MCID: AZS001
MIFTS: 45

Azoospermia

Categories: Reproductive diseases

Aliases & Classifications for Azoospermia

MalaCards integrated aliases for Azoospermia:

Name: Azoospermia 12 36 29 54 6 44 15 17 70
Spermatogenic Failure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14227
KEGG 36 H00890
ICD9CM 34 606.0
MeSH 44 D053713
NCIt 50 C80076
SNOMED-CT 67 425558002
ICD10 32 N46.0
UMLS 70 C0004509

Summaries for Azoospermia

KEGG : 36 Azoospermia is a disorder in which there is a complete absence of sperm in the semen. It is classified as obstructive azoospermia caused by problems with sperm transport and nonobstructive azoospermia caused by failure of spermatogenesis. Y-linked gene USP9Y has been implicated in moderate oligoasthenoteratozoospermia and azoospermia. SYCP3 mutations lead to complete infertility due to meiotic arrest.

MalaCards based summary : Azoospermia, also known as spermatogenic failure, is related to spermatogenic failure 4 and y chromosome infertility. An important gene associated with Azoospermia is DAZL (Deleted In Azoospermia Like). The drugs Metformin and insulin have been mentioned in the context of this disorder. Affiliated tissues include testis, testes and bone marrow, and related phenotypes are endocrine/exocrine gland and reproductive system

Disease Ontology : 12 A male infertility disease characterized by the absence of any measurable level of sperm in semen.

Wikipedia : 73 Azoospermia is the medical condition of a man whose semen contains no sperm. It is associated with... more...

Related Diseases for Azoospermia

Diseases related to Azoospermia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 330)
# Related Disease Score Top Affiliating Genes
1 spermatogenic failure 4 32.6 SYCP3 AR
2 y chromosome infertility 32.2 USP9Y RBMY1A1 DDX3Y DAZ3 DAZ2 DAZ1
3 spermatogenic failure, x-linked, 1 32.2 SYCP3 SOHLH1 DAZL BOLL
4 spermatogenic failure, y-linked, 2 32.1 USP9Y SOHLH1 RBMY1A1 DDX3Y DAZ4 DAZ3
5 spermatogenic failure 50 32.0 TEX15 SYCP3 SOHLH1 DAZL BOLL
6 male infertility with azoospermia or oligozoospermia due to single gene mutation 31.5 TEX15 TEX14 SYCP3 SOHLH1 CFTR
7 oligospermia 31.2 DAZL DAZ4 CFTR BOLL AR
8 partial deletion of y 31.0 USP9Y RBMY1A1 DDX3Y DAZ4 DAZ3 DAZ2
9 cryptorchidism, unilateral or bilateral 30.8 SYCP3 SOHLH1 DAZL CFTR AZF1 AR
10 testicular cancer 30.6 TEX14 DAZL AZF1 AR
11 hypogonadism 30.6 SOHLH1 FSHB AR
12 infertility 30.5 USP9Y TEX15 TEX14 SYCP3 FSHB DDX3Y
13 male infertility 30.3 USP9Y TEX15 TEX14 SYCP3 RBMY1A1 FSHB
14 premature menopause 29.9 SYCP3 SOHLH1 FSHB DAZL AR
15 spermatogenic failure 10 11.7
16 spermatogenic failure 9 11.7
17 spermatogenic failure 24 11.7
18 spermatogenic failure 6 11.7
19 spermatogenic failure 5 11.7
20 spermatogenic failure 33 11.7
21 spermatogenic failure 34 11.7
22 spermatogenic failure 18 11.7
23 spermatogenic failure 16 11.6
24 spermatogenic failure 19 11.6
25 spermatogenic failure 26 11.6
26 spermatogenic failure 27 11.6
27 spermatogenic failure 36 11.6
28 spermatogenic failure 37 11.6
29 spermatogenic failure 38 11.6
30 spermatogenic failure 43 11.6
31 spermatogenic failure 7 11.6
32 spermatogenic failure 11 11.6
33 morbid obesity and spermatogenic failure 11.6
34 spermatogenic failure 20 11.6
35 spermatogenic failure 21 11.6
36 spermatogenic failure 31 11.6
37 spermatogenic failure 35 11.6
38 spermatogenic failure 39 11.6
39 spermatogenic failure 40 11.6
40 spermatogenic failure 41 11.6
41 spermatogenic failure 42 11.6
42 spermatogenic failure 44 11.6
43 spermatogenic failure 17 11.6
44 spermatogenic failure, x-linked, 3 11.6
45 spermatogenic failure 45 11.6
46 spermatogenic failure 46 11.6
47 spermatogenic failure 47 11.6
48 spermatogenic failure 49 11.6
49 spermatogenic failure 51 11.6
50 young syndrome 11.5

Comorbidity relations with Azoospermia via Phenotypic Disease Network (PDN):


Prostate Cancer

Graphical network of the top 20 diseases related to Azoospermia:



Diseases related to Azoospermia

Symptoms & Phenotypes for Azoospermia

MGI Mouse Phenotypes related to Azoospermia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 AR BOLL CFTR DAZ2 FKBP6 FSHB
2 reproductive system MP:0005389 9.36 AR BOLL CFTR DAZ2 DDX3Y FKBP6

Drugs & Therapeutics for Azoospermia

Drugs for Azoospermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 4091 14219
2 insulin Phase 4
3 Insulin, Globin Zinc Phase 4
4 Chorionic Gonadotropin Phase 4
5 Anticoagulants Phase 4
6 Chelating Agents Phase 4
7 Hypoglycemic Agents Phase 4
8 Calcium, Dietary Phase 4
9
Calcium Nutraceutical Phase 4 7440-70-2 271
10
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
11
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
12
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
13
Testosterone undecanoate Approved, Investigational Phase 2, Phase 3 5949-44-0
14
Testosterone enanthate Approved Phase 2, Phase 3 315-37-7 9416
15
Gabapentin Approved, Investigational Phase 3 60142-96-3 3446
16
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3 8001-79-4
17 Follicle Stimulating Hormone Phase 3
18 Estrogens Phase 3
19 Hormone Antagonists Phase 2, Phase 3
20 Hormones Phase 2, Phase 3
21 Estrogen Receptor Antagonists Phase 3
22 Estrogen Antagonists Phase 3
23 Antineoplastic Agents, Hormonal Phase 2, Phase 3
24 Aromatase Inhibitors Phase 3
25 Castor Phase 2, Phase 3
26 Gastrointestinal Agents Phase 2, Phase 3
27 Anabolic Agents Phase 2, Phase 3
28 Cathartics Phase 2, Phase 3
29 Testosterone 17 beta-cypionate Phase 2, Phase 3
30 Androgens Phase 2, Phase 3
31 Laxatives Phase 2, Phase 3
32 Narcotics Phase 3
33 Psychotropic Drugs Phase 3
34 Excitatory Amino Acid Antagonists Phase 3
35 Neurotransmitter Agents Phase 3
36 Anticonvulsants Phase 3
37 Analgesics Phase 3
38 Anti-Anxiety Agents Phase 3
39
Goserelin Approved Phase 2 65807-02-5 47725 5311128
40
Isotretinoin Approved Phase 2 4759-48-2 5282379 5538
41
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 444795 5538
42 Dermatologic Agents Phase 2
43 Keratolytic Agents Phase 2
44
Polyestradiol phosphate Approved 28014-46-2
45
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
46
Lidocaine Approved, Vet_approved 137-58-6 3676
47 Antibodies
48 Immunoglobulins
49 Estradiol 3-benzoate
50 Estradiol 17 beta-cypionate

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Metformin for the Treatment of Unexplained Oligozspermia and Azoospermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
2 Effectiveness and Safety of uFSH for Severe Oligospermia or Azoospermia:A Multi-center,Open,Randomized,Interventional,and Phase4 Trial in China Unknown status NCT02307994 Phase 4 75IU uFSH
3 Follicle-stimulating Hormone Treatment for Infertile Male Patients With Non-obstructive Azoospermia: a Multicenter Randomized Clinical Trial Unknown status NCT02275169 Phase 3 Urofollitropin
4 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
5 Androgen Treatment in Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
6 The Use of Gabapentin for Post-Operative Pain Control and Narcotic Reduction in Scrotal Surgery Recruiting NCT04230980 Phase 3 Gabapentin;Placebo
7 Interest of Clomiphene Citrate (CC) Associated With a Second Testicular Sperm Extraction (TESE) in Patients With Non-obstructive Azoospermia (NOA) After Failure of a First TESE, on the Quantity of Sperm Cells Available for Intracytoplasmic Sperm Injection (ICSI). Randomized Double Blind Trial Versus Placebo. Not yet recruiting NCT03615547 Phase 3 Clomifene Citrate
8 GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia: A Single-center Prospective Study in China Unknown status NCT02544191 Phase 2 GnRHa/ hCG/ hMG
9 Testicular Injection of Autologous Human Bone Marrow Derived Stem Cells for Treatment of Patients With Azoospermia Unknown status NCT02041910 Phase 1, Phase 2
10 A Pilot Trial of 13-cis Retinoic Acid (Isotretinoin) for the Treatment of Men With Azoospermia Completed NCT03323801 Phase 2 13-cis retinoic acid
11 Intra-Testicular Transplantation of Purified Autologous Clusters of Differentiation (CD) 34+,133+, and Mesenchymal Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility. Recruiting NCT02641769 Phase 1, Phase 2
12 Efficiency Evaluation of Adipose-Derived Adult Stromal Vascular Cells in Patients With Spermatogenesis Disorders. Enrolling by invitation NCT03762967 Phase 2 Standard therapy.
13 Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility Unknown status NCT02932865
14 Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia Unknown status NCT01178463
15 Outcome of ICSI Using Cryopreserved Testicular Sperm From Infertile Men With Varicocele-associated Azoospermia Unknown status NCT02306499
16 Use of Semen TEX101 to Improve Sperm Retrieval Rates for Men With Non-obstructive Azoospermia Unknown status NCT02851966
17 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799
18 Predictors for Successful Sperm Reterival by Testicular Sperm Extraxtion(TESE) in Patients With Non Obstructive Azospermia Unknown status NCT03146260
19 Prospective Controlled Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls Unknown status NCT00282477
20 The Effect of Low Electrical Current on Testicular Spermatocyte Count Unknown status NCT02617173
21 Genetic Studies Spermatogenic Failure Completed NCT00548977
22 Fertility Preservation in Cases of Spermatogenesis Failure : Prospective Study for Klinefelter Syndrome With Non-mosaic Karyotype (47, XXY, Homogeneous) Completed NCT01918280
23 Are Estradiol and Testosterone Levels in Seminal Plasma Predictive for Efficient Spermatogenesis in Men With Non- Obstructive Azoospermia Completed NCT02255396
24 HPV as a Possible Cause of Azoospermia Completed NCT02329275
25 Insulin Resistance : a New Diagnosis of the Pathogenesis of Idiopathic Oligozoospermia and Non Obstructive Azoospermia Completed NCT01509482
26 The Acceptance, Safety, and Efficacy of Needle-free Jet Anaesthetic Technique (MadaJet) Versus Needle Injection for Sperm Retrieval in Patients With Azoospermia Completed NCT03181243
27 Comparison of FDG PET-CT Estimated Testis Functional Value Between Patients Having Positive Testicular Sperm Cells Extraction and Patients With a Negative Extraction, in Men With Azoospermia Completed NCT02043444
28 Seminal TEX101 as a Predictor of Recovery of Spermatogenesis in Azoospermic Men With Palpable Varicocele Completed NCT04397887
29 Prospective Evaluation of Microdissection Testicular Sperm Extraction in Non-Obstructive Azoospermic Men and Their IVF-ICSI Related Outcomes at ART Treatment. Completed NCT00484081
30 Isolation, Culture and Characterization Stem Cells From Testis Biopsy Completed NCT01375062
31 The Effects of Intratesticular PRP Injection Completed NCT04237779
32 Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility Completed NCT02339272
33 Increased Testicular Cd2+ & Infertility With Varicocele ( a Varicose Vein in the Scrotum) Completed NCT00044369
34 Management of Azoospermic Patients With Kleinfelter Syndrome Patients With Mesenchymal Stem Cell Injection Completed NCT02414295 Mesenchymal stem cell injection
35 Rete Testis Needle Aspiration for Retrieval of Sperm in Men With Azoospermia Using Ultrasound Guidance Recruiting NCT02418832
36 Retrieval of Sperm From Men With Azoospermia Using Ultrasound-guided Rete Testis Aspiration Recruiting NCT03291522
37 Prospective Cohort Study for Azoospermia Patients in Clinical Reproductive Medicine Management System/Electronic Medical Record Cohort Database (CCRM/EMRCD) Recruiting NCT03991663
38 Outcome of ICSI Using Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men: a Randomized Controlled Trial Recruiting NCT04675164
39 The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed Oocytes Recruiting NCT03809026
40 Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical Track Recruiting NCT02773498
41 Implementation of a Round Spermatid Injection Protocol in a Clinical Infertility Practice Recruiting NCT04053309
42 Surgical Sperm Retrieval in Non-obstructive Azoospermic Men: Microdissection Testicular Sperm Extraction vs. Multiple Needle-pass Percutaneous Testicular Sperm Aspiration Active, not recruiting NCT03550716
43 Anti-mullerian Hormone,Testesterone,Esrtadiol,Testesterone/Esrtadiol Ratio as Predictive Values for TESA and TESE Outcome in Non Obstructive Azoospermia Not yet recruiting NCT04308486
44 Seminal Level of Clusterin in Infertile Men as a Predictor for Spermatogenesis Before Testicular Sperm Extraction Not yet recruiting NCT03857828
45 Detection of Microdeletions in the Azoospermia Factor (AZF) Regions on the Human Y Chromosome in Infertile Male Patients Suspended NCT03497728
46 PET-MRI for Functional Imaging of the Testis: A New Methodology for Evaluation of the Infertile Male Withdrawn NCT02669108
47 A Randomized, Double-blind, Placebo-controlled Trial of Clomiphene Citrate of Clomiphene Citrate in Hypoandrogenism and Azoospermia Withdrawn NCT02137265 Clomiphene;Placebo

Search NIH Clinical Center for Azoospermia

Cochrane evidence based reviews: azoospermia

Genetic Tests for Azoospermia

Genetic tests related to Azoospermia:

# Genetic test Affiliating Genes
1 Azoospermia 29

Anatomical Context for Azoospermia

MalaCards organs/tissues related to Azoospermia:

40
Testis, Testes, Bone Marrow, Pituitary, Bone, Skin, Prostate

Publications for Azoospermia

Articles related to Azoospermia:

(show top 50) (show all 6471)
# Title Authors PMID Year
1
A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule. 54 61
20335278 2010
2
Follicle-stimulating hormone receptor gene haplotypes and male infertility in estonian population and meta-analysis. 61 54
20170288 2010
3
Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis. 61 54
19795350 2009
4
Is intracytoplasmic sperm injection essential for the treatment of hypogonadotrophic hypogonadism? A comparison between idiopathic and secondary hypogonadotrophic hypogonadism. 61 54
19824804 2009
5
Mutations in the protamine locus: association with spermatogenic failure? 54 61
19602509 2009
6
[Androgen receptor CAG gene polymorphism in men with azoospermia and oligozoospermia in Ukraine]. 54 61
20458976 2009
7
Cystic fibrosis transmembrane conductance regulator mutations in azoospermic and oligospermic men and their partners. 54 61
20021716 2009
8
Screening for Y-chromosome microdeletions in a population of infertile males in the Gaza Strip. 54 61
20485582 2009
9
[Importance should be attached to the causes of azoospermia]. 61 54
19852264 2009
10
Infertility and bilateral adrenal tumors. 61 54
19100538 2009
11
Molecular characterization and SNPs analysis of the porcine Deleted in AZoospermia Like (pDAZL) gene. 54 61
18620821 2009
12
The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population. 61 54
19088127 2009
13
Novel cause of hereditary obstructive azoospermia: a T2 allele in the CFTR gene. 61 54
19298730 2009
14
DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins. 61 54
19285026 2009
15
Spermatogenesis in a man with complete deletion of USP9Y. 61 54
19246359 2009
16
Single nucleotide polymorphism analysis of the follicle-stimulating hormone (FSH) receptor in Japanese with male infertility: identification of codon combination with heterozygous variations of the two discrete FSH receptor gene. 54 61
19550076 2009
17
Unique signatures of natural background radiation on human Y chromosomes from Kerala, India. 61 54
19242544 2009
18
Quantitative fluorescent-PCR detection of sex chromosome aneuploidies and AZF deletions/duplications. 54 61
19072570 2008
19
[AZF microdeletions are not related with recurrent spontaneous abortion]. 54 61
19157230 2008
20
The prevalence of azoospermia factor microdeletion on the Y chromosome of Chinese infertile men detected by multi-analyte suspension array technology. 54 61
18958351 2008
21
Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect. 54 61
18958354 2008
22
[Genetic causes of male infertility]. 61 54
19004117 2008
23
Sons conceived by assisted reproduction techniques inherit deletions in the azoospermia factor (AZF) region of the Y chromosome and the DAZ gene copy number. 54 61
18440997 2008
24
Molecular analysis of mutations and polymorphisms in the CFTR gene in male infertility. 54 61
18616886 2008
25
Assisted reproductive technology may increase clinical mutation detection in male offspring. 61 54
18258231 2008
26
[Detection of Y chromosome microdeletions in semen of patients with azoospermia: study of 241 cases]. 61 54
19024532 2008
27
Genomic analysis of Drosophila neuronal remodeling: a role for the RNA-binding protein Boule as a negative regulator of axon pruning. 61 54
18550751 2008
28
Do we need to search for gr/gr deletions in infertile men in a clinical setting? 61 54
18326516 2008
29
Expression of androgen receptor co-regulators in the testes of men with azoospermia. 61 54
17919607 2008
30
Identification of new breakpoints in AZFb and AZFc. 54 61
18326547 2008
31
[Molecular cytogenetic studies of 25 males with azoospermia]. 54 61
18393244 2008
32
Serum inhibin-B and follicle stimulating hormone as predictors of the presence of sperm in testicular fine needle aspirate in men with azoospermia. 61 54
18477551 2008
33
Seminal plasma lipocalin-type prostaglandin D synthase: a potential new marker for the diagnosis of obstructive azoospermia. 61 54
18206953 2008
34
Evolution of the DAZ gene and the AZFc region on primate Y chromosomes. 54 61
18366765 2008
35
Screening for Y-chromosome microdeletions in infertile Indian males: utility of simplified multiplex PCR. 61 54
18403789 2008
36
[Y chromosome and male infertility: what is a normal Y chromosome?]. 54 61
18547511 2008
37
CFTR mutations in the Algerian population. 61 54
17572159 2008
38
[Clinical, molecular and cytogenetic studies on 4 patients with 46, XX (SRY positive) male syndrome]. 61 54
18284058 2007
39
[Clinical significance and relevant laboratory techniques of detecting azoospermia factors of the Y chromosome]. 54 61
18284064 2007
40
Cytogenetic and molecular characterization of the derivative Y chromosome: a case study of an azoospermic patient. 54 61
17935509 2007
41
Routine screening for classical azoospermia factor deletions of the Y chromosome in azoospermic patients with Klinefelter syndrome. 54 61
17968468 2007
42
[Screening for the microdeletions of azoospermia factor on the Y chromosome in male infertile patients from Guangzhou]. 54 61
17922428 2007
43
Tag STS in the AZF region associated with azoospermia in a Tunisian population. 54 61
17409464 2007
44
Y chromosome haplogroups and susceptibility to testicular cancer. 54 61
17682003 2007
45
Transition protein 1 mRNA expression is not related to pregnancy rate in azoospermic men undergoing TESE-ICSI. 54 61
17683460 2007
46
[The analysis of CFTR mutations in men with azoospermia, oligozoospermia and asthenozoospermia]. 54 61
18050608 2007
47
Immunohistochemical analysis of connexin43 expression in infertile human testes. 61 54
17653298 2007
48
Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl. 61 54
17526644 2007
49
Elevated end-of-treatment serum INSL3 is associated with failure to completely suppress spermatogenesis in men receiving male hormonal contraception. 54 61
17314233 2007
50
Molecular analysis of Y chromosome microdeletions in idiopathic cases of male infertility in Serbia. 54 61
17853812 2007

Variations for Azoospermia

Copy number variations for Azoospermia from CNVD:

7 (show all 14)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 218759 7 116907252 117095954 Genomic rearrangement CFTR Azoospermia
2 266752 Y 1 57772954 Microdeletion Azoospermia
3 266760 Y 1 57772954 Microdeletions Azoospermia
4 266846 Y 11300000 57772954 Microdeletio Azoospermia
5 266849 Y 11300000 57772954 Microdeletion Azoospermia
6 266862 Y 11300000 57772954 Microdeletion DAZ1 Azoospermia
7 266963 Y 174481503 174538309 Microdeletion AZF1 Azoospermia
8 266968 Y 174481503 174538309 Microdeletion AZF1 Azoospermia
9 266969 Y 174481503 174538309 Microdeletion AZF1 Azoospermia
10 267104 Y 23539797 25607639 Deletion BPY2 Azoospermia
11 267118 Y 23684889 23754627 Deletion DAZ1 Azoospermia
12 267153 Y 24600763 26180436 Deletion CDY1 Azoospermia
13 267157 Y 24738968 26042240 Deletion CSPG4P1Y Azoospermia
14 267158 Y 24765501 26015710 Deletion GOLGA2P2Y Azoospermia

Expression for Azoospermia

Search GEO for disease gene expression data for Azoospermia.

Pathways for Azoospermia

GO Terms for Azoospermia

Cellular components related to Azoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.03 USP9Y TEX15 SYCP3 SOHLH1 RBMY1A1 FKBP6
2 cytoplasm GO:0005737 9.86 USP9Y TEX15 TEX14 SOHLH1 FSHB FKBP6
3 synaptonemal complex GO:0000795 9.26 SYCP3 FKBP6
4 protein-containing complex GO:0032991 9.23 DAZL DAZAP1 DAZ4 DAZ3 DAZ2 DAZ1

Biological processes related to Azoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10 TEX15 SOHLH1 FKBP6 DDX3Y DAZL DAZAP1
2 multicellular organism development GO:0007275 9.92 SOHLH1 DAZL DAZAP1 DAZ4 DAZ3 DAZ2
3 meiotic cell cycle GO:0051321 9.67 TEX15 SYCP3 FKBP6 BOLL
4 positive regulation of translational initiation GO:0045948 9.63 DAZL DAZ4 DAZ3 DAZ2 DAZ1 BOLL
5 3'-UTR-mediated mRNA stabilization GO:0070935 9.43 DAZL DAZ4 DAZ3 DAZ2 DAZ1 BOLL
6 male meiotic nuclear division GO:0007140 9.4 TEX15 TEX14
7 spermatogenesis GO:0007283 9.4 USP9Y TEX15 SOHLH1 FKBP6 DAZL DAZAP1

Molecular functions related to Azoospermia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.97 RBMY1A1 DDX3Y DAZL DAZAP1 DAZ4 DAZ3
2 nucleic acid binding GO:0003676 9.91 RBMY1A1 DDX3Y DAZL DAZAP1 DAZ4 DAZ3
3 mRNA 3'-UTR binding GO:0003730 9.7 DAZL DAZAP1 DAZ4 DAZ3 DAZ2 DAZ1
4 mRNA binding GO:0003729 9.56 RBMY1A1 DAZL DAZAP1 DAZ4 DAZ3 DAZ2
5 translation activator activity GO:0008494 9.1 DAZL DAZ4 DAZ3 DAZ2 DAZ1 BOLL

Sources for Azoospermia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....