MCID: AVD001
MIFTS: 43

Avoidant Personality Disorder

Categories: Mental diseases

Aliases & Classifications for Avoidant Personality Disorder

MalaCards integrated aliases for Avoidant Personality Disorder:

Name: Avoidant Personality Disorder 12 76 15 73
Anxious Personality Disorder 12 73
Personality Disorders 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1509
ICD10 33 F60.6
ICD9CM 35 301.82
MeSH 44 D010554
NCIt 50 C92636
SNOMED-CT 68 37746008

Summaries for Avoidant Personality Disorder

Disease Ontology : 12 A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

MalaCards based summary : Avoidant Personality Disorder, also known as anxious personality disorder, is related to antisocial personality disorder and conduct disorder, and has symptoms including photophobia, restlessness and personality changes. An important gene associated with Avoidant Personality Disorder is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Amino Acid metabolism. The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes.

Wikipedia : 76 Avoidant personality disorder (AvPD) is a Cluster C personality disorder. Those affected display a... more...

Related Diseases for Avoidant Personality Disorder

Diseases related to Avoidant Personality Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 antisocial personality disorder 34.0 MAOA SLC6A4
2 conduct disorder 31.2 MAOA SLC6A4 TPH1
3 personality disorder 30.9 MAOA SLC6A4 TPH1
4 social phobia 30.8 MAOA SLC6A4
5 anxiety 30.2 MAOA SLC6A4 TPH1
6 dysthymic disorder 30.2 MAOA SLC6A4
7 bipolar disorder 30.2 MAOA SLC6A4 TPH1
8 agoraphobia 30.1 MAOA SLC6A4
9 attention deficit-hyperactivity disorder 30.1 MAOA SLC6A4 TPH1
10 major depressive disorder 30.1 MAOA SLC6A4 TPH1
11 mood disorder 30.0 MAOA SLC6A4 TPH1
12 substance dependence 30.0 MAOA SLC6A4
13 panic disorder 30.0 MAOA SLC6A4 TPH1
14 pathological gambling 30.0 MAOA SLC6A4
15 alcohol dependence 29.8 MAOA SLC6A4 TPH1
16 post-traumatic stress disorder 29.8 MAOA SLC6A4
17 mental depression 29.7 MAOA SLC6A4 TPH1
18 chronic fatigue syndrome 29.7 MAOA SLC6A4
19 atypical depressive disorder 29.6 MAOA SLC6A4
20 generalized anxiety disorder 29.6 MAOA SLC6A4 TPH1
21 borderline personality disorder 29.6 MAOA SLC6A4 TPH1
22 disease of mental health 29.6 MAOA SLC6A4
23 depression 29.6 MAOA SLC6A4 TPH1
24 postpartum depression 29.6 MAOA SLC6A4
25 schizophrenia 29.5 MAOA SLC6A4 TPH1
26 substance abuse 29.5 MAOA SLC6A4
27 kleptomania 29.5 MAOA SLC6A4
28 psychotic disorder 29.5 SLC6A4 TPH1
29 paranoid schizophrenia 29.4 MAOA SLC6A4
30 opiate dependence 29.4 SLC6A4 TPH1
31 endogenous depression 29.4 MAOA SLC6A4 TPH1
32 obsessive-compulsive disorder 29.3 MAOA SLC6A4 TPH1
33 oppositional defiant disorder 29.2 MAOA SLC6A4
34 tobacco addiction 29.2 MAOA SLC6A4 TPH1
35 migraine with or without aura 1 29.0 MAOA SLC6A4 TPH1
36 dependent personality disorder 12.6
37 histrionic personality disorder 12.6
38 paranoid personality disorder 12.6
39 schizoid personality disorder 12.6
40 narcissistic personality disorder 12.5
41 multiple personality disorder 12.5
42 cyclothymic disorder 11.4
43 dissociative seizures 10.9
44 impulse control disorder 10.7
45 dystonia 11, myoclonic 10.5
46 digeorge syndrome 10.5
47 ceroid lipofuscinosis, neuronal, 8 10.5
48 ceroid lipofuscinosis, neuronal, 7 10.5
49 gardner-diamond syndrome 10.5
50 bronchopulmonary dysplasia 10.3

Comorbidity relations with Avoidant Personality Disorder via Phenotypic Disease Network (PDN):


Dependent Personality Disorder Dysthymic Disorder
Major Depressive Disorder

Graphical network of the top 20 diseases related to Avoidant Personality Disorder:



Diseases related to Avoidant Personality Disorder

Symptoms & Phenotypes for Avoidant Personality Disorder

UMLS symptoms related to Avoidant Personality Disorder:


photophobia, restlessness, personality changes, pseudobulbar behavioral symptoms, sleep disturbances

Drugs & Therapeutics for Avoidant Personality Disorder

Drugs for Avoidant Personality Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
2 tannic acid Approved Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Group Based Schema Therapy in the Treatment of Personality Disorders Completed NCT00247234 Not Applicable
2 Changes in the Brain as Borderline Patients Learn to Regulate Their Emotions Completed NCT02465697 Not Applicable
3 FCT Study: Reducing the Need for Out-of-Home Placements Recruiting NCT03641664 Not Applicable

Search NIH Clinical Center for Avoidant Personality Disorder

Cochrane evidence based reviews: personality disorders

Genetic Tests for Avoidant Personality Disorder

Anatomical Context for Avoidant Personality Disorder

MalaCards organs/tissues related to Avoidant Personality Disorder:

41
Brain, Eye, Testes, Amygdala, Heart, Ovary, Temporal Lobe

Publications for Avoidant Personality Disorder

Articles related to Avoidant Personality Disorder:

(show top 50) (show all 99)
# Title Authors Year
1
Relationships Among Avoidant Personality Disorder, Social Anxiety Disorder, and Normative Personality Traits: A Twin Study. ( 29505386 )
2018
2
Avoidant personality disorder: current insights. ( 29563846 )
2018
3
Avoidant personality disorder and social phobia: Does mindreading make the difference? ( 29096207 )
2018
4
The fear of being laughed at as additional diagnostic criterion in social anxiety disorder and avoidant personality disorder? ( 29176893 )
2017
5
Examination of DSM-5 Section III avoidant personality disorder in a community sample. ( 28703479 )
2017
6
Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms. ( 27155069 )
2016
7
Avoidant personality disorder as a social anxiety phenotype: risk factors, associations and treatment. ( 26651009 )
2016
8
Avoidant Personality Disorder: a Current Review. ( 26830887 )
2016
9
Group schema therapy versus group cognitive behavioral therapy for social anxiety disorder with comorbid avoidant personality disorder: study protocol for a randomized controlled trial. ( 27717405 )
2016
10
A personality and impairment approach to examine the similarities and differences between avoidant personality disorder and social anxiety disorder. ( 27653504 )
2016
11
Mindreading Dysfunction in Avoidant Personality Disorder Compared With Other Personality Disorders. ( 27227557 )
2016
12
Affective Instability as a Clinical Feature of Avoidant Personality Disorder. ( 27505187 )
2016
13
Sex determines cortisol and alpha-amylase responses to acute physical and psychosocial stress in patients with avoidant personality disorder. ( 27547506 )
2016
14
The Talking Cure of Avoidant Personality Disorder: Remission through Earned-Secure Attachment. ( 27662043 )
2016
15
Paroxetine, Cognitive Therapy or Their Combination in the Treatment of Social Anxiety Disorder with and without Avoidant Personality Disorder: A Randomized Clinical Trial. ( 27744447 )
2016
16
Metacognitive interpersonal therapy for co-occurrent avoidant personality disorder and substance abuse. ( 25557644 )
2015
17
Serum concentrations of chemokines (CCL-5 and CXCL-12), chemokine receptors (CCR-5 and CXCR-4), and IL-6 in patients with posttraumatic stress disorder and avoidant personality disorder. ( 26481549 )
2015
18
Longitudinal Associations Between Social Anxiety Disorder and Avoidant Personality Disorder: A Twin Study. ( 26569037 )
2015
19
Correction: Avoidant Personality Disorder versus Social Phobia: The Significance of Childhood Neglect. ( 25978045 )
2015
20
Attachment styles in patients with avoidant personality disorder compared with social phobia. ( 26332087 )
2015
21
Social anxiety disorders in clinical practice: differentiating social phobia from avoidant personality disorder. ( 26129819 )
2015
22
Avoidant personality disorder versus social phobia: the significance of childhood neglect. ( 25815817 )
2015
23
The neural correlates of anomalous habituation to negative emotional pictures in borderline and avoidant personality disorder patients. ( 24275960 )
2014
24
Doing Psychiatry Right: A Case of Severe Avoidant Personality Disorder with Obsessive-compulsive Personality Disorder, Obsessive Compulsive Disorder, Intermittent Explosive Disorder and Sexual Paraphilias. ( 25035563 )
2014
25
Elevated amygdala activity during reappraisal anticipation predicts anxiety in avoidant personality disorder. ( 25451388 )
2014
26
Population-based, multi-generational family clustering study of social anxiety disorder and avoidant personality disorder. ( 25215596 )
2014
27
Social Phobia and Avoidant Personality Disorder: Similar but Different? ( 23398095 )
2013
28
Multimodal examination of emotion regulation difficulties as a function of co-occurring avoidant personality disorder among women with borderline personality disorder. ( 24378158 )
2013
29
Personality functioning in patients with avoidant personality disorder and social phobia. ( 23786266 )
2013
30
A parallel process growth model of avoidant personality disorder symptoms and personality traits. ( 22506627 )
2013
31
Self-esteem and other-esteem in college students with borderline and avoidant personality disorder features: An experimental vignette study. ( 24343980 )
2013
32
Brief Cognitive Therapy for Avoidant Personality Disorder. ( 24377411 )
2013
33
Avoidant personality disorder in individuals with generalized social anxiety disorder: what does it add? ( 22705954 )
2012
34
Speed and accuracy of facial expression classification in avoidant personality disorder: a preliminary study. ( 22448805 )
2011
35
The effect of Avoidant Personality Disorder on the persistence of Generalized Social Anxiety Disorder in the general population: results from a longitudinal, nationally representative mental health survey. ( 21308885 )
2011
36
Psychotherapy of an older adult with an avoidant personality disorder. ( 20880430 )
2011
37
Changes in defensive functioning in a case of avoidant personality disorder. ( 22402007 )
2010
38
Does avoidant personality disorder impact on the outcome of treatment for bulimia nervosa? ( 19536877 )
2010
39
Relations among symptoms of social phobia subtypes, avoidant personality disorder, panic, and depression. ( 20171323 )
2010
40
Co-occurrence of avoidant personality disorder and child sexual abuse predicts poor outcome in long-standing eating disorder. ( 20677852 )
2010
41
Avoidant personality disorder symptoms in first-degree relatives of schizophrenia patients predict performance on neurocognitive measures: the UCLA family study. ( 20053537 )
2010
42
Avoidant personality disorder and its relationship to social phobia. ( 19187715 )
2009
43
The relationship between generalized social phobia and avoidant personality disorder in a national mental health survey. ( 19031488 )
2009
44
Predictors of withdrawal: possible precursors of avoidant personality disorder. ( 19583885 )
2009
45
Factor structure and diagnostic efficiency of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria for avoidant personality disorder in Hispanic men and women with substance use disorders. ( 19683617 )
2009
46
Social phobia and avoidant personality disorder: are they separate diagnostic entities or do they reflect a spectrum of social anxiety? ( 19728570 )
2009
47
The impact of avoidant personality disorder on psychosocial impairment is substantial. ( 19333817 )
2009
48
A functionalist perspective on social anxiety and avoidant personality disorder. ( 19825257 )
2009
49
Psychoanalysis of avoidant personality disorder: a systematic case study of process and outcome. ( 19516064 )
2009
50
Generalized social phobia and avoidant personality disorder: meaningful distinction or useless duplication? ( 17161000 )
2008

Variations for Avoidant Personality Disorder

Expression for Avoidant Personality Disorder

Search GEO for disease gene expression data for Avoidant Personality Disorder.

Pathways for Avoidant Personality Disorder

GO Terms for Avoidant Personality Disorder

Biological processes related to Avoidant Personality Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 circadian rhythm GO:0007623 8.62 SLC6A4 TPH1

Sources for Avoidant Personality Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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