MCID: BBS001
MIFTS: 52

Babesiosis

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Babesiosis

MalaCards integrated aliases for Babesiosis:

Name: Babesiosis 12 77 54 60 45 15 17 74 3
Human Babesiosis 54 74
Babesia Parasite Infection 54
Infection by Babesia 12
Piroplasmosis 12
Babesiasis 12

Characteristics:

Orphanet epidemiological data:

60
babesiosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult;

Classifications:

Orphanet: 60  
Rare infectious diseases


Summaries for Babesiosis

NIH Rare Diseases : 54 Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells. Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, babesiosis can be associated with hemolytic anemia. Babesia parasites are primarily spread by infected ticks. Treatment is generally only required in people who develop symptoms of the condition. When necessary, affected people are often prescribed a combination of antimicrobial medications along with supportive care to manage symptoms.

MalaCards based summary : Babesiosis, also known as human babesiosis, is related to malaria and tick infestation, and has symptoms including mild fevers and anemia described as malaria-like symptoms. An important gene associated with Babesiosis is CCT7 (Chaperonin Containing TCP1 Subunit 7), and among its related pathways/superpathways are Malaria and Reelin signaling pathway. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and kidney, and related phenotypes are fever and hemolytic anemia

Disease Ontology : 12 A parasitic protozoa infectious disease that has symptom mild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

CDC : 3  

Wikipedia : 77 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a type of Apicomplexa.... more...

Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 malaria 30.4 ADAMTSL1 CD36 MT-CYB THBS1
2 tick infestation 11.5
3 lyme disease 10.6
4 ehrlichiosis 10.5
5 human granulocytic anaplasmosis 10.2
6 trypanosomiasis 10.2
7 platelet glycoprotein iv deficiency 10.2 CD36 THBS1
8 thrombocytopenia 10.1
9 acute respiratory distress syndrome 10.1
10 thrombotic thrombocytopenic purpura 10.1 ADAMTSL1 THBS1
11 influenza 10.1
12 hemolytic anemia 10.1
13 bartonellosis 10.1
14 corneal neovascularization 10.0 CD36 THBS1
15 muscle disorders 10.0
16 brucellosis 10.0
17 q fever 10.0
18 glanders 10.0
19 myopathy 10.0
20 anemia, autoimmune hemolytic 10.0
21 sickle cell anemia 10.0
22 adult respiratory distress syndrome 10.0
23 spotted fever 10.0
24 splenic infarction 10.0
25 evans' syndrome 10.0
26 multiple sclerosis 9.8
27 systemic lupus erythematosus 9.8
28 rheumatoid arthritis 9.8
29 celiac disease 1 9.8
30 aceruloplasminemia 9.8
31 infantile liver failure syndrome 1 9.8
32 acute liver failure 9.8
33 alopecia 9.8
34 arthritis 9.8
35 crohn's disease 9.8
36 hematopoietic stem cell transplantation 9.8
37 leukemia 9.8
38 neutropenia 9.8
39 rocky mountain spotted fever 9.8
40 filariasis 9.8
41 respiratory failure 9.8
42 tick paralysis 9.8
43 chagas disease 9.8
44 filarial elephantiasis 9.8
45 pancytopenia 9.8
46 relapsing fever 9.8
47 thrombocytopenia due to platelet alloimmunization 9.8
48 acute pancreatitis 9.8
49 myelitis 9.8
50 purpura 9.8

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to Babesiosis

Symptoms & Phenotypes for Babesiosis

Human phenotypes related to Babesiosis:

60 33 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 hemolytic anemia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001878
3 headache 60 33 hallmark (90%) Very frequent (99-80%) HP:0002315
4 hyperhidrosis 60 33 frequent (33%) Frequent (79-30%) HP:0000975
5 splenomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0001744
6 hepatomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0002240
7 fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012378
8 arthralgia 60 33 frequent (33%) Frequent (79-30%) HP:0002829
9 thrombocytopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001873
10 jaundice 60 33 frequent (33%) Frequent (79-30%) HP:0000952
11 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
12 cough 60 33 frequent (33%) Frequent (79-30%) HP:0012735
13 leukopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001882
14 depressivity 60 33 occasional (7.5%) Occasional (29-5%) HP:0000716
15 nausea and vomiting 60 33 occasional (7.5%) Occasional (29-5%) HP:0002017
16 respiratory insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0002093
17 renal insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0000083
18 photophobia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000613
19 hypercoagulability 60 33 occasional (7.5%) Occasional (29-5%) HP:0100724
20 myocardial infarction 60 33 occasional (7.5%) Occasional (29-5%) HP:0001658
21 congestive heart failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0001635
22 limitation of joint mobility 60 33 occasional (7.5%) Occasional (29-5%) HP:0001376
23 venous thrombosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004936
24 anorexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002039
25 coma 60 33 occasional (7.5%) Occasional (29-5%) HP:0001259
26 recurrent pharyngitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100776
27 hepatic failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0001399
28 confusion 60 33 occasional (7.5%) Occasional (29-5%) HP:0001289
29 clinodactyly of the 5th toe 60 33 occasional (7.5%) Occasional (29-5%) HP:0001864
30 disseminated intravascular coagulation 60 33 occasional (7.5%) Occasional (29-5%) HP:0005521
31 recurrent infections 60 Frequent (79-30%)

Symptoms:

12
  • mild fevers
  • anemia described as malaria-like symptoms

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Babesia Testing in Blood Donors Completed NCT01528449 Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

Anatomical Context for Babesiosis

MalaCards organs/tissues related to Babesiosis:

42
Testes, Heart, Kidney, Liver, Endothelial, Pituitary, Whole Blood

Publications for Babesiosis

Articles related to Babesiosis:

(show top 50) (show all 914)
# Title Authors Year
1
Optimizing exchange transfusion for patients with severe Babesia divergens babesiosis: Therapeutically-Rational Exchange (T-REX) of M antigen-negative and/or S antigen-negative red blood cells should be evaluated now. ( 30447802 )
2019
2
Vaccination against babesiosis using recombinant GPI-anchored proteins. ( 30684517 )
2019
3
Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit? ( 30690089 )
2019
4
Human babesiosis. ( 30690090 )
2019
5
Congenital Babesiosis From Maternal Exposure: A Case Report. ( 30709608 )
2019
6
Transgenic Babesia bovis lacking 6-Cys sexual-stage genes as the foundation for non-transmissible live vaccines against bovine babesiosis. ( 30711475 )
2019
7
Splenic infarction as a rare presentation of severe babesiosis. ( 30740305 )
2019
8
Human Babesiosis in China: a systematic review. ( 30770979 )
2019
9
Inaugural meeting of the international babesiosis research community, 2018: A glimpse into the future of an emerging research field. ( 30827459 )
2019
10
Increasing Babesiosis in Southeastern Pennsylvania, 2008-2017. ( 30895205 )
2019
11
Babesiosis Masquerading as Evans Syndrome. ( 30904506 )
2019
12
A novel Babesia sp. associated with clinical signs of babesiosis in domestic cats in South Africa. ( 30909950 )
2019
13
Retrospective study of epidemiological, clinical and pathological findings of bovine babesiosis in Mato Grosso do Sul, Brazil (1995 -2017). ( 30196016 )
2019
14
Bovine babesiosis: Cattle protected in the field with a frozen vaccine containing Babesia bovis and Babesia bigemina cultured in vitro with a serum-free medium. ( 29155165 )
2018
15
Human babesiosis, renal failure, and dialysis: A summary and comment on forgotten disease. ( 29657228 )
2018
16
Haemoparasitic agents associated with ovine babesiosis: A possible negative interaction between Babesia ovis and Theileria ovis. ( 29559137 )
2018
17
Molecular evidence for the transovarial passage of Babesia gibsoni in Haemaphysalis hystricis (Acari: Ixodidae) ticks from Taiwan: a novel vector for canine babesiosis. ( 29554924 )
2018
18
Analysis of antigen-antibody cross-reactivity among lineages and sublineages of Babesia microti parasites using human babesiosis specimens. ( 29524239 )
2018
19
Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015. ( 29383735 )
2018
20
Canine babesiosis treatment rates in South African veterinary clinics between 2011 and 2016. ( 29970141 )
2018
21
Human babesiosis in Southeast China: A case report. ( 29355731 )
2018
22
Human Babesiosis Caused by a Babesia crassa-like Pathogen: A Case Series. ( 29538646 )
2018
23
Splenic rupture from babesiosis, an emerging concern? A systematic review of current literature. ( 29954722 )
2018
24
Community-acquired and transfusion-transmitted babesiosis are increasing: why and what to do? ( 29528151 )
2018
25
Babesiosis in Essex, UK: monitoring and learning lessons from a novel disease outbreak. ( 29554939 )
2018
26
A four year epidemiological and chemotherapy survey of babesiosis and theileriosis, and tick vectors in sheep, cattle and goats in Dehgolan, Iran ( 29717573 )
2018
27
The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult. ( 29963524 )
2018
28
A Walk in the Park: A Case of Babesiosis in the South Bronx. ( 29849265 )
2018
29
Babesiosis as a cause of false-positive HIV serology. ( 29884713 )
2018
30
Human Babesiosis Caused by <i>Babesia duncani</i> Has Widespread Distribution across Canada. ( 29772759 )
2018
31
Screening of patient blood samples for babesiosis using enzymatic assays. ( 29150323 )
2018
32
Antiprotozoal treatment of canine babesiosis. ( 29657012 )
2018
33
Development of an Indirect ELISA Based on a Recombinant Chimeric Protein for the Detection of Antibodies against Bovine Babesiosis. ( 29360801 )
2018
34
Babesiosis as a cause of acute respiratory distress syndrome: a series of eight cases. ( 30585748 )
2018
35
Human Babesiosis, Yucatán State, Mexico, 2015. ( 30334701 )
2018
36
Notes from the Field: Reference Laboratory Investigation of Patients with Clinically Diagnosed Lyme Disease and Babesiosis - Indiana, 2016. ( 30335739 )
2018
37
Comparative evaluation of DNA extraction kit, matrix sample and qPCR assays for bovine babesiosis monitoring. ( 30362072 )
2018
38
Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease. ( 30367867 )
2018
39
Transfusion-Transmitted Babesiosis. ( 30376376 )
2018
40
LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study. ( 30485286 )
2018
41
Babesiosis-Associated Splenic Rupture: Case Series from a Hyperendemic Region. ( 30541016 )
2018
42
Babesiosis prevalence in malaria-endemic regions of Colombia. ( 30618449 )
2018
43
Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea. ( 30630283 )
2018
44
Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014. ( 30016247 )
2018
45
Glomerular and tubular kidney damage markers in canine babesiosis caused by Babesia canis. ( 30057291 )
2018
46
Babesiosis and Lyme Disease in a 68-year-old man. ( 30068051 )
2018
47
Fatal human babesiosis caused by Babesia divergens in an asplenic host. ( 30073148 )
2018
48
The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development. ( 30081952 )
2018
49
A review of the history of research and control of Rhipicephalus (Boophilus) microplus, babesiosis and anaplasmosis in Uruguay. ( 30083875 )
2018
50
Response to "Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015: a response to why and what to do". ( 30133825 )
2018

Variations for Babesiosis

Expression for Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for Babesiosis

Pathways related to Babesiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 CD36 THBS1
2 10.42 LRPAP1 RAP1A
3 9.83 RAP1A RAP1B

GO Terms for Babesiosis

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.63 CD36 RAP1A RAP1B
2 response to calcium ion GO:0051592 9.49 MT-CYB THBS1
3 cellular response to cAMP GO:0071320 9.48 RAP1A RAP1B
4 positive regulation of reactive oxygen species metabolic process GO:2000379 9.43 CD36 THBS1
5 microvillus assembly GO:0030033 9.4 RAP1A RAP1B
6 establishment of endothelial barrier GO:0061028 9.37 RAP1A RAP1B
7 positive regulation of blood coagulation GO:0030194 9.32 CD36 THBS1
8 response to carbohydrate GO:0009743 9.26 RAP1A RAP1B
9 Rap protein signal transduction GO:0032486 9.16 RAP1A RAP1B
10 negative regulation of synaptic vesicle exocytosis GO:2000301 8.96 RAP1A RAP1B
11 regulation of cell junction assembly GO:1901888 8.62 RAP1A RAP1B

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.33 MT-CYB RAP1A RAP1B
2 amyloid-beta binding GO:0001540 9.26 CD36 LRPAP1
3 transforming growth factor beta binding GO:0050431 8.96 CD36 THBS1
4 low-density lipoprotein particle binding GO:0030169 8.62 CD36 THBS1

Sources for Babesiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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