MCID: BBS001
MIFTS: 48

Babesiosis

Categories: Blood diseases, Infectious diseases, Rare diseases
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Aliases & Classifications for Babesiosis

MalaCards integrated aliases for Babesiosis:

Name: Babesiosis 11 19 58 75 2 2 43 14 16 71 31 33
Infection by Babesia 11 33
Human Babesiosis 19 71
Piroplasmosis 11 33
Babesiasis 11 33
Babesia Parasite Infection 19
Piroplasma Infection 33

Characteristics:


Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Babesiosis

CDC: 2 Babesiosis is caused by microscopic parasites that infect red blood cells and are spread by certain ticks. In the United States, tickborne transmission is most common in particular regions and seasons: it mainly occurs in parts of the Northeast and upper Midwest and usually peaks during the warm months.Although many people who are infected with Babesia do not have symptoms, for those who do effective treatment is available. Babesiosis is preventable, if simple steps are taken to reduce exposure to ticks. Babesia microti is transmitted by the bite of infected Ixodes scapularis ticks-typically, by the nymph stage of the tick, which is about the size of a poppy seed. An Ixodes scapularis nymph is shown on the face of a penny. (Credit: G. Hickling, University of Tennessee)

MalaCards based summary: Babesiosis, also known as infection by babesia, is related to tick infestation and ehrlichiosis, and has symptoms including mild fevers and anemia described as malaria-like symptoms. An important gene associated with Babesiosis is HSPA4 (Heat Shock Protein Family A (Hsp70) Member 4), and among its related pathways/superpathways are Metabolism and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include heart, whole blood and salivary gland, and related phenotypes are fever and hemolytic anemia

GARD: 19 Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells. Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, Babesiosis may be associated with hemolytic anemia. Babesia parasites are primarily spread by infected ticks.

Disease Ontology: 11 A parasitic protozoa infectious disease that has symptom mild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

Orphanet: 58 Babesiosis is an infectious disease caused by protozoa of the genus Babesia and characterized by a febrile illness and hemolytic anemia but with manifestations ranging from an asymptomatic infection to a fulminating illness that can result in death.

Wikipedia: 75 Babesiosis or piroplasmosis is a malaria-like parasitic disease caused by infection with a eukaryotic... more...

Related Diseases for Babesiosis

Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 524)
# Related Disease Score Top Affiliating Genes
1 tick infestation 31.5 MT-CYB MT-CO1 HSPD1 CD4 ALB
2 ehrlichiosis 30.8 HSPD1 GPT CD4
3 splenic infarction 30.6 HP GPT ALB
4 acute kidney failure 30.6 HP GPT ALB
5 plasmodium falciparum malaria 30.5 TNF HP CD36
6 deficiency anemia 30.5 TNF HP GPT CD4 ALB
7 theileriasis 30.4 RPS8 MT-CYB MT-CO1 HSPD1
8 pancytopenia 30.3 HP GPT CD4 ALB
9 fascioliasis 30.2 MT-CO1 GPT ALB
10 cystoisosporiasis 30.2 MT-CO1 CD4
11 hemosiderosis 30.1 HP GPT ALB
12 bartonellosis 30.1 MT-CYB MT-CO1 HSPD1 CD4
13 thrombocytopenia 30.1 TNF THBS1 HP GPT CD4 CD36
14 hemophagocytic lymphohistiocytosis 30.0 TNF GPT CD4
15 thrombotic thrombocytopenic purpura 30.0 THBS1 HP CD36 ADAMTSL1
16 rocky mountain spotted fever 30.0 HSPD1 GPT CD4
17 respiratory failure 29.9 TNF GPT CD4 ALB
18 acute kidney tubular necrosis 29.9 TNF GPT ALB
19 cholecystitis 29.9 HP GPT ALB
20 hypersensitivity reaction type iii disease 29.9 TNF CD4 ALB
21 henoch-schoenlein purpura 29.9 TNF CD4 ALB
22 west nile encephalitis 29.9 TNF CD4 ALB
23 leishmaniasis 29.8 TNF HSPA4 GPT ALB
24 spotted fever 29.8 MT-CO1 HSPD1 GPT CD4
25 autoimmune lymphoproliferative syndrome 29.8 TNF MT-CYB MT-CO1 CD4
26 plague 29.8 TNF MT-CYB CD4 ALB
27 acalculous cholecystitis 29.8 GPT CD4 ALB
28 relapsing fever 29.8 TNF MT-CYB HSPD1
29 sickle cell anemia 29.8 TNF HP CD4 CD36 ALB
30 filarial elephantiasis 29.7 TNF MT-CO1 CD4
31 reactive arthritis 29.7 TNF HSPD1 HP
32 hypersensitivity vasculitis 29.7 TNF CD4 ALB
33 peptic ulcer disease 29.7 TNF GPT ALB
34 gilbert syndrome 29.7 HP GPT ALB
35 bilirubin metabolic disorder 29.7 TNF PRODH HP GPT CD4 ALB
36 interstitial nephritis 29.7 TNF CD4 ALB
37 tularemia 29.6 TNF HSPD1 CD4
38 chagas disease 29.6 TNF HSPA4 CD4
39 parkinson disease, late-onset 29.6 PRODH MT-CYB HSPD1 HSPA4 COQ2 ALB
40 trypanosomiasis 29.6 TNF PRODH MT-CYB HP GPT CD4
41 filariasis 29.6 TNF MT-CO1 CD4 ALB
42 crohn's disease 29.5 TNF HP CD4 ALB
43 urethritis 29.5 TNF HSPD1 CD4 ALB
44 pericardial effusion 29.4 TNF GPT CD4 ALB
45 exanthem 29.4 TNF GPT CD4 ALB
46 dengue disease 29.4 TNF GPT CD4 ALB
47 glucosephosphate dehydrogenase deficiency 29.4 TNF PRODH HP GPT ALB
48 coccidiosis 29.4 TNF MT-CYB HSPA4 GPT CD4 ALB
49 arthritis 29.4 TNF HSPD1 HSPA4 GPT ALB
50 celiac disease 1 29.3 TNF HP GPT CD4 ALB

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to Babesiosis

Symptoms & Phenotypes for Babesiosis

Human phenotypes related to Babesiosis:

58 30 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001945
2 hemolytic anemia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001878
3 headache 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0002315
4 hyperhidrosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0000975
5 splenomegaly 58 30 Frequent (33%) Frequent (79-30%)
HP:0001744
6 hepatomegaly 58 30 Frequent (33%) Frequent (79-30%)
HP:0002240
7 fatigue 58 30 Frequent (33%) Frequent (79-30%)
HP:0012378
8 thrombocytopenia 58 30 Frequent (33%) Frequent (79-30%)
HP:0001873
9 jaundice 58 30 Frequent (33%) Frequent (79-30%)
HP:0000952
10 arthralgia 58 30 Frequent (33%) Frequent (79-30%)
HP:0002829
11 myalgia 58 30 Frequent (33%) Frequent (79-30%)
HP:0003326
12 cough 58 30 Frequent (33%) Frequent (79-30%)
HP:0012735
13 leukopenia 58 30 Frequent (33%) Frequent (79-30%)
HP:0001882
14 nausea and vomiting 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002017
15 depression 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000716
16 respiratory insufficiency 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002093
17 photophobia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000613
18 renal insufficiency 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0000083
19 congestive heart failure 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001635
20 myocardial infarction 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001658
21 venous thrombosis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0004936
22 anorexia 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002039
23 recurrent pharyngitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100776
24 hepatic failure 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001399
25 limitation of joint mobility 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001376
26 coma 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001259
27 confusion 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001289
28 clinodactyly of the 5th toe 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001864
29 disseminated intravascular coagulation 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0005521
30 hypercoagulability 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100724
31 recurrent infections 58 Frequent (79-30%)

Symptoms:

11
  • mild fevers
  • anemia described as malaria-like symptoms

Drugs & Therapeutics for Babesiosis

Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Blood Donation Screening for Babesia Microti by Real-time Polymerase Chain Reaction (PCR) and by Indirect Flourescent Antibody (IFA) Assays Completed NCT01528449 Phase 3
2 Description of Case of Infection With a New Species of Babesia and Its Molecular Diagnosis Recruiting NCT04960995

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Quinine
QUININE SO4 PWDR
Quinine Sulfate

Cochrane evidence based reviews: babesiosis

Genetic Tests for Babesiosis

Anatomical Context for Babesiosis

Organs/tissues related to Babesiosis:

MalaCards : Heart, Whole Blood, Salivary Gland, Spleen, Bone Marrow, Kidney, T Cells

Publications for Babesiosis

Articles related to Babesiosis:

(show top 50) (show all 3403)
# Title Authors PMID Year
1
Serum and urine profiling by high-throughput TMT-based proteomics for the investigation of renal dysfunction in canine babesiosis. 62
36174949 2023
2
Animal models of the immunology and pathogenesis of human babesiosis. 62
36470781 2022
3
Economic impact of predominant ticks and tick-borne diseases on Indian dairy production systems. 62
36336025 2022
4
Nested qPCR assay to detect Babesia duncani infection in hamsters and humans. 62
36192649 2022
5
Predicting the potential distribution of the cattle fever tick Rhipicephalus annulatus (Acari: Ixodidae) using ecological niche modeling. 62
36136139 2022
6
Prevalence and phylogenetic analysis of Babesia parasites in reservoir host species in Fujian province, Southeast China. 62
35819239 2022
7
Prevalence of Babesia spp. pathogens in the ticks Dermacentor reticulatus and Ixodes ricinus in the UK. 62
36115381 2022
8
Splenic diffuse heterogeneous hypoechogenicity pattern of dogs and cats: A systematic review. 62
35933802 2022
9
First Report of Babesia gibsoni in Cats in China. 62
36428294 2022
10
Babesia in North America: An Update. 62
36336417 2022
11
Deployment of a reservoir-targeted vaccine against Borreliella burgdorferi reduces the prevalence of Babesia microti coinfection in Ixodes scapularis ticks. 62
36416014 2022
12
First report of canine rangeliosis in domestic dogs from different regions of Santa Catarina State, Brazil. 62
36436892 2022
13
Comparing the Epidemiology and Health Burden of Lyme Disease and Babesiosis Hospitalizations in the United States. 62
36467296 2022
14
Theileria equi in the horses of Iran: Molecular detection, genetic diversity, and hematological findings. 62
36436901 2022
15
Thrombospondin-Related Anonymous Protein (TRAP) Family Expression by Babesia bovis Life Stages within the Mammalian Host and Tick Vector. 62
36363765 2022
16
The First Records of Canine Babesiosis in Dogs from Dermacentor reticulatus-Free Zone in Poland. 62
36422581 2022
17
Successful treatment of babesiosis in a south-western black rhinoceros(Diceros bicornis bicornis). 62
35934911 2022
18
The presence of malignant ovine babesiosis in Bosnia and Herzegovina indicates a possible emerging risk for Balkan region. 62
36240662 2022
19
Sensitive and rapid detection of Babesia species in dogs by recombinase polymerase amplification with lateral flow dipstick (RPA-LFD). 62
36446883 2022
20
Genetic diversity in Babesia bovis from southern Africa and estimation of B. bovis infection levels in cattle using an optimised quantitative PCR assay. 62
36427476 2022
21
A vaccine for human babesiosis: prospects and feasibility. 62
35933301 2022
22
Procalcitonin as a Potential Biomarker in the Study of Babesiosis Caused by B. microti. 62
36364974 2022
23
Periviscerokinin (Cap2b; CAPA) receptor silencing in females of Rhipicephalus microplus reduces survival, weight and reproductive output. 62
36203198 2022
24
Novel equi merozoite antigen (ema-1) gene heterogeneity in a geographically isolated Theileria equi population in Croatia. 62
36316753 2022
25
Delivery and effectiveness of entomopathogenic fungi for mosquito and tick control: Current knowledge and research challenges. 62
35914564 2022
26
Molecular Epidemiological Investigation of Piroplasms and Anaplasmataceae Bacteria in Egyptian Domestic Animals and Associated Ticks. 62
36297251 2022
27
A novel promising diagnostic candidate selected by screening the transcriptome of Babesia gibsoni (Wuhan isolate) asexual stages in infected beagles. 62
36217160 2022
28
Seasonal fluctuations of Babesia bigemina and Rhipicephalus microplus in Brangus and Nellore cattle reared in the Cerrado biome, Brazil. 62
36307861 2022
29
Molecular epidemiology and characterization of Babesia bovis in cattle of Khyber Pakhtunkhwa province, Pakistan. 62
36208348 2022
30
Failure of an Approximately Six Week Course of Tafenoquine to Completely Eradicate Babesia microti Infection in an Immunocompromised Patient. 62
36145484 2022
31
Repurposing of the Malaria Box for Babesia microti in mice identifies novel active scaffolds against piroplasmosis. 62
36123705 2022
32
Incidences of Rhipicephalus (Boophilus) microplus (Canestrini, 1888) Transmitted Pathogens in Cattle in West Africa. 62
35713759 2022
33
Eco-epidemiology of equine piroplasmosis and its associated tick vectors in Europe: A systematic literature review and a meta-analysis of prevalence. 62
34333863 2022
34
High genetic diversity of Babesia canis (Piana & Galli-Valerio, 1895) in a recent local outbreak in Berlin/ Brandenburg, Germany. 62
35689449 2022
35
Babesia duncani as a Model Organism to Study the Development, Virulence, and Drug Susceptibility of Intraerythrocytic Parasites In Vitro and In Vivo. 62
35512141 2022
36
First Molecular Identification of Babesia, Theileria, and Anaplasma in Goats from the Philippines. 62
36297166 2022
37
Development of a duplex real-time PCR assay for simultaneous detection and differentiation of Theileria equi and Babesia caballi. 62
35089645 2022
38
In vivo activity and atom pair fingerprint analysis of MMV665941 against the apicomplexan parasite Babesia microti, the causative agent of babesiosis in humans and rodents. 62
36172647 2022
39
A prime-boost combination of a three-protein cocktail and multiepitopic MVA as a vaccine against Babesia bigemina elicits neutralizing antibodies and a Th1 cellular immune response in mice. 62
35792436 2022
40
Clinical and Hematologic Findings in Babesia canis Infection in Eastern Slovakia. 62
35831668 2022
41
Efficacy of the Antimalarial MMV390048 against Babesia Infection Reveals Phosphatidylinositol 4-Kinase as a Druggable Target for Babesiosis. 62
35924942 2022
42
High Asymptomatic Cases of Babesiosis in Dogs and Comparison of Diagnostic Performance of Conventional PCR vs Blood Smears. 62
35612719 2022
43
Human Babesiosis. 62
36116841 2022
44
Propagation of Babesia bigemina in Rabbit Model and Evaluation of Its Attenuation in Cross-Bred Calves. 62
36078007 2022
45
Specific and Sensitive Diagnosis of Babesia microti Active Infection Using Monoclonal Antibodies to the Immunodominant Antigen BmGPI12. 62
36040206 2022
46
Elucidating Parasite and Host Cell Factors Enabling Babesia Infection in Sickle Red Cells under Hypoxic/Hyperoxic Conditions. 62
35977077 2022
47
Molecular Reports of Ruminant Babesia in Southeast Asia. 62
36015035 2022
48
Bovine babesiosis in India: Estimation of prevalence by systematic review and meta analysis. 62
35779644 2022
49
Correction: Kumar et al. The Global Emergence of Human Babesiosis. Pathogens 2021, 10, 1447. 62
36015072 2022
50
Extraordinary high level of propagation of Babesia divergens in severe human babesiosis. 62
35591780 2022

Variations for Babesiosis

Expression for Babesiosis

Search GEO for disease gene expression data for Babesiosis.

Pathways for Babesiosis

GO Terms for Babesiosis

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell death GO:0010942 9.43 PRODH HP CD36
2 positive regulation of blood microparticle formation GO:2000334 8.92 TNF CD36

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent protein folding chaperone GO:0140662 9.1 HSPD1 HSPA4 CCT7

Sources for Babesiosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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