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MCID: AVN001
MIFTS: 58

Avian Influenza

Categories: Infectious diseases, Oral diseases, Rare diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Avian Influenza

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MalaCards integrated aliases for Avian Influenza:

Name: Avian Influenza 12 59 3 15
Bird Flu 12 43 3
Influenza in Birds 44 73
Avian Flu 12

Characteristics:

Orphanet epidemiological data:

59
avian influenza
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Respiratory diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare respiratory diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:4492
ICD10 33 J09.X
MeSH 44 D005585
SNOMED-CT 68 55604004
Orphanet 59 ORPHA454836
ICD10 via Orphanet 34 J09
UMLS 73 C0016627
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Summaries for Avian Influenza

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MedlinePlus : 43 Birds, just like people, get the flu. Bird flu viruses infect birds, including chickens, other poultry, and wild birds such as ducks. Usually bird flu viruses only infect other birds. It is rare for people to get infected with bird flu viruses, but it can happen. Two types, H5N1 and H7N9, have infected some people during outbreaks in Asia, Africa, the Pacific, the Middle East, and parts of Europe. There have also been some rare cases of other types of bird flu affecting people in the United States. Most of the people who get bird flu have had close contact with infected birds or with surfaces that have been contaminated by the birds' saliva, mucous, or droppings. It is also possible to get it by breathing in droplets or dust that contain the virus. Rarely, the virus has spread from one person to another. It may also be possible to catch bird flu by eating poultry or eggs that are not well cooked. Bird flu illness in people can range from mild to severe. Often, the symptoms are similar to the seasonal flu, such as Fever Cough Sore throat Runny or stuffy nose Muscle or body aches Fatigue Headaches Eye redness (or conjunctivitis) Difficulty breathing In some cases, bird flu can cause serious complications and death. As with seasonal flu, some people are at higher risk for serious illness. They include pregnant women, people with weakened immune systems, and seniors aged 65 and older. Treatment with antiviral medicines may make the illness less severe. They may also help prevent the flu in people who were exposed to it. There is currently no vaccine available to the public. The government does have a supply of a vaccine for one type of H5N1 bird flu virus and could distribute it if there was an outbreak that spread easily from person to person. Centers for Disease Control and Prevention

MalaCards based summary : Avian Influenza, also known as bird flu, is related to influenza and viral infectious disease, and has symptoms including fever, pruritus and snoring. An important gene associated with Avian Influenza is FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme), and among its related pathways/superpathways are PAK Pathway and Cytokine Signaling in Immune system. The drugs Aluminum phosphate and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include testes, eye and lung, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has material basis in Influenza A virus, which is transmitted by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has symptom fever, has symptom cough, has symptom sore throat, has symptom muscle aches, has symptom nausea, has symptom diarrhea, has symptom vomiting, has symptom neurologic changes, has symptom pneumonia, and has symptom acute respiratory distress.

CDC : 3 Avian influenza refers to the disease caused by infection with avian (bird) influenza (flu) Type A viruses. These viruses occur naturally among wild aquatic birds worldwide and can infect domestic poultry and other bird and animal species. Avian flu viruses do not normally infect humans. However, sporadic human infections with avian flu viruses have occurred. The links below offer more information about avian influenza.

Wikipedia : 76 Avian influenza�??known informally as avian flu or bird flu is a variety of influenza caused by viruses... more...

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Related Diseases for Avian Influenza

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Diseases related to Avian Influenza via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 influenza 32.4 CXCL10 DDX58 FURIN IRF7
2 viral infectious disease 30.8 CXCL10 CXCL8 DDX58 IL6 IRF7 TNF
3 severe acute respiratory syndrome 30.8 CXCL10 CXCL8 TNF
4 acute respiratory distress syndrome 30.3 CXCL8 IL6 SFTPD TNF
5 chlamydia 30.2 CXCL8 IL6 TNF
6 pneumonia 30.2 CXCL8 IL6 SFTPD TNF
7 japanese encephalitis 30.0 CXCL10 DDX58 TNF
8 leptospirosis 30.0 CXCL8 IL6 TNF
9 adult respiratory distress syndrome 30.0 CXCL8 IL6 TNF
10 intestinal disease 29.9 CXCL8 IL6 TNF
11 bacterial pneumonia 29.9 CXCL8 IL6 SFTPD
12 measles 29.9 DDX58 IL6 STAT2
13 respiratory failure 29.8 CXCL8 SFTPD TNF
14 malaria 29.6 CXCL10 CXCL8 IL6 PCSK6 TNF
15 newcastle disease 10.8
16 bronchitis 10.4
17 scorpion envenomation 10.3 IL6 TNF
18 exudative glomerulonephritis 10.2 CXCL8 TNF
19 recurrent corneal erosion 10.2 CXCL8 IL6
20 leukomalacia 10.2 IL6 TNF
21 bagassosis 10.2 CXCL8 IL6
22 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
23 acute transverse myelitis 10.2 CXCL8 IL6
24 critical limb ischemia 10.2 IL6 TNF
25 tungiasis 10.2 CXCL8 TNF
26 juvenile ankylosing spondylitis 10.2 IL6 TNF
27 cardiogenic shock 10.2 IL6 TNF
28 neurosyphilis 10.2 CXCL10 CXCL8
29 viral meningitis 10.2 CXCL10 CXCL8 IL6
30 acute pyelonephritis 10.2 CXCL10 CXCL8 IL6
31 crimean-congo hemorrhagic fever 10.2 CXCL10 IL6 TNF
32 stromal keratitis 10.2 CXCL10 IL6 TNF
33 chikungunya 10.2 DDX58 IL6 TNF
34 swine influenza 10.2
35 null-cell leukemia 10.2 IL6 TNF
36 viral encephalitis 10.2 CXCL10 IL6 TNF
37 paracoccidioidomycosis 10.2 CXCL10 IL6 TNF
38 bacterial infectious disease 10.2 CXCL8 IL6 TNF
39 streptococcal toxic-shock syndrome 10.2 CXCL8 IL6 TNF
40 glaucomatocyclitic crisis 10.2 CXCL10 CXCL8 TNF
41 meconium aspiration syndrome 10.2 CXCL8 IL6 TNF
42 louse-borne relapsing fever 10.2 CXCL8 IL6 TNF
43 endometrial disease 10.2 CXCL8 IL6 TNF
44 retinitis pigmentosa 55 10.2 IL6 TNF
45 denture stomatitis 10.2 CXCL8 IL6
46 transverse myelitis 10.2 CXCL8 IL6 TNF
47 meningitis 10.2 CXCL8 IL6 TNF
48 autoimmune disease of central nervous system 10.2 CXCL10 IL6 TNF
49 pulpitis 10.2 CXCL8 IL6 TNF
50 middle ear disease 10.2 CXCL8 IL6 TNF

Graphical network of the top 20 diseases related to Avian Influenza:



Diseases related to Avian Influenza
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Symptoms & Phenotypes for Avian Influenza

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UMLS symptoms related to Avian Influenza:


fever, pruritus, snoring, coughing

MGI Mouse Phenotypes related to Avian Influenza:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 CCR1 CXCL10 DDX58 FURIN IL6 IRF7
2 digestive/alimentary MP:0005381 9.92 CCR1 CRK DDX58 FURIN IL6 PCSK5
3 immune system MP:0005387 9.85 CCR1 CXCL10 DDX58 FURIN IL6 IRF7
4 mortality/aging MP:0010768 9.73 CCR1 CRK CXCL10 DDX58 FURIN IL6
5 respiratory system MP:0005388 9.17 CCR1 CRK IL6 PCSK5 PCSK6 SFTPD
Sources

Drugs & Therapeutics for Avian Influenza

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Drugs for Avian Influenza (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Aluminum phosphate Phase 4
2 Vaccines Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
3 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
4
Aluminum hydroxide Approved, Investigational Phase 2, Phase 3,Phase 1 21645-51-2
5
Formaldehyde Approved, Vet_approved Phase 2, Phase 3,Phase 1 50-00-0 712
6
Oseltamivir Approved Phase 2, Phase 3,Phase 1 204255-11-8, 196618-13-0 65028
7
Lactitol Investigational Phase 3,Phase 2,Phase 1 585-86-4 3871
8 Pharmaceutical Solutions Phase 3,Phase 1,Phase 2
9 Hemagglutinins Phase 3,Phase 2,Phase 1
10 MF59 oil emulsion Phase 3,Phase 2,Phase 1
11 Immunoglobulins Phase 3,Phase 2,Phase 1
12 Antibodies Phase 3,Phase 2,Phase 1
13 Agglutinins Phase 3,Phase 1,Phase 2
14 Laxatives Phase 3
15 Gastrointestinal Agents Phase 3,Phase 1,Phase 2
16 Cathartics Phase 3
17 Immunosuppressive Agents Phase 3
18 Anti-Infective Agents Phase 2, Phase 3,Phase 1
19 Antiviral Agents Phase 2, Phase 3,Phase 1
20
Aluminum sulfate Approved Phase 2,Phase 1 10043-01-3
21
Zanamivir Approved, Investigational Phase 2,Phase 1 139110-80-8 60855
22
Amantadine Approved Phase 2 768-94-5 2130
23
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
24 Adjuvants, Immunologic Phase 2,Phase 1
25 Antacids Phase 1, Phase 2,Phase 2
26 Anti-Ulcer Agents Phase 1, Phase 2,Phase 2
27 Interferon Inducers Phase 1, Phase 2
28 interferons Phase 1, Phase 2
29 gamma-Globulins Phase 2
30 Immunoglobulins, Intravenous Phase 2
31 Rho(D) Immune Globulin Phase 2
32 Peripheral Nervous System Agents Phase 2
33 Analgesics Phase 2
34 Neurotransmitter Agents Phase 2
35 Antiparkinson Agents Phase 2
36 Analgesics, Non-Narcotic Phase 2
37 Dopamine Agents Phase 2
38 poly(I).poly(c12,U) Phase 1, Phase 2
39 Poly I-C Phase 1, Phase 2
40
Probenecid Approved, Investigational Phase 1 57-66-9 4911
41
Peramivir Approved, Investigational Phase 1 229614-55-5, 330600-85-6 151164
42
Imiquimod Approved, Investigational Phase 1 99011-02-6 57469
43
Inulin Approved, Investigational, Nutraceutical Phase 1 9005-80-5 24763
44 Anti-Bacterial Agents Phase 1
45 Antibiotics, Antitubercular Phase 1
46 ISCOMs Phase 1
47 Renal Agents Phase 1
48 Antirheumatic Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 232)
# Name Status NCT ID Phase Drugs
1 Comparison of the Cellular and the Humoral Immunogenicity, Safety of Different Trivalent Influenza Vaccines Unknown status NCT01119157 Phase 4
2 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
3 Immunogenicity and Safety of PrepandrixTM in Korean Subjects Aged 18 to 60 Years Old Completed NCT01730378 Phase 4
4 The Immunogenicity and Safety of 2013-2014 Seasonal Trivalent Influenza Vaccine Completed NCT02269852 Phase 4
5 Durability and Impact of the Seasonal Influenza Vaccine on H5 Induced B Cell Response Recruiting NCT03701061 Phase 4
6 A Safety and Immunogenicity Study of IVACFLU-A/H5N1 Unknown status NCT02612909 Phase 2, Phase 3
7 Monovalent H5N1 Vaccine GSK1557484A in Children 6 Months to < 18 Years of Age Completed NCT01310413 Phase 3
8 H5N1 Vaccine Study in Japanese Adults Completed NCT01382329 Phase 2, Phase 3
9 A Study to Evaluate Safety, Immunogenicity, and Lot-to-Lot Consistency of H5N1 Subunit Influenza Virus Vaccine in Healthy Adult Subjects ≥18 Years of Age Completed NCT02839330 Phase 3
10 Safety and Tolerability Study of GlaxoSmithKline (GSK)1557484A Vaccine in Adults at Occupational Risk for Influenza A (H5N1) Exposure Completed NCT01788228 Phase 3
11 Immunogenicity, Safety and Tolerability of Two Doses of FLUAD-H5N1 Influenza Vaccine in Adult and Elderly Subjects Completed NCT00434733 Phase 3
12 Phase 3 Study of a H5N1 Vaccine in Adults, Elderly and Specified Risk Groups Completed NCT00711295 Phase 3
13 Japanese Pediatric H5N1 Vaccine Study Completed NCT01911754 Phase 3
14 H5N1 Vaccine Study in Japanese Elderly Population Aged 65 Years and Older Completed NCT01774032 Phase 3
15 Phase 3 Immunogenicity and Safety Study of an Inactivated H5N1 Influenza Vaccine (Whole Virion, Vero Cell Derived) Completed NCT00462215 Phase 3
16 Safety and Immunogenicity of Two Doses of Monovalent Inactivated Influenza Vaccine That is Adjuvanted With MF59C.1 (MF59) and Uses a Surface Antigen From a Potential Pandemic Virus Strain Candidate (H5N1) in Adult and Elderly Subjects Using Four Different Vaccination Schedules Completed NCT00848029 Phase 3
17 Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Immunosuppressive Conditions *aH5N1:Monovalent H5N1 Influenza Vaccine Completed NCT02107807 Phase 3
18 Phase III Study to Evaluate the Immunogenicity and Safety of MG1109 in Healthy Adult Volunteers Completed NCT01987011 Phase 3
19 Study to Evaluate the Safety and Immunogenicity of a Pandemic Influenza Vaccine in Adults Aged 18 Years and Above Completed NCT00319098 Phase 3
20 Safety, Tolerability and Immunogenicity of Two Doses of Adjuvanted Monovalent Influenza Vaccine Administered to Healthy Adult and Elderly Subjects Completed NCT00841763 Phase 3
21 Immunogenicity & Safety of GSK's Influenza Vaccine 1557484A Given to Adults Aged ≥18 Years Completed NCT00616928 Phase 3
22 Immunogenicity of GSK Biologicals' Pandemic Influenza Vaccine (GSK1562902A) at Different Boosting Vaccination Schedules Completed NCT00652743 Phase 3
23 A Study to Evaluate the Safety and Immunogenicity of a Prime-boost Schedule of GSK Biologicals' Influenza Vaccine in Children Completed NCT01379937 Phase 3
24 A Study for Evaluation of GSK Biologicals' Pandemic Influenza Vaccine. Completed NCT00812981 Phase 3
25 Safety and Immunogenicity of Two Doses of aH5N1 Vaccine in Adult and Elderly Subjects With and Without Underlying Medical Conditions Completed NCT02091908 Phase 3
26 Immunogenicity and Safety of an Adjuvanted Inactivated Subunit Influenza Vaccine to Those of a Non-adjuvanted Inactivated Subunit Influenza Vaccine, When Administered to Adults Affected by Chronic Diseases Completed NCT00519064 Phase 3
27 Oseltamivir for Influenza Lower Respiratory Tract Infection in Children Under One Withdrawn NCT01546935 Phase 2, Phase 3 Oseltamivir
28 Inactivated Influenza A/H5N1 Vaccine in Adult Subjects at Risk of Occupational Exposure to Live H5N1 Viruses Unknown status NCT00417560 Phase 1, Phase 2
29 Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection Unknown status NCT02095444 Phase 1, Phase 2 Menstrual blood stem cells
30 H7N9 Mix and Match With MF59 in Healthy Elderly Persons Completed NCT02213354 Phase 2 MF59
31 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Healthy Adults Completed NCT01776541 Phase 2
32 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Elderly Subjects Completed NCT01766921 Phase 2
33 Safety and Immunogenicity of a Booster Dose of -H5N1 Influenza Vaccine Completed NCT00561184 Phase 2
34 Systems Biology of Influenza A (H5N1) Virus Monovalent Vaccine With and Without Adjuvant System 03 (AS03) Completed NCT01910519 Phase 2
35 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Adults Unprimed and Primed With Adjuvanted or Non-adjuvanted Influenza Vaccines Completed NCT00478816 Phase 2
36 H7N9 Boost in Healthy Adults Completed NCT02586792 Phase 2
37 Immunogenicity, Safety and Tolerability of Two Doses of a Pre-pandemic Influenza Vaccine in Participants Aged 6 Months to 17 Years Completed NCT00537524 Phase 2
38 Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Children Completed NCT01776554 Phase 2
39 Safety and Immunogenicity of Two Doses, Administered Three Weeks Apart, of Two Monovalent H5N1 Influenza Vaccines Containing 2 Doses of H5N1 Influenza Antigen, in Non-elderly Adult and Elderly Subjects Completed NCT00914771 Phase 2
40 H5N1 (Clade 2) Vaccination of Adults and Elderly Completed NCT00680069 Phase 1, Phase 2
41 H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses Completed NCT02921997 Phase 2 AS03
42 Immunogenicity and Safety Study of a Booster Vaccination With a Recombinant H5N1 Influenza HA Vaccine in Primed Adults Completed NCT01195038 Phase 2
43 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Monovalent Pandemic H5N1 Vaccine in Adults Completed NCT01416571 Phase 2
44 Inactivated Influenza A/H5N1 Vaccine in the Elderly Completed NCT00230750 Phase 1, Phase 2 Placebo
45 Immune Responses to H5N1 Vaccine With and Without AS03 Adjuvant Completed NCT01578317 Phase 1, Phase 2
46 A/H5N1 Vaccine in Healthy Children Aged 2-9 Years Completed NCT00133536 Phase 1, Phase 2 Placebo
47 Assess the Safety & Immunogenicity of Stored Inactivated Influenza H5N1 Virus Vaccine Given With & Without Stored MF59 Adjuvant Completed NCT02680002 Phase 2
48 H7N9 Mix and Match With MF59 in Healthy Adults Completed NCT01938742 Phase 2 MF59
49 Safety, Reactogenicity and Immunogenicity of an H5N1 VLP Completed NCT00519389 Phase 1, Phase 2
50 High-Dose Versus Standard-Dose Oseltamivir to Treat Severe Influenza and Avian Influenza Completed NCT00298233 Phase 2 Oseltamivir

Search NIH Clinical Center for Avian Influenza

Cochrane evidence based reviews: influenza in birds

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Genetic Tests for Avian Influenza

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Anatomical Context for Avian Influenza

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MalaCards organs/tissues related to Avian Influenza:

41
Testes, Eye, Lung, T Cells, B Cells, Monocytes, Bone
Sources

Publications for Avian Influenza

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Articles related to Avian Influenza:

(show top 50) (show all 1923)
# Title Authors Year
1
Stability of retroviral pseudotypes carrying the hemagglutinin of avian influenza viruses under various storage conditions. ( 30347199 )
2019
2
Development of a DAS-ELISA for detection of H9N2 avian influenza virus. ( 30355516 )
2019
3
Scoring Amino Acid Mutations to Predict Avian-to-Human Transmission of Avian Influenza Viruses. ( 29966263 )
2018
4
Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt. ( 29946159 )
2018
5
The PA-interacting host protein nucleolin acts as an antiviral factor during highly pathogenic H5N1 avian influenza virus infection. ( 29974255 )
2018
6
Human Infection with Avian Influenza A(H7N2) Virus - Virginia, 2002. ( 29430844 )
2018
7
Novel Highly Pathogenic Avian Influenza A(H5N6) Virus in the Netherlands, December 2017. ( 29381134 )
2018
8
Assessment of human-to-human transmissibility of avian influenza A(H7N9) virus across five waves by analyzing clusters of case-patients in mainland China, 2013-2017. ( 29961834 )
2018
9
Discrimination of Avian Influenza Virus Subtypes using Host-Cell Infection Fingerprinting by a Sulfinate-based Fluorescence Superoxide Probe. ( 29933516 )
2018
10
Spatio-temporal patterns of highly pathogenic avian influenza virus subtype H5N8 spread, France, 2016 to 2017. ( 29970219 )
2018
11
Erratum: Author Correction: Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus. ( 29799537 )
2018
12
Two reassortant types of highly pathogenic H5N8 avian influenza virus from wild birds in Central China in 2016. ( 29410395 )
2018
13
Global avian influenza outbreaks 2010-2016: a systematic review of their distribution, avian species and virus subtype. ( 29368637 )
2018
14
Viral interference between low pathogenic avian influenza H9N2 and avian infectious bronchitis viruses in vitro and in ovo. ( 29940196 )
2018
15
Cottontail rabbits shed clade 2.3.4.4 H5 highly pathogenic avian influenza A viruses. ( 29948379 )
2018
16
Electrostatic Variation of Haemagglutinin as a Hallmark of the Evolution of Avian Influenza Viruses. ( 29386534 )
2018
17
Prolonged evolution of virus-specific memory T cell immunity post severe avian influenza A (H7N9) virus infection. ( 29925664 )
2018
18
Unlocking pandemic potential: prevalence and spatial patterns of key substitutions in avian influenza H5N1 in Egyptian isolates. ( 29980172 )
2018
19
A rapid and transient innate immune response to avian influenza infection in mallards. ( 29407578 )
2018
20
Spatial transmission of H5N6 highly pathogenic avian influenza viruses among wild birds in Ibaraki Prefecture, Japan, 2016-2017. ( 29392495 )
2018
21
Identification of high risk areas for avian influenza outbreaks in California using disease distribution models. ( 29385158 )
2018
22
Avian Influenza Virus Surveillance in High Arctic Breeding Geese, Greenland. ( 29944408 )
2018
23
Sudden emergence of human infections with H7N9 avian influenza A virus in Hubei province, central China. ( 29410505 )
2018
24
Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools. ( 29970470 )
2018
25
Local amplification of highly pathogenic avian influenza H5N8 viruses in wild birds in the Netherlands, 2016 to 2017. ( 29382414 )
2018
26
Induction of immune response in chickens primed in ovo with an inactivated H9N2 avian influenza virus vaccine. ( 29970157 )
2018
27
Phylogenetic classification of hemagglutinin gene of H9N2 avian influenza viruses isolated in China during 2012-2016 and evaluation of selected candidate vaccine strains. ( 29931183 )
2018
28
Characterization of avian influenza H9N2 viruses isolated from ostriches (Struthio camelus). ( 29396439 )
2018
29
Convergent Evolution of Human-Isolated H7N9 Avian Influenza A Viruses. ( 29438519 )
2018
30
Avian influenza prevention zone extended. ( 29374112 )
2018
31
Genetic and biological characterization of H9N2 avian influenza viruses isolated in China from 2011 to 2014. ( 29969454 )
2018
32
Avian Influenza Virus Subtype H9N2 Affects Intestinal Microbiota, Barrier Structure Injury, and Inflammatory Intestinal Disease in the Chicken Ileum. ( 29783653 )
2018
33
Epidemiological and genetic characteristics of the fifth avian influenza A(H7N9) wave in Suzhou, China, from october 2016 to april 2017. ( 29404897 )
2018
34
Bactericidal and virucidal efficacies of potassium monopersulfate and its application for inactivating avian influenza virus on virus-spiked clothes. ( 29434116 )
2018
35
The Application of NHEJ-CRISPR/Cas9 and Cre-Lox System in the Generation of Bivalent Duck Enteritis Virus Vaccine against Avian Influenza Virus. ( 29438322 )
2018
36
Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration. ( 29310581 )
2018
37
Broad-spectrum neutralization of avian influenza viruses by sialylated human milk oligosaccharides: in vivo assessment of 3'-sialyllactose against H9N2 in chickens. ( 29416087 )
2018
38
Avian influenza virus ecology and evolution through a climatic lens. ( 29980049 )
2018
39
Avian influenza surveillance in domestic waterfowl and environment of live bird markets in Bangladesh, 2007-2012. ( 29925854 )
2018
40
Protecting poultry from avian influenza. ( 29419504 )
2018
41
Similar transmissibility of the Italian H7N1 highly pathogenic avian influenza virus and its low pathogenic avian influenza virus predecessor. ( 29428086 )
2018
42
Comparison of patients with avian influenza A (H7N9) and influenza A (H1N1) complicated by acute respiratory distress syndrome. ( 29561442 )
2018
43
Ventilator management for acute respiratory distress syndrome associated with avian influenza A (H7N9) virus infection: A case series. ( 29576824 )
2018
44
Molecular characterization of H10 subtype avian influenza viruses isolated from poultry in Eastern China. ( 30302582 )
2018
45
Pathology of clade 2.3.2.1 avian influenza virus (H5N1) infection in quails and ducks in Bangladesh. ( 30303027 )
2018
46
Identifying key bird species and geographical hotspots of avian influenza A (H7N9) virus in China. ( 30305184 )
2018
47
Aerosol exposure enhanced infection of low pathogenic avian influenza viruses in chickens. ( 30307712 )
2018
48
Dynamics of the 2004 avian influenza H5N1 outbreak in Thailand: The role of duck farming, sequential model fitting and control. ( 30314780 )
2018
49
Identification of avian influenza virus subtype H9N2 in chicken farms in Indonesia. ( 30314797 )
2018
50
A 113-amino-acid truncation at the NS1 C-terminus is a determinant for viral replication of H5N6 avian influenza virus in vitro and in vivo. ( 30322535 )
2018
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Variations for Avian Influenza

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Expression for Avian Influenza

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Search GEO for disease gene expression data for Avian Influenza.
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Pathways for Avian Influenza

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Pathways related to Avian Influenza according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
PAK Pathway 64
Show member pathways
 13.22 CCR1 CRK CXCL10 CXCL8 IL6 TNF
2
Cytokine Signaling in Immune system 66
Show member pathways
 13.17 CCR1 CRK CXCL10 CXCL8 DDX58 IL6
3
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.85 CXCL10 CXCL8 IL6 IRF7 SFTPD STAT2
4
Human cytomegalovirus infection 37
Show member pathways
 12.81 CCR1 CRK CXCL8 DDX58 IL6 IRF7
5
CCR5 Pathway in Macrophages 64
Show member pathways
 12.79 CCR1 CRK CXCL10 CXCL8 STAT2
6
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 66
Show member pathways
 12.64 CXCL10 CXCL8 DDX58 IL6 IRF7 TNF
7
NF-kappaB Signaling 4
12.45 CXCL10 DDX58 IRF7 STAT2 TNF
8
IL-17 Family Signaling Pathways 65
Show member pathways
 12.24 CXCL10 CXCL8 IL6 TNF
9
Toll Comparative Pathway 64
Show member pathways
 12.23 CRK CXCL8 IL6 TNF
10
Diseases associated with the TLR signaling cascade 66
Show member pathways
 12.16 CXCL8 IL6 IRF7 TNF
11
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.16 CXCL8 IL6 IRF7 STAT2 TNF
12
Bacterial infections in CF airways 22
Show member pathways
 12.05 CXCL10 CXCL8 IL6 SFTPD TNF
13
Influenza A 37
Show member pathways
 11.96 CXCL10 CXCL8 DDX58 FURIN IL6 IRF7
14
Epstein-Barr virus infection 37
11.94 CXCL10 DDX58 IL6 IRF7 STAT2 TNF
15
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 11.91 CCR1 CXCL10 CXCL8
16
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.91 CCR1 IL6 TNF
17
Interleukin-4 and 13 signaling 66
11.9 CXCL8 IL6 TNF
18
Spinal Cord Injury 1
11.9 CXCL10 CXCL8 IL6 TNF
19
TNF signaling pathway 37
11.88 CXCL10 IL6 TNF
20
Hepatitis C 37
11.88 CXCL8 DDX58 IRF7 STAT2 TNF
21
Senescence and Autophagy in Cancer 1
11.86 CXCL8 IL6 IRF7
22
AGE-RAGE signaling pathway in diabetic complications 37
11.82 CXCL8 IL6 TNF
23
Jak-Stat Signaling Pathway (sino) 67
11.8 CCR1 IL6 STAT2
24
Amoebiasis 37
11.8 CXCL8 IL6 TNF
25
NF-kappa B signaling pathway 37
11.8 CXCL8 DDX58 TNF
26
Rheumatoid arthritis 37
11.77 CXCL8 IL6 TNF
27
Pertussis 37
11.68 CXCL8 IL6 TNF
28
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.64 CXCL10 IL6 TNF
29
LPA receptor mediated events 1
11.6 CRK CXCL8 IL6
30
Lung fibrosis 1
11.57 CXCL8 IL6 TNF
31
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.57 CXCL8 IL6 TNF
32
Legionellosis 37
11.49 CXCL8 IL6 TNF
33
Malaria 37
11.42 CXCL8 IL6 TNF
34
G-protein signaling_RhoB regulation pathway 22
11.1 CXCL10 CXCL8 IL6 TNF
35
Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics 61
Show member pathways
 11.05 DDX58 IRF7 STAT2
36
Interleukin-10 signaling 66
11.04 CCR1 CXCL10 CXCL8 IL6 TNF
37
Overview of nanoparticle effects 1
10.93 CXCL8 IL6 TNF
38
NGF processing 66
Show member pathways
 10.13 FURIN PCSK5 PCSK6
Sources

GO Terms for Avian Influenza

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Cellular components related to Avian Influenza according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 CXCL10 CXCL8 FURIN IL6 PCSK5 PCSK6
2 extracellular space GO:0005615 9.23 CXCL10 CXCL8 FURIN IL6 PCSK5 PCSK6
3 Golgi lumen GO:0005796 9.13 FURIN PCSK5 PCSK6

Biological processes related to Avian Influenza according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CCR1 CXCL10 CXCL8 IL6 TNF
2 inflammatory response GO:0006954 9.85 CCR1 CXCL10 CXCL8 IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.78 CXCL10 CXCL8 IL6 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.77 DDX58 IL6 TNF
5 chemokine-mediated signaling pathway GO:0070098 9.71 CCR1 CXCL10 CXCL8
6 positive regulation of interleukin-6 production GO:0032755 9.7 DDX58 IL6 TNF
7 protein processing GO:0016485 9.67 FURIN PCSK5 PCSK6
8 response to virus GO:0009615 9.67 CXCL10 DDX58 IRF7 TNF
9 positive regulation of monocyte chemotaxis GO:0090026 9.61 CCR1 CXCL10
10 positive regulation of glial cell proliferation GO:0060252 9.61 IL6 TNF
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 FURIN TNF
12 positive regulation of interferon-alpha production GO:0032727 9.58 DDX58 IRF7
13 signal peptide processing GO:0006465 9.58 FURIN PCSK5
14 secretion by cell GO:0032940 9.57 FURIN PCSK6
15 negative regulation of lipid storage GO:0010888 9.56 IL6 TNF
16 defense response to virus GO:0051607 9.55 CXCL10 DDX58 IL6 IRF7 STAT2
17 positive regulation of neuroinflammatory response GO:0150078 9.51 IL6 TNF
18 peptide hormone processing GO:0016486 9.5 FURIN PCSK5 PCSK6
19 peptide biosynthetic process GO:0043043 9.43 FURIN PCSK5
20 embryonic digestive tract development GO:0048566 9.43 CXCL8 PCSK5 TNF
21 nerve growth factor production GO:0032902 9.4 FURIN PCSK6
22 cytokine-mediated signaling pathway GO:0019221 9.17 CCR1 CRK CXCL10 CXCL8 IL6 STAT2
23 regulation of lipoprotein lipase activity GO:0051004 9.13 FURIN PCSK5 PCSK6

Molecular functions related to Avian Influenza according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.62 FURIN PCSK5 PCSK6 TMPRSS13
2 cytokine activity GO:0005125 9.56 CXCL10 CXCL8 IL6 TNF
3 endopeptidase activity GO:0004175 9.54 FURIN PCSK5 PCSK6
4 protein binding GO:0005515 9.53 BCL2L10 CCR1 CRK CXCL10 CXCL8 DDX58
5 serine-type peptidase activity GO:0008236 9.26 FURIN PCSK5 PCSK6 TMPRSS13
6 nerve growth factor binding GO:0048406 9.16 FURIN PCSK6
Sources

Sources for Avian Influenza

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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