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MCID: AVN001
MIFTS: 60

Avian Influenza

Categories: Infectious diseases, Oral diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Avian Influenza

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MalaCards integrated aliases for Avian Influenza:

Name: Avian Influenza 12 60 3 15 17
Bird Flu 12 44 3
Influenza in Birds 45 74
Avian Flu 12

Characteristics:

Orphanet epidemiological data:

60
avian influenza
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Respiratory diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Rare respiratory diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:4492
MeSH 45 D005585
SNOMED-CT 69 55604004
ICD10 34 J09.X
ICD10 via Orphanet 35 J09
Orphanet 60 ORPHA454836
UMLS 74 C0016627
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Summaries for Avian Influenza

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MedlinePlus : 44 Birds, just like people, get the flu. Bird flu viruses infect birds, including chickens, other poultry, and wild birds such as ducks. Usually bird flu viruses only infect other birds. It is rare for people to get infected with bird flu viruses, but it can happen. Two types, H5N1 and H7N9, have infected some people during outbreaks in Asia, Africa, the Pacific, the Middle East, and parts of Europe. There have also been some rare cases of other types of bird flu affecting people in the United States. Most of the people who get bird flu have had close contact with infected birds or with surfaces that have been contaminated by the birds' saliva, mucous, or droppings. It is also possible to get it by breathing in droplets or dust that contain the virus. Rarely, the virus has spread from one person to another. It may also be possible to catch bird flu by eating poultry or eggs that are not well cooked. Bird flu illness in people can range from mild to severe. Often, the symptoms are similar to the seasonal flu, such as Fever Cough Sore throat Runny or stuffy nose Muscle or body aches Fatigue Headaches Eye redness (or conjunctivitis) Difficulty breathing In some cases, bird flu can cause serious complications and death. As with seasonal flu, some people are at higher risk for serious illness. They include pregnant women, people with weakened immune systems, and adults 65 and older. Treatment with antiviral medicines may make the illness less severe. They may also help prevent the flu in people who were exposed to it. There is currently no vaccine available to the public. The government does have a supply of a vaccine for one type of H5N1 bird flu virus and could distribute it if there was an outbreak that spread easily from person to person. Centers for Disease Control and Prevention

MalaCards based summary : Avian Influenza, also known as bird flu, is related to severe acute respiratory syndrome and acute respiratory distress syndrome, and has symptoms including fever, pruritus and snoring. An important gene associated with Avian Influenza is FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme), and among its related pathways/superpathways are Innate Immune System and PAK Pathway. The drugs Oseltamivir and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and eye, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has material basis in Influenza A virus, which is transmitted by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.

CDC : 3 Avian influenza refers to the disease caused by infection with avian (bird) influenza (flu) Type A viruses. These viruses occur naturally among wild aquatic birds worldwide and can infect domestic poultry and other bird and animal species. Avian flu viruses do not normally infect humans. However, sporadic human infections with avian flu viruses have occurred. The links below offer more information about avian influenza.

Wikipedia : 77 Avian influenza—known informally as avian flu or bird flu is a variety of influenza caused by viruses... more...

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Related Diseases for Avian Influenza

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Diseases related to Avian Influenza via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 severe acute respiratory syndrome 31.1 CXCL10 CXCL8 TNF
2 acute respiratory distress syndrome 30.6 CXCL8 IL6 SFTPD TNF
3 pneumonia 30.4 CXCL8 IL6 SFTPD TNF
4 swine influenza 30.3 HAS1 NEU1 TNF
5 japanese encephalitis 30.2 CXCL10 DDX58 TNF
6 leptospirosis 30.1 CXCL8 IL6 TNF
7 adult respiratory distress syndrome 30.1 CXCL8 IL6 TNF
8 measles 30.1 DDX58 IL6 STAT2
9 chlamydia 30.1 CXCL8 IL6 TNF
10 intestinal disease 30.0 CXCL8 IL6 TNF
11 respiratory failure 30.0 CXCL8 SFTPD TNF
12 bacterial pneumonia 29.9 CXCL8 IL6 SFTPD
13 human immunodeficiency virus type 1 29.6 CCR1 CXCL10 IL6 TNF
14 malaria 29.5 CXCL10 CXCL8 IL6 PCSK6 TNF
15 influenza 11.6
16 newcastle disease 10.9
17 bronchitis 10.5
18 scorpion envenomation 10.4 IL6 TNF
19 exudative glomerulonephritis 10.4 CXCL8 TNF
20 recurrent corneal erosion 10.4 CXCL8 IL6
21 leukomalacia 10.4 IL6 TNF
22 bagassosis 10.4 CXCL8 IL6
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
24 autoimmune myocarditis 10.3 IL6 TNF
25 critical limb ischemia 10.3 IL6 TNF
26 acute transverse myelitis 10.3 CXCL8 IL6
27 tungiasis 10.3 CXCL8 TNF
28 viral meningitis 10.3 CXCL10 CXCL8 IL6
29 acute pyelonephritis 10.3 CXCL10 CXCL8 IL6
30 crimean-congo hemorrhagic fever 10.3 CXCL10 IL6 TNF
31 stromal keratitis 10.3 CXCL10 IL6 TNF
32 chikungunya 10.3 DDX58 IL6 TNF
33 juvenile ankylosing spondylitis 10.3 IL6 TNF
34 paracoccidioidomycosis 10.3 CXCL10 IL6 TNF
35 cardiogenic shock 10.3 IL6 TNF
36 neurosyphilis 10.3 CXCL10 CXCL8
37 bacterial infectious disease 10.3 CXCL8 IL6 TNF
38 streptococcal toxic-shock syndrome 10.3 CXCL8 IL6 TNF
39 glaucomatocyclitic crisis 10.3 CXCL10 CXCL8 TNF
40 meconium aspiration syndrome 10.3 CXCL8 IL6 TNF
41 louse-borne relapsing fever 10.3 CXCL8 IL6 TNF
42 endometrial disease 10.3 CXCL8 IL6 TNF
43 transverse myelitis 10.3 CXCL8 IL6 TNF
44 conjunctivitis 10.3
45 meningitis 10.3 CXCL8 IL6 TNF
46 autoimmune disease of central nervous system 10.3 CXCL10 IL6 TNF
47 pulpitis 10.3 CXCL8 IL6 TNF
48 middle ear disease 10.3 CXCL8 IL6 TNF
49 pyelonephritis 10.3 CXCL8 IL6 TNF
50 perinatal necrotizing enterocolitis 10.3 CXCL8 IL6 TNF

Graphical network of the top 20 diseases related to Avian Influenza:



Diseases related to Avian Influenza
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Symptoms & Phenotypes for Avian Influenza

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UMLS symptoms related to Avian Influenza:


fever, pruritus, snoring, coughing

MGI Mouse Phenotypes related to Avian Influenza:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 CCR1 CRK CXCL10 FURIN IL6 NEU1
2 hematopoietic system MP:0005397 10 CCR1 CXCL10 DDX58 FURIN IL6 IRF7
3 digestive/alimentary MP:0005381 9.92 CCR1 CRK DDX58 FURIN IL6 PCSK5
4 immune system MP:0005387 9.9 CCR1 CXCL10 DDX58 FURIN IL6 IRF7
5 mortality/aging MP:0010768 9.77 CCR1 CRK CXCL10 DDX58 FURIN IL6
6 respiratory system MP:0005388 9.23 CCR1 CRK IL6 NEU1 PCSK5 PCSK6
Sources

Drugs & Therapeutics for Avian Influenza

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Drugs for Avian Influenza (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oseltamivir Approved Phase 4,Phase 2,Phase 3,Phase 1 204255-11-8, 196618-13-0 65028
2
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 5284616 6436030
3
Everolimus Approved Phase 4 159351-69-6 70789204 6442177
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
6 Aluminum phosphate Phase 4
7 Vaccines Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
8 Immunosuppressive Agents Phase 4,Phase 3
9 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
10 Antiviral Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Antibiotics, Antitubercular Phase 4
12 Anti-Bacterial Agents Phase 4
13 Antifungal Agents Phase 4
14
Formaldehyde Approved, Vet_approved Phase 2, Phase 3 50-00-0 712
15
Aluminum hydroxide Approved, Investigational Phase 2, Phase 3,Phase 1 21645-51-2
16
Lactitol Investigational Phase 3,Phase 2,Phase 1 585-88-6, 585-86-4 493591
17 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
18 MF59 oil emulsion Phase 3,Phase 2,Phase 1
19 Hemagglutinins Phase 3,Phase 2,Phase 1
20 Antibodies Phase 3,Phase 2,Phase 1
21 Immunoglobulins Phase 3,Phase 2,Phase 1
22 Agglutinins Phase 3,Phase 1,Phase 2
23 Cathartics Phase 3
24 Laxatives Phase 3
25 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
26
Aluminum sulfate Approved Phase 2,Phase 1 10043-01-3
27
Zanamivir Approved, Investigational Phase 2,Phase 1 139110-80-8 60855
28
Tocopherol Approved, Investigational Phase 2 1406-66-2 14986
29
Dopamine Approved Phase 2 62-31-7, 51-61-6 681
30
Amantadine Approved Phase 2 768-94-5 2130
31
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
32 Tocotrienol Investigational Phase 2 6829-55-6
33 Adjuvants, Immunologic Phase 2,Phase 1
34 Antacids Phase 1, Phase 2,Phase 2
35 Anti-Ulcer Agents Phase 1, Phase 2,Phase 2
36 Tocopherols Phase 2
37 Tocotrienols Phase 2
38 interferons Phase 1, Phase 2
39 Interferon Inducers Phase 1, Phase 2
40 Rho(D) Immune Globulin Phase 2
41 Immunoglobulins, Intravenous Phase 2
42 gamma-Globulins Phase 2
43 Dopamine Agents Phase 2
44 Analgesics Phase 2
45 Analgesics, Non-Narcotic Phase 2
46 Neurotransmitter Agents Phase 2
47 Antiparkinson Agents Phase 2
48 Peripheral Nervous System Agents Phase 2
49 Poly I-C Phase 1, Phase 2
50 poly(I).poly(c12,U) Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 235)
# Name Status NCT ID Phase Drugs
1 Comparison of the Cellular and the Humoral Immunogenicity, Safety of Different Trivalent Influenza Vaccines Unknown status NCT01119157 Phase 4
2 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
3 Immunogenicity and Safety of PrepandrixTM in Korean Subjects Aged 18 to 60 Years Old Completed NCT01730378 Phase 4
4 The Immunogenicity and Safety of 2013-2014 Seasonal Trivalent Influenza Vaccine Completed NCT02269852 Phase 4
5 Durability and Impact of the Seasonal Influenza Vaccine on H5 Induced B Cell Response Recruiting NCT03701061 Phase 4
6 Adjunctive Sirolimus and Oseltamivir Versus Oseltamivir Alone for Treatment of Influenza Not yet recruiting NCT03901001 Phase 4 sirolimus and oseltamivir;Oseltamivir
7 A Safety and Immunogenicity Study of IVACFLU-A/H5N1 Completed NCT02612909 Phase 2, Phase 3
8 Monovalent H5N1 Vaccine GSK1557484A in Children 6 Months to < 18 Years of Age Completed NCT01310413 Phase 3
9 H5N1 Vaccine Study in Japanese Adults Completed NCT01382329 Phase 2, Phase 3
10 A Study to Evaluate Safety, Immunogenicity, and Lot-to-Lot Consistency of H5N1 Subunit Influenza Virus Vaccine in Healthy Adult Subjects ≥18 Years of Age Completed NCT02839330 Phase 3
11 Safety and Tolerability Study of GlaxoSmithKline (GSK)1557484A Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure Completed NCT01788228 Phase 3
12 Immunogenicity, Safety and Tolerability of Two Doses of FLUAD-H5N1 Influenza Vaccine in Adult and Elderly Subjects Completed NCT00434733 Phase 3
13 Phase 3 Study of a H5N1 Vaccine in Adults, Elderly and Specified Risk Groups Completed NCT00711295 Phase 3
14 Japanese Pediatric H5N1 Vaccine Study Completed NCT01911754 Phase 3
15 H5N1 Vaccine Study in Japanese Elderly Population Aged 65 Years and Older Completed NCT01774032 Phase 3
16 Phase 3 Immunogenicity and Safety Study of an Inactivated H5N1 Influenza Vaccine (Whole Virion, Vero Cell Derived) Completed NCT00462215 Phase 3
17 Safety and Immunogenicity of Two Doses of Monovalent Inactivated Influenza Vaccine That is Adjuvanted With MF59C.1 (MF59) and Uses a Surface Antigen From a Potential Pandemic Virus Strain Candidate (H5N1) in Adult and Elderly Subjects Using Four Different Vaccination Schedules Completed NCT00848029 Phase 3
18 Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Immunosuppressive Conditions *aH5N1:Monovalent H5N1 Influenza Vaccine Completed NCT02107807 Phase 3
19 Phase III Study to Evaluate the Immunogenicity and Safety of MG1109 in Healthy Adult Volunteers Completed NCT01987011 Phase 3
20 Study to Evaluate the Safety and Immunogenicity of a Pandemic Influenza Vaccine in Adults Aged 18 Years and Above Completed NCT00319098 Phase 3
21 Safety, Tolerability and Immunogenicity of Two Doses of Adjuvanted Monovalent Influenza Vaccine Administered to Healthy Adult and Elderly Subjects Completed NCT00841763 Phase 3
22 Immunogenicity & Safety of GSK's Influenza Vaccine 1557484A Given to Adults Aged ≥18 Years Completed NCT00616928 Phase 3
23 Immunogenicity of GSK Biologicals' Pandemic Influenza Vaccine (GSK1562902A) at Different Boosting Vaccination Schedules Completed NCT00652743 Phase 3
24 A Study to Evaluate the Safety and Immunogenicity of a Prime-boost Schedule of GSK Biologicals' Influenza Vaccine in Children Completed NCT01379937 Phase 3
25 A Study for Evaluation of GSK Biologicals' Pandemic Influenza Vaccine. Completed NCT00812981 Phase 3
26 Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Underlying Medical Conditions Completed NCT02091908 Phase 3
27 Immunogenicity and Safety of an Adjuvanted Inactivated Subunit Influenza Vaccine to Those of a Non-adjuvanted Inactivated Subunit Influenza Vaccine, When Administered to Adults Affected by Chronic Diseases Completed NCT00519064 Phase 3
28 Oseltamivir for Influenza Lower Respiratory Tract Infection in Children Under One Withdrawn NCT01546935 Phase 2, Phase 3 Oseltamivir
29 Inactivated Influenza A/H5N1 Vaccine in Adult Subjects at Risk of Occupational Exposure to Live H5N1 Viruses Unknown status NCT00417560 Phase 1, Phase 2
30 Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection Unknown status NCT02095444 Phase 1, Phase 2 Menstrual blood stem cells
31 Systems Biology of Influenza A (H5N1) Virus Monovalent Vaccine With and Without Adjuvant System 03 (AS03) Completed NCT01910519 Phase 2
32 H7N9 Mix and Match With MF59 in Healthy Elderly Persons Completed NCT02213354 Phase 2 MF59
33 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Healthy Adults Completed NCT01776541 Phase 2
34 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Elderly Subjects Completed NCT01766921 Phase 2
35 Safety and Immunogenicity of a Booster Dose of -H5N1 Influenza Vaccine Completed NCT00561184 Phase 2
36 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Adults Unprimed and Primed With Adjuvanted or Non-adjuvanted Influenza Vaccines Completed NCT00478816 Phase 2
37 H7N9 Boost in Healthy Adults Completed NCT02586792 Phase 2
38 Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 Years Completed NCT00537524 Phase 2
39 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Children Completed NCT01776554 Phase 2
40 Safety and Immunogenicity of Two Doses, Administered Three Weeks Apart, of Two Monovalent H5N1 Influenza Vaccines Containing 2 Doses of H5N1 Influenza Antigen, in Non-elderly Adult and Elderly Subjects Completed NCT00914771 Phase 2
41 H5N1 (Clade 2) Vaccination of Adults and Elderly Completed NCT00680069 Phase 1, Phase 2
42 H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses Completed NCT02921997 Phase 2 AS03
43 Immunogenicity and Safety Study of a Booster Vaccination With a Recombinant H5N1 Influenza HA Vaccine in Primed Adults Completed NCT01195038 Phase 2
44 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Monovalent Pandemic H5N1 Vaccine in Adults Completed NCT01416571 Phase 2
45 Inactivated Influenza A/H5N1 Vaccine in the Elderly Completed NCT00230750 Phase 1, Phase 2 Placebo
46 A/H5N1 Vaccine in Healthy Children Aged 2-9 Years Completed NCT00133536 Phase 1, Phase 2 Placebo
47 Assess the Safety & Immunogenicity of Stored Inactivated Influenza H5N1 Virus Vaccine Given With & Without Stored MF59 Adjuvant Completed NCT02680002 Phase 2
48 Safety, Reactogenicity and Immunogenicity of an H5N1 VLP Completed NCT00519389 Phase 1, Phase 2
49 H7N9 Mix and Match With MF59 in Healthy Adults Completed NCT01938742 Phase 2 MF59
50 High-Dose Versus Standard-Dose Oseltamivir to Treat Severe Influenza and Avian Influenza Completed NCT00298233 Phase 2 Oseltamivir

Search NIH Clinical Center for Avian Influenza

Cochrane evidence based reviews: influenza in birds

Sources

Genetic Tests for Avian Influenza

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Anatomical Context for Avian Influenza

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MalaCards organs/tissues related to Avian Influenza:

42
Lung, Testes, Eye, T Cells, B Cells, Brain, Endothelial
Sources

Publications for Avian Influenza

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Articles related to Avian Influenza:

(show top 50) (show all 3439)
# Title Authors Year
1
Veno-venous extracorporeal membrane oxygenation for patient with a history of open cholecystectomy and acute respiratory distress syndrome caused by coinfection of avian influenza A (H7N9) and Epstein-Barr virus. ( 30985312 )
2019
2
The codon usage bias of avian influenza A viruses. ( 31075292 )
2019
3
Contaminated feed-borne Bacillus cereus aggravates respiratory distress post avian influenza virus H9N2 infection by inducing pneumonia. ( 31076729 )
2019
4
Virulence of three European highly pathogenic H7N1 and H7N7 avian influenza viruses in Pekin and Muscovy ducks. ( 31077209 )
2019
5
Mutations in PB2 and HA enhanced pathogenicity of H4N6 avian influenza virus in mice. ( 31081750 )
2019
6
Profiling the TRB and IGH repertoire of patients with H5N6 Avian Influenza Virus Infection by high-throughput sequencing. ( 31092835 )
2019
7
A hospital cluster combined with a family cluster of avian influenza H7N9 infection in Anhui Province, China. ( 31100362 )
2019
8
Transmission Risk of Avian Influenza Virus along Poultry Supply Chains in Guangdong, China. ( 31100365 )
2019
9
PB2 and hemagglutinin mutations confer a virulent phenotype on an H1N2 avian influenza virus in mice. ( 31111259 )
2019
10
B cell epitopes in the intrinsically disordered regions of neuraminidase and hemagglutinin proteins of H5N1 and H9N2 avian influenza viruses for peptide-based vaccine development. ( 31111560 )
2019
11
Characterization of a novel reassortant H7N3 highly pathogenic avian influenza virus isolated from a poultry meat product taken on a passenger flight to Japan. ( 30674734 )
2019
12
Clinical indices and mortality of hospitalized avian influenza A (H7N9) patients in Guangdong, China. ( 30681496 )
2019
13
Digital Single Virus Immunoassay for Ultrasensitive Multiplex Avian Influenza Virus Detection Based on Fluorescent Magnetic Multifunctional Nanospheres. ( 30688060 )
2019
14
Heterosubtypic protection against avian influenza virus by live attenuated and chimeric norovirus P-particle-M2e vaccines in chickens. ( 30691981 )
2019
15
Spatial modelling for low pathogenicity avian influenza virus at the interface of wild birds and backyard poultry. ( 30698918 )
2019
16
Molecular characterization and receptor binding specificity of H9N2 avian influenza viruses based on poultry-related environmental surveillance in China between 2013 and 2016. ( 30703577 )
2019
17
Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets. ( 30705346 )
2019
18
The development of a multiplex serological assay for avian influenza based on Luminex technology. ( 30707951 )
2019
19
Continuous adaptation of the HA and NA gene of H3N2 subtypes of avian influenza virus in South China, 2017-2018. ( 30710556 )
2019
20
Sensitive fluorometric determination of platelet-derived growth factor BB and avian influenza A virus DNA via dual signal amplification using the hybridization chain reaction and glucose oxidase assisted recycling. ( 30712102 )
2019
21
Ultrasensitive detection of avian influenza A (H7N9) virus using surface-enhanced Raman scattering-based lateral flow immunoassay strips. ( 30712559 )
2019
22
Surveillance for avian influenza viruses in wild birds at live bird markets, Egypt, 2014-2016. ( 30714323 )
2019
23
Comparative pathogenicity of H5N6 subtype highly pathogenic avian influenza viruses in chicken, Pekin duck and Muscovy duck. ( 30720248 )
2019
24
Soluble expression, rapid purification, biological identification of chicken interferon-alpha using a thioredoxin fusion system in E. coli and its antiviral effects to H9N2 avian influenza virus. ( 30734625 )
2019
25
Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. ( 30737282 )
2019
26
Shedding of clade 2.3.4.4 H5N8 and H5N2 highly pathogenic avian influenza viruses in peridomestic wild birds in the U.S. ( 30740920 )
2019
27
Estimating Risk to Responders Exposed to Avian Influenza A H5 and H7 Viruses in Poultry, United States, 2014-2017. ( 30741630 )
2019
28
Different pathogenicity of two strains of clade 2.3.4.4c H5N6 highly pathogenic avian influenza viruses bearing different PA and NS gene in domestic ducks. ( 30753976 )
2019
29
An avian influenza virus A(H7N9) reassortant that recently emerged in the United States with low pathogenic phenotype does not efficiently infect swine. ( 30761746 )
2019
30
Pathogenicity and Transmissibility of North American H7 Low Pathogenic Avian Influenza Viruses in Chickens and Turkeys. ( 30781528 )
2019
31
MicroRNA expression profiles from HEK293 cells expressing H5N1 avian influenza virus non-structural protein 1. ( 30782044 )
2019
32
Human exposures to H5N6 Avian influenza, England, 2018. ( 30788504 )
2019
33
Reassortments among Avian Influenza A(H5N1) Viruses Circulating in Indonesia, 2015-2016. ( 30789142 )
2019
34
Correction: Assessing the probability of introduction and spread of avian influenza (AI) virus in commercial Australian poultry operations using an expert opinion elicitation. ( 30789945 )
2019
35
Multiplex one-step real-time PCR assay for rapid simultaneous detection of velogenic and mesogenic Newcastle disease virus and H5-subtype avian influenza virus. ( 30790106 )
2019
36
Correction: Risk of poultry compartments for transmission of Highly Pathogenic Avian Influenza. ( 30794712 )
2019
37
Recombinant H5 hemagglutinin adjuvanted with nanoemulsion protects ferrets against pathogenic avian influenza virus challenge. ( 30795941 )
2019
38
Enhanced cross-lineage protection induced by recombinant H9N2 avian influenza virus inactivated vaccine. ( 30797637 )
2019
39
Spatiotemporal Variation and Hotspot Detection of the Avian Influenza A(H7N9) Virus in China, 2013⁻2017. ( 30813229 )
2019
40
In Vivo Characterization of Avian Influenza A (H5N1) and (H7N9) Viruses Isolated from Canadian Travelers. ( 30813415 )
2019
41
Avian influenza viruses at the wild-domestic bird interface in Egypt. ( 30815236 )
2019
42
Reverse vaccinology approach to design a novel multi-epitope subunit vaccine against avian influenza A (H7N9) virus. ( 30822457 )
2019
43
Modelling high pathogenic avian influenza outbreaks in the commercial poultry industry. ( 30825417 )
2019
44
Direct visualization of avian influenza H5N1 Hemagglutinin precursor and its conformational change by high-speed atomic force microscopy. ( 30825615 )
2019
45
Chicken anaemia virus enhances and prolongs subsequent avian influenza (H9N2) and infectious bronchitis viral infections. ( 30827377 )
2019
46
Integration of a 3D-printed read-out platform with a quantum dot-based immunoassay for detection of the avian influenza A (H7N9) virus. ( 30830133 )
2019
47
Epidemiological Features of Highly Pathogenic Avian Influenza in Cameroon. ( 30834103 )
2019
48
A Systematic Evaluation of Measures Against Highly Pathogenic Avian Influenza (HPAI) in Indonesia. ( 30834252 )
2019
49
A review of H5Nx avian influenza viruses. ( 30834359 )
2019
50
CRISPR-Cas13a Nanomachine Based Simple Technology for Avian Influenza A (H7N9) Virus On-Site Detection. ( 30841971 )
2019
Sources

Variations for Avian Influenza

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Expression for Avian Influenza

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Search GEO for disease gene expression data for Avian Influenza.
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Pathways for Avian Influenza

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Pathways related to Avian Influenza according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.94 CCR1 CRK CXCL10 CXCL8 DDX58 IL6
2
PAK Pathway 65
Show member pathways
 13.21 CCR1 CRK CXCL10 CXCL8 IL6 TNF
3
Cytokine Signaling in Immune system 67
Show member pathways
 13.02 CCR1 CRK CXCL10 CXCL8 DDX58 IL6
4
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 12.85 CXCL10 CXCL8 IL6 IRF7 SFTPD STAT2
5
CCR5 Pathway in Macrophages 65
Show member pathways
 12.77 CCR1 CRK CXCL10 CXCL8 STAT2
6
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.58 CXCL10 CXCL8 DDX58 IL6 IRF7 TNF
7
Human cytomegalovirus infection 38
Show member pathways
 12.55 CCR1 CRK CXCL8 DDX58 IL6 IRF7
8
NF-kappaB Signaling 4
12.41 CXCL10 DDX58 IRF7 STAT2 TNF
9
IL-17 Family Signaling Pathways 66
Show member pathways
 12.22 CXCL10 CXCL8 IL6 TNF
10
Toll Comparative Pathway 65
Show member pathways
 12.21 CRK CXCL8 IL6 TNF
11
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.14 CXCL8 IL6 IRF7 TNF
12
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.12 CXCL8 IL6 IRF7 STAT2 TNF
13
Bacterial infections in CF airways 23
Show member pathways
 11.94 CXCL10 CXCL8 IL6 SFTPD TNF
14
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 66
Show member pathways
 11.9 CCR1 CXCL10 CXCL8
15
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.9 CCR1 IL6 TNF
16
Interleukin-4 and 13 signaling 67
11.89 CXCL8 IL6 TNF
17
TNF signaling pathway 38
11.87 CXCL10 IL6 TNF
18
Spinal Cord Injury 1
11.86 CXCL10 CXCL8 IL6 TNF
19
Senescence and Autophagy in Cancer 1
11.85 CXCL8 IL6 IRF7
20
AGE-RAGE signaling pathway in diabetic complications 38
11.81 CXCL8 IL6 TNF
21
NF-kappa B signaling pathway 38
11.8 CXCL8 DDX58 TNF
22
Jak-Stat Signaling Pathway (sino) 68
11.79 CCR1 IL6 STAT2
23
Amoebiasis 38
11.79 CXCL8 IL6 TNF
24
Rheumatoid arthritis 38
11.76 CXCL8 IL6 TNF
25
Pertussis 38
11.66 CXCL8 IL6 TNF
26
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.63 CXCL10 IL6 TNF
27
LPA receptor mediated events 1
11.58 CRK CXCL8 IL6
28
Lung fibrosis 1
11.55 CXCL8 IL6 TNF
29
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.54 CXCL8 IL6 TNF
30
Legionellosis 38
11.46 CXCL8 IL6 TNF
31
Malaria 38
11.39 CXCL8 IL6 TNF
32
G-protein signaling_RhoB regulation pathway 23
11.07 CXCL10 CXCL8 IL6 TNF
33
Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics 62
Show member pathways
 10.99 DDX58 IRF7 STAT2
34
Overview of nanoparticle effects 1
10.86 CXCL8 IL6 TNF
35
Interleukin-10 signaling 67
10.71 CCR1 CXCL10 CXCL8 IL6 TNF
36
NGF processing 67
Show member pathways
 9.83 FURIN PCSK5 PCSK6
Sources

GO Terms for Avian Influenza

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Cellular components related to Avian Influenza according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CXCL10 CXCL8 FURIN IL6 PCSK5 PCSK6
2 Golgi lumen GO:0005796 9.33 FURIN PCSK5 PCSK6
3 extracellular region GO:0005576 9.28 CXCL10 CXCL8 FURIN IL6 NEU1 PCSK5

Biological processes related to Avian Influenza according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CCR1 CXCL10 CXCL8 IL6 TNF
2 inflammatory response GO:0006954 9.85 CCR1 CXCL10 CXCL8 IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.78 CXCL10 CXCL8 IL6 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.77 DDX58 IL6 TNF
5 chemokine-mediated signaling pathway GO:0070098 9.71 CCR1 CXCL10 CXCL8
6 positive regulation of interleukin-6 production GO:0032755 9.7 DDX58 IL6 TNF
7 protein processing GO:0016485 9.67 FURIN PCSK5 PCSK6
8 response to virus GO:0009615 9.67 CXCL10 DDX58 IRF7 TNF
9 positive regulation of monocyte chemotaxis GO:0090026 9.61 CCR1 CXCL10
10 positive regulation of glial cell proliferation GO:0060252 9.61 IL6 TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 FURIN TNF
12 positive regulation of interferon-alpha production GO:0032727 9.58 DDX58 IRF7
13 signal peptide processing GO:0006465 9.58 FURIN PCSK5
14 secretion by cell GO:0032940 9.57 FURIN PCSK6
15 negative regulation of lipid storage GO:0010888 9.56 IL6 TNF
16 defense response to virus GO:0051607 9.55 CXCL10 DDX58 IL6 IRF7 STAT2
17 positive regulation of neuroinflammatory response GO:0150078 9.51 IL6 TNF
18 peptide hormone processing GO:0016486 9.5 FURIN PCSK5 PCSK6
19 peptide biosynthetic process GO:0043043 9.43 FURIN PCSK5
20 embryonic digestive tract development GO:0048566 9.43 CXCL8 PCSK5 TNF
21 nerve growth factor production GO:0032902 9.4 FURIN PCSK6
22 cytokine-mediated signaling pathway GO:0019221 9.17 CCR1 CRK CXCL10 CXCL8 IL6 STAT2
23 regulation of lipoprotein lipase activity GO:0051004 9.13 FURIN PCSK5 PCSK6

Molecular functions related to Avian Influenza according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 BCL2L10 CCR1 CRK CXCL10 CXCL8 DDX58
2 cytokine activity GO:0005125 9.46 CXCL10 CXCL8 IL6 TNF
3 endopeptidase activity GO:0004175 9.43 FURIN PCSK5 PCSK6
4 nerve growth factor binding GO:0048406 8.96 FURIN PCSK6
Sources

Sources for Avian Influenza

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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