ANFH1
MCID: AVS006
MIFTS: 43

Avascular Necrosis of Femoral Head, Primary, 1 (ANFH1)

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Avascular Necrosis of Femoral Head, Primary, 1

MalaCards integrated aliases for Avascular Necrosis of Femoral Head, Primary, 1:

Name: Avascular Necrosis of Femoral Head, Primary, 1 57 74 38
Avascular Necrosis of the Femoral Head 57 13
Avascular Necrosis of Femoral Head 74 37
Ischemic Necrosis of Femoral Head 57 74
Osteonecrosis of Femoral Head 57 74
Femur Head Necrosis 44 72
Anfh1 57 74
Femoral Head, Avascular Necrosis of; Anfh 57
Femoral Head, Avascular Necrosis of 57
Femoral Head, Aseptic Necrosis of 57
Necrosis, Avascular, Femoral Head 40
Aseptic Necrosis of Femoral Head 74
Avascular Necrosis of Femur Head 72
Anfh 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
patients present with groin pain
onset of symptoms in second to fifth decades of life


HPO:

32
avascular necrosis of femoral head, primary, 1:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

KEGG 37 H01529
MeSH 44 D005271
UMLS 72 C0015814 C0410480

Summaries for Avascular Necrosis of Femoral Head, Primary, 1

KEGG : 37
Avascular necrosis of the femoral head (ANFH) is one of the most common diseases of osteonecrosis that leads to destruction of the hip joint. Osteonecrosis is a pathological process in which cellular death in the bone constituents occurs because of decreased blood flow or an interruption in the blood supply. ANFH occurs mainly in young individuals between 30 and 50 years old. The clinical manifestations of ANFH, including pain on exertion, limping gait, and discrepancy in leg length, cause considerable disability. The etiology of ANFH is unknown, but previous studies have indicated that heritable thrombophilia and hypofibrinolysis, alcohol intake, and steroid use are risk factors for ANFH. Most cases are sporadic, but familial cases have been described. It has been reported Legg-Calve-Perthes disease (LCPD) is a particular type of femoral head necrosis occurring in children. It is more common among boys, and bilateral involvement occurs in 8-24% of cases. The disease is usually diagnosed among children under age 14 years, with a peak onset between 5 and 8 years of age. There is delayed skeletal maturation and impaired growth. In addition to congenital abnormalities, LCPD is associated with greater risk of cardiovascular diseases and diseases of the blood. Most cases are sporadic, but familial cases have been described. It has been reported that COL2A1 mutations are associated with this disease. Recent studies have suggested that an association exists between ANFH and genetic polymorphisms in the plasminogen activator inhibitor (SERPINE1), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (NOS3), and P-glycoprotein (ABCB1) genes.

MalaCards based summary : Avascular Necrosis of Femoral Head, Primary, 1, also known as avascular necrosis of the femoral head, is related to avascular necrosis of femoral head, primary, 2 and familial avascular necrosis of the femoral head. An important gene associated with Avascular Necrosis of Femoral Head, Primary, 1 is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are HIF-1 signaling pathway and VEGF signaling pathway. The drugs Heparin and Rivaroxaban have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Adipose, and related phenotypes are generalized osteoporosis and avascular necrosis of the capital femoral epiphysis

OMIM : 57 Avascular necrosis of the femoral head (ANFH) is a debilitating disease that usually leads to destruction of the hip joint in the third to fifth decade of life. The disorder is characterized by progressive pain in the groin, mechanical failure of the subchondral bone, and degeneration of the hip joint. Nearly one-half of patients require hip replacement before 40 years of age. ANFH represents a specific form of the broader disease category of osteonecrosis (summary by Mont and Hungerford, 1995). (608805)

UniProtKB/Swiss-Prot : 74 Avascular necrosis of femoral head, primary, 1: A disease characterized by mechanical failure of the subchondral bone, and degeneration of the hip joint. It usually leads to destruction of the hip joint in the third to fifth decade of life. The clinical manifestations, such as pain on exertion, a limping gait, and a discrepancy in leg length, cause considerable disability. ANFH1 inheritance is autosomal dominant.

Related Diseases for Avascular Necrosis of Femoral Head, Primary, 1

Diseases in the Familial Avascular Necrosis of the Femoral Head family:

Avascular Necrosis of Femoral Head, Primary, 1 Avascular Necrosis of Femoral Head, Primary, 2

Diseases related to Avascular Necrosis of Femoral Head, Primary, 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 160, show less)
# Related Disease Score Top Affiliating Genes
1 avascular necrosis of femoral head, primary, 2 12.3
2 familial avascular necrosis of the femoral head 11.7
3 avascular necrosis 10.9
4 sickle cell disease 10.8
5 legg-calve-perthes disease 10.6
6 sickle cell anemia 10.5
7 lymphocytic leukemia 10.5
8 alcohol dependence 10.4
9 thoracoabdominal syndrome 10.4
10 leukemia, acute lymphoblastic 10.4
11 b-cell lymphoma 10.4
12 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
13 graft-versus-host disease 10.3
14 thalassemia 10.3
15 gout 10.3
16 frozen shoulder 10.3
17 hemoglobinopathy 10.3
18 bursitis 10.3
19 osteochondrosis 10.3
20 osteochondritis dissecans 10.3
21 47,xyy 10.3
22 slipped capital femoral epiphysis 10.3
23 back pain 10.3
24 osteonecrosis 10.3
25 severe acute respiratory syndrome 10.3
26 lymphoma 10.3
27 chondrocalcinosis 10.3
28 vascular disease 10.3
29 gaucher's disease 10.3
30 cerebral palsy 10.3
31 synovitis 10.3
32 purpura 10.3
33 systemic scleroderma 10.3
34 osteoporosis 10.3
35 bone mineral density quantitative trait locus 8 10.3
36 bone mineral density quantitative trait locus 15 10.3
37 traumatic avascular necrosis 10.3
38 systemic lupus erythematosus 10.2
39 osteoarthritis 10.2
40 lupus erythematosus 10.2
41 hydrops, lactic acidosis, and sideroblastic anemia 10.1
42 breast cancer 10.1
43 coxa vara 10.1
44 multiple sclerosis 10.1
45 hypercholesterolemia, familial, 1 10.1
46 hypertriglyceridemia, familial 10.1
47 leukemia, chronic lymphocytic 10.1
48 metachondromatosis 10.1
49 scleroderma, familial progressive 10.1
50 thrombocytopenic purpura, autoimmune 10.1
51 trichorhinophalangeal syndrome, type i 10.1
52 pituitary adenoma 4, acth-secreting 10.1
53 gaucher disease, type i 10.1
54 immune deficiency disease 10.1
55 familial mediterranean fever 10.1
56 myeloma, multiple 10.1
57 neuroblastoma 1 10.1
58 intervertebral disc disease 10.1
59 alpha-thalassemia 10.1
60 leukemia, chronic myeloid 10.1
61 kawasaki disease 10.1
62 beta-thalassemia 10.1
63 exanthem 10.1
64 inflammatory bowel disease 10.1
65 colitis 10.1
66 fibrous dysplasia 10.1
67 osteomyelitis 10.1
68 rickets 10.1
69 brucellosis 10.1
70 sarcoma 10.1
71 pituitary apoplexy 10.1
72 male infertility 10.1
73 leukemia 10.1
74 acute leukemia 10.1
75 leukostasis 10.1
76 renal osteodystrophy 10.1
77 hepatitis c 10.1
78 thrombocytosis 10.1
79 relapsing-remitting multiple sclerosis 10.1
80 hemangioma 10.1
81 antiphospholipid syndrome 10.1
82 arthropathy 10.1
83 liver disease 10.1
84 spindle cell sarcoma 10.1
85 pustulosis of palm and sole 10.1
86 infertility 10.1
87 adenoma 10.1
88 spinal stenosis 10.1
89 chronic kidney disease 10.1
90 septic arthritis 10.1
91 collagen disease 10.1
92 ulcerative colitis 10.1
93 myeloid leukemia 10.1
94 psoriasis 10.1
95 lipid storage disease 10.1
96 stomatitis 10.1
97 hypersensitivity vasculitis 10.1
98 trichorhinophalangeal syndrome 10.1
99 type ii collagen disorders 10.1
100 catastrophic antiphospholipid syndrome 10.1
101 chronic graft versus host disease 10.1
102 leukemia, b-cell, chronic 10.1
103 oncogenic osteomalacia 10.1
104 skeletal dysplasias 10.1
105 aneurysm 10.1
106 cerebral aneurysms 10.1
107 head injury 10.1
108 rapidly involuting congenital hemangioma 10.1
109 specific language disorder 10.1
110 secondary avascular necrosis 10.1
111 rare surgical neurologic disease 10.1
112 leukemia, acute myeloid 10.1
113 coronary heart disease 1 10.1
114 asthma-related traits 2 10.1
115 primary pigmented nodular adrenocortical disease 10.1
116 myeloproliferative neoplasm 10.1
117 thrombophilia 10.1
118 myopathy 10.1
119 connective tissue disease 10.1
120 idiopathic avascular necrosis 10.1
121 rare disease in surgical orthopedic 10.1
122 hyperuricemia 10.1
123 thrombophilia due to activated protein c resistance 10.1
124 deficiency anemia 10.1
125 spondyloarthropathy 1 10.0
126 thrombophilia due to thrombin defect 10.0
127 inflammatory spondylopathy 10.0
128 spondylitis 10.0
129 psoriasis 1 10.0
130 pituitary hormone deficiency, combined, 2 10.0
131 bone mineral density quantitative trait locus 3 10.0
132 human immunodeficiency virus type 1 10.0
133 bone disease 10.0
134 bone resorption disease 10.0
135 osteomalacia 10.0
136 alcohol use disorder 10.0
137 impotence 10.0
138 arteriosclerosis 10.0
139 lipid metabolism disorder 10.0
140 pituitary adenoma 10.0
141 femoral neuropathy 10.0
142 arteriosclerosis obliterans 10.0
143 acth-secreting pituitary adenoma 10.0
144 vasculitis 10.0
145 neuropathy 10.0
146 hypopituitarism 10.0
147 pulmonary embolism 10.0
148 bone marrow necrosis 10.0
149 raynaud phenomenon 10.0
150 hypoxia 10.0
151 non-acquired combined pituitary hormone deficiency 10.0
152 polykaryocytosis inducer 9.9
153 viral hepatitis 9.9
154 testicular cancer 9.9
155 mammary paget's disease 9.9
156 seminoma 9.9
157 brain edema 9.9
158 compartment syndrome 9.9
159 chorioretinitis 9.9
160 heavy metal poisoning 9.9

Graphical network of the top 20 diseases related to Avascular Necrosis of Femoral Head, Primary, 1:



Diseases related to Avascular Necrosis of Femoral Head, Primary, 1

Symptoms & Phenotypes for Avascular Necrosis of Femoral Head, Primary, 1

Human phenotypes related to Avascular Necrosis of Femoral Head, Primary, 1:

32 (showing 2, show less)
# Description HPO Frequency HPO Source Accession
1 generalized osteoporosis 32 occasional (7.5%) HP:0040160
2 avascular necrosis of the capital femoral epiphysis 32 HP:0005743

Symptoms via clinical synopsis from OMIM:

57
Skeletal Pelvis:
narrowing of joint space
degeneration of hip joint

Skeletal Spine:
mild scoliosis (in some patients)

Skeletal:
generalized osteoporosis (in some patients)

Skeletal Limbs:
avascular necrosis of the femoral head
cystic changes of femoral head
sclerosis of femoral head
necrosis of bone and marrow tissue on histopathology

Clinical features from OMIM:

608805

Drugs & Therapeutics for Avascular Necrosis of Femoral Head, Primary, 1

Drugs for Avascular Necrosis of Femoral Head, Primary, 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 84, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
2
Rivaroxaban Approved Phase 4 366789-02-8
3
Dalteparin Approved Phase 4 9005-49-6
4
Enoxaparin Approved Phase 4 9005-49-6 772
5
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
6 Anesthetics Phase 4
7 Peripheral Nervous System Agents Phase 4
8
protease inhibitors Phase 4
9 Antithrombin III Phase 4
10 HIV Protease Inhibitors Phase 4
11 Serine Proteinase Inhibitors Phase 4
12 Antithrombins Phase 4
13 Heparin, Low-Molecular-Weight Phase 4
14 Factor Xa Inhibitors Phase 4
15 Anticoagulants Phase 4
16 calcium heparin Phase 4
17 Nootropic Agents Phase 4
18 Cholinergic Agents Phase 4
19 Neurotransmitter Agents Phase 4
20 Cholinesterase Inhibitors Phase 4
21 Autonomic Agents Phase 4
22
Zoledronic Acid Approved Phase 3 118072-93-8 68740
23
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
24
Vitamin D Approved, Nutraceutical, Vet_approved Phase 3 1406-16-2
25
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
26 Diphosphonates Phase 3
27 Bone Density Conservation Agents Phase 3
28 Hemostatics Phase 3
29 Coagulants Phase 3
30 Calcium, Dietary Phase 3
31 Calciferol Phase 3
32 Fibrin Tissue Adhesive Phase 3
33 Ibandronic Acid Phase 3
34 Cyclooxygenase Inhibitors Phase 3
35 Analgesics, Non-Narcotic Phase 3
36 Fibrinolytic Agents Phase 3
37 Analgesics Phase 3
38 Anti-Inflammatory Agents, Non-Steroidal Phase 3
39 Anti-Inflammatory Agents Phase 3
40 Antipyretics Phase 3
41 Platelet Aggregation Inhibitors Phase 3
42 Antirheumatic Agents Phase 3
43
Ketoconazole Approved, Investigational Phase 2 65277-42-1 47576
44
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
45 Hormones Phase 2
46 Hormone Antagonists Phase 2
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
48 14-alpha Demethylase Inhibitors Phase 2
49 Cytochrome P-450 CYP3A Inhibitors Phase 2
50 Cytochrome P-450 Enzyme Inhibitors Phase 2
51 Antifungal Agents Phase 2
52 Anti-Infective Agents Phase 2
53 Steroid Synthesis Inhibitors Phase 2
54
Cisatracurium Approved Early Phase 1 96946-41-7
55
Propofol Approved, Investigational, Vet_approved Early Phase 1 2078-54-8 4943
56
Remifentanil Approved Early Phase 1 132875-61-7 60815
57
Sufentanil Approved, Investigational Early Phase 1 56030-54-7 41693
58
Ropivacaine Approved Early Phase 1 84057-95-4 71273 175805
59
Tranexamic Acid Approved 1197-18-8 5526
60
Prednisolone phosphate Approved, Vet_approved 302-25-0
61
Methylprednisolone Approved, Vet_approved 83-43-2 6741
62
Methylprednisolone hemisuccinate Approved 2921-57-5
63
Prednisolone Approved, Vet_approved 50-24-8 5755
64
Tramadol Approved, Investigational 27203-92-5 33741
65
Oxycodone Approved, Illicit, Investigational 76-42-6 5284603
66
Gabapentin Approved, Investigational 60142-96-3 3446
67
Celecoxib Approved, Investigational 169590-42-5 2662
68
Meperidine Approved 57-42-1 4058
69
Pamidronate Approved 40391-99-9 4674
70
Prednisolone hemisuccinate Experimental 2920-86-7
71 glucocorticoids
72 Anesthetics, Local Early Phase 1
73 Narcotics Early Phase 1
74 Adjuvants, Anesthesia Early Phase 1
75 Central Nervous System Depressants Early Phase 1
76 Hypnotics and Sedatives Early Phase 1
77 Anesthetics, General Early Phase 1
78 Anesthetics, Intravenous Early Phase 1
79 Analgesics, Opioid Early Phase 1
80 Pharmaceutical Solutions
81 Antifibrinolytic Agents
82 Prednisolone acetate
83 Methylprednisolone Acetate
84 Calamus

Interventional clinical trials:

(showing 46, show less)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety for Prophylaxis of Deep Vein Thrombosis Following Total Hip Arthroplasty Completed NCT02379663 Phase 4 Rivaroxaban;Enoxaparin
2 Randomised Controlled Double-blind Monocenter Therapy Study Validating the Benefit From Information Provided by Image Free Navigation System on the Precision of the Placement of Acetabular Component in Patients Undergoing Primary THA Completed NCT01496300 Phase 4
3 Is Ceramic-on-Ceramic THA Superior to Ceramic-on-Highly Cross-Linked Polyethylene THA in Patients Less Than 55 Years Old? Completed NCT03639532 Phase 4
4 Comparison of the Outcomes of Ultra-Short Anatomic and Conventional Cementless Stems in Patients Younger Than Fifty-Five Years Old Completed NCT02338596 Phase 4
5 Control Study of Implantation of Enriched Bone Marrow Cells for the Treatment of Avascular Necrosis of Femoral Head Unknown status NCT01613612 Phase 2, Phase 3
6 Multicenter, Open-labeled, Randomized Clinical Trial to Determine the Efficacy of Zoledronic Acid in Preventing Collapse of the Osteonecrotic Femoral Head Completed NCT00939900 Phase 3 zoledronic acid (aclasta)
7 A Randomized, Controlled, Multicenter Study to Evaluate Efficacy and Safety of Fibrin Sealant VH S/D for Hemostasis in Subjects Undergoing Total Hip Replacement Completed NCT00161902 Phase 3 Fibrin Sealant Vapor-Heated Solvent/Detergent-treated
8 Study Into the Effect of Ibandronate for the Treatment of Bone Marrow Edema in Relation to Spontaneous or Non-traumatic Osteonecrosis of the Knee: A Randomized Double-blind, Placebo-controlled Trial Completed NCT00532220 Phase 3 Ibandronate IV;Placebo
9 Aspirin (Acetylsalicylic Acid) in the Prevention of Collapse of the Femoral Head in Early-stage Non-traumatic Osteonecrosis: a Two-year Multicenter, Prospective, Randomized, Double-blind, Placebo-controlled Study Recruiting NCT03405974 Phase 3 Aspirin;Placebo
10 Combined Treatment of Early and Advanced Osteonecrosis of the Femoral Head With Core Decompression and Grafting With Demineralized Bone Matrix (DBM) or Homologous Lyophilized Bone Chips (LBC) Together With Platelet-rich-fibrin (PRF) and Concentrated Bone Marrow (CBM) Active, not recruiting NCT01892514 Phase 3
11 The Study of Early Stage Osteonecrosis of Femoral Head With Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSC) Unknown status NCT03180463 Phase 1, Phase 2 Allogeneic umbilical cord mesenchymal stem cells (SCLnow 19#)
12 Treatment of Osteonecrosis of the Femoral Head by Implantation of Preosteoblastic Cells: a Randomized, Controlled, Single Blind Pilot Study Completed NCT02890537 Phase 2 Core decompression/PREOB® implantation;Core decompression/BMC implantation
13 Restoration of Muscle Following Hip Surgery Completed NCT00393848 Phase 2 Essential amino acid supplement;Ketoconazole;Placebo
14 Evaluation of Safety and Feasibility of Bone Marrow Derived Autologous MSCs to Enhance Bone Healing in Patients With Avascular Necrosis of the Femoral Head Active, not recruiting NCT02065167 Phase 2
15 A Pilot Clinical Trial of "ex Vivo" Expanded Autologous Bone Marrow Mesenchymal Stem Cells Fixed in Allogenic Human Bone Tissue (XCEL-MT-OSTEO- ALPHA) in Osteonecrosis of the Femoral Head Active, not recruiting NCT01605383 Phase 1, Phase 2
16 Molecular Genetic Study of Avascular Necrosis of the Femoral Head-Revealing ANFH Pathogenesis Mechanism by Cell and Animal Models Unknown status NCT00260897
17 Porous Tantalum Rods Improve the Hip Joint Function of Patients With Avascular Necrosis of the Femoral Head After Femoral Neck Fracture Surgery: a Randomized Controlled Trial Unknown status NCT02877472
18 Genome-wide Association Study Identified Susceptibility Loci for Glucocorticoid-induced Femur Head Necrosis in the Chinese Population Unknown status NCT02365077
19 Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up Unknown status NCT00172315
20 Feasibility of Implantation of Cemented Femoral Stem in the Treatment of Osteoporotic Femoral Neck Fracture in Elderly Patients: a Randomized Controlled Trial Unknown status NCT02901938
21 The Clinical Investigation of Anesthesia Depth's Influence in Total Intravenous Anesthesia on Postoperative Delirium of Elderly Patients Unknown status NCT02972762 Early Phase 1 Diprivan
22 Safety and Efficacy of Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Avascular Necrosis of the Femoral Head Completed NCT01643655
23 The Effect of Tranexamic Acid on Blood Coagulation After Colloid Infusion During Surgery: Rotational Thromboelastography Measurement Completed NCT02146456 Tranexamic Acid
24 Examine the Possible Association of Hepatic CYP3A Activity and the Susceptibility to Femur Head Necrosis Completed NCT00244400
25 Transcription Factor Runx2 in Necrotic Femoral Head Tissue: Study Protocol for a Retrospective Non-randomized, Parallel-controlled Clinical Trial Completed NCT02735538
26 A Comparison of Two Different Surgical Techniques for Total Hip Resurfacing Completed NCT00750984
27 Multicentric Observational Study Evaluating Clinical and Radiological Results of a Total Hip Arthroplasty Using a Ceramic Friction Pair Completed NCT02062437
28 Multicentre, Observational Study Evaluating the Clinical and Radiological Outcomes of Hip Arthroplasty Using the Dual Mobility Cup Completed NCT02062450
29 The Effect of Autologous Bone Marrow Concentration Combined With Core Decompression for Avascular Necrosis of Femoral Head Recruiting NCT03787329
30 Multicentric Observational Study to Evaluate Long-Term Outcome, Performance, and Safety of Tornier's Implantable Devices in Hip Arthroplasty Recruiting NCT02230826
31 The Medacta SMS Femoral Stem Component. A Multi-National, Multi-Centre, Clinical Surveillance Study Recruiting NCT02748408
32 The Verification Study on the Early Fixation/ Stability of Tritanium Cup Recruiting NCT02552069
33 Prospective, Non-Interventional, Multicenter, Post-Market Clinical Follow-up Study CoreHip® Recruiting NCT03685110
34 Actis Total Hip System 2 Year Follow-up Recruiting NCT02783274
35 A Prospective, Non-randomized, Consecutive Series, Multicentre, Observational Study to Evaluate the Clinical Outcome of ceramic-on- Ceramic Hip Resurfacing Arthroplasty Using the Ceramic, Non-porous, Non- Cemented H1 Hip Resurfacing Arthroplasty Recruiting NCT03326804
36 Prospective Randomized Controlled Trial of Impact of Enhanced Recovery After Surgery(ERAS) for Outcomes of Total Knee and Hip Arthroplasty Recruiting NCT03869203
37 Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease Recruiting NCT02040714
38 Study of Modifications of the Composition and Structure in the Aseptic Osteonecrosis of the Femoral Head and Etiopathogenic MRI Correlations Active, not recruiting NCT02733900
39 Hip Fracture in Individuals Under 60 Years of Age: A Prospective Multi-center Study of the Epidemiology, Treatment, Outcome and Patient Satisfaction Regarding Hip Fractures Active, not recruiting NCT03848195
40 Prospective Clinical 5-year Follow-up of the LINK® SP-CL® Hip Prosthesis Stem Active, not recruiting NCT02288117
41 Post-Market Data Collection for Biologically Assisted Core Decompression of the Femoral Head Using the PerFuse Instrument and BioCUE Enrolling by invitation NCT02662881
42 Investigation of the Value of Femoral Shortening Osteotomy During Open Treatment of Developmental Dislocation of the Hip in Waliking Age Group Not yet recruiting NCT02633904
43 The Use of Bisphosphonates in the Treatment of Avascular Necrosis of the Femoral Head Terminated NCT02007915 Pamidronate Disodium
44 Evaluation of the Efficiency of Autologous Bone Marrow no Concentrated to Associate at BMP7 Treatment of Necrosis of the Femoral Head of the Adult Terminated NCT02655120
45 Outcome After Avascular Necrosis of the Femoral Head in Young Patients - Retrospective Analysis With a Min. 10-year Follow-up Withdrawn NCT03753282
46 Non-Interventional Post Market Clinical Follow-up Study Excia T® Cementless EBRA Study Withdrawn NCT02799654

Search NIH Clinical Center for Avascular Necrosis of Femoral Head, Primary, 1

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Stem-cell-based therapeutic approaches for Avascular Necrosis of Femoral Head, Primary, 1:
RNL-Astrostem, adipose-derived mesenchymal stem cells for avascular necrosis of the femoral head
Embryonic/Adult Cultured Cells Related to Avascular Necrosis of Femoral Head, Primary, 1:
Adipose-derived mesenchymal stem cells PMIDs: 21303266 24341080

Cochrane evidence based reviews: femur head necrosis

Genetic Tests for Avascular Necrosis of Femoral Head, Primary, 1

Anatomical Context for Avascular Necrosis of Femoral Head, Primary, 1

MalaCards organs/tissues related to Avascular Necrosis of Femoral Head, Primary, 1:

41
Bone, Endothelial, Bone Marrow, Pituitary, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Avascular Necrosis of Femoral Head, Primary, 1:
# Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Avascular Necrosis of Femoral Head, Primary, 1

Articles related to Avascular Necrosis of Femoral Head, Primary, 1:

(showing 224, show less)
# Title Authors PMID Year
1
Avascular necrosis of the femoral head due to a novel C propeptide mutation in COL2A1. 8 71
21671384 2011
2
Type II collagen gene variants and inherited osteonecrosis of the femoral head. 8 71
15930420 2005
3
Type II Collagen Disorders Overview 71
31021589 2019
4
A recurrent mutation in type II collagen gene causes Legg-Calvé-Perthes disease in a Japanese family. 71
17394019 2007
5
Autosomal dominant avascular necrosis of femoral head in two Taiwanese pedigrees and linkage to chromosome 12q13. 8
15179599 2004
6
Osteonecrosis in patients with SLE. 8
12794257 2003
7
Pathogenesis and natural history of osteonecrosis. 8
12430099 2002
8
Total hip replacement in irradiated hips. A retrospective study of 71 cases. 8
7593093 1995
9
Non-traumatic avascular necrosis of the femoral head. 8
7890797 1995
10
Sickle cell disease as a cause of osteonecrosis of the femoral head. 8
1944426 1991
11
Systemic necrotizing vasculitis causing bone necrosis. 8
2897791 1988
12
Focused extra-corporeal shockwave treatment during early stage of osteonecrosis of femoral head. 38
31306227 2019
13
Significant association between RETN genetic polymorphisms and alcohol-induced osteonecrosis of femoral head. 38
31207150 2019
14
Glucocorticoid Enhanced the Expression of Ski in Osteonecrosis of Femoral Head: The Effect on Adipogenesis of Rabbit BMSCs. 38
31359074 2019
15
Diffusion tensor imaging of the sciatic and femoral nerves in unilateral osteoarthritis of the hip and osteonecrosis of femoral head: Comparison of the affected and normal sides. 38
29862862 2019
16
Prediction of femoral head avascular necrosis following femoral neck fracture: "pin-tract sign" of 99mTc-HDP pinhole bone scan after metallic fixation. 38
31280602 2019
17
Radiographic evaluation of linear wear of bipolar hemiarthroplasty devices in vivo. 38
31316231 2019
18
[Clinical study for preoperative traction on impact of osteonecrosis of femoral head in patients with femoral neck fractures]. 38
31197991 2019
19
[Extracorporeal shockwave therapy for osteonecrosis of femoral head: traps and challenges]. 38
31197988 2019
20
Huo Xue Tong Luo capsule ameliorates osteonecrosis of femoral head through inhibiting lncRNA-Miat. 38
30970282 2019
21
Osteonecrosis of Femoral Head is Associated with Congenital Multiple Pituitary Hormone Deficiency: Report of Three Cases and Literature Review. 38
30966827 2019
22
Comparison of sartorius muscle-pedicle and circumflex iliac deep bone flap grafts in the treatment of early non-traumatic osteonecrosis of femoral head in young adults. 38
31031129 2019
23
Porous, lithium-doped calcium polyphosphate composite scaffolds containing vascular endothelial growth factor (VEGF)-loaded gelatin microspheres for treating glucocorticoid-induced osteonecrosis of the femoral head. 38
30802884 2019
24
Long-term outcomes of Phemister bone grafting for patients with non-traumatic osteonecrosis of the femoral head. 38
29916000 2019
25
Elevated plasma cartilage oligomeric matrix protein (COMP) level are associated with the progression of non-traumatic osteonecrosis of femoral head. 38
30217750 2019
26
Grafting, Stripping and Stapling of Helical Peptides from the Dimerization Interface of ONFH-Related Bone Morphogenetic Protein-2. 38
30604108 2019
27
CircUSP45 inhibited osteogenesis in glucocorticoid-induced osteonecrosis of femoral head by sponging miR-127-5p through PTEN/AKT signal pathway: Experimental studies. 38
30579595 2019
28
Outcomes for core decompression with multiple drilling of the osteonecrosis of the femoral head in patients with solid organ transplantation. 38
30376800 2018
29
Impact of acetabular reaming depth on reconstruction of rotation center in primary total hip arthroplasty. 38
30497444 2018
30
Using Naive Bayes Classifier to predict osteonecrosis of the femoral head with cannulated screw fixation. 38
30097310 2018
31
The Glycosaminoglycan Content of Hip Cartilage in Osteonecrosis of Femoral Head: Evaluation with Delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage. 38
30282478 2018
32
Chinese herbal medicine formulas as adjuvant therapy for osteonecrosis of the femoral head: A systematic review and meta-analysis of randomized controlled trials. 38
30200126 2018
33
[Application of arthroscopic surgery combined with direct anterior approach in hip diseases]. 38
30129333 2018
34
IL-9 exhibits elevated expression in osteonecrosis of femoral head patients and promotes cartilage degradation through activation of JAK-STAT signaling in vitro. 38
29775946 2018
35
[Microarchitecture features and pathology of necrotic region in patients with steroid-induced and alcohol-induced osteonecrosis of femoral head]. 38
30129310 2018
36
Nationwide study on the risk of unprovoked venous thromboembolism in non-traumatic osteonecrosis of femoral head. 38
29541810 2018
37
Effect of glucocorticoids on miRNA expression spectrum of rat femoral head microcirculation endothelial cells. 38
29408208 2018
38
Effectiveness of various hip preservation treatments for non-traumatic osteonecrosis of the femoral head: A network meta-analysis of randomized controlled trials. 38
29291916 2018
39
High levels of GSK-3β signalling reduce osteogenic differentiation of stem cells in osteonecrosis of femoral head. 38
29136173 2018
40
IL-21 Enhances the Degradation of Cartilage Through the JAK-STAT Signaling Pathway During Osteonecrosis of Femoral Head Cartilage. 38
29247327 2018
41
Screening of Serum Protein Markers for Avascular Osteonecrosis of Femoral Head Differentially Expressed after Treatment with Yuanshi Shengmai Chenggu Tablets. 38
29750162 2018
42
Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head-A first multicentre, randomised, double-blind, placebo-controlled clinical trial. 38
29662777 2018
43
Early results of surgery for femoroacetabular impingement in patients with osteonecrosis of femoral head. 38
30398961 2018
44
Osteonecrosis of the femoral head in people living with HIV: anatomopathological description and p24 antigen test. 38
29872352 2018
45
Risk Factors for Neck Shortening in Patients with Valgus Impacted Femoral Neck Fractures Treated with Three Parallel Screws: Is Bone Density an Affecting Factor? 38
29250503 2017
46
[Study on the risk factors for the misdiagnosis of femoral head osteonecrosis]. 38
29457389 2017
47
[Prevention for glucocorticoid-induced osteonecrosis of femoral head: a long-term clinical follow-up trail]. 38
29141357 2017
48
Significance of Lateral Pillar in Osteonecrosis of Femoral Head: A Finite Element Analysis. 38
29067956 2017
49
[The new concept of prevention and treatment for Glucocorticoid-induced osteonecrosis of femoral head]. 38
29141355 2017
50
MMP9 polymorphism is associated with susceptibility to non-traumatic osteonecrosis of femoral head in a Chinese Han population. 38
29137306 2017
51
The genetic association between PON1 polymorphisms and osteonecrosis of femoral head: A case-control study. 38
29049204 2017
52
MiR-146a inhibits proliferation and induces apoptosis in murine osteoblastic MC3T3-E1 by regulating Bcl2. 38
28975995 2017
53
Predicting the collapse of the femoral head due to osteonecrosis: From basic methods to application prospects. 38
29662770 2017
54
Association between alcohol-induced osteonecrosis of femoral head and risk variants of MMPS in Han population based on a case-control study. 38
28969088 2017
55
[A summary of hip-preservation surgery based on peri-collapse stage of osteonecrosis of femoral head]. 38
29806443 2017
56
Histological fibrosis may predict the failure of core decompression in the treatment of osteonecrosis of the femoral head. 38
28689862 2017
57
Characteristics of bone turnover markers in rapidly destructive coxopathy. 38
27550182 2017
58
Heterotopic ossification related to the use of recombinant human BMP-2 in osteonecrosis of femoral head. 38
28682898 2017
59
Effects of Modified Qing'e Pill () on expression of adiponectin, bone morphogenetic protein 2 and coagulation-related factors in patients with nontraumatic osteonecrosis of femoral head. 38
27154871 2017
60
[Technical summary and modified instruments of free vascularized fibular grafting for osteonecrosis of femoral head]. 38
29786240 2017
61
Extracorporeal shockwave therapy in osteonecrosis of femoral head: A systematic review of now available clinical evidences. 38
28121934 2017
62
Long non-coding RNA HOTAIR inhibits miR-17-5p to regulate osteogenic differentiation and proliferation in non-traumatic osteonecrosis of femoral head. 38
28207735 2017
63
Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level. 38
28167850 2017
64
Ethyl acetate fraction of Huogu formula inhibits adipogenic differentiation of bone marrow stromal cells via the BMP and Wnt signaling pathways. 38
28529456 2017
65
[Comparison of core decompression with stem cell transplantation and tantalum rod implanting in treating stage II non-traumatic osteonecrosis of femoral head]. 38
29292887 2016
66
Osteoprotegerin polymorphisms are associated with alcohol-induced osteonecrosis of femoral head in Chinese Han population from Henan province. 38
27994198 2016
67
Quality of Life in Sickle Cell Patients After Cementless Total Hip Arthroplasty. 38
27240962 2016
68
Treatment of osteonecrosis of the femoral head with free vascularized fibular grafting: Results of 7.6-year follow-up. 38
27865611 2016
69
Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis. 38
27374150 2016
70
Result of Modular Necks in Primary Total Hip Arthroplasty with a Average Follow-up of Four Years. 38
27777916 2016
71
Plasma ghrelin and von Willebrand Factor levels in non-traumatic osteonecrosis of femoral head. 38
26351113 2016
72
Combined with Bone Marrow-Derived Cells and rhBMP-2 for Osteonecrosis after Femoral Neck Fractures in Children and Adolescents: A case series. 38
27477836 2016
73
Osteosynthesis of ununited femoral neck fracture by internal fixation combined with iliac crest bone chips and muscle pedicle bone grafting. 38
27512217 2016
74
[Study on the Distribution of Constitutions of Chinese Medicine in Patients with Osteonecrosis of Femoral Head]. 38
27491221 2016
75
Core decompression versus other joint preserving treatments for osteonecrosis of the femoral head: a meta-analysis. 38
27298230 2016
76
MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3. 38
26932538 2016
77
[CLINICAL APPLICATION OF THREE DIMENSIONAL PRINTED NAVIGATION TEMPLATES FOR TREATMENT OF OSTEONECROSIS OF FEMORAL HEAD WITH PEDICLED ILIAC BONE GRAFT]. 38
27281887 2016
78
[OBSERVATION OF EFFECTIVENESS OF HIP RESURFACING ARTHROPLASTY IN TREATMENT OF OSTEONECROSIS OF FEMORAL HEAD IN YOUNG AND MIDDLE-AGED PATIENTS]. 38
27276801 2016
79
Multicentric epidemiologic study on six thousand three hundred and ninety five cases of femoral head osteonecrosis in China. 38
26660727 2016
80
Aseptic necrosis of the femoral head after pregnancy: a case report. 38
27795792 2016
81
[Treatment of Steroid-induced Osteonecrosis of Femoral Head by Porous Tantalum Rod and Gugutou Huaisiyu Capsule]. 38
26955675 2016
82
[Centro-medullary nailing in the complex fractures of the upper end of the humerus: preliminary results in 6 cases]. 38
28250878 2016
83
Osteonecrosis of Femoral Head Treated with Extracorporeal Shock Wave Therapy: Analysis of Short-term Clinical Outcomes of Treatment with Radiologic Staging. 38
27536633 2015
84
[Proximal femoral geometry changes after femoral neck fracture treated with total hip arthroplasty]. 38
26647557 2015
85
Osteonecrosis of the femoral head: diagnosis and classification systems. 38
26088795 2015
86
Identification of differentially expressed microRNAs involved in non-traumatic osteonecrosis through microRNA expression profiling. 38
25863178 2015
87
Clinical trial for idiopathic osteonecrosis of femoral head by multipotent mesenchynal stromal cells. 38
30458099 2015
88
[Application of minimally invasive, decompression bone graft implantation combined with metal trabecular bone reconstruction system for early stage osteonecrosis of femoral head]. 38
26193720 2015
89
Outcome of the treatment of osteonecrosis of femoral head using the core decompression with bone impaction grafting. 38
25936699 2015
90
Core decompression treatment of early-stage osteonecrosis of femoral head resulted from venous stasis or artery blood supply insufficiency. 38
25582883 2015
91
Traumatic Hip Dislocation in A Child Younger Than 3 Years- A rare Case Report And Review of Literature. 38
27299050 2015
92
Stem cells for reutilization in bone regeneration. 38
25491657 2015
93
Timing of internal fixation of femoral neck fractures. A systematic review and meta-analysis of the final outcome. 38
25616675 2015
94
Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study. 38
25112719 2015
95
Early Steroid-Induced Osteonecrosis of Rabbit Femoral Head and Panax notoginseng Saponins: Mechanism and Protective Effects. 38
25866538 2015
96
Management of femoral head osteonecrosis: Current concepts. 38
25593355 2015
97
Genetic association of the ApoB and ApoA1 gene polymorphisms with the risk for alcohol-induced osteonecrosis of femoral head. 38
26617857 2015
98
ADAMTS-7 exhibits elevated expression in cartilage of osteonecrosis of femoral head and has a positive correlation with TNF- α and NF- κ B P65. 38
25653475 2015
99
The association between VEGF -634C/G polymorphisms and osteonecrosis of femoral head: a meta-analysis. 38
26309590 2015
100
Combined effect of tnf-α polymorphisms and hypoxia on steroid-induced osteonecrosis of femoral head. 38
26045843 2015
101
Association of apolipoprotein A5 genetic polymorphisms with steroid-induced osteonecrosis of femoral head in a Chinese Han population. 38
25515090 2014
102
Midterm results of treating femoral head osteonecrosis with autogenous corticocancellous bone grafting. 38
25717446 2014
103
A genetic pedigree analysis to identify gene mutations involved in femoral head necrosis. 38
25050885 2014
104
Quality of sexual life after total hip arthroplasty in male patients with osteonecrosis of femoral head. 38
24664449 2014
105
An exploratory clinical trial for idiopathic osteonecrosis of femoral head by cultured autologous multipotent mesenchymal stromal cells augmented with vascularized bone grafts. 38
24593258 2014
106
[Preliminary analysis of differentially expressed genes in steroid-induced osteonecrosis of femoral head by gene microarray]. 38
25073278 2014
107
Pulsed electromagnetic fields protect the balance between adipogenesis and osteogenesis on steroid-induced osteonecrosis of femoral head at the pre-collapse stage in rats. 38
24421074 2014
108
Plasma interleukin 33 level in patients with osteonecrosis of femoral head: an alarmin for osteonecrosis of the femoral head? 38
24430213 2014
109
Osteonecrosis of femoral head occurred after stent placement of femoral artery. 38
25197597 2014
110
Efficacy of alendronate for preventing collapse of femoral head in adult patients with nontraumatic osteonecrosis. 38
25535614 2014
111
Intralesional autologous mesenchymal stem cells in management of osteonecrosis of femur: a preliminary study. 38
23852661 2013
112
[A comparative study on short-term effectiveness between cemented and uncemented total hip arthroplasty for osteonecrosis of femoral head after renal transplantation]. 38
24640354 2013
113
Modified surgical techniques of free vascularized fibular grafting for treatment of the osteonecrosis of femoral head: results from a series of 407 cases. 38
23907776 2013
114
Association of a polymorphism in PON-1 gene with steroid-induced osteonecrosis of femoral head in Chinese Han population. 38
24206655 2013
115
Digital subtraction angiography in selection of the vascularized greater trochanter bone grafting for treatment of osteonecrosis of femoral head. 38
24115327 2013
116
Prevalence of genetic risk factors related with thrombophilia and hypofibrinolysis in patients with osteonecrosis of the femoral head in Poland. 38
24025446 2013
117
[Treating early-to-middle stage nontraumatic osteonecrosis of femoral head patients by jianpi huogu recipe: a retrospective study]. 38
24325053 2013
118
Association between PAI-1 4G/5G Polymorphisms and osteonecrosis of femoral head: a meta-analysis. 38
23856555 2013
119
Meta-analysis of Factor V Leiden G1691A polymorphism and osteonecrosis of femoral head susceptibility. 38
24648992 2013
120
Regulation of expression of HGF in BM-MSCs by baculovirus-mediated transduction. 38
23404631 2013
121
Elevated level of membrane microparticles in the disease of steroid-induced vascular osteonecrosis. 38
23851782 2013
122
Avascular osteonecrosis of femoral head in a postoperative patient of pituitary Cushing's disease. 38
24640210 2013
123
[Clinical observation of jianpi bushen formula to prevent collapse of osteonecrosis of femoral head]. 38
24010305 2013
124
[Preliminary study of influence of bone tissue from osteonecrosis of femoral head on the proliferation and differentiation of canine bone marrow mesenchymal stem cells]. 38
23859395 2013
125
[Research progress of alcohol-induced osteonecrosis of femoral head]. 38
23672142 2013
126
Cementless modular total hip arthroplasty in patients younger than fifty with femoral head osteonecrosis: minimum fifteen-year follow-up. 38
23116541 2013
127
Clinical results of auto-iliac cancellous bone grafts combined with implantation of autologous bone marrow cells for osteonecrosis of the femoral head: a minimum 5-year follow-up. 38
23364989 2013
128
The natural history of asymptomatic osteonecrosis of the femoral head. 38
23340674 2013
129
G-CSF/SCF exert beneficial effects via anti-apoptosis in rabbits with steroid-associated osteonecrosis. 38
22750282 2013
130
An unusual complication in osteonecrosis of femoral head: a case report. 38
23401822 2013
131
Time to internal fixation of femoral neck fractures in patients under sixty years--does this matter in the development of osteonecrosis of femoral head? 38
22829122 2012
132
The cartilage degeneration and joint motion of bipolar hemiarthroplasty. 38
22588693 2012
133
Core decompression and concentrated autologous bone marrow injection for treatment of osteonecrosis of the femoral head. 38
23326977 2012
134
Inherited thrombophilia may be a causative factor for osteonecrosis of femoral head in male patients with developmental dysplasia of the hip: a case series. 38
22643805 2012
135
Third-generation ceramic-on-ceramic total hip arthroplasty in patients younger than 30 years with osteonecrosis of femoral head. 38
22153948 2012
136
Can local Erythropoietin administration enhance bone regeneration in osteonecrosis of femoral head? 38
22617757 2012
137
Effect of pentoxifylline on histopathological changes in steroid-induced osteonecrosis of femoral head: experimental study in chicken. 38
22331126 2012
138
[Research progress of gene therapy in the treatment of non-traumatic osteonecrosis of femoral head]. 38
23016397 2012
139
Osteonecrosis of femoral head treated with alendronate in a 14-year-old boy: a case report. 38
21811181 2012
140
Effects of huogu I formula (I) on correlated factors of bone regeneration in chickens with steroid-induced necrosis of femoral head. 38
22549392 2012
141
[Establishment and application of subject-specific three-dimensional finite element mesh model for osteonecrosis of femoral head]. 38
22616168 2012
142
[Research advances in experimental animal models of osteonecrosis]. 38
22737722 2012
143
Intravenous bisphosphonate therapy for children who have a traumatic fracture neck of femur and osteonecrosis: a case report. 38
22435260 2012
144
A prospective short-term outcome study of a short metaphyseal fitting total hip arthroplasty. 38
21435826 2012
145
Glucocorticoids affect the metabolism of bone marrow stromal cells and lead to osteonecrosis of the femoral head: a review. 38
22340480 2012
146
[Effects of different stress force stimulations on the expression of vascular endothelial growth factor in Beagle dogs in the repairing process of osteonecrosis of the femoral head]. 38
22490657 2012
147
[Treatment of femoral neck fractures after the fixation of ipsilateral femoral shaft by antegrade intramedullary nail]. 38
22295492 2011
148
Experimental animal models of osteonecrosis. 38
21340568 2011
149
Regeneration of human bones in hip osteonecrosis and human cartilage in knee osteoarthritis with autologous adipose-tissue-derived stem cells: a case series. 38
21736710 2011
150
[Cartilage changes of femoral head osteonecrosis in stage II and III as detected by dGEMRIC]. 38
21914282 2011
151
[Three-dimensional gait analysis of patients with osteonecrosis of femoral head before and after treatments with vascularized greater trochanter bone flap]. 38
21500576 2011
152
[Effect of different treating principles and formulas on expression of osteogenic factors in steroid-induced osteonecrosis of femoral head of chichen]. 38
21657083 2011
153
Hypoxia-inducible factor-1 is a positive regulator of Sox9 activity in femoral head osteonecrosis. 38
20950722 2011
154
Sources of adult mesenchymal stem cells applicable for musculoskeletal applications - a systematic review of the literature. 38
21886689 2011
155
Low-intensity pulsed ultrasound: a potential non-invasive therapy for femoral head osteonecrosis. 38
20826064 2011
156
Operative technique and results of core decompression and filling with bone grafts in the treatment of osteonecrosis of femoral head. 38
21273647 2010
157
Successful transplant of mesenchymal stem cells in induced osteonecrosis of the ovine femoral head: preliminary results. 38
20877951 2010
158
Increased Dickkopf-1 expression accelerates bone cell apoptosis in femoral head osteonecrosis. 38
19895917 2010
159
[Experimental study on avascular necrosis of femoral head in chickens induced by different glucocorticoides]. 38
20415073 2010
160
[Secondary total hip arthroplasty for osteonecrosis of femoral head after failed internal fixation of femoral neck fracture]. 38
20369519 2010
161
[Treatment of osteonecrosis of femoral head by core decompression combining with autologous cortical sustaining bone and cancellous bone graft]. 38
20369521 2010
162
[Metal-on-metal total hip resurfacing arthroplasty for treatment of advanced osteonecrosis of femoral head in young and middle-aged patients]. 38
20369520 2010
163
Pentosan reduces osteonecrosis of femoral head in SHRSP. 38
21091356 2010
164
The prevalence of thrombophilia in idiopathic osteonecrosis of the hip. 38
20120676 2009
165
[Treatment for osteonecrosis of femoral head by hVEGF-165 gene modified marrow stromal stem cells under arthroscope]. 38
20137681 2009
166
[Relationship between alcohol induced osteonecrosis of femoral head and single nucleotide polymorphisms of methylene tetrahydrofolate reductase 677 C/T]. 38
19817293 2009
167
Study of rotating permanent magnetic field to treat steroid-induced osteonecrosis of femoral head. 38
18204839 2009
168
[Primary outcome of impacting bone graft and fibular autograft or allograft in treating osteonecrosis of femoral head]. 38
19514570 2009
169
Fate of mesenchymal stem cells transplanted to osteonecrosis of femoral head. 38
18925660 2009
170
Local cancellous bone grafting for osteonecrosis of the femoral head. 38
19131361 2009
171
[Treatment of early osteonecrosis of femoral head by core decompression and autograft of mesenchymal stem cell cultured in vitro under arthroscopy: experiment with rabbits]. 38
19563714 2009
172
Cell therapy for avascular osteonecrosis of femoral head. 38
24693035 2009
173
Osteonecrosis of femoral head: Treatment by core decompression and vascular pedicle grafting. 38
19753176 2009
174
[Clinical significance of venous return disturbance in patients with osteonecrosis of femoral head]. 38
19253435 2009
175
[Three-D gait patterns before and after total hip arthroplasty]. 38
19563010 2009
176
[Quantitative study of therapeutic efficacy on early intervention of hyperbaric oxygen to model of steroid-induced avascular osteonecrosis of femoral head by multi-slice perfusion imaging]. 38
19171096 2008
177
Osteonecrosis of femoral head in the stroke-prone spontaneously hypertensive rats, especially old rats. 38
18855272 2008
178
Alcohol-induced multifocal osteonecrosis: a case report with 14-year follow-up. 38
18196253 2008
179
[Treatment of old femoral neck fracture in young and middle-aged patients with reconstructing femoral neck]. 38
18979870 2008
180
[Measuring blood flow change of osteonecrosis of femoral head with laser doppler flowmetry]. 38
19094684 2008
181
Association of polymorphisms in the Interleukin 23 receptor gene with osteonecrosis of femoral head in Korean population. 38
18779654 2008
182
[Progress of vascularized bone grafting for the treatment of avascular osteonecrosis of the femoral head]. 38
19102173 2008
183
Treatment of osteonecrosis of femoral head with BMSCs-seeded bio-derived bone materials combined with rhBMP-2 in rabbits. 38
18507947 2008
184
Decreased proliferation of mesenchymal stem cells in corticosteroid-induced osteonecrosis of femoral head. 38
19292322 2008
185
Changes of the bone mineral density in proximal femur following total hip resurfacing arthroplasty in osteonecrosis of femoral head. 38
17972335 2008
186
[An experimental osteonecrosis of femoral head induced by a combination of a single low-dose lipopolysaccharide and methylprednisone]. 38
18396701 2008
187
[Study on correlation between pain grading, stage of necrosis and bone marrow-edema in nontraumatic osteonecrosis of femoral head]. 38
18396706 2008
188
[Changes in bone micro-architecture and bone mineral density following experimental osteonecrosis of femoral head by local injection of ethanol in canines]. 38
18396703 2008
189
[Preliminary study on cryosurgery for osteonecrosis of femoral head in three-foot canine model]. 38
18396702 2008
190
[An experimental study on treatment of steroid-associated femoral head necrosis with simvastatin and BMSCs transplantation]. 38
18396704 2008
191
Treatment of osteonecrosis of the femoral head using autologous cultured osteoblasts: a case report. 38
18298825 2008
192
[Cage implantation for the treatment of osteonecrosis of the femoral head]. 38
18365626 2008
193
[Treatment of old femoral neck and nonunion with free vascularized fibular grafting]. 38
18510001 2008
194
MDR1(ABCB1) gene polymorphisms associated with steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus. 38
18214345 2007
195
[Postoperative functional assessment of head preserve treatment of osteonecrosis of femoral head]. 38
18261299 2007
196
Proximal femoral nail for the treatment of reverse obliquity intertrochanteric fractures compared with gamma nail. 38
17993950 2007
197
[Pathological basis for selection of therapeutic methods of osteonecrosis of femoral head]. 38
17925169 2007
198
[Treatment of osteonecrosis of femoral head with minimally invasive vascularized bone grafting]. 38
17925174 2007
199
Association study of hypoxia inducible factor 1alpha (HIF1alpha) with osteonecrosis of femoral head in a Korean population. 38
17292638 2007
200
[An experimental study on osteocyte apoptosis in steroid-induced early osteonecrosis of femoral head]. 38
17419206 2007
201
[Changes of vessel in steroid-induced osteonecrosis of femoral head: experimental study of rabbits]. 38
17064544 2006
202
[Evaluation of hemodynamic changes by digital subtraction angiography after treatment of avascular osteonecrosis of femoral head with vascularized bone flaps]. 38
16677566 2006
203
Prevention of steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus by anti-coagulant. 38
16830881 2006
204
[Preliminary experiences in minimally invasive and mini-incision surgery total hip arthroplasty for late osteonecrosis of the femoral head]. 38
16206758 2005
205
Does the self-centering mechanism of bipolar hip endoprosthesis really work in vivo? 38
15872400 2005
206
Very early development of steroid-associated osteonecrosis of femoral head in systemic lupus erythematosus: prospective study by MRI. 38
15934439 2005
207
[Treatment of osteonecrosis of femoral head with free vascularized fibula grafting]. 38
15460045 2004
208
[Avascular osteonecrosis of femoral head and neck in an AIDS patient]. 38
15628304 2004
209
Bilateral osteonecrosis of the femoral head in an adult man affected by congenital estrogen deficiency. 38
14669833 2003
210
A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. 38
14768474 2003
211
Initial changes of non-traumatic osteonecrosis of femoral head in fat suppression images: bone marrow edema was not found before the appearance of band patterns. 38
11595370 2001
212
Femoral neuropathy caused by enlarged iliopsoas bursa associated with osteonecrosis of femoral head--a case report. 38
10919308 2000
213
Hyaluronan in synovial fluid of patients with loose total hip prosthesis. Comparison with hyaluronan in patients with hip osteoarthritis and idiopathic osteonecrosis of femoral head. 38
11011673 2000
214
High incidence of osteonecrosis of femoral head in patients receiving more than 2 g of intravenous methylprednisolone after renal transplantation. 38
8658785 1996
215
[Experimental steroid osteonecrosis in rabbits and pathologic findings]. 38
8706566 1995
216
[Diagnostic value of MRI in non-traumatic osteonecrosis of femoral head at early stage]. 38
7720420 1994
217
Osteonecrosis of femoral head in SLE patient after short period of corticosteroid therapy--a case report. 38
1942485 1991
218
Drug interaction--induced osteonecrosis of femoral head. 38
2384471 1990
219
[Aseptic osteonecrosis of the femur head and pregnancy. Apropos of 2 cases with MRI study]. 38
3058958 1988
220
[Algodystrophy of the femoral head. Contribution of new imaging methods]. 38
3193387 1988
221
Vitamin D3 metabolism in idiopathic osteonecrosis of femoral head. 38
2824635 1987
222
Osteonecrosis of femoral head after topical steroid therapy. 38
3795159 1986
223
[Aseptic necrosis of the head of the femur in Cooley's disease]. 38
3704210 1986
224
[Inguinal tumor due to synovial cysts of the hip]. 38
127348 1975

Variations for Avascular Necrosis of Femoral Head, Primary, 1

ClinVar genetic disease variations for Avascular Necrosis of Femoral Head, Primary, 1:

6 (showing 8, show less)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 COL2A1 NM_001844.5(COL2A1): c.3508G> A (p.Gly1170Ser) single nucleotide variant Pathogenic rs121912891 12:48369835-48369835 12:47976052-47976052
2 COL2A1 NM_001844.5(COL2A1): c.2149G> A (p.Gly717Ser) single nucleotide variant Pathogenic rs387906558 12:48376675-48376675 12:47982892-47982892
3 COL2A1 NM_001844.5(COL2A1): c.1957C> T (p.Arg653Ter) single nucleotide variant Pathogenic rs121912893 12:48377504-48377504 12:47983721-47983721
4 COL2A1 NM_001844.5(COL2A1): c.258C> A (p.Cys86Ter) single nucleotide variant Pathogenic rs794727261 12:48393736-48393736 12:47999953-47999953
5 COL2A1 NM_001844.5(COL2A1): c.2965C> T (p.Arg989Cys) single nucleotide variant Pathogenic rs121912874 12:48372112-48372112 12:47978329-47978329
6 COL2A1 NM_001844.5(COL2A1): c.4148C> T (p.Thr1383Met) single nucleotide variant Conflicting interpretations of pathogenicity rs138498898 12:48368041-48368041 12:47974258-47974258
7 COL2A1 NM_001844.5(COL2A1): c.2618G> T (p.Gly873Val) single nucleotide variant Uncertain significance rs886042009 12:48374344-48374344 12:47980561-47980561
8 COL2A1 NM_001844.5(COL2A1): c.803C> T (p.Pro268Leu) single nucleotide variant Uncertain significance rs142770543 12:48388220-48388220 12:47994437-47994437

UniProtKB/Swiss-Prot genetic disease variations for Avascular Necrosis of Femoral Head, Primary, 1:

74 (showing 3, show less)
# Symbol AA change Variation ID SNP ID
1 COL2A1 p.Gly717Ser VAR_023929 rs387906558
2 COL2A1 p.Gly1170Ser VAR_023933 rs121912891
3 COL2A1 p.Thr1383Met VAR_075730 rs138498898

Expression for Avascular Necrosis of Femoral Head, Primary, 1

Search GEO for disease gene expression data for Avascular Necrosis of Femoral Head, Primary, 1.

Pathways for Avascular Necrosis of Femoral Head, Primary, 1

Pathways related to Avascular Necrosis of Femoral Head, Primary, 1 according to KEGG:

37 (showing 2, show less)
# Name Kegg Source Accession
1 HIF-1 signaling pathway hsa04066
2 VEGF signaling pathway hsa04370

GO Terms for Avascular Necrosis of Femoral Head, Primary, 1

Sources for Avascular Necrosis of Femoral Head, Primary, 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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