MCID: BBS001
MIFTS: 48

Babesiosis

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Babesiosis

MalaCards integrated aliases for Babesiosis:

Name: Babesiosis 12 74 52 58 3 3 43 15 17 71 32
Human Babesiosis 52 71
Babesia Parasite Infection 52
Infection by Babesia 12
Piroplasmosis 12
Babesiasis 12

Characteristics:

Orphanet epidemiological data:

58
babesiosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Babesiosis

CDC : 3 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.Although many people who are infected with Babesia do not have symptoms, for those who do effective treatment is available. Babesiosis is preventable, if simple steps are taken to reduce exposure to ticks. Babesia microti is transmitted by the bite of infected Ixodes scapularis ticks-typically, by the nymph stage of the tick, which is about the size of a poppy seed. An Ixodes scapularis nymph is shown on the face of a penny. (Credit: G. Hickling, University of Tennessee)

MalaCards based summary : Babesiosis, also known as human babesiosis, is related to tick infestation and acute kidney failure, and has symptoms including mild fevers and anemia described as malaria-like symptoms. An important gene associated with Babesiosis is HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4), and among its related pathways/superpathways is Malaria. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, spleen and heart, and related phenotypes are fever and hemolytic anemia

Disease Ontology : 12 A parasitic protozoa infectious disease that has symptom mild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

NIH Rare Diseases : 52 Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells . Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, babesiosis can be associated with hemolytic anemia . Babesia parasites are primarily spread by infected ticks. Treatment is generally only required in people who develop symptoms of the condition. When necessary, affected people are often prescribed a combination of antimicrobial medications along with supportive care to manage symptoms.

Wikipedia : 74 Babesiosis is a malaria-like parasitic disease caused by infection with the eukaryotic parasite Babesia,... more...

Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 345)
# Related Disease Score Top Affiliating Genes
1 tick infestation 32.7 MT-CO1 HUWE1 CD4
2 acute kidney failure 30.7 HP GPT ALB
3 thrombocytopenia 30.7 THBS1 HP GPT CD40LG ALB
4 anemia, autoimmune hemolytic 30.6 HP CD40LG CD4
5 theileriasis 30.6 RPS8 PARVA MT-CYB HUWE1
6 bartonellosis 30.5 MT-CYB CD40LG CD4
7 splenic infarction 30.4 HP GPT CD40LG ALB
8 fascioliasis 30.3 MT-CO1 GPT ALB
9 pancytopenia 30.3 HP CD40LG CD4 ALB
10 hellp syndrome 30.2 THBS1 HP GPT CD40LG
11 neuroretinitis 30.2 CD40LG CD4
12 bilirubin metabolic disorder 30.2 HP GPT CD40LG ALB
13 thrombotic thrombocytopenic purpura 30.2 THBS1 HP CD40LG ADAMTSL1
14 rabies 30.1 HSPA4 CD40LG ALB
15 anuria 30.1 HP GPT CD40LG ALB
16 immunoglobulin alpha deficiency 30.0 HP CD40LG CD4
17 autoimmune lymphoproliferative syndrome 30.0 MT-CYB MT-CO1 CD40LG CD4
18 respiratory failure 29.9 GPT CD40LG CD4 ALB
19 coccidiosis 29.9 MT-CYB HSPA4 CD40LG CD4 ALB
20 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 29.9 MT-CYB HUWE1 CD4 CCT7
21 plasmodium falciparum malaria 29.8 THBS1 HP CD40LG CD36 ALB
22 pericardial effusion 29.6 GPT CD40LG CD4 ALB
23 exanthem 29.6 GPT CD40LG CD4 ALB
24 celiac disease 1 29.6 HP CD40LG CD4 ALB
25 malaria 29.2 THBS1 MT-CYB HSPA4 HP GPT CD40LG
26 parasitic protozoa infectious disease 28.3 MT-CYB MT-CO1 HUWE1 HSPA4 HP GPT
27 lyme disease 10.8
28 hemolytic anemia 10.7
29 ehrlichiosis 10.6
30 plasmodium malariae malaria 10.5 MT-CYB CD40LG
31 cryofibrinogenemia 10.5 HP CD40LG
32 pediculus humanus capitis infestation 10.5 MT-CYB MT-CO1
33 kunjin encephalitis 10.5 HUWE1 CD40LG
34 phlebotomus fever 10.5 MT-CYB CD40LG
35 sarcocystosis 10.4 MT-CO1 CD40LG
36 splenomegaly 10.4
37 dysferlinopathy 10.4 THBS1 GPT
38 fournier gangrene 10.4 CD40LG ALB
39 oesophagostomiasis 10.4 MT-CYB MT-CO1
40 interstitial keratitis 10.4 CD40LG CD36
41 acanthocephaliasis 10.4 MT-CO1 ALB
42 sparganosis 10.4 MT-CYB MT-CO1
43 non-secretory myeloma 10.4 CD40LG ALB
44 nutmeg liver 10.4 HP GPT
45 human granulocytic anaplasmosis 10.4
46 trimethoprim allergy 10.4 HP GPT
47 hemoglobinuria 10.4
48 posttransplant acute limbic encephalitis 10.4
49 american histoplasmosis 10.3 CD40LG CD4
50 syphilitic meningitis 10.3 CD40LG CD4

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to Babesiosis

Symptoms & Phenotypes for Babesiosis

Human phenotypes related to Babesiosis:

58 31 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 hemolytic anemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001878
3 headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0002315
4 splenomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001744
5 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
6 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
7 hyperhidrosis 58 31 frequent (33%) Frequent (79-30%) HP:0000975
8 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
9 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
10 cough 58 31 frequent (33%) Frequent (79-30%) HP:0012735
11 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
12 jaundice 58 31 frequent (33%) Frequent (79-30%) HP:0000952
13 leukopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001882
14 photophobia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000613
15 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
16 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
17 myocardial infarction 58 31 occasional (7.5%) Occasional (29-5%) HP:0001658
18 nausea and vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002017
19 depressivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000716
20 respiratory insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0002093
21 venous thrombosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004936
22 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
23 recurrent pharyngitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100776
24 hepatic failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001399
25 limitation of joint mobility 58 31 occasional (7.5%) Occasional (29-5%) HP:0001376
26 confusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0001289
27 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
28 clinodactyly of the 5th toe 58 31 occasional (7.5%) Occasional (29-5%) HP:0001864
29 disseminated intravascular coagulation 58 31 occasional (7.5%) Occasional (29-5%) HP:0005521
30 hypercoagulability 58 31 occasional (7.5%) Occasional (29-5%) HP:0100724
31 recurrent infections 58 Frequent (79-30%)

Symptoms:

12
  • mild fevers
  • anemia described as malaria-like symptoms

MGI Mouse Phenotypes related to Babesiosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.03 ALB CD36 CD4 CD40LG HP HSPA4
2 endocrine/exocrine gland MP:0005379 9.81 ALB CD36 CD4 CD40LG HSPA4 HUWE1
3 mortality/aging MP:0010768 9.77 ALB CD36 CD4 CD40LG HP HSPA4
4 renal/urinary system MP:0005367 9.23 ALB CD36 CD40LG HP HUWE1 LRPAP1

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3
3
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
4
Permethrin Approved, Investigational 52645-53-1 40326

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Blood Donation Screening for Babesia Microti by Real-time Polymerase Chain Reaction (PCR) and by Indirect Flourescent Antibody (IFA) Assays Completed NCT01528449 Phase 3
2 A School-Based Intervention to Reduce Lyme Disease Unknown status NCT00594997
3 Fever After Tick Bite (FATB) Study; Determining the Etiology of Tick-Borne Human Infections in Northern Europe Recruiting NCT03932448
4 Tick-borne Illness and Clothing Study of Rhode Island Active, not recruiting NCT02613585

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Quinine
QUININE SO4 PWDR
Quinine Sulfate

Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

Anatomical Context for Babesiosis

MalaCards organs/tissues related to Babesiosis:

40
Testes, Spleen, Heart, Kidney, B Cells, Whole Blood, Liver

Publications for Babesiosis

Articles related to Babesiosis:

(show top 50) (show all 2436)
# Title Authors PMID Year
1
Molecular epidemiological survey of Babesia bovis, Babesia bigemina, and Babesia sp. Mymensingh infections in Mongolian cattle. 61
32205192 2020
2
Identification and characterizations of a rhoptries neck protein 5 (BoRON5) in Babesia orientalis. 61
32179136 2020
3
Imported babesiosis caused by Babesia microti-A case report. 61
32249191 2020
4
Improved detection of Babesia bigemina from various geographical areas in Africa using quantitative PCR and reverse line blot hybridisation. 61
32209349 2020
5
Clinical/serological outcome in humans bitten by Babesia species positive Ixodes ricinus ticks in Sweden and on the Åland Islands. 61
32386909 2020
6
Bovine abortion, stillbirth and neonatal death associated with Babesia bovis and Anaplasma sp. infections in southern Brazil. 61
32423693 2020
7
Proteomic analysis reveals pathogen-derived biomarkers of acute babesiosis in erythrocytes, plasma, and urine of infected hamsters. 61
32435898 2020
8
Vibrational Spectroscopic Based Approach for Diagnosing Babesia bovis Infection. 61
32478508 2020
9
A Fluorescence in Situ Hybridization (FISH) Test for Diagnosing Babesiosis. 61
32517217 2020
10
Molecular Identification of a Novel Species, Babesia panickeri sp. nov., from a Naturally Infected Domestic Cat of India and Its Comparison with Canine Babesia Isolates. 61
32533416 2020
11
Genetic diversity of the ATAQ gene in Rhipicephalus microplus collected in Mexico and implications as anti-tick vaccine. 61
32572573 2020
12
An outbreak of bovine babesiosis in February, 2019, triggered by above average winter temperatures in southern England and co-infection with Babesia divergens and Anaplasma phagocytophilum. 61
32532309 2020
13
Emerging tick-borne pathogens of public health importance: a mini-review. 61
32478654 2020
14
Implementation and analysis of Babesia immunoassay testing. 61
32564041 2020
15
Climate change implications for the distribution of the babesiosis and anaplasmosis tick vector, Rhipicephalus (Boophilus) microplus. 61
32546223 2020
16
Identification of Essential Oils Including Garlic Oil and Black Pepper Oil with High Activity against Babesia duncani. 61
32545549 2020
17
Prevalence and molecular characterization of Babesia in pet dogs in Shenzhen, China. 61
32120143 2020
18
Antigen Discovery, Bioinformatics and Biological Characterization of Novel Immunodominant Babesia microti Antigens. 61
32533024 2020
19
A novel 53 kDa protein (BoP53) in Babesia orientalis poses the immunoreactivity using the infection serum. 61
32512049 2020
20
Landscape Ecology of Rhipicephalus (Boophilus) microplus (Ixodida: Ixodidae) Outbreaks in the South Texas Coastal Plain Wildlife Corridor Including Man-Made Barriers. 61
32338280 2020
21
Status of oxidative stress, trace elements, sialic acid and cholinesterase activity in cattle naturally infected with Babesia bigemina. 61
32505767 2020
22
Hematological and Biochemical Changes in Naturally Occurring Equine Piroplasmosis in Donkeys (Equus asinus) of Northwest of Iran. 61
32462264 2020
23
Detection of Ehrlichia spp. and Anaplasma phagocytophilum in whole blood specimens using a duplex real-time PCR assay on the ARIES instrument. 61
32035897 2020
24
Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy. 61
32414479 2020
25
Tickborne Diseases: Diagnosis and Management. 61
32352736 2020
26
Prevention strategies of transfusion-transmitted parasitic infections (TTPIs): Strengths and challenges of current approaches, and evaluation of the strategies implemented in Iran. 61
32149193 2020
27
Molecular Detection and Assessment of Risk Factors for Tick-Borne Diseases in Sheep and Goats from Turkey. 61
32378157 2020
28
Stochastic Model of Bovine Babesiosis with Juvenile and Adult Cattle. 61
32430584 2020
29
What is babesiosis? 61
32332496 2020
30
Management strategies for human babesiosis. 61
32268823 2020
31
Partial characterization of the voltage-gated sodium channel gene and molecular detection of permethrin resistance in Rhipicephalus annulatus (Say, 1821). 61
31917128 2020
32
Evaluation of acute kidney injury in dogs with complicated or uncomplicated Babesia rossi infection. 61
32107174 2020
33
Frequency and magnitude of seroreactivity to Babesia microti in 245 patients diagnosed by PCR in New York State. 61
32113703 2020
34
The pathology of the spleen in lethal canine babesiosis caused by Babesia rossi. 61
32119124 2020
35
Bovine babesiosis: An insight into the global perspective on the disease distribution by systematic review and meta-analysis. 61
32574977 2020
36
Case of Babesia crassa-Like Infection, Slovenia, 2014. 61
32310075 2020
37
Prevalence of protozoan parasites in small and medium mammals in Texas, USA. 61
32195108 2020
38
Imported Human Babesiosis, Singapore, 2018. 61
32023203 2020
39
Vaccine efficacy of recombinant BmVDAC on Rhipicephalus microplus fed on Babesia bigemina-infected and uninfected cattle. 61
31928853 2020
40
Use of molecular markers can help to understand the genetic diversity of Babesia bovis. 61
31881358 2020
41
Clofazimine, a promising drug for the treatment of Babesia microti infection in severely immunocompromised hosts. 61
32310272 2020
42
Molecular detection of Babesia divergens and Mycoplasma wenyonii infection in cattle from Bosnia And Herzegovina. 61
32107621 2020
43
A new piroplasmid species infecting dogs: morphological and molecular characterization and pathogeny of Babesia negevi n. sp. 61
32312309 2020
44
Prevalence and Coinfection of Three Tick-Borne Pathogens in Questing Adult Blacklegged Ticks Ixodes scapularis (Vilas County, Wisconsin). 61
32283047 2020
45
Tick-Borne Diseases in the United States. 61
32232463 2020
46
Epidemiological Study of Canine Babesiosis and Hepatozoonosis in the South of Romania. 61
32300950 2020
47
Don't let sleeping dogs lie: unravelling the identity and taxonomy of Babesia canis, Babesia rossi and Babesia vogeli. 61
32312292 2020
48
Annotation and characterization of Babesia gibsoni apicoplast genome. 61
32317011 2020
49
Lethal Effects of a Commercial Diatomaceous Earth Dust Product on Amblyomma americanum (Ixodida: Ixodidae) Larvae and Nymphs. 61
32333017 2020
50
Rapid isothermal duplex real-time recombinase polymerase amplification (RPA) assay for the diagnosis of equine piroplasmosis. 61
32139744 2020

Variations for Babesiosis

Expression for Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for Babesiosis

Pathways related to Babesiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.5 THBS1 CD40LG CD36

GO Terms for Babesiosis

Cellular components related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.36 THBS1 RPS8 RPL4 RAP1A IRF6 HUWE1
2 mitochondrial respiratory chain complex III GO:0005750 8.96 MT-CYB MT-CO1

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of blood coagulation GO:0030194 8.96 THBS1 CD36
2 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-CO1

Sources for Babesiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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