MCID: BCT020
MIFTS: 28

Bacteremia 2

Categories: Genetic diseases

Aliases & Classifications for Bacteremia 2

MalaCards integrated aliases for Bacteremia 2:

Name: Bacteremia 2 58
Bacteremia, Susceptibility to, 2 58 30 6
Bacteremia 58 56 74
Bacteremia, Susceptibility to 58 13
Bacteremia, Susceptibility to, Type 2 41
Bacts2 58

Classifications:



External Ids:

OMIM 58 614383
UMLS 74 C0004610

Summaries for Bacteremia 2

MalaCards based summary : Bacteremia 2, also known as bacteremia, susceptibility to, 2, is related to neisseria meningitidis infection and infective endocarditis. An important gene associated with Bacteremia 2 is CISH (Cytokine Inducible SH2 Containing Protein), and among its related pathways/superpathways is Innate Immune System. Related phenotype is homeostasis/metabolism.

Wikipedia : 77 Bacteremia (also bacteraemia or septicemia) is the presence of bacteria in the blood. Blood is normally... more...

Description from OMIM: 614383

Related Diseases for Bacteremia 2

Diseases in the Bacteremia 2 family:

Bacteremia 1

Diseases related to Bacteremia 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 444)
# Related Disease Score Top Affiliating Genes
1 neisseria meningitidis infection 32.2 LACTB MBL2
2 infective endocarditis 30.7 CRP LBP
3 endocarditis 30.6 CRP LACTB LBP
4 meningitis 30.5 CRP LACTB MBL2
5 pneumonia 30.5 CRP LACTB MBL2
6 appendicitis 30.1 CRP LBP
7 reactive arthritis 29.9 BPI CRP
8 bacterial infectious disease 29.7 BPI CRP LBP MBL2
9 pelvic inflammatory disease 29.7 CRP GUSB
10 meningococcemia 29.7 BPI MBL2
11 bacterial sepsis 29.6 CRP LBP
12 bacterial pneumonia 29.5 CRP LACTB
13 diabetes mellitus 29.1 CAT CRP GCG HMGCR
14 vascular disease 28.9 CAT CRP HMGCR
15 bronchitis 28.8 CRP LACTB SLPI
16 mastitis 28.7 LBP SLPI
17 flavimonas oryzihabitans infection 11.6
18 bacteremia 1 11.5
19 erysipeloid 11.1
20 typhoidal tularemia 11.1
21 bartonellosis 11.1
22 actinobacillosis 11.1
23 cellulitis 10.4
24 leukemia 10.4
25 neutropenia 10.4
26 pyelonephritis 10.3
27 streptococcal meningitis 10.3 CRP MBL2
28 bacteriuria 10.3
29 peritonitis 10.3
30 arthritis 10.3
31 acute cystitis 10.3
32 liver cirrhosis 10.2
33 mesenteric lymphadenitis 10.2 CRP LBP
34 acquired immunodeficiency syndrome 10.2
35 septic arthritis 10.2
36 stenotrophomonas maltophilia infection 10.2
37 acalculous cholecystitis 10.2 CRP GUSB
38 haemophilus influenzae 10.2
39 acute insulin response 10.2 CRP GCG
40 hematopoietic stem cell transplantation 10.1
41 colitis 10.1
42 prediabetes syndrome 10.1 CRP GCG
43 gastroenteritis 10.1
44 agammaglobulinemia 10.1
45 cholangitis 10.1
46 osteomyelitis 10.1
47 lymphocytic leukemia 10.1
48 varicose veins 10.1
49 acute leukemia 10.1
50 esophageal varix 10.1

Comorbidity relations with Bacteremia 2 via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Ischemic Heart Disease Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Bacteremia 2:



Diseases related to Bacteremia 2

Symptoms & Phenotypes for Bacteremia 2

Clinical features from OMIM:

614383

MGI Mouse Phenotypes related to Bacteremia 2:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 CAT CISH CRP GUSB HMGCR LBP

Drugs & Therapeutics for Bacteremia 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Disease Burden of Pneumonia, Meningitis and Bacteremia Among Children in Japan: Pneumonet Japan Completed NCT00757575

Search NIH Clinical Center for Bacteremia 2

Genetic Tests for Bacteremia 2

Genetic tests related to Bacteremia 2:

# Genetic test Affiliating Genes
1 Bacteremia, Susceptibility to, 2 30 CISH

Anatomical Context for Bacteremia 2

Publications for Bacteremia 2

Variations for Bacteremia 2

ClinVar genetic disease variations for Bacteremia 2:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CISH NM_013324.5(CISH): c.-524T> A single nucleotide variant risk factor rs414171 GRCh37 Chromosome 3, 50649499: 50649499
2 CISH NM_013324.5(CISH): c.-524T> A single nucleotide variant risk factor rs414171 GRCh38 Chromosome 3, 50612068: 50612068

Expression for Bacteremia 2

Search GEO for disease gene expression data for Bacteremia 2.

Pathways for Bacteremia 2

Pathways related to Bacteremia 2 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 BPI CAT CISH CRP GUSB LBP

GO Terms for Bacteremia 2

Cellular components related to Bacteremia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 BPI CAT CRP GCG GUSB LBP
2 extracellular space GO:0005615 9.28 BPI CAT CRP GCG GUSB LBP

Biological processes related to Bacteremia 2 according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.73 CRP LBP MBL2 SLPI
2 neutrophil degranulation GO:0043312 9.71 BPI CAT GUSB SLPI
3 defense response to Gram-positive bacterium GO:0050830 9.5 CRP LBP MBL2
4 negative regulation of tumor necrosis factor production GO:0032720 9.49 BPI LBP
5 protein tetramerization GO:0051262 9.48 CAT HMGCR
6 interleukin-7-mediated signaling pathway GO:0038111 9.46 CISH SMARCA4
7 defense response to bacterium GO:0042742 9.46 BPI LBP MBL2 SLPI
8 negative regulation of growth of symbiont in host GO:0044130 9.37 LBP MBL2
9 negative regulation of blood vessel diameter GO:0097756 9.26 CRP HMGCR
10 acute-phase response GO:0006953 9.13 CRP LBP MBL2
11 opsonization GO:0008228 8.8 CRP LBP MBL2

Molecular functions related to Bacteremia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.16 CAT HMGCR
2 signaling receptor binding GO:0005102 9.02 CAT GCG GUSB LBP MBL2
3 lipopolysaccharide binding GO:0001530 8.96 BPI LBP

Sources for Bacteremia 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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