MCID: BLY009
MIFTS: 24

B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

MalaCards integrated aliases for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like:

Name: B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like 12 15
B-All Bcr-Abl1-Like 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080650

Summaries for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Disease Ontology : 12 A B-lymphoblastic leukemia/lymphoma that has a gene expression profile similar to that of B-ALL with t(9;22)(q34.1;q11.2) BCR-ABL1, but lacks that gene fusion.

MalaCards based summary : B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like, also known as b-all bcr-abl1-like, is related to b-cell adult acute lymphocytic leukemia and adult acute lymphocytic leukemia. An important gene associated with B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like is ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Pathways in cancer and MicroRNAs in cancer. Affiliated tissues include b lymphoblasts and testes, and related phenotypes are liver/biliary system and respiratory system

Related Diseases for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Diseases in the B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1 family:

B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Diseases related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 36, show less)
# Related Disease Score Top Affiliating Genes
1 b-cell adult acute lymphocytic leukemia 9.9 IKZF1 ABL1
2 adult acute lymphocytic leukemia 9.9 IKZF1 ABL1
3 b-lymphoblastic leukemia/lymphoma with iamp21 9.9 IKZF1 ABL1
4 childhood b-cell acute lymphoblastic leukemia 9.9 IKZF1 CDKN2A
5 central nervous system lymphoma 9.9 FOXP1 CDKN2A
6 childhood acute lymphocytic leukemia 9.9 IKZF1 ABL1
7 childhood leukemia 9.9 CDKN2A ABL1
8 dermatofibrosarcoma protuberans 9.8 CDKN2A ABL1
9 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 9.8 JAK2 ABL1
10 lymphoblastic leukemia, acute, with lymphomatous features 9.8 JAK2 ABL1
11 acquired polycythemia 9.8 JAK2 ABL1
12 myelophthisic anemia 9.8 JAK2 ABL1
13 myelodysplastic/myeloproliferative neoplasm 9.7 JAK2 ABL1
14 chronic neutrophilic leukemia 9.7 JAK2 ABL1
15 atypical chronic myeloid leukemia 9.7 JAK2 ABL1
16 chronic eosinophilic leukemia 9.7 JAK2 ABL1
17 epstein-barr virus-associated gastric carcinoma 9.7 JAK2 CDKN2A
18 chronic leukemia 9.7 JAK2 ABL1
19 precursor t-cell acute lymphoblastic leukemia 9.6 IKZF1 CDKN2A ABL1
20 t-cell acute lymphoblastic leukemia 9.6 IKZF1 CDKN2A ABL1
21 bone marrow cancer 9.4 JAK2 ABL1
22 gastrointestinal stromal tumor 9.4 JAK2 CDKN2A ABL1
23 mental retardation, autosomal dominant 33 9.4 JAK2 IKZF1 ABL1
24 diffuse large b-cell lymphoma 9.3 JAK2 FOXP1 CDKN2A
25 hypereosinophilic syndrome 9.3 JAK2 ABL1
26 leukemia, chronic myeloid 9.2 JAK2 IKZF1 ABL1
27 hematologic cancer 9.2 JAK2 IKZF1 ABL1
28 leukemia, acute lymphoblastic 3 9.2 IKZF1 FOXP1 CDKN2A ABL1
29 leukemia, chronic lymphocytic 9.2 JAK2 CDKN2A ABL1
30 lymphoma, non-hodgkin, familial 9.1 JAK2 IKZF1 CDKN2A
31 myelodysplastic syndrome 9.1 JAK2 CDKN2A ABL1
32 leukemia 9.0 JAK2 IKZF1 CDKN2A ABL1
33 leukemia, acute lymphoblastic 9.0 JAK2 IKZF1 CDKN2A ABL1
34 myeloma, multiple 8.9 JAK2 IKZF1 CDKN2A ABL1
35 leukemia, acute myeloid 8.9 JAK2 IKZF1 CDKN2A ABL1
36 b-cell lymphoma 8.9 JAK2 IKZF1 FOXP1 CDKN2A

Graphical network of the top 20 diseases related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like:



Diseases related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Symptoms & Phenotypes for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

MGI Mouse Phenotypes related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like:

45 (showing 2, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.26 ABL1 CDKN2A IKZF1 JAK2
2 respiratory system MP:0005388 8.92 ABL1 CDKN2A IKZF1 JAK2

Drugs & Therapeutics for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Search Clinical Trials , NIH Clinical Center for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Genetic Tests for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Anatomical Context for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

MalaCards organs/tissues related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like:

40
B Lymphoblasts, Testes

Publications for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Articles related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like:

(showing 5, show less)
# Title Authors PMID Year
1
BCR-ABL1-like B-Lymphoblastic Leukemia/Lymphoma with FOXP1-ABL1 Rearrangement: Comprehensive Laboratory Identification Allowing Tyrosine Kinase Inhibitor Use. 61
30938769 2019
2
BCR-ABL1-like B-lymphoblastic leukemia/lymphoma: Review of the entity and detection methodologies. 61
31069976 2019
3
Hematopoietic neoplasms with 9p24/JAK2 rearrangement: a multicenter study. 61
30401948 2019
4
Updates in the Pathology of Precursor Lymphoid Neoplasms in the Revised Fourth Edition of the WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. 61
29951888 2018
5
Laboratory testing in BCR-ABL1-like (Philadelphia-like) B-lymphoblastic leukemia/lymphoma. 61
29696694 2018

Variations for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Expression for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Search GEO for disease gene expression data for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like.

Pathways for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Pathways related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like according to GeneCards Suite gene sharing:

(showing 5, show less)
# Super pathways Score Top Affiliating Genes
1 12.16 JAK2 CDKN2A ABL1
2 11.82 FOXP1 CDKN2A ABL1
3 11.38 CDKN2A ABL1
4
Show member pathways
10.3 CDKN2A ABL1
5 9.97 CDKN2A ABL1

GO Terms for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Cellular components related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like according to GeneCards Suite gene sharing:

(showing 2, show less)
# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.02 JAK2 IKZF1 FOXP1 CDKN2A ABL1
2 postsynapse GO:0098794 8.96 JAK2 ABL1

Biological processes related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like according to GeneCards Suite gene sharing:

(showing 16, show less)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.7 JAK2 CDKN2A ABL1
2 apoptotic process GO:0006915 9.69 JAK2 CDKN2A ABL1
3 negative regulation of transcription, DNA-templated GO:0045892 9.61 IKZF1 FOXP1 CDKN2A
4 peptidyl-tyrosine phosphorylation GO:0018108 9.56 JAK2 ABL1
5 cell cycle arrest GO:0007050 9.55 CDKN2A ABL1
6 response to oxidative stress GO:0006979 9.54 JAK2 ABL1
7 positive regulation of apoptotic process GO:0043065 9.5 JAK2 CDKN2A ABL1
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.49 JAK2 ABL1
9 regulation of inflammatory response GO:0050727 9.48 JAK2 FOXP1
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.46 JAK2 CDKN2A
11 positive regulation of endothelial cell migration GO:0010595 9.4 FOXP1 ABL1
12 erythrocyte differentiation GO:0030218 9.37 JAK2 IKZF1
13 mesoderm development GO:0007498 9.26 JAK2 IKZF1
14 platelet-derived growth factor receptor signaling pathway GO:0048008 9.16 JAK2 ABL1
15 negative regulation of cell-cell adhesion GO:0022408 8.96 JAK2 ABL1
16 negative regulation of ubiquitin-protein transferase activity GO:0051444 8.62 CDKN2A ABL1

Molecular functions related to B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like according to GeneCards Suite gene sharing:

(showing 5, show less)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.62 IKZF1 FOXP1 CDKN2A ABL1
2 kinase activity GO:0016301 9.33 JAK2 CDKN2A ABL1
3 protein tyrosine kinase activity GO:0004713 9.26 JAK2 ABL1
4 non-membrane spanning protein tyrosine kinase activity GO:0004715 8.96 JAK2 ABL1
5 SH2 domain binding GO:0042169 8.62 JAK2 ABL1

Sources for B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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