BCGF
MCID: BCL014
MIFTS: 32

B-Cell Growth Factor (BCGF)

Aliases & Classifications for B-Cell Growth Factor

MalaCards integrated aliases for B-Cell Growth Factor:

Name: B-Cell Growth Factor 57
B-Cell Growth Factor 1; Bcgf1 57
B-Cell Growth Factor 1 57
Bcgf1 57
Bcgf 57

External Ids:

OMIM® 57 109540

Summaries for B-Cell Growth Factor

MalaCards based summary : B-Cell Growth Factor, also known as b-cell growth factor 1; bcgf1, is related to cryptococcal meningitis and leukemia, chronic lymphocytic. An important gene associated with B-Cell Growth Factor is TXLNA (Taxilin Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include b cells, t cells and bone.

More information from OMIM: 109540

Related Diseases for B-Cell Growth Factor

Diseases related to B-Cell Growth Factor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 cryptococcal meningitis 29.9 TNFSF13 IFNG
2 leukemia, chronic lymphocytic 29.8 TNFSF13 IL7 IL6 IL4
3 burkitt lymphoma 29.6 IL7 IL6 IL4
4 tetanus 29.4 IL6 IL4 IFNG
5 pulmonary fibrosis, idiopathic 29.2 IL6 IL4 IFNG
6 autoimmune disease 29.0 TNFSF13 IL6 IL4 IFNG
7 common variable immunodeficiency 28.7 TNFSF13 IL7 IL6 IL4 IFNG
8 leukemia 10.4
9 b-cell lymphoma 10.4
10 leukemia, acute lymphoblastic 10.4
11 hairy cell leukemia 10.4
12 systemic lupus erythematosus 10.3
13 thymoma, familial 10.3
14 thymoma 10.3
15 lupus erythematosus 10.3
16 lymphoma 10.2
17 toxic oil syndrome 10.2 IL4 IFNG
18 orofacial granulomatosis 10.2 IL4 IFNG
19 pemphigoid 10.1 IL4 IFNG
20 vernal conjunctivitis 10.1 IL4 IFNG
21 retinitis pigmentosa 46 10.1 IL4 IFNG
22 nickel allergic contact dermatitis 10.1 IL4 IFNG
23 tungiasis 10.1 IL4 IFNG
24 mucocutaneous leishmaniasis 10.1 IL4 IFNG
25 strongyloidiasis 10.1 IL4 IFNG
26 penicillin allergy 10.1 IL4 IFNG
27 acute graft versus host disease 10.1 IL4 IFNG
28 urinary schistosomiasis 10.1 IL4 IFNG
29 scleritis 10.1 IL4 IFNG
30 latex allergy 10.1 IL4 IFNG
31 eczema herpeticum 10.1 IL4 IFNG
32 hypersplenism 10.1 IL4 IFNG
33 folliculitis 10.1 IL4 IFNG
34 cryptococcosis 10.1 IL4 IFNG
35 poliomyelitis 10.1 IL4 IFNG
36 peanut allergy 10.1 IL4 IFNG
37 trichinosis 10.1 IL4 IL3
38 ige responsiveness, atopic 10.1 IL4 IFNG
39 intrinsic asthma 10.1 IL4 IL3
40 lepromatous leprosy 10.1 IL4 IFNG
41 allergic bronchopulmonary aspergillosis 10.1 IL4 IFNG
42 eosinophilic gastroenteritis 10.1 IL4 IL3
43 allergic conjunctivitis 10.1 IL4 IFNG
44 prolymphocytic leukemia 10.1
45 respiratory allergy 10.0 IL4 IL3
46 esophagitis, eosinophilic, 1 10.0 IL4 IL3
47 eosinophilic pneumonia 10.0 IL4 IL3
48 autoimmune uveitis 10.0 IL4 IFNG
49 acute gonococcal cervicitis 10.0 IL6 IL4
50 severe combined immunodeficiency, x-linked 10.0 IL7 IL4

Graphical network of the top 20 diseases related to B-Cell Growth Factor:



Diseases related to B-Cell Growth Factor

Symptoms & Phenotypes for B-Cell Growth Factor

Clinical features from OMIM®:

109540 (Updated 20-May-2021)

Drugs & Therapeutics for B-Cell Growth Factor

Search Clinical Trials , NIH Clinical Center for B-Cell Growth Factor

Genetic Tests for B-Cell Growth Factor

Anatomical Context for B-Cell Growth Factor

MalaCards organs/tissues related to B-Cell Growth Factor:

40
B Cells, T Cells, Bone, Bone Marrow, Lung, Lymph Node, Myeloid

Publications for B-Cell Growth Factor

Articles related to B-Cell Growth Factor:

(show top 50) (show all 710)
# Title Authors PMID Year
1
Molecular cloning and expression of a human B-cell growth factor gene in Escherichia coli. 57 61
3547651 1987
2
Evidence for an intracellular precursor for human B-cell growth factor. 61 57
6083564 1984
3
Association between B Cell Growth Factors and Primary Sjögren's Syndrome-Related Autoantibodies in Patients with Non-Hodgkin's Lymphoma. 61
30766889 2019
4
Expression of the B cell differentiation factor BAFF and chemokine CXCL13 in a murine model of Respiratory Syncytial Virus infection. 61
29396045 2018
5
Histological and immunohistochemical evaluation of mandibular bone tissue regeneration. 61
30350738 2018
6
Impact of the B Cell Growth Factor APRIL on the Qualitative and Immunological Characteristics of Atherosclerotic Plaques. 61
27820817 2016
7
PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment. 61
24881819 2014
8
Biochemical assessment of growth factors and circulation of blood components contained in the different fractions obtained by centrifugation of venous blood. 61
25001662 2014
9
Revisiting the identification and cDNA cloning of T cell-replacing factor/interleukin-5. 61
25566252 2014
10
Pillars article: Identification of a T cell-derived B cell growth factor distinct from interleukin 2. J. Exp. Med. 1982. 155: 914-923. 61
23335802 2013
11
Serum BAFF levels are related to angiogenesis and prognosis in patients with multiple myeloma. 61
22498341 2012
12
Molecular cloning and expression analysis of a thioredoxin from rock bream, Oplegnathus fasciatus, and biological activity of the recombinant protein. 61
21402159 2011
13
Identification of a sub-population of B cells that proliferates after infection with Epstein-Barr virus. 61
21352549 2011
14
Immunodeficient NOD-scid IL-2Rγ(null) mice do not display T and B cell leakiness. 61
21512274 2011
15
Human herpesvirus 8-encoded cytokines. 61
20436945 2010
16
The effects of IL-6 on CD4 T cell responses. 61
18845487 2009
17
Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. 61
19029902 2009
18
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. 61
19139170 2009
19
Regulation of human interleukin 14 transcription in vitro and in vivo after renal transplantation. 61
18645499 2008
20
Development of a murine model for blastoid variant mantle-cell lymphoma. 61
17311992 2007
21
[Therapeutic effects and prognostic factors in tonsillectomy patients with IgA nephropathy]. 61
17373325 2007
22
Development of autoimmunity in IL-14alpha-transgenic mice. 61
17015757 2006
23
The SDF-1 G > A polymorphism at position 801 plays no role in multiple myeloma but may contribute to an inferior cause-specific survival in chronic lymphocytic leukemia. 61
16923552 2006
24
Role of interleukin-7 in bone and T-cell homeostasis. 61
16313348 2005
25
A role for B cell-activating factor of the TNF family in chemically induced autoimmunity. 61
16237113 2005
26
Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. 61
16010409 2005
27
Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1alpha in the circulation. 61
15718415 2005
28
SLE - Complex cytokine effects in a complex autoimmune disease: tumor necrosis factor in systemic lupus erythematosus. 61
12823847 2003
29
Cloning of the rat IL-5Ralpha gene: analysis of 5'-upstream region and expression by B cells. 61
11606047 2001
30
Molecular identification of IgE-dependent histamine-releasing factor as a B cell growth factor. 61
11359806 2001
31
Thioredoxin acts as a B cell growth factor in channel catfish. 61
11207242 2001
32
[Effect of 6A8 alpha-mannosidase expression on the proliferative response of human B cell line 3D5]. 61
12903396 2000
33
Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis. 61
10805212 2000
34
Interleukin-4 and breast cancer. 61
11029795 2000
35
Serum sCD23 level in patients with AIDS-related non-Hodgkin's lymphoma is associated with absence of Epstein-Barr virus in tumor tissue. 61
10600334 1999
36
Cytokine expression in B-CLL in relation to disease progression and in vitro activation. 61
10618692 1999
37
Serum soluble CD23 level correlates with subsequent development of AIDS-related non-Hodgkin's lymphoma. 61
10566552 1999
38
Preparation of recombinant rat interleukin-5 by baculovirus expression system and analysis of its biological activities. 61
10446387 1999
39
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. 61
10398604 1999
40
Differential cytokine responses of CD4+ and CD8+ T cells in response to bovine viral diarrhoea virus in cattle. 61
10423135 1999
41
Effects of interleukin 3, interleukin 7, and B-cell growth factor on proliferation and drug resistance in vitro in childhood acute lymphoblastic leukemia. 61
10348147 1999
42
Differential modulation of immune recognition molecules by interleukin-7 in human acute leukaemias. 61
10210778 1999
43
Analysis of biological activities of recombinant rat interleukin-5. 61
10529595 1999
44
Castleman's disease. 61
10655569 1999
45
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis. 61
11056663 1999
46
Sequential changes in CGRP-like immunoreactivity in NIDDM model Otsuka Long-Evans Tokushima Fatty (OLETF) rat pancreatic islets. 61
9667523 1998
47
Growth factor-like action of lysophosphatidic acid on human B lymphoblasts. 61
9611122 1998
48
Interleukin-7 (IL-7) enhances class switching to IgE and IgG4 in the presence of T cells via IL-9 and sCD23. 61
9454766 1998
49
Increased production of B-cell growth factor by T lymphocytes in Graves' thyroid: possible role of CD4+ CD29+ cells. 61
9292944 1997
50
Jak3 activation in human lymphocyte precursor cells. 61
9182906 1997

Variations for B-Cell Growth Factor

Expression for B-Cell Growth Factor

Search GEO for disease gene expression data for B-Cell Growth Factor.

Pathways for B-Cell Growth Factor

Pathways related to B-Cell Growth Factor according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 TXLNA TNFSF13 IL7 IL6 IL4 IL3
2
Show member pathways
13.4 TNFSF13 IL7 IL6 IL4 IL3 IFNG
3
Show member pathways
13.28 IL7 IL6 IL4 IL3 IFNG
4
Show member pathways
13.16 TNFSF13 IL7 IL6 IL4 IL3
5
Show member pathways
13.06 TNFSF13 IL7 IL6 IL4 IL3
6
Show member pathways
12.91 TXLNA TNFSF13 IL7 IL6 IL4 IL3
7
Show member pathways
12.76 IL7 IL6 IL4 IL3
8 12.58 IL7 IL6 IL4 IL3 IFNG
9
Show member pathways
12.57 TNFSF13 IL6 IL4 IL3 IFNG
10
Show member pathways
12.4 IL6 IL4 IFNG
11
Show member pathways
12.39 IL6 IL4 IFNG
12 12.36 IL4 IL3 IFNG
13
Show member pathways
12.31 IL4 IL3 IFNG
14
Show member pathways
12.14 IL6 IL4 IFNG
15
Show member pathways
12.14 IL6 IL4 IFNG
16
Show member pathways
12.12 IL7 IL6 IL4 IL3 IFNG
17
Show member pathways
12.03 IL6 IL4 IL3 IFNG
18
Show member pathways
12.01 IL6 IL4 IFNG
19 11.79 IL6 IL3 IFNG
20 11.78 TNFSF13 IL6 IL4 IFNG
21 11.71 TNFSF13 IL6 IFNG
22
Show member pathways
11.69 IL6 IL4 IFNG
23 11.66 IL7 IL6 IL4 IL3
24 11.64 IL6 IL4 IFNG
25 11.62 IL7 IL4 IFNG
26
Show member pathways
11.57 IL4 IL3 IFNG
27 11.49 TNFSF13 IL6 IL4
28 11.43 IL6 IFNG
29 11.42 IL7 IL6 IL4 IL3 IFNG
30 11.4 IL6 IFNG
31 11.38 IL6 IFNG
32 11.37 IL6 IL4
33 11.35 IL6 IL3
34 11.35 IL6 IL3
35 11.32 IL4 IFNG
36 11.31 IL6 IFNG
37 11.22 IL6 IFNG
38 11.17 IL4 IFNG
39 11.05 IL4 IFNG
40 10.96 IL7 IL6 IL4 IFNG
41 10.78 TNFSF13 IL7 IL6 IL4 IL3
42 10.68 IL6 IL4
43 10.48 IL7 IL6 IL4 IL3 IFNG

GO Terms for B-Cell Growth Factor

Cellular components related to B-Cell Growth Factor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 TNFSF13 IL7 IL6 IL4 IL3 IFNG
2 extracellular region GO:0005576 9.17 TXLNA TNFSF13 IL7 IL6 IL4 IL3

Biological processes related to B-Cell Growth Factor according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.78 IL7 IL6 IL4 IFNG
2 cytokine-mediated signaling pathway GO:0019221 9.65 TXLNA IL7 IL6 IL4 IL3
3 positive regulation of interleukin-1 beta production GO:0032731 9.57 IL6 IFNG
4 positive regulation of B cell proliferation GO:0030890 9.56 IL7 IL4
5 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.55 IL7 IL4
6 positive regulation of interleukin-10 production GO:0032733 9.54 IL6 IL4
7 humoral immune response GO:0006959 9.54 IL7 IL6 IFNG
8 B cell activation GO:0042113 9.52 TXLNA IL4
9 microglial cell activation GO:0001774 9.51 IL4 IFNG
10 positive regulation of chemokine production GO:0032722 9.5 IL7 IL6 IFNG
11 positive regulation of T cell differentiation GO:0045582 9.49 IL7 IL4
12 positive regulation of MHC class II biosynthetic process GO:0045348 9.46 IL4 IFNG
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 IL6 IL4 IL3 IFNG
14 positive regulation of cellular respiration GO:1901857 9.43 IL4 IFNG
15 positive regulation of cell proliferation GO:0008284 9.43 TNFSF13 IL7 IL6 IL4 IL3 IFNG
16 neuroinflammatory response GO:0150076 9.4 IL4 IFNG
17 immune response GO:0006955 9.1 TNFSF13 IL7 IL6 IL4 IL3 IFNG

Molecular functions related to B-Cell Growth Factor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL7 IL6 IL4 IL3
2 cytokine receptor binding GO:0005126 9.16 IL7 IL4
3 cytokine activity GO:0005125 9.1 TNFSF13 IL7 IL6 IL4 IL3 IFNG

Sources for B-Cell Growth Factor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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