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MCID: BBS001
MIFTS: 51

Babesiosis

Categories: Blood diseases, Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Babesiosis

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MalaCards integrated aliases for Babesiosis:

Name: Babesiosis 12 77 54 60 3 45 15 17 74
Human Babesiosis 54 74
Babesia Parasite Infection 54
Infection by Babesia 12
Piroplasmosis 12
Babesiasis 12

Characteristics:

Orphanet epidemiological data:

60
babesiosis
Inheritance: Not applicable; Age of onset: All ages; Age of death: adult;

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34 35
Orphanet: 60  
Rare infectious diseases


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Summaries for Babesiosis

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NIH Rare Diseases : 54 Babesiosis refers to a condition caused by microscopic parasites that infect the red blood cells. Many people who are infected with Babesia parasites do not experience any symptoms of the condition. When present, signs and symptoms may include flu-like symptoms such as fever, chills, headache, body aches, nausea and fatigue. In severe cases, babesiosis can be associated with hemolytic anemia. Babesia parasites are primarily spread by infected ticks. Treatment is generally only required in people who develop symptoms of the condition. When necessary, affected people are often prescribed a combination of antimicrobial medications along with supportive care to manage symptoms.

MalaCards based summary : Babesiosis, also known as human babesiosis, is related to malaria and tick infestation, and has symptoms including mild fevers and anemia described as malaria-like symptoms. An important gene associated with Babesiosis is CCT7 (Chaperonin Containing TCP1 Subunit 7), and among its related pathways/superpathways are Malaria and Reelin signaling pathway. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and heart, and related phenotypes are fever and hemolytic anemia

Disease Ontology : 12 A parasitic protozoa infectious disease that has symptom mild fevers and has symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

CDC : 3  

Wikipedia : 77 Babesiosis is a malaria-like parasitic disease caused by infection with Babesia, a type of Apicomplexa.... more...

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Related Diseases for Babesiosis

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Diseases related to Babesiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 malaria 29.9 ADAMTSL1 CD36 MT-CO1 MT-CYB THBS1
2 tick infestation 11.5
3 lyme disease 10.6
4 ehrlichiosis 10.5
5 human granulocytic anaplasmosis 10.2
6 platelet glycoprotein iv deficiency 10.2 CD36 THBS1
7 trypanosomiasis 10.2
8 thrombotic thrombocytopenic purpura 10.2 ADAMTSL1 THBS1
9 deficiency anemia 10.1
10 thrombocytopenia 10.1
11 theileriasis 10.1
12 acute respiratory distress syndrome 10.1
13 corneal neovascularization 10.1 CD36 THBS1
14 influenza 10.1
15 hemolytic anemia 10.1
16 bartonellosis 10.1
17 muscle disorders 10.0
18 brucellosis 10.0
19 q fever 10.0
20 glanders 10.0
21 myopathy 10.0
22 pfeiffer syndrome 10.0
23 buschke-ollendorff syndrome 10.0
24 anemia, autoimmune hemolytic 10.0
25 sickle cell anemia 10.0
26 adult respiratory distress syndrome 10.0
27 spotted fever 10.0
28 splenic infarction 10.0
29 evans' syndrome 10.0
30 sparganosis 9.9 MT-CO1 MT-CYB
31 pediculus humanus capitis infestation 9.9 MT-CO1 MT-CYB
32 amelogenesis imperfecta, type iv 9.9 MT-CO1 MT-CYB
33 alveolar echinococcosis 9.9 CD36 MT-CO1
34 myasthenic syndrome, congenital, 10 9.9 MT-CO1 MT-CYB
35 leber optic atrophy 9.8 MT-CO1 MT-CYB
36 blood group, colton system 9.8
37 multiple sclerosis 9.8
38 systemic lupus erythematosus 9.8
39 rheumatoid arthritis 9.8
40 celiac disease 1 9.8
41 aceruloplasminemia 9.8
42 infantile liver failure syndrome 1 9.8
43 acute liver failure 9.8
44 alopecia 9.8
45 arthritis 9.8
46 crohn's disease 9.8
47 hematopoietic stem cell transplantation 9.8
48 leukemia 9.8
49 neutropenia 9.8
50 rocky mountain spotted fever 9.8

Graphical network of the top 20 diseases related to Babesiosis:



Diseases related to Babesiosis
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Symptoms & Phenotypes for Babesiosis

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Human phenotypes related to Babesiosis:

60 33 (show all 31)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
2 hemolytic anemia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001878
3 headache 60 33 hallmark (90%) Very frequent (99-80%) HP:0002315
4 hyperhidrosis 60 33 frequent (33%) Frequent (79-30%) HP:0000975
5 splenomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0001744
6 hepatomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0002240
7 fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012378
8 arthralgia 60 33 frequent (33%) Frequent (79-30%) HP:0002829
9 thrombocytopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001873
10 jaundice 60 33 frequent (33%) Frequent (79-30%) HP:0000952
11 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
12 cough 60 33 frequent (33%) Frequent (79-30%) HP:0012735
13 leukopenia 60 33 frequent (33%) Frequent (79-30%) HP:0001882
14 depressivity 60 33 occasional (7.5%) Occasional (29-5%) HP:0000716
15 nausea and vomiting 60 33 occasional (7.5%) Occasional (29-5%) HP:0002017
16 respiratory insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0002093
17 renal insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0000083
18 photophobia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000613
19 hypercoagulability 60 33 occasional (7.5%) Occasional (29-5%) HP:0100724
20 myocardial infarction 60 33 occasional (7.5%) Occasional (29-5%) HP:0001658
21 congestive heart failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0001635
22 limitation of joint mobility 60 33 occasional (7.5%) Occasional (29-5%) HP:0001376
23 venous thrombosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004936
24 anorexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002039
25 confusion 60 33 occasional (7.5%) Occasional (29-5%) HP:0001289
26 hepatic failure 60 33 occasional (7.5%) Occasional (29-5%) HP:0001399
27 coma 60 33 occasional (7.5%) Occasional (29-5%) HP:0001259
28 recurrent pharyngitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100776
29 disseminated intravascular coagulation 60 33 occasional (7.5%) Occasional (29-5%) HP:0005521
30 clinodactyly of the 5th toe 60 33 occasional (7.5%) Occasional (29-5%) HP:0001864
31 recurrent infections 60 Frequent (79-30%)

Symptoms:

12
  • • mild fevers
  • • anemia described as malaria-like symptoms
Sources

Drugs & Therapeutics for Babesiosis

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Drugs for Babesiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antibodies Phase 3
3
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Babesia Testing in Blood Donors Completed NCT01528449 Phase 3
2 Fever After Tick Bite Study Recruiting NCT03932448

Search NIH Clinical Center for Babesiosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: babesiosis

Sources

Genetic Tests for Babesiosis

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Anatomical Context for Babesiosis

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MalaCards organs/tissues related to Babesiosis:

42
Testes, Liver, Heart, Kidney, Endothelial, Pituitary, Whole Blood
Sources

Publications for Babesiosis

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Articles related to Babesiosis:

(show top 50) (show all 915)
# Title Authors Year
1
Retrospective study of epidemiological, clinical and pathological findings of bovine babesiosis in Mato Grosso do Sul, Brazil (1995 -2017). ( 30196016 )
2019
2
Vectors of Babesiosis. ( 30272993 )
2019
3
Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease. ( 30367867 )
2019
4
Transfusion-Transmitted Babesiosis. ( 30376376 )
2019
5
Optimizing exchange transfusion for patients with severe Babesia divergens babesiosis: Therapeutically-Rational Exchange (T-REX) of M antigen-negative and/or S antigen-negative red blood cells should be evaluated now. ( 30447802 )
2019
6
Vaccination against babesiosis using recombinant GPI-anchored proteins. ( 30684517 )
2019
7
Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit? ( 30690089 )
2019
8
Human babesiosis. ( 30690090 )
2019
9
Congenital Babesiosis From Maternal Exposure: A Case Report. ( 30709608 )
2019
10
Transgenic Babesia bovis lacking 6-Cys sexual-stage genes as the foundation for non-transmissible live vaccines against bovine babesiosis. ( 30711475 )
2019
11
Splenic infarction as a rare presentation of severe babesiosis. ( 30740305 )
2019
12
Human Babesiosis in China: a systematic review. ( 30770979 )
2019
13
Inaugural meeting of the international babesiosis research community, 2018: A glimpse into the future of an emerging research field. ( 30827459 )
2019
14
Increasing Babesiosis in Southeastern Pennsylvania, 2008-2017. ( 30895205 )
2019
15
A novel Babesia sp. associated with clinical signs of babesiosis in domestic cats in South Africa. ( 30909950 )
2019
16
Vitamin D status in dogs with babesiosis. ( 31038320 )
2019
17
Babesiosis in Pregnancy: An Imitator of HELLP Syndrome. ( 31041119 )
2019
18
Babesiosis Masquerading as Evans Syndrome. ( 30904506 )
2019
19
Antiprotozoal treatment of canine babesiosis. ( 29657012 )
2018
20
Human babesiosis, renal failure, and dialysis: A summary and comment on forgotten disease. ( 29657228 )
2018
21
A four year epidemiological and chemotherapy survey of babesiosis and theileriosis, and tick vectors in sheep, cattle and goats in Dehgolan, Iran ( 29717573 )
2018
22
Human Babesiosis Caused by Babesia duncani Has Widespread Distribution across Canada. ( 29772759 )
2018
23
A Walk in the Park: A Case of Babesiosis in the South Bronx. ( 29849265 )
2018
24
Babesiosis as a cause of false-positive HIV serology. ( 29884713 )
2018
25
Splenic rupture from babesiosis, an emerging concern? A systematic review of current literature. ( 29954722 )
2018
26
The first concurrent diagnosis of acute symptomatic Babesiosis and chronic myeloid leukemia in a healthy young adult. ( 29963524 )
2018
27
Canine babesiosis treatment rates in South African veterinary clinics between 2011 and 2016. ( 29970141 )
2018
28
Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014. ( 30016247 )
2018
29
Glomerular and tubular kidney damage markers in canine babesiosis caused by Babesia canis. ( 30057291 )
2018
30
Babesiosis and Lyme Disease in a 68-year-old man. ( 30068051 )
2018
31
Fatal human babesiosis caused by Babesia divergens in an asplenic host. ( 30073148 )
2018
32
The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development. ( 30081952 )
2018
33
A review of the history of research and control of Rhipicephalus (Boophilus) microplus, babesiosis and anaplasmosis in Uruguay. ( 30083875 )
2018
34
Response to "Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015: a response to why and what to do". ( 30133825 )
2018
35
Transfusion-transmitted and community-acquired babesiosis in New York, 2004 to 2015: a response to why and what to do. ( 30133827 )
2018
36
Genetic Analysis of Babesia Isolates from Cattle with Clinical Babesiosis in Sri Lanka. ( 30158190 )
2018
37
Beware of babesiosis: A rare and severe case causing death. ( 30177264 )
2018
38
Variable clinical presentations of babesiosis. ( 30234826 )
2018
39
Transfusion-transmitted babesiosis: one state's experience. ( 30260481 )
2018
40
Human Babesiosis, Yucatán State, Mexico, 2015. ( 30334701 )
2018
41
Notes from the Field: Reference Laboratory Investigation of Patients with Clinically Diagnosed Lyme Disease and Babesiosis - Indiana, 2016. ( 30335739 )
2018
42
Comparative evaluation of DNA extraction kit, matrix sample and qPCR assays for bovine babesiosis monitoring. ( 30362072 )
2018
43
Babesiosis as a cause of acute respiratory distress syndrome: a series of eight cases. ( 30585748 )
2018
44
LC-MS/MS analysis of the dog serum phosphoproteome reveals novel and conserved phosphorylation sites: Phosphoprotein patterns in babesiosis caused by Babesia canis, a case study. ( 30485286 )
2018
45
Babesiosis-Associated Splenic Rupture: Case Series from a Hyperendemic Region. ( 30541016 )
2018
46
Babesiosis prevalence in malaria-endemic regions of Colombia. ( 30618449 )
2018
47
Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea. ( 30630283 )
2018
48
Pathological and molecular diagnosis of canine babesiosis in Nigeria: A case report. ( 31014721 )
2018
49
Transfusion-transmitted babesiosis leading to severe hemolysis in two patients with sickle cell anemia. ( 28766838 )
2018
50
Prevalence, risk factors and vectors identification of bovine anaplasmosis and babesiosis in and around Jimma town, Southwestern Ethiopia. ( 28939494 )
2018
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Variations for Babesiosis

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Expression for Babesiosis

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Search GEO for disease gene expression data for Babesiosis.
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Pathways for Babesiosis

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Pathways related to Babesiosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Malaria 38
10.85 CD36 THBS1
2
Reelin signaling pathway 1
10.42 LRPAP1 RAP1A
3
Rap1 signalling 67
9.83 RAP1A RAP1B
Sources

GO Terms for Babesiosis

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Cellular components related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial respiratory chain complex III GO:0005750 8.62 MT-CO1 MT-CYB

Biological processes related to Babesiosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.67 CD36 RAP1A RAP1B
2 cellular response to cAMP GO:0071320 9.51 RAP1A RAP1B
3 positive regulation of reactive oxygen species metabolic process GO:2000379 9.48 CD36 THBS1
4 microvillus assembly GO:0030033 9.46 RAP1A RAP1B
5 response to copper ion GO:0046688 9.43 MT-CO1 MT-CYB
6 establishment of endothelial barrier GO:0061028 9.4 RAP1A RAP1B
7 positive regulation of blood coagulation GO:0030194 9.37 CD36 THBS1
8 response to carbohydrate GO:0009743 9.32 RAP1A RAP1B
9 Rap protein signal transduction GO:0032486 9.26 RAP1A RAP1B
10 negative regulation of synaptic vesicle exocytosis GO:2000301 9.16 RAP1A RAP1B
11 electron transport coupled proton transport GO:0015990 8.96 MT-CO1 MT-CYB
12 regulation of cell junction assembly GO:1901888 8.62 RAP1A RAP1B

Molecular functions related to Babesiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.33 MT-CYB RAP1A RAP1B
2 transforming growth factor beta binding GO:0050431 8.96 CD36 THBS1
3 low-density lipoprotein particle binding GO:0030169 8.62 CD36 THBS1
Sources

Sources for Babesiosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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