MCID: AVD001
MIFTS: 42

Avoidant Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Avoidant Personality Disorder

MalaCards integrated aliases for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 12 76 15 73
Anxious Personality Disorder 12 73
Personality Disorders 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1509
ICD10 33 F60.6
ICD9CM 35 301.82
MeSH 44 D010554
NCIt 50 C92636
SNOMED-CT 68 191771004 37746008

Summaries for Avoidant Personality Disorder

Disease Ontology : 12 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary : Avoidant Personality Disorder, also known as anxious personality disorder, is related to disease of mental health and personality disorder, and has symptoms including sleep disturbances, photophobia and personality changes. An important gene associated with Avoidant Personality Disorder is AMY1A (Amylase, Alpha 1A (Salivary)), and among its related pathways/superpathways are PAK Pathway and CCR5 Pathway in Macrophages. Affiliated tissues include brain, testes and amygdala, and related phenotypes are liver/biliary system and nervous system

Wikipedia : 76 Avoidant personality disorder (AvPD) is a Cluster C personality disorder. Those affected display a... more...

Related Diseases for Avoidant Personality Disorder

Diseases related to Avoidant Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 disease of mental health 28.1 CRH FMR1 MAOA WASF1 WASF2
2 personality disorder 10.7
3 whiplash 10.6 CCL5 CCR5
4 phobia, specific 10.6 FMR1 MAOA
5 atypical depressive disorder 10.5 CRH MAOA
6 social phobia 10.4
7 anxiety 10.3
8 narcissistic personality disorder 10.3 FLNA WASF2
9 immune deficiency disease 10.1 CCR5 CXCL12 CXCR4
10 aids dementia complex 10.1 CXCL12 CXCR4
11 human immunodeficiency virus infectious disease 10.0 CCL5 CCR5 CXCL12 CXCR4
12 viral infectious disease 10.0 CCL5 CCR5 CXCR4
13 whim syndrome 9.9 CXCL12 CXCR4
14 intraocular lymphoma 9.8 CXCL12 CXCR4 CXCR5
15 schizophrenia 9.8
16 bulimia nervosa 9.8
17 eating disorder 9.8
18 depression 9.8
19 human immunodeficiency virus type 1 9.7 CCL5 CCR5 CXCL12 CXCR4
20 obsessive-compulsive disorder 9.7
21 schizotypal personality disorder 9.7
22 borderline personality disorder 9.7
23 obsessive-compulsive personality disorder 9.7
24 intermittent explosive disorder 9.7
25 impotence 9.7
26 substance abuse 9.7
27 tobacco addiction 9.5 MAOA WASF1 WASF2
28 myocardial infarction 9.5 CCL5 CCR5 CXCL12 CXCR4 MME
29 lymphoma, non-hodgkin, familial 9.4 CXCL12 CXCR4 CXCR5 MME
30 mental depression 9.2 CRH MAOA WASF1 WASF2
31 dependent personality disorder 9.2 MAOA MME WASF1 WASF2

Comorbidity relations with Avoidant Personality Disorder via Phenotypic Disease Network (PDN):


Dependent Personality Disorder Dysthymic Disorder
Major Depressive Disorder

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to Avoidant Personality Disorder

Symptoms & Phenotypes for Avoidant Personality Disorder

UMLS symptoms related to Avoidant Personality Disorder:


sleep disturbances, photophobia, personality changes, restlessness, pseudobulbar behavioral symptoms

MGI Mouse Phenotypes related to Avoidant Personality Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.5 WASF1 WASF2 CCR5 CRH CXCL12 FLNA
2 nervous system MP:0003631 9.36 WASF2 CCR5 CRH CTSB CXCL12 CXCR4

Drugs & Therapeutics for Avoidant Personality Disorder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Group Based Schema Therapy in the Treatment of Personality Disorders Completed NCT00247234 Not Applicable
2 Changes in the Brain as Borderline Patients Learn to Regulate Their Emotions Completed NCT02465697 Not Applicable

Search NIH Clinical Center for Avoidant Personality Disorder

Cochrane evidence based reviews: personality disorders

Genetic Tests for Avoidant Personality Disorder

Anatomical Context for Avoidant Personality Disorder

MalaCards organs/tissues related to Avoidant Personality Disorder:

41
Brain, Testes, Amygdala

Publications for Avoidant Personality Disorder

Articles related to Avoidant Personality Disorder:

(show top 50) (show all 100)
# Title Authors Year
1
Relationships Among Avoidant Personality Disorder, Social Anxiety Disorder, and Normative Personality Traits: A Twin Study. ( 29505386 )
2018
2
Avoidant personality disorder: current insights. ( 29563846 )
2018
3
Avoidant personality disorder and social phobia: Does mindreading make the difference? ( 29096207 )
2018
4
The fear of being laughed at as additional diagnostic criterion in social anxiety disorder and avoidant personality disorder? ( 29176893 )
2017
5
Stability or instability in avoidant personality disorder:Mode fluctuations within schema therapy sessions. ( 28527713 )
2017
6
Examination of DSM-5 Section III avoidant personality disorder in a community sample. ( 28703479 )
2017
7
Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms. ( 27155069 )
2016
8
Avoidant personality disorder as a social anxiety phenotype: risk factors, associations and treatment. ( 26651009 )
2016
9
Avoidant Personality Disorder: a Current Review. ( 26830887 )
2016
10
Group schema therapy versus group cognitive behavioral therapy for social anxiety disorder with comorbid avoidant personality disorder: study protocol for a randomized controlled trial. ( 27717405 )
2016
11
A personality and impairment approach to examine the similarities and differences between avoidant personality disorder and social anxiety disorder. ( 27653504 )
2016
12
Mindreading Dysfunction in Avoidant Personality Disorder Compared With Other Personality Disorders. ( 27227557 )
2016
13
Affective Instability as a Clinical Feature of Avoidant Personality Disorder. ( 27505187 )
2016
14
Sex determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder. ( 27547506 )
2016
15
The Talking Cure of Avoidant Personality Disorder: Remission through Earned-Secure Attachment. ( 27662043 )
2016
16
Paroxetine, Cognitive Therapy or Their Combination in the Treatment of Social Anxiety Disorder with and without Avoidant Personality Disorder: A Randomized Clinical Trial. ( 27744447 )
2016
17
Metacognitive interpersonal therapy for co-occurrent avoidant personality disorder and substance abuse. ( 25557644 )
2015
18
Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder. ( 26481549 )
2015
19
Longitudinal Associations Between Social Anxiety Disorder and Avoidant Personality Disorder: A Twin Study. ( 26569037 )
2015
20
Correction: Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. ( 25978045 )
2015
21
Attachment styles in patients with avoidant personality disorder compared with social phobia. ( 26332087 )
2015
22
Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. ( 26129819 )
2015
23
Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. ( 25815817 )
2015
24
The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. ( 24275960 )
2014
25
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
26
Elevated amygdala activity during reappraisal anticipation predicts anxiety in avoidant personality disorder. ( 25451388 )
2014
27
Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder. ( 25215596 )
2014
28
Social Phobia and Avoidant Personality Disorder: Similar but Different? ( 23398095 )
2013
29
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. ( 24378158 )
2013
30
Personality functioning in patients with avoidant personality disorder and social phobia. ( 23786266 )
2013
31
A parallel process growth model of avoidant personality disorder symptoms and personality traits. ( 22506627 )
2013
32
Self-esteem and other-esteem in college students with borderline and avoidant personality disorder features: An experimental vignette study. ( 24343980 )
2013
33
Brief Cognitive Therapy for Avoidant Personality Disorder. ( 24377411 )
2013
34
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? ( 22705954 )
2012
35
Speed and accuracy of facial expression classification in avoidant personality disorder: a preliminary study. ( 22448805 )
2011
36
The effect of Avoidant Personality Disorder on the persistence of Generalized Social Anxiety Disorder in the general population: results from a longitudinal, nationally representative mental health survey. ( 21308885 )
2011
37
Psychotherapy of an older adult with an avoidant personality disorder. ( 20880430 )
2011
38
Changes in defensive functioning in a case of avoidant personality disorder. ( 22402007 )
2010
39
Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? ( 19536877 )
2010
40
Relations among symptoms of social phobia subtypes, avoidant personality disorder, panic, and depression. ( 20171323 )
2010
41
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. ( 20677852 )
2010
42
Avoidant personality disorder symptoms in first-degree relatives of schizophrenia patients predict performance on neurocognitive measures: the UCLA family study. ( 20053537 )
2010
43
Avoidant personality disorder and its relationship to social phobia. ( 19187715 )
2009
44
The relationship between generalized social phobia and avoidant personality disorder in a national mental health survey. ( 19031488 )
2009
45
Predictors of withdrawal: possible precursors of avoidant personality disorder. ( 19583885 )
2009
46
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. ( 19683617 )
2009
47
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? ( 19728570 )
2009
48
The impact of avoidant personality disorder on psychosocial impairment is substantial. ( 19333817 )
2009
49
A functionalist perspective on social anxiety and avoidant personality disorder. ( 19825257 )
2009
50
Psychoanalysis of avoidant personality disorder: a systematic case study of process and outcome. ( 19516064 )
2009

Variations for Avoidant Personality Disorder

Expression for Avoidant Personality Disorder

Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for Avoidant Personality Disorder

GO Terms for Avoidant Personality Disorder

Cellular components related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 AMY1A AMY1B AMY1C CTSB CXCL12 CXCR4
2 extracellular region GO:0005576 9.32 AMY1A AMY1B AMY1C C6orf15 CCL5 CRH
3 SCAR complex GO:0031209 8.96 WASF1 WASF2

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to virus GO:0009615 9.65 CCL5 CXCL12 CXCR4
2 Rac protein signal transduction GO:0016601 9.51 WASF1 WASF2
3 positive regulation of monocyte chemotaxis GO:0090026 9.49 CCL5 CXCL12
4 positive regulation of calcium ion import GO:0090280 9.46 CRH CXCL12
5 positive regulation of T cell migration GO:2000406 9.43 CCL5 CXCL12
6 fusion of virus membrane with host plasma membrane GO:0019064 9.4 CCR5 CXCR4
7 lamellipodium morphogenesis GO:0072673 9.37 WASF1 WASF2
8 chemotaxis GO:0006935 9.35 CCL5 CCR5 CXCL12 CXCR4 CXCR5
9 dendritic cell chemotaxis GO:0002407 9.33 CCL5 CCR5 CXCR4
10 negative regulation of macrophage apoptotic process GO:2000110 9.32 CCL5 CCR5
11 entry into host cell GO:0030260 9.26 CCR5 CXCR4
12 chemokine-mediated signaling pathway GO:0070098 9.02 CCL5 CCR5 CXCL12 CXCR4 CXCR5

Molecular functions related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.65 CCR5 CXCR4 FLNA WASF1 WASF2
2 hydrolase activity, acting on glycosyl bonds GO:0016798 9.61 AMY1A AMY1B AMY1C
3 chemokine receptor activity GO:0004950 9.46 CCR5 CXCR4
4 C-C chemokine binding GO:0019957 9.4 CCR5 CXCR4
5 chemokine receptor binding GO:0042379 9.37 CCL5 CXCL12
6 cation binding GO:0043169 9.33 AMY1A AMY1B AMY1C
7 C-X-C chemokine receptor activity GO:0016494 9.32 CXCR4 CXCR5
8 alpha-amylase activity (releasing maltohexaose) GO:0103025 9.13 AMY1A AMY1B AMY1C
9 alpha-amylase activity GO:0004556 8.8 AMY1A AMY1B AMY1C

Sources for Avoidant Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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