MCID: BLY006
MIFTS: 26

B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

MalaCards integrated aliases for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

Name: B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy 12 15
B Lymphoblastic Leukemia/lymphoma with Hypodiploidy 6
B-All with Hypodiploidy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0080647
NCIt 49 C80338

Summaries for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Disease Ontology : 12 A B-lymphoblastic leukemia/lymphoma that is composed of B-lymphoblasts which contain less than 46 chromosomes.

MalaCards based summary : B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy, also known as b lymphoblastic leukemia/lymphoma with hypodiploidy, is related to pheochromocytoma-paraganglioma and extra-adrenal pheochromocytoma. An important gene associated with B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Developmental Biology and Endometrial cancer. Affiliated tissues include b lymphoblasts, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Diseases related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 pheochromocytoma-paraganglioma 10.3 SDHA RET
2 extra-adrenal pheochromocytoma 10.3 SDHA RET
3 esophagus leiomyoma 10.2 SDHA RET
4 adrenal medulla cancer 10.2 SDHA RET
5 cebpa-associated familial acute myeloid leukemia 10.2 ETV6 CEBPA
6 cerebellar angioblastoma 10.2 SDHA ETV6
7 autonomic nervous system benign neoplasm 10.2 SDHA RET
8 peripheral nervous system benign neoplasm 10.2 SDHA RET
9 persistent generalized lymphadenopathy 10.1 SDHA RET
10 loeffler endocarditis 10.1 IL3 ETV6
11 mental retardation, autosomal dominant 29 10.0 PBX1 ABL1
12 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.0 SDHA RET APC
13 b-cell adult acute lymphocytic leukemia 10.0 PBX1 ABL1
14 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.0 ETV6 ABL1
15 testicular leukemia 10.0 ETV6 ABL1
16 paraganglioma and gastric stromal sarcoma 10.0 SDHA RET
17 b-lymphoblastic leukemia/lymphoma 9.9 TCF3 RET CEBPA APC
18 b-lymphoblastic leukemia/lymphoma with iamp21 9.8 PBX1 ETV6 ABL1
19 myelodysplastic/myeloproliferative neoplasm 9.7 ETV6 ABL1
20 acute leukemia 9.6 TCF3 IL3 ETV6 CEBPA
21 adult acute lymphocytic leukemia 9.5 TCF3 PBX1 ETV6 ABL1
22 polycythemia vera 9.5 IL3 ETV6 ABL1
23 leukemia, acute lymphoblastic 3 9.5 TCF3 PBX1 ETV6 ABL1
24 childhood acute lymphocytic leukemia 9.5 TCF3 PBX1 ETV6 ABL1
25 childhood leukemia 9.5 TCF3 PBX1 ETV6 ABL1
26 atypical chronic myeloid leukemia 9.5 ETV6 ABL1
27 mental retardation, autosomal dominant 33 9.4 IGHV4-38-2 ETV6 ABL1
28 myeloproliferative neoplasm 9.4 IL3 ETV6 ABL1
29 myeloid leukemia 9.4 IL3 ETV6 CEBPA ABL1
30 leukemia 9.3 TCF3 PBX1 ETV6 CEBPA ABL1
31 bone marrow cancer 9.3 IL3 IGHV4-38-2 ABL1
32 lymphoma, non-hodgkin, familial 9.1 IL3 IGHV4-38-2 ETV6 APC
33 hematologic cancer 8.8 IL3 IGHV4-38-2 ETV6 APC ABL1
34 leukemia, acute lymphoblastic 8.3 TCF3 PBX1 IL3 IGHV4-38-2 ETV6 APC
35 leukemia, acute myeloid 8.3 TCF3 PBX1 IL3 IGHV4-38-2 ETV6 CEBPA
36 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 7.1 TCF3 RET PBX1 MICU1 IL3 IGHV4-38-2

Graphical network of the top 20 diseases related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:



Diseases related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Symptoms & Phenotypes for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

GenomeRNAi Phenotypes related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.53 MICU1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.53 MICU1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.53 APC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.53 MICU1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.53 MICU1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.53 MICU1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.53 MICU1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.53 TCF3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.53 APC
10 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.53 MICU1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.53 APC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-34 9.53 MICU1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.53 CEBPA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.53 CEBPA TCF3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.53 MICU1

MGI Mouse Phenotypes related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.19 ABL1 APC CEBPA EDIL3 ETV6 FARSA
2 homeostasis/metabolism MP:0005376 10.16 ABL1 APC CEBPA EDIL3 ETV6 FARSA
3 cellular MP:0005384 10.15 ABL1 APC CEBPA EDIL3 ETV6 PBX1
4 endocrine/exocrine gland MP:0005379 10.11 ABL1 APC CEBPA EDIL3 ETV6 PBX1
5 digestive/alimentary MP:0005381 10.08 ABL1 APC CEBPA EDIL3 ETV6 PBX1
6 hematopoietic system MP:0005397 10.08 ABL1 APC CEBPA EDIL3 ETV6 PBX1
7 embryo MP:0005380 10.07 ABL1 APC EDIL3 ETV6 PBX1 RET
8 immune system MP:0005387 10.03 ABL1 APC CEBPA EDIL3 ETV6 PBX1
9 mortality/aging MP:0010768 10.02 ABL1 APC CEBPA EDIL3 ETV6 FARSA
10 liver/biliary system MP:0005370 9.85 ABL1 APC CEBPA EDIL3 PBX1 TCF3
11 limbs/digits/tail MP:0005371 9.8 APC EDIL3 PBX1 RET TCF3
12 muscle MP:0005369 9.73 ABL1 APC CEBPA EDIL3 PBX1 RET
13 normal MP:0002873 9.56 ABL1 APC CEBPA EDIL3 ETV6 PBX1
14 neoplasm MP:0002006 9.55 APC CEBPA ETV6 RET TCF3
15 renal/urinary system MP:0005367 9.1 APC CEBPA EDIL3 PBX1 RET TCF3

Drugs & Therapeutics for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Search Clinical Trials , NIH Clinical Center for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Genetic Tests for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Anatomical Context for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

MalaCards organs/tissues related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

40
B Lymphoblasts

Publications for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Variations for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

ClinVar genetic disease variations for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CEBPA NM_004364.4(CEBPA):c.667G>A (p.Gly223Ser)SNV Conflicting interpretations of pathogenicity 239926 rs535980233 19:33792654-33792654 19:33301748-33301748
2 APC NM_000038.6(APC):c.296G>A (p.Arg99Gln)SNV Uncertain significance 181832 rs199842850 5:112102961-112102961 5:112767264-112767264
3 SDHA NM_004168.4(SDHA):c.287C>T (p.Thr96Ile)SNV Uncertain significance 239666 rs377620054 5:224611-224611 5:224496-224496
4 RET NM_020975.6(RET):c.200G>A (p.Arg67His)SNV Benign/Likely benign 41839 rs192489011 10:43596033-43596033 10:43100585-43100585

Expression for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Search GEO for disease gene expression data for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy.

Pathways for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Pathways related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 TCF3 RET PBX1 IL3 CEBPA ABL1
2
Show member pathways
12.3 RET IL3 CEBPA APC ABL1
3 12.08 RET IL3 CEBPA APC ABL1
4 12.07 TCF3 PBX1 IL3 CEBPA
5 11.71 TCF3 RET PBX1
6 11.3 TCF3 PBX1 IL3 ETV6 CEBPA
7 10.75 TCF3 APC

GO Terms for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Cellular components related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.8 TCF3 PBX1 CEBPA

Biological processes related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 TCF3 PBX1 ETV6 CEBPA ABL1
2 regulation of cell proliferation GO:0042127 9.54 PBX1 CEBPA ABL1
3 nervous system development GO:0007399 9.46 TCF3 SDHA RET IL3
4 spleen development GO:0048536 9.32 PBX1 ABL1
5 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.26 CEBPA APC
6 positive regulation of muscle cell differentiation GO:0051149 8.96 TCF3 ABL1
7 embryonic hemopoiesis GO:0035162 8.62 PBX1 IL3

Sources for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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