Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: BCL013
MIFTS: 34

B-Cell Adult Acute Lymphocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for B-Cell Adult Acute Lymphocytic Leukemia

About this section

MalaCards integrated aliases for B-Cell Adult Acute Lymphocytic Leukemia:

Name: B-Cell Adult Acute Lymphocytic Leukemia 12 15
Adult B Acute Lymphoblastic Leukemia 12 17
Adult B-Cell Acute Lymphoblastic Leukemia 12
B-Cell Adult Acute Lymphoblastic Leukemia 72
Adult B-Cell Lymphocytic Leukemia 12
Adult B-Lymphoblastic Leukemia 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060592
NCIt 50 C9143
UMLS 72 C0279593
Sources

Summaries for B-Cell Adult Acute Lymphocytic Leukemia

About this section
MalaCards based summary : B-Cell Adult Acute Lymphocytic Leukemia, also known as adult b acute lymphoblastic leukemia, is related to leukemia, acute lymphoblastic and precursor t-cell acute lymphoblastic leukemia, and has symptoms including bone pain An important gene associated with B-Cell Adult Acute Lymphocytic Leukemia is IKZF1 (IKAROS Family Zinc Finger 1), and among its related pathways/superpathways are NF-kappaB Signaling and B Cell Development Pathways. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include b cells, b lymphoblasts and t cells, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Sources

Related Diseases for B-Cell Adult Acute Lymphocytic Leukemia

About this section

Diseases in the B-Cell Adult Acute Lymphocytic Leukemia family:

T-Cell Adult Acute Lymphocytic Leukemia

Diseases related to B-Cell Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 30.1 PAX5 ABL1
2 precursor t-cell acute lymphoblastic leukemia 29.7 IKZF1 ABL1
3 leukemia, acute lymphoblastic 3 28.6 PBX1 PAX5 IKZF1 ABL1
4 lymphocytic leukemia 10.4
5 hematopoietic stem cell transplantation 10.3
6 leukemia, chronic lymphocytic 10.1
7 myeloma, multiple 10.1
8 myelodysplastic syndrome 10.1
9 graft-versus-host disease 10.1
10 mucositis 10.1
11 neutropenia 10.1
12 acute leukemia 10.1
13 acute t cell leukemia 10.1
14 lymphopenia 10.1
15 47,xyy 10.1
16 acute graft versus host disease 10.1
17 chromosomal triplication 10.1
18 leukemia, b-cell, chronic 10.1
19 splenomegaly 10.1
20 leukemia, acute myeloid 10.0
21 leukemia 10.0
22 precursor b lymphoblastic lymphoma/leukemia 10.0
23 posttransplant acute limbic encephalitis 10.0
24 childhood leukemia 9.7 PBX1 ABL1
25 hematologic cancer 9.3 PAX5 IKZF1 ABL1

Graphical network of the top 20 diseases related to B-Cell Adult Acute Lymphocytic Leukemia:



Diseases related to B-Cell Adult Acute Lymphocytic Leukemia
Sources

Symptoms & Phenotypes for B-Cell Adult Acute Lymphocytic Leukemia

About this section

UMLS symptoms related to B-Cell Adult Acute Lymphocytic Leukemia:


bone pain

MGI Mouse Phenotypes related to B-Cell Adult Acute Lymphocytic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 ABL1 IKZF1 IKZF3 IL21R MSI2 PAX5
2 endocrine/exocrine gland MP:0005379 9.72 ABL1 IKZF1 IL21R MSI2 PBX1
3 immune system MP:0005387 9.7 ABL1 IKZF1 IKZF3 IL21R MSI2 PAX5
4 mortality/aging MP:0010768 9.5 ABL1 IKZF1 IKZF3 IL21R MSI2 PAX5
5 neoplasm MP:0002006 8.92 IKZF1 IKZF3 MSI2 PAX5
Sources

Drugs & Therapeutics for B-Cell Adult Acute Lymphocytic Leukemia

About this section

Drugs for B-Cell Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
3
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
4
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
7
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
8
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
9
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
10
Ifosfamide Approved Phase 3 3778-73-2 3690
11
Thioguanine Approved Phase 3 154-42-7 2723601
12
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
13
Sargramostim Approved, Investigational Phase 3 83869-56-1, 123774-72-1
14
Lenograstim Approved, Investigational Phase 3 135968-09-1
15
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
16
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
17
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
18
Carmustine Approved, Investigational Phase 3 154-93-8 2578
19
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
20
Ichthammol Approved Phase 2, Phase 3 8029-68-3
21
Dasatinib Approved, Investigational Phase 2, Phase 3 302962-49-8 3062316
22
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
23
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
24
Mercaptopurine Approved Phase 3 50-44-2 667490
25
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
26
leucovorin Approved Phase 3 58-05-9 143 6006
27
Etoposide Approved Phase 3 33419-42-0 36462
28
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
29
Daunorubicin Approved Phase 3 20830-81-3 30323
30
Cytarabine Approved, Experimental, Investigational Phase 3 147-94-4, 65-46-3 6253
31
rituximab Approved Phase 3 174722-31-7 10201696
32
Pegaspargase Approved, Investigational Phase 3 130167-69-0
33
Melphalan Approved Phase 3 148-82-3 460612 4053
34
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
35
Aspartic acid Approved, Nutraceutical Phase 2, Phase 3 56-84-8 5960
36
Tyrosine Approved, Investigational, Nutraceutical Phase 2, Phase 3 60-18-4 6057
37
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
38
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
39
Emodepside Investigational, Vet_approved Phase 2, Phase 3 155030-63-0
40
Cortisone Experimental Phase 2, Phase 3 53-06-5 222786
41 Anti-Inflammatory Agents Phase 3
42 Gastrointestinal Agents Phase 3
43 Antiemetics Phase 3
44 HIV Protease Inhibitors Phase 3
45 glucocorticoids Phase 3
46
protease inhibitors Phase 3
47 Hormones Phase 3
48 Antineoplastic Agents, Hormonal Phase 3
49 Hormone Antagonists Phase 3
50 Autonomic Agents Phase 3

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 A Pilot Study of Dose Intensification of Methotrexate in Patients With Advanced-Stage (III/IV) Small Non-Cleaved Cell Non-Hodgkins Lymphoma and B-Cell All Completed NCT00005977 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;vincristine sulfate
2 A Phase III Trial Comparing ARA-C/High-Dose Mitoxantrone ("ALL-2') to A Standard Vincristine/Prednisone Based Regimen ('L-20') as Induction Therapy For Adult Patients With Acute Lymphoblastic Leukemia (ALL): The ALL-4 Protocol Completed NCT00002766 Phase 3 carmustine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;doxorubicin hydrochloride;etoposide;mercaptopurine;methotrexate;mitoxantrone hydrochloride;pegaspargase;prednisone;vincristine sulfate
3 High Risk B-Precursor Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
4 Intensified Tyrosine Kinase Inhibitor Therapy (Dasatinib NSC# 732517) in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (ALL) Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
5 A Randomized Trial for Adults With Newly Diagnosed Acute Lymphoblastic Leukemia Recruiting NCT01085617 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;etoposide;fludarabine phosphate;imatinib mesylate;melphalan;mercaptopurine;methotrexate;nelarabine;pegaspargase;vincristine sulfate
6 MULTICENTRE TRIAL OF INTENSIFIED THERAPY FOR ADULT ALL (O5/93) Unknown status NCT00002531 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;teniposide;thioguanine;vincristine sulfate;vindesine
7 Phase II Study of Adult Acute Lymphoblastic Leukaemia (ALL): Imatinib in Combination With Chemotherapy in Ph+ Patients, and Post-remissional Treatment Intensification in High-risk Ph- Patients, With Minimal Residual Disease Monitoring. Completed NCT00458848 Phase 2 asparaginase;daunorubicin hydrochloride;etoposide;idarubicin;imatinib mesylate;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisone;vincristine sulfate
8 A Phase II Trial of 506U78 (IND 52611) in Patients With Relapsed or Refractory Non T-cell Acute Lymphoblastic Leukemia (ALL) Completed NCT00006020 Phase 2 nelarabine
9 A Phase II Study of Subcutaneous Bortezomib in Combination With Chemotherapy (VXLD) for Relapsed/Refractory Adult Acute Lymphoblastic Leukemia Completed NCT01769209 Phase 2 Bortezomib;Doxorubicin hydrochloride (HCl);PEG-Asparaginase;Vincristine sulfate;Dexamethasone;Cytarabine;Methotrexate
10 Addition of Pre- and Post-Transplant Rituximab for Patients Undergoing Non-myeloablative Allogeneic Hematopoietic Cell Transplantation With Relapsed or Refractory CD20+ B-Cell Malignancies Completed NCT00867529 Phase 2
11 A Phase I/II Study of Combined Enrichment of CD34+ Cells and Depletion of B-Cells From Peripheral Blood Stem Cell Components for Patients With B-Lymphoid Malignancies Completed NCT00003874 Phase 1, Phase 2
12 S0910, A Phase II Study of Epratuzumab (NSC-716711) in Combination With Cytarabine and Clofarabine for Patients With Relapsed or Refractory Ph- Negative Precursor B-Cell Acute Lymphoblastic Leukemia Completed NCT00945815 Phase 2 clofarabine;cytarabine
13 A Phase II Trial of Cytarabine and Clofarabine in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) Completed NCT00337168 Phase 2 clofarabine;cytarabine
14 Phase I/II Radioimmunotherapy of Non-Hodgkin's Lymphoma With High-Dose 90Y-Labeled Humanized LL2 Anti-CD-22 Antibody and Peripheral Blood Stem Cell Rescue Completed NCT00004107 Phase 1, Phase 2
15 Phase II Trial of Intensive, Short-Course Combination Chemotherapy in the Treatment of Newly Diagnosed Patients With Poor-Risk Nonlymphoblastic Lymphoma and Acute B-Lymphoblastic Leukemia and in Patients With Recurrent Non-Hodgkin's Lymphoma Completed NCT00002471 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;methotrexate;methylprednisolone;therapeutic hydrocortisone;thiotepa;vincristine sulfate
16 A Phase II Pilot Trial of Bortezomib (PS-341, Velcade) in Combination With Intensive Re-Induction Therapy for Children With Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL) Completed NCT00873093 Phase 2 L-asparaginase;doxorubicin hydrochloride;therapeutic hydrocortisone;vincristine sulfate;cytarabine;prednisone;bortezomib;pegaspargase;methotrexate;etoposide phosphate;cyclophosphamide;leucovorin calcium;High Dose MTX
17 A Phase 1b/2a Study of ABT-888 in Combination With Bendamustine +/- Rituximab in Lymphoma, Multiple Myeloma and Solid Tumors Completed NCT01326702 Phase 1, Phase 2 Bendamustine Hydrochloride;Veliparib
18 A Phase 2 Study of Ibrutinib and Blinatumomab in Relapsed and Refractory B-Cell Acute Lymphoblastic Leukemia Recruiting NCT02997761 Phase 2 Ibrutinib
19 An Intergroup Phase II Clinical Trial for Adolescents and Young Adults With Untreated Acute Lymphoblastic Leukemia (ALL) Active, not recruiting NCT00558519 Phase 2 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
20 Blinatumomab for Minimal Residual Disease (MRD) in Pre-B Cell Acute Lymphoblastic Leukemia Patients Following Hematopoietic Cell Transplantation: A Canadian, Multicentre Trial Not yet recruiting NCT04044560 Phase 2
21 A Phase 2 Study to Determine the Efficacy of the BTK Inhibitor Ibrutinib (PCI-32765) in Patients With Relapsed or Refractory Precursor-B Lymphoblastic Leukemia (B-ALL) Terminated NCT02129062 Phase 2 Ibrutinib
22 A Phase I/II Trial of Romidepsin, Rituximab and Lenalidomide (R3) in Relapsed/Refractory B Cell Lymphomas Including Transformed Follicular Lymphoma Withdrawn NCT02281279 Phase 1, Phase 2 lenalidomide;romidepsin
23 A Phase II Study of Combination Nilotinib and Hyper-CVAD in Patients Newly Diagnosed With Philadelphia-Chromosome Positive Acute Lymphoblastic Leukemia or Chronic Myeloid Leukemia Blast-Phase Lymphoid Lineage Withdrawn NCT01670084 Phase 2 nilotinib;cyclophosphamide;doxorubicin hydrochloride;vincristine sulfate;methotrexate;cytarabine;prednisone;mesna;dexamethasone;leucovorin calcium
24 A Phase I Study of Combination Therapy With Anti-CD19 and Anti-CD22 Immunotoxins (Combotox) in Adults With Refractory/Relapse Acute Lymphoblastic Leukemia Unknown status NCT00450944 Phase 1
25 A Phase 1 Study of the Deglycosylated Ricin A Chain-containing Combined Anti-CD19 and Anti-CD22 Immunotoxin Combotox in Combination With High-Dose Cytarabine in Adult Relapsed or Refractory B-lineage Acute Lymphoblastic Leukemia Unknown status NCT01408160 Phase 1 Cytarabine
26 A Phase I Trial Of Rituximab And Interleukin-2 Completed NCT00010192 Phase 1
27 Phase I Study of the Aurora Kinase a Inhibitor MLN8237 in Combination With the Histone Deacetylase Inhibitor Vorinostat in Lymphoid Malignancies Completed NCT01567709 Phase 1 Alisertib;Vorinostat
28 Phase I Study of Adoptive Immunotherapy With CD8 Minor Histocompatibility (H) Antigen-Specific CTL Clones for Patients With Relapsed of AML or ALL After Allogeneic Hematopoietic Stem Cell Transplant Completed NCT00107354 Phase 1 cytarabine;etoposide;mitoxantrone hydrochloride
29 A Phase I Study of DT2219ARL, A Bispecific Singe Chain Immunotoxin for the Treatment of Relapsed or Refractory CD19(+), CD22(+) B-Lineage Leukemia or Lymphoma Completed NCT00889408 Phase 1
30 A Phase I Study of Photochemically Treated Donor T-Cell Supplements in HLA Haplotype Mismatched Hematopoietic Stem Cell Transplantation Completed NCT00005092 Phase 1 Cyclophosphamide;Psoralen;Thiotepa
31 A Phase I Trial of Palbociclib in Combination With Dexamethasone in Relapsed or Refractory Adult B-Cell Acute Lymphoblastic Leukemia (ALL) Recruiting NCT03472573 Phase 1 Palbociclib;Dexamethasone
32 A Two-Stage Phase 1 Open-Label Study of huJCAR014, CD19-Targeted Chimeric Antigen Receptor (CAR)-Modified T Cells Bearing a Human Binding Domain, in Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma and Acute Lymphocytic Leukemia Recruiting NCT03103971 Phase 1 Cyclophosphamide;Fludarabine
33 Phase I Study to Evaluate Cellular Immunotherapy Using Memory-Enriched T Cells Lentivirally Transduced to Express a CD19-Specific, Hinge-Optimized, CD28-Costimulatory Chimeric Receptor and a Truncated EGFR Following Lymphodepleting Chemotherapy in Adult Patients With High-Risk CD19+ Acute Lymphoblastic Leukemia Recruiting NCT02146924 Phase 1
34 Phase I Study of MLN 9708 in Addition to Chemotherapy for the Treatment of Acute Lymphoblastic Leukemia in Older Adults Active, not recruiting NCT02228772 Phase 1 MLN 9708;Vincristine;Cytarabine;Doxorubicin;Mercaptopurine;Cyclophosphamide;Methotrexate
35 A Phase I Study of Administrating CD19 Chimeric Antigen Receptor Expressing T Cells Followed by Allogeneic Stem Cell Transplantation in Patients With Refractory CD19+ B-linage Leukemia/Lymphoma Not yet recruiting NCT03110640 Phase 1 Fludarabine;Cyclophosphamide
36 Phase I Dose-Escalation Study of CPI-613, in Combination With Bendamustine and Rituximab, in Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma Terminated NCT02168907 Phase 1 6,8-bis(benzylthio)octanoic acid;bendamustine hydrochloride
37 Phase I and Pharmacokinetic Study of Ibrutinib in HIV-Infected Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Multiple Myeloma Terminated NCT02109224 Phase 1 Ibrutinib
38 Genomic Analysis of Adolescent and Young Adult Acute Lymphoblastic Leukemia Unknown status NCT01653613
39 Micro RNA Expression Analysis in B-Lineage Adult Acute Lymphoblastic Leukemia From ALL Trial, E2993, Including Patients With Various Cytogenetic and Molecular Abnormalities Completed NCT01505699
40 Identifying Rare Genetic Variants Involved in High Risk Acute Lymphoblastic Leukemia (ALL) Via Pooled DNA Sequencing Completed NCT01119586
41 Young Adult Acute Lymphoid Leukemia (ALL): Intensification of Pediatric AIEOP LLA-2000 Treatment Completed NCT01156883 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;ifosfamide;mercaptopurine;methotrexate;methylprednisolone;prednisone;thioguanine;vincristine sulfate;vindesine
42 Intensified PEG-Asparaginase in High Risk Acute Lymphoblastic Leukemia (ALL): A Pilot Study Completed NCT00866307 pegaspargase;cytarabine;vincristine sulfate;doxorubicin hydrochloride;cyclophosphamide;prednisone;dexamethasone;methotrexate;daunorubicin hydrochloride;mercaptopurine;thioguanine
43 A Pilot Study of Intravenous EZN-2285 (SC-PEG E. Coli L-asparaginase, IND# 100594) or Intravenous Oncaspar® in the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia (ALL) Completed NCT00671034 calaspargase pegol;calaspargase pegol;Pegaspargase;DOXOrubicin Hydrochloride;Cytarabine;Prednisone;methotrexate;cyclophosphamide;mercaptopurine tablet;Dexamethasone;thioguanine;DAUNOrubicin Hydrochloride;vincristine sulfate
44 Multicenter Trial Treatment of Philadelphia Chromosome Negative (Ph-) B-lineage Acute Lymphoblastic Leukemia (ALL) of Young Adults (18-59 Years). Recruiting NCT02617004

Search NIH Clinical Center for B-Cell Adult Acute Lymphocytic Leukemia

Sources

Genetic Tests for B-Cell Adult Acute Lymphocytic Leukemia

About this section
Sources

Anatomical Context for B-Cell Adult Acute Lymphocytic Leukemia

About this section

MalaCards organs/tissues related to B-Cell Adult Acute Lymphocytic Leukemia:

41
B Cells, B Lymphoblasts, T Cells, Bone, Myeloid
Sources

Publications for B-Cell Adult Acute Lymphocytic Leukemia

About this section

Articles related to B-Cell Adult Acute Lymphocytic Leukemia:

# Title Authors PMID Year
1
Suppression of miR-708 inhibits the Wnt/β-catenin signaling pathway by activating DKK3 in adult B-all. 38
28969056 2017
2
Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. 38
26942999 2016
3
Development-associated immunophenotypes reveal the heterogeneous and individualized early responses of adult B-acute lymphoblastic leukemia. 38
27559941 2016
4
Monoclonal antibodies and immune therapies for adult precursor B-acute lymphoblastic leukemia. 38
26921100 2016
5
Prognostic significance of MSI2 predicts unfavorable outcome in adult B-acute lymphoblastic leukemia. 38
25090928 2015
6
BCR-ABL1 and CD66c exhibit high concordance in minimal residual disease detection of adult B-acute lymphoblastic leukemia. 38
26045902 2015
7
Prognostic significance of monitoring leukemia-associated immunophenotypes by eight-color flow cytometry in adult B-acute lymphoblastic leukemia. 38
23955588 2013
8
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. 38
23107779 2012
9
Fingerprinting acute leukemia: DNA methylation profiling of B-acute lymphoblastic leukemia. 38
23148371 2012
Sources

Variations for B-Cell Adult Acute Lymphocytic Leukemia

About this section
Sources

Expression for B-Cell Adult Acute Lymphocytic Leukemia

About this section
Search GEO for disease gene expression data for B-Cell Adult Acute Lymphocytic Leukemia.
Sources

Pathways for B-Cell Adult Acute Lymphocytic Leukemia

About this section

Pathways related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.44 PBX1 PAX5 IKZF3 IKZF1
2
B Cell Development Pathways 65
10.68 PAX5 IL21R
Sources

GO Terms for B-Cell Adult Acute Lymphocytic Leukemia

About this section

Biological processes related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.56 PBX1 PAX5 IKZF3 IKZF1
2 animal organ morphogenesis GO:0009887 9.32 PBX1 PAX5
3 thymus development GO:0048538 9.16 PBX1 ABL1
4 mesoderm development GO:0007498 8.96 IKZF3 IKZF1
5 spleen development GO:0048536 8.62 PBX1 ABL1

Molecular functions related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.35 PBX1 PAX5 IKZF3 IKZF1 ABL1
2 DNA-binding transcription factor activity GO:0003700 8.92 PBX1 PAX5 IKZF3 IKZF1
Sources

Sources for B-Cell Adult Acute Lymphocytic Leukemia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....