MCID: BCL008
MIFTS: 35

B-Cell Childhood Acute Lymphoblastic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for B-Cell Childhood Acute Lymphoblastic Leukemia

MalaCards integrated aliases for B-Cell Childhood Acute Lymphoblastic Leukemia:

Name: B-Cell Childhood Acute Lymphoblastic Leukemia 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0080146
NCIt 51 C9140
UMLS 74 C0279584

Summaries for B-Cell Childhood Acute Lymphoblastic Leukemia

Disease Ontology : 12 A childhood acute lymphoblastic leukemia that has_material_basis in B-cells.

MalaCards based summary : B-Cell Childhood Acute Lymphoblastic Leukemia is related to leukemia, acute lymphoblastic and acute lymphoblastic leukemia, childhood, and has symptoms including bone pain An important gene associated with B-Cell Childhood Acute Lymphoblastic Leukemia is RUNX1 (RUNX Family Transcription Factor 1), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Innate Lymphoid Cell Differentiation Pathways. The drugs Cytarabine and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include b cells, myeloid and bone, and related phenotypes are Reduced mammosphere formation and cellular

Related Diseases for B-Cell Childhood Acute Lymphoblastic Leukemia

Graphical network of the top 20 diseases related to B-Cell Childhood Acute Lymphoblastic Leukemia:



Diseases related to B-Cell Childhood Acute Lymphoblastic Leukemia

Symptoms & Phenotypes for B-Cell Childhood Acute Lymphoblastic Leukemia

UMLS symptoms related to B-Cell Childhood Acute Lymphoblastic Leukemia:


bone pain

GenomeRNAi Phenotypes related to B-Cell Childhood Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.8 ETV6 IKZF1 RUNX1

MGI Mouse Phenotypes related to B-Cell Childhood Acute Lymphoblastic Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 CEBPE ETV6 IKZF1 RUNX1
2 hematopoietic system MP:0005397 9.67 CEBPE ETV6 IKZF1 RUNX1
3 immune system MP:0005387 9.62 CEBPE ETV6 IKZF1 RUNX1
4 digestive/alimentary MP:0005381 9.58 CEBPE ETV6 IKZF1
5 integument MP:0010771 9.56 CEBPE ETV6 IKZF1 RUNX1
6 neoplasm MP:0002006 9.33 ETV6 IKZF1 RUNX1
7 no phenotypic analysis MP:0003012 9.13 ETV6 IKZF1 RUNX1
8 respiratory system MP:0005388 8.8 CEBPE IKZF1 RUNX1

Drugs & Therapeutics for B-Cell Childhood Acute Lymphoblastic Leukemia

Drugs for B-Cell Childhood Acute Lymphoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 147-94-4, 65-46-3 6253
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
3
Idarubicin Approved Phase 4,Phase 2 58957-92-9 42890
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
5
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
6
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
7
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 20830-81-3 30323
8 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9
asparaginase Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
15
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
16
Prednisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 53-03-2 5865
17
Vindesine Approved, Investigational Phase 3 53643-48-4, 59917-39-4 40839
18
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 68538-85-2
19
Thioguanine Approved Phase 3,Phase 2,Not Applicable 154-42-7 2723601
20
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
21
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
22
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
23
Mercaptopurine Approved Phase 3,Phase 2,Phase 1,Not Applicable 50-44-2 667490
24
Tacrolimus Approved, Investigational Phase 3 104987-11-3 6473866 445643 439492
25
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 3,Phase 1 53123-88-9 46835353 5284616 6436030
27
Everolimus Approved Phase 3,Phase 1 159351-69-6 70789204 6442177
28
Thiotepa Approved, Investigational Phase 3,Phase 2,Phase 1 52-24-4 5453
29
Prednisolone phosphate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 302-25-0
30
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-23-7 5754
31
Prednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-24-8 5755
32
Mitoxantrone Approved, Investigational Phase 3,Phase 2,Phase 1 65271-80-9 4212
33
Methylprednisolone hemisuccinate Approved Phase 3,Phase 2,Not Applicable 2921-57-5
34
Hydrocortisone acetate Approved, Vet_approved Phase 3,Phase 2,Not Applicable 50-03-3
35
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2,Not Applicable 83-43-2 6741
36
Pegaspargase Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 130167-69-0
37
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
38
Dasatinib Approved, Investigational Phase 2, Phase 3 302962-49-8 3062316
39
Mechlorethamine Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 51-75-2 4033
40
Sargramostim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 123774-72-1, 83869-56-1
41
Ichthammol Approved Phase 2, Phase 3,Phase 3,Phase 1 8029-68-3
42
Calcium Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
43
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 59-30-3 6037
44
Tyrosine Approved, Investigational, Nutraceutical Phase 2, Phase 3 60-18-4 6057
45
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1,Not Applicable 31703
46
Prednisolone hemisuccinate Experimental Phase 3,Phase 2,Not Applicable 2920-86-7
47
Cortisone Experimental Phase 2, Phase 3 53-06-5 222786
48
Emodepside Investigational, Vet_approved Phase 2, Phase 3,Phase 3 155030-63-0
49 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1,Not Applicable
50 Hormones Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
2 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
3 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
4 Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission Unknown status NCT00382109 Phase 3 thiotepa;cyclophosphamide;tacrolimus;methotrexate;sirolimus
5 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
6 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00103285 Phase 3 doxorubicin hydrochloride;cytarabine;dexamethasone;pegaspargase;methotrexate;leucovorin calcium;mercaptopurine;cyclophosphamide;thioguanine;vincristine sulfate
7 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005603 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
8 Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Completed NCT00005585 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;thioguanine;vincristine sulfate
9 Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia Completed NCT00381680 Phase 3 vincristine sulfate;prednisone;doxorubicin hydrochloride;pegaspargase;cytarabine;methotrexate;dexamethasone;etoposide;cyclophosphamide;leucovorin calcium;asparaginase;mercaptopurine
10 Dexamethasone Compared With Prednisone During Induction Therapy and MTX With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia Completed NCT00075725 Phase 3 cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;pegaspargase;prednisone;thioguanine;vincristine sulfate
11 Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia Completed NCT00430118 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
12 Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Completed NCT00720109 Phase 2, Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Methylprednisolone;Pegaspargase;Prednisone;Vincristine Sulfate
13 Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia Completed NCT00005977 Phase 3 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;methotrexate;vincristine sulfate
14 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Active, not recruiting NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
15 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Active, not recruiting NCT01190930 Phase 3 Cyclophosphamide;Cytarabine;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Thioguanine;Vincristine Sulfate
16 Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia Completed NCT00003671 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;leucovorin calcium;mercaptopurine;methotrexate;thioguanine;vincristine sulfate
17 Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia Completed NCT00002704 Phase 2 asparaginase;cyclophosphamide;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;liposomal cytarabine;mercaptopurine;mesna;methotrexate;therapeutic hydrocortisone;thiotepa;vincristine sulfate
18 Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia Completed NCT00003783 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;idarubicin;leucovorin calcium;mercaptopurine;methotrexate;prednisone;vincristine sulfate
19 Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Completed NCT00873093 Phase 2 L-asparaginase;doxorubicin hydrochloride;therapeutic hydrocortisone;vincristine sulfate;cytarabine;prednisone;bortezomib;pegaspargase;methotrexate;etoposide phosphate;cyclophosphamide;leucovorin calcium;High Dose MTX
20 Rituximab in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant for Relapsed or Refractory B-cell Lymphoma Completed NCT00867529 Phase 2
21 Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia Completed NCT00061945 Phase 1, Phase 2 allopurinol;cyclophosphamide;daunorubicin hydrochloride;vincristine sulfate;dexamethasone;asparaginase;imatinib mesylate;methotrexate;cytarabine;trimethoprim-sulfamethoxazole;mercaptopurine;leucovorin calcium;acyclovir
22 Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Completed NCT01093586 Phase 2 busulfan;cyclophosphamide;anti-thymocyte globulin;methylprednisolone;cyclosporine;mycophenolate mofetil
23 Biological Therapy in Treating Patients With Advanced Myelodysplastic Syndrome, Acute or Chronic Myeloid Leukemia, or Acute Lymphoblastic Leukemia Who Are Undergoing Stem Cell Transplantation Completed NCT00052520 Phase 1, Phase 2
24 Rituximab in Treating Young Patients Who Are Receiving Chemotherapy for B-Cell Non-Hodgkin's Lymphoma or B-Cell Acute Lymphoblastic Leukemia Completed NCT00324779 Phase 2
25 Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma Completed NCT00002471 Phase 2 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;leucovorin calcium;methotrexate;methylprednisolone;therapeutic hydrocortisone;thiotepa;vincristine sulfate
26 Monoclonal Antibody Therapy in Treating Patients With Lymphoma or Leukemia Completed NCT00003874 Phase 1, Phase 2
27 Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma Active, not recruiting NCT01700946 Phase 2 dexamethasone;vincristine sulfate;clofarabine;cyclophosphamide;etoposide;pegaspargase;methotrexate;mercaptopurine;cytarabine;mitoxantrone;teniposide;vinblastine;therapeutic hydrocortisone
28 Fludarabine Phosphate and Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Acute Lymphoblastic Leukemia or Chronic Myelogenous Leukemia That Has Responded to Treatment With Imatinib Mesylate, Dasatinib, or Nilotinib Active, not recruiting NCT00036738 Phase 2 Cyclosporine;Dasatinib;Fludarabine Phosphate;Imatinib Mesylate;Mycophenolate Mofetil;Nilotinib
29 Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement Suspended NCT02828358 Phase 2 Azacitidine;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisolone;Thioguanine;Vincristine Sulfate
30 Study in Pediatrics With Relapsed or Refractory Pediatric Acute Lymphoblastic Leukemia (pALL) or Lymphoblastic Lymphoma Terminated NCT02227108 Phase 2 Moxetumomab Pasudotox
31 Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia Terminated NCT00058461 Phase 2 ifosfamide;etoposide;carboplatin;methotrexate;cytarabine
32 Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma Completed NCT01403415 Phase 1 Dexamethasone;Methotrexate;Mitoxantrone Hydrochloride;Pegaspargase;Temsirolimus;Vincristine Sulfate
33 Combination Chemotherapy in Treating Children With Stage III or Stage IV Non-Hodgkin's Lymphoma or Acute Lymphoblastic Leukemia Completed NCT00003217 Phase 1 cyclophosphamide;cytarabine;dexamethasone;doxorubicin hydrochloride;methotrexate;vincristine sulfate
34 DT2219ARL for Relapsed or Refractory CD19 (+), CD 22 (+) B-Lineage Leukemia Or Lymphoma Completed NCT00889408 Phase 1
35 Cellular Adoptive Immunotherapy in Treating Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndromes That Relapsed After Donor Stem Cell Transplant Completed NCT00107354 Phase 1 cytarabine;etoposide;mitoxantrone hydrochloride
36 Chemotherapy, Radiation Therapy, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer Completed NCT00005092 Phase 1 Cyclophosphamide;Psoralen;Thiotepa
37 Ixabepilone in Treating Young Patients With Solid Tumors or Leukemia That Haven't Responded to Therapy Completed NCT00030108 Phase 1 ixabepilone
38 Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma Terminated NCT00101205 Phase 1 oxaliplatin;etoposide
39 Studying Genes in Samples From Younger Patients With Acute Lymphoblastic Leukemia Unknown status NCT01653613
40 Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00343369 Not Applicable asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;teniposide;thioguanine;vincristine sulfate
41 Potential Role of CD9 and Implication of Motility Process in Pathogenesis of TEL/ALM1-positive ALL Relapses (LAL TEL/ALM1 and CD9). Unknown status NCT01282593 Not Applicable
42 Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia Completed NCT01625143
43 Studying Biomarkers as a Diagnostic Tool in Samples From Younger Patients With B-Cell Acute Lymphoblastic Leukemia Completed NCT01540578
44 Genetic Test in Detecting Minimal Residual Disease in Samples From Younger Patients Registered on the COG-AALL08B1 Trial Completed NCT01629745
45 Studying Dexamethasone and Prednisone Sensitivity in Samples From Younger Patients With High-Risk B-Cell Precursor Acute Lymphoblastic Leukemia Completed NCT01553162
46 Laboratory Study of Lymphoblasts in Young Patients With High-Risk Acute Lymphoblastic Leukemia Completed NCT00896766
47 Biomarkers to Classify Young Patients With Acute Lymphoblastic Leukemia (ALL) and Remission Induction Therapy in Young Patients With B-Precursor ALL Completed NCT01225874 Not Applicable SC-PEG E. coli L-asparaginase;cytarabine;daunorubicin hydrochloride;dexamethasone;methotrexate;pegaspargase;prednisone;vincristine sulfate
48 Response or Resistance to Chemotherapy in Young Patients With Acute Lymphoblastic Leukemia Treated With Methotrexate Completed NCT00898404
49 Genetic Test To Identify Previously Undetectable Minimal Residual Disease in Cell Samples From Younger Patients With Acute Lymphoblastic Leukemia Completed NCT01533168
50 Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011) Completed NCT00866307 Not Applicable pegaspargase;cytarabine;vincristine sulfate;doxorubicin hydrochloride;cyclophosphamide;prednisone;dexamethasone;methotrexate;daunorubicin hydrochloride;mercaptopurine;thioguanine

Search NIH Clinical Center for B-Cell Childhood Acute Lymphoblastic Leukemia

Genetic Tests for B-Cell Childhood Acute Lymphoblastic Leukemia

Anatomical Context for B-Cell Childhood Acute Lymphoblastic Leukemia

MalaCards organs/tissues related to B-Cell Childhood Acute Lymphoblastic Leukemia:

42
B Cells, Myeloid, Bone, Testes, Brain, Liver, Bone Marrow

Publications for B-Cell Childhood Acute Lymphoblastic Leukemia

Articles related to B-Cell Childhood Acute Lymphoblastic Leukemia:

# Title Authors Year
1
Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. ( 30664635 )
2019
2
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia. ( 29632299 )
2018

Variations for B-Cell Childhood Acute Lymphoblastic Leukemia

Expression for B-Cell Childhood Acute Lymphoblastic Leukemia

Search GEO for disease gene expression data for B-Cell Childhood Acute Lymphoblastic Leukemia.

Pathways for B-Cell Childhood Acute Lymphoblastic Leukemia

Pathways related to B-Cell Childhood Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.07 CEBPE ETV6 RUNX1
2 11.06 IKZF1 RUNX1
3 10.64 IKZF1 RUNX1

GO Terms for B-Cell Childhood Acute Lymphoblastic Leukemia

Biological processes related to B-Cell Childhood Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.26 CEBPE ETV6 IKZF1 RUNX1
2 hematopoietic stem cell proliferation GO:0071425 8.62 ETV6 RUNX1

Molecular functions related to B-Cell Childhood Acute Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.56 CEBPE ETV6 IKZF1 RUNX1
2 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.4 ETV6 RUNX1
3 protein domain specific binding GO:0019904 9.37 ETV6 IKZF1
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.33 CEBPE ETV6 RUNX1
5 transcription regulatory region DNA binding GO:0044212 9.32 IKZF1 RUNX1
6 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.26 CEBPE ETV6 IKZF1 RUNX1
7 DNA-binding transcription factor activity GO:0003700 8.92 CEBPE ETV6 IKZF1 RUNX1

Sources for B-Cell Childhood Acute Lymphoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
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58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
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75 UMLS via Orphanet
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