MCID: BLY006
MIFTS: 31

B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

MalaCards integrated aliases for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

Name: B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy 12 58 15
B Lymphoblastic Leukemia/lymphoma with Hypodiploidy 6
B-All with Hypodiploidy 12
Hypodiploid All 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

Disease Ontology 12 DOID:0080647
NCIt 50 C80338
Orphanet 58 ORPHA585942

Summaries for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Disease Ontology : 12 A B-lymphoblastic leukemia/lymphoma that is composed of B-lymphoblasts which contain less than 46 chromosomes.

MalaCards based summary : B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy, also known as b lymphoblastic leukemia/lymphoma with hypodiploidy, is related to b-lymphoblastic leukemia/lymphoma with hyperdiploidy and extra-adrenal pheochromocytoma. An important gene associated with B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are Developmental Biology and Endometrial cancer. Affiliated tissues include b lymphoblasts, liver and testis, and related phenotypes are embryo and digestive/alimentary

Related Diseases for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Diseases related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.2 PBX1 APC
2 extra-adrenal pheochromocytoma 10.2 SDHA RET
3 pheochromocytoma-paraganglioma 10.2 SDHA RET
4 esophagus leiomyoma 10.2 SDHA RET
5 adrenal medulla cancer 10.1 SDHA RET
6 persistent generalized lymphadenopathy 10.1 SDHA RET
7 paraganglioma and gastric stromal sarcoma 10.1 SDHA RET
8 lymph node disease 10.1 SDHA RET
9 cerebellar angioblastoma 10.1 SDHA ETV6
10 mental retardation, autosomal dominant 29 10.1 PBX1 ABL1
11 acinar cell carcinoma 10.1 ETV6 APC
12 b-cell adult acute lymphocytic leukemia 10.1 PBX1 ABL1
13 multiple endocrine neoplasia, type iia 10.1 SDHA RET
14 cardiovascular organ benign neoplasm 10.0 RET APC
15 pilocytic astrocytoma 10.0 SDHA RET APC
16 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.0 ETV6 ABL1
17 testicular leukemia 10.0 ETV6 ABL1
18 parathyroid carcinoma 10.0 RET APC
19 oropharynx cancer 10.0 ETV6 APC
20 alveolar soft part sarcoma 10.0 TCF3 RET APC
21 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.0 SDHA RET APC
22 myelodysplastic/myeloproliferative neoplasm 10.0 ETV6 ABL1
23 atypical chronic myeloid leukemia 9.9 ETV6 ABL1
24 chronic eosinophilic leukemia 9.9 ETV6 ABL1
25 differentiated thyroid carcinoma 9.8 RET ETV6
26 gastrointestinal stromal tumor 9.8 SDHA APC ABL1
27 b-lymphoblastic leukemia/lymphoma with iamp21 9.8 PBX1 ETV6 ABL1
28 childhood acute lymphocytic leukemia 9.8 PBX1 ETV6 ABL1
29 polycythemia vera 9.6 IL3 ETV6 ABL1
30 myeloproliferative neoplasm 9.6 IL3 ETV6 ABL1
31 mental retardation, autosomal dominant 33 9.6 IGHV4-38-2 ETV6 ABL1
32 leukemia, acute lymphoblastic 3 9.6 TCF3 PBX1 ETV6 ABL1
33 adult acute lymphocytic leukemia 9.6 TCF3 PBX1 ETV6 ABL1
34 childhood leukemia 9.6 TCF3 PBX1 ETV6 ABL1
35 bone marrow cancer 9.5 IL3 IGHV4-38-2 ABL1
36 hematologic cancer 9.5 IL3 ETV6 APC ABL1
37 acute leukemia 9.5 TCF3 PBX1 IL3 ETV6
38 myeloma, multiple 9.4 TCF3 IL3 IGHV4-38-2
39 lymphoma, non-hodgkin, familial 9.3 IL3 IGHV4-38-2 ETV6 APC
40 leukemia, chronic myeloid 9.3 IL3 ETV6 ABL1
41 leukemia 9.2 TCF3 PBX1 IL3 ETV6 ABL1
42 b-lymphoblastic leukemia/lymphoma 9.0 TCF3 RET PBX1 IL3 ETV6 ABL1
43 leukemia, acute myeloid 8.8 TCF3 PBX1 IL3 IGHV4-38-2 ETV6 ABL1
44 leukemia, acute lymphoblastic 8.6 TCF3 PBX1 IL3 IGHV4-38-2 ETV6 APC

Graphical network of the top 20 diseases related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:



Diseases related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Symptoms & Phenotypes for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

MGI Mouse Phenotypes related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.73 ABL1 APC ETV6 PBX1 RET TCF3
2 digestive/alimentary MP:0005381 9.72 ABL1 APC ETV6 PBX1 RET
3 endocrine/exocrine gland MP:0005379 9.63 ABL1 APC ETV6 PBX1 RET TCF3
4 liver/biliary system MP:0005370 9.35 ABL1 APC ETV6 PBX1 TCF3
5 normal MP:0002873 9.1 ABL1 APC ETV6 PBX1 RET TCF3

Drugs & Therapeutics for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Search Clinical Trials , NIH Clinical Center for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Genetic Tests for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Anatomical Context for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

MalaCards organs/tissues related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

40
B Lymphoblasts, Liver, Testis

Publications for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Articles related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

(show all 24)
# Title Authors PMID Year
1
Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL. 61
32881995 2021
2
Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia. 61
33095873 2020
3
Nationwide survey of pediatric hypodiploid acute lymphoblastic leukemia in Japan. 61
31519067 2019
4
Hematopoietic Stem-Cell Transplantation Does Not Improve the Poor Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Report From Children's Oncology Group. 61
30742559 2019
5
Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia: A Retrospective Multinational Study. 61
30657737 2019
6
Mesenchymal Stem Cell Therapy Overcomes Steroid Resistance in Severe Gastrointestinal Acute Graft-Versus-Host Disease. 61
31263624 2019
7
Genomics and pharmacogenomics of pediatric acute lymphoblastic leukemia. 61
29759551 2018
8
TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children. 61
29300620 2018
9
TP53 Mutations in Hypodiploid Acute Lymphoblastic Leukemia. 61
28003275 2017
10
Near-haploid and low-hypodiploid acute lymphoblastic leukemia: two distinct subtypes with consistently poor prognosis. 61
27903530 2017
11
Genetic and epigenetic characterization of hypodiploid acute lymphoblastic leukemia. 61
26544893 2015
12
Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels. 61
26527677 2015
13
Transplantation Outcomes for Children with Hypodiploid Acute Lymphoblastic Leukemia. 61
25865650 2015
14
The genomic landscape of hypodiploid acute lymphoblastic leukemia. 61
23334668 2013
15
Role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of pediatric acute lymphoblastic leukemia: update of the 2005 evidence-based review. 61
22209888 2012
16
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. 61
19129520 2009
17
Large cell calcifying Sertoli cell tumour of the testis. 61
7541015 1995
18
Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. 61
2207320 1990
19
Established mouse liver cell lines as a model system for studying epithelio-mesenchymal interactions in morphogenesis. 61
2386886 1990
20
Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line. 61
2306521 1990
21
Hypodiploidy is associated with a poor prognosis in childhood acute lymphoblastic leukemia. 61
3474042 1987
22
Transformation of human choroid cells in vitro by SV40. Ultrastructural and cytogenetic analysis of cloned cell lines. 61
6088782 1984
23
Amplified KpnL repetitive DNA sequences in homogeneously staining regions of a human melanoma cell line. 61
6200639 1984
24
Nonrandom chromosomal changes in transitional cell carcinoma of the bladder. 61
6692407 1984

Variations for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

ClinVar genetic disease variations for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 APC NM_000038.6(APC):c.296G>A (p.Arg99Gln) SNV Uncertain significance 181832 rs199842850 5:112102961-112102961 5:112767264-112767264
2 RET NM_020975.6(RET):c.200G>A (p.Arg67His) SNV Uncertain significance 41839 rs192489011 10:43596033-43596033 10:43100585-43100585
3 SDHA NM_004168.4(SDHA):c.287C>T (p.Thr96Ile) SNV Uncertain significance 239666 rs377620054 5:224611-224611 5:224496-224496

Expression for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Search GEO for disease gene expression data for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy.

Pathways for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Pathways related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 TCF3 RET PBX1 IL3 ABL1
2
Show member pathways
12.3 RET IL3 APC ABL1
3 12.18 RET IL3 APC ABL1
4 12.12 TCF3 PBX1 IL3
5 11.34 TCF3 RET PBX1
6
Show member pathways
11.22 TCF3 ABL1
7 11.21 TCF3 PBX1 IL3 ETV6
8 11.13 TCF3 APC
9 10.7 TCF3 APC

GO Terms for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

Biological processes related to B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell adhesion GO:0030155 9.37 RET ABL1
2 thymus development GO:0048538 9.32 PBX1 ABL1
3 spleen development GO:0048536 9.26 PBX1 ABL1
4 positive regulation of muscle cell differentiation GO:0051149 9.16 TCF3 ABL1
5 nervous system development GO:0007399 9.02 TCF3 SDHA RET IL3 APC
6 embryonic hemopoiesis GO:0035162 8.96 PBX1 IL3

Sources for B-Lymphoblastic Leukemia/lymphoma with Hypodiploidy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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