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MCID: BCL006
MIFTS: 66

B-Cell Lymphomas

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for B-Cell Lymphomas

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MalaCards integrated aliases for B-Cell Lymphomas:

Name: B-Cell Lymphomas 39 77 74
B-Cell Lymphoma 12 54 30 15
Lymphoma, B-Cell 54 45 41
B-Cell Lymphocytic Neoplasm 12
Lymphoma B-Cell 56

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Blood diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:707
MeSH 45 D016393
NCIt 51 C27907 C3457
SNOMED-CT 69 1929004
UMLS 74 C0079731
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Summaries for B-Cell Lymphomas

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NIH Rare Diseases : 54 B-cell lymphoma refers to types of non-Hodgkin lymphoma that are characterized by abnormalities of the "B-cells" (a type of white blood cell that makes antibodies to help fight infection). The condition may grow and spread slowly with few symptoms (also known as indolent lymphoma) or may be very aggressive with severe symptoms. When present, signs and symptoms may include swollen lymph nodes in the neck, armpit, or groin; abdominal pain; fatigue; fever; night sweats; and/or weight loss. The underlying cause of B-cell lymphoma is poorly understood. However, the condition can be associated with genetic abnormalities, environmental factors, viruses, immunodeficiency states, and connective-tissue disorders. Treatment is based on many factors, including the severity of the condition and the associated signs and symptoms.

MalaCards based summary : B-Cell Lymphomas, also known as b-cell lymphoma, is related to nodal marginal zone b-cell lymphoma and primary cutaneous marginal zone b-cell lymphoma. An important gene associated with B-Cell Lymphomas is MIR17 (MicroRNA 17), and among its related pathways/superpathways are NF-kappaB Signaling and T cell receptor signaling pathway. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A non-Hodgkin lymphoma that has material basis in B cells.

Wikipedia : 77 Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell). The... more...

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Related Diseases for B-Cell Lymphomas

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Diseases in the B-Cell Lymphomas family:

T-Cell Lymphoma 1a

Diseases related to B-Cell Lymphomas via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 683)
# Related Disease Score Top Affiliating Genes
1 nodal marginal zone b-cell lymphoma 34.8 BCL6 MALT1
2 primary cutaneous marginal zone b-cell lymphoma 34.8 BCL10 IRF4 MALT1
3 relapsed/refractory diffuse large b-cell lymphoma 34.8 FOXP1 IRF4
4 t-cell/histiocyte rich large b cell lymphoma 34.8 BCL6 MME
5 primary mediastinal large b-cell lymphoma 34.7 BCL6 FOXP1 IRF4 MYC
6 marginal zone b-cell lymphoma 34.7 BCL10 BCL6 CCND1 FOXP1 IRF4 MALT1
7 intravascular large b-cell lymphoma 34.6 BCL6 MME
8 diffuse large b-cell lymphoma 34.5 BCL10 BCL6 FOXP1 HOTAIR IRF4 MALT1
9 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 34.3 BCL6 MYC
10 lymphoma, mucosa-associated lymphoid type 34.2 BCL10 BCL6 CCND1 FOXP1 IRF4 MALT1
11 splenic marginal zone lymphoma 33.5 BCL6 MALT1 PAX5
12 follicular lymphoma 33.3 BCL10 BCL6 CCND1 IRF4 MME MYC
13 primary effusion lymphoma 33.2 BCL6 IRF4 MYC
14 reticulosarcoma 32.7 BCL6 CCND3 PAX5
15 mature b-cell neoplasm 32.7 BCL6 MME MYC PVT1
16 lymphoma 32.4 BCL10 BCL6 CCND1 GAS5 MALT1 MYC
17 burkitt lymphoma 32.3 BCL6 CCND3 MME MYC PAX5 PVT1
18 leukemia, chronic lymphocytic 31.4 BCL10 BCL6 CCND1 PAX5
19 nodular lymphocyte predominant hodgkin lymphoma 31.3 BCL6 PAX5
20 lymphoma, hodgkin, classic 31.3 BCL6 MIR20A MME PAX5 PVT1
21 lymphocytic leukemia 31.2 HOTAIR MME MYC PAX5
22 composite lymphoma 31.1 BCL6 PAX5
23 plasmacytoma 31.0 IRF4 MYC PVT1
24 central nervous system lymphoma 31.0 BCL6 FOXP1 MALT1
25 cll/sll 30.9 CCND1 MME PAX5
26 follicular lymphoma 1 30.8 BCL10 BCL6
27 chromosomal triplication 30.7 BCL6 MALT1
28 bladder lymphoma 30.6 MME PAX5
29 lymphoma, non-hodgkin, familial 30.6 BCL10 BCL6 CCND1 CCND3 CDKN1B IRF4
30 lung lymphoma 30.4 BCL6 MALT1 PAX5
31 intestinal disease 30.4 BCL6 CCND1 MYC
32 mantle cell lymphoma 30.3 BCL6 CCND1 CCND3 CDKN1B GAS5 MALAT1
33 retinoblastoma 29.8 CCND1 CCND3 HOTAIR MALAT1
34 leukemia, acute myeloid 29.5 HOTAIR MALAT1 MME MYC TUG1
35 squamous cell carcinoma 29.4 CCND1 CDKN1B HOTAIR MALAT1 TUG1
36 thyroid cancer, nonmedullary, 1 29.3 GAS5 HOTAIR MALAT1 PVT1
37 cholangiocarcinoma 29.2 CCND1 CDKN1B MALAT1 MME TUG1
38 thyroid cancer 29.1 CCND1 CDKN1B GAS5 HOTAIR MALAT1 MYC
39 nasopharyngeal carcinoma 28.9 CCND1 GAS5 HOTAIR MALAT1 MYC PVT1
40 glioblastoma 28.9 CCND1 CDKN1B GAS5 HOTAIR MALAT1 MYC
41 small cell cancer of the lung 28.8 HOTAIR MALAT1 MYC PAX5 TUG1
42 myeloma, multiple 28.8 CCND1 CCND3 GAS5 HOTAIR IRF4 MALAT1
43 lung cancer susceptibility 3 28.8 CCND1 GAS5 HOTAIR MALAT1 TUG1
44 renal cell carcinoma, nonpapillary 28.6 GAS5 HOTAIR MALAT1 MME PVT1 TUG1
45 osteogenic sarcoma 28.4 GAS5 HOTAIR MALAT1 PVT1 TUG1
46 bladder cancer 28.2 CCND1 GAS5 HOTAIR MALAT1 MYC PVT1
47 glioma 28.1 CCND1 GAS5 HOTAIR MALAT1 MIR17 MIR20A
48 ovarian cancer 28.1 CCND1 CDKN1B GAS5 HOTAIR MALAT1 MYC
49 breast cancer 28.0 CCND1 CCND3 CDKN1B GAS5 HOTAIR MALAT1
50 gastric cancer 28.0 CCND1 CDKN1B GAS5 HOTAIR MALAT1 MIR20A

Graphical network of the top 20 diseases related to B-Cell Lymphomas:



Diseases related to B-Cell Lymphomas
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Symptoms & Phenotypes for B-Cell Lymphomas

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MGI Mouse Phenotypes related to B-Cell Lymphomas:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 BCL10 BCL6 CCND1 CCND3 CDKN1B IRF4
2 immune system MP:0005387 9.7 BCL10 BCL6 CCND1 CCND3 CDKN1B IRF4
3 neoplasm MP:0002006 9.1 CCND1 CCND3 CDKN1B IRF4 MYC PAX5
Sources

Drugs & Therapeutics for B-Cell Lymphomas

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Drugs for B-Cell Lymphomas (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 639)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
3
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2068-78-2, 57-22-7 5978
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
6
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
7
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
8
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 23214-92-8 31703
9
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
10
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
11
Gemcitabine Approved Phase 4,Phase 2,Phase 3,Phase 1 95058-81-4 60750
12
Cytarabine Approved, Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 147-94-4, 65-46-3 6253
13
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 441203 84093 2767
14
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 33419-42-0 36462
15
Oxaliplatin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 61825-94-3 6857599 5310940 9887054 43805
16
Epirubicin Approved Phase 4,Phase 3,Phase 2,Not Applicable 56420-45-2 41867
17
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1959-05-2, 59-05-2 126941
18
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 174722-31-7 10201696
19
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 135968-09-1
20
Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52-24-4 5453
21
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 58-05-9 6006 143
22
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 59917-39-4, 53643-48-4 40839
23
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 3778-73-2 3690
24
Decitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 2353-33-5 451668
25
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754
26
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-03-3
27
Azacitidine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 320-67-2 9444
28
Ribavirin Approved Phase 4,Phase 3 36791-04-5 37542
29
Sofosbuvir Approved Phase 4,Phase 2 1190307-88-0 45375808
30
Ledipasvir Approved Phase 4,Phase 2 1256388-51-8 67505836
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-30-3 6037
32
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
33
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 31703
34
Tenofovir Experimental, Investigational Phase 4,Phase 2 147127-20-6 464205
35 Prednisolone acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
38 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
43 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
45 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Methylprednisolone Acetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 2056)
# Name Status NCT ID Phase Drugs
1 Treatment of Diffuse Large B Cell Lymphoma Unknown status NCT01949818 Phase 4 Yangzhengxiaoji capsule combined with CHOP regimen;CHOP regimen
2 PEG-rhG-CSF in Patients With Non-Hodgkin Lymphoma Receiving Chemotherapy to Prevent Neutropenia Unknown status NCT02996617 Phase 4 rhG-CSF regimen;Pegylated rhG-CSF regimen
3 To Compare the Efficacy of a Prophylactic Use of Tenofovir by Duration for the Non-Hodgkin's Lymphoma Unknown status NCT02585947 Phase 4 Tenofovir
4 LINFOTARGAM: Treatment With Chemotherapy Plus Rituximab and Highly Active Antiretroviral Therapy in Patients With Diffuse Large B Cell Lymphoma and Infection With the Human Immunodeficiency Virus (HIV) Completed NCT00466258 Phase 4 R-CHOP;Highly active antiretroviral therapy;Central nervous system (CNS) prophylaxis;Prophylaxis of opportunistic infections and support treatment
5 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
6 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
7 Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma Recruiting NCT03513601 Phase 4 (R)-CHOP regimen;(R)-CVP regimen
8 A Clinical Trial of Decitabine in Relapse and Refractory Diffuse Large B Cell Lymphoma Recruiting NCT03579082 Phase 4 Decitabine
9 Treatment of Relapsed /Refractory Diffuse Large B Cell Lymphoma Recruiting NCT03376958 Phase 4 Apatinib
10 Reduced Chemotherapy in Low Risk DLBCL Recruiting NCT02752815 Phase 4 Rituximab;Cyclophosphamide;Epirubicin;Vincristine;Prednisone
11 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
12 A Study of Brentuximab Vedotin in Participants With Relapsed or Refractory Hodgkin Lymphoma Active, not recruiting NCT01990534 Phase 4 Brentuximab vedotin
13 Extended Treatment Protocol for Subjects Continuing to Benefit From Ibrutinib. Enrolling by invitation NCT03229200 Phase 4 Ibrutinib
14 Anti-CD19:TCRζ Chimeric Antigen Receptor-T Cells in the Treatment for CD19+ B Cell Lymphoma Not yet recruiting NCT02992834 Phase 4
15 Oral Hepatitis C Treatment for Indolent Lymphoma (OPTImaL) Study Terminated NCT02717949 Phase 4 sofosbuvir/ledipasvir;sofosbuvir;Ribavirin
16 Biocell Natural Killer Mixture in Diffuse Large B Cell Lymphoma (DLBCL) Patients Unknown status NCT00846157 Phase 3
17 Dose Dense Chemotherapy + Rituximab +/-Intensified High Dose Chemoimmunotherapy With Support of Peripheral Autologous Stem Cell in Diffuse Large B-Cell Lymphoma Unknown status NCT00499018 Phase 3 Rituximab;Ciclofosfamide;Doxorubicina;Vincristina;Prednisone;Pegfilgrastim;Mitoxantrone;ARA-C;Lenograstim;BCNU;ARA-C;VP-16;Ciclofosfamide;Doxorubicina;Vincristina
18 A Study Comparing the Efficacy and Safety Between I-CHOP and R-CHOP in Untreated CD20-Positive Diffuse Large B-cell Lymphoma Patients Unknown status NCT02867566 Phase 3 IBI301 plus CHOP;Rituximab plus CHOP
19 MabionCD20® Compared to MabThera® in Lymphoma Patients Unknown status NCT02617485 Phase 3 Rituximab;Doxorubicin;Vincristine;Cyclophosphamide;prednisone
20 30Gy Versus 40Gy Involved-field Radiotherapy for Localized Diffuse Large B Cell Lymphoma Achieving CR After Chemotherapy Unknown status NCT01156259 Phase 3
21 Multiple Fields Radiotherapy Versus Intravenous Rituximab in the Treatment of Indolent Cutaneous Lymphomas B-cell With Multiple or Recurrent Lesions Unknown status NCT02867553 Phase 3 rituximab
22 TREatment of degeNerative and Neoplastic Diseases With Rituximab Unknown status NCT01277172 Phase 2, Phase 3
23 Study Comparing the Zevalin Regimen With no Further Treatment in DLBCL Patients Who Are in Complete Remission After CHOP-R Unknown status NCT00322218 Phase 3 Zevalin Therapeutic Regimen
24 Incidence of Hepatitis B Virus (HBV) Reactivation in HBsAg Negative/HBcAb Positive Lymphoma Patients Treated With RCHOP Unknown status NCT01210287 Phase 2, Phase 3 nucleoside analog reverse transcriptase inhibitor
25 Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma Unknown status NCT00003650 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisone;vincristine sulfate
26 Epratuzumab in Treating Patients With Non-Hodgkin's Lymphoma Unknown status NCT00022685 Phase 3
27 Rituximab Maintenance Therapy in Aggressive CD20 (Cluster of Differentiation Antigen 20) Positive Lymphoma and Mantle Cell Lymphoma Unknown status NCT01933711 Phase 3 rituximab
28 Immunotherapy in Peripheral T Cell Lymphoma - the Role of Alemtuzumab in Addition to Dose Dense CHOP Unknown status NCT00725231 Phase 3 chemotherapy
29 Helicobacter – Lymphoma – Radiation Part I: Eradication, Part II: Radiation Unknown status NCT00154440 Phase 3 proton pump inhibitor;clarithromycin;amoxicillin;metronidazole
30 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
31 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
32 Fludarabine and Rituximab With or Without Pixantrone in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin Lymphoma Unknown status NCT00551239 Phase 3 fludarabine phosphate;pixantrone dimaleate
33 Epoetin Alfa or Epoetin Beta With or Without Iron Infusion in Treating Anemia in Patients With Cancer Unknown status NCT00482716 Phase 3
34 Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma Unknown status NCT00003639 Phase 3 chlorambucil;dexamethasone;idarubicin
35 Interferon Alfa-2b Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma Unknown status NCT00003924 Phase 3
36 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
37 Monoclonal Antibodies in Detecting Residual Disease in Patients Who Have Been Treated for Non-Hodgkin's Lymphoma Unknown status NCT00003338 Phase 2, Phase 3
38 Radiolabeled Monoclonal Antibody in the Detection and Staging of Patients With Non-Hodgkin's Lymphoma Unknown status NCT00003337 Phase 3
39 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
40 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
41 LMBA02 Protocol for Patients With a Burkitt Lymphoma Unknown status NCT00180882 Phase 3 rituximab
42 Study of Lenalidomide to Evaluate Safety and Effectiveness in Patients With Diffuse Large B-Cell Lymphoma (DLBCL) Completed NCT01197560 Phase 2, Phase 3 Lenalidomide;Gemcitabine;Oxaliplatin;Rituximab;Etoposide
43 Treatment of Mature B-cell Lymphoma/Leukaemia Completed NCT00162656 Phase 3 half cyclophosphamide;without COPADM3;mini CYVE, without 3 maintenance courses;LMB B;LMB C
44 Phase III Study of RAD001 Adjuvant Therapy in Poor Risk Patients With Diffuse Large B-Cell Lymphoma (DLBCL) of RAD001 Versus Matching Placebo After Patients Have Achieved Complete Response With First-line Rituximab-chemotherapy Completed NCT00790036 Phase 3 Everolimus;Everolimus Placebo
45 A Study of Obinutuzumab in Combination With CHOP Chemotherapy Versus Rituximab With CHOP in Participants With CD20-Positive Diffuse Large B-Cell Lymphoma (GOYA) Completed NCT01287741 Phase 3 Rituximab;Obinutuzumab;Cyclophosphamide;Doxorubicin;Vincristine;Prednisone
46 Rituximab+Standard CHOP vs Rituximab+Bi-weekly CHOP for Untreated Stage III/IV Low-grade B-cell Lymphoma (JCOG0203) Completed NCT00147121 Phase 2, Phase 3 Rituximab + Standard CHOP;Rituximab + Bi-weekly CHOP
47 A Study of Participant Preference With Subcutaneous Versus Intravenous MabThera/Rituxan in Participants With CD20+ Diffuse Large B-Cell Lymphoma or CD20+ Follicular Non-Hodgkin's Lymphoma Grades 1, 2 or 3a Completed NCT01724021 Phase 3 Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisone/Prednisolone (CHOP);Cyclophosphamide, Vincristine, Prednisone/Prednisolone (CVP);Bendamustine;Rituximab;Rituximab;Rituximab;Rituximab
48 A Multicentre, Randomized Phase III Study of Rituximab as Maintenance Treatment Versus Observation in Patients With Aggressive B-cell Lymphoma: NHL-13 Completed NCT00400478 Phase 3 Rituximab
49 A Randomised Evaluation of Molecular Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib Completed NCT01324596 Phase 3 Intravenous;Bortezomib
50 ACVBP Plus Rituximab Versus CHOP Plus Rituximab in Patients With Diffuse Large B-cell Lymphoma and Age-adjusted IPI of 1 Completed NCT00140595 Phase 3 rituximab;doxorubicin;cyclophosphamide

Search NIH Clinical Center for B-Cell Lymphomas

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about B-Cell Lymphomas cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for B-Cell Lymphomas:
Blood stem cell transplantation for hematological diseases
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to B-Cell Lymphomas:
Peripheral blood-derived hematopoietic stem cells (family)
Bone marrow-derived hematopoietic stem cells

Cochrane evidence based reviews: lymphoma, b-cell

Sources

Genetic Tests for B-Cell Lymphomas

About this section

Genetic tests related to B-Cell Lymphomas:

# Genetic test Affiliating Genes
1 B-Cell Lymphoma 30
Sources

Anatomical Context for B-Cell Lymphomas

About this section

MalaCards organs/tissues related to B-Cell Lymphomas:

42
B Cells, T Cells, Bone, Bone Marrow, Breast, Lymph Node, Liver
Sources

Publications for B-Cell Lymphomas

About this section

Articles related to B-Cell Lymphomas:

(show top 50) (show all 7812)
# Title Authors Year
1
Outcome of patients receiving consolidative autologous peripheral blood stem cell transplantation in the frontline treatment of intravascular large B-cell lymphoma: Adult Lymphoma Working Group of the Japan Society for Hematopoietic Cell Transplantation. ( 30809035 )
2019
2
Validation of CD137 Immunohistochemical Stain on Paraffin-Embedded Tissue as a Marker to Facilitate Distinction Between Classic Hodgkin Lymphoma, Nodular Lymphocyte-Predominant Hodgkin Lymphoma, T-Cell/Histiocyte-Rich Large B-Cell Lymphoma, and Anaplastic Large Cell Lymphoma. ( 30816829 )
2019
3
Risk of HBV reactivation in patients with B-cell lymphomas receiving obinutuzumab or rituximab immunochemotherapy. ( 30341058 )
2019
4
Epstein-Barr Virus Infection of Cell Lines Derived from Diffuse Large B-Cell Lymphomas Alters MicroRNA Loading of the Ago2 Complex. ( 30429351 )
2019
5
Can We Exploit the Molecular Heterogeneity of Aggressive B Cell Lymphomas Into Effective New Therapies? ( 30555036 )
2019
6
Epstein-Barr virus LMP2A utilizes Syk and PI3K to activate NF-κB in B-cell lymphomas to increase MIP-1α production. ( 30609049 )
2019
7
Phase 1 study of lenalidomide plus dose-adjusted EPOCH-R in patients with aggressive B-cell lymphomas with deregulated MYC and BCL2. ( 30707764 )
2019
8
Primary Cutaneous Large B-Cell Lymphomas: relevance of the 2017 WHO Classification. ( 30715765 )
2019
9
MYD88 L265P mutation and CDKN2A loss are early mutational events in primary central nervous system diffuse large B-cell lymphomas. ( 30723112 )
2019
10
LMO2 Negative Expression Predicts the Presence of MYC Translocations in Aggressive B-Cell Lymphomas: Erratum. ( 30724749 )
2019
11
Nuclear factor erythroid 2-related factors 1 and 2 are able to define the worst prognosis group among high-risk diffuse large B cell lymphomas treated with R-CHOEP. ( 30755497 )
2019
12
Porpaczy E, Tripolt S, Hoelbl-Kovacic A, et al. Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy. Blood. 2018;132(7):694-706. ( 30765499 )
2019
13
Origin and Pathogenesis of B Cell Lymphomas. ( 30779028 )
2019
14
Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas. ( 30779034 )
2019
15
RNA Sequencing in B-Cell Lymphomas. ( 30779040 )
2019
16
HDAC3 inhibition up-regulates PD-L1 expression in B-cell lymphomas and augments the efficacy of anti-PD-L1 therapy. ( 30824609 )
2019
17
Growth-inhibition of cell lines derived from B cell lymphomas through antagonism of serotonin receptor signaling. ( 30862884 )
2019
18
Molecular pathogenesis of germinal center-derived B cell lymphomas. ( 30874347 )
2019
19
Epstein Barr Virus Associated B-Cell Lymphomas and Iatrogenic Lymphoproliferative Disorders. ( 30899698 )
2019
20
The utility of prognostic indices, early events, and histological subtypes on predicting outcomes in non-follicular indolent B-cell lymphomas. ( 30916801 )
2019
21
Unusual case of human herpesvirus 8-positive large B-cell lymphoma associated with Castleman disease. ( 30899504 )
2019
22
Splenic Marginal Zone B-Cell Lymphoma With Splenic Infarction in a Patient With Cold Agglutinin Disease. ( 30888998 )
2019
23
Diffuse large B-cell lymphoma of the central nervous system presenting as "lymphomatosis cerebri" and dementia in elderly man: Case report and review of the literature. ( 30732171 )
2019
24
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma. ( 30790227 )
2019
25
Serum level of soluble interleukin-2 receptor is positively correlated with metabolic tumor volume on 18 F-FDG PET/CT in newly diagnosed patients with diffuse large B-cell lymphoma. ( 30790452 )
2019
26
Fibrin-associated diffuse large B-cell lymphoma confined to a cardiac myxoma. ( 30792226 )
2019
27
CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type. ( 30792929 )
2019
28
Prognostic impact of MYD88 mutation, proliferative index and cell origin in diffuse large B cell lymphoma. ( 30793105 )
2019
29
Phase 2 Study of Daratumumab in Relapsed/Refractory Mantle-Cell Lymphoma, Diffuse Large B-Cell Lymphoma, and Follicular Lymphoma. ( 30795996 )
2019
30
Concomitant Treatment of Hepatitis C Virus and Diffuse Large B-Cell Lymphoma with Direct-Acting Antivirals in HIV Coinfection: A Case Report. ( 30798652 )
2019
31
Unraveling transformation of follicular lymphoma to diffuse large B-cell lymphoma. ( 30802265 )
2019
32
Impact of intended and relative dose intensity of R-CHOP in a large, consecutive cohort of elderly Diffuse large B cell lymphoma (DLBCL) patients treated with curative intent: no difference in cumulative incidence of relapse comparing patients by age. ( 30811713 )
2019
33
Dose-adjusted EPOCH-R therapy in MYC-rearranged diffuse large B-cell lymphoma: not yet the standard of care. ( 30824036 )
2019
34
Dose-adjusted EPOCH-R therapy in MYC-rearranged diffuse large B-cell lymphoma: not yet the standard of care - Authors' reply. ( 30824037 )
2019
35
L-type Cav 1.2 Calcium Channel-a-1C regulates response to rituximab in Diffuse Large B-cell Lymphoma. ( 30824586 )
2019
36
Clinical features and outcome of the patients with sinonasal tract diffuse large B-cell lymphoma in the pre and rituximab eras. ( 30834564 )
2019
37
Pediatric Diffuse Large B-Cell Lymphoma of the Frontal Sinus: A Case Report. ( 30836788 )
2019
38
Diffuse Large B-Cell Lymphoma Involvement in Two Different Localizations: A Case Report. ( 30838336 )
2019
39
Effect of rituximab combined with chemotherapy on the expression of serum exosome miR-451a in patients with diffuse large b-cell lymphoma. ( 30840285 )
2019
40
Role of Epstein Barr virus in transformation of follicular lymphoma to diffuse large B-cell lymphoma: a case report and review of the literature. ( 30846502 )
2019
41
Direct Costs Associated with Relapsed Diffuse Large B-Cell Lymphoma Therapies. ( 30850561 )
2019
42
Primary cutaneous diffuse large B-cell lymphoma, NOS and leg type: Clinical, morphologic and prognostic differences. ( 30851152 )
2019
43
18F-FDG PET/CT imaging findings of extensive neurolymphomatosis as a relapse of diffuse large B cell lymphoma. ( 30853415 )
2019
44
Identification of B-cell translocation gene 1-controlled gene networks in diffuse large B-cell lymphoma: A study based on bioinformatics analysis. ( 30854058 )
2019
45
Economic burden and treatment patterns for patients with diffuse large B-cell lymphoma and follicular lymphoma in the USA. ( 30855175 )
2019
46
Phase II Study of Dose-Reduced Consolidation Radiation Therapy in Diffuse Large B-cell Lymphoma. ( 30858144 )
2019
47
Diffuse Large B cell Lymphoma: 2019 update on diagnosis, risk-stratification and treatment. ( 30859597 )
2019
48
Diffuse Large B-cell Lymphoma Presenting as Bilateral Renal Masses: Successful Treatment with Dose-adjusted REPOCH (Rituximab, Etoposide, Prednisone, Vincristine, Cyclophosphamide, Doxorubicin) Chemotherapy Regimen. ( 30868028 )
2019
49
Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma. ( 30871527 )
2019
50
Modelling dose and schedule effects of AZD2811 nanoparticles targeting aurora kinase B for treatment of diffuse large B-cell lymphoma. ( 30872381 )
2019
Sources

Variations for B-Cell Lymphomas

About this section

Cosmic variations for B-Cell Lymphomas:

9 (show top 50) (show all 51)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6986772 TRAF2 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.152A>G p.H51R 9:136898892-136898892 0
2 COSM10648 TP53 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.524G>A p.R175H 17:7675088-7675088 0
3 COSM44910 TP53 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.403T>A p.C135S 17:7675209-7675209 0
4 COSM10995 TP53 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.580C>T p.L194F 17:7674951-7674951 0
5 COSM4721653 RICTOR haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.3712C>T p.R1238* 5:38950136-38950136 0
6 COSM190567 RHOA haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.206T>C p.L69P 3:49368499-49368499 0
7 COSM5274 PTEN haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.484G>C p.D162H 10:87933243-87933243 0
8 COSM6987562 PTEN haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.331T>G p.W111G 10:87933090-87933090 0
9 COSM5036 PTEN haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.202T>C p.Y68H 10:87925550-87925550 0
10 COSM30627 PIK3CA haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.3109G>A p.E1037K 3:179234266-179234266 0
11 COSM85940 MYD88 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.794T>C p.L265P 3:38141150-38141150 0
12 COSM6987557 MSH6 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.493T>C p.F165L 2:47795929-47795929 0
13 COSM2006760 KMT2D haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.12952C>T p.Q4318* 12:49030678-49030678 0
14 COSM6987497 KDM6A haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.3406A>G p.M1136V 23:45083581-45083581 0
15 COSM6949886 HGF haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.986G>T p.W329L 7:81729659-81729659 0
16 COSM6948355 GRIN2A haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.2453C>T p.A818V 16:9768993-9768993 0
17 COSM37031 EZH2 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.1936T>A p.Y646N 7:148811636-148811636 0
18 COSM37029 EZH2 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.1937A>C p.Y646S 7:148811635-148811635 0
19 COSM52944 DNMT3A haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.2645G>A p.R882H 2:25234373-25234373 0
20 COSM6987563 DIS3 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.2597A>C p.K866T 13:72761436-72761436 0
21 COSM6987564 CTCF haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.1282C>G p.Q428E 16:67621516-67621516 0
22 COSM12475 CDKN2A haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.238C>T p.R80* 9:21971121-21971121 0
23 COSM22488 ATM haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.8494C>T p.R2832C 11:108345818-108345818 0
24 COSM21828 ATM haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.2932T>C p.S978P 11:108271261-108271261 0
25 COSM21829 ATM haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.8138G>A p.R2713K 11:108335096-108335096 0
26 COSM6987565 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.403T>A p.C135S 17:7675209-7675209 0
27 COSM6987567 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.403T>A p.C135S 17:7675209-7675209 0
28 COSM99914 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.524G>A p.R175H 17:7675088-7675088 0
29 COSM99023 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.128G>A p.R43H 17:7675088-7675088 0
30 COSM442676 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.2078G>A p.R693H 2:25234373-25234373 0
31 COSM376384 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.184C>T p.L62F 17:7674951-7674951 0
32 COSM99022 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.524G>A p.R175H 17:7675088-7675088 0
33 COSM3355994 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.524G>A p.R175H 17:7675088-7675088 0
34 COSM446026 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.3109G>A p.E1037K 3:179234266-179234266 0
35 COSM2006759 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.13762C>T p.Q4588* 12:49030678-49030678 0
36 COSM6987566 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.403T>A p.C135S 17:7675209-7675209 0
37 COSM1679502 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.580C>T p.L194F 17:7674951-7674951 0
38 COSM1640851 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.524G>A p.R175H 17:7675088-7675088 0
39 COSM6987496 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.3406A>G p.M1136V 23:45083581-45083581 0
40 COSM376383 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.301C>T p.L101F 17:7674951-7674951 0
41 COSM6987498 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.3427A>G p.M1143V 23:45083581-45083581 0
42 COSM6987569 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.124T>A p.C42S 17:7675209-7675209 0
43 COSM6987570 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.7T>A p.C3S 17:7675209-7675209 0
44 COSM376381 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.580C>T p.L194F 17:7674951-7674951 0
45 COSM99024 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.245G>A p.R82H 17:7675088-7675088 0
46 COSM5416224 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.818T>C p.L273P 3:38141150-38141150 0
47 COSM6986773 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.152A>G p.H51R 9:136898892-136898892 0
48 COSM4721652 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.3712C>T p.R1238* 5:38950136-38950136 0
49 COSM6987568 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.403T>A p.C135S 17:7675209-7675209 0
50 COSM376382 haematopoietic and lymphoid tissue,lymph node,lymphoid neoplasm,B cell lymphoma unspecified c.580C>T p.L194F 17:7674951-7674951 0
Sources

Expression for B-Cell Lymphomas

About this section
Search GEO for disease gene expression data for B-Cell Lymphomas.
Sources

Pathways for B-Cell Lymphomas

About this section

Pathways related to B-Cell Lymphomas according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
12.4 BCL10 BCL6 IRF4 MALT1 PAX5 REL
2
T cell receptor signaling pathway 38
Show member pathways
 12.33 BCL10 IRF4 MALT1 REL
3
MicroRNAs in cancer 38
12.32 CCND1 CDKN1B FOXP1 MIR17 MIR20A MYC
4
Development IGF-1 receptor signaling 23
Show member pathways
 12.28 CCND1 CCND3 CDKN1B MYC REL
5
Cell cycle 38 1
12.27 CCND1 CCND3 CDKN1B MYC
6
Viral carcinogenesis 38
12.19 CCND1 CCND3 CDKN1B REL
7
MAPK Signaling: Mitogen Stimulation Pathway 66
Show member pathways
 12.11 CCND1 CCND3 CDKN1B MYC
8
Cell cycle Role of SCF complex in cell cycle regulation 23
Show member pathways
 12.1 CCND1 CCND3 CDKN1B MYC
9
Transcriptional misregulation in cancer 38
12.1 BCL6 CDKN1B MYC PAX5 REL
10
Spinal Cord Injury 1
11.89 CCND1 CDKN1B MYC
11
Interleukin-4 and 13 signaling 67
11.87 BCL6 CCND1 IRF4 MYC
12
Glioblastoma Multiforme 65
11.85 CCND1 CDKN1B MYC
13
B cell receptor signaling pathway (KEGG) 38
Show member pathways
 11.81 BCL10 BCL6 IRF4 MALT1 MYC REL
14
Small cell lung cancer 38
11.77 CCND1 CDKN1B MYC
15
Retinoblastoma (RB) in Cancer 1
11.72 CCND1 CCND3 CDKN1B MYC
16
C-MYB transcription factor network 1
11.65 CCND1 CDKN1B MYC PAX5
17
E2F transcription factor network 1
11.64 CCND3 CDKN1B MYC
18
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.61 CCND3 CDKN1B MYC
19
DNA Damage Response (only ATM dependent) 1
11.61 BCL6 CCND1 CCND3 CDKN1B MYC
20
Regulation of Telomerase 1
11.59 CCND1 CDKN1B MYC
21
Validated targets of C-MYC transcriptional repression 1
11.54 CCND1 CDKN1B MYC
22
IL-2 Gene Expression in Activated and Quiescent T-Cells 65
Show member pathways
 11.52 CCND1 CDKN1B MYC REL
23
B Cell Development Pathways 66
11.47 BCL6 MME PAX5
24
DNA Damage Response 1
Show member pathways
 11.47 CCND1 CCND3 CDKN1B MIR17 MIR20A MYC
25
IL-7 Signaling Pathway 1
Show member pathways
 11.39 CCND1 CDKN1B MYC
26
miRNAs involved in DNA damage response 1
11.32 CCND1 CCND3 CDKN1B MYC
27
IL-10 Pathway 65
11.26 CCND1 CCND3 MYC
28
DNA damage_ATM/ATR regulation of G1/S checkpoint 23
11.2 CCND1 CCND3 MYC REL
Sources

GO Terms for B-Cell Lymphomas

About this section

Cellular components related to B-Cell Lymphomas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CBM complex GO:0032449 8.62 BCL10 MALT1

Biological processes related to B-Cell Lymphomas according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.93 BCL6 CCND1 CCND3 MYC PAX5 REL
2 cytokine-mediated signaling pathway GO:0019221 9.84 BCL6 CCND1 IRF4 MYC
3 G1/S transition of mitotic cell cycle GO:0000082 9.7 CCND1 CDKN1B MYC
4 negative regulation of gene expression GO:0010629 9.69 MIR17 MIR20A REL
5 negative regulation of toll-like receptor signaling pathway GO:0034122 9.56 IRF4 MIR17
6 response to estradiol GO:0032355 9.55 CCND1 CDKN1B
7 response to molecule of bacterial origin GO:0002237 9.49 BCL10 MALT1
8 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.48 MIR17 MIR20A
9 negative regulation of B cell apoptotic process GO:0002903 9.43 BCL6 FOXP1
10 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.43 CCND1 CCND3 CDKN1B
11 response to fungus GO:0009620 9.4 BCL10 MALT1
12 regulation of T cell receptor signaling pathway GO:0050856 9.32 BCL10 MALT1
13 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.16 MIR17 MIR20A
14 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 9.13 CCND1 CCND3 CDKN1B
15 re-entry into mitotic cell cycle GO:0000320 9.07 CCND1
16 positive regulation of cell cycle GO:0045787 8.8 CCND1 CCND3 CDKN1B

Molecular functions related to B-Cell Lymphomas according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.73 BCL6 FOXP1 IRF4 MYC PAX5 REL
2 kinase activator activity GO:0019209 9.16 BCL10 MALT1
3 protein self-association GO:0043621 9.13 BCL10 FOXP1 MALT1
4 cyclin-dependent protein serine/threonine kinase activity GO:0004693 8.8 CCND1 CCND3 CDKN1B
Sources

Sources for B-Cell Lymphomas

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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