Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: AVN001
MIFTS: 57

Avian Influenza

Categories: Respiratory diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Avian Influenza

About this section

MalaCards integrated aliases for Avian Influenza:

Name: Avian Influenza 12 59 3 15
Bird Flu 12 43 3
Influenza in Birds 44 73
Avian Flu 12

Characteristics:

Orphanet epidemiological data:

59
avian influenza
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare respiratory diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:4492
ICD10 33 J09.X
MeSH 44 D005585
SNOMED-CT 68 55604004
Orphanet 59 ORPHA454836
ICD10 via Orphanet 34 J09
UMLS 73 C0016627
Sources

Summaries for Avian Influenza

About this section
MedlinePlus : 43 Birds, just like people, get the flu. Bird flu viruses infect birds, including chickens, other poultry, and wild birds such as ducks. Usually bird flu viruses only infect other birds. It is rare for people to get infected with bird flu viruses, but it can happen. Two types, H5N1 and H7N9, have infected some people during outbreaks in Asia, Africa, the Pacific, the Middle East, and parts of Europe. There have also been some rare cases of other types of bird flu affecting people in the United States. Most of the people who get bird flu have had close contact with infected birds or with surfaces that have been contaminated by the birds' saliva, mucous, or droppings. It is also possible to get it by breathing in droplets or dust that contain the virus. Rarely, the virus has spread from one person to another. It may also be possible to catch bird flu by eating poultry or eggs that are not well cooked. Bird flu illness in people can range from mild to severe. Often, the symptoms are similar to the seasonal flu, such as Fever Cough Sore throat Runny or stuffy nose Muscle or body aches Fatigue Headaches Eye redness (or conjunctivitis) Difficulty breathing In some cases, bird flu can cause serious complications and death. As with seasonal flu, some people are at higher risk for serious illness. They include pregnant women, people with weakened immune systems, and seniors aged 65 and older. Treatment with antiviral medicines may make the illness less severe. They may also help prevent the flu in people who were exposed to it. There is currently no vaccine available to the public. The government does have a supply of a vaccine for one type of H5N1 bird flu virus and could distribute it if there was an outbreak that spread easily from person to person. Centers for Disease Control and Prevention

MalaCards based summary : Avian Influenza, also known as bird flu, is related to severe acute respiratory syndrome and japanese encephalitis, and has symptoms including coughing, fever and pruritus. An important gene associated with Avian Influenza is FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme), and among its related pathways/superpathways are PAK Pathway and Cytokine Signaling in Immune system. The drugs Aluminum phosphate and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and lung, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has material basis in Influenza A virus, which is transmitted by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.

CDC : 3 Avian influenza refers to the disease caused by infection with avian (bird) influenza (flu) Type A viruses. These viruses occur naturally among wild aquatic birds worldwide and can infect domestic poultry and other bird and animal species. Avian flu viruses do not normally infect humans. However, sporadic human infections with avian flu viruses have occurred. The links below offer more information about avian influenza.

Wikipedia : 76 Avian influenza—known informally as avian flu or bird flu is a variety of influenza caused by viruses... more...

Sources

Related Diseases for Avian Influenza

About this section

Diseases related to Avian Influenza via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 severe acute respiratory syndrome 30.9 CXCL10 CXCL8 TNF
2 japanese encephalitis 30.5 CXCL10 DDX58 TNF
3 leptospirosis 30.4 CXCL8 IL6 TNF
4 adult respiratory distress syndrome 30.4 CXCL8 IL6 TNF
5 chlamydia 30.3 CXCL8 IL6 TNF
6 intestinal disease 30.3 CXCL8 IL6 TNF
7 swine influenza 30.1 HAS1 TNF
8 pneumonia 29.9 CXCL8 IL6 SFTPD TNF
9 acute respiratory distress syndrome 29.7 CXCL8 IL6 SFTPD TNF
10 respiratory failure 29.7 CXCL8 SFTPD TNF
11 malaria 29.2 CXCL10 CXCL8 IL6 PCSK6 TNF
12 influenza 11.2
13 scorpion envenomation 10.8 IL6 TNF
14 recurrent corneal erosion 10.8 CXCL8 IL6
15 bagassosis 10.8 CXCL8 IL6
16 leukomalacia 10.7 IL6 TNF
17 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
18 acute transverse myelitis 10.7 CXCL8 IL6
19 critical limb ischemia 10.7 IL6 TNF
20 tungiasis 10.7 CXCL8 TNF
21 neurosyphilis 10.7 CXCL10 CXCL8
22 null-cell leukemia 10.6 IL6 TNF
23 acute pyelonephritis 10.6 CXCL10 CXCL8 IL6
24 viral meningitis 10.6 CXCL10 CXCL8 IL6
25 crimean-congo hemorrhagic fever 10.6 CXCL10 IL6 TNF
26 stromal keratitis 10.6 CXCL10 IL6 TNF
27 chikungunya 10.6 DDX58 IL6 TNF
28 newcastle disease 10.6
29 denture stomatitis 10.6 CXCL8 IL6
30 paracoccidioidomycosis 10.6 CXCL10 IL6 TNF
31 retinitis pigmentosa 55 10.6 IL6 TNF
32 papillary conjunctivitis 10.6 CXCL8 IL6
33 streptococcal toxic-shock syndrome 10.6 CXCL8 IL6 TNF
34 meconium aspiration syndrome 10.6 CXCL8 IL6 TNF
35 louse-borne relapsing fever 10.6 CXCL8 IL6 TNF
36 transverse myelitis 10.6 CXCL8 IL6 TNF
37 cytomegalovirus infection 10.6 CXCL8 IL6 TNF
38 pulpitis 10.6 CXCL8 IL6 TNF
39 perinatal necrotizing enterocolitis 10.5 CXCL8 IL6 TNF
40 fasciitis 10.5 CXCL8 IL6 TNF
41 uterine anomalies 10.5 CXCL8 IL6 TNF
42 primary bacterial infectious disease 10.5 CXCL10 IL6 TNF
43 prostatitis 10.5 CXCL8 IL6 TNF
44 bacterial vaginosis 10.5 CXCL8 IL6 TNF
45 brucellosis 10.5 CXCL8 IL6 TNF
46 pyelonephritis 10.5 CXCL8 IL6 TNF
47 appendicitis 10.5 CXCL8 IL6 TNF
48 tonsillitis 10.5 CXCL8 IL6 TNF
49 aggressive periodontitis 10.5 CXCL8 IL6 TNF
50 anca-associated vasculitis 10.5 IL6 TNF

Graphical network of the top 20 diseases related to Avian Influenza:



Diseases related to Avian Influenza
Sources

Symptoms & Phenotypes for Avian Influenza

About this section

UMLS symptoms related to Avian Influenza:


coughing, fever, pruritus, snoring

MGI Mouse Phenotypes related to Avian Influenza:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 SFTPD STAT2 TNF CCR1 CXCL10 DDX58
2 digestive/alimentary MP:0005381 9.92 CCR1 CRK DDX58 FURIN IL6 PCSK5
3 immune system MP:0005387 9.85 CCR1 CXCL10 DDX58 FURIN IL6 IRF7
4 mortality/aging MP:0010768 9.73 CCR1 CRK CXCL10 DDX58 FURIN IL6
5 respiratory system MP:0005388 9.17 CCR1 CRK IL6 PCSK5 PCSK6 SFTPD
Sources

Drugs & Therapeutics for Avian Influenza

About this section

Drugs for Avian Influenza (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Aluminum phosphate Phase 4
2 Vaccines Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
3
Formaldehyde Approved, Vet_approved Phase 2, Phase 3,Phase 1 50-00-0 712
4
Aluminum hydroxide Approved, Investigational Phase 2, Phase 3,Phase 1 21645-51-2
5
Oseltamivir Approved Phase 2, Phase 3,Phase 1 204255-11-8, 196618-13-0 65028
6
Lactitol Investigational Phase 3,Phase 2,Phase 1 585-86-4 3871
7 Hemagglutinins Phase 3,Phase 1,Phase 2
8 Cathartics Phase 3
9 MF59 oil emulsion Phase 3,Phase 2,Phase 1,Not Applicable
10 Agglutinins Phase 3,Phase 1,Phase 2
11 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
12 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
13 Antibodies Phase 3,Phase 2,Phase 1
14 Immunoglobulins Phase 3,Phase 2,Phase 1
15 Immunosuppressive Agents Phase 3
16 Anti-Infective Agents Phase 2, Phase 3,Phase 1
17 Laxatives Phase 3
18 Antiviral Agents Phase 2, Phase 3,Phase 1
19
Zanamivir Approved, Investigational Phase 2,Phase 1 139110-80-8 60855
20
Aluminum sulfate Approved Phase 2,Phase 1 10043-01-3
21
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
22
Amantadine Approved Phase 2 768-94-5 2130
23 Adjuvants, Immunologic Phase 2,Phase 1,Not Applicable
24 Antacids Phase 1, Phase 2,Phase 2
25 Anti-Ulcer Agents Phase 1, Phase 2,Phase 2
26 Analgesics Phase 2
27 interferons Phase 1, Phase 2
28 Rho(D) Immune Globulin Phase 2
29 gamma-Globulins Phase 2
30 Neurotransmitter Agents Phase 2
31 Analgesics, Non-Narcotic Phase 2
32 Dopamine Agents Phase 2
33 Peripheral Nervous System Agents Phase 2
34 Immunoglobulins, Intravenous Phase 2
35 Poly I-C Phase 1, Phase 2
36 poly(I).poly(c12,U) Phase 1, Phase 2
37 Interferon Inducers Phase 1, Phase 2
38 Antiparkinson Agents Phase 2
39
Peramivir Approved, Investigational Phase 1 229614-55-5, 330600-85-6 151164
40
Probenecid Approved, Investigational Phase 1 57-66-9 4911
41
Inulin Approved, Investigational, Nutraceutical Phase 1 9005-80-5 24763
42 Renal Agents Phase 1
43 Anti-Bacterial Agents Phase 1
44 Antibiotics, Antitubercular Phase 1
45 ISCOMs Phase 1
46 Antirheumatic Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 223)
# Name Status NCT ID Phase Drugs
1 Comparison of the Cellular and the Humoral Immunogenicity, Safety of Different Trivalent Influenza Vaccines Unknown status NCT01119157 Phase 4
2 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
3 Immunogenicity and Safety of PrepandrixTM in Korean Subjects Aged 18 to 60 Years Old Completed NCT01730378 Phase 4
4 The Immunogenicity and Safety of 2013-2014 Seasonal Trivalent Influenza Vaccine Completed NCT02269852 Phase 4
5 A Safety and Immunogenicity Study of IVACFLU-A/H5N1 Unknown status NCT02612909 Phase 2, Phase 3
6 Monovalent H5N1 Vaccine GSK1557484A in Children 6 Months to < 18 Years of Age Completed NCT01310413 Phase 3
7 H5N1 Vaccine Study in Japanese Adults Completed NCT01382329 Phase 2, Phase 3
8 A Study to Evaluate Safety, Immunogenicity, and Lot-to-Lot Consistency of H5N1 Subunit Influenza Virus Vaccine in Healthy Adult Subjects ≥18 Years of Age Completed NCT02839330 Phase 3
9 Safety and Tolerability Study of GlaxoSmithKline (GSK)1557484A Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure Completed NCT01788228 Phase 3
10 Immunogenicity, Safety and Tolerability of Two Doses of FLUAD-H5N1 Influenza Vaccine in Adult and Elderly Subjects Completed NCT00434733 Phase 3
11 Phase 3 Study of a H5N1 Vaccine in Adults, Elderly and Specified Risk Groups Completed NCT00711295 Phase 3
12 Japanese Pediatric H5N1 Vaccine Study Completed NCT01911754 Phase 3
13 H5N1 Vaccine Study in Japanese Elderly Population Aged 65 Years and Older Completed NCT01774032 Phase 3
14 Phase 3 Immunogenicity and Safety Study of an Inactivated H5N1 Influenza Vaccine (Whole Virion, Vero Cell Derived) Completed NCT00462215 Phase 3
15 Safety and Immunogenicity of Two Doses of Monovalent Inactivated Influenza Vaccine That is Adjuvanted With MF59C.1 (MF59) and Uses a Surface Antigen From a Potential Pandemic Virus Strain Candidate (H5N1) in Adult and Elderly Subjects Using Four Different Completed NCT00848029 Phase 3
16 Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Immunosuppressive Conditions *aH5N1:Monovalent H5N1 Influenza Vaccine Completed NCT02107807 Phase 3
17 Phase III Study to Evaluate the Immunogenicity and Safety of MG1109 in Healthy Adult Volunteers Completed NCT01987011 Phase 3
18 Study to Evaluate the Safety and Immunogenicity of a Pandemic Influenza Vaccine in Adults Aged 18 Years and Above Completed NCT00319098 Phase 3
19 Safety, Tolerability and Immunogenicity of Two Doses of Adjuvanted Monovalent Influenza Vaccine Administered to Healthy Adult and Elderly Subjects Completed NCT00841763 Phase 3
20 Immunogenicity & Safety of GSK's Influenza Vaccine 1557484A Given to Adults Aged ≥18 Years Completed NCT00616928 Phase 3
21 A Study to Evaluate the Safety and Immunogenicity of a Prime-boost Schedule of GSK Biologicals' Influenza Vaccine in Children Completed NCT01379937 Phase 3
22 A Study for Evaluation of GSK Biologicals' Pandemic Influenza Vaccine. Completed NCT00812981 Phase 3
23 Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Underlying Medical Conditions Completed NCT02091908 Phase 3
24 Immunogenicity of GSK Biologicals' Pandemic Influenza Vaccine (GSK1562902A) at Different Boosting Vaccination Schedules Completed NCT00652743 Phase 3
25 Immunogenicity and Safety of an Adjuvanted Inactivated Subunit Influenza Vaccine to Those of a Non-adjuvanted Inactivated Subunit Influenza Vaccine, When Administered to Adults Affected by Chronic Diseases Completed NCT00519064 Phase 3
26 Oseltamivir for Influenza Lower Respiratory Tract Infection in Children Under One Withdrawn NCT01546935 Phase 2, Phase 3 Oseltamivir
27 Inactivated Influenza A/H5N1 Vaccine in Adult Subjects at Risk of Occupational Exposure to Live H5N1 Viruses Unknown status NCT00417560 Phase 1, Phase 2
28 Immunogenicity and Safety of Pandemic Influenza Vaccine in Healthy Adults Unknown status NCT01640691 Phase 1, Phase 2
29 Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection Unknown status NCT02095444 Phase 1, Phase 2 Menstrual blood stem cells
30 H7N9 Mix and Match With MF59 in Healthy Elderly Persons Completed NCT02213354 Phase 2 MF59
31 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Healthy Adults Completed NCT01776541 Phase 2
32 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Elderly Subjects Completed NCT01766921 Phase 2
33 Safety and Immunogenicity of a Booster Dose of -H5N1 Influenza Vaccine Completed NCT00561184 Phase 2
34 Systems Biology of Influenza A (H5N1) Virus Monovalent Vaccine With and Without Adjuvant System 03 (AS03) Completed NCT01910519 Phase 2
35 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Adults Unprimed and Primed With Adjuvanted or Non-adjuvanted Influenza Vaccines Completed NCT00478816 Phase 2
36 Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 Years Completed NCT00537524 Phase 2
37 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Children Completed NCT01776554 Phase 2
38 Safety and Immunogenicity of Two Doses, Administered Three Weeks Apart, of Two Monovalent H5N1 Influenza Vaccines Containing 2 Doses of H5N1 Influenza Antigen, in Non-elderly Adult and Elderly Subjects Completed NCT00914771 Phase 2
39 H5N1 (Clade 2) Vaccination of Adults and Elderly Completed NCT00680069 Phase 1, Phase 2
40 H7N9 Boost in Healthy Adults Completed NCT02586792 Phase 2
41 H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses Completed NCT02921997 Phase 2 AS03
42 Immunogenicity and Safety Study of a Booster Vaccination With a Recombinant H5N1 Influenza HA Vaccine in Primed Adults Completed NCT01195038 Phase 2
43 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Monovalent Pandemic H5N1 Vaccine in Adults Completed NCT01416571 Phase 2
44 Inactivated Influenza A/H5N1 Vaccine in the Elderly Completed NCT00230750 Phase 1, Phase 2 Placebo
45 A/H5N1 Vaccine in Healthy Children Aged 2-9 Years Completed NCT00133536 Phase 1, Phase 2 Placebo
46 Assess the Safety & Immunogenicity of Stored Inactivated Influenza H5N1 Virus Vaccine Given With & Without Stored MF59 Adjuvant Completed NCT02680002 Phase 2
47 H7N9 Mix and Match With MF59 in Healthy Adults Completed NCT01938742 Phase 2 MF59
48 Safety, Reactogenicity and Immunogenicity of an H5N1 VLP Completed NCT00519389 Phase 1, Phase 2
49 High-Dose Versus Standard-Dose Oseltamivir to Treat Severe Influenza and Avian Influenza Completed NCT00298233 Phase 2 Oseltamivir
50 A Trial to Test the Response to Different Vaccination Regimens With an H5N1 Vaccine With AS03 in Adults Aged 18-64 Completed NCT00695669 Phase 2

Search NIH Clinical Center for Avian Influenza

Cochrane evidence based reviews: influenza in birds

Sources

Genetic Tests for Avian Influenza

About this section
Sources

Anatomical Context for Avian Influenza

About this section

MalaCards organs/tissues related to Avian Influenza:

41
Eye, Testes, Lung, T Cells, B Cells, Trachea, Myeloid
Sources

Publications for Avian Influenza

About this section

Articles related to Avian Influenza:

(show top 50) (show all 803)
# Title Authors Year
1
Scoring Amino Acid Mutations to Predict Avian-to-Human Transmission of Avian Influenza Viruses. ( 29966263 )
2018
2
Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt. ( 29946159 )
2018
3
The PA-interacting host protein nucleolin acts as an antiviral factor during highly pathogenic H5N1 avian influenza virus infection. ( 29974255 )
2018
4
Human Infection with Avian Influenza A(H7N2) Virus - Virginia, 2002. ( 29430844 )
2018
5
Novel Highly Pathogenic Avian Influenza A(H5N6) Virus in the Netherlands, December 2017. ( 29381134 )
2018
6
Assessment of human-to-human transmissibility of avian influenza A(H7N9) virus across five waves by analyzing clusters of case-patients in mainland China, 2013-2017. ( 29961834 )
2018
7
Discrimination of Avian Influenza Virus Subtypes using Host-Cell Infection Fingerprinting by a Sulfinate-based Fluorescence Superoxide Probe. ( 29933516 )
2018
8
Spatio-temporal patterns of highly pathogenic avian influenza virus subtype H5N8 spread, France, 2016 to 2017. ( 29970219 )
2018
9
Erratum: Author Correction: Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus. ( 29799537 )
2018
10
Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. ( 29410395 )
2018
11
Global avian influenza outbreaks 2010-2016: a systematic review of their distribution, avian species and virus subtype. ( 29368637 )
2018
12
Viral interference between low pathogenic avian influenza H9N2 and avian infectious bronchitis viruses in vitro and in ovo. ( 29940196 )
2018
13
Cottontail rabbits shed clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses. ( 29948379 )
2018
14
Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses. ( 29386534 )
2018
15
Prolonged evolution of virus-specific memory T cell immunity post severe avian influenza A (H7N9) virus infection. ( 29925664 )
2018
16
Unlocking pandemic potential: prevalence and spatial patterns of key substitutions in avian influenza H5N1 in Egyptian isolates. ( 29980172 )
2018
17
A rapid and transient innate immune response to avian influenza infection in mallards. ( 29407578 )
2018
18
Spatial transmission of H5N6 highly pathogenic avian influenza viruses among wild birds in Ibaraki Prefecture, Japan, 2016-2017. ( 29392495 )
2018
19
Identification of high risk areas for avian influenza outbreaks in California using disease distribution models. ( 29385158 )
2018
20
Avian Influenza Virus Surveillance in High Arctic Breeding Geese, Greenland. ( 29944408 )
2018
21
Sudden emergence of human infections with H7N9 avian influenza A virus in Hubei province, central China. ( 29410505 )
2018
22
Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools. ( 29970470 )
2018
23
Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017. ( 29382414 )
2018
24
Induction of immune response in chickens primed in ovo with an inactivated H9N2 avian influenza virus vaccine. ( 29970157 )
2018
25
Phylogenetic classification of hemagglutinin gene of H9N2 avian influenza viruses isolated in China during 2012-2016 and evaluation of selected candidate vaccine strains. ( 29931183 )
2018
26
Characterization of avian influenza H9N2 viruses isolated from ostriches (Struthio camelus). ( 29396439 )
2018
27
Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. ( 29438519 )
2018
28
Avian influenza prevention zone extended. ( 29374112 )
2018
29
Genetic and biological characterization of H9N2 avian influenza viruses isolated in China from 2011 to 2014. ( 29969454 )
2018
30
Avian Influenza Virus Subtype H9N2 Affects Intestinal Microbiota, Barrier Structure Injury, and Inflammatory Intestinal Disease in the Chicken Ileum. ( 29783653 )
2018
31
Epidemiological and genetic characteristics of the fifth avian influenza A(H7N9) wave in Suzhou, China, from october 2016 to april 2017. ( 29404897 )
2018
32
Bactericidal and virucidal efficacies of potassium monopersulfate and its application for inactivating avian influenza virus on virus-spiked clothes. ( 29434116 )
2018
33
The Application of NHEJ-CRISPR/Cas9 and Cre-Lox System in the Generation of Bivalent Duck Enteritis Virus Vaccine against Avian Influenza Virus. ( 29438322 )
2018
34
Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration. ( 29310581 )
2018
35
Broad-spectrum neutralization of avian influenza viruses by sialylated human milk oligosaccharides: in vivo assessment of 3'-sialyllactose against H9N2 in chickens. ( 29416087 )
2018
36
Avian influenza virus ecology and evolution through a climatic lens. ( 29980049 )
2018
37
Avian influenza surveillance in domestic waterfowl and environment of live bird markets in Bangladesh, 2007-2012. ( 29925854 )
2018
38
Protecting poultry from avian influenza. ( 29419504 )
2018
39
Similar transmissibility of the Italian H7N1 highly pathogenic avian influenza virus and its low pathogenic avian influenza virus predecessor. ( 29428086 )
2018
40
Expert Elicitation Provides a Rapid Alternative to Formal Case-Control Study of an H7N9 Avian Influenza Outbreak in the United States. ( 29944401 )
2018
41
Multi-antigen avian influenza a (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models. ( 28061848 )
2017
42
Novel reassortant clade 2.3.4.4 avian influenza A (H5N8) virus in a grey heron in South Korea in 2017. ( 28900762 )
2017
43
Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016-2017. ( 28892736 )
2017
44
Current situation of H9N2 subtype avian influenza in China. ( 28915920 )
2017
45
Pathogenesis, Transmissibility, and Tropism of a Highly Pathogenic Avian Influenza A(H7N7) Virus Associated With Human Conjunctivitis in Italy, 2013. ( 28934452 )
2017
46
Estimating Risks of Inapparent Avian Exposure for Human Infection: Avian Influenza Virus A (H7N9) in Zhejiang Province, China. ( 28054599 )
2017
47
Quantifying predictors for the spatial diffusion of avian influenza virus in China. ( 28086751 )
2017
48
Highly Pathogenic Avian Influenza H5N8 Clade 2.3.4.4b in Germany in 2016/2017. ( 29417053 )
2017
49
Highly Pathogenic Avian Influenza A(H5N1) Viruses at the Animal-Human Interface in Vietnam, 2003-2010. ( 28934457 )
2017
50
Protective efficacy of combined trivalent inactivated ISA 71 oil adjuvant vaccine against avian influenza virus subtypes (H9N2 and H5N1) and Newcastle disease virus. ( 29184367 )
2017
Sources

Variations for Avian Influenza

About this section
Sources

Expression for Avian Influenza

About this section
Search GEO for disease gene expression data for Avian Influenza.
Sources

Pathways for Avian Influenza

About this section

Pathways related to Avian Influenza according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
PAK Pathway 64
Show member pathways
 13.19 CCR1 CRK CXCL10 CXCL8 IL6 TNF
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.13 CCR1 CRK CXCL10 CXCL8 DDX58 IL6
3
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.83 CXCL10 CXCL8 IL6 IRF7 SFTPD STAT2
4
CCR5 Pathway in Macrophages 64
Show member pathways
 12.76 CCR1 CRK CXCL10 CXCL8 STAT2
5
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.62 CXCL10 CXCL8 DDX58 IL6 IRF7 TNF
6
Regulation of IFNA signaling 66
Show member pathways
 12.52 CXCL8 IL6 IRF7 STAT2 TNF
7
NF-kappaB Signaling 4
12.45 CXCL10 DDX58 IRF7 STAT2 TNF
8
Influenza A 37
Show member pathways
 12.25 CXCL10 CXCL8 DDX58 FURIN IL6 IRF7
9
IL-17 Family Signaling Pathways 65
Show member pathways
 12.22 CXCL10 CXCL8 IL6 TNF
10
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.22 CCR1 CXCL8 DDX58 IL6 IRF7 STAT2
11
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.14 CXCL8 IL6 IRF7 TNF
12
Bacterial infections in CF airways 22
Show member pathways
 12.02 CXCL10 CXCL8 IL6 SFTPD TNF
13
Adipogenesis 1
11.96 IL6 STAT2 TNF
14
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 11.9 CCR1 CXCL10 CXCL8
15
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.9 CCR1 IL6 TNF
16
Spinal Cord Injury 1
11.89 CXCL10 CXCL8 IL6 TNF
17
Interleukin-4 and 13 signaling 66
11.88 CXCL8 IL6 TNF
18
TNF signaling pathway 37
11.85 CXCL10 IL6 TNF
19
Senescence and Autophagy in Cancer 1
11.84 CXCL8 IL6 IRF7
20
Hepatitis C 37
11.84 CXCL8 DDX58 IRF7 STAT2 TNF
21
AGE-RAGE signaling pathway in diabetic complications 37
11.8 CXCL8 IL6 TNF
22
Amoebiasis 37
11.79 CXCL8 IL6 TNF
23
NF-kappa B signaling pathway 37
11.78 CXCL8 DDX58 TNF
24
Rheumatoid arthritis 37
11.75 CXCL8 IL6 TNF
25
Pertussis 37
11.66 CXCL8 IL6 TNF
26
LPA receptor mediated events 1
11.59 CRK CXCL8 IL6
27
Lung fibrosis 1
11.56 CXCL8 IL6 TNF
28
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.55 CXCL8 IL6 TNF
29
Legionellosis 37
11.48 CXCL8 IL6 TNF
30
Malaria 37
11.41 CXCL8 IL6 TNF
31
Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics 61
Show member pathways
 11.03 DDX58 IRF7 STAT2
32
Overview of nanoparticle effects 1
10.91 CXCL8 IL6 TNF
33
Interleukin-10 signaling 66
10.71 CCR1 CXCL10 CXCL8 IL6 TNF
34
NGF processing 66
Show member pathways
 10.13 FURIN PCSK5 PCSK6
Sources

GO Terms for Avian Influenza

About this section

Cellular components related to Avian Influenza according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CXCL10 CXCL8 FURIN IL6 PCSK5 PCSK6
2 extracellular space GO:0005615 9.23 CXCL10 CXCL8 FURIN IL6 PCSK5 PCSK6
3 Golgi lumen GO:0005796 9.13 FURIN PCSK5 PCSK6

Biological processes related to Avian Influenza according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.93 CCR1 CXCL10 CXCL8 IL6 TNF
2 inflammatory response GO:0006954 9.91 CCR1 CXCL10 CXCL8 IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.78 CXCL10 CXCL8 IL6 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.77 DDX58 IL6 TNF
5 chemokine-mediated signaling pathway GO:0070098 9.73 CCR1 CXCL10 CXCL8
6 response to virus GO:0009615 9.73 CXCL10 DDX58 IRF7 TNF
7 protein processing GO:0016485 9.72 FURIN PCSK5 PCSK6
8 positive regulation of interleukin-6 production GO:0032755 9.7 DDX58 IL6 TNF
9 defense response to virus GO:0051607 9.65 CXCL10 DDX58 IL6 IRF7 STAT2
10 positive regulation of osteoclast differentiation GO:0045672 9.62 CCR1 TNF
11 positive regulation of chemokine production GO:0032722 9.61 IL6 TNF
12 positive regulation of monocyte chemotaxis GO:0090026 9.61 CCR1 CXCL10
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 FURIN TNF
14 positive regulation of interferon-alpha production GO:0032727 9.58 DDX58 IRF7
15 secretion by cell GO:0032940 9.58 FURIN PCSK6
16 positive regulation of leukocyte chemotaxis GO:0002690 9.58 CXCL10 CXCL8 IL6
17 negative regulation of lipid storage GO:0010888 9.57 IL6 TNF
18 peptide hormone processing GO:0016486 9.54 FURIN PCSK5 PCSK6
19 embryonic digestive tract development GO:0048566 9.5 CXCL8 PCSK5 TNF
20 peptide biosynthetic process GO:0043043 9.49 FURIN PCSK5
21 nerve growth factor production GO:0032902 9.46 FURIN PCSK6
22 regulation of lipoprotein lipase activity GO:0051004 9.33 FURIN PCSK5 PCSK6
23 cytokine-mediated signaling pathway GO:0019221 9.17 CCR1 CRK CXCL10 CXCL8 IL6 STAT2
24 nerve growth factor processing GO:0032455 9.13 FURIN PCSK5 PCSK6

Molecular functions related to Avian Influenza according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.33 FURIN PCSK5 PCSK6
2 CXCR chemokine receptor binding GO:0045236 9.26 CXCL10 CXCL8
3 cytokine activity GO:0005125 9.26 CXCL10 CXCL8 IL6 TNF
4 nerve growth factor binding GO:0048406 8.62 FURIN PCSK6
Sources

Sources for Avian Influenza

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....