MCID: BBS001
MIFTS: 48

Babesiosis

Categories: Blood diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Babesiosis

MalaCards integrated aliases for Babesiosis:

Name: Babesiosis 12 73 20 58 3 3 44 15 17 70 32
Human Babesiosis 20 70
Babesia Parasite Infection 20
Infection by Babesia 12
Piroplasmosis 12
Babesiasis 12

Characteristics:

Orphanet epidemiological data:

58
babesiosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Babesiosis

CDC : 3 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.Although many people who are infected with Babesia do not have symptoms, for those who do effective treatment is available. Babesiosis is preventable, if simple steps are taken to reduce exposure to ticks. Babesia microti is transmitted by the bite of infected Ixodes scapularis ticks-typically, by the nymph stage of the tick, which is about the size of a poppy seed. An Ixodes scapularis nymph is shown on the face of a penny. (Credit: G. Hickling, University of Tennessee)

MalaCards based summary : Babesiosis, also known as human babesiosis, is related to acute kidney failure and trypanosomiasis, and has symptoms including mild fevers and anemia described as malaria-like symptoms. An important gene associated with Babesiosis is HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4), and among its related pathways/superpathways are HIV Life Cycle and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and kidney, and related phenotypes are fever and hemolytic anemia

Disease Ontology : 12 A parasitic protozoa infectious disease that has symptom mild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

GARD : 20 Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells. Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, babesiosis can be associated with hemolytic anemia. Babesia parasites are primarily spread by infected ticks. Treatment is generally only required in people who develop symptoms of the condition. When necessary, affected people are often prescribed a combination of antimicrobial medications along with supportive care to manage symptoms.

Wikipedia : 73 Babesiosis or piroplasmosis is a malaria-like parasitic disease caused by infection with a eukaryotic... more...

Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 acute kidney failure 30.5 HP GPT ALB
2 trypanosomiasis 30.3 HP GPT ALB
3 disease by infectious agent 30.2 HP GPT CD4 ALB
4 bartonellosis 30.1 MT-CYB MT-CO1 CD4
5 sickle cell disease 30.1 THBS1 HP ADAMTSL1
6 fascioliasis 30.0 MT-CO1 GPT ALB
7 thrombotic thrombocytopenic purpura 30.0 THBS1 HP ADAMTSL1
8 plasmodium falciparum malaria 30.0 THBS1 HP CD36
9 bilirubin metabolic disorder 29.8 HP GPT CD4 ALB
10 acute kidney tubular necrosis 29.8 GPT CD4 ALB
11 hemosiderosis 29.8 HP GPT ALB
12 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 29.8 MT-CYB CD4 CCT7
13 deficiency anemia 29.8 MT-CYB HP GPT CD4 ALB
14 coccidiosis 29.8 MT-CYB HSPA4 CD4 ALB
15 pericardial effusion 29.6 GPT CD4 ALB
16 exanthem 29.6 GPT CD4 ALB
17 celiac disease 1 29.4 HP GPT CD4 ALB
18 malaria 29.3 THBS1 MT-CYB HSPA4 HP GPT CD4
19 parasitic protozoa infectious disease 28.9 MT-CYB MT-CO1 HSPA4 HP GPT CD4
20 tick infestation 11.0
21 lyme disease 10.7
22 hemolytic anemia 10.5
23 ehrlichiosis 10.5
24 thrombocytopenia 10.4
25 myiasis 10.4 MT-CYB MT-CO1
26 oesophagostomiasis 10.4 MT-CYB MT-CO1
27 splenomegaly 10.3
28 sparganosis 10.3 MT-CYB MT-CO1
29 dirofilariasis 10.3 MT-CO1 HP
30 acanthocephaliasis 10.3 MT-CO1 ALB
31 pediculus humanus corporis infestation 10.3 MT-CYB MT-CO1
32 human granulocytic anaplasmosis 10.3
33 adult respiratory distress syndrome 10.3
34 pthirus pubis infestation 10.3 MT-CYB MT-CO1 HSPA4
35 heterophyiasis 10.3 GPT ALB
36 afferent loop syndrome 10.3 GPT ALB
37 basidiobolomycosis 10.3 MT-CYB GPT
38 hemoglobinuria 10.3
39 posttransplant acute limbic encephalitis 10.3
40 ankylosing spondylitis 1 10.3 GPT ALB
41 acalculous cholecystitis 10.3 GPT ALB
42 hepatic infarction 10.2 GPT ALB
43 dysferlinopathy 10.2 THBS1 GPT
44 hydrops of gallbladder 10.2 GPT ALB
45 critical illness polyneuropathy 10.2 GPT ALB
46 ascending cholangitis 10.2 GPT ALB
47 disseminated intravascular coagulation 10.2
48 pancytopenia 10.2
49 cyclosporiasis 10.2 MT-CYB CD4
50 myoglobinuria 10.2 MT-CYB MT-CO1 GPT

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to Babesiosis

Symptoms & Phenotypes for Babesiosis

Human phenotypes related to Babesiosis:

58 31 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 hemolytic anemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001878
3 headache 58 31 hallmark (90%) Very frequent (99-80%) HP:0002315
4 hyperhidrosis 58 31 frequent (33%) Frequent (79-30%) HP:0000975
5 splenomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0001744
6 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
7 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
8 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
9 jaundice 58 31 frequent (33%) Frequent (79-30%) HP:0000952
10 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
11 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
12 cough 58 31 frequent (33%) Frequent (79-30%) HP:0012735
13 leukopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001882
14 nausea and vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002017
15 depressivity 58 31 occasional (7.5%) Occasional (29-5%) HP:0000716
16 respiratory insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0002093
17 photophobia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000613
18 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
19 congestive heart failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001635
20 myocardial infarction 58 31 occasional (7.5%) Occasional (29-5%) HP:0001658
21 venous thrombosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004936
22 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
23 recurrent pharyngitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100776
24 hepatic failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001399
25 limitation of joint mobility 58 31 occasional (7.5%) Occasional (29-5%) HP:0001376
26 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
27 confusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0001289
28 clinodactyly of the 5th toe 58 31 occasional (7.5%) Occasional (29-5%) HP:0001864
29 disseminated intravascular coagulation 58 31 occasional (7.5%) Occasional (29-5%) HP:0005521
30 hypercoagulability 58 31 occasional (7.5%) Occasional (29-5%) HP:0100724
31 recurrent infections 58 Frequent (79-30%)

Symptoms:

12
  • mild fevers
  • anemia described as malaria-like symptoms

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Blood Donation Screening for Babesia Microti by Real-time Polymerase Chain Reaction (PCR) and by Indirect Flourescent Antibody (IFA) Assays Completed NCT01528449 Phase 3

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Quinine
QUININE SO4 PWDR
Quinine Sulfate

Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

Anatomical Context for Babesiosis

MalaCards organs/tissues related to Babesiosis:

40
Bone, Heart, Kidney, Spleen, Myeloid, Whole Blood, Salivary Gland

Publications for Babesiosis

Articles related to Babesiosis:

(show top 50) (show all 2573)
# Title Authors PMID Year
1
Control of ixodid ticks and prevention of tick-borne diseases in the United States: The prospect of a new Lyme disease vaccine and the continuing problem with tick exposure on residential properties. 61
33549976 2021
2
A report on tick burden and molecular detection of tick-borne pathogens in cattle blood samples collected from four regions in Saudi Arabia. 61
33465662 2021
3
Three Babesia species in Ixodes ricinus ticks from migratory birds in Sweden. 61
33794970 2021
4
Update on prevalence and distribution pattern of tick-borne diseases among humans in India: a review. 61
33797610 2021
5
Impact of using pyronaridine tetraphosphate- based combination therapy in the treatment of babesiosis caused by Babesia bovis, B. caballi, and B. gibsoni in vitro and B. microti in mice. 61
33264674 2021
6
Survey on tick distribution and tick-borne pathogens in Daejeon and adjacent areas in South Korea. 61
33774480 2021
7
Statewide Passive Surveillance of Ixodes scapularis and Associated Pathogens in Maine. 61
33661033 2021
8
Prevalence of single and coinfections of human pathogens in Ixodes ticks from five geographical regions in the United States, 2013-2019. 61
33360805 2021
9
Cytokine profile and parasite load in lymph nodes of dogs naturally infected with Leishmania infantum from distinct epidemiological scenarios in São Paulo State, Brazil. 61
33548792 2021
10
Performance of a sensitive haemozoin-based malaria diagnostic test validated for vivax malaria diagnosis in Brazilian Amazon. 61
33712019 2021
11
Splenomegaly, Non-Traumatic Splenic Rupture, and Pancytopenia in Patient with Human Granulocytic Anaplasmosis. 61
33648322 2021
12
The Impact of Tick-Borne Diseases on the Bone. 61
33806785 2021
13
End Point Multiplex PCR for Diagnosis of Haemoprotozoan Diseases in Cattle. 61
32757111 2021
14
Prevalence of tick-borne haemoparasites and their perceived co-occurrences with viral outbreaks of FMD and LSD and their associated factors. 61
33768176 2021
15
Systemic inflammatory response syndrome in dogs naturally infected with Babesia canis: Association with the parasite load and host factors. 61
33545559 2021
16
Using Data Surveillance to Understand the Rising Incidence of Babesiosis in the United States, 2011-2018. 61
33739890 2021
17
Evaluation of some acute phase proteins in cattle naturally infected with Babesia bigemina. 61
33735746 2021
18
A Comparative Genomic Study of Attenuated and Virulent Strains of Babesia bigemina. 61
33800466 2021
19
The key to egress? Babesia bovis perforin-like protein 1 (PLP1) with hemolytic capacity is required for blood stage replication and is involved in the exit of the parasite from the host cell. 61
33753093 2021
20
A shared pathogen: Babesia rossi in domestic dogs, black-backed jackals (Canis mesomelas) and African wild dogs (Lycaon pictus) in South Africa. 61
33667987 2021
21
Prognostic markers and their discriminant score in predicting the outcome of Babesia gibsoni infection. 61
33666974 2021
22
Impact of Babesia microti infection on the initiation and course of pregnancy in BALB/c mice. 61
33653384 2021
23
Babesia spp. and Anaplasma phagocytophilum in free-ranging wild ungulates in central Austria. 61
33774481 2021
24
Circulation of Babesia Species and Their Exposure to Humans through Ixodes Ricinus. 61
33804875 2021
25
Babesia bicornis, Theileria bicornis and Theileria equi in metapopulations of two black rhinoceros (Diceros bicornis) subspecies in South Africa and their potential impact on conservation. 61
33373893 2021
26
Babesiosis Occurrence Among United States Medicare Beneficiaries, Ages 65 and Older, During 2006-2017: Overall and by State and County of Residence. 61
33598501 2021
27
Parasite burden and red blood cell exchange transfusion for babesiosis. 61
33179803 2021
28
Analysis of risk factors associated with recurrence of canine babesiosis caused by Babesia gibsoni. 61
33341594 2021
29
Emerging Human Babesiosis with "Ground Zero" in North America. 61
33672522 2021
30
Knowledge, attitude and perception of bovine piroplasmosis by cattle owners in Constantine, North-East of Algeria, using participatory epidemiology. 61
33594496 2021
31
Pathogen Coinfections Harbored by Adult Ixodes scapularis from White-Tailed Deer Compared with Questing Adults Across Sites in Maryland, USA. 61
33316206 2021
32
Babesia microti infection in a patient with multiple sclerosis treated with ocrelizumab. 61
33450528 2021
33
Nosocomial Infections: Do Not Forget the Parasites! 61
33669761 2021
34
Clinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease. 61
33257476 2021
35
Primary Tick-Borne Protozoan and Rickettsial Infections of Animals in Turkey. 61
33669573 2021
36
Activity Comparison of Epigenetic Modulators against the Hemoprotozoan Parasites Babesia divergens and Plasmodium falciparum. 61
33599488 2021
37
Global Distribution of Babesia Species in Questing Ticks: A Systematic Review and Meta-Analysis Based on Published Literature. 61
33669591 2021
38
Exploration of Serum Marker Proteins in Mice Induced by Babesia microti Infection Using a Quantitative Proteomic Approach. 61
33387247 2021
39
Comparative analysis of gene expression between Babesia bovis blood stages and kinetes allowed by improved genome annotation. 61
33069745 2021
40
Effects of white-tailed deer habitat use preferences on southern cattle fever tick eradication: simulating impact on "pasture vacation" strategies. 61
33557915 2021
41
Surveillance of Ticks and Tick-Borne Pathogens in Suburban Natural Habitats of Central Maryland. 61
33511396 2021
42
Association of Presenting Symptoms With Abnormal Laboratory Values for Vector-Borne Illness - Experience in an Urban Gastroenterology Practice. 61
33511252 2021
43
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. 61
33417672 2021
44
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. 61
33483734 2021
45
High Proportion of Unfed Larval Blacklegged Ticks, Ixodes scapularis (Acari: Ixodidae), Collected From Modified Nest Boxes for Mice. 61
33471096 2021
46
Retrotransposon-Based Blood Meal Analysis of Nymphal Deer Ticks Demonstrates Spatiotemporal Diversity of Borrelia burgdorferi and Babesia microti Reservoirs. 61
33158895 2021
47
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. 61
33252652 2021
48
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis. 61
33501959 2021
49
Experimental Infection of Calves with Transfected Attenuated Babesia bovis Expressing the Rhipicephalus microplus Bm86 Antigen and eGFP Marker: Preliminary Studies towards a Dual Anti-Tick/Babesia Vaccine. 61
33572875 2021
50
Ticks and Tick-Borne Diseases of Livestock in the Middle East and North Africa: A Review. 61
33477991 2021

Variations for Babesiosis

Expression for Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for Babesiosis

GO Terms for Babesiosis

Cellular components related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.46 THBS1 CD4 ALB ADAMTSL1
2 extracellular exosome GO:0070062 9.32 THBS1 RPS8 RPL4 RAP1B RAP1A HSPA4
3 mitochondrial respiratory chain complex III GO:0005750 8.96 MT-CYB MT-CO1

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.62 RAP1B RAP1A CD4 CD36
2 response to copper ion GO:0046688 9.48 MT-CYB MT-CO1
3 microvillus assembly GO:0030033 9.46 RAP1B RAP1A
4 positive regulation of blood coagulation GO:0030194 9.43 THBS1 CD36
5 response to carbohydrate GO:0009743 9.4 RAP1B RAP1A
6 Rap protein signal transduction GO:0032486 9.37 RAP1B RAP1A
7 response to calcium ion GO:0051592 9.33 THBS1 MT-CYB HOMER1
8 regulation of cell junction assembly GO:1901888 9.26 RAP1B RAP1A
9 negative regulation of synaptic vesicle exocytosis GO:2000301 8.96 RAP1B RAP1A
10 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-CO1

Sources for Babesiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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