Babesiosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

CDC: ² Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.Although many people who are infected with Babesia do not have symptoms, for those who do effective treatment is available. Babesiosis is preventable, if simple steps are taken to reduce exposure to ticks. Babesia microti is transmitted by the bite of infected Ixodes scapularis ticks-typically, by the nymph stage of the tick, which is about the size of a poppy seed. An Ixodes scapularis nymph is shown on the face of a penny. (Credit: G. Hickling, University of Tennessee)

MalaCards based summary: Babesiosis, also known as infection by babesia, is related to tick infestation and ehrlichiosis, and has symptoms including mild fevers and anemia described as malaria-like symptoms. An important gene associated with Babesiosis is HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4), and among its related pathways/superpathways are Metabolism and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include heart, whole blood and salivary gland, and related phenotypes are fever and hemolytic anemia

GARD: ¹⁹ Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells. Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, Babesiosis may be associated with hemolytic anemia. Babesia parasites are primarily spread by infected ticks.

Disease Ontology: ¹¹ A parasitic protozoa infectious disease that has symptom mild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

Orphanet: ⁵⁸ Babesiosis is an infectious disease caused by protozoa of the genus Babesia and characterized by a febrile illness and hemolytic anemia but with manifestations ranging from an asymptomatic infection to a fulminating illness that can result in death.

Wikipedia: ⁷⁵ Babesiosis or piroplasmosis is a malaria-like parasitic disease caused by infection with a eukaryotic... more...

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Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 524)

#	Related Disease	Score	Top Affiliating Genes
1	tick infestation	31.5	MT-CYB MT-CO1 HSPD1 CD4 ALB
2	ehrlichiosis	30.8	HSPD1 GPT CD4
3	splenic infarction	30.6	HP GPT ALB
4	acute kidney failure	30.6	HP GPT ALB
5	plasmodium falciparum malaria	30.5	TNF HP CD36
6	deficiency anemia	30.5	TNF HP GPT CD4 ALB
7	theileriasis	30.4	RPS8 MT-CYB MT-CO1 HSPD1
8	pancytopenia	30.3	HP GPT CD4 ALB
9	fascioliasis	30.2	MT-CO1 GPT ALB
10	cystoisosporiasis	30.2	MT-CO1 CD4
11	hemosiderosis	30.1	HP GPT ALB
12	bartonellosis	30.1	MT-CYB MT-CO1 HSPD1 CD4
13	thrombocytopenia	30.1	TNF THBS1 HP GPT CD4 CD36
14	hemophagocytic lymphohistiocytosis	30.0	TNF GPT CD4
15	thrombotic thrombocytopenic purpura	30.0	THBS1 HP CD36 ADAMTSL1
16	rocky mountain spotted fever	30.0	HSPD1 GPT CD4
17	respiratory failure	29.9	TNF GPT CD4 ALB
18	acute kidney tubular necrosis	29.9	TNF GPT ALB
19	cholecystitis	29.9	HP GPT ALB
20	hypersensitivity reaction type iii disease	29.9	TNF CD4 ALB
21	henoch-schoenlein purpura	29.9	TNF CD4 ALB
22	west nile encephalitis	29.9	TNF CD4 ALB
23	leishmaniasis	29.8	TNF HSPA4 GPT ALB
24	spotted fever	29.8	MT-CO1 HSPD1 GPT CD4
25	autoimmune lymphoproliferative syndrome	29.8	TNF MT-CYB MT-CO1 CD4
26	plague	29.8	TNF MT-CYB CD4 ALB
27	acalculous cholecystitis	29.8	GPT CD4 ALB
28	relapsing fever	29.8	TNF MT-CYB HSPD1
29	sickle cell anemia	29.8	TNF HP CD4 CD36 ALB
30	filarial elephantiasis	29.7	TNF MT-CO1 CD4
31	reactive arthritis	29.7	TNF HSPD1 HP
32	hypersensitivity vasculitis	29.7	TNF CD4 ALB
33	peptic ulcer disease	29.7	TNF GPT ALB
34	gilbert syndrome	29.7	HP GPT ALB
35	bilirubin metabolic disorder	29.7	TNF PRODH HP GPT CD4 ALB
36	interstitial nephritis	29.7	TNF CD4 ALB
37	tularemia	29.6	TNF HSPD1 CD4
38	chagas disease	29.6	TNF HSPA4 CD4
39	parkinson disease, late-onset	29.6	PRODH MT-CYB HSPD1 HSPA4 COQ2 ALB
40	trypanosomiasis	29.6	TNF PRODH MT-CYB HP GPT CD4
41	filariasis	29.6	TNF MT-CO1 CD4 ALB
42	crohn's disease	29.5	TNF HP CD4 ALB
43	urethritis	29.5	TNF HSPD1 CD4 ALB
44	pericardial effusion	29.4	TNF GPT CD4 ALB
45	exanthem	29.4	TNF GPT CD4 ALB
46	dengue disease	29.4	TNF GPT CD4 ALB
47	glucosephosphate dehydrogenase deficiency	29.4	TNF PRODH HP GPT ALB
48	coccidiosis	29.4	TNF MT-CYB HSPA4 GPT CD4 ALB
49	arthritis	29.4	TNF HSPD1 HSPA4 GPT ALB
50	celiac disease 1	29.3	TNF HP GPT CD4 ALB

Graphical network of the top 20 diseases related to Babesiosis:

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Symptoms & Phenotypes for Babesiosis

Human phenotypes related to Babesiosis:

⁵⁸ ³⁰ (show all 31)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	fever ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001945
2	hemolytic anemia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0001878
3	headache ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002315
4	hyperhidrosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000975
5	splenomegaly ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001744
6	hepatomegaly ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002240
7	fatigue ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012378
8	thrombocytopenia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001873
9	jaundice ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000952
10	arthralgia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002829
11	myalgia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003326
12	cough ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0012735
13	leukopenia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001882
14	nausea and vomiting ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002017
15	depression ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000716
16	respiratory insufficiency ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002093
17	photophobia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000613
18	renal insufficiency ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000083
19	congestive heart failure ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001635
20	myocardial infarction ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001658
21	venous thrombosis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0004936
22	anorexia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002039
23	recurrent pharyngitis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100776
24	hepatic failure ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001399
25	limitation of joint mobility ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001376
26	coma ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001259
27	confusion ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001289
28	clinodactyly of the 5th toe ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001864
29	disseminated intravascular coagulation ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0005521
30	hypercoagulability ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100724
31	recurrent infections ⁵⁸		Frequent (79-30%)

Symptoms:

¹¹

• mild fevers

• anemia described as malaria-like symptoms

Sources

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Immunoglobulins		Phase 3
2	Antibodies		Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Blood Donation Screening for Babesia Microti by Real-time Polymerase Chain Reaction (PCR) and by Indirect Flourescent Antibody (IFA) Assays	Completed	NCT01528449	Phase 3
2	Description of Case of Infection With a New Species of Babesia and Its Molecular Diagnosis	Recruiting	NCT04960995

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Quinine

QUININE SO4 PWDR

Quinine Sulfate

Cochrane evidence based reviews: babesiosis

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Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

Organs/tissues related to Babesiosis:

MalaCards : Heart, Whole Blood, Salivary Gland, Spleen, Bone Marrow, Kidney, T Cells

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Publications for Babesiosis

Articles related to Babesiosis:

(show top 50) (show all 3403)

#	Title	Authors	PMID	Year
1	Serum and urine profiling by high-throughput TMT-based proteomics for the investigation of renal dysfunction in canine babesiosis. ⁶²	Bilic P...Mrljak V	36174949	2023
2	Animal models of the immunology and pathogenesis of human babesiosis. ⁶²	Kumar A...Krause PJ	36470781	2022
3	Economic impact of predominant ticks and tick-borne diseases on Indian dairy production systems. ⁶²	Singh K...Ghosh S	36336025	2022
4	Nested qPCR assay to detect Babesia duncani infection in hamsters and humans. ⁶²	Wang Y...Guan G	36192649	2022
5	Predicting the potential distribution of the cattle fever tick Rhipicephalus annulatus (Acari: Ixodidae) using ecological niche modeling. ⁶²	Okely M...Al-Khalaf AA	36136139	2022
6	Prevalence and phylogenetic analysis of Babesia parasites in reservoir host species in Fujian province, Southeast China. ⁶²	Zeng Z...Xiao F	35819239	2022
7	Prevalence of Babesia spp. pathogens in the ticks Dermacentor reticulatus and Ixodes ricinus in the UK. ⁶²	Sands B...Wall R	36115381	2022
8	Splenic diffuse heterogeneous hypoechogenicity pattern of dogs and cats: A systematic review. ⁶²	Fontoura-Andrade JL	35933802	2022
9	First Report of Babesia gibsoni in Cats in China. ⁶²	Yin F...Li F	36428294	2022
10	Babesia in North America: An Update. ⁶²	Dear JD...Birkenheuer A	36336417	2022
11	Deployment of a reservoir-targeted vaccine against Borreliella burgdorferi reduces the prevalence of Babesia microti coinfection in Ixodes scapularis ticks. ⁶²	Vannier E...Gomes-Solecki M	36416014	2022
12	First report of canine rangeliosis in domestic dogs from different regions of Santa Catarina State, Brazil. ⁶²	Rodrigues RG...de Moura AB	36436892	2022
13	Comparing the Epidemiology and Health Burden of Lyme Disease and Babesiosis Hospitalizations in the United States. ⁶²	Bloch EM...Tobian AAR	36467296	2022
14	Theileria equi in the horses of Iran: Molecular detection, genetic diversity, and hematological findings. ⁶²	Kalantari M...Nazifi S	36436901	2022
15	Thrombospondin-Related Anonymous Protein (TRAP) Family Expression by Babesia bovis Life Stages within the Mammalian Host and Tick Vector. ⁶²	Masterson HE...Ueti MW	36363765	2022
16	The First Records of Canine Babesiosis in Dogs from Dermacentor reticulatus-Free Zone in Poland. ⁶²	Pawelczyk O...Solarz K	36422581	2022
17	Successful treatment of babesiosis in a south-western black rhinoceros(Diceros bicornis bicornis). ⁶²	Zimmermann DE...Penzhorn BL	35934911	2022
18	The presence of malignant ovine babesiosis in Bosnia and Herzegovina indicates a possible emerging risk for Balkan region. ⁶²	Stevanovic O...Ilic T	36240662	2022
19	Sensitive and rapid detection of Babesia species in dogs by recombinase polymerase amplification with lateral flow dipstick (RPA-LFD). ⁶²	Onchan W...Buddhachat K	36446883	2022
20	Genetic diversity in Babesia bovis from southern Africa and estimation of B. bovis infection levels in cattle using an optimised quantitative PCR assay. ⁶²	Byaruhanga C...Collins NE	36427476	2022
21	A vaccine for human babesiosis: prospects and feasibility. ⁶²	Al-Nazal H...Stanisic DI	35933301	2022
22	Procalcitonin as a Potential Biomarker in the Study of Babesiosis Caused by B. microti. ⁶²	Lum M...Marcos LA	36364974	2022
23	Periviscerokinin (Cap2b; CAPA) receptor silencing in females of Rhipicephalus microplus reduces survival, weight and reproductive output. ⁶²	Wulff JP...Pietrantonio PV	36203198	2022
24	Novel equi merozoite antigen (ema-1) gene heterogeneity in a geographically isolated Theileria equi population in Croatia. ⁶²	Coultous R...Shiels B	36316753	2022
25	Delivery and effectiveness of entomopathogenic fungi for mosquito and tick control: Current knowledge and research challenges. ⁶²	Cafarchia C...Otranto D	35914564	2022
26	Molecular Epidemiological Investigation of Piroplasms and Anaplasmataceae Bacteria in Egyptian Domestic Animals and Associated Ticks. ⁶²	Abdel-Shafy S...Abdel-Rahman EH	36297251	2022
27	A novel promising diagnostic candidate selected by screening the transcriptome of Babesia gibsoni (Wuhan isolate) asexual stages in infected beagles. ⁶²	Guo J...He L	36217160	2022
28	Seasonal fluctuations of Babesia bigemina and Rhipicephalus microplus in Brangus and Nellore cattle reared in the Cerrado biome, Brazil. ⁶²	Martins KR...Andreotti R	36307861	2022
29	Molecular epidemiology and characterization of Babesia bovis in cattle of Khyber Pakhtunkhwa province, Pakistan. ⁶²	Shoaib M...Khan R	36208348	2022
30	Failure of an Approximately Six Week Course of Tafenoquine to Completely Eradicate Babesia microti Infection in an Immunocompromised Patient. ⁶²	Prasad PJ...Wormser GP	36145484	2022
31	Repurposing of the Malaria Box for Babesia microti in mice identifies novel active scaffolds against piroplasmosis. ⁶²	Rizk MA...Igarashi I	36123705	2022
32	Incidences of Rhipicephalus (Boophilus) microplus (Canestrini, 1888) Transmitted Pathogens in Cattle in West Africa. ⁶²	Toure A...Sahibi H	35713759	2022
33	Eco-epidemiology of equine piroplasmosis and its associated tick vectors in Europe: A systematic literature review and a meta-analysis of prevalence. ⁶²	Nadal C...Marsot M	34333863	2022
34	High genetic diversity of Babesia canis (Piana & Galli-Valerio, 1895) in a recent local outbreak in Berlin/ Brandenburg, Germany. ⁶²	Helm CS...Krucken J	35689449	2022
35	Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo. ⁶²	Pal AC...Ben Mamoun C	35512141	2022
36	First Molecular Identification of Babesia, Theileria, and Anaplasma in Goats from the Philippines. ⁶²	Galon EM...Xuan X	36297166	2022
37	Development of a duplex real-time PCR assay for simultaneous detection and differentiation of Theileria equi and Babesia caballi. ⁶²	Chen K...Wang X	35089645	2022
38	In vivo activity and atom pair fingerprint analysis of MMV665941 against the apicomplexan parasite Babesia microti, the causative agent of babesiosis in humans and rodents. ⁶²	Rizk MA...Igarashi I	36172647	2022
39	A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice. ⁶²	Montenegro VN...Wilkowsky SE	35792436	2022
40	Clinical and Hematologic Findings in Babesia canis Infection in Eastern Slovakia. ⁶²	Turna H...Svoboda M	35831668	2022
41	Efficacy of the Antimalarial MMV390048 against Babesia Infection Reveals Phosphatidylinositol 4-Kinase as a Druggable Target for Babesiosis. ⁶²	Ji S...Xuan X	35924942	2022
42	High Asymptomatic Cases of Babesiosis in Dogs and Comparison of Diagnostic Performance of Conventional PCR vs Blood Smears. ⁶²	Ranatunga RAS...Rajakaruna RS	35612719	2022
43	Human Babesiosis. ⁶²	Waked R...Krause PJ	36116841	2022
44	Propagation of Babesia bigemina in Rabbit Model and Evaluation of Its Attenuation in Cross-Bred Calves. ⁶²	Ullah N...Rashid MI	36078007	2022
45	Specific and Sensitive Diagnosis of Babesia microti Active Infection Using Monoclonal Antibodies to the Immunodominant Antigen BmGPI12. ⁶²	Gagnon J...Ledizet M	36040206	2022
46	Elucidating Parasite and Host Cell Factors Enabling Babesia Infection in Sickle Red Cells under Hypoxic/Hyperoxic Conditions. ⁶²	Beri D...Lobo CA	35977077	2022
47	Molecular Reports of Ruminant Babesia in Southeast Asia. ⁶²	Galon EM...Xuan X	36015035	2022
48	Bovine babesiosis in India: Estimation of prevalence by systematic review and meta analysis. ⁶²	Jacob SS...Shome BR	35779644	2022
49	Correction: Kumar et al. The Global Emergence of Human Babesiosis. Pathogens 2021, 10, 1447. ⁶²	Kumar A...Krause PJ	36015072	2022
50	Extraordinary high level of propagation of Babesia divergens in severe human babesiosis. ⁶²	Kukina IV...Zelya OP	35591780	2022

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Genes for Babesiosis

Genes related to Babesiosis (0 elite genes):

(show all 24)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	12.46	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	CD36	CD36 Molecule	Protein Coding	10.69	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	ADAMTSL1	ADAMTS Like 1	Protein Coding	7.39	GeneCards inferred via : Publications (show sections)
4	THBS1	Thrombospondin 1	Protein Coding	7.39	GeneCards inferred via : Publications (show sections)
5	MT-CYB	Mitochondrially Encoded Cytochrome B	Protein Coding	7.3	DISEASES inferred ¹⁴
6	PRODH	Proline Dehydrogenase 1	Protein Coding	6.78	DISEASES inferred ¹⁴ ¹⁴
7	MT-CO1	Mitochondrially Encoded Cytochrome C Oxidase I	Protein Coding	6.34	DISEASES inferred ¹⁴
8	CCT7	Chaperonin Containing TCP1 Subunit 7	Protein Coding	6.29	DISEASES inferred ¹⁴
9	HP	Haptoglobin	Protein Coding	6.19	DISEASES inferred ¹⁴
10	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	6.11	DISEASES inferred ¹⁴
11	RPL4	Ribosomal Protein L4	Protein Coding	5.99	DISEASES inferred ¹⁴
12	CRYGD	Crystallin Gamma D	Protein Coding	5.78	DISEASES inferred ¹⁴
13	ALB	Albumin	Protein Coding	5.76	DISEASES inferred ¹⁴
14	SECISBP2	SECIS Binding Protein 2	Protein Coding	5.71	DISEASES inferred ¹⁴
15	RPS8	Ribosomal Protein S8	Protein Coding	5.66	DISEASES inferred ¹⁴
16	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	5.61	DISEASES inferred ¹⁴
17	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	5.61	DISEASES inferred ¹⁴
18	CD4	CD4 Molecule	Protein Coding	5.54	DISEASES inferred ¹⁴
19	COQ2	Coenzyme Q2, Polyprenyltransferase	Protein Coding	5.5	DISEASES inferred ¹⁴
20	TNF	Tumor Necrosis Factor	Protein Coding	5.4	DISEASES inferred ¹⁴
21	IL10	Interleukin 10	Protein Coding	5.36	DISEASES inferred ¹⁴
22	MASP1	MBL Associated Serine Protease 1	Protein Coding	5.35	DISEASES inferred ¹⁴
23	CRP	C-Reactive Protein	Protein Coding	5.29	DISEASES inferred ¹⁴
24	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	5.23	DISEASES inferred ¹⁴

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Variations for Babesiosis

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Expression for Babesiosis

Search GEO for disease gene expression data for Babesiosis.

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Pathways for Babesiosis

Pathways related to Babesiosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism ⁶⁶ Show member pathways Metabolism of lipids ⁶⁶	12.78	SECISBP2 RPS8 RPL4 RAP1A PRODH MT-CYB
2	Binding and Uptake of Ligands by Scavenger Receptors ⁶⁶ Show member pathways Scavenging by Class A Receptors ⁶⁶ Scavenging by Class B Receptors ⁶⁶ Scavenging by Class F Receptors ⁶⁶ Scavenging by Class H Receptors ⁶⁶ Scavenging of heme from plasma ⁶⁶	11.29	HP CD36 ALB
3	Apoptosis-related network due to altered Notch3 in ovarian cancer ⁷⁴	10.85	TNF THBS1 HSPD1

Sources

GO Terms for Babesiosis

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell death	GO:0010942	9.43	PRODH HP CD36
2	positive regulation of blood microparticle formation	GO:2000334	8.92	TNF CD36

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ATP-dependent protein folding chaperone	GO:0140662	9.1	HSPD1 HSPA4 CCT7

Sources

Sources for Babesiosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: BBS001 MIFTS: 48	Babesiosis Categories: Blood diseases, Infectious diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Babesiosis

Aliases & Classifications for Babesiosis

MalaCards integrated aliases for Babesiosis:

Characteristics:

Age Of Onset:

Classifications:

External Ids:

Summaries for Babesiosis

Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Babesiosis:

Symptoms & Phenotypes for Babesiosis

Human phenotypes related to Babesiosis:

Symptoms:

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

Anatomical Context for Babesiosis

Organs/tissues related to Babesiosis:

Publications for Babesiosis

Articles related to Babesiosis:

Genes for Babesiosis

Genes related to Babesiosis (0 elite genes):

Variations for Babesiosis

Expression for Babesiosis

Pathways for Babesiosis

Pathways related to Babesiosis according to GeneCards Suite gene sharing:

GO Terms for Babesiosis

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

Sources for Babesiosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :