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MCID: BCL013
MIFTS: 35

B-Cell Adult Acute Lymphocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for B-Cell Adult Acute Lymphocytic Leukemia

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MalaCards integrated aliases for B-Cell Adult Acute Lymphocytic Leukemia:

Name: B-Cell Adult Acute Lymphocytic Leukemia 12 15
Adult B Acute Lymphoblastic Leukemia 12 17
Adult B-Cell Acute Lymphoblastic Leukemia 12
B-Cell Adult Acute Lymphoblastic Leukemia 74
Adult B-Cell Lymphocytic Leukemia 12
Adult B-Lymphoblastic Leukemia 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0060592
NCIt 51 C9143
UMLS 74 C0279593
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Summaries for B-Cell Adult Acute Lymphocytic Leukemia

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MalaCards based summary : B-Cell Adult Acute Lymphocytic Leukemia, also known as adult b acute lymphoblastic leukemia, is related to leukemia, acute lymphoblastic and leukemia, and has symptoms including bone pain An important gene associated with B-Cell Adult Acute Lymphocytic Leukemia is IKZF1 (IKAROS Family Zinc Finger 1), and among its related pathways/superpathways is NF-kappaB Signaling. The drugs Cytarabine and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include b cells, b lymphoblasts and t cells, and related phenotypes are hematopoietic system and immune system

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Related Diseases for B-Cell Adult Acute Lymphocytic Leukemia

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Diseases in the B-Cell Adult Acute Lymphocytic Leukemia family:

T-Cell Adult Acute Lymphocytic Leukemia

Diseases related to B-Cell Adult Acute Lymphocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute lymphoblastic 30.5 ABL1 PAX5
2 leukemia 10.4
3 lymphocytic leukemia 10.4
4 acute lymphocytic leukemia 10.2
5 myelodysplastic syndrome 10.1
6 hematopoietic stem cell transplantation 10.1
7 neutropenia 10.1
8 precursor t-cell acute lymphoblastic leukemia 9.8 ABL1 IKZF1
9 childhood leukemia 9.8 ABL1 PBX1
10 hematologic cancer 9.7 ABL1 IKZF1 PAX5
11 leukemia, acute lymphoblastic 3 9.3 ABL1 IKZF1 PAX5 PBX1

Graphical network of the top 20 diseases related to B-Cell Adult Acute Lymphocytic Leukemia:



Diseases related to B-Cell Adult Acute Lymphocytic Leukemia
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Symptoms & Phenotypes for B-Cell Adult Acute Lymphocytic Leukemia

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UMLS symptoms related to B-Cell Adult Acute Lymphocytic Leukemia:


bone pain

MGI Mouse Phenotypes related to B-Cell Adult Acute Lymphocytic Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
2 immune system MP:0005387 9.63 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
3 mortality/aging MP:0010768 9.43 ABL1 IKZF1 IKZF3 MSI2 PAX5 PBX1
4 neoplasm MP:0002006 8.92 IKZF1 IKZF3 MSI2 PAX5
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Drugs & Therapeutics for B-Cell Adult Acute Lymphocytic Leukemia

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Drugs for B-Cell Adult Acute Lymphocytic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 125)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Experimental, Investigational Phase 2, Phase 3,Phase 1 147-94-4, 65-46-3 6253
2
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
3
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
5
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 1177-87-3
7
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
8
Dasatinib Approved, Investigational Phase 2, Phase 3,Phase 1 302962-49-8 3062316
9
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
10
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754
11
Pegaspargase Approved, Investigational Phase 2, Phase 3 130167-69-0
12
leucovorin Approved Phase 2, Phase 3,Phase 3 58-05-9 143 6006
13
Hydrocortisone acetate Approved, Vet_approved Phase 2, Phase 3 50-03-3
14
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
15
Mercaptopurine Approved Phase 2, Phase 3 50-44-2 667490
16
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
17
Vincristine Approved, Investigational Phase 2, Phase 3 2068-78-2, 57-22-7 5978
18
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
19
Etoposide Approved Phase 2, Phase 3 33419-42-0 36462
20
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
21
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
22
Sargramostim Approved, Investigational Phase 2, Phase 3 123774-72-1, 83869-56-1
23
Ichthammol Approved Phase 2, Phase 3 8029-68-3
24
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 1 50-18-0, 6055-19-2 2907
25
Levoleucovorin Approved, Investigational Phase 2, Phase 3 68538-85-2
26
Tyrosine Approved, Investigational, Nutraceutical Phase 2, Phase 3 60-18-4 6057
27
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
28
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
29
Cortisone Experimental Phase 2, Phase 3 53-06-5 222786
30
Prednisolone hemisuccinate Experimental Phase 2, Phase 3 2920-86-7
31
Emodepside Investigational, Vet_approved Phase 2, Phase 3,Phase 1 155030-63-0
32 Antimetabolites Phase 2, Phase 3,Phase 1
33 Antiviral Agents Phase 2, Phase 3,Phase 1
34 Immunosuppressive Agents Phase 2, Phase 3,Phase 1
35 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 1
36 Immunologic Factors Phase 2, Phase 3,Phase 1
37 Anti-Infective Agents Phase 2, Phase 3,Phase 1
38 Micronutrients Phase 2, Phase 3
39 Anti-Inflammatory Agents Phase 2, Phase 3
40 Trace Elements Phase 2, Phase 3
41 Hormone Antagonists Phase 2, Phase 3
42 Antineoplastic Agents, Phytogenic Phase 2, Phase 3
43 Hydrocortisone 17-butyrate 21-propionate Phase 2, Phase 3
44 Antineoplastic Agents, Hormonal Phase 2, Phase 3
45 Antirheumatic Agents Phase 2, Phase 3,Phase 1
46 Methylprednisolone Acetate Phase 2, Phase 3
47 Folic Acid Antagonists Phase 2, Phase 3
48 Hormones Phase 2, Phase 3
49 Neuroprotective Agents Phase 2, Phase 3
50 Keratolytic Agents Phase 2, Phase 3

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
2 Veliparib, Bendamustine Hydrochloride, and Rituximab in Treating Patients With Relapsed or Refractory Lymphoma, Multiple Myeloma, or Solid Tumors Completed NCT01326702 Phase 1, Phase 2 Bendamustine Hydrochloride;Veliparib
3 Ibrutinib and Blinatumomab in Treating Patients With Relapsed or Refractory B Acute Lymphoblastic Leukemia Recruiting NCT02997761 Phase 2 Ibrutinib
4 Dasatinib Followed by Stem Cell Transplant in Treating Older Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Active, not recruiting NCT01256398 Phase 2 Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide Phosphate;Fludarabine Phosphate;Leucovorin Calcium;Melphalan;Mercaptopurine;Methotrexate;Tacrolimus;Vincristine Sulfate
5 Combination Chemotherapy With or Without Donor Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia Active, not recruiting NCT00792948 Phase 2 Cyclophosphamide;Cytarabine;Dasatinib;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Leucovorin Calcium;Methotrexate;Methylprednisolone;Prednisone;Sirolimus;Tacrolimus;Vincristine Sulfate
6 Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Dasatinib, or Nilotinib Active, not recruiting NCT00036738 Phase 2 Cyclosporine;Dasatinib;Fludarabine Phosphate;Imatinib Mesylate;Mycophenolate Mofetil;Nilotinib
7 Ibrutinib in Treating Patients With Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia Terminated NCT02129062 Phase 2 Ibrutinib
8 Immunotoxin Therapy and Cytarabine in Treating Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Unknown status NCT01408160 Phase 1 Cytarabine
9 Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma Completed NCT01567709 Phase 1 Alisertib;Vorinostat
10 Dasatinib in Treating Patients With Solid Tumors or Lymphomas That Are Metastatic or Cannot Be Removed By Surgery Completed NCT00608361 Phase 1 Dasatinib
11 huJCAR014 CAR-T Cells in Treating Adult Patients With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma or Acute Lymphoblastic Leukemia Recruiting NCT03103971 Phase 1 Cyclophosphamide;Fludarabine
12 Veliparib and Temozolomide in Treating Patients With Acute Leukemia Active, not recruiting NCT01139970 Phase 1 Temozolomide;Veliparib
13 Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With HIV Infection Terminated NCT02109224 Phase 1 Ibrutinib

Search NIH Clinical Center for B-Cell Adult Acute Lymphocytic Leukemia

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Genetic Tests for B-Cell Adult Acute Lymphocytic Leukemia

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Anatomical Context for B-Cell Adult Acute Lymphocytic Leukemia

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MalaCards organs/tissues related to B-Cell Adult Acute Lymphocytic Leukemia:

42
B Cells, B Lymphoblasts, T Cells, Bone, Liver
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Publications for B-Cell Adult Acute Lymphocytic Leukemia

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Articles related to B-Cell Adult Acute Lymphocytic Leukemia:

# Title Authors Year
1
Development-associated immunophenotypes reveal the heterogeneous and individualized early responses of adult B-acute lymphoblastic leukemia. ( 27559941 )
2016
2
Atypical BCR-ABL1 fusion transcripts in adult B-acute lymphoblastic leukemia, including a novel fusion transcript-e8a1. ( 26942999 )
2016
3
BCR-ABL1 and CD66c exhibit high concordance in minimal residual disease detection of adult B-acute lymphoblastic leukemia. ( 26045902 )
2015
4
Prognostic significance of MSI2 predicts unfavorable outcome in adult B-acute lymphoblastic leukemia. ( 25090928 )
2015
5
Prognostic significance of monitoring leukemia-associated immunophenotypes by eight-color flow cytometry in adult B-acute lymphoblastic leukemia. ( 23955588 )
2013
6
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. ( 23107779 )
2012
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Variations for B-Cell Adult Acute Lymphocytic Leukemia

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Expression for B-Cell Adult Acute Lymphocytic Leukemia

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Search GEO for disease gene expression data for B-Cell Adult Acute Lymphocytic Leukemia.
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Pathways for B-Cell Adult Acute Lymphocytic Leukemia

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Pathways related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
11.44 IKZF1 IKZF3 PAX5 PBX1
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GO Terms for B-Cell Adult Acute Lymphocytic Leukemia

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Cellular components related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.02 ABL1 IKZF1 IKZF3 PAX5 PBX1

Biological processes related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.56 IKZF1 IKZF3 PAX5 PBX1
2 animal organ morphogenesis GO:0009887 9.32 PAX5 PBX1
3 thymus development GO:0048538 9.16 ABL1 PBX1
4 transcription by RNA polymerase II GO:0006366 9.07 PAX5
5 mesoderm development GO:0007498 8.96 IKZF1 IKZF3
6 spleen development GO:0048536 8.62 ABL1 PBX1

Molecular functions related to B-Cell Adult Acute Lymphocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.46 IKZF1 IKZF3 PAX5 PBX1
2 DNA binding GO:0003677 9.35 ABL1 IKZF1 IKZF3 PAX5 PBX1
3 DNA-binding transcription factor activity GO:0003700 8.92 IKZF1 IKZF3 PAX5 PBX1
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Sources for B-Cell Adult Acute Lymphocytic Leukemia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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