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MIFTS: 47

Back Pain

Categories: Muscle diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Back Pain

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MalaCards integrated aliases for Back Pain:

Name: Back Pain 53 42

Classifications:

MalaCards categories:
Anatomical: Muscle diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Back Pain

About this section
MedlinePlus : 42 If you've ever groaned, "Oh, my aching back!", you are not alone. Back pain is one of the most common medical problems, affecting 8 out of 10 people at some point during their lives. Back pain can range from a dull, constant ache to a sudden, sharp pain. Acute back pain comes on suddenly and usually lasts from a few days to a few weeks. Back pain is called chronic if it lasts for more than three months. Most back pain goes away on its own, though it may take awhile. Taking over-the-counter pain relievers and resting can help. However, staying in bed for more than 1 or 2 days can make it worse. If your back pain is severe or doesn't improve after three days, you should call your health care provider. You should also get medical attention if you have back pain following an injury. Treatment for back pain depends on what kind of pain you have, and what is causing it. It may include hot or cold packs, exercise, medicines, injections, complementary treatments, and sometimes surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Back Pain is related to spinal stenosis and radiculopathy. An important gene associated with Back Pain is COL9A3 (Collagen Type IX Alpha 3 Chain), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Toll Comparative Pathway. The drugs Oxymetazoline and Levobupivacaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone and bone marrow, and related phenotypes are cardiovascular system and hematopoietic system

NINDS : 53 Acute or short-term low back pain generally lasts from a few days to a few weeks. Most acute back pain is the result of trauma to the lower back or a disorder such as arthritis. Pain from trauma may be caused by a sports injury, work around the house or in the garden, or a sudden jolt such as a car accident or other stress on spinal bones and tissues. Symptoms may range from muscle ache to shooting or stabbing pain, limited flexibility and range of motion, or an inability to stand straight. Chronic back pain is pain that persists for more than 3 months. It is often progressive and the cause can be difficult to determine.

Wikipedia : 74 Back pain, also known as backache, is pain felt in the back. Back pain is divided into neck pain... more...

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Related Diseases for Back Pain

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Diseases related to Back Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 967)
# Related Disease Score Top Affiliating Genes
1 spinal stenosis 31.5 THBS2 COL9A3 CALCA
2 radiculopathy 31.3 IL6 IL1A
3 listeriosis 31.3 IL6 IL1B
4 degenerative disc disease 31.2 COMT COL9A3 CALCA
5 somatization disorder 30.6 IL6 COMT
6 spondyloarthropathy 30.6 IL6 IL1B CALCA
7 anxiety 30.5 IL6 IL1B COMT
8 fibromyalgia 30.5 IL6 IL1B COMT CALCA
9 pain agnosia 30.5 IL6 IL1B COMT CALCA
10 psoriatic arthritis 30.5 IL6 IL1RN IL1B IL1A
11 alexithymia 30.4 IL6 COMT
12 mental depression 30.4 IL6 IL1B COMT
13 arachnoiditis 30.4 IL1B IL1A
14 bursitis 30.4 IL6 IL1B CALCA
15 iridocyclitis 30.4 IL6 IL1B
16 sleep disorder 30.4 IL6 IL1B COMT
17 osteoarthritis 30.3 IL6 IL1RN IL1B IL1A
18 bone resorption disease 30.3 IL6 IL1B CALCA
19 uveitis 30.2 IL6 IL1B IL1A
20 intervertebral disc disease 30.2 THBS2 IL6 IL1RN IL1B IL1A COL9A3
21 migraine with or without aura 1 30.1 IL6 IL1B COMT CALCA
22 paine syndrome 30.1 IL6 IL1B COMT CALCA
23 post-traumatic stress disorder 30.1 IL1RN IL1B COMT
24 dysthymic disorder 30.1 IL6 COMT
25 tendinitis 30.1 IL6 IL1B
26 irritable bowel syndrome 30.0 IL6 IL1B COMT
27 osteitis fibrosa 30.0 IL6 CALCA
28 neurotic disorder 30.0 IL6 COMT
29 myositis 30.0 IL6 IL1B IL1A
30 complex regional pain syndrome 30.0 IL6 IL1B CALCA
31 traumatic brain injury 29.9 IL6 IL1B COMT
32 carpal tunnel syndrome 29.9 IL6 IL1B COMT
33 lung abscess 29.9 IL6 IL1B
34 brain injury 29.8 IL6 IL1B COMT
35 arthritis 29.8 IL6 IL1RN IL1B IL1A
36 bone disease 29.8 IL6 IL1B IL1A CALCA
37 cysticercosis 29.8 IL6 IL1B
38 endophthalmitis 29.8 IL6 IL1B
39 meningitis 29.8 IL6 IL1B IL1A
40 aortitis 29.8 IL6 IL1RN IL1B
41 temporal arteritis 29.7 IL6 IL1RN IL1B
42 prostatitis 29.7 IL6 IL1B IL1A
43 rheumatoid arthritis 29.7 IL6 IL1RN IL1B IL1A
44 sarcoidosis 1 29.7 IL1RN IL1B IL1A
45 crohn's disease 29.7 IL6 IL1B IL1A
46 bone inflammation disease 29.7 IL6 IL1RN IL1B IL1A
47 obsessive-compulsive disorder 29.6 IL6 IL1B COMT
48 disease by infectious agent 29.6 IL6 IL1RN IL1B
49 osteomyelitis 29.6 IL6 IL1RN IL1B IL1A CALCA
50 gastritis 29.6 IL6 IL1RN IL1B

Graphical network of the top 20 diseases related to Back Pain:



Diseases related to Back Pain
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Symptoms & Phenotypes for Back Pain

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MGI Mouse Phenotypes related to Back Pain:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 COL9A3 COMT IL1A IL1B IL1RN IL6
2 hematopoietic system MP:0005397 9.5 COL9A3 COMT IL1A IL1B IL1RN IL6
3 immune system MP:0005387 9.17 COL9A3 COMT IL1A IL1B IL1RN IL6
Sources

Drugs & Therapeutics for Back Pain

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Drugs for Back Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 344)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
2
Levobupivacaine Approved, Investigational Phase 4 27262-47-1 92253
3
Coal tar Approved Phase 4 8007-45-2
4
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
5
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
6 Ginger Approved Phase 4
7
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
8
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
9
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
10
Methocarbamol Approved, Vet_approved Phase 4 532-03-6 4107
11
Tizanidine Approved, Investigational Phase 4 51322-75-9 5487
12
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
13
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
14
Promethazine Approved, Investigational Phase 4 60-87-7 4927
15
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
16
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
17
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
18
Codeine Approved, Illicit Phase 4 76-57-3 5284371
19
Methadone Approved Phase 4 76-99-3 4095
20
Metaxalone Approved Phase 4 1665-48-1 15459
21
Baclofen Approved Phase 4 1134-47-0 2284
22
Apomorphine Approved, Investigational Phase 4 58-00-4, 41372-20-7 6005
23
Ibuprofen Approved Phase 4 15687-27-1 3672
24
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
25
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
26
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
27
Norepinephrine Approved Phase 4 51-41-2 439260
28
Methylcobalamin Approved, Investigational Phase 4 13422-55-4
29
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 15589840
30
Sodium citrate Approved, Investigational Phase 4 68-04-2
31
Menthol Approved Phase 4 2216-51-5 16666
32
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
33
Eplerenone Approved Phase 4 107724-20-9 150310 443872
34
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
35
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
36
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
37
tannic acid Approved Phase 4 1401-55-4
38
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
39
Acetaminophen Approved Phase 4 103-90-2 1983
40
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
41
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
42
Donepezil Approved Phase 4 120014-06-4 3152
43
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
44
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
45
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
46
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
47
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6, 59-43-8 1130
48
Cyanocobalamin Approved, Nutraceutical Phase 4 68-19-9 44176380
49
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
50
Cobalamin Experimental Phase 4 13408-78-1 6857388

Interventional clinical trials:

(show top 50) (show all 1907)
# Name Status NCT ID Phase Drugs
1 Botulinum Toxin A for the Treatment of Chronic Lumbar Back Pain: A Prospective Randomized Double-blind Placebo-controlled Crossover Study Unknown status NCT00404417 Phase 4 Botulinum Toxin A / Placebo;Botulinum Toxin A / Botulinum Toxin A;Placebo / Botulinum Toxin A;Placebo / Placebo
2 Therapeutic Effects of Video Game Play Therapy on Patients With Chronic Low Back Pain:Randomized-Controlled Clinical Trail Unknown status NCT02125968 Phase 4
3 Therapeutic Effects of Monochromatic Infrared Energy Therapy on Patients With Chronic Low Back Pain: A Double-Blind, Randomized, Placebo-Controlled Study Unknown status NCT01920971 Phase 4
4 Pharmacological Anxiolysis With Promethazine as an Adjunctive Therapy for Acute Low Back Pain in the Adult Emergency Department Unknown status NCT01129934 Phase 4 Morphine-Promethazine;morphine
5 Adjunctive 5% Lidocaine Patches in the Treatment of Acute Non-radicular Low Back Pain in Patients Discharged From the Emergency Department Unknown status NCT03301766 Phase 4 lidocaine 5% patch;standard therapy;Non-medicated patch
6 Evaluation of the Efficacy and Tolerability of Etoricoxib Monotherapy Versus Combination Oxycodone-etoricoxib in Moderate to Severe Pain From Chronic Low Back Pain Unknown status NCT01344720 Phase 4 etoricoxib;oxycodone
7 The Analgesic Effects of Morphine Versus Ketorolac in Low Back Pain Unknown status NCT02782286 Phase 4 Ketorolac;Morphine
8 A Double-Blind, Randomized, Placebo-Controlled Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain (Lbp) Unknown status NCT00444990 Phase 4
9 Comparison of Ketoprofen Gel to Placebo in Patients Presented With Mechanical Low Back Pain to the Emergency Department: A Randomized Placebo Controlled Trial Unknown status NCT02619695 Phase 4 Fastjel
10 Effect of Three Therapeutic Strategies on the Restriction of the Participation of Patients With a Chronic Back Pain : Multidisciplinary is it the Key Component ? Unknown status NCT02030171 Phase 4
11 Ketoprofen Gel vs Placebo in Patients Presented With Low-back Pain to Emergency Department: A Ranodmized Controlled Trial Unknown status NCT02491879 Phase 4 Ketoprofen
12 Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Low Back Pain Presented to the Emergency Department: A Randomized, Double-Blind, Controlled Trial Unknown status NCT02836509 Phase 4 Paracetamol;Ibuprofen
13 Brain Mechanisms For Clinical Placebo in Chronic Pain: A Randomized Clinical Trial of Placebo, Active Treatment, and No Treatment in Chronic Back Pain Unknown status NCT02986334 Phase 4 Naproxen;Omeprazole;Placebo
14 Transforaminal Epidural Steroid Injection in Conjunction With Pulsed Radiofrequency Treatment of the Lumbar Dorsal Root Ganglion for the Management of Chronic Lumbosacral Radicular Pain: a Randomized, Double-blind Trial Unknown status NCT02930057 Phase 4 Celestone;Control
15 A Prospective Study of the InterFuse T(tm) Unknown status NCT02678130 Phase 4
16 The Effect of Ketamine Infusion for Reduction of Neuropathic Pain and Improvement of Quality of Life After Lumbar Surgery Unknown status NCT02154438 Phase 4 Ketamine
17 A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY ON MAGNETIC FIELD THERAPY TO IMPROVE CHRONIC LUMBAR PAIN Unknown status NCT00407615 Phase 4
18 A Double-Blind, Randomized, Placebo-Controlled Study on Magnetic Field Therapy to Improve Quality of Sleep and Reduction of Chronic Spine Pain (Sleep/Mag) Unknown status NCT00445133 Phase 4
19 Prospective, Randomized, Single Blind Trial on the Effects of Paravertebral Intramuscular Oxygen-ozone Therapy on Back Pain in Subjects Aged 65 or Older Unknown status NCT01709058 Phase 4 Intramuscular/paravertebral injections of Oxygen-Ozone
20 Evaluation of Triamcinolone's Efficacy on the Ultrasound- Guided Infiltration in the Quadratus Lumborum Syndrome: a Double Blind, Randomized, Controlled Study Unknown status NCT03407027 Phase 4 Quadratus triamcinolone;Gluteus triamcinolone;quadratus without triamcinolone.
21 Estimation of Therapeutic Effect of MDcure on Patients With Chronic Back Pain Unknown status NCT02971592 Phase 4
22 Assessment of the Effectiveness of a Program of Preparation to Pregnancy and Delivery Unknown status NCT01155804 Phase 4
23 Glucosamine Sulphate, Ginger, Ginger-Avocado-Soya and Ginger-Ibuprofen for Chronic Back Pain - a Randomized, Double Blind, Placebo-Controlled Clinical Investigation With Parallel Groups for 3 Months to Enlighten Joint Health Completed NCT00317655 Phase 4 Glucosamine sulphate;Ginger;Ginger-Avocado-Soya;Ginger-ibuprofen
24 Prospective, Randomized Study of Multicolumn Implantable Lead Stimulation for Predominant Low Back Pain Completed NCT01697358 Phase 4 Optimal Medical Management (OMM)
25 A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain. A Randomized Trial Completed NCT03861611 Phase 4 Ketorolac;Ibuprofen;Diclofenac
26 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed NCT00443781 Phase 4
27 Improvement in Pain, Function and Quality of Life With a Protocolized Exercise Program Compared With Non-steroidal Anti-inflammatory Analgesics in Patients With Subacute Low Back Pain in Medellín, Colombia, 2009-2010 Completed NCT01374269 Phase 4 NSAID (Nonsteroidal anti-inflammatory drugs)
28 Effectiveness of Abdominal Belt for the Chronic Low Back Pain Treatment Completed NCT02062918 Phase 4
29 Comparison of The Effectiveness of Intravenous Paracetamol, Dexketoprofen and Ibuprofen In The Treatment of Non-Traumatic Acute Low Back Pain In The Emergency Department Completed NCT04609254 Phase 4 Paracetamol;Dexketoprofen;Ibuprofen
30 Phase 4 Study of Glucosamine Sulphate in the Treatment for Chronic Low Back Pain Patients With Degenerative Lumbar MRI Findings Completed NCT00404079 Phase 4 Glucosamine sulphate;Placebo
31 A Randomized, Controlled, Double-Blind, Pilot Study to Evaluate Ferris PainWrap, a Semipermeable Hydrophilic Polymeric Membrane, in the Treatment of Chronic Low Back Pain Completed NCT00364065 Phase 4
32 Antibiotic Treatment to Patients With Low Back Pain Associated With Modic Changes Following Disc Herniation. A Randomized Clinical Controlled Trial Completed NCT00302796 Phase 4 Bioclavid;Placebo
33 An 8-week, Prospective, Interventional, Single-arm, Multi-centre, Phase IV Study to Evaluate the Efficacy and Safety of Controlled-release Oxycodone/Naloxone (Targin®) in Moderate to Severe Low Back Pain Patients Who Are Not Adequately Controlled by NSAIDs Completed NCT03768466 Phase 4 Brand Name: Targin®
34 Efficacy, Safety and Quality of Life Outcome of Fentanyl Transdermal Patch (Durogesic-D-Trans) Among Filipino Patients With Osteoarthritis and Chronic Low Back Pain Completed NCT01795898 Phase 4 Fentanyl
35 Avaliação clínica-terapêutica Comparativa em Lombalgias de Etiologia Traumato-compressivas Utilizando-se Vitaminas do Complexo B e nucleotídeos Completed NCT02640417 Phase 4 Nucleotides + B12;B Vitamins
36 Optimizing Outcomes in Older Adults With Low Back Pain and Depression Completed NCT00696293 Phase 4 Duloxetine
37 Efficacy Study of Caudal Epidural Steroid Injections in Patients With Low Back Pain/Radiculopathy Completed NCT01407913 Phase 4
38 Evaluation of the Effectiveness, Safety, and Tolerability of Tapentadol PR Versus a Combination of Tapentadol PR and Pregabalin in Subjects With Severe Chronic Low Back Pain With a Neuropathic Pain Component Completed NCT01352741 Phase 4 Tapentadol Prolonged Release;Tapentadol Prolonged Release with Pregabalin;Tapentadol Prolonged Release open label maintenance
39 Multicenter Randomized Controlled Trial of Epidural Steroid Injections for Spinal Stenosis in Persons 50 and Older Completed NCT01238536 Phase 4 Epidural steroid injection;Epidural local anesthetic injection
40 Randomized Double-blind Study Comparing the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component Completed NCT01166048 Phase 4 Duloxetine;Duloxetine
41 Pain Reducing Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients With Chronic Low Back Pain or Chronic Lumbo-radiculalgia and Followed in Pain Treatment Centers Completed NCT00452010 Phase 4
42 Double-blind, Placebo-controlled Study of the Safety and Efficacy of Eszopiclone in the Treatment of Insomnia in Patients With Chronic Low Back Pain Completed NCT00365976 Phase 4 Eszopiclone;Placebo
43 Effectiveness of the Precision Spinal Cord Stimulation System in Patients With Failed Back Surgery Syndrome and Axial Low Back Pain Completed NCT00205868 Phase 4
44 Evaluation of the Effectiveness, Safety, and Tolerability of Tapentadol PR Versus Oxycodone/Naloxone PR in Non-opioid Pre-treated Subjects With Uncontrolled Severe Chronic Low Back Pain With a Neuropathic Pain Component. Completed NCT01838616 Phase 4 Tapentadol Prolonged Release;Oxycodone/Naloxone Prolonged Release
45 Open Label Randomized Study for Evaluating Efficacy and Safety of Ketorolac Tromethamine and Ketoprofen in Gel in Patients With Gonarthrosis and Low Back Pain Completed NCT02638831 Phase 4 Ketorolac Tromethamine;Ketoprofen
46 Pamukkale University Medical School,Dept. of Emergency Medicine Completed NCT01422291 Phase 4 paracetamol;morphine;Dexketoprofen;Paracetamole
47 Multicentre Study To Evaluate Efficacy And Safety Of Buprenorphine Transdermal Patch (Norspan) In Chronic Non-Malignant Pain Of Moderate To Severe Intensity Due To Osteoarthritis, Rheumatoid Arthritis, Lower Back Pain And Joint / Muscle Pain, When Opioid Is Needed For Analgesia Completed NCT01961271 Phase 4 Buprenorphine transdermal patch
48 Spinal Manipulative Therapy for Low Back Pain: Randomised Controlled Trial Completed NCT00294229 Phase 4
49 Assessing Functionality Changes Associated With Patients Who Were Taking Short Acting Opioids Chronically and Who Initiated Treatment With Duragesic® (Fentanyl Transdermal System) for the Management of Chronic Low Back Pain. Completed NCT00237341 Phase 4 fentanyl
50 Evaluation Study of Efficacy and Safety of TTS-Fentanyl in Severe Chronic Low Back Pain Completed NCT01774903 Phase 4 TTS-fentanyl

Search NIH Clinical Center for Back Pain

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Genetic Tests for Back Pain

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Anatomical Context for Back Pain

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MalaCards organs/tissues related to Back Pain:

40
Spinal Cord, Bone, Bone Marrow, Dorsal Root Ganglion, Cortex, Prostate, Brain
Sources

Publications for Back Pain

About this section

Articles related to Back Pain:

(show top 50) (show all 30000)
# Title Authors PMID Year
1
Effects of progressive neuromuscular stabilization exercise on the support surface on patients with high obesity with lumbar instability: A double-blinded randomized controlled trial. 61 42
33530156 2021
2
Isokinetic training - its radiographic and inflammatory effects on chronic low back pain: A randomized controlled trial. 42 61
33371083 2020
3
Minimally Invasive Treatment for Degenerative Lumbar Spine. 42 61
33308584 2020
4
Patients' experiences of the BetterBack model of care for low back pain in primary care - a qualitative interview study. 61
33393455 2021
5
Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. 61
33275908 2021
6
The potential role and trend of HIF‑1α in intervertebral disc degeneration: Friend or foe? (Review). 61
33537810 2021
7
Factors predisposing to work-related lower back pain in automobile industry workers. 61
30246622 2021
8
Response to Letter to the Editor re Patient and public beliefs about the role of imaging in the management of non-specific low back pain: a scoping review. 61
33069368 2021
9
Early life chronic inflammatory conditions predict low back pain in adolescence and young adulthood. 61
33259645 2021
10
Current patterns of practice in spinal fusion for chronic low back pain-results from a survey at the German Spine Societies' Annual Congress 2018. 61
33404879 2021
11
Extrinsic compression of the left main coronary artery: A rare cause of cardiogenic shock. 61
33505558 2021
12
Geant adrenal myelolipoma: A case report with literature review. 61
33376675 2021
13
Lumbar Spinal Stenosis and Potential Management With Prostaglandin E1 Analogs. 61
33065578 2021
14
Validation of the Questionnaire for Symptom Assessment in Pain disorders for Back pain patients (Q-SAP). 61
33131154 2021
15
Clinical features of middle cluneal nerve entrapment neuropathy. 61
33404869 2021
16
High-frequency thermal coagulation to treat middle cluneal nerve entrapment neuropathy. 61
32415488 2021
17
Improvement of Lower Back Pain in Lumbar Spinal Stenosis After Decompression Surgery and Factors That Predict Residual Lower Back Pain. 61
32875871 2021
18
Development and validation of a daily Injustice Experience Questionnaire. 61
33259677 2021
19
Elite Athletes and Pregnancy Outcomes: A Systematic Review and Meta-analysis. 61
32925496 2021
20
A Rare Case of Nontraumatic Thoracic Compression Fracture in a 28-Year-Old Man. 61
32618750 2021
21
Will that hurt? A contingency learning task to assess pain-expectancy judgments for low back postures. 61
33129131 2021
22
Quality of life and functional outcomes with tapentadol prolonged release in chronic musculoskeletal pain: post hoc analysis. 61
33241725 2021
23
Who are the individuals with the worst perceived quality of sleep? A population-based survey in southern Brazil. 61
33489722 2021
24
Patient-Reported Outcomes Following Lumbar Decompression Surgery: A Review of 2699 Cases. 61
32875849 2021
25
The effects of exposure to microgravity and reconditioning of the lumbar multifidus and anterolateral abdominal muscles: implications for people with LBP. 61
32966906 2021
26
Multicentre randomised controlled clinical trial of electroacupuncture with usual care for patients with non-acute pain after back surgery. 61
33341226 2021
27
Conversion of Fused Hip to Total Hip Arthroplasty: Long-Term Clinical and Radiological Outcomes. 61
33082070 2021
28
Automated Grading of Lumbar Disc Degeneration Using a Push-Pull Regularization Network Based on MRI. 61
33094867 2021
29
Solitary Fibrous tumor of the lumbar spine mimicking a sequestered disc fragment. 61
33363685 2021
30
Standing working posture and musculoskeletal pain among Citrus sinensis workers in a low-income country. 61
30412040 2021
31
Patterns of Approach to Activity in 851 Patients With Severe Chronic Pain: Translation and Preliminary Validation of the 9-item Avoidance-Endurance Fast-Screen (AEFS) Into Danish. 61
33399395 2021
32
Comparative analysis of the autonomic nervous system response during movement representation in healthy individuals and patients with chronic low back pain: a prospective cohort study. 61
33153350 2021
33
Comparison of Isolated Lumbar Extension Strength in Competitive and Noncompetitive Powerlifters, and Recreationally Trained Men. 61
29979273 2021
34
Accelerated brain aging in chronic low back pain. 61
33422525 2021
35
Assessment of aerobic fitness in individuals with and without nonspecific chronic low back pain: a pilot study. 61
33136618 2021
36
The Role of Waddell Signs in Low Back Pain. 61
33591088 2021
37
Prolonged opioid use among opioid-naive individuals after prescription for nonspecific low back pain in the emergency department. 61
32947539 2021
38
Why apply kinesio taping only to the bilateral erector spinae muscles in chronic non-specific low back pain? 61
33563373 2021
39
Effect of Pain Education, Cryotherapy, and Transcutaneous Electrical Nerve Stimulation on the Pain, Functional Capacity, and Quality of Life in Patients With Nonspecific Chronic Low Back Pain: A Single-Blind Randomized Controlled Trial. 61
33595936 2021
40
The STarT Back stratified care model for nonspecific low back pain: a model-based evaluation of long-term cost-effectiveness. 61
32868748 2021
41
Letter in response to: 'Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis' by Owen et al. 61
32024645 2021
42
Editorial comment on discussion: 'Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis'. 61
33032990 2021
43
Waddell (Nonorganic) Signs and Their Association With Interventional Treatment Outcomes for Low Back Pain. 61
32701541 2021
44
Low back pain among Italian runners: A cross-sectional survey. 61
33434869 2021
45
Relationship between psychological factors and spinal motor behaviour in low back pain: a systematic review and meta-analysis. 61
33591109 2021
46
Response to Discussion: 'Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis'. 61
32522733 2021
47
Contribution of the sensory innervation of the spine in low back pain: review and clinical commentary. 61
33108934 2021
48
Effect of a Long-lasting Multidisciplinary Program on Disability and Fear-Avoidance Behaviors in Patients With Chronic Low Back Pain: Results of a Randomized Controlled Trial: Erratum. 61
33543872 2021
49
Is adding pelvic floor muscle training to an exercise intervention more effective at improving pain in patients with non-specific low back pain? A systematic review of randomized controlled trials. 61
32349867 2021
50
Letter-to-the-editor regarding Taylor S, Bishop A. Patient and public beliefs about the role of imaging in the management of non-specific low back pain: a scoping review. Physiotherapy. 2020 Jun;107:224-233. 61
32967773 2021
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Variations for Back Pain

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Expression for Back Pain

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Search GEO for disease gene expression data for Back Pain.
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Pathways for Back Pain

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Pathways related to Back Pain according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.5 IL6 IL1RN IL1B IL1A
2
Toll Comparative Pathway 63
Show member pathways
 12.1 IL6 IL1B IL1A
3
IL-1 signaling pathway 1
Show member pathways
 12.09 IL1RN IL1B IL1A
4
Tuberculosis 36
12.03 IL6 IL1B IL1A
5
Spinal Cord Injury 1
11.83 IL6 IL1B IL1A
6
Interleukin-4 and 13 signaling 65
11.79 IL6 IL1B IL1A
7
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.77 IL6 IL1RN IL1B IL1A
8
Senescence and Autophagy in Cancer 1
11.75 IL6 IL1B IL1A
9
AGE-RAGE signaling pathway in diabetic complications 36
11.71 IL6 IL1B IL1A
10
Hematopoietic cell lineage 36
11.7 IL6 IL1B IL1A
11
Rheumatoid arthritis 36
11.65 IL6 IL1B IL1A
12
Pertussis 36
11.53 IL6 IL1B IL1A
13
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.43 IL6 IL1B IL1A
14
Lung fibrosis 1
11.41 IL6 IL1B CALCA
15
Malaria 36
11.28 THBS2 IL6 IL1B
16
Hematopoietic Stem Cell Differentiation 1
11.23 IL6 IL1B IL1A
17
African trypanosomiasis 36
11.2 IL6 IL1B
18
Development and heterogeneity of the ILC family 1
11.12 IL6 IL1B
19
Antifolate resistance 36
11.1 IL6 IL1B
20
IL-10 Pathway 63
11.04 IL6 IL1B IL1A
21
Interleukin-10 signaling 65
10.95 IL6 IL1RN IL1B IL1A
22
G-protein signaling_Rap2B regulation pathway 23
10.8 IL6 IL1B IL1A COL9A3
23
Cytokines and Inflammatory Response 1
10.79 IL6 IL1B IL1A
24
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.66 IL6 IL1B
25
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.58 IL6 IL1B IL1A CALCA
26
Interleukin-1 processing 65
10.34 IL1B IL1A
Sources

GO Terms for Back Pain

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Cellular components related to Back Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 IL6 IL1RN IL1B IL1A COL9A3 CALCA
2 extracellular region GO:0005576 9.17 THBS2 IL6 IL1RN IL1B IL1A COL9A3

Biological processes related to Back Pain according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.81 IL6 IL1RN IL1B IL1A
2 cellular response to lipopolysaccharide GO:0071222 9.73 IL6 IL1B IL1A
3 cytokine-mediated signaling pathway GO:0019221 9.67 IL6 IL1RN IL1B IL1A
4 interleukin-1-mediated signaling pathway GO:0070498 9.65 IL1RN IL1B IL1A
5 positive regulation of interleukin-6 production GO:0032755 9.63 IL6 IL1B IL1A
6 acute-phase response GO:0006953 9.61 IL6 IL1RN
7 embryo implantation GO:0007566 9.61 IL1B CALCA
8 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.6 IL1B IL1A
9 positive regulation of interleukin-2 production GO:0032743 9.59 IL1B IL1A
10 positive regulation of mitotic nuclear division GO:0045840 9.58 IL1B IL1A
11 negative regulation of neurogenesis GO:0050768 9.58 IL6 IL1B
12 regulation of nitric-oxide synthase activity GO:0050999 9.57 IL1B IL1A
13 positive regulation of glial cell proliferation GO:0060252 9.55 IL6 IL1B
14 response to pain GO:0048265 9.54 COMT CALCA
15 negative regulation of bone resorption GO:0045779 9.52 IL6 CALCA
16 positive regulation of neuroinflammatory response GO:0150078 9.49 IL6 IL1B
17 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.43 IL6 IL1RN
18 positive regulation of interleukin-8 production GO:0032757 9.43 IL6 IL1B CALCA
19 vascular endothelial growth factor production GO:0010573 9.4 IL6 IL1B
20 positive regulation of immature T cell proliferation in thymus GO:0033092 9.32 IL1B IL1A
21 fever generation GO:0001660 9.16 IL1B IL1A
22 positive regulation of vascular endothelial growth factor production GO:0010575 9.13 IL6 IL1B IL1A
23 inflammatory response GO:0006954 9.02 IL6 IL1RN IL1B IL1A CALCA

Molecular functions related to Back Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IL6 IL1RN IL1B IL1A
2 interleukin-1 receptor binding GO:0005149 8.8 IL1RN IL1B IL1A
Sources

Sources for Back Pain

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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