdrawn NCT00499551 Phase 1, Phase 2
25 Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation for Human Avascular Necrosis of the Lunate Bone of the Wrist (Kienbock`s Disease) Unknown status NCT02646007 Phase 1
26 Bone Marrow Derived CD133+ Stem Cells Transplantation in Femoral Head Osteonecrosis Completed NCT01198080 Phase 1
27 Evaluation of Endothelial and Hemodynamic Function in HIV Associated Pulmonary Hypertension and a Phase I/II Safety and Efficacy Trial of Sildenafil in HIV Associated Pulmonary Hypertension Terminated NCT00327080 Phase 1 L-NMMA;Acetylcholine
28 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Autografting Unknown status NCT02289976
29 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Auto Grafting Unknown status NCT02291900
30 Femoral Head Resurfacing Versus a Large Femoral Head (Durom®) Total Hip System: A Prospective Randomized Trial Unknown status NCT00175487
31 Porous Tantalum Rods Improve the Hip Joint Function of Patients With Avascular Necrosis of the Femoral Head After Femoral Neck Fracture Surgery: a Randomized Controlled Trial Unknown status NCT02877472
32 Molecular Genetic Study of Avascular Necrosis of the Femoral Head-Revealing ANFH Pathogenesis Mechanism by Cell and Animal Models Unknown status NCT00260897
33 the Fixation Method for the Treatment of Femoral Neck Fractures Unknown status NCT03550079
34 Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up Unknown status NCT00172315
35 Feasibility of Implantation of Cemented Femoral Stem in the Treatment of Osteoporotic Femoral Neck Fracture in Elderly Patients: a Randomized Controlled Trial Unknown status NCT02901938
36 Tolerance Induction in Living Donor Kidney Transplantation With Hematopoietic Stem Cell Transplantation Unknown status NCT02199301
37 Universal Ultrasound-screening for Developmental Dysplasia of the Hip. 5-12 Years Followup of 4 200 Newborns Unknown status NCT01053299
38 Prospective Randomized Study to Compare Clinical Outcomes in Patients With Osteomyelitis Treated With Intravenous Antibiotics Versus Intravenous Antibiotics With an Early Switch to Oral Antibiotics Unknown status NCT02099240 Early Phase 1 oral antibiotics
39 Intracapsular Femoral Neck Fractures Fixation With a Dynamic Locking Plate and Screw System, Targon FN. Prospective and Retrospective Cohort Study. Unknown status NCT00830687
40 Kienbock Disease Radiographic Guided Treatment Versus Arthroscopic Guided Treatment Unknown status NCT03291015
41 A Randomized Study of Non-Operative Management Versus Expedited Surgery Among WCB Patients With Small Rotator Cuff Tears: Affect Upon Time to Claim Closure in 2 Prairie Provinces Unknown status NCT01498198
42 Post-operative Oral Corticosteroids Following Tonsillectomy: A Randomized Controlled Trial Unknown status NCT03352115 Prednisolone;Placebos
43 Safety and Efficacy of Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral Head Completed NCT01643655
44 Core Decompression With Bone Chips Allograft Adjuvanted by Fibrin Platelet Rich-plasma (PRP) and Concentrated Autologous Mesenchymal Stromal Cells (MSCS): Results in Avascular Necrosis of Femoral Head (AVN) After 2 Years Minimum Follow-up Completed NCT04210440
45 Total Temporomandibular Joint Replacement System Post Approval Study Completed NCT00762944
46 Relations Between Hematologic Variables and Postoperative Bleeding in Total Hip Replacement Arthroplasty Completed NCT01521858
47 Randomized Study of Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease Completed NCT00006130
48 Decellularization of Umbilical Cord Wharton's Jelly for Tissue Regenerative Applications Including Avascular Necrosis Completed NCT01166776
49 Hemostatic Changes After Colloid Fluid Administration During Total Hip Replacement Arthroplasty Completed NCT01512628 Pentaspan, voluven, volulyte
50 Relations Between Hematologic Variables and Postoperative Bleeding and Transfusion in Revision Total Hip Replacement Arthroplasty Completed NCT02951741

Search NIH Clinical Center for Avascular Necrosis

Genetic Tests for Avascular Necrosis

Anatomical Context for Avascular Necrosis

MalaCards organs/tissues related to Avascular Necrosis:

40
Bone, Bone Marrow, Endothelial, Kidney, Liver, Myeloid, Heart

Publications for Avascular Necrosis

Articles related to Avascular Necrosis:

(show top 50) (show all 6346)
# Title Authors PMID Year
1
Timing of initiation of enzyme replacement therapy after diagnosis of type 1 Gaucher disease: effect on incidence of avascular necrosis. 61 54
19732054 2009
2
Imiglucerase (Cerezyme) improves quality of life in patients with skeletal manifestations of Gaucher disease. 61 54
17539908 2007
3
Does the timing of treatment affect complications of pediatric femoral neck fractures? 61
32425419 2020
4
Transphyseal Humeral Separations: What Can We Learn? A Retrospective, Multicenter Review of Surgically Treated Patients Over a 25-Year Period. 61
32501903 2020
5
Bone marrow edema around the hip in non-traumatic pain: dual-energy CT vs MRI. 61
32166490 2020
6
Surgical hip dislocation with femoral osteotomy and bone grafting prevents head collapse in hips with advanced necrosis. 61
31204506 2020
7
A cross sectional study of outcomes of muscle pedicle grafting in neck of femur fractures and avascular necrosis of femoral head. 61
32409186 2020
8
Comparison of core decompression and porous tantalum rod implantation with conservative treatment for avascular necrosis of the femoral head: A minimum 18 month follow-up study. 61
32509016 2020
9
Does Adductor Tenotomy Need During Closed Reduction Have a Prognostic Value in the Treatment of Developmental Dysplasia of the Hip Between 6 and 12 Months of Age? "Adductor Tenotomy in the Treatment of Developmental Dysplasia''. 61
32549964 2020
10
Efficacy of total hip arthroplasty after operatively treated acetabular fracture. 61
32296966 2020
11
Transient Familial Factor V Leiden-Linked Hip Osteoporosis. 61
32229104 2020
12
Variables Associated With Lag Screw Sliding After Single-Screw Cephalomedullary Nail Fixation of Intertrochanteric Fractures. 61
31917758 2020
13
Risk factors associated with unsatisfactory hip function in children with late-diagnosed developmental dislocation of the hip treated by open reduction. 61
32571742 2020
14
Surgical tips and tricks for coronal shear fractures of the elbow. 61
32495117 2020
15
Open reduction and internal fixation of three- and four-part proximal humeral fractures by intrafocal distraction: a clinical and radiographic study of thirty-two cases with five to ten years of follow-up. 61
32564175 2020
16
Early Radiographic Union Score for Hip Is Predictive of Femoral Neck Fracture Complications Within 2 Years. 61
31809418 2020
17
Fibula allograft propping as an effective treatment for early-stage osteonecrosis of the femoral head: a systematic review. 61
32493388 2020
18
Abdominal Manifestations of Sickle Cell Disease. 61
32564896 2020
19
Ankle Arthrodesis With Anterior Plate Fixation in Patients at High Risk for Nonunion. 61
31113259 2020
20
Distal chevron osteotomy with lateral release for moderate to severe hallux valgus patients aged sixty years and over. 61
32322942 2020
21
Letter regarding "Popere et al. A cross sectional study of outcomes of muscle pedicle grafting in neck of femur fractures and avascular necrosis of femoral head. Injury.2020. Doi.org/10.1016/j.injury.2020.04.026. 61
32571551 2020
22
Medial Femoral Condyle Periosteal Free Flap for the Treatment of Talus Avascular Necrosis. 61
32326752 2020
23
Avascular necrosis in cleft maxillary repositioning: a review of cases and introduction of the 'delayed maxillary flap'. 61
32505338 2020
24
Outcome after the surgical treatment of the Dubberley type B distal humeral capitellar and trochlear fractures with a buttress plate. 61
32554364 2020
25
[Bone remodeling after total hip arthroplasty with anatomic medullary locking prosthesis and its long-term effectiveness]. 61
32538557 2020
26
Tübingen hip flexion splints for developmental dysplasia of the hip in infants aged 0-6 months. 61
32503452 2020
27
Early Experience of Direct Anterior Approach Total Hip Arthroplasty: Analysis of the First 53 Cases. 61
32566538 2020
28
Angular stable plate versus reverse shoulder arthroplasty for proximal humeral fractures in elderly patient. 61
32504451 2020
29
Surgical Approach and Internal Fixation Techniques for Intra-Articular Distal Humerus Fracture With Coronal Shear Capitellar Fracture. 61
32520775 2020
30
Pelvic and acetabular fracture management in intravenous drug users. 61
32507948 2020
31
Complications after surgical management of proximal humeral fractures: a systematic review of event terms and definitions. 61
32456631 2020
32
Safety of shoulder arthroplasty in lung transplant recipients. 61
32451618 2020
33
Quantitative Characterization of Bone Viability of Femoral Head and Subchondral Bone by Using Single Photon Emission Computerized Tomography/Computerized Tomography (SPECT/CT). 61
32430492 2020
34
Mites and ticks of reptiles and amphibians in Brazil. 61
32407792 2020
35
Streamlining Definitive Care for Occult Scaphoid Fractures: A Retrospective Review of the Workup of Scaphoid Nonunions and Applying Lessons Learned. 61
32400856 2020
36
Tumours of the talus - A pictorial review. 61
32405200 2020
37
Pathology Assessment of Femoral Head Resection Specimens: An Important Quality Assurance Procedure. 61
31538796 2020
38
Arthroscopic Synovectomy and Excision of a Sesamoid in the Management of an Atypical Presentation of Avascular Necrosis of Bone: A Case Report. 61
32354515 2020
39
Avascular Necrosis of the Hip in Primary Care. 61
32447880 2020
40
[Evaluation of multimodal analgesia in treatment of avascular necrosis of femoral head with free vascularized fibular grafting]. 61
32410424 2020
41
Medications in COVID-19 patients: summarizing the current literature from an orthopaedic perspective. 61
32445030 2020
42
Relationship of Plasminogen Activator Inhibitor 1 4G/5G Gene Polymorphism and Nontraumatic Lunatum Avascular Necrosis. 61
31806394 2020
43
Idiopathic Avascular Necrosis of Trapezoid in Adolescence: 3-Year Follow-Up. 61
30733102 2020
44
Tibiotalocalcaneal nail failure in a 60-year-old male: Case report and surgical technique. 61
32405215 2020
45
MiR-379 relieves myocardial injury after acute myocardial infarction by regulating tumor necrosis factor-α-induced protein 8. 61
32414226 2020
46
Osteochondroses of the bilateral metacarpal heads: Dieterich disease. A case report with review of the literature. 61
32497998 2020
47
[Anatomy of pisiform blood supply and feasibility of vascularized pisiform transfer for avascular necrosis of lunate based on digital technique]. 61
32410427 2020
48
The Effect of Proximal Hamate Osteotomy on Carpal Kinematics for Reconstruction of Proximal Pole Scaphoid Nonunion With Avascular Necrosis. 61
30124083 2020
49
Longtime Outcome After Intraosseous Application of Autologous Mesenchymal Stromal Cells in Pediatric Patients and Young Adults with Avascular Necrosis After Steroid or Chemotherapy. 61
32295491 2020
50
TNF-α regulates the early development of avascular necrosis of the femoral head by mediating osteoblast autophagy and apoptosis via the p38 MAPK/NF-κB signaling pathway. 61
32437045 2020

Variations for Avascular Necrosis

Expression for Avascular Necrosis

Search GEO for disease gene expression data for Avascular Necrosis.

Pathways for Avascular Necrosis

Pathways related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.93 COL2A1 BMP2
2 9.95 COL2A1 BMP2

GO Terms for Avascular Necrosis

Cellular components related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 TRPV4 TNFRSF11A BMP2 ABCB1

Biological processes related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cartilage development GO:0051216 9.46 COL2A1 BMP2
2 inner ear development GO:0048839 9.43 COL2A1 BMP2
3 ossification GO:0001503 9.43 TNFRSF11A COL2A1 BMP2
4 chondrocyte differentiation GO:0002062 9.4 COL2A1 BMP2
5 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.37 SREBF2 BMP2
6 cellular response to BMP stimulus GO:0071773 9.32 COL2A1 BMP2
7 proteoglycan metabolic process GO:0006029 9.16 COL2A1 BMP2
8 cartilage development involved in endochondral bone morphogenesis GO:0060351 8.96 TRPV4 COL2A1
9 regulation of response to osmotic stress GO:0047484 8.62 TRPV4 ABCB1

Sources for Avascular Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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