Avascular Necrosis (AVN)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Avascular Necrosis

MalaCards integrated aliases for Avascular Necrosis:

Name: Avascular Necrosis 58 54
Avn 58


Orphanet: 58  
Rare systemic and rhumatological diseases
Rare bone diseases

External Ids:

ICD10 via Orphanet 33 M87.0 M87.1 M87.2 more
Orphanet 58 ORPHA399164

Summaries for Avascular Necrosis

MalaCards based summary : Avascular Necrosis, also known as avn, is related to familial avascular necrosis of the femoral head and osteonecrosis. An important gene associated with Avascular Necrosis is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways is Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney, and related phenotypes are cardiovascular system and hearing/vestibular/ear

Wikipedia : 74 Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to... more...

Related Diseases for Avascular Necrosis

Diseases in the Avascular Necrosis family:

Rare Hereditary Disease with Avascular Necrosis Secondary Avascular Necrosis
Primary Avascular Necrosis

Diseases related to Avascular Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 317)
# Related Disease Score Top Affiliating Genes
1 familial avascular necrosis of the femoral head 34.4 TRPV4 COL2A1
2 osteonecrosis 32.4 COL2A1 BMP2 ABCB1
3 type ii collagen disorders 29.9 TRPV4 COL2A1
4 skeletal dysplasias 29.9 TRPV4 COL2A1
5 arthropathy 29.8 TRPV4 COL2A1
6 avascular necrosis of femoral head, primary, 1 13.0
7 avascular necrosis of femoral head, primary, 2 12.7
8 idiopathic avascular necrosis 12.6
9 traumatic avascular necrosis 12.6
10 secondary avascular necrosis 12.5
11 primary avascular necrosis 12.5
12 avascular necrosis of genetic origin 12.4
13 secondary non-traumatic avascular necrosis 12.4
14 rare hereditary disease with avascular necrosis 12.4
15 legg-calve-perthes disease 12.3
16 dieterich's disease 11.7
17 kohler's disease 11.7
18 dyskeratosis congenita 11.7
19 osteochondrosis of the metatarsal bone 11.4
20 thiemann disease 11.3
21 arthrogryposis, perthes disease, and upward gaze palsy 11.3
22 dysbaric osteonecrosis 11.3
23 pr interval, variation in 11.2
24 sickle cell disease 10.7
25 systemic lupus erythematosus 10.7
26 lupus erythematosus 10.7
27 slipped capital femoral epiphysis 10.6
28 osteoarthritis 10.6
29 alcohol dependence 10.5
30 lymphocytic leukemia 10.5
31 sickle cell anemia 10.4
32 graft-versus-host disease 10.4
33 leukemia, acute lymphoblastic 10.4
34 gaucher's disease 10.4
35 vasculitis 10.4
36 osteoporosis 10.4
37 bone mineral density quantitative trait locus 8 10.4
38 bone mineral density quantitative trait locus 15 10.4
39 thalassemia 10.4
40 osteochondrosis 10.4
41 hydrops, lactic acidosis, and sideroblastic anemia 10.3
42 osteomyelitis 10.3
43 gout 10.3
44 alcohol use disorder 10.3
45 antiphospholipid syndrome 10.3
46 thrombophilia 10.3
47 septic arthritis 10.3
48 bunion 10.3
49 hemoglobinopathy 10.3
50 osteochondritis dissecans 10.3

Graphical network of the top 20 diseases related to Avascular Necrosis:

Diseases related to Avascular Necrosis

Symptoms & Phenotypes for Avascular Necrosis

MGI Mouse Phenotypes related to Avascular Necrosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ABCB1 BMP2 COL2A1 NEK9 TRPV4
2 hearing/vestibular/ear MP:0005377 9.46 ABCB1 BMP2 COL2A1 TRPV4
3 homeostasis/metabolism MP:0005376 9.43 ABCB1 BMP2 COL2A1 NEK9 SREBF2 TRPV4
4 nervous system MP:0003631 9.02 ABCB1 BMP2 COL2A1 SREBF2 TRPV4

Drugs & Therapeutics for Avascular Necrosis

Drugs for Avascular Necrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 267)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Central Nervous System Depressants Phase 4
9 Antioxidants Phase 4
10 Hormone Antagonists Phase 4
11 Hormones Phase 4
12 Antiemetics Phase 4
13 Gastrointestinal Agents Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Autonomic Agents Phase 4
16 Antineoplastic Agents, Hormonal Phase 4
17 Methylprednisolone Acetate Phase 4
18 Neuroprotective Agents Phase 4
19 Protective Agents Phase 4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
leucovorin Approved Phase 3 58-05-9 6006 143
Daunorubicin Approved Phase 3 20830-81-3 30323
Idarubicin Approved Phase 3 58957-92-9 42890
Mercaptopurine Approved Phase 3 50-44-2 667490
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
Thioguanine Approved Phase 3 154-42-7 2723601
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
Pegaspargase Approved, Investigational Phase 3 130167-69-0
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
Zoledronic Acid Approved Phase 3 118072-93-8 68740
Denosumab Approved Phase 3 615258-40-7
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
40 Antimetabolites Phase 3
41 Antibiotics, Antitubercular Phase 3
42 Anti-Bacterial Agents Phase 3
43 Calcium, Dietary Phase 3
44 Calciferol Phase 3
45 Anti-Infective Agents Phase 3
46 BB 1101 Phase 3
47 Ibandronic Acid Phase 3
48 Immunologic Factors Phase 3
49 Alkylating Agents Phase 3
50 Folic Acid Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 126)
# Name Status NCT ID Phase Drugs
1 Randomized, Prospective, Multi-center, Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
2 Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. Completed NCT03368430 Phase 4 Placebo
3 Post Approval Study: NOVATION Ceramic Articulation Hip System A Multi-Center, Open-Label Study to Evaluate the Mid and Long-Term Safety and Effectiveness of the Exactech NOVATION Ceramic Articulation Hip System Recruiting NCT00715143 Phase 4
4 Prospective Evaluation of Perioperative Steroid Dosing on Postsurgical Edema in Orthognathic Surgery Recruiting NCT03190642 Phase 4 Methylprednisolone
5 Control Study of Implantation of Enriched Bone Marrow Cells for the Treatment of Avascular Necrosis of Femoral Head Unknown status NCT01613612 Phase 2, Phase 3
6 Combined Treatment of Early and Advanced Osteonecrosis of the Femoral Head With Core Decompression and Grafting With Demineralized Bone Matrix (DBM) or Homologous Lyophilized Bone Chips (LBC) Together With Platelet-rich-fibrin (PRF) and Concentrated Bone Marrow (CBM) Unknown status NCT01892514 Phase 3
7 Multicenter, Open-labeled, Randomized Clinical Trial to Determine the Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head Completed NCT00939900 Phase 3 zoledronic acid (aclasta)
8 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
9 Use of the dermaPACE™ (Pulsed Acoustic Cellular Expression) Device in Conjunction With Standard of Care in the Treatment of Diabetic Foot Ulcers Completed NCT00536744 Phase 3
10 Treatment of Patients With Acute Lymphoblastic Leukemia With Unfavorable Features: A Phase III Group-wide Study Completed NCT00002812 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;idarubicin;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
11 Efficacy of Denosumab and Zoledronic Acid in the Treatment of Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density: a Prospective Controlled Trial Not yet recruiting NCT04034199 Phase 3 Denosumab;Zoledronic Acid
12 Evaluation of Safety and Feasibility of Bone Marrow Derived Autologous MSCs to Enhance Bone Healing in Patients With Avascular Necrosis of the Femoral Head Unknown status NCT02065167 Phase 2
13 Treatment for Hip, Knee, Ankle and Shoulder Osteonecrosis With Autologous Mononuclear Cells Transplantation in People With Sickle Cell Disease Unknown status NCT02448121 Phase 1, Phase 2
14 Restoration of Muscle Following Hip Surgery Completed NCT00393848 Phase 2 Essential amino acid supplement;Ketoconazole;Placebo
15 Treatment of Osteonecrosis of the Femoral Head by Implantation of Preosteoblastic Cells: a Randomized, Controlled, Single Blind Pilot Study Completed NCT02890537 Phase 2 Core decompression/PREOB® implantation;Core decompression/BMC implantation
16 A Randomized Trial of Interleukin-2 With or Without a Tumor Necrosis Factor Antagonist in Patients With HIV-1 Infection Completed NCT00001475 Phase 2 IL-2 plus Anti-TNF or Thalidomide
17 Allogenic Bone Marrow Mesenchymal Stem Cells Infusion in Patients With Steroid-refractory GVHD- A Phase I/II Clinical Trial Completed NCT02824653 Phase 1, Phase 2
18 A Study to Compare Bone Marrow Transplantation to Standard Care in Adolescents and Young Adults With Severe Sickle Cell Disease (BMT CTN #1503) Recruiting NCT02766465 Phase 2 Busulfan;Fludarabine;r-ATG;Tacrolimus;Methotrexate
19 Transcranial Direct Current Stimulation Associated With Peripheral Electrical Stimulation for Pain Control in Individuals With Sickle Cell Disease Recruiting NCT02813629 Phase 2
20 A Pilot Clinical Trial of "ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue (XCEL-MT-OSTEO- ALPHA) in Osteonecrosis of the Femoral Head Active, not recruiting NCT01605383 Phase 1, Phase 2
21 AVN Prevention With Lipitor in Lupus Erythematosus APLLE Trial Terminated NCT00412841 Phase 2 Atorvastatin;Placebo
22 A Phase I/IIa Study of the Treatment of None-Infectious Anterior, Intermediate, Posterior and Panuveitis, With the Use of Dexamethasone Delivered by a Iontophoresis Device Withdrawn NCT00499551 Phase 1, Phase 2
23 Abciximab (ReoPro) as a Therapeutic Intervention for Sickle Cell Vaso-Occlusive Pain Crisis Withdrawn NCT01932554 Phase 2 Abciximab;Placebo;Ibuprofen;Parenteral narcotic
24 Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation for Human Avascular Necrosis of the Lunate Bone of the Wrist (Kienbock`s Disease) Unknown status NCT02646007 Phase 1
25 Bone Marrow Derived CD133+ Stem Cells Transplantation in Femoral Head Osteonecrosis Completed NCT01198080 Phase 1
26 Evaluation of Endothelial and Hemodynamic Function in HIV Associated Pulmonary Hypertension and a Phase I/II Safety and Efficacy Trial of Sildenafil in HIV Associated Pulmonary Hypertension Terminated NCT00327080 Phase 1 L-NMMA;Acetylcholine
27 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Autografting Unknown status NCT02289976
28 Talar Avascular Necrosis: Surgical Angiogenesis Compared to Core Decompression With Osseous Auto Grafting Unknown status NCT02291900
29 Femoral Head Resurfacing Versus a Large Femoral Head (Durom®) Total Hip System: A Prospective Randomized Trial Unknown status NCT00175487
30 Porous Tantalum Rods Improve the Hip Joint Function of Patients With Avascular Necrosis of the Femoral Head After Femoral Neck Fracture Surgery: a Randomized Controlled Trial Unknown status NCT02877472
31 Molecular Genetic Study of Avascular Necrosis of the Femoral Head-Revealing ANFH Pathogenesis Mechanism by Cell and Animal Models Unknown status NCT00260897
32 Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up Unknown status NCT00172315
33 Feasibility of Implantation of Cemented Femoral Stem in the Treatment of Osteoporotic Femoral Neck Fracture in Elderly Patients: a Randomized Controlled Trial Unknown status NCT02901938
34 Tolerance Induction in Living Donor Kidney Transplantation With Hematopoietic Stem Cell Transplantation Unknown status NCT02199301
35 Universal Ultrasound-screening for Developmental Dysplasia of the Hip. 5-12 Years Followup of 4 200 Newborns Unknown status NCT01053299
36 Intracapsular Femoral Neck Fractures Fixation With a Dynamic Locking Plate and Screw System, Targon FN. Prospective and Retrospective Cohort Study. Unknown status NCT00830687
37 Kienbock Disease Radiographic Guided Treatment Versus Arthroscopic Guided Treatment Unknown status NCT03291015
38 A Randomized Study of Non-Operative Management Versus Expedited Surgery Among WCB Patients With Small Rotator Cuff Tears: Affect Upon Time to Claim Closure in 2 Prairie Provinces Unknown status NCT01498198
39 Post-operative Oral Corticosteroids Following Tonsillectomy: A Randomized Controlled Trial Unknown status NCT03352115 Prednisolone;Placebos
40 Safety and Efficacy of Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral Head Completed NCT01643655
41 Relations Between Hematologic Variables and Postoperative Bleeding in Total Hip Replacement Arthroplasty Completed NCT01521858
42 Total Temporomandibular Joint Replacement System Post Approval Study Completed NCT00762944
43 Randomized Study of Decompression Coring Versus Conservative Therapy in Patients With Avascular Necrosis of the Hip Related to Sickle Cell Disease Completed NCT00006130
44 Decellularization of Umbilical Cord Wharton's Jelly for Tissue Regenerative Applications Including Avascular Necrosis Completed NCT01166776
45 Hemostatic Changes After Colloid Fluid Administration During Total Hip Replacement Arthroplasty Completed NCT01512628 Pentaspan, voluven, volulyte
46 Relations Between Hematologic Variables and Postoperative Bleeding and Transfusion in Revision Total Hip Replacement Arthroplasty Completed NCT02951741
47 Study Of Pharmacogenetic Risk Factors For Avascular Necrosis CCG 1882 Completed NCT00898469
48 WEUKBRE5716: Quantifying the Burden of Steroid-related Damage in Systemic Lupus Erythematosus in the Hopkins Lupus Cohort Completed NCT01616472 Cumulative corticosteroid exposure
49 Magnetic Resonance Imaging to Study Avascular Necrosis in HIV-Infected Subjects Completed NCT00001762
50 Clinical Analysis of Two Methods for Closed Reduction of Developmental Dislocation of the Hip by Prolonged Traction < 6 Months----An Multicenter Prospective Observational Study Completed NCT03096470

Search NIH Clinical Center for Avascular Necrosis

Genetic Tests for Avascular Necrosis

Anatomical Context for Avascular Necrosis

MalaCards organs/tissues related to Avascular Necrosis:

Bone, Bone Marrow, Kidney, Liver, Endothelial, Myeloid, Pituitary

Publications for Avascular Necrosis

Articles related to Avascular Necrosis:

(show top 50) (show all 6230)
# Title Authors PMID Year
Timing of initiation of enzyme replacement therapy after diagnosis of type 1 Gaucher disease: effect on incidence of avascular necrosis. 54 61
19732054 2009
Imiglucerase (Cerezyme) improves quality of life in patients with skeletal manifestations of Gaucher disease. 54 61
17539908 2007
Complications after Metatarsal Osteotomies for Hallux Valgus: Malunion, Nonunion, Avascular Necrosis, and Metatarsophalangeal Osteoarthritis. 61
31997743 2020
Management of Complications After Hallux Valgus Reconstruction. 61
31997742 2020
Incidence, risk factors and outcomes of avascular necrosis occurring after humeral lateral condyle fractures. 61
31821269 2020
Safety of Arthroscopic Versus Open or Combined Heterotopic Ossification Removal Around the Elbow. 61
31870750 2020
Avascular necrosis of the femoral head after single steroid intra-articular injection. 61
31538269 2020
Arthroscopic Treatment of Acute Septic Arthritis of the Hip Joint in Pediatric Patients Aged 10 Years or Younger. 61
31734041 2020
Avascular Necrosis of the Carpal Bones Other Than Kienböck Disease. 61
31585747 2020
LncRNA-MALAT1 promotes osteogenic differentiation through regulating ATF4 by sponging miR-214: Implication of steroid-induced avascular necrosis of the femoral head. 61
31678133 2020
Intraoperative Contrast-Enhanced Ultrasound Imaging of Femoral Head Perfusion in Developmental Dysplasia of the Hip: A Feasibility Study. 61
31334874 2020
The effect of bone morphogenetic protein 2 composite materials combined with cannulated screws in treatment of acute displaced femoral neck fractures. 61
32028406 2020
Navicular Body Fractures-Surgical Treatment and Radiographic Results. 61
31939779 2020
Long-term outcomes of distal humeral epiphyseal separations treated via closed reduction and pinning under arthrogram. 61
31787331 2020
Association of African-American ethnicity and smoking status with total and individual damage index in systemic lupus erythematosus. 61
31705325 2020
Efficacy and complications after delayed fixation of femoral neck fractures in children. 61
31833450 2020
Influence of MicroRNA-141 on Inhibition of the Proliferation of Bone Marrow Mesenchymal Stem Cells in Steroid-Induced Osteonecrosis via SOX11. 61
31916393 2020
Degeneration of three or more lumbar discs significantly decreases lumbar spine/hip ROM ratio during position change from standing to sitting in AVN patients before THA. 61
31954404 2020
Partial Humeral Head Resurfacing for Avascular Necrosis. 61
32021794 2020
Avascular Necrosis and Bone Infarcts of the Knee. 61
31977744 2020
Avascular Necrosis and Bone Infarcts of the Knee. 61
31977745 2020
Evaluating the association between avascular necrosis of femoral head and oral corticosteroids use in Taiwan. 61
32011437 2020
[Hip preservation experience of avascular necrosis of femoral head according to China-Japan Friendship Hospital classification]. 61
31939227 2020
Avascular necrosis of the femoral head: Assessment following developmental dysplasia of the hip management. 61
31983917 2020
Initial displacement as a risk factor for avascular necrosis of the femoral head in pediatric femoral neck fractures: a review of one hundred eight cases. 61
31655884 2020
Correlation between age, gender, and the number of diagnoses of temporomandibular disorders through magnetic resonance imaging: A retrospective observational study. 61
29806568 2020
Autologous Osteoligamentous Reconstruction of Scaphoid Proximal Pole With Metatarsal Head and Collateral Ligament: Cadaver Anatomic Description of Novel Surgical Technique. 61
31965865 2020
Evaluation for Kienböck Disease Familial Clustering: A Population-Based Cohort Study. 61
31761504 2020
Surgical Treatment of Talar Neck and Body Fractures: Mid-Term Results of 24 Cases. 61
31918443 2020
Protective effect of Agrimonia pilosa polysaccharides on dexamethasone-treated MC3T3-E1 cells via Wnt/β-Catenin pathway. 61
31957180 2020
Early locking plate removal following open reduction and internal fixation of proximal humeral fractures could prevent secondary implant-related complications. 61
31879485 2020
Variables Associated With Lag Screw Sliding After Single-Screw Cephalomedullary Nail Fixation of Intertrochanteric Fractures. 61
31917758 2020
Transfer of osteochondral shell autografts to salvage femoral head impaction injuries in hip trauma patients. 61
32033805 2020
Blood Flow in the Scaphoid Is Improved by Focused Extracorporeal Shock Wave Therapy. 61
31592777 2020
Avascular necrosis less frequently found in systemic lupus erythematosus patients with the use of alternate day corticosteroid. 61
31905492 2020
Hip preserving surgery for avascular hip necrosis: does terminating exposure to known risk factors improve survival? 61
31914339 2020
[A review of avascular necrosis, of the hip and beyond]. 61
31722835 2020
Natural History of Treated Subarachnoid Neurocysticercosis. 61
31642423 2020
Acetabular avascular necrosis following high-dose steroid treatment and chemotherapy for leukemia : Computer tomography analysis of treatment with impaction bone grafting. 61
31139921 2020
An alternative fixation method for femoral varus derotational osteotomy in spastic cerebral palsy: the Rush rod. 61
31770291 2020
Clinical and Genetic Predictors of Priapism in Sickle Cell Disease: Results from the Recipient Epidemiology and Donor Evaluation Study III Brazil Cohort Study. 61
31668730 2019
Treatment for avascular necrosis of bone in people with sickle cell disease. 61
31803937 2019
31841494 2019
HbS/β+ thalassemia: Really a mild disease? A National survey from the AIEOP Sickle Cell Disease Study Group with genotype-phenotype correlation. 61
31788855 2019
Hip survival rate in the patients with avascular necrosis of femoral head after transtrochanteric rotational osteotomy: a systematic review and meta-analysis. 61
31855958 2019
Relationship of Plasminogen Activator Inhibitor 1 4G/5G Gene Polymorphism and Nontraumatic Lunatum Avascular Necrosis. 61
31806394 2019
Analysis of congruence for talar dome geometry among tali of different sizes. 61
31704589 2019
Comparing the efficacy of Cartiva synthetic cartilage implant hemiarthroplasty vs osteotomy for the treatment of conditions affecting the second metatarsal head. 61
31675598 2019
Ex situ reconstruction of comminuted radial head fractures: is it truly worth a try? 61
31385021 2019
The scapho-capitate syndrome: a case report with follow-up of three years. 61
31821301 2019

Variations for Avascular Necrosis

Expression for Avascular Necrosis

Search GEO for disease gene expression data for Avascular Necrosis.

Pathways for Avascular Necrosis

Pathways related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.95 COL2A1 BMP2

GO Terms for Avascular Necrosis

Cellular components related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 TRPV4 BMP2 ABCB1

Biological processes related to Avascular Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.46 COL2A1 BMP2
2 cartilage development GO:0051216 9.43 COL2A1 BMP2
3 inner ear development GO:0048839 9.4 COL2A1 BMP2
4 chondrocyte differentiation GO:0002062 9.37 COL2A1 BMP2
5 cellular response to BMP stimulus GO:0071773 9.32 COL2A1 BMP2
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.26 SREBF2 BMP2
7 proteoglycan metabolic process GO:0006029 9.16 COL2A1 BMP2
8 cartilage development involved in endochondral bone morphogenesis GO:0060351 8.96 TRPV4 COL2A1
9 regulation of response to osmotic stress GO:0047484 8.62 TRPV4 ABCB1

Sources for Avascular Necrosis

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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