MCID: BCL013
MIFTS: 35

B-Cell Adult Acute Lymphocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for B-Cell Adult Acute Lymphocytic Leukemia

MalaCards integrated aliases for B-Cell Adult Acute Lymphocytic Leukemia:

Name: B-Cell Adult Acute Lymphocytic Leukemia 12 15
Adult B Acute Lymphoblastic Leukemia 12 17
Adult B-Cell Acute Lymphoblastic Leukemia 12
B-Cell Adult Acute Lymphoblastic Leukemia 74
Adult B-Cell Lymphocytic Leukemia 12
Adult B-Lymphoblastic Leukemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060592
NCIt 51 C9143
UMLS 74 C0279593

Summaries for B-Cell Adult Acute Lymphocytic Leukemia

MalaCards based summary : B-Cell Adult Acute Lymphocytic Leukemia, also known as adult b acute lymphoblastic leukemia, is related to leukemia, acute lymphoblastic and leukemia, and has symptoms including bone pain An important gene associated with B-Cell Adult Acute Lymphocytic Leukemia is IKZF1 (IKAROS Family Zinc Finger 1), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs Cytarabine and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include b cells, b lymphoblasts and bone, and related phenotypes are hematopoietic system and immune system

Related Diseases for B-Cell Adult Acute Lymphocytic Leukemia

Diseases in the B-Cell Adult Acute Lymphocytic Leukemia family:

T-Cell Adult Acute Lymphocytic Leukemia

Diseases related to B-Cell Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 30.5 PAX5 ABL1
2 leukemia 10.4
3 lymphocytic leukemia 10.4
4 acute lymphocytic leukemia 10.1
5 myelodysplastic syndrome 10.1
6 hematopoietic stem cell transplantation 10.1
7 neutropenia 10.1
8 precursor t-cell acute lymphoblastic leukemia 9.8 IKZF1 ABL1
9 childhood leukemia 9.8 PBX1 ABL1
10 hematologic cancer 9.7 PAX5 IKZF1 ABL1
11 leukemia, acute lymphoblastic 3 9.3 PBX1 PAX5 IKZF1 ABL1

Graphical network of the top 20 diseases related to B-Cell Adult Acute Lymphocytic Leukemia:



Diseases related to B-Cell Adult Acute Lymphocytic Leukemia

Symptoms & Phenotypes for B-Cell Adult Acute Lymphocytic Leukemia

UMLS symptoms related to B-Cell Adult Acute Lymphocytic Leukemia:


bone pain

MGI Mouse Phenotypes related to B-Cell Adult Acute Lymphocytic Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
2 immune system MP:0005387 9.63 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
3 mortality/aging MP:0010768 9.43 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
4 neoplasm MP:0002006 8.92 IKZF1 IKZF3 MSI2 PAX5

Drugs & Therapeutics for B-Cell Adult Acute Lymphocytic Leukemia

Drugs for B-Cell Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 125)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Experimental, Investigational Phase 2, Phase 3,Phase 1 147-94-4, 65-46-3 6253
2
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
3
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
4
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
5
Mercaptopurine Approved Phase 2, Phase 3 50-44-2 667490
6
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
7
Ichthammol Approved Phase 2, Phase 3 8029-68-3
8
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
10
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
11
Vincristine Approved, Investigational Phase 2, Phase 3 2068-78-2, 57-22-7 5978
12
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
13
Pegaspargase Approved, Investigational Phase 2, Phase 3 130167-69-0
14
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
15
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
16
leucovorin Approved Phase 2, Phase 3,Phase 3 58-05-9 6006 143
17
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
18
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
19
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
20
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
21
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1 6055-19-2, 50-18-0 2907
22
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
23
Sargramostim Approved, Investigational Phase 2, Phase 3 123774-72-1, 83869-56-1
24
Dasatinib Approved, Investigational Phase 2, Phase 3,Phase 1 302962-49-8 3062316
25
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
26
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
27
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
28
Emodepside Investigational, Vet_approved Phase 2, Phase 3,Phase 1 155030-63-0
29
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
30
Cortisone Experimental Phase 2, Phase 3 53-06-5 222786
31 Immunosuppressive Agents Phase 2, Phase 3,Phase 1
32 Immunologic Factors Phase 2, Phase 3,Phase 1
33 Antimetabolites Phase 2, Phase 3,Phase 1
34 Anti-Infective Agents Phase 2, Phase 3,Phase 1
35 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 1
36 Antiviral Agents Phase 2, Phase 3,Phase 1
37 Vitamins Phase 2, Phase 3
38 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
39 BB 1101 Phase 2, Phase 3
40 HIV Protease Inhibitors Phase 2, Phase 3
41 Nutrients Phase 2, Phase 3
42 Protective Agents Phase 2, Phase 3
43 Bone Density Conservation Agents Phase 2, Phase 3
44 Topoisomerase Inhibitors Phase 2, Phase 3
45 Hydrocortisone-17-butyrate Phase 2, Phase 3
46 Hydrocortisone 17-butyrate 21-propionate Phase 2, Phase 3
47
asparaginase Phase 2, Phase 3
48 Hormone Antagonists Phase 2, Phase 3
49 Antineoplastic Agents, Hormonal Phase 2, Phase 3
50
Isophosphamide mustard Phase 2, Phase 3 0

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
2 Ibrutinib and Blinatumomab in Treating Patients With Relapsed or Refractory B Acute Lymphoblastic Leukemia Recruiting NCT02997761 Phase 2 Ibrutinib
3 Ibrutinib in Treating Patients With Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia Terminated NCT02129062 Phase 2 Ibrutinib
4 Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Active, not recruiting NCT01256398 Phase 2 Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide Phosphate;Fludarabine Phosphate;Leucovorin Calcium;Melphalan;Mercaptopurine;Methotrexate;Tacrolimus;Vincristine Sulfate
5 Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia Active, not recruiting NCT00792948 Phase 2 Cyclophosphamide;Cytarabine;Dasatinib;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Leucovorin Calcium;Methotrexate;Methylprednisolone;Prednisone;Sirolimus;Tacrolimus;Vincristine Sulfate
6 Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors Completed NCT01326702 Phase 1, Phase 2 Bendamustine Hydrochloride;Veliparib
7 Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Dasatinib, or Nilotinib Active, not recruiting NCT00036738 Phase 2 Cyclosporine;Dasatinib;Fludarabine Phosphate;Imatinib Mesylate;Mycophenolate Mofetil;Nilotinib
8 Immunotoxin Therapy and Cytarabine in Treating Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Unknown status NCT01408160 Phase 1 Cytarabine
9 Veliparib and Temozolomide in Treating Patients With Acute Leukemia Active, not recruiting NCT01139970 Phase 1 Temozolomide;Veliparib
10 huJCAR014 CAR-T Cells in Treating Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia Recruiting NCT03103971 Phase 1 Cyclophosphamide;Fludarabine
11 Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection Terminated NCT02109224 Phase 1 Ibrutinib
12 Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma Completed NCT01567709 Phase 1 Alisertib;Vorinostat
13 Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery Completed NCT00608361 Phase 1 Dasatinib

Search NIH Clinical Center for B-Cell Adult Acute Lymphocytic Leukemia

Genetic Tests for B-Cell Adult Acute Lymphocytic Leukemia

Anatomical Context for B-Cell Adult Acute Lymphocytic Leukemia

MalaCards organs/tissues related to B-Cell Adult Acute Lymphocytic Leukemia:

42
B Cells, B Lymphoblasts, Bone, T Cells, Liver

Publications for B-Cell Adult Acute Lymphocytic Leukemia

Articles related to B-Cell Adult Acute Lymphocytic Leukemia:

# Title Authors Year
1
Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. ( 26942999 )
2016
2
Development-associated immunophenotypes reveal the heterogeneous and individualized early responses of adult B-acute lymphoblastic leukemia. ( 27559941 )
2016
3
Prognostic significance of MSI2 predicts unfavorable outcome in adult B-acute lymphoblastic leukemia. ( 25090928 )
2015
4
BCR-ABL1 and CD66c exhibit high concordance in minimal residual disease detection of adult B-acute lymphoblastic leukemia. ( 26045902 )
2015
5
Prognostic significance of monitoring leukemia-associated immunophenotypes by eight-color flow cytometry in adult B-acute lymphoblastic leukemia. ( 23955588 )
2013
6
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. ( 23107779 )
2012

Variations for B-Cell Adult Acute Lymphocytic Leukemia

Expression for B-Cell Adult Acute Lymphocytic Leukemia

Search GEO for disease gene expression data for B-Cell Adult Acute Lymphocytic Leukemia.

Pathways for B-Cell Adult Acute Lymphocytic Leukemia

Pathways related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 IKZF1 IKZF3 PAX5 PBX1

GO Terms for B-Cell Adult Acute Lymphocytic Leukemia

Cellular components related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.02 ABL1 IKZF1 IKZF3 PAX5 PBX1

Biological processes related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.56 IKZF1 IKZF3 PAX5 PBX1
2 animal organ morphogenesis GO:0009887 9.32 PAX5 PBX1
3 thymus development GO:0048538 9.16 ABL1 PBX1
4 transcription by RNA polymerase II GO:0006366 9.07 PAX5
5 mesoderm development GO:0007498 8.96 IKZF1 IKZF3
6 spleen development GO:0048536 8.62 ABL1 PBX1

Molecular functions related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.46 IKZF1 IKZF3 PAX5 PBX1
2 DNA binding GO:0003677 9.35 ABL1 IKZF1 IKZF3 PAX5 PBX1
3 DNA-binding transcription factor activity GO:0003700 8.92 IKZF1 IKZF3 PAX5 PBX1

Sources for B-Cell Adult Acute Lymphocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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