MCID: BLY002
MIFTS: 24

B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

MalaCards integrated aliases for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1:

Name: B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1 12 15
B Lymphoblastic Leukemia/lymphoma with T(9;22)(q34.1;q11.2); Bcr-Abl1 6
B-Lymphoblastic Leukemia/lymphoma with T(9;22)(q34.1;q11.2);bcr-Abl1 12
B-All with Bcr-Abl1 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080643
NCIt 50 C80331

Summaries for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Disease Ontology : 12 A B-lymphoblastic leukemia/lymphoma that derives from B-lymphoblasts and carries a translocation between the BCR gene on chromosome 22 and the ABL1 gene on chromosome 9. It results in the production of the p190 kd or p210 kd fusion protein.

MalaCards based summary : B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1, also known as b lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2); bcr-abl1, is related to acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) and lymphoblastic leukemia, acute, with lymphomatous features. An important gene associated with B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1 is ABL2 (ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase), and among its related pathways/superpathways are Pathways in cancer and Ras signaling pathway. Affiliated tissues include b lymphoblasts, and related phenotype is cellular.

Related Diseases for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Diseases in the B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1 family:

B-Lymphoblastic Leukemia/lymphoma, Bcr-Abl1-Like

Diseases related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0 KMT2A CSF1R
2 lymphoblastic leukemia, acute, with lymphomatous features 9.9 CRLF2 ABL1
3 acquired polycythemia 9.9 EPOR ABL1
4 central nervous system leukemia 9.9 KMT2A ABL1
5 adult acute lymphocytic leukemia 9.9 CRLF2 ABL1
6 leukemia, acute lymphoblastic 3 9.9 KMT2A ABL1
7 myelodysplastic/myeloproliferative neoplasm 9.9 KMT2A ABL1
8 chronic neutrophilic leukemia 9.8 KMT2A ABL1
9 childhood b-cell acute lymphoblastic leukemia 9.8 P2RY8 CRLF2
10 childhood leukemia 9.8 KMT2A ABL1
11 precursor t-cell acute lymphoblastic leukemia 9.7 KMT2A ABL1
12 acute megakaryocytic leukemia 9.7 KMT2A EPOR
13 chromosomal duplication syndrome 9.6 P2RY8 CRLF2
14 myeloid leukemia 9.6 KMT2A CSF1R ABL1
15 leukemia, chronic myeloid 9.6 KMT2A EPOR ABL1
16 hematologic cancer 9.6 KMT2A CSF1R ABL1
17 mental retardation, autosomal dominant 33 9.5 P2RY8 CRLF2 ABL1
18 leukemia 9.5 KMT2A CRLF2 ABL2 ABL1
19 myeloproliferative neoplasm 9.4 KMT2A EPOR CSF1R ABL1
20 myelodysplastic syndrome 9.4 KMT2A EPOR CSF1R ABL1
21 b-lymphoblastic leukemia/lymphoma with iamp21 9.3 P2RY8 KMT2A CRLF2 ABL1
22 leukemia, acute lymphoblastic 9.2 KMT2A EPOR CSF1R CRLF2 ABL1

Graphical network of the top 20 diseases related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1:



Diseases related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Symptoms & Phenotypes for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

MGI Mouse Phenotypes related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.1 ABL1 ABL2 CRLF2 CSF1R EPOR KMT2A

Drugs & Therapeutics for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Search Clinical Trials , NIH Clinical Center for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Genetic Tests for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Anatomical Context for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

MalaCards organs/tissues related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1:

40
B Lymphoblasts

Publications for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Articles related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1:

# Title Authors PMID Year
1
B-acute lymphoblastic leukemia/lymphoblastic lymphoma. 61
26276770 2015

Variations for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

ClinVar genetic disease variations for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MSH6 NM_000179.2(MSH6):c.2588A>G (p.Glu863Gly) SNV Uncertain significance 229858 rs876658238 2:48027710-48027710 2:47800571-47800571
2 APC NM_000038.6(APC):c.2993G>T (p.Gly998Val) SNV Uncertain significance 233564 rs759579036 5:112174284-112174284 5:112838587-112838587

Expression for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Search GEO for disease gene expression data for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1.

Pathways for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Pathways related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.16 EPOR CSF1R ABL1
2
Show member pathways
11.98 CSF1R ABL2 ABL1
3 11.32 EPOR CSF1R
4
Show member pathways
10.8 ABL2 ABL1
5 10.3 ABL2 ABL1

GO Terms for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

Biological processes related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.54 EPOR CSF1R CRLF2
2 regulation of autophagy GO:0010506 9.46 ABL2 ABL1
3 regulation of hematopoietic stem cell differentiation GO:1902036 9.43 KMT2A ABL1
4 regulation of cell adhesion GO:0030155 9.4 ABL2 ABL1
5 peptidyl-tyrosine phosphorylation GO:0018108 9.33 CSF1R ABL2 ABL1
6 regulation of endocytosis GO:0030100 9.32 ABL2 ABL1
7 regulation of cell motility GO:2000145 9.26 ABL2 ABL1
8 positive regulation of oxidoreductase activity GO:0051353 8.96 ABL2 ABL1
9 regulation of actin cytoskeleton reorganization GO:2000249 8.8 CSF1R ABL2 ABL1

Molecular functions related to B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.61 CSF1R ABL2 ABL1
2 manganese ion binding GO:0030145 9.4 ABL2 ABL1
3 cytokine receptor activity GO:0004896 9.37 EPOR CRLF2
4 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.32 ABL2 ABL1
5 phosphotyrosine residue binding GO:0001784 9.26 ABL2 ABL1
6 cytokine binding GO:0019955 9.16 CSF1R CRLF2
7 actin monomer binding GO:0003785 8.96 ABL2 ABL1
8 protein tyrosine kinase activity GO:0004713 8.8 CSF1R ABL2 ABL1

Sources for B-Lymphoblastic Leukemia/lymphoma with Bcr-Abl1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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