MCID: BCL013
MIFTS: 34

B-Cell Adult Acute Lymphocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for B-Cell Adult Acute Lymphocytic Leukemia

MalaCards integrated aliases for B-Cell Adult Acute Lymphocytic Leukemia:

Name: B-Cell Adult Acute Lymphocytic Leukemia 12 15
Adult B-Cell Acute Lymphoblastic Leukemia 12
B-Cell Adult Acute Lymphoblastic Leukemia 73
Adult B Acute Lymphoblastic Leukemia 12
Adult B-Cell Lymphocytic Leukemia 12
Adult B-Lymphoblastic Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060592
NCIt 50 C9143
UMLS 73 C0279593

Summaries for B-Cell Adult Acute Lymphocytic Leukemia

MalaCards based summary : B-Cell Adult Acute Lymphocytic Leukemia, also known as adult b-cell acute lymphoblastic leukemia, is related to leukemia, acute lymphoblastic and acute lymphocytic leukemia, and has symptoms including bone pain An important gene associated with B-Cell Adult Acute Lymphocytic Leukemia is IKZF1 (IKAROS Family Zinc Finger 1), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs Cytarabine and Cortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include b cells, b lymphoblasts and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for B-Cell Adult Acute Lymphocytic Leukemia

Diseases in the B-Cell Adult Acute Lymphocytic Leukemia family:

T-Cell Adult Acute Lymphocytic Leukemia

Diseases related to B-Cell Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 30.2 ABL1 PAX5
2 acute lymphocytic leukemia 10.4
3 lymphocytic leukemia 10.2
4 leukemia 10.1
5 myelodysplastic syndrome 10.1
6 hematopoietic stem cell transplantation 10.1
7 neutropenia 10.1
8 precursor t-cell acute lymphoblastic leukemia 9.9 ABL1 IKZF1
9 hematologic cancer 9.8 ABL1 IKZF1 PAX5
10 childhood leukemia 9.8 ABL1 PBX1
11 leukemia, acute lymphoblastic 3 9.5 ABL1 IKZF1 PAX5 PBX1

Graphical network of the top 20 diseases related to B-Cell Adult Acute Lymphocytic Leukemia:



Diseases related to B-Cell Adult Acute Lymphocytic Leukemia

Symptoms & Phenotypes for B-Cell Adult Acute Lymphocytic Leukemia

UMLS symptoms related to B-Cell Adult Acute Lymphocytic Leukemia:


bone pain

MGI Mouse Phenotypes related to B-Cell Adult Acute Lymphocytic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
2 immune system MP:0005387 9.63 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
3 mortality/aging MP:0010768 9.43 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
4 neoplasm MP:0002006 8.92 IKZF1 IKZF3 MSI2 PAX5

Drugs & Therapeutics for B-Cell Adult Acute Lymphocytic Leukemia

Drugs for B-Cell Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 121)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Investigational Phase 2, Phase 3,Phase 1 147-94-4 6253
2
Cortisone acetate Approved, Investigational Phase 2, Phase 3 1950-04-4, 50-04-4 5745
3
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
5
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
6
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
7
Vincristine Approved, Investigational Phase 2, Phase 3 57-22-7, 2068-78-2 5978
8
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1 6055-19-2, 50-18-0 2907
9
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
10
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
11
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
12
Methotrexate Approved Phase 2, Phase 3 59-05-2, 1959-05-2 126941
13
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
14
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
15
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
16
Pegaspargase Approved, Investigational Phase 2, Phase 3 130167-69-0
17
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
18
leucovorin Approved Phase 2, Phase 3,Phase 3 58-05-9 6006 143
19
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
20
Dasatinib Approved, Investigational Phase 2, Phase 3,Phase 1 302962-49-8 3062316
21
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
22
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
23
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
24
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
25
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
26
Cortisone Experimental Phase 2, Phase 3 53-06-5 222786
27 Immunologic Factors Phase 2, Phase 3,Phase 1
28 Antiviral Agents Phase 2, Phase 3,Phase 1
29 Immunosuppressive Agents Phase 2, Phase 3,Phase 1
30 Anti-Infective Agents Phase 2, Phase 3,Phase 1
31 Antimetabolites Phase 2, Phase 3,Phase 1
32 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 1
33 Bone Density Conservation Agents Phase 2, Phase 3
34 Antineoplastic Agents, Hormonal Phase 2, Phase 3
35 Hormones Phase 2, Phase 3
36 Aspartic Acid Phase 2, Phase 3
37
asparaginase Phase 2, Phase 3
38 Autonomic Agents Phase 2, Phase 3
39
Isophosphamide mustard Phase 2, Phase 3 0
40 Keratolytic Agents Phase 2, Phase 3
41 Adjuvants, Immunologic Phase 2, Phase 3
42 Vitamins Phase 2, Phase 3
43 Anti-Inflammatory Agents Phase 2, Phase 3
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
45 Hydrocortisone-17-butyrate Phase 2, Phase 3
46 Anti-Bacterial Agents Phase 2, Phase 3
47 Folic Acid Antagonists Phase 2, Phase 3
48 Prednisolone acetate Phase 2, Phase 3
49 Calcium, Dietary Phase 2, Phase 3
50 Vitamin B9 Phase 2, Phase 3

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
2 Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors Completed NCT01326702 Phase 1, Phase 2 Bendamustine Hydrochloride;Veliparib
3 Ibrutinib and Blinatumomab in Treating Patients With Relapsed or Refractory B Acute Lymphoblastic Leukemia Recruiting NCT02997761 Phase 2 Ibrutinib
4 Pembrolizumab in Treating Minimal Residual Disease in Patients With Acute Lymphoblastic Leukemia Recruiting NCT02767934 Phase 2
5 Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Active, not recruiting NCT01256398 Phase 2 Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide Phosphate;Fludarabine Phosphate;Leucovorin Calcium;Melphalan;Mercaptopurine;Methotrexate;Tacrolimus;Vincristine Sulfate
6 Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia Active, not recruiting NCT00792948 Phase 2 Cyclophosphamide;Cytarabine;Dasatinib;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Leucovorin Calcium;Methotrexate;Methylprednisolone;Prednisone;Sirolimus;Tacrolimus;Vincristine Sulfate
7 Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Dasatinib, or Nilotinib Active, not recruiting NCT00036738 Phase 2 Cyclosporine;Dasatinib;Fludarabine Phosphate;Imatinib Mesylate;Mycophenolate Mofetil;Nilotinib
8 Ibrutinib in Treating Patients With Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia Terminated NCT02129062 Phase 2 Ibrutinib
9 Immunotoxin Therapy and Cytarabine in Treating Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Unknown status NCT01408160 Phase 1 Cytarabine
10 Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma Completed NCT01567709 Phase 1 Alisertib;Vorinostat
11 Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery Completed NCT00608361 Phase 1 Dasatinib
12 huJCAR014 CAR-T Cells in Treating Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia Recruiting NCT03103971 Phase 1 Cyclophosphamide;Fludarabine
13 Veliparib and Temozolomide in Treating Patients With Acute Leukemia Active, not recruiting NCT01139970 Phase 1 Temozolomide;Veliparib
14 Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection Terminated NCT02109224 Phase 1 Ibrutinib

Search NIH Clinical Center for B-Cell Adult Acute Lymphocytic Leukemia

Genetic Tests for B-Cell Adult Acute Lymphocytic Leukemia

Anatomical Context for B-Cell Adult Acute Lymphocytic Leukemia

MalaCards organs/tissues related to B-Cell Adult Acute Lymphocytic Leukemia:

41
B Cells, B Lymphoblasts, Bone, T Cells, Myeloid

Publications for B-Cell Adult Acute Lymphocytic Leukemia

Articles related to B-Cell Adult Acute Lymphocytic Leukemia:

(show all 17)
# Title Authors Year
1
Incorporating Immunotherapy Into the Treatment Strategies of B-Cell Adult Acute Lymphoblastic Leukemia: The Role of Blinatumomab and Inotuzumab Ozogamicin. ( 30231308 )
2018
2
Prognostic Effect of CD20 Expression in Adult B-cell Acute Lymphoblastic Leukemia. ( 29544762 )
2018
3
Prognostic significance of leukopenia during the induction phase in adult B cell acute lymphoblastic leukemia. ( 29628775 )
2018
4
Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia. ( 29423088 )
2018
5
Role of flow-cytometric immunophenotyping in prediction of BCR/ABL1 gene rearrangement in adult B-cell acute lymphoblastic leukemia. ( 29220871 )
2018
6
Prognostic significance of IKZF1 deletion in adult B cell acute lymphoblastic leukemia: a meta-analysis. ( 27815723 )
2017
7
Next-Generation Sequencing in Adult B Cell Acute Lymphoblastic Leukemia Patients. ( 28062215 )
2017
8
Integrated analysis of microRNA and transcription factor reveals important regulators and regulatory motifs in adult B-cell acute lymphoblastic leukemia. ( 28101583 )
2017
9
Adult B-Cell Acute Lymphoblastic Leukemia Dominated by Osteolytic Bone Involvement on CT But Less Impressive PET on FDG PET/CT Images. ( 28368891 )
2017
10
A novel IGH@ gene rearrangement associated with CDKN2A/B deletion in young adult B-cell acute lymphoblastic leukemia. ( 26998132 )
2016
11
Overexpression of MALT1-A20-NF-κB in adult B-cell acute lymphoblastic leukemia. ( 26213496 )
2015
12
Ikaros6 is associated with BCR-ABL1 and myeloid-associated antigens but indicates poor prognosis independently in Chinese adult B-cell acute lymphoblastic leukemia. ( 26309501 )
2015
13
ADAM28 overexpression regulated via the PI3K/Akt pathway is associated with relapse in de novo adult B-cell acute lymphoblastic leukemia. ( 26340916 )
2015
14
Preclinical and clinical evaluation of forodesine in pediatric and adult B-cell acute lymphoblastic leukemia. ( 23773454 )
2013
15
Urachal remnant infection leading to Pseudomonas aeruginosa bacteremia in induction therapy for adult B-cell acute lymphoblastic leukemia. ( 21858444 )
2011
16
Adult B-cell acute lymphoblastic leukemia with two unrelated abnormal cytogenetic clones. ( 20633764 )
2010
17
Improved outcome in adult B-cell acute lymphoblastic leukemia. ( 8555471 )
1996

Variations for B-Cell Adult Acute Lymphocytic Leukemia

Expression for B-Cell Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for B-Cell Adult Acute Lymphocytic Leukemia.

Pathways for B-Cell Adult Acute Lymphocytic Leukemia

Pathways related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 IKZF1 IKZF3 PAX5 PBX1

GO Terms for B-Cell Adult Acute Lymphocytic Leukemia

Cellular components related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.02 ABL1 IKZF1 IKZF3 PAX5 PBX1

Biological processes related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.56 IKZF1 IKZF3 PAX5 PBX1
2 transcription by RNA polymerase II GO:0006366 9.54 IKZF3 PAX5 PBX1
3 animal organ morphogenesis GO:0009887 9.32 PAX5 PBX1
4 thymus development GO:0048538 9.16 ABL1 PBX1
5 mesoderm development GO:0007498 8.96 IKZF1 IKZF3
6 spleen development GO:0048536 8.62 ABL1 PBX1

Molecular functions related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.46 IKZF1 IKZF3 PAX5 PBX1
2 DNA binding GO:0003677 9.35 ABL1 IKZF1 IKZF3 PAX5 PBX1
3 DNA-binding transcription factor activity GO:0003700 8.92 IKZF1 IKZF3 PAX5 PBX1

Sources for B-Cell Adult Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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