MCID: BCL002
MIFTS: 43

B Cell Deficiency

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for B Cell Deficiency

MalaCards integrated aliases for B Cell Deficiency:

Name: B Cell Deficiency 12 15
Immunoglobulin Heavy Chain Deficiency 12 58 71
Immunoglobulin Heavy Chain Deletion 12
B Cell Deficiencies 12
Humoral Immune Defect 71

Classifications:

Orphanet: 58  
Rare immunological diseases


External Ids:

Disease Ontology 12 DOID:2115
ICD9CM 34 279.03
ICD10 via Orphanet 33 D80.8
UMLS via Orphanet 72 C0398692
Orphanet 58 ORPHA169110
UMLS 71 C0154276 C0398692 C0522274

Summaries for B Cell Deficiency

Disease Ontology : 12 A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly.

MalaCards based summary : B Cell Deficiency, also known as immunoglobulin heavy chain deficiency, is related to agammaglobulinemia and selective immunoglobulin deficiency disease. An important gene associated with B Cell Deficiency is IGLL1 (Immunoglobulin Lambda Like Polypeptide 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Fludarabine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hematopoietic system and cellular

Wikipedia : 74 Humoral immune deficiencies are conditions which cause impairment of humoral immunity, which can lead to... more...

Related Diseases for B Cell Deficiency

Diseases related to B Cell Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 409, show less)
# Related Disease Score Top Affiliating Genes
1 agammaglobulinemia 32.6 TEC IGLL1 ICOSLG CR2 CD40LG CD19
2 selective immunoglobulin deficiency disease 32.3 TNFRSF13B SH2D1A ICOSLG CD8A CD40LG
3 immunoglobulin alpha deficiency 31.3 TNFRSF13C TNFRSF13B ICOSLG CD8A CD40LG CD4
4 keratitis, hereditary 30.7 CD8A CD4 CCR6
5 agammaglobulinemia, x-linked 30.7 TEC SH2D1A ICOSLG CD40LG BTK
6 neuroretinitis 30.6 CD40LG CD4
7 severe combined immunodeficiency 30.5 IRF4 ICOSLG CD4 CD27 CD19 CCR6
8 autoimmune disease 30.5 TNFRSF13C TNFRSF13B ICOSLG CR2 CD40LG CCR6
9 giardiasis 30.3 CD8A CD40LG CD4
10 cryptococcosis 30.3 CD8A CD4 CCR6
11 nervous system disease 30.2 RNU4ATAC IRF4 ICOSLG CD4 CCR6
12 lymphopenia 30.2 IKZF1 ICOSLG CCR6 BTK
13 pneumocystosis 30.2 CD8A CD40LG CD4 CCR6
14 combined t cell and b cell immunodeficiency 30.1 IRF4 ICOSLG CD8A CD40LG CD4 CD19
15 acquired immunodeficiency syndrome 30.1 CR2 CD40LG CD4 CCR6
16 systemic scleroderma 30.0 ICOSLG CD8A CD40LG CD4 CCR6
17 t cell deficiency 30.0 CD8A CD40LG CD4 CD27 CCR6
18 bacterial infectious disease 29.9 ICOSLG CD8A CD40LG CD4 CCR6 BTK
19 diabetes mellitus, insulin-dependent 29.9 ICOSLG CD8A CD40LG CD4 CCR6
20 multiple sclerosis 29.8 TNFRSF13C CD8A CD40LG CD4 CD27 CCR6
21 pancytopenia 29.7 SH2D1A IRF4 IKZF1 CD8A CD40LG CD4
22 autoimmune lymphoproliferative syndrome 29.6 SH2D1A PRKCD ICOSLG CD8A CD40LG CD4
23 common variable immunodeficiency 29.4 TNFRSF13C TNFRSF13B SH2D1A PRKCD NFKB2 IRF4
24 immune deficiency disease 28.9 TNFRSF13B TEC SH2D1A IRF4 ICOSLG CR2
25 autoimmune lymphoproliferative syndrome, type iii 11.4
26 lambda 5 deficiency 11.1
27 immunoglobulin beta deficiency 11.1
28 primary agammaglobulinemia 10.7 TNFRSF13C TNFRSF13B
29 mu chain disease 10.7 IGLL1 CD40LG
30 riedel's fibrosing thyroiditis 10.7 CD40LG CD4
31 monoclonal paraproteinemia 10.6 CD40LG CD19
32 waldenstroem's macroglobulinemia 10.6 CD40LG CD19 BTK
33 ventilation pneumonitis 10.6 CD8A CD4
34 diffuse infiltrative lymphocytosis syndrome 10.6 CD8A CD4
35 latent syphilis 10.6 CD40LG CD4
36 gastroduodenitis 10.6 CD40LG CD4
37 autoimmune lymphoproliferative syndrome, type iia 10.6 CD8A CD4
38 primary syphilis 10.6 CD40LG CD4
39 mikulicz disease 10.6 ICOSLG CD4 CCR6
40 bird fancier's lung 10.6 IGLL1 CD8A CD4
41 asymptomatic neurosyphilis 10.6 CD40LG CD4
42 cll/sll 10.6 CD19 CCR6 BTK
43 chancroid 10.6 CD40LG CD4 CCR6
44 chromosome 14q11-q22 deletion syndrome 10.6 CD8A CD4
45 isolated growth hormone deficiency type iii 10.6 CD40LG BTK
46 adult acute lymphocytic leukemia 10.6 CD8A CD4 CCR6
47 diabetes mellitus, insulin-dependent, 23 10.6 CD8A CD4
48 autoimmune neuropathy 10.6 ICOSLG CD40LG CD4
49 tertiary neurosyphilis 10.6 CD40LG CD4
50 chronic conjunctivitis 10.6 ICOSLG CD4 CCR6
51 hemangioma of spleen 10.6 CR2 CD8A
52 scleral disease 10.6 CD40LG CD4 CCR6
53 immunodeficiency with hyper-igm, type 1 10.6 CD40LG BTK AICDA
54 iritis 10.6 CD40LG CD4 CCR6
55 autoimmune disease of peripheral nervous system 10.6 ICOSLG CD40LG CD4
56 cork-handlers' disease 10.6 CD8A CD40LG CD4
57 transient arthritis 10.6 CD40LG CD4
58 cerebral lymphoma 10.6 CD40LG CD4 CD19
59 nut allergy 10.6 ICOSLG CD4 CCR6
60 amebiasis 10.6 IGLL1 CD40LG CD4
61 syphilitic meningitis 10.6 CD8A CD40LG CD4
62 igg4-related disease 10.6 ICOSLG CD4 CCR6
63 meningovascular neurosyphilis 10.6 CD40LG CD4
64 spongiotic dermatitis 10.6 CD8A CD4 CCR6
65 coccidioidomycosis 10.6 CD40LG CD4 CCR6
66 lobomycosis 10.6 CR2 CD19
67 early yaws 10.6 CD8A CD40LG CD4
68 congenital hypogammaglobulinemia 10.6 IGLL1 CD40LG CD19 BTK
69 norwegian scabies 10.6 CD8A CD40LG CD4
70 suppurative lymphadenitis 10.6 CD4 CCR6
71 tertiary syphilis 10.6 CD8A CD40LG CD4
72 ebola hemorrhagic fever 10.6 ICOSLG CD8A CD40LG
73 acute retinal necrosis syndrome 10.6 CD8A CD40LG CD4
74 granulomatous hepatitis 10.6 CD8A CD40LG CD4
75 immune-complex glomerulonephritis 10.6 ICOSLG CD40LG CD4
76 iga glomerulonephritis 10.6 ICOSLG CD40LG CCR6
77 esophageal candidiasis 10.6 CD8A CD4 CCR6
78 west nile encephalitis 10.6 CD8A CD40LG CD4
79 keratoconjunctivitis sicca 10.6 CD40LG CD4 CCR6
80 cerebritis 10.6 CD8A CD40LG CD4
81 pneumonic tularemia 10.6 CD8A CD4 CCR6
82 parotid disease 10.6 CD8A CD40LG CD4
83 parapsoriasis 10.6 CD8A CD4
84 secondary syphilis 10.6 CD8A CD40LG CD4
85 optic papillitis 10.6 CD40LG CD4
86 lymphocytic leukemia 10.6 IKZF1 CD40LG CCR6 BTK
87 splenic marginal zone lymphoma 10.6 NFKB2 BTK AICDA
88 tularemia 10.6 CD8A CD40LG CD4
89 immunodeficiency with hyper-igm, type 5 10.6 TNFRSF13B CD40LG AICDA
90 central nervous system hematologic cancer 10.6 IRF4 CD4 CD19
91 uveoparotid fever 10.6 CD8A CD40LG CD4
92 blood protein disease 10.6 ICOSLG CD40LG CD19
93 duodenitis 10.6 CD8A CD40LG CD4
94 monkeypox 10.6 CD8A CD40LG CD4
95 polyclonal hypergammaglobulinemia 10.6 CD8A CD40LG CD4
96 hairy tongue 10.6 CD8A CD40LG CD4
97 xerophthalmia 10.6 CD8A CD40LG CD4
98 common cold 10.6 ICOSLG CD4 CCR6
99 dysentery 10.6 CD40LG CD4 CCR6
100 miliary tuberculosis 10.6 CD8A CD40LG CD4
101 capillary leak syndrome 10.6 ICOSLG CD8A CD19
102 chorioretinitis 10.5 CD8A CD40LG CD4
103 fungal meningitis 10.5 CD8A CD40LG CD4
104 taeniasis 10.5 CD8A CD40LG CD4
105 immunoglobulin a deficiency 1 10.5 TNFRSF13B ICOSLG CD40LG BTK
106 orchitis 10.5 CD8A CD40LG CD4
107 hantavirus hemorrhagic fever with renal syndrome 10.5 CD8A CD40LG CD4
108 facial paralysis 10.5 CD8A CD40LG CD4
109 congenital toxoplasmosis 10.5 CD8A CD40LG CD4
110 immunodeficiency 19 10.5 SH2D1A CD8A CD4
111 blepharitis 10.5 CD8A CD4 CCR6
112 viral exanthem 10.5 CD40LG CD4
113 acute cystitis 10.5 CD40LG CD4 CCR6
114 facial nerve disease 10.5 CD8A CD40LG CD4
115 mast cell neoplasm 10.5 ICOSLG CD8A CD4
116 bronchopneumonia 10.5 CD8A CD40LG CD4
117 fallopian tube disease 10.5 CD8A CD40LG CD4
118 lymphoproliferative syndrome 10.5 SH2D1A PRKCD ICOSLG CD27
119 genital herpes 10.5 CD8A CD4 CCR6
120 brachydactyly, type c 10.5 CD8A CD4 CCR6
121 streptococcus pneumonia 10.5 CD8A CD40LG CD4
122 cryptosporidiosis 10.5 CD8A CD40LG CD4
123 nail disease 10.5 CD8A CD4 CCR6
124 ehrlichiosis 10.5 CD8A CD40LG CD4
125 metal allergy 10.5 CD8A CD4
126 vaginal disease 10.5 CD8A CD4 CCR6
127 gastrointestinal tuberculosis 10.5 CD40LG CD4
128 anus disease 10.5 CD8A CD4 CCR6
129 variola major 10.5 CD8A CD4
130 pericardium disease 10.5 CD8A CD40LG CD4
131 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 10.5 SH2D1A CD8A CD27
132 oral candidiasis 10.5 CD8A CD4 CCR6
133 lymphadenitis 10.5 ICOSLG CD4 CCR6
134 follicular mucinosis 10.5 CD8A CD4
135 acute proliferative glomerulonephritis 10.5 ICOSLG CD40LG CD4 CCR6
136 b-cell adult acute lymphocytic leukemia 10.5 IKZF1 CD19
137 pharyngitis 10.5 CD8A CD40LG CD4
138 relapsed/refractory diffuse large b-cell lymphoma 10.5 IRF4 CD19
139 lymphoplasmacytic lymphoma 10.5 IRF4 CD40LG CD19 BTK
140 autoimmune disease of skin and connective tissue 10.5 ICOSLG CD40LG CD4 CCR6
141 yellow fever 10.5 CD8A CD40LG CCR6
142 bullous skin disease 10.5 ICOSLG CD40LG CD4 CCR6
143 nickel allergic contact dermatitis 10.5 CD8A CD4
144 spondyloarthropathy 1 10.5 ICOSLG CD40LG CCR6
145 transient hypogammaglobulinemia 10.5 RNU4ATAC CD40LG CD19 BTK
146 dysgammaglobulinemia 10.5 TNFRSF13B SH2D1A ICOSLG CD40LG
147 immunodeficiency, common variable, 2 10.5 TNFRSF13C TNFRSF13B CR2 CD19
148 myelitis 10.5 ICOSLG CD40LG CD27 CCR6
149 bare lymphocyte syndrome, type ii 10.5 CD8A CD40LG CD4
150 epidemic typhus 10.5 CD8A CD40LG CD4
151 cranial nerve disease 10.5 ICOSLG CD40LG CD4 CCR6
152 pleural disease 10.5 CD8A CD4 CCR6
153 hypotrichosis 10.5 ICOSLG CD8A CD4 CCR6
154 cryoglobulinemia 10.5 CR2 CD40LG CD27
155 autoimmune peripheral neuropathy 10.5 ICOSLG CD4
156 autoimmune disease of cardiovascular system 10.5 ICOSLG CD8A CD4 CCR6
157 epidermodysplasia verruciformis 1 10.5 CD8A CD4 CCR6
158 dacryoadenitis 10.5 ICOSLG CD8A CD4 CCR6
159 poliomyelitis 10.5 CD8A CD40LG CD4 BTK
160 combined thymoma 10.5 CD8A CD4
161 salmonellosis 10.5 CD8A CD4 CCR6
162 autoimmune glomerulonephritis 10.5 ICOSLG CD8A CD4 CCR6
163 autoimmune disease of eyes, ear, nose and throat 10.5 ICOSLG CD8A CD4 CCR6
164 immunodeficiency with hyper-igm, type 4 10.5 TNFRSF13C CD40LG CD27 AICDA
165 cryptococcal meningitis 10.5 TNFRSF13C TNFRSF13B CD8A CD4
166 dengue disease 10.5 ICOSLG CD8A CD40LG CCR6
167 neurosarcoidosis 10.5 CD8A CD4
168 sialadenitis 10.5 ICOSLG CD8A CD4 CCR6
169 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.5 ICOSLG CD8A CD4 CCR6
170 blastomycosis 10.5 CD8A CD40LG CD4 CCR6
171 t-cell adult acute lymphocytic leukemia 10.5 IRF4 CD8A CD4 CCR6
172 listeriosis 10.5 ICOSLG CD8A CD4 CCR6
173 central nervous system vasculitis 10.5 CD8A CD40LG CD4 CCR6
174 nasal cavity disease 10.5 ICOSLG CD8A CD4 CCR6
175 immunodeficiency with hyper-igm, type 2 10.5 TNFRSF13B ICOSLG CD40LG AICDA
176 primary systemic mycosis 10.5 CD8A CD40LG CD4 CCR6
177 respiratory allergy 10.5 ICOSLG CD8A CD4 CCR6
178 histoplasmosis 10.5 CD8A CD40LG CD4 CCR6
179 bile duct disease 10.5 ICOSLG CD40LG CD4 CCR6
180 panuveitis 10.5 CD8A CD40LG CD4 CCR6
181 herpangina 10.5 CD8A CD40LG CD4 CCR6
182 splenic disease 10.5 CD8A CD40LG CD4 CCR6
183 viral encephalitis 10.5 CD8A CD40LG CD4 CCR6
184 adult t-cell leukemia 10.5 IRF4 CD4 CCR6
185 rectal disease 10.5 CD8A CD40LG CD4 CCR6
186 granulomatosis with polyangiitis 10.5 ICOSLG CD40LG CD4 CCR6
187 adenoid hypertrophy 10.5 CD8A CD40LG CD4 CD19
188 severe cutaneous adverse reaction 10.5 IKZF1 CD8A CD40LG CD4
189 syphilis 10.5 CD8A CD40LG CD4 CCR6
190 herpes zoster 10.5 ICOSLG CD8A CD40LG CD4
191 optic nerve disease 10.5 ICOSLG CD40LG CD4 CCR6
192 meningoencephalitis 10.5 CD8A CD40LG CD4 CCR6
193 cd3zeta deficiency 10.5 CD8A CD4
194 vitiligo-associated multiple autoimmune disease susceptibility 1 10.5 ICOSLG CD8A CD4 CCR6
195 temporal arteritis 10.5 CD8A CD40LG CD4 CCR6
196 chediak-higashi syndrome 10.5 ICOSLG CD8A CD4 CCR6
197 lymphoma, hodgkin, classic 10.5 SH2D1A IRF4 ICOSLG CCR6
198 isolated growth hormone deficiency 10.5 RNU4ATAC BTK AICDA
199 testicular disease 10.5 CD8A CD40LG CD4 CCR6
200 agammaglobulinemia, non-bruton type 10.5 IGLL1 BTK
201 leprosy 3 10.5 CD8A CD40LG CD4 CCR6
202 lymphoid interstitial pneumonia 10.5 CD8A CD40LG CD4 CD19
203 immunodeficiency 18 10.5 CD8A CD4
204 lymphoproliferative syndrome 2 10.5 TNFRSF13B SH2D1A CD8A CD27
205 schuurs-hoeijmakers syndrome 10.5 CD40LG CD27 CD19 AICDA
206 corneal disease 10.4 CD8A CD4 CCR6
207 sezary's disease 10.4 CD8A CD4 CCR6
208 reticulum cell sarcoma 10.4 CR2 CD4
209 viral infectious disease 10.4 ICOSLG CD40LG CD4 CCR6
210 oral hairy leukoplakia 10.4 SH2D1A CR2 CD8A CD4
211 macroglobulinemia 10.4 TNFRSF13C TNFRSF13B CD40LG CD27 BTK
212 plasma protein metabolism disease 10.4 CD40LG CD4 CD19 CCR6 BTK
213 hemophagocytic lymphohistiocytosis 10.4 SH2D1A CR2 CD27
214 plasmacytoma 10.4 IRF4 CD27 AICDA
215 glucose metabolism disease 10.4 ICOSLG CD8A CD4 CCR6
216 mycobacterium tuberculosis 1 10.4 ICOSLG CD8A CD4 CCR6
217 autosomal recessive disease 10.4 RNU4ATAC IRF4 IGLL1 CCR6
218 thrombocytopenic purpura, autoimmune 10.4 ICOSLG CD40LG CD4 CD19 CCR6
219 monoclonal gammopathy of uncertain significance 10.4 ICOSLG CD40LG CD27 CD19 CCR6
220 respiratory system disease 10.4 IRF4 ICOSLG CD4 CCR6
221 mantle cell lymphoma 10.4 CD40LG CD19 BTK AICDA
222 childhood type dermatomyositis 10.4 ICOSLG CD8A CD40LG CD4 CCR6
223 lichen disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
224 plasma cell neoplasm 10.4 IRF4 ICOSLG CD8A CD40LG CD19
225 lacrimal apparatus disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
226 progressive multifocal leukoencephalopathy 10.4 ICOSLG CD8A CD40LG CD4 CCR6
227 conjunctival disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
228 coccidiosis 10.4 ICOSLG CD8A CD40LG CD4 CCR6
229 autoimmune disease of urogenital tract 10.4 ICOSLG CD8A CD40LG CD4 CCR6
230 thymus gland disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
231 autoimmune disease of endocrine system 10.4 ICOSLG CD8A CD40LG CD4 CCR6
232 thymus cancer 10.4 ICOSLG CD8A CD40LG CD4 CCR6
233 opportunistic mycosis 10.4 ICOSLG CD8A CD40LG CD4 CCR6
234 paranasal sinus disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
235 lymph node disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
236 cellulitis 10.4 ICOSLG CD8A CD40LG CD4 CCR6
237 neuromuscular junction disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
238 nose disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
239 salivary gland disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
240 autoimmune disease of gastrointestinal tract 10.4 ICOSLG CD8A CD40LG CD4 CCR6
241 extrinsic cardiomyopathy 10.4 ICOSLG CD8A CD40LG CD4 CCR6
242 commensal bacterial infectious disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
243 parasitic helminthiasis infectious disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
244 diffuse large b-cell lymphoma 10.4 IRF4 CD19 BTK AICDA
245 uveal disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
246 collagen disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
247 bacterial pneumonia 10.4 ICOSLG CD8A CD40LG CD4 CCR6
248 hair disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
249 marginal zone b-cell lymphoma 10.4 IRF4 CR2 CD40LG CD19 CCR6
250 anemia, autoimmune hemolytic 10.4 ICOSLG CD8A CD40LG CD4 CD19
251 parasitic protozoa infectious disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
252 pulmonary disease, chronic obstructive 10.4 ICOSLG CD8A CD4 CCR6
253 hypotrichosis 1 10.4 ICOSLG CD8A CD4 CD19 CCR6
254 bronchial disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
255 cholangitis, primary sclerosing 10.4 ICOSLG CD8A CD40LG CD4 CCR6
256 middle ear disease 10.4 CD8A CD40LG CD4 CD19 CCR6
257 connective tissue cancer 10.4 IRF4 ICOSLG CD8A CD4 CCR6
258 bone inflammation disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
259 skin disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
260 upper respiratory tract disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
261 congenital syphilis 10.4 CD40LG CD4
262 good syndrome 10.4 TNFRSF13B CD8A CD40LG CD4 CD19
263 demyelinating disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
264 peripheral nervous system disease 10.4 ICOSLG CD8A CD40LG CD4 CCR6
265 behcet syndrome 10.4 ICOSLG CD8A CD40LG CD4 CCR6
266 autosomal genetic disease 10.4 RNU4ATAC IRF4 ICOSLG CD4 CCR6
267 celiac disease 1 10.4 ICOSLG CD8A CD40LG CD4 CCR6
268 mononeuritis of upper limb and mononeuritis multiplex 10.4 CD40LG CD4
269 autosomal dominant non-syndromic intellectual disability 10.3 CD40LG CD27 CD19 AICDA
270 neuromuscular disease 10.3 ICOSLG CD8A CD40LG CD4 CCR6
271 human immunodeficiency virus infectious disease 10.3 ICOSLG CR2 CD8A CD4 CCR6
272 muscular disease 10.3 ICOSLG CD8A CD40LG CD4 CCR6
273 malignant ovarian surface epithelial-stromal neoplasm 10.3 ICOSLG CD8A CCR6
274 acute t cell leukemia 10.3 IKZF1 CD8A CD4
275 follicular lymphoma 10.3 TNFRSF13C IRF4 CR2 CD27 AICDA
276 leukemia, acute lymphoblastic 10.3 IRF4 IKZF1 CD19 CCR6 BTK
277 anti-basement membrane glomerulonephritis 10.3 CD4 CCR6
278 ovary epithelial cancer 10.3 ICOSLG CD8A CCR6
279 pulmonary fibrosis, idiopathic 10.3 ICOSLG CD8A CD4 CCR6
280 primary thrombocytopenia 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
281 autoimmune disease of blood 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
282 spinal cord disease 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
283 exanthem 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
284 hypersensitivity reaction type iv disease 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
285 blood coagulation disease 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
286 autoimmune disease of musculoskeletal system 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
287 autoimmune disease of central nervous system 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
288 blood platelet disease 10.3 ICOSLG CD8A CD40LG CD4 CD19 CCR6
289 sarcoidosis 1 10.3 ICOSLG CD8A CD40LG CD4 CD27 CCR6
290 immunodeficiency with hyper-igm, type 3 10.3 TNFRSF13B ICOSLG CD8A CD40LG CD4 AICDA
291 dermatitis, atopic 10.2 ICOSLG CD8A CD40LG CD4 CD19 CCR6
292 acute interstitial pneumonia 10.2 CD8A CD4
293 omenn syndrome 10.2 ICOSLG CD8A CD40LG CD4 CD19 AICDA
294 connective tissue disease 10.2 RNU4ATAC ICOSLG CD8A CD40LG CD4 CCR6
295 x-linked recessive disease 10.2 SH2D1A ICOSLG CD8A CD40LG CD4 CCR6
296 x-linked monogenic disease 10.2 SH2D1A ICOSLG CD8A CD40LG CD4 CCR6
297 burkitt lymphoma 10.2 SH2D1A IRF4 CR2 CD40LG CD19 AICDA
298 cat-scratch disease 10.2 CD40LG CD4
299 bone marrow cancer 10.2 IRF4 ICOSLG CD8A CD40LG CD4 CD19
300 leukocyte disease 10.2 IRF4 ICOSLG CD8A CD40LG CD4 CD19
301 immune system disease 10.2 IRF4 ICOSLG CD8A CD40LG CD4 CD19
302 thrombocytopenia due to platelet alloimmunization 10.2 TNFRSF13B ICOSLG CD8A CD40LG CD4 CD19
303 digeorge syndrome 10.2 CD8A CD40LG CD4 CD27
304 leukemia, acute myeloid 10.2 IKZF1 ICOSLG CD8A CD4 CD19 CCR6
305 chickenpox 10.2 ICOSLG CD8A CD40LG CD4 CD27 CD19
306 primary bacterial infectious disease 10.2 ICOSLG CD8A CD40LG CD4 CD27 CD19
307 cone-rod dystrophy 2 10.2 TNFRSF13C TNFRSF13B ICOSLG CD8A CD40LG CD4
308 transient hypogammaglobulinemia of infancy 10.1 TNFRSF13B RNU4ATAC CR2 CD40LG CD27 CD19
309 pfeiffer syndrome 10.1 SH2D1A CR2 CD8A CD40LG CD4 CD19
310 eye disease 10.1 RNU4ATAC IRF4 ICOSLG CD8A CD40LG CD4
311 b-cell lymphoma 10.1 TNFRSF13C NFKB2 IRF4 IKZF1 CR2 CD19
312 hematologic cancer 10.1 IRF4 IKZF1 ICOSLG CD8A CD40LG CD4
313 lymphatic system cancer 10.1 IRF4 ICOSLG CR2 CD8A CD40LG CD4
314 exanthema subitum 10.0 CD40LG CD4
315 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
316 chlamydia 10.0
317 allergic encephalomyelitis 10.0
318 lymphocytic choriomeningitis 10.0
319 lymphoma, mucosa-associated lymphoid type 10.0 TNFRSF13C NFKB2 IRF4 CR2 CD40LG CD4
320 splenomegaly 9.9
321 lymphatic system disease 9.9 SH2D1A IRF4 ICOSLG CR2 CD8A CD40LG
322 lymphoma 9.9 SH2D1A NFKB2 IRF4 CR2 CD40LG CD27
323 mature b-cell neoplasm 9.9 IRF4 ICOSLG CR2 CD8A CD40LG CD4
324 hashimoto thyroiditis 9.9
325 graft-versus-host disease 9.9
326 allergic hypersensitivity disease 9.9
327 contact dermatitis 9.9
328 allergic contact dermatitis 9.9
329 thyroiditis 9.9
330 herpes simplex 9.9
331 hypereosinophilic syndrome 9.9
332 chronic graft versus host disease 9.9
333 cd40 ligand deficiency 9.9 TNFRSF13C TNFRSF13B SH2D1A ICOSLG CD40LG CD4
334 myasthenia gravis 9.8
335 cerebral artery occlusion 9.8
336 chagas disease 9.8
337 dermatitis 9.8
338 ischemia 9.8
339 central nervous system disease 9.8
340 retinitis 9.8
341 pneumonia 9.8
342 diabetes mellitus 9.8
343 systemic lupus erythematosus 9.7 TNFRSF13C TNFRSF13B IRF4 ICOSLG CR2 CD8A
344 atrial standstill 1 9.6
345 yellow nail syndrome 9.6
346 schistosoma mansoni infection, susceptibility/ 9.6
347 tl antigen 9.6
348 triiodothyronine receptor auxiliary protein 9.6
349 volvulus of midgut 9.6
350 proteasome-associated autoinflammatory syndrome 1 9.6
351 retinitis pigmentosa 9.6
352 yemenite deaf-blind hypopigmentation syndrome 9.6
353 aplastic anemia 9.6
354 west nile virus 9.6
355 chromosome 16p13.3 deletion syndrome, proximal 9.6
356 agammaglobulinemia 2, autosomal recessive 9.6
357 agammaglobulinemia 3, autosomal recessive 9.6
358 muscle hypertrophy 9.6
359 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.6
360 immunodeficiency, common variable, 10 9.6
361 sideroblastic anemia with b-cell immunodeficiency, periodic fevers, and developmental delay 9.6
362 herpes simplex virus keratitis 9.6
363 trypanosomiasis 9.6
364 osteomyelitis 9.6
365 glucose intolerance 9.6
366 filariasis 9.6
367 brucellosis 9.6
368 pertussis 9.6
369 disseminated intravascular coagulation 9.6
370 microcytic anemia 9.6
371 diphtheria 9.6
372 onchocerciasis 9.6
373 acute leukemia 9.6
374 paracoccidioidomycosis 9.6
375 diarrhea 9.6
376 typhoid fever 9.6
377 biliary atresia 9.6
378 schistosomiasis 9.6
379 cholera 9.6
380 arteriosclerosis 9.6
381 bilirubin metabolic disorder 9.6
382 endometriosis 9.6
383 glomerulonephritis 9.6
384 pulmonary tuberculosis 9.6
385 acute kidney failure 9.6
386 chronic granulomatous disease 9.6
387 vaccinia 9.6
388 hyperglycemia 9.6
389 scrapie 9.6
390 eosinophilic pneumonia 9.6
391 t-cell leukemia 9.6
392 cataract 9.6
393 sideroblastic anemia 9.6
394 allergic asthma 9.6
395 pulmonary eosinophilia 9.6
396 encephalitis 9.6
397 stomatitis 9.6
398 pulmonary emphysema 9.6
399 alopecia 9.6
400 toxoplasmosis 9.6
401 specific antibody deficiency 9.6
402 trnt1 deficiency 9.6
403 encephalopathy 9.6
404 mucopolysaccharidoses 9.6
405 rapidly involuting congenital hemangioma 9.6
406 isolated agammaglobulinemia 9.6
407 myeloma, multiple 9.6 TNFRSF13C TNFRSF13B NFKB2 IRF4 IKZF1 ICOSLG
408 leukemia, chronic lymphocytic 9.5 TNFRSF13C TNFRSF13B IRF4 ICOSLG CR2 CD8A
409 lymphoma, non-hodgkin, familial 9.3 TNFRSF13C TNFRSF13B SH2D1A IRF4 IKZF1 ICOSLG

Graphical network of the top 20 diseases related to B Cell Deficiency:



Diseases related to B Cell Deficiency

Symptoms & Phenotypes for B Cell Deficiency

MGI Mouse Phenotypes related to B Cell Deficiency:

45 (showing 4, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.09 AICDA BTK CCR6 CD19 CD27 CD4
2 cellular MP:0005384 10 AICDA BTK CD19 CD27 CD4 CD40LG
3 homeostasis/metabolism MP:0005376 9.8 AICDA BTK CCR6 CD19 CD4 CD40LG
4 immune system MP:0005387 9.55 AICDA BTK CCR6 CD19 CD27 CD4

Drugs & Therapeutics for B Cell Deficiency

Drugs for B Cell Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 8, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
2
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
3 Interleukin-2 Phase 1
4 Alkylating Agents Phase 1
5 Antirheumatic Agents Phase 1
6 Immunosuppressive Agents Phase 1
7 Antimetabolites Phase 1
8 Immunologic Factors Phase 1

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 A Phase I Study of Adoptive Transfer of Autologous Tumour Antigen-Specific T Cells With Pre-conditioning Chemotherapy and Intravenous IL2 in Patients With CD19 Positive Malignancy Unknown status NCT01493453 Phase 1

Search NIH Clinical Center for B Cell Deficiency

Genetic Tests for B Cell Deficiency

Anatomical Context for B Cell Deficiency

MalaCards organs/tissues related to B Cell Deficiency:

40
B Cells, T Cells, Bone, Bone Marrow, Thyroid, Skin, Lung

Publications for B Cell Deficiency

Articles related to B Cell Deficiency:

(showing 219, show less)
# Title Authors PMID Year
1
Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart. 61
31945014 2020
2
Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice. 61
31665632 2019
3
Early B cell developmental impairment with progressive B cell deficiency in NFKB2 mutated CVID disease without autoimmunity. 61
30500415 2019
4
B1 cells protect against Schistosoma japonicum-induced liver inflammation and fibrosis by controlling monocyte infiltration. 61
31194740 2019
5
Atypical SIFD with novel TRNT1 mutations: a case study on the pathogenesis of B-cell deficiency. 61
30758723 2019
6
B-Cell Deficiency Lowers Blood Pressure in Mice. 61
30636551 2019
7
Inhibition of B cell-dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation. 61
30728330 2019
8
Enteroviral Encephalitis in a Child With CNS Relapse of Burkitt Leukemia Treated With Rituximab. 61
29315142 2019
9
Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy. 61
31708923 2019
10
A Novel CD3G Mutation in a Taiwanese Patient With Normal T Regulatory Function Presenting With the CVID Phenotype Free of Autoimmunity-Analysis of all Genotypes and Phenotypes. 61
31921117 2019
11
Evans Syndrome in Childhood: Long Term Follow-Up and the Evolution in Primary Immunodeficiency or Rheumatological Disease. 61
31396497 2019
12
B Cell and CD4 T Cell Interactions Promote Development of Atherosclerosis. 61
31998318 2019
13
Gain-of-function IKBKB mutation causes human combined immune deficiency. 61
30337470 2018
14
Phospholipid flippases enable precursor B cells to flee engulfment by macrophages. 61
30355768 2018
15
Initiation of LPS-induced pulmonary dysfunction and its recovery occur independent of T cells. 61
30466430 2018
16
Restoration of regulatory B cell deficiency following alemtuzumab therapy in patients with relapsing multiple sclerosis. 61
30373595 2018
17
Altered gastrointestinal motility involving autoantibodies in the experimental autoimmune encephalomyelitis model of multiple sclerosis. 61
29644797 2018
18
Embolizing pulmonary aspergillosis, mycobacterial & aspergillous splenic abscess and cytomegalovirus co-infection following steroid induced immunosuppression: a case report. 61
30081818 2018
19
The Ikaros family in lymphocyte development. 61
29278858 2018
20
Inherited Immunodeficiency: A New Association With Early-Onset Childhood Panniculitis. 61
29610179 2018
21
MECOM-associated syndrome: a heterogeneous inherited bone marrow failure syndrome with amegakaryocytic thrombocytopenia. 61
29540340 2018
22
Complete B Cell Deficiency Reduces Allograft Inflammation and Intragraft Macrophages in a Rat Kidney Transplant Model. 61
29215459 2018
23
B-cell Deficiency: A De Novo IKZF1 Patient and Review of the Literature. 61
29461212 2018
24
B cell subset distribution is altered in patients with severe periodontitis. 61
29447240 2018
25
Humoral Immune Reconstitution Kinetics after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Maturation Block of IgM Memory B Cells May Lead to Impaired Antibody Immune Reconstitution. 61
28495643 2017
26
Comprehensive validation of T- and B-cell deficiency in rag1-null zebrafish: Implication for the robust innate defense mechanisms of teleosts. 61
28790360 2017
27
Clinical, immunologic, molecular analyses and outcomes of iranian patients with LRBA deficiency: A longitudinal study. 61
28512785 2017
28
Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations. 61
27939403 2017
29
Human IκBα Gain of Function: a Severe and Syndromic Immunodeficiency. 61
28597146 2017
30
Hematopoietic Stem Cell Transplant for Primary Immunodeficiency Diseases: A Single-Center Experience. 61
27001505 2017
31
The mast cell-B cell axis in lung vascular remodeling and pulmonary hypertension. 61
28235950 2017
32
The Impact of IL-17 in Atherosclerosis. 61
28425862 2017
33
Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor. 61
27918564 2017
34
Antigen presentation by B cells guides programing of memory CD4+ T-cell responses to a TLR4-agonist containing vaccine in mice. 61
27701733 2016
35
Progressive severe B cell deficiency in pediatric Rubinstein-Taybi syndrome. 61
27825976 2016
36
Common variable immunodeficiency, impaired neurological development and reduced numbers of T regulatory cells in a 10-year-old boy with a STAT1 gain-of-function mutation. 61
27063510 2016
37
Mutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity. 61
27303042 2016
38
Regulatory T and B lymphocytes in a spontaneous autoimmune polyneuropathy. 61
26671281 2016
39
Infancy-Onset T1DM, Short Stature, and Severe Immunodysregulation in Two Siblings With a Homozygous LRBA Mutation. 61
26745254 2016
40
Spectrum of Phenotypes Associated with Mutations in LRBA. 61
26707784 2016
41
Differentially correlated genes in co-expression networks control phenotype transitions. 61
28163897 2016
42
Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage. 61
27066009 2016
43
Impaired toll-like receptor signalling in peripheral B cells from newly diagnosed type-2 diabetic subjects. 61
25959254 2015
44
Cell extrinsic alterations in splenic B cell maturation in Flt3-ligand knockout mice. 61
26029370 2015
45
Additional B-cell deficiency does not affect growth and angiogenesis of ectopic human endometrium in T-cell-deficient endometriosis mouse models during long-term culture. 61
25270508 2014
46
Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. 61
25237204 2014
47
NK and B cell deficiency in a MPS type II family with novel mutation in the IDS gene. 61
25038527 2014
48
Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT. 61
24833353 2014
49
Multiple potential roles for B cells in atherosclerosis. 61
24813455 2014
50
Leukocyte β7 integrin targeted by Krüppel-like factors. 61
25015818 2014
51
Human lymphoid development in the absence of common γ-chain receptor signaling. 61
24771849 2014
52
Respiratory infection and primary immune deficiency - what does the general physician need to know? 61
24999779 2014
53
A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27⁻IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation. 61
24211716 2013
54
Differential regulation of hepatic organic cation transporter 1, organic anion-transporting polypeptide 1a4, bile-salt export pump, and multidrug resistance-associated protein 2 transporter expression in lymphocyte-deficient mice associates with interleukin-6 production. 61
23929842 2013
55
Inhibitors of BTK and ITK: state of the new drugs for cancer, autoimmunity and inflammatory diseases. 61
23672610 2013
56
Effect of immunodeficiency on MPV shedding and transmission. 61
23849445 2013
57
Pharmacologic inhibition of IκB kinase activates immediate hypersensitivity reactions in mice. 61
23665348 2013
58
A case of IgM deficiency with B cell deficiency detected by ABO discrepancy in a patient with acute osteomyelitis. 61
23667850 2013
59
Purine nucleoside phosphorylase deficiency presenting as severe combined immune deficiency. 61
23371835 2013
60
Comprehensive report of primary immunodeficiency disorders from a tertiary care center in India. 61
23108471 2013
61
B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ. 61
23319571 2013
62
Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27. 61
22801960 2013
63
Novel spontaneous deletion of artemis exons 10 and 11 in mice leads to T- and B-cell deficiency. 61
24069355 2013
64
Increased infection rate after preemptive rituximab treatment for Epstein-Barr virus reactivation after allogeneic hematopoietic stem-cell transplantation. 61
23001354 2012
65
Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax. 61
22472773 2012
66
Characteristics and influencing factors of CD19+ B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation. 61
22674381 2012
67
A novel IL-10-independent regulatory role for B cells in suppressing autoimmunity by maintenance of regulatory T cells via GITR ligand. 61
22368274 2012
68
T and B cell deficiency associated with yellow nail syndrome. 61
21995335 2012
69
Ileal Peyer's patches are not necessary for systemic B cell development and maintenance and do not contribute significantly to the overall B cell pool in swine. 61
22013120 2011
70
Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. 61
21875957 2011
71
Chronic B cell deficiency from birth prevents age-related alterations in the B lineage. 61
21810615 2011
72
More on NK-cell and B-cell deficiency with a thymic mass. 61
21591963 2011
73
ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. 61
21423173 2011
74
NK-cell and B-cell deficiency with a thymic mass. 61
21306273 2011
75
Hoffman syndrome: New patients, new insights. 61
21204224 2011
76
[Subcutaneous immunoglobulin substitution and therapy]. 61
21177233 2011
77
Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression. 61
20870947 2010
78
Mature B cells are critical to T-cell-mediated tumor immunity induced by an agonist anti-GITR monoclonal antibody. 61
20842058 2010
79
Macrophage polarization to a unique phenotype driven by B cells. 61
20468007 2010
80
The adaptor protein Sh2d3c is critical for marginal zone B cell development and function. 61
20505138 2010
81
Foxo1 regulates marginal zone B-cell development. 61
20449867 2010
82
Long-term immune deficiency after allogeneic stem cell transplantation: B-cell deficiency is associated with late infections. 61
20133894 2010
83
Enteroviral encephalitis in a patient with a marginal zone lymphomatreated with rituximab. 61
20508271 2010
84
B cells delay neutrophil migration toward the site of stimulus: tardiness critical for effective bacillus Calmette-Guérin vaccination against tuberculosis infection in mice. 61
20028653 2010
85
SH2-dependent autophosphorylation within the Tec family kinase Itk. 61
19523959 2009
86
Contribution of B cells and antibody to cardiac allograft vasculopathy. 61
19696629 2009
87
Allogeneic hematopoietic stem cell transplantation recipients have defects of both switched and igm memory B cells. 61
19539210 2009
88
Delay in B-lymphocyte recovery and function following rituximab for EBV-associated lymphoproliferative disease early post-allogeneic hematopoietic SCT. 61
19029962 2009
89
Immunoglobulin class switch recombination: study through human natural mutants. 61
19008192 2009
90
[X-linked Bruton congenital agammaglobulinemia. Case report]. 61
21495305 2009
91
XLA-associated neutropenia treatment: a case report and review of the literature. 61
18799945 2008
92
Agammaglobulinemia and Staphylococcus aureus botryomycosis in a cohort of related sentinel Swiss Webster mice. 61
18322060 2008
93
B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes. 61
18184927 2008
94
West Nile 25A virus infection of B-cell-deficient ((micro)MT) mice: characterization of neuroinvasiveness and pseudoreversion of the viral envelope protein. 61
18272752 2008
95
Systemic autoimmunity in BAFF-R-mutant A/WySnJ strain mice. 61
18200501 2008
96
Molecular genetic analysis of Hungarian patients with the hyper-immunoglobulin M syndrome. 61
17553565 2008
97
Clinical and immunologic features of pediatric patients with common variable immunodeficiency and respiratory complications. 61
18714533 2008
98
Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. 61
17767948 2008
99
B lymphocyte deficiency in IgH-transgenic rabbits. 61
17628859 2007
100
A progressive, fatal dystonia-Parkinsonism syndrome in a patient with primary immunodeficiency receiving chronic IVIG therapy. 61
17588239 2007
101
TC-PTP-deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-{gamma}. 61
17234741 2007
102
B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis. 61
17339439 2007
103
Relapsing Campylobacter coli bacteremia with reactive arthritis in a patient with X-linked agammaglobulinemia. 61
17473499 2007
104
T and B lymphocytes exert distinct effects on the homeostasis of NK cells. 61
16955521 2006
105
[Validation of a Bruton's disease genetic analysis method]. 61
17040875 2006
106
Effects of long-term low-dose corticosteroid therapy on humoral immunity. 61
16892792 2006
107
Three-dimensional ultrasound in the prenatal diagnosis of cleidocranial dysplasia associated with B-cell immunodeficiency. 61
16619383 2006
108
Enteroviral meningoencephalitis in a patient with non-Hodgkin's lymphoma treated previously with rituximab. 61
16430465 2006
109
Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain. 61
16210339 2006
110
Deficiency of regulatory B cells increases allergic airway inflammation. 61
16389573 2005
111
Immunomodulatory effect of plasmids co-expressing cytokines in classical swine fever virus subunit gp55/E2-DNA vaccination. 61
15955282 2005
112
Deficiency of somatic hypermutation of immunoglobulin G transcripts is a better predictor of severe respiratory tract infections than lack of memory B cells in common variable immunodeficiency. 61
16133996 2005
113
Mucosal B cell deficiency in IgA-/- mice abrogates the development of allergic lung inflammation. 61
16002732 2005
114
Effects of combined T- and B-cell deficiency on murine ischemia reperfusion injury. 61
15888022 2005
115
Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection. 61
15297622 2004
116
B cell-dependent T cell development. 61
15176721 2004
117
[Vaccination of the immunocompromised host]. 61
15244047 2004
118
B-cell deficiency and reduced B-cell reconstitution in hemoglobin-deficit mice. 61
14662329 2003
119
A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans. 61
14660746 2003
120
Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. 61
14578183 2003
121
Impaired germinal center maturation in adenosine deaminase deficiency. 61
14607964 2003
122
B cell deficiency confers protection from renal ischemia reperfusion injury. 61
12960350 2003
123
Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I. 61
12759461 2003
124
The possibility of B-cell-dependent T-cell development. 61
12753501 2003
125
Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-kappa B. 61
12626529 2003
126
Overexpression of RANKL implicates IFN-beta-mediated elimination of B-cell precursors in the osteopetrotic bone of microphthalmic mice. 61
12568405 2003
127
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. 61
12446777 2002
128
B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null mice. 61
12426221 2002
129
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. 61
12384703 2002
130
A case of severe B cell deficiency after allogeneic stem cell transplantation. 61
12235525 2002
131
Successful immunosuppressive therapy with cyclosporine A for posthepatitis B-cell deficiency with activated cytoplasmic interferon--gamma-positive T-lymphocytes. 61
11999357 2002
132
The effect of immunosuppression on protective immunity of turkey poults against infection with turkey coronavirus. 61
11848129 2002
133
Essential immunoregulatory role for BCAP in B cell development and function. 61
11877477 2002
134
Fas ligand-expressing B-1a lymphocytes mediate CD4(+)-T-cell apoptosis during schistosomal infection: induction by interleukin 4 (IL-4) and IL-10. 61
11796615 2002
135
B-cell deficiency and type 1 diabetes. 61
11858222 2002
136
B-cell deficiency and type 1 diabetes. 61
11844863 2002
137
Composition of precursor B-cell compartment in bone marrow from patients with X-linked agammaglobulinemia compared with healthy children. 61
11809909 2002
138
Splenic T zone development is B cell dependent. 61
11733579 2001
139
Genetic studies of B-lymphocyte deficiency and mastocytosis in strain A/WySnJ mice. 61
11862404 2001
140
Cutting edge: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis. 61
11714762 2001
141
Treatment of childhood autoimmune haemolytic anaemia with rituximab. 61
11705566 2001
142
B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. 61
11598082 2001
143
Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. 61
11591325 2001
144
Development of type 1 diabetes despite severe hereditary B-cell deficiency. 61
11586956 2001
145
Factors influencing B lymphopoiesis after allogeneic hematopoietic cell transplantation. 61
11435323 2001
146
Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. 61
11104803 2000
147
B-Cell deficiency predisposes mice to disseminating anaerobic infections: protection by passive antibody transfer. 61
10992465 2000
148
A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15. 61
11003386 2000
149
Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. 61
10933392 2000
150
Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. 61
10811867 2000
151
Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses. 61
10692003 2000
152
Common variable immunodeficiency in miniature dachshunds affected with Pneumonocystis carinii pneumonia. 61
10690774 2000
153
Microphthalmic mice display a B cell deficiency similar to that seen for mast and NK cells. 61
10586063 1999
154
[The role of salivary immunoglobulins (secretory IgA, IgM, IgG) in caries prevalence and primary B-cell deficiency]. 61
10628067 1999
155
Scrapie pathogenesis in subclinically infected B-cell-deficient mice. 61
10516067 1999
156
Complex requirements for nascent and memory immunity in pulmonary histoplasmosis. 61
10358191 1999
157
Susceptibility of B-cell deficient C57BL/6 (microMT) mice to Neospora caninum infection. 61
10320620 1999
158
A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen. 61
9778529 1998
159
B-cell development: a comparison between mouse and man. 61
9785673 1998
160
Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase. 61
9736610 1998
161
The effect of B cell deficiency on the immune response to acetylcholine receptor and the development of experimental autoimmune myasthenia gravis. 61
9646836 1998
162
CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling. 61
9463412 1998
163
Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. 61
9419212 1998
164
B-cell deficiency does not abrogate development of cutaneous hyperplasia in mice inheriting the defective fibrillin-1 gene. 61
9451590 1997
165
Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. 61
9384572 1997
166
A pronounced thymic B cell deficiency in the spontaneously diabetic BB rat. 61
9164980 1997
167
Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. 61
9169723 1997
168
Acquired B lymphocyte deficiency and chronic enterocolitis in a 3-year-old quarter horse. 61
9239837 1997
169
Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression. 61
9058789 1997
170
Mycobacterium tuberculosis aerogenic rechallenge infections in B cell-deficient mice. 61
10209680 1997
171
Humoral immunodeficiency in patients after bone marrow transplantation. 61
8971382 1996
172
A novel mutation (Cys145-->Stop) in Bruton's tyrosine kinase is associated with newly diagnosed X-linked agammaglobulinemia in a 51-year-old male. 61
8898377 1996
173
Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan. 61
8695804 1996
174
Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse. 61
8752907 1996
175
Gene-targeted mice lacking B cells are unable to eliminate a blood stage malaria infection. 61
8786312 1996
176
High copy number I-Ab transgenes induce production of IgE through an interluekin 4-dependent mechanism. 61
8610148 1996
177
Immunoglobulin deficient mice generated by gene targeting as models for studying the immune response. 61
8884429 1996
178
Immunologic effects of low-dose polyethylene glycol-conjugated recombinant human interleukin-2 in common variable immunodeficiency. 61
7584674 1995
179
Differential sensitivity to transforming growth factor (TGF)-beta of CBA and of CBA/N B cells demonstrates that the IgG2b inducing factor in synovial fluid from rheumatoid arthritis patients is not identical to TGF-beta. 61
7794824 1995
180
Hemorrhagic enteritis virus induced changes in the lymphocyte subpopulations in turkeys and the effect of experimental immunodeficiency on viral pathogenesis. 61
7604531 1995
181
The Yaa gene-dependent B-cell deficiency worsens the generalized lymphadenopathy and autoimmunity of C57BL/6-gld male mice. 61
7835973 1994
182
Radiologic findings of adult primary immunodeficiency disorders. Contribution of CT. 61
7774325 1994
183
The resolution of acute malaria in a definitive model of B cell deficiency, the JHD mouse. 61
8157969 1994
184
Detection of cell specific cluster determinant expression by reverse transcriptase polymerase chain reaction. 61
7510756 1994
185
Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice. 61
8162018 1994
186
Distribution and phenotypes of duodenal intraepithelial gamma/delta T cells in patients with various types of primary B-cell deficiency. 61
8103721 1993
187
B-cell and T-regulatory cell dysfunction in six Chinese children with hypogammaglobulinaemia. 61
8319707 1993
188
Demonstrations of a B-cell population that regulates the immune response in spleens of mice infected with herpes simplex virus type I. 61
8453787 1993
189
[The characteristics of the lymphoid population in myelodysplastic states]. 61
8020698 1993
190
Intestinal intraepithelial gamma/delta T cells in B-cell deficiency. 61
8167738 1993
191
B cell deficiency progresses with lineage maturation in nude.X-linked immunodeficient mice B cell deficiency progresses with lineage maturation. 61
1385525 1992
192
B-less: a strain of profoundly B cell-deficient mice expressing a human lambda transgene. 61
1314882 1992
193
Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ mice. 61
2037009 1991
194
Immunobiology of the xenograft response: xenograft rejection in immunodeficient animals. 61
1990514 1991
195
Inverse correlation between natural antitumor antibodies and tumor susceptibility in individual xid-bearing mice. 61
2057021 1991
196
Is the DNA synthesis of pancreatic islets influenced by the MHC and/or the genetic background? 61
2691591 1989
197
Rheumatoid synovial fluid reconstitutes the B-cell defect in CBA/N mice. 61
2602914 1989
198
[Combined immunodeficiency in LEC (Long Evans Cinnamon) rats with spontaneous hepatitis]. 61
2796959 1989
199
The role of interleukin 2 in the regulation of proliferation and IgM synthesis of human newborn mononuclear cells. 61
2784745 1989
200
[Mechanisms of polyclonal tolerance induced by lipopolysaccharide and cyclophosphamide]. 61
3118987 1987
201
Studies of the role of B-cells in the resistance of mice to experimental candidiasis. 61
3321768 1987
202
Impaired T- and B-cell functions in patients with Hodgkin's disease. Reduced mitogenic responsibility and Il-2 production is not caused by defective CD4+-cells. 61
3496158 1987
203
Humoral immune deficiency in multiple myeloma patients due to compromised B-cell function. 61
3023434 1986
204
Generation of agammaglobulinaemic mice by prenatal and postnatal exposure to polyclonal or monoclonal anti-IgM antibodies. 61
3489985 1986
205
Humoral immunodeficiency. 61
2424651 1986
206
Noma in a full-term neonate. 61
3874741 1985
207
Fatal disseminated adenovirus infection featuring liver necrosis and prolonged viremia in an immunosuppressed child with malignant histiocytosis. 61
2994509 1985
208
Studies on experimental aspergillosis in immunodeficient mice. 61
6326425 1983
209
Syndrome of neutrophil agranulocytosis, hypogammaglobulinemia, and thymoma. 61
7115963 1982
210
B cell, helper T cell, and suppressor T cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation. 61
6277055 1982
211
Acquired immunity in B cell-deficient mice to challenge exposure following primary infection with Schistosoma mansoni. 61
6973286 1981
212
Lymphocyte populations in maintenance hemodialysis patients - reassessment and analysis of B cell subtypes. 61
7333042 1981
213
Cytomegalovirus-specific lymphocyte transformations in subjects of different ages with primary immunodeficiency. 61
6155348 1980
214
Experimental model of B-cell deficiency in mice. 61
6966610 1980
215
Immunocytological studies in a case of Bruton's disease. 61
6965479 1980
216
Schistosoma mansoni infection in intact and B cell deficient mice: the effect of pretreatment with BCG in these experimental models. 61
362959 1978
217
Effect of lipopolysaccharide on immunogenicity and tolerogenicity of HGG in C57BL/6J nude mice: evidence for a possible B cell deficiency. 61
72110 1977
218
Gastrointestinal complications of immunodeficiency syndromes. 61
346324 1977
219
Variation in T and B cell deficiency in different mouse allogeneic radiation chimeras. 61
4279262 1974

Variations for B Cell Deficiency

Expression for B Cell Deficiency

Search GEO for disease gene expression data for B Cell Deficiency.

Pathways for B Cell Deficiency

Pathways related to B Cell Deficiency according to GeneCards Suite gene sharing:

(showing 29, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 TNFRSF13C TNFRSF13B TEC SH2D1A PRKCD NFKB2
2
Show member pathways
13.3 TNFRSF13C TNFRSF13B TEC PRKCD CD40LG CD4
3
Show member pathways
13.22 TNFRSF13C TNFRSF13B PRKCD CD40LG CD4 CD27
4
Show member pathways
13.22 TNFRSF13C TNFRSF13B TEC PRKCD NFKB2 IRF4
5
Show member pathways
12.72 TNFRSF13C TNFRSF13B ICOSLG CD8A CD40LG CD4
6
Show member pathways
12.59 PRKCD CR2 CD40LG CD4 CD27
7
Show member pathways
12.55 NFKB2 ICOSLG CD40LG CD4 BTK
8
Show member pathways
12.51 TNFRSF13C TNFRSF13B PRKCD CD40LG CD27
9
Show member pathways
12.5 TEC PRKCD IRF4 CD8A CD40LG CD4
10
Show member pathways
12.34 TNFRSF13C TNFRSF13B NFKB2 CR2
11
Show member pathways
12.29 TEC PRKCD ICOSLG CD40LG CD4
12
Show member pathways
12.27 TEC PRKCD IRF4 CR2 CD19 BTK
13
Show member pathways
12.25 PRKCD CD4 CD19 BTK
14 12.17 TEC SH2D1A NFKB2 IRF4 IKZF1 CD8A
15 12.04 ICOSLG CD8A CD40LG CD4
16 11.99 SH2D1A CD8A CD40LG CD19
17 11.85 TNFRSF13C NFKB2 CD40LG BTK
18 11.82 CR2 CD8A CD4 CD19
19
Show member pathways
11.69 IRF4 IKZF1 CD40LG
20
Show member pathways
11.67 TNFRSF13B NFKB2 CD40LG
21 11.67 IRF4 IKZF1 CD8A CD4 CCR6
22 11.66 PRKCD CD4 BTK
23 11.59 IRF4 CD40LG AICDA
24 11.54 ICOSLG CD40LG CD27
25 11.52 IRF4 IKZF1 CD8A CD4 CD19
26 11.43 TEC NFKB2 BTK
27 11.36 TNFRSF13B CR2 CD40LG CD4 CD27 CD19
28 10.86 TNFRSF13C TNFRSF13B IGLL1 CD8A CD40LG CD4
29 10.75 IRF4 IKZF1

GO Terms for B Cell Deficiency

Cellular components related to B Cell Deficiency according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.77 TNFRSF13C TNFRSF13B TEC PRKCD ICOSLG CR2
2 external side of plasma membrane GO:0009897 9.28 TNFRSF13C IGLL1 ICOSLG CD8A CD40LG CD4

Biological processes related to B Cell Deficiency according to GeneCards Suite gene sharing:

(showing 15, show less)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 IGLL1 CR2 CD8A CD40LG CD4 CCR6
2 cell surface receptor signaling pathway GO:0007166 9.83 TNFRSF13B CD8A CD4 CD27
3 B cell receptor signaling pathway GO:0050853 9.73 TEC IGLL1 CD19 BTK
4 regulation of immune response GO:0050776 9.72 SH2D1A ICOSLG CD8A CD40LG CD19
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.71 TNFRSF13C TNFRSF13B CD40LG CD27
6 B cell differentiation GO:0030183 9.69 CR2 CD40LG AICDA
7 positive regulation of T cell proliferation GO:0042102 9.67 TNFRSF13C CD40LG CD4
8 T cell costimulation GO:0031295 9.65 TNFRSF13C ICOSLG CD40LG
9 B cell proliferation GO:0042100 9.63 PRKCD CR2 CD40LG
10 adaptive immune response GO:0002250 9.56 TNFRSF13C TNFRSF13B TEC SH2D1A ICOSLG CD4
11 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.55 IRF4 CD4
12 positive regulation of B cell differentiation GO:0045579 9.54 CD27 BTK
13 T cell activation GO:0042110 9.46 IRF4 ICOSLG CD8A CD4
14 immunoglobulin mediated immune response GO:0016064 9.43 PRKCD CD27 CD19
15 immune system process GO:0002376 9.36 TNFRSF13C TNFRSF13B TEC SH2D1A IRF4 ICOSLG

Molecular functions related to B Cell Deficiency according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 non-membrane spanning protein tyrosine kinase activity GO:0004715 8.8 TEC PRKCD BTK

Sources for B Cell Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....