MCID: BBS001
MIFTS: 51

Babesiosis

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Babesiosis

MalaCards integrated aliases for Babesiosis:

Name: Babesiosis 12 76 53 59 3 44 15 73
Human Babesiosis 53 73
Babesia Parasite Infection 53
Infection by Babesia 12
Piroplasmosis 12
Babesiasis 12

Characteristics:

Orphanet epidemiological data:

59
babesiosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult;

Classifications:

Orphanet: 59  
Rare infectious diseases


Summaries for Babesiosis

NIH Rare Diseases : 53 Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells. Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, babesiosis can be associated with hemolytic anemia. Babesia parasites are primarily spread by infected ticks. Treatment is generally only required in people who develop symptoms of the condition. When necessary, affected people are often prescribed a combination of antimicrobial medications along with supportive care to manage symptoms.

MalaCards based summary : Babesiosis, also known as human babesiosis, is related to malaria and tick infestation, and has symptoms including mild fevers and anemia described as malaria-like symptoms. An important gene associated with Babesiosis is CCT7 (Chaperonin Containing TCP1 Subunit 7), and among its related pathways/superpathways are O-glycosylation of TSR domain-containing proteins and Malaria. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are depressivity and hyperhidrosis

Disease Ontology : 12 A parasitic protozoa infectious disease that has symptom mild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

CDC : 3  

Wikipedia : 76 Babesiosis /b�?biːzɪ�?o�?sɪs/, also known as babesiasis /bæbɪ�?zaɪ�?sɪs/, is a malaria-like parasitic... more...

Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 malaria 30.4 ADAMTSL1 CD36 MT-CYB THBS1
2 tick infestation 11.4
3 lyme disease 10.5
4 ehrlichiosis 10.5
5 human granulocytic anaplasmosis 10.2
6 trypanosomiasis 10.1
7 platelet glycoprotein iv deficiency 10.1 CD36 THBS1
8 thrombocytopenia 10.1
9 thrombotic thrombocytopenic purpura 10.1 ADAMTSL1 THBS1
10 hemolytic anemia 10.0
11 bartonellosis 10.0
12 acute respiratory distress syndrome 10.0
13 corneal neovascularization 10.0 CD36 THBS1
14 muscle disorders 10.0
15 glanders 10.0
16 myopathy 10.0
17 anemia, autoimmune hemolytic 10.0
18 sickle cell anemia 10.0
19 adult respiratory distress syndrome 10.0
20 spotted fever 10.0
21 peters-plus syndrome 9.9 ADAMTSL1 THBS1
22 multiple sclerosis 9.8
23 systemic lupus erythematosus 9.8
24 rheumatoid arthritis 9.8
25 celiac disease 1 9.8
26 aceruloplasminemia 9.8
27 infantile liver failure syndrome 1 9.8
28 acute liver failure 9.8
29 alopecia 9.8
30 arthritis 9.8
31 crohn's disease 9.8
32 hematopoietic stem cell transplantation 9.8
33 neutropenia 9.8
34 rocky mountain spotted fever 9.8
35 filariasis 9.8
36 respiratory failure 9.8
37 tick paralysis 9.8
38 chagas disease 9.8
39 filarial elephantiasis 9.8
40 pancytopenia 9.8
41 relapsing fever 9.8
42 thrombocytopenia due to platelet alloimmunization 9.8
43 splenic infarction 9.8
44 acute pancreatitis 9.8
45 myelitis 9.8
46 purpura 9.8
47 plague 9.8
48 theileriasis 9.8
49 mouth disease 9.8
50 pancreatitis 9.8

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to Babesiosis

Symptoms & Phenotypes for Babesiosis

Symptoms:

12
  • mild fevers
  • anemia described as malaria-like symptoms

Human phenotypes related to Babesiosis:

59 32 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 depressivity 59 32 occasional (7.5%) Occasional (29-5%) HP:0000716
2 hyperhidrosis 59 32 frequent (33%) Frequent (79-30%) HP:0000975
3 nausea and vomiting 59 32 occasional (7.5%) Occasional (29-5%) HP:0002017
4 respiratory insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0002093
5 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
6 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
7 renal insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0000083
8 photophobia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000613
9 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
10 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
11 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
12 hemolytic anemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001878
13 hypercoagulability 59 32 occasional (7.5%) Occasional (29-5%) HP:0100724
14 myocardial infarction 59 32 occasional (7.5%) Occasional (29-5%) HP:0001658
15 congestive heart failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001635
16 limitation of joint mobility 59 32 occasional (7.5%) Occasional (29-5%) HP:0001376
17 thrombocytopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001873
18 venous thrombosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004936
19 jaundice 59 32 frequent (33%) Frequent (79-30%) HP:0000952
20 anorexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002039
21 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
22 coma 59 32 occasional (7.5%) Occasional (29-5%) HP:0001259
23 recurrent pharyngitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100776
24 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
25 hepatic failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001399
26 headache 59 32 hallmark (90%) Very frequent (99-80%) HP:0002315
27 confusion 59 32 occasional (7.5%) Occasional (29-5%) HP:0001289
28 leukopenia 59 32 frequent (33%) Frequent (79-30%) HP:0001882
29 clinodactyly of the 5th toe 59 32 occasional (7.5%) Occasional (29-5%) HP:0001864
30 disseminated intravascular coagulation 59 32 occasional (7.5%) Occasional (29-5%) HP:0005521
31 recurrent infections 59 Frequent (79-30%)

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Babesia Testing in Blood Donors Completed NCT01528449 Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

Anatomical Context for Babesiosis

MalaCards organs/tissues related to Babesiosis:

41
Testes, Heart, Kidney, Liver, Endothelial, Pituitary, Myeloid

Publications for Babesiosis

Articles related to Babesiosis:

(show top 50) (show all 899)
# Title Authors Year
1
Retrospective study of epidemiological, clinical and pathological findings of bovine babesiosis in Mato Grosso do Sul, Brazil (1995 -2017). ( 30196016 )
2019
2
Bovine babesiosis: Cattle protected in the field with a frozen vaccine containing Babesia bovis and Babesia bigemina cultured in vitro with a serum-free medium. ( 29155165 )
2018
3
Human babesiosis, renal failure, and dialysis: A summary and comment on forgotten disease. ( 29657228 )
2018
4
Haemoparasitic agents associated with ovine babesiosis: A possible negative interaction between Babesia ovis and Theileria ovis. ( 29559137 )
2018
5
Molecular evidence for the transovarial passage of Babesia gibsoni in Haemaphysalis hystricis (Acari: Ixodidae) ticks from Taiwan: a novel vector for canine babesiosis. ( 29554924 )
2018
6
Analysis of antigen-antibody cross-reactivity among lineages and sublineages of Babesia microti parasites using human babesiosis specimens. ( 29524239 )
2018
7
Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015. ( 29383735 )
2018
8
Canine babesiosis treatment rates in South African veterinary clinics between 2011 and 2016. ( 29970141 )
2018
9
Human babesiosis in Southeast China: A case report. ( 29355731 )
2018
10
Human Babesiosis Caused by a Babesia crassa-like Pathogen: A Case Series. ( 29538646 )
2018
11
Splenic rupture from babesiosis, an emerging concern? A systematic review of current literature. ( 29954722 )
2018
12
Community-acquired and transfusion-transmitted babesiosis are increasing: why and what to do? ( 29528151 )
2018
13
Babesiosis in Essex, UK: monitoring and learning lessons from a novel disease outbreak. ( 29554939 )
2018
14
A four year epidemiological and chemotherapy survey of babesiosis and theileriosis, and tick vectors in sheep, cattle and goats in Dehgolan, Iran ( 29717573 )
2018
15
The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult. ( 29963524 )
2018
16
A Walk in the Park: A Case of Babesiosis in the South Bronx. ( 29849265 )
2018
17
Babesiosis as a cause of false-positive HIV serology. ( 29884713 )
2018
18
Human Babesiosis Caused by <i>Babesia duncani</i> Has Widespread Distribution across Canada. ( 29772759 )
2018
19
Screening of patient blood samples for babesiosis using enzymatic assays. ( 29150323 )
2018
20
Antiprotozoal treatment of canine babesiosis. ( 29657012 )
2018
21
Development of an Indirect ELISA Based on a Recombinant Chimeric Protein for the Detection of Antibodies against Bovine Babesiosis. ( 29360801 )
2018
22
Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014. ( 30016247 )
2018
23
Glomerular and tubular kidney damage markers in canine babesiosis caused by Babesia canis. ( 30057291 )
2018
24
Babesiosis and Lyme Disease in a 68-year-old man. ( 30068051 )
2018
25
Fatal human babesiosis caused by Babesia divergens in an asplenic host. ( 30073148 )
2018
26
The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development. ( 30081952 )
2018
27
A review of the history of research and control of Rhipicephalus (Boophilus) microplus, babesiosis and anaplasmosis in Uruguay. ( 30083875 )
2018
28
Response to "Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015: a response to why and what to do". ( 30133825 )
2018
29
Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015: a response to why and what to do. ( 30133827 )
2018
30
Genetic Analysis of Babesia Isolates from Cattle with Clinical Babesiosis in Sri Lanka. ( 30158190 )
2018
31
Beware of babesiosis: A rare and severe case causing death. ( 30177264 )
2018
32
Variable clinical presentations of babesiosis. ( 30234826 )
2018
33
Transfusion-transmitted babesiosis: one state's experience. ( 30260481 )
2018
34
Vectors of Babesiosis. ( 30272993 )
2018
35
Human Babesiosis, Yucatán State, Mexico, 2015. ( 30334701 )
2018
36
Notes from the Field: Reference Laboratory Investigation of Patients with Clinically Diagnosed Lyme Disease and Babesiosis - Indiana, 2016. ( 30335739 )
2018
37
Comparative evaluation of DNA extraction kit, matrix sample and qPCR assays for bovine babesiosis monitoring. ( 30362072 )
2018
38
Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease. ( 30367867 )
2018
39
Transfusion-Transmitted Babesiosis. ( 30376376 )
2018
40
Optimizing exchange transfusion for patients with severe Babesia divergens babesiosis: Therapeutically-Rational Exchange (T-REX) of M antigen-negative and/or S antigen-negative red blood cells should be evaluated now. ( 30447802 )
2018
41
LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study. ( 30485286 )
2018
42
Babesiosis-Associated Splenic Rupture: Case Series from a Hyperendemic Region. ( 30541016 )
2018
43
Splenic dysfunction from celiac disease resulting in severe babesiosis. ( 28286145 )
2017
44
Evaluation of the efficacy of sarolaner (SimparicaAr) in the prevention of babesiosis in dogs. ( 28877743 )
2017
45
Risk Factors for Severe Infection, Hospitalization, and Prolonged Antimicrobial Therapy in Patients with Babesiosis. ( 28722598 )
2017
46
Variable clinical presentations of babesiosis: A case series. ( 29040182 )
2017
47
Concurrent babesiosis and serological evidence of Lyme disease in a young patient. ( 28634526 )
2017
48
Black-backed jackals (Canis mesomelas) are natural hosts of Babesia rossi, the virulent causative agent of canine babesiosis in sub-Saharan Africa. ( 28285591 )
2017
49
Babesiosis Presenting as Acute Liver Failure. ( 29430231 )
2017
50
Babesiosis Surveillance - Wisconsin, 2001-2015. ( 28683059 )
2017

Variations for Babesiosis

Expression for Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for Babesiosis

Pathways related to Babesiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.04 ADAMTSL1 THBS1
2 10.65 CD36 THBS1
3 10.09 LRPAP1 RAP1A

GO Terms for Babesiosis

Cellular components related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phagocytic vesicle GO:0045335 8.96 CD36 RAP1A
2 integral component of mitochondrial inner membrane GO:0031305 8.62 COQ2 MT-CYB

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to calcium ion GO:0051592 9.16 MT-CYB THBS1
2 positive regulation of reactive oxygen species metabolic process GO:2000379 8.96 CD36 THBS1
3 positive regulation of blood coagulation GO:0030194 8.62 CD36 THBS1

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.16 CD36 LRPAP1
2 transforming growth factor beta binding GO:0050431 8.96 CD36 THBS1
3 low-density lipoprotein particle binding GO:0030169 8.62 CD36 THBS1

Sources for Babesiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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