MCID: BCT020
MIFTS: 33

Bacteremia 2

Categories: Genetic diseases

Aliases & Classifications for Bacteremia 2

MalaCards integrated aliases for Bacteremia 2:

Name: Bacteremia 2 57
Bacteremia, Susceptibility to, 2 57 29 6
Bacteremia 57 55 73
Bacteremia, Susceptibility to 57 13
Bacteremia, Susceptibility to, Type 2 40
Bacts2 57

Classifications:



External Ids:

OMIM 57 614383
UMLS 73 C0004610

Summaries for Bacteremia 2

MalaCards based summary : Bacteremia 2, also known as bacteremia, susceptibility to, 2, is related to neisseria meningitidis infection and infective endocarditis. An important gene associated with Bacteremia 2 is CISH (Cytokine Inducible SH2 Containing Protein), and among its related pathways/superpathways is Innate Immune System. Affiliated tissues include lung, kidney and liver, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Bacteremia (also bacteraemia) is the presence of bacteria in the blood. Blood is normally a sterile... more...

Description from OMIM: 614383

Related Diseases for Bacteremia 2

Diseases in the Bacteremia 2 family:

Bacteremia 1

Diseases related to Bacteremia 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 400)
# Related Disease Score Top Affiliating Genes
1 neisseria meningitidis infection 32.1 LACTB MBL2
2 infective endocarditis 30.4 CRP LBP
3 endocarditis 30.4 CRP LACTB LBP
4 meningitis 30.3 CRP LACTB MBL2
5 pneumonia 30.3 CRP LACTB MBL2
6 appendicitis 29.8 CRP LBP
7 reactive arthritis 29.7 BPI CRP
8 bacterial pneumonia 29.6 CRP LACTB
9 meningococcemia 29.5 BPI MBL2
10 bacterial sepsis 29.5 CRP LBP
11 bacterial infectious disease 29.4 BPI CRP LBP MBL2
12 diabetes mellitus 29.1 CAT CRP GCG HMGCR
13 vascular disease 29.0 CAT CRP HMGCR
14 flavimonas oryzihabitans infection 11.6
15 bacteremia 1 11.5
16 erysipeloid 11.0
17 typhoidal tularemia 11.0
18 bartonellosis 11.0
19 actinobacillosis 11.0
20 neutropenia 10.3
21 leukemia 10.2
22 cellulitis 10.2
23 pyelonephritis 10.2
24 bacteriuria 10.2
25 stenotrophomonas maltophilia infection 10.2
26 streptococcal meningitis 10.2 CRP MBL2
27 peritonitis 10.2
28 mesenteric lymphadenitis 10.1 CRP LBP
29 liver cirrhosis 10.1
30 acute cystitis 10.1
31 agammaglobulinemia 10.1
32 acalculous cholecystitis 10.1 CRP GUSB
33 acute insulin response 10.1 CRP GCG
34 arthritis 10.1
35 cholangitis 10.1
36 prediabetes syndrome 10.1 CRP GCG
37 colitis 10.1
38 lymphocytic leukemia 10.1
39 hematopoietic stem cell transplantation 10.0
40 esophageal varix 10.0
41 ecthyma 10.0
42 cholecystitis 10.0
43 acute pyelonephritis 10.0
44 acquired immunodeficiency syndrome 10.0
45 granulocytopenia 10.0
46 haemophilus influenzae 10.0
47 agammaglobulinemia, x-linked 10.0
48 osteomyelitis 10.0
49 toxic shock syndrome 10.0
50 sickle cell disease 10.0

Comorbidity relations with Bacteremia 2 via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Chronic Kidney Failure
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Ischemic Heart Disease Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Bacteremia 2:



Diseases related to Bacteremia 2

Symptoms & Phenotypes for Bacteremia 2

Clinical features from OMIM:

614383

MGI Mouse Phenotypes related to Bacteremia 2:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 CAT CISH CRP GUSB HMGCR LBP

Drugs & Therapeutics for Bacteremia 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Disease Burden of Pneumonia, Meningitis and Bacteremia Among Children in Japan: Pneumonet Japan Completed NCT00757575

Search NIH Clinical Center for Bacteremia 2

Genetic Tests for Bacteremia 2

Genetic tests related to Bacteremia 2:

# Genetic test Affiliating Genes
1 Bacteremia, Susceptibility to, 2 29 CISH

Anatomical Context for Bacteremia 2

MalaCards organs/tissues related to Bacteremia 2:

41
Lung, Kidney, Liver, Colon, Heart, T Cells, Myeloid

Publications for Bacteremia 2

Variations for Bacteremia 2

ClinVar genetic disease variations for Bacteremia 2:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CISH NM_013324.5(CISH): c.-524T> A single nucleotide variant risk factor rs414171 GRCh37 Chromosome 3, 50649499: 50649499
2 CISH NM_013324.5(CISH): c.-524T> A single nucleotide variant risk factor rs414171 GRCh38 Chromosome 3, 50612068: 50612068

Expression for Bacteremia 2

Search GEO for disease gene expression data for Bacteremia 2.

Pathways for Bacteremia 2

Pathways related to Bacteremia 2 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 BPI CAT CISH CRP GUSB LBP

GO Terms for Bacteremia 2

Cellular components related to Bacteremia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 BPI CAT CRP GCG GUSB LBP
2 extracellular space GO:0005615 9.28 BPI CAT CRP GCG GUSB LBP

Biological processes related to Bacteremia 2 according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.73 CRP LBP MBL2 SLPI
2 neutrophil degranulation GO:0043312 9.71 BPI CAT GUSB SLPI
3 defense response to Gram-positive bacterium GO:0050830 9.5 CRP LBP MBL2
4 negative regulation of tumor necrosis factor production GO:0032720 9.49 BPI LBP
5 protein tetramerization GO:0051262 9.48 CAT HMGCR
6 interleukin-7-mediated signaling pathway GO:0038111 9.46 CISH SMARCA4
7 defense response to bacterium GO:0042742 9.46 BPI LBP MBL2 SLPI
8 negative regulation of growth of symbiont in host GO:0044130 9.37 LBP MBL2
9 negative regulation of blood vessel diameter GO:0097756 9.26 CRP HMGCR
10 acute-phase response GO:0006953 9.13 CRP LBP MBL2
11 opsonization GO:0008228 8.8 CRP LBP MBL2

Molecular functions related to Bacteremia 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NADP binding GO:0050661 9.16 CAT HMGCR
2 signaling receptor binding GO:0005102 9.02 CAT GCG GUSB LBP MBL2
3 lipopolysaccharide binding GO:0001530 8.96 BPI LBP

Sources for Bacteremia 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....