Bacterial Infectious Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BCT022 MIFTS: 53	Bacterial Infectious Disease Categories: Infectious diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Bacterial Infectious Disease

MalaCards integrated aliases for Bacterial Infectious Disease:

Name: Bacterial Infectious Disease ¹¹ ¹⁴

Bacterial Disease or Disorder ³³

Disease Caused by Bacteria ³³

Bacterial Infection Nos ³³

Bacterial Infections ⁴³

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Certain infectious and parasitic diseases

Other bacterial diseases

Bacterial infection of unspecified site

Bacterial infection, unspecified

ICD11: ³³

Certain infectious or parasitic diseases

Other bacterial diseases

Bacterial infection of unspecified site

External Ids:

Disease Ontology ¹¹ DOID:104

MeSH ⁴³ D001424

NCIt ⁴⁹ C2890

SNOMED-CT ⁶⁸ 87628006

ICD10 ³¹ A49 A49.9

ICD11 ³³ 520429137

UMLS ⁷¹ C0004623

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Summaries for Bacterial Infectious Disease

Disease Ontology: ¹¹ A disease by infectious agent that results in infection, has material basis in Bacteria.

MalaCards based summary: Bacterial Infectious Disease, also known as bacterial disease or disorder, is related to commensal bacterial infectious disease and primary bacterial infectious disease. An important gene associated with Bacterial Infectious Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are ERK Signaling and Disease. The drugs Esomeprazole and Cephalexin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and eye, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Bacterial Infectious Disease

Diseases related to Bacterial Infectious Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1319)

#	Related Disease	Score	Top Affiliating Genes
1	commensal bacterial infectious disease	33.1	TNF TLR4 TLR2 MYD88 IL6 IL1B
2	primary bacterial infectious disease	33.1	TNF TLR4 TLR2 NOD2 MYD88 IL6
3	actinomycosis	32.7	TNF IL10 CRP
4	listeriosis	32.7	TNF TLR2 MYD88 IL6 IL1B IL10
5	tularemia	32.7	TNF TLR4 TLR2 MYD88 IL6 IL1B
6	endocarditis	32.6	TNF TLR2 IL6 IL17A IL10 IFNG
7	sickle cell anemia	32.6	TNF IL6 CSF3 CRP
8	bacterial meningitis	32.5	TNF TLR4 TLR2 IL1B IL10 CXCL8
9	leukocyte adhesion deficiency, type i	32.5	IL17A CSF3 CCR6
10	paratyphoid fever	32.5	TNF IL1B IFNG CRP
11	infective endocarditis	32.5	IL6 CXCL8 CRP CCR6
12	leptospirosis	32.5	TNF TLR2 IL6 IL1B IL10 IFNG
13	lyme disease	32.5	TNF TLR2 IL6 IL1B IL17A CRP
14	typhoid fever	32.5	TNF TLR4 IL6 IL1B IFNG CRP
15	tetanus	32.5	TNF IL6 IL1B IL10 IFNG CRP
16	trachoma	32.5	TNF IL6 IL17A IL10
17	legionellosis	32.5	TNF TLR4 TLR2 NOD1 MYD88 IL6
18	syphilis	32.5	TNF TLR2 IL17A CRP CCR6
19	brucellosis	32.5	TNF TLR4 IL6 IL17A IL10 IFNG
20	cholera	32.5	TNF IL6 IL1B IL10 IFNG CXCL8
21	neutropenia	32.5	TNF TLR4 IL6 IL1B IL10 IFNG
22	melioidosis	32.5	TNF TLR4 TLR2 NOD2 IL6 IL10
23	common variable immunodeficiency	32.5	TNF TLR2 NOD2 IL6 IL1B IL10
24	severe congenital neutropenia 3	32.5	ELANE CSF3 CAMP
25	plague	32.5	TNF TLR4 TLR2 MYD88 IL6 IL1B
26	gas gangrene	32.5	TNF IL6 CRP
27	shigellosis	32.5	IL1B IL10 DEFB1 CCR6 CAMP
28	severe congenital neutropenia	32.4	TNF ELANE CSF3 CAMP
29	macs syndrome	32.4	TNF IL10 IFNG
30	q fever	32.4	TNF TLR4 TLR2 NOD2 MYD88 IL6
31	whim syndrome 1	32.4	ELANE CSF3 CCR6
32	toxic shock syndrome	32.4	TNF TLR4 TLR2 IL6 IL1B IL10
33	bacterial sepsis	32.4	TNF TLR4 TLR2 MYD88 IL6 IL1B
34	chlamydia	32.4	TNF TLR4 TLR2 NOD1 IL6 IL1B
35	tonsillitis	32.4	TNF TLR4 TLR2 IL6 IL1B IL10
36	neutropenia, severe congenital, 3, autosomal recessive	32.4	ELANE CSF3
37	leprosy 3	32.4	TNF TLR4 TLR2 NOD2 IL6 IL1B
38	common cold	32.4	TNF IL6 IL1B IL17A IL10 CXCL8
39	blepharitis	32.4	TNF IL6 IL1B IL17A CXCL8 CCR6
40	mycobacterium tuberculosis 1	32.4	TNF TLR4 TLR2 NOD2 MYD88 IL6
41	salmonellosis	32.3	TNF TLR4 TLR2 NOD2 NOD1 MYD88
42	severe cutaneous adverse reaction	32.3	TNF IL6 IFNG CRP CCR6
43	chronic granulomatous disease	32.3	TNF IL1B IFNG CSF3
44	pyoderma	32.3	TNF NOD2 IL1B IL17A CXCL8 CSF3
45	urinary tract infection	32.3	TNF TLR4 TLR2 IL6 IL1B IL10
46	acute proliferative glomerulonephritis	32.3	TNF IL1B IL17A CRP CCR6
47	inflammatory diarrhea	32.3	IL1B IL17A IL10 CXCL8
48	pyoderma gangrenosum	32.3	TNF NOD2 IL1B CXCL8 CSF3 CCR6
49	cystic fibrosis	32.2	TNF TLR4 TLR2 NOD2 MYD88 IL6
50	hyper ige syndrome	32.2	TLR4 TLR2 IL6 IL17A IL10 IFNG

Graphical network of the top 20 diseases related to Bacterial Infectious Disease:

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Symptoms & Phenotypes for Bacterial Infectious Disease

GenomeRNAi Phenotypes related to Bacterial Infectious Disease according to GeneCards Suite gene sharing:

²⁵ (show all 26)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	10.33	CXCL8 IL10 IL17A IL1B MYD88 NOD1
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	10.33	CXCL8 IL10 IL17A IL1B MYD88 NOD1
3	no effect	GR00402-S-1	10.17	CAMP CCR6 CRP CSF3 CXCL8 DEFB1
4	no effect	GR00402-S-2	10.17	CAMP CCR6 CRP CSF3 DEFB1 DEFB4A
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-100	10.05	IL10
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-113	10.05	IL10
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-120	10.05	CRP
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-125	10.05	IL10
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-128	10.05	TLR4
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-147	10.05	CRP
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-148	10.05	CRP
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	10.05	IL10
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	10.05	CRP IL10
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	10.05	IL10
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-210	10.05	IL10 NOD2
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.05	IL10
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-22	10.05	TLR4
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-36	10.05	NOD2
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-52	10.05	IL10
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-53	10.05	IL10
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.05	CRP
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-65	10.05	IL10
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-67	10.05	IL10
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-68	10.05	IL10 TLR4
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-82	10.05	IL10
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.05	IL10

MGI Mouse Phenotypes related to Bacterial Infectious Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10.3	CAMP CCR6 CRP CSF3 DEFB1 DEFB4A
2	homeostasis/metabolism	MP:0005376	10.25	CCR6 CRP ELANE IFNG IL10 IL17A
3	neoplasm	MP:0002006	10.11	ELANE IFNG IL10 IL1B IL6 MYD88
4	liver/biliary system	MP:0005370	10.03	IFNG IL10 IL17A IL6 MYD88 TLR2
5	digestive/alimentary	MP:0005381	10.02	IFNG IL10 IL17A IL6 MYD88 NOD2
6	hematopoietic system	MP:0005397	9.89	CAMP CCR6 CSF3 DEFB4A ELANE IFNG
7	respiratory system	MP:0005388	9.86	IFNG IL10 IL17A IL6 MYD88 TLR2
8	skeleton	MP:0005390	9.85	IFNG IL10 IL17A IL1B IL6 MYD88
9	integument	MP:0010771	9.36	CSF3 ELANE IFNG IL10 IL17A IL1B

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Drugs & Therapeutics for Bacterial Infectious Disease

Drugs for Bacterial Infectious Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 365)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Esomeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6, 119141-88-7

9568614 4594

Cephalexin

Approved, Investigational, Vet_approved

Phase 4

15686-71-2

27447

Roxithromycin

Approved, Investigational, Withdrawn

Phase 4

80214-83-1

6915744

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

581 12035

Colistin

Approved

Phase 4

1264-72-8, 1066-17-7

5311054

Fluconazole

Approved, Investigational

Phase 4

86386-73-4

3365

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Metronidazole

Approved

Phase 4

443-48-1, 69198-10-3

4173

Caspofungin

Approved

Phase 4

179463-17-3, 162808-62-0

2826718

Polymyxin B

Approved, Vet_approved

Phase 4

1405-20-5, 1404-26-8

4868

Minocycline

Approved, Investigational

Phase 4

10118-90-8, 13614-98-7

54675783 5281021

Doripenem

Approved, Investigational

Phase 4

148016-81-3

73303

Azithromycin

Approved

Phase 4

83905-01-5

447043

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Chlorhexidine

Approved, Vet_approved, Withdrawn

Phase 4

55-56-1

2713 9552079

Tetracycline

Approved, Vet_approved, Withdrawn

Phase 4

60-54-8

5353990

Clarithromycin

Approved

Phase 4

81103-11-9

84029

Rabeprazole

Approved, Investigational

Phase 4

117976-89-3, 117976-90-6

5029

Doxycycline

Approved, Investigational, Vet_approved

Phase 4

564-25-0

54671203

Cefadroxil

Approved, Vet_approved, Withdrawn

Phase 4

66592-87-8, 50370-12-2

47965

Clindamycin

Approved, Vet_approved

Phase 4

18323-44-9, 24729-96-2

29029

Retapamulin

Approved

Phase 4

224452-66-8

6918462

Carbamide peroxide

Approved

Phase 4

124-43-6

Sodium citrate

Approved, Investigational

Phase 4

68-04-2

23431961

Histamine

Approved, Investigational

Phase 4

51-45-6

774

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Acetylsalicylic acid

Approved, Vet_approved

Phase 4

50-78-2

2244

Dexlansoprazole

Approved, Investigational

Phase 4

138530-94-6

9578005

Lansoprazole

Approved, Investigational

Phase 4

103577-45-3

3883

Tazobactam

Approved

Phase 4

89786-04-9

123630

Ceftazidime

Approved

Phase 4

78439-06-2, 72558-82-8

5481173

Meropenem

Approved, Investigational

Phase 4

119478-56-7, 96036-03-2

441130

Piperacillin

Approved

Phase 4

66258-76-2

43672

Iodine

Approved, Investigational

Phase 4

7553-56-2

807

Povidone-iodine

Approved

Phase 4

25655-41-8

Povidone K30

Approved, Experimental, Withdrawn

Phase 4

9003-39-8

6917 131751496

Mupirocin

Approved, Investigational, Vet_approved

Phase 4

12650-69-0

446596

Cefazolin

Approved

Phase 4

25953-19-9

33255

Dimercaprol

Approved

Phase 4

59-52-9

3080

Telavancin

Approved

Phase 4

372151-71-8

21014972 3081362

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Norgestimate

Approved, Investigational

Phase 4

35189-28-7

6540478

Clavulanic acid

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 4

77-92-9

311

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Interventional clinical trials:

(show top 50) (show all 564)

#	Name	Status	NCT ID	Phase	Drugs
1	Clinical and Microbiological Efficacy and Mortality of a Loading Dose of Colistin in Critical Ill Patients	Unknown status	NCT02117986	Phase 4	colistin
2	Effect of Intermittent Infusion Versus Continuous Infusion of Vancomycin on Kidney Failure in Critically Ill Patients: Randomized and Controlled Multicenter Clinical Trial.	Unknown status	NCT03438214	Phase 4	Vancomycin Continuous infusion;Vancomycin Intermittent infusion
3	Bacterial Infections Associated With Healthcare (Healthcare-Associated) in Hospitalized Cirrhotic Patients: Randomized Study of Use of Traditional Empirical Antibiotic Therapy and Second-line Targeted at Multi-resistant Bacteria	Unknown status	NCT01820026	Phase 4	Imipenem;Vancomycin;azithromycin;Cefotaxime;Amoxicillin
4	An Open-label, Randomized Equivalence Trial and Cost-effectiveness Analysis of Ertapenem Versus Other Carbapenems for Treatment of Extended -Spectrum Beta-Lactamase (ESBL)-Producing Gram-negative Bacterial Infections	Unknown status	NCT01297842	Phase 4	Ertapenem;Meropenem or Imipenem
5	Effectiveness of a Hydrophobic Dressing for Microorganisms' Colonization and Infection Control of Vascular Ulcers: An Open, Controlled, Randomized Study, With Blinded Endpoint (PROBE Trial): CUCO-UV Study	Unknown status	NCT03667937	Phase 4
6	Plasma Concentrations of Amoxicillin Administered in High-doses During the First Week of Treatment : Intra- and Inter-individual Variability, Factors Associated With Overdose and Adverse Events	Unknown status	NCT04070469	Phase 4	Amoxicillin
7	High Dose Dual Therapy (HDDT) for Eradication of Helicobacter Pylori Infection	Unknown status	NCT02553083	Phase 4	Nexium 40 mg;amoxicillin 1.5 gr;doxycycline 200 mg;Nexium 20 mg;clarythromicin 500 mg;amoxicillin 1gr
8	Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome	Unknown status	NCT03148444	Phase 4	cefalexin 500 mg qid or roxithromycin 150 mg bid
9	Increased Second-line Eradication Rate of Helicobacter Pylori by Adding N-acetylcystein or Metronidazole to the Conventional Triple Therapy.	Unknown status	NCT01572597	Phase 4	10RAC+acetylcystein;10RAC+metronidazole
10	Phase 4 Randomized Multicentric Controlled Study on Impact of Continuous Venovenous Hemofiltration on Organ Failure at the Early Phase of Severe Sepsis	Completed	NCT00406198	Phase 4
11	Safety of Fluconazole Treatment of Premature and Full-term Newborn Infants - A Study on Interactions by Nonsteroidal Anti Inflammatory Drugs (NSAIDs) With Fluconazole in Respect of Pharmacodynamic Endpoints With Urinary Excretion of Vasoactive Endobiotics	Completed	NCT02079298	Phase 4	Treatment with fluconazole.;2. Treatment with both fluconazole and Ibuprofen.;3. Treatment with ibuprofen.
12	Pharmacokinetics of Caspofungin After One Dose in Patients With Liver Failure	Completed	NCT01968395	Phase 4	Caspofungin 70 mg
13	A Clinical Pharmacokinetic Study: Is Three Times Weekly Temocillin Appropriate for the Treatment of Severe Gram-negative Infections in Patients With ESRD Treated With Intermittent Hemodialysis?	Completed	NCT02285075	Phase 4	temocillin PK/PD in haemodialysis
14	Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infections	Completed	NCT03397914	Phase 4	Colistimethate Sodium
15	Time To Efficacy and Onset Of Action Of Linezolid In Skin and Soft Tissue Infections	Completed	NCT00147511	Phase 4	linezolid
16	Dispositivo Adsorbente Con Polymyxina B Immobilizzata Nello Shock Settico - Studio Clinico Randomizzato e Prospettico, Multicentrico	Completed	NCT00629382	Phase 4
17	Multicenter Open-label RCT to Compare Colistin Alone vs. Colistin Plus Meropenem	Completed	NCT01732250	Phase 4	Colistin;Meropenem
18	Extended-infusion Piperacillin-Tazobactam Versus Intermittent-Infusion Dosing Strategy in Critically Ill Patients With Suspected or Confirmed Bacterial Infections.	Completed	NCT04895657	Phase 4	Piperacillin/Tazobactam Continuous infusion;Piperacillin/Tazobactam Intermittent infusion
19	Intravenous to Oral Antibiotic Switch Therapy for Probable Neonatal Bacterial Infections: Clinical Efficacy, Safety and Cost-effectiveness	Completed	NCT03247920	Phase 4	Amoxicillin Clavulanate;Antibiotics
20	Association of Antibiotic Utilization Measures and Control of Extended-Spectrum β-Lactamases (ESBLs) Producing Bacteria	Completed	NCT00488189	Phase 4	Tazocin (pipercillin/tazobactam)
21	An Individually Randomised Trial of Rapid Diagnostic Tests in Rural Ghana	Completed	NCT00493922	Phase 4
22	Randomized, Multi-Center, Comparative Trial of Short-Course Empiric Antibiotic Therapy Versus Standard Antibiotic Therapy for Subjects With Pulmonary Infiltrates in the Intensive Care Unit (ICU)	Completed	NCT00410527	Phase 4	Merrem
23	Skin Disinfection With Octenidine Dihydrochloride for the Prevention of Catheter-Associated Infections - A Double-Blind, Randomized, Controlled Trial	Completed	NCT00515151	Phase 4	0.1% Octenidine with 30% 1-propanol and 45% 2-propanol;74% Ethanol with 10% 2-propanol
24	Association of Antibiotic Utilization Measures and Control of ESBLs Producing Bacteria	Completed	NCT00478855	Phase 4	Tazocin (Piperacillin/Tazobactem)
25	Pharmacokinetics of Colistin in Critically-ill Patients With Acute Kidney Injury Who Receive Sustained Low-Efficiency Dialysis	Completed	NCT05586438	Phase 4	Colistin Sulfomethate
26	A Post Marketing Surveillance Study on the Safety and Effectiveness of Doripenem in the Therapy of Thai Patients With Nosocomial Pneumonia, Complicated Intra-Abdominal Infections and Complicated Urinary Tract Infections	Completed	NCT00965848	Phase 4	Doripenem
27	A Single-Center, Open-Label, Randomized Study of the Pharmacokinetics of AzaSite Ophthalmic Solution Versus Vigamox in the Conjunctiva of Healthy Volunteers Following a Single Ocular Administration	Completed	NCT00564447	Phase 4	Azithromycin;Moxifloxacin
28	Randomized, Open-label, Comparative Study of Zosyn (Pip/Tazo [12g/1.5g]) Administered by Daily 24hr Continuous Infusion vs Zosyn (Pip/Tazo) [3g/0.375g]) q6h for the Treatment of Hospitalized Patients With Complicated Intra-abdominal Infection	Completed	NCT00044928	Phase 4	Piperacillin/Tazobactam
29	Peri-implantitis - Regenerative Treatment With Enamel Matrix Derivative (EMD). Clinical Effects, Microbial Profiles and Molecular Mechanisms. A Randomised Controlled Pilot Study.	Completed	NCT02500654	Phase 4
30	An Open Observational Study For The Rabeprazole Administration In Adult Subjects With Helicobacter Pylori (H. Pylori) Infection	Completed	NCT00216450	Phase 4	rabeprazole sodium
31	A Multi-Center, Open-Label, Randomized Study of the Pharmacokinetics of Azithromycin Versus Moxifloxacin in Conjunctiva and Aqueous Humor Following Single or Multiple Ocular Administration of AzaSite Ophthalmic Solution, 1% or Vigamox in Subjects Undergoing Routine Cataract Surgery	Completed	NCT00575380	Phase 4	AzaSite Eye Drops;Vigamox Eye Drops
32	A Single-Center, Open-Label, Randomized Study of the Pharmacokinetics of AzaSite Ophthalmic Solution Versus Vigamox in the Tears of Healthy Volunteers Following a Single Ocular Administration	Completed	NCT00575367	Phase 4	AzaSite (azithromycin ophthalmic solution);Vigamox (moxifloxacin hydrochloride ophthalmic solution)
33	Development of a New Critical Pathway for Treatment of Acute Bacterial Skin and Skin Structure Infections	Completed	NCT03233438	Phase 4	Dalbavancin;Usual Care
34	A Randomized Controlled Trial of Triple Therapy Versus Sequential Therapy Versus Concomitant Therapy as First Line Treatment for Helicobacter Pylori Infection	Completed	NCT02092506	Phase 4	10 day triple therapy;10 day sequential therapy;10 day concomitant therapy
35	An Open-Label, Non-Comparative Study to Assess the Pharmacokinetics, Safety and Efficacy of Topical Retapamulin (SB-275833) Ointment, 1%, Twice Daily for Five Days in the Treatment of Uncomplicated Skin and Skin Structure Infections in Pediatric Subjects Aged 2 to 24 Months	Completed	NCT00555061	Phase 4	Retapamulin Ointment, 1%
36	Comparison of Amukin Versus Biseptine Use for Dressing Application of Epicutaneocavous Catheters for Nosocomial Infection Prevention	Completed	NCT00389558	Phase 4
37	Leukocyte Depletion of Autologous Whole Blood: Impact on Perioperative Infection Rate and Length of Hospital Stay for Hip Arthroplasty Patients	Completed	NCT00176124	Phase 4
38	An Open-Label, Two-Treatment, Two-Period, Randomized Cross-Over Study To Assess The Bioequivalence Between Commercial Doxycycline Carragenate And Monohydrate Tablet Formulations In Normal Healthy Male Subjects	Completed	NCT00939562	Phase 4	doxycycline monohydrate tablet;doxycycline carragenate tablet
39	A Phase IV Open-Label Pharmacokinetic Study of Minocycline for Injection Following a Single Infusion in Critically-Ill Adults (ACUMIN)	Completed	NCT03369951	Phase 4	Minocycline
40	A Single Site Prospective Randomized Controlled Trial Comparing Chlorhexidine Gluconate and Povidone-Iodine as Vaginal Preparation Antiseptics for Cesarean Section to Determine Effect on Bacterial Load	Completed	NCT03133312	Phase 4	Chlorhexidine Gluconate;Povidone-Iodine Scrub and Paint
41	A Randomized, Open-label Study to Evaluate the Immunogenicity of Anthrax Vaccine Adsorbed Alone or Concomitantly With Raxibacumab (GSK3068483)	Completed	NCT02339155	Phase 4	Diphenhydramine
42	Saccharomyces Boulardii in the Prevention of Antibiotic-associated Diarrhea in Hospitalized Adult Patients With Lower Respiratory Tract Infections	Completed	NCT05261152	Phase 4	drug product: capsules are containing S. boulardii, administered twice daily (250 mg)
43	Steroids for Corneal Ulcers Trial	Completed	NCT00324168	Phase 4	Antibiotics;Topical corticosteroid;Placebo
44	Association of Antibiotic Utilization Measures and Control of Extended-spectrum-lactamases (ESBLs)	Completed	NCT00254696	Phase 4	Extended-Spectrum-Lactamases (ESBLs)
45	A Prospective, Multi-Center, Open-Label Study to Compare the POCone® With the UBiT®-IR300 in Measurement of 13CO2/12CO2 Ratio in Breath Samples Collected From Pediatric Subjects Ages 3 to 17 Years With Upper Gastrointestinal Signs and Symptoms	Completed	NCT01623154	Phase 4
46	Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction	Completed	NCT01244698	Phase 4	Cefadroxil discontinued early;Cefadroxil until drain removal
47	Helicobacter Eradication to Prevent Ulcer Bleeding in Aspirin Users: a Large Simple Randomised Controlled Trial	Completed	NCT01506986	Phase 4	Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg;Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
48	A Study Comparing Prospective Use of Imipenem/Cilastatin/Relebactam (IMI/REL) to Retrospective Data Using Meropenem/ Vabobactam (MVB) and Ceftazidime/Avibactam (CZA) in Treatment of Klebsiella Producing Carbapenemase Enterobacteriaceae Infections	Recruiting	NCT04785924	Phase 4	Imipenem+Relebactam
49	Short Course Antibiotic Treatment of Gram-negative Bacteremia: A Multicenter, Randomized, Non-blinded, Non-inferiority Interventional Study	Recruiting	NCT04291768	Phase 4
50	Piperacillin Tazobactam Versus Meropenem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae- a Non-inferiority Randomized Controlled Trial	Recruiting	NCT03671967	Phase 4	Piperacillin/tazobactam;Meropenem

Search NIH Clinical Center for Bacterial Infectious Disease

Cochrane evidence based reviews: bacterial infections

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Genetic Tests for Bacterial Infectious Disease

Sources

Anatomical Context for Bacterial Infectious Disease

Organs/tissues related to Bacterial Infectious Disease:

MalaCards : Skin, Lung, Eye, Neutrophil, Liver, Whole Blood, Kidney

Sources

Publications for Bacterial Infectious Disease

Articles related to Bacterial Infectious Disease:

(show top 50) (show all 910)

#	Title	Authors	PMID	Year
1	Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. ⁵³ ⁶²	Hernandez M...Wasserman SI	18986247	2008
2	Multicenter prospective study of procalcitonin as an indicator of sepsis. ⁵³ ⁶²	Aikawa N...Satomura S	15990980	2005
3	Cytokine and cytokine receptor polymorphisms in infectious disease. ⁵³ ⁶²	van Deventer SJ	10786965	2000
4	Advances of Mesenchymal Stem Cells Released Extracellular Vesicles in Periodontal Bone Remodeling. ⁶²	Liu C...Han G	36315196	2022
5	Canine brucellosis due to Brucella canis: description of the disease and control measures. ⁶²	De Massis F...Tittarelli M	35766163	2022
6	Immunoprotective role of aloin and disease resistance in Labeo rohita, infected with bacterial fish pathogen, Aeromonas hydrophila. ⁶²	Srivastava A...Mittal AK	36427124	2022
7	[A Case of Oropharyngeal Tularemia Mimicking Lymphoma During Pregnancy]. ⁶²	Elaldi N...Buyuktuna SA	36458719	2022
8	Biological Roles of Fibroblasts in Periodontal Diseases. ⁶²	Naruishi K	36359741	2022
9	Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease. ⁶²	Kikuchi T...Mitani A	36294882	2022
10	Therapeutic Potential of Antimicrobial Peptide PN5 against Multidrug-Resistant E. coli and Anti-Inflammatory Activity in a Septic Mouse Model. ⁶²	Kang DD...Park Y	36129300	2022
11	Description and validation of a new set of PCR markers predictive of avian pathogenic Escherichia coli virulence. ⁶²	Lucas C...Kempf I	35961274	2022
12	Epidemiology of scrub typhus in a tertiary care hospital of Southern Odisha: a cross sectional study. ⁶²	Panigrahi A...Parida B	36192256	2022
13	Genotyping Helicobacter pylori and fgf7 gene expression in gastric cancer. ⁶²	Hedayati MA...Bashiri H	35799083	2022
14	Pharmacokinetics of danofloxacin in freshwater crocodiles (Crocodylus siamensis) after intramuscular injection. ⁶²	Poapolathep S...Poapolathep A	35582881	2022
15	Pharmacokinetic characteristics of danofloxacin in green sea (Chelonia mydas) and hawksbill sea (Eretmochelys imbricata) turtles. ⁶²	Wanmad W...Poapolathep S	35332549	2022
16	What is the evidence base of used aggregated antibiotic resistance percentages to change empirical antibiotic treatment? A scoping review. ⁶²	Auzin A...Wertheim H	34906718	2022
17	A Deep Modality-Specific Ensemble for Improving Pneumonia Detection in Chest X-rays. ⁶²	Rajaraman S...Antani SK	35741252	2022
18	Infection and seroprevalence of Borrelia persica in domestic cats and dogs in Israel. ⁶²	Baneth G...Nachum-Biala Y	35534871	2022
19	Cytopathological and bacteriological studies on caseous lymphadenitis in cattle slaughtered at Bishoftu municipal abattoir, Ethiopia. ⁶²	Mathewos M...Fesseha H	35120279	2022
20	First-degree atrioventricular block in 14-year-old child due to Lyme disease. ⁶²	Lytvyn H...Avramenko I	35544637	2022
21	Identifying potential natural inhibitors of Brucella melitensis Methionyl-tRNA synthetase through an in-silico approach. ⁶²	Rowaiye AB...Usman HB	35312681	2022
22	Detection of Leptospira interrogans in Wild Sambar Deer (Rusa unicolor), Brazil. ⁶²	Paz LN...Pinna MH	35182280	2022
23	The evolving story of Borrelia burgdorferi sensu lato transmission in Europe. ⁶²	Steinbrink A...Klimpel S	35122516	2022
24	Identifying chemolithotrophic and pathogenic-related gene expression within suspended sediment flocs in freshwater environments: A metatranscriptomic assessment. ⁶²	VanMensel D...Weisener CG	34656597	2022
25	Prediction of Immune Infiltration Diagnostic Gene Biomarkers in Kawasaki Disease. ⁶²	Ba H...Qin Y	35755167	2022
26	All trans retinoic acid as a host-directed immunotherapy for tuberculosis. ⁶²	Bahlool AZ...O'Sullivan MP	35496824	2022
27	High-Throughput Sequencing Investigation of Bacterial Diversity in Chronic Suppurative Otitis Media and Middle Ear Cholesteatoma. ⁶²	Cheng X...Gu X	36193141	2022
28	A versatile isothermal amplification assay for the detection of leptospires from various sample types. ⁶²	Othman S...Chee HY	35291487	2022
29	Comparison of the biomechanical differences in the occlusal movement of wild-type and BMP9 knockout mice with apical periodontitis. ⁶²	Peng M...Huang E	36324890	2022
30	Binding properties of the anti-TB drugs bedaquiline and TBAJ-876 to a mycobacterial F-ATP synthase. ⁶²	Krah A...Bond PJ	36186842	2022
31	Antibacterial and antioxidant effect of ethanol extracts of Terminalia chebula on Streptococcus mutans. ⁶²	Nam YJ...Hwang YS	34184430	2021
32	Biomacromolecules of chitosan - Bacopa saponin based LipL32 gene delivery system for leptospirosis therapy. ⁶²	Govindan P...Pugazhendhi A	34273371	2021
33	Tuberculosis, an unusual source - a case report. ⁶²	Roque AL...Fonnegra JC	35733548	2021
34	A Case of Whipple Disease With Cutaneous Manifestations. ⁶²	Borretta L...Pasternak S	33606378	2021
35	Phlegmonous gastritis developed during chemotherapy for acute lymphocytic leukemia: A case report. ⁶²	Saito M...Tanikawa S	34435017	2021
36	The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis. ⁶²	Hosseini R...Schaaf MJM	33559740	2021
37	A novel Vancomycin-Functionalized-Magnetic Graphene Composite for Use as a Near-Infrared-Induced Synergistic Chemo-Photothermal Antibacterial. ⁶²	Zhang W...Liu Y	33984161	2021
38	Adaptation of gltA and ssrA assays for diversity profiling by Illumina sequencing to identify Bartonella henselae, B. clarridgeiae and B. koehlerae. ⁶²	Power RI...Slapeta J	34296984	2021
39	The RyfA small RNA regulates oxidative and osmotic stress responses and virulence in uropathogenic Escherichia coli. ⁶²	Bessaiah H...Dozois CM	34043736	2021
40	Fluorescence polarization assay improves the rapid detection of human brucellosis in China. ⁶²	Dong SB...Jiang H	33789762	2021
41	Seroprevalence of Bovine Brucellosis in Ethiopia: Systematic Review and Meta-Analysis. ⁶²	Tesfaye A...Bitew AB	33469511	2021
42	Structural and Molecular Dynamics of Mycobacterium tuberculosis Malic Enzyme, a Potential Anti-TB Drug Target. ⁶²	Burley KH...Goulding CW	33356117	2021
43	Increased Level of Interleukin-8 in Female Genital Tract After HP Eradication Lines. ⁶²	Kravtsov V...Kalinina N	33397248	2021
44	Discovery of Potent Inhibitors of Streptococcus mutans Biofilm with Antivirulence Activity. ⁶²	Nijampatnam B...Velu SE	33488963	2021
45	Evodiae fructus Extract Inhibits Interleukin-1β-Induced MMP-1, MMP-3, and Inflammatory Cytokine Expression by Suppressing the Activation of MAPK and STAT-3 in Human Gingival Fibroblasts In Vitro. ⁶²	Song HK...Lee YR	34504537	2021
46	Editorial: Tissue Remodeling in Health and Disease Caused by Bacteria, Parasites, Fungi, and Viruses. ⁶²	Lange S...Ramirez MI	33604310	2021
47	Campylobacteriosis in Poland in 2018-2019. ⁶²	Gordat K...Sadkowska-Todys M	35543598	2021
48	Seroprevalence and risk factors of brucellosis and the brucellosis model at the individual level of dairy cattle in the West Bandung District, Indonesia. ⁶²	Yanti Y...Sodirun S	33642780	2021
49	Case Report: Metagenomic Next-Generation Sequencing Confirmed a Case of Central Nervous System Infection With Brucella melitensis in Non-endemic Areas. ⁶²	Cao J...Xia Z	34595192	2021
50	[What does a general practitioner need to know about whooping cough?] ⁶²	Rochat M...Favrat B	33300701	2020

Sources

Genes for Bacterial Infectious Disease

Genes related to Bacterial Infectious Disease (0 elite genes):

(show top 50) (show all 88)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	CRP	C-Reactive Protein	Protein Coding	18.66	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18534215 10530060 12149826 (more) 8038314 15690970 20351152 2011307 15990980 19675669 17573524 19351421 16188765 8511515 7865632 7667605 12478975 9024449 18470711 9755278 15909479 14551491 2050427 15307030 12940634 10530583 10462333 7525084 19365169 17989854 19664100 19158133 11055657 2275041 19086461 12350029 18946456 17727748 10686961 16490683 15046268 7724300 12422291 7506645 19480860 1764778 9544899 9722037 11215485 11391955 9642511 9350334 9058297 8539715 8067666 8017182 2024262 1539125 8419041 1720888 19949364 19541708 20192933 19594772 18442829 16481557 15563869 7506886 19768224 18341874 17982719 17163818 15353049 15324368 10708183 9506644 8108178 1295765 2354815 20379412 19728551 17148079 11578539 10469768 15353050 15276911 15046277 14720497 14531129 12975117 12553440 11957124 2265018 2332012 19238436 19291300 19205372 18581011 18097067 17178038
2	TNF	Tumor Necrosis Factor	Protein Coding	17.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17393394 12817618 8207959 (more) 19436694 7553424 1954355 11080076 16785730 12975117 17530704 9386355 2279003 1314439 8795811 9352536 10885842 10385017 11503575 15077592 9115613 9575350 7539547 7927669 8345430 8500890 2274926 19205372 17699977 10758241 10664236 10469238 9564633 9424334 9218605 8067666 8142598 1375198 20171921 15283848 10667525 9917883 9343439 9112576 9029512 2162324 16177321 8515117 2305745 19395784 19224750 18466796 17400579 16311059 16025514 15365859 9839076 7930484 14523047 12960779 12517998 8994098 8681977 7865347 1940975 1940351 8154970 7687236 2391423 20233427 8089217 18240280 16785508 14748511 19760065 18162526 18179556 16239381 10790736 9350884 8648113 7772638 1579588 18050253 17127203 11720745 1660140 2104745 17600314 14993593 14987733 12853386 11219189 11043572 12801966 10731475 10321674 9917896 9175802 8458719
3	TLR4	Toll Like Receptor 4	Protein Coding	17.35	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12853386 16738534 11260138 (more) 11781369 16395111 18424732 16567359 17709532 9394624 15882292 12190866 19528814 19525014 15656985 15640363 17100621 16338476 10843389 16785240 19067670 17093906 19960069 17284926 15608698 16487238 16219455 12324481 17437421
4	IL6	Interleukin 6	Protein Coding	17.07	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8547081 8548665 10731475 (more) 11271398 8265324 1321519 16492989 15990980 1443833 10686961 7528531 18321393 18946456 16785730 12975117 8319784 7898909 9685429 10774960 15077592 2143517 8067666 1398949 18470711 14987733 12693563 7522641 7917851 8500890 1580206 18780664 18343764 16237103 12824003 10667525 9917883 19436694 18179556 17065508 20526368 18972261 17577814 17355946 16148175 14649675 11607849 11082952 9839076 9481022 7930484 1833314 2124237 8681977 7865347 8498648 1558416 12456936 11345222 9506644 7591361 19626562 15662595 9350884 7632033 7772638 8026198 14685560 11125929 10664236 10530583 10427870 9058297 17362770 15509024 11503575 9917896 10885842 10321674 10385017
5	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	16.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12853386 10462333 11005618 (more) 11271398 1314439 10469768 15123821 16492989 10639436 15174789 8319784 9352536 15077592 15494523 19428485 17374489 16794530 11509811 18380907 11485758 10947149 9322504 10664236 10213254 9041336 17220369 17196571 17177974 16234511 15319462 7865347 8418474 18771559 18321393 17577814 16939955 15300205 11607849 11082952 10754314 8943872 11683191 10667525 9917883 9386355 8276881 7554553 19436694 18678662 15740640 14987733 8073511 7917851 7522641 7927669 11877427
6	TLR2	Toll Like Receptor 2	Protein Coding	16.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	12853386 17437421 17889686 (more) 20402597 16487238 16115866 17284926 16754688 17100621 18202345 11035751 15656985 17093906 17554618 19167648
7	IL1B	Interleukin 1 Beta	Protein Coding	15.81	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14685560 9386355 10885842 (more) 10786965 11503575 8500890 7927669 19656972 10667525 17355946 9839076 2305745 14523047 8681977 7553957 8698137 11080076 12853386 7606878 10469238 10664236 11849384
8	IFNG	Interferon Gamma	Protein Coding	15.54	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	8457320 20027351 18347031 (more) 1714327 8319784 9822292 10885842 11014893 11207649 11503575 16785508 9386355 9343439 8805617 7977435 2163132 16943387 16352694 11006153 9099678 15192329 12960010 12802027 18608175 15494539 1940975 15283848 10790736 15550127 11261329 12939340 8450264 10758241 11849384
9	CSF3	Colony Stimulating Factor 3	Protein Coding	14.88	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7528531 7511941 7528729 (more) 7536638 7553424 15762880 1719175 17127321 7693041 7512258 7692930 17580308 1709377 9528719 1691248 1279243 1722258 2317799 16551969 17631177 9738693 9180283 8971093 8273986 17577814 16229088 15198743 12027409 10671324 9198845 8648534 11399510 9834829 8840537 7691262 8544376 7684099 7554553 16398742 7520659 7681657 15238147 9373205 7679362 1698897 17205286 10878148 11190272
10	DEFB4A	Defensin Beta 4A	Protein Coding	14.76	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	20476598 12760504 10512755 (more) 10586069 12522054 12819054 15547668 14981906 11207625 12470478 12238953 12847264 19732743 11781391
11	CAMP	Cathelicidin Antimicrobial Peptide	Protein Coding	14.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19605696 12454100 12819054 (more) 16751768 16100459 18275123 14963039 19770273 14620153
12	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	14.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15905496 15069404 17878374 (more) 19430930 16647422 18986247 19689377 18174872 15825022 12925671 17026873
13	IL10	Interleukin 10	Protein Coding	14.42	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9697751 14987733 17878348 (more) 15350162 12414752 16148175 10481411 7646518 19084429 9178365
14	DEFB1	Defensin Beta 1	Protein Coding	13.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	20476598 12238953 12819054
15	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	13.42	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18986247
16	NOD1	Nucleotide Binding Oligomerization Domain Containing 1	Protein Coding	13.33	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17690884 16172124
17	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	13.25	DISEASES inferred ¹⁴ ¹⁴
18	ELANE	Elastase, Neutrophil Expressed	Protein Coding	13.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7927669 10595584 2127877 (more) 9122714 14962902 8850170 15661916 1495862
19	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	13.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17690884 16952484 16714539 (more) 17057187
20	IL17A	Interleukin 17A	Protein Coding	13.1	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19283706 18200634
21	BTK	Bruton Tyrosine Kinase	Protein Coding	13.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11206059 11668622 15142874 (more) 16053733 19067895 12204007 10826882
22	IL18	Interleukin 18	Protein Coding	12.91	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11964842 10886219 12898884 (more) 11894141 12781884 14523047 15464021
23	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	12.74	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19596984 19149696 19479878 (more) 12792857
24	DEFB103B	Defensin Beta 103B	Protein Coding	12.74	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	19372483 12819054 15729370
25	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	12.52	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15246977 19639288 10751364 (more) 11286194 19931506 8612275 11845302 14613541 11872746 9851885 11717455 17222164 20375556 11307750
26	TLR3	Toll Like Receptor 3	Protein Coding	12.44	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	18083507
27	MBL2	Mannose Binding Lectin 2	Protein Coding	12.37	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17552055 17143875 18611155 (more) 9863582 9871992 15674393 17729243 19758139 17275645 9298100 14614673 17484222 18292811 7776856 12930361
28	LBP	Lipopolysaccharide Binding Protein	Protein Coding	12.31	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	9360683 16407966 17259880 (more) 17328727 15145636 15499153 16123407 19541708 11739189 9565687
29	TLR9	Toll Like Receptor 9	Protein Coding	12.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17030073 16164440
30	CSF2	Colony Stimulating Factor 2	Protein Coding	12.27	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7898909 7506824 14987733 (more) 8805617 7528729 11399510
31	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	12.22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15670593 17997719
32	ITGAM	Integrin Subunit Alpha M	Protein Coding	12.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15475363 11861933
33	FCGR1A	Fc Gamma Receptor Ia	Protein Coding	12.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17577814 16028647 16308225 (more) 12558136 9010254 10367781 16083552
34	CASP1	Caspase 1	Protein Coding	12.09	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17932464 18329614 20067841 (more) 19539499 17126540 16824040 17696608 20201017
35	TLR5	Toll Like Receptor 5	Protein Coding	11.84	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15339910
36	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	11.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	11429160
37	TLR1	Toll Like Receptor 1	Protein Coding	11.75	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	20153434
38	SELL	Selectin L	Protein Coding	11.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7534904
39	FPR1	Formyl Peptide Receptor 1	Protein Coding	11.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15187149 15623572 11238229 (more) 18060741 18253729
40	FCGR2A	Fc Gamma Receptor IIa	Protein Coding	11.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14740869
41	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	11.22	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1937535 17097662 12702515
42	LTF	Lactotransferrin	Protein Coding	11.14	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1506633 1780084 20148305 (more) 1702815 15950395 1495862 10639436 18321995 20364433 10739520 7762425 11937551 16375677 12704108 11509640
43	FCGR3B	Fc Gamma Receptor IIIb	Protein Coding	11.09	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	2136822
44	CD14	CD14 Molecule	Protein Coding	11.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10774960 18424732 17284926 (more) 17900622 18991094 11985523 12190866 12414752 12558136
45	PGLYRP1	Peptidoglycan Recognition Protein 1	Protein Coding	11.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	14698226
46	BPI	Bactericidal Permeability Increasing Protein	Protein Coding	11.01	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17145792 12869032 15009116 (more) 20027298
47	CFP	Complement Factor Properdin	Protein Coding	10.95	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7501623 8809142 2397612
48	IL3	Interleukin 3	Protein Coding	10.89	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7553424 7898909 10189687 (more) 15458513
49	LCN2	Lipocalin 2	Protein Coding	10.89	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	7667605 16188765 16308225 (more) 12693563 11058770 15531878
50	PTX3	Pentraxin 3	Protein Coding	10.85	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15977234 17277044 11404378

Sources

Variations for Bacterial Infectious Disease

Sources

Expression for Bacterial Infectious Disease

Search GEO for disease gene expression data for Bacterial Infectious Disease.

Sources

Pathways for Bacterial Infectious Disease

Pathways directly related to Bacterial Infectious Disease:

#	Pathway	Source
1	Microbial modulation of RIPK1-mediated regulated necrosis	Reactome ⁶⁶

Pathways related to Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 77)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.87	TNF IRAK4 IL6 IL1B IL17A IL10
2	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.87	IL10 IL17A IL1B IL6 IRAK4 MYD88
3	MIF Mediated Glucocorticoid Regulation ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ Overview of proinflammatory and profibrotic mediators ⁷⁴ PEDF Induced Signaling ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.72	TNF TLR4 IL6 IL1B IL17A IL10
4	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.71	CAMP CCR6 CRP CSF3 CXCL8 DEFB1
5	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.53	TNF TLR4 TLR2 MYD88 IRAK4 IL6
6	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.5	TNF TLR4 TLR2 MYD88 IRAK4 IL6
7	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.39	CCR6 CSF3 CXCL8 IL10 IL17A IL1B
8	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.38	CSF3 CXCL8 IFNG IL10 IL17A IL1B
9	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.99	TNF TLR4 TLR2 MYD88 IRAK4 IL6
10	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.85	TNF TLR4 TLR2 MYD88 IRAK4 IL6
11	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways IL1 signaling pathway ⁶⁷ Immune response IL-1 signaling pathway ²² Interleukin-1 (IL-1) structural pathway ⁷⁴ Interleukin-33 signaling ⁶⁶ Interleukin-36 pathway ⁶⁶ Mucin expression in CF via TLRs, EGFR signaling pathways ²² Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.77	CXCL8 IL1B IL6 IRAK4 MYD88 TLR2
12	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.75	TNF IL6 IL1B IL17A IL10 IFNG
13	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions ⁶⁵ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ TNFs bind their physiological receptors ⁶⁶ TRAF Pathway ⁶⁴	12.74	TNF TLR4 TLR2 MYD88 IRAK4 IL1B
14	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.71	TNF IL6 IL1B IL17A IL10 IFNG
15	NF-kappaB Signaling ³	12.66	TNF TLR2 NOD1 MYD88 IRAK4 IL1B
16	Interleukin-1 family signaling ⁶⁶ Show member pathways Interleukin-1 signaling ⁶⁶ Interleukin-18 signaling ⁶⁶ Interleukin-38 signaling ⁶⁶	12.57	NOD2 NOD1 MYD88 IRAK4 IL1B
17	Defensins ⁶⁶ Show member pathways Alpha-defensins ⁶⁶ Antimicrobial peptides ⁶⁶ Beta defensins ⁶⁶ Ion influx/efflux at host-pathogen interface ⁶⁶ Metal sequestration by antimicrobial proteins ⁶⁶	12.46	TLR2 ELANE DEFB4A DEFB1 CCR6 CAMP
18	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.45	TNF TLR4 TLR2 NOD2 NOD1 MYD88
19	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ⁶⁷ IL-17 signaling pathway ⁷⁴ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.44	TNF TLR2 IL6 IL17A CXCL8 CSF3
20	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.44	TNF TLR4 MYD88 IRAK4 IL6 IL1B
21	Bacterial infections in CF airways ²² Show member pathways Altered glycosylation of MUC1 in tumor microenvironment ⁷⁴ IL-1 beta-dependent CFTR expression ²² IL1-mediated signaling events ⁶¹ Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²² NTHi-Induced Signaling ⁶⁴ Signal transduction through IL1R ⁷⁴	12.42	CXCL8 DEFB4A IFNG IL1B IL6 IRAK4
22	Colorectal Cancer Metastasis ⁶⁴	12.32	TNF TLR4 TLR2 IL6 IFNG
23	Diseases of Immune System ⁶⁶ Show member pathways Diseases associated with the TLR signaling cascade ⁶⁶ Endogenous TLR signaling ⁶¹ IRAK4 deficiency (TLR2/4) ⁶⁶ IRAK4 deficiency (TLR5) ⁶⁶ MyD88 deficiency (TLR2/4) ⁶⁶ MyD88 deficiency (TLR5) ⁶⁶ Regulation of TLR by endogenous ligand ⁶⁶ Toll-like receptor signaling related to MyD88 ⁷⁴ Transfer of LPS from LBP carrier to CD14 ⁶⁶	12.3	TLR4 TLR2 MYD88 IRAK4
24	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.3	TNF IL6 IL1B IL10 CXCL8
25	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.28	TNF MYD88 IL17A IL10 IFNG
26	Neuroinflammation and glutamatergic signaling ⁷⁴	12.24	TNF IL6 IL1B IL10 IFNG
27	Spinal cord injury ⁷⁴	12.17	TNF TLR4 IL6 IL1B IFNG CXCL8
28	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	12.15	CSF3 IFNG IL10 IL6 TNF
29	Interleukin-4 and Interleukin-13 signaling ⁶⁶	12.13	TNF IL6 IL1B IL17A IL10 CXCL8
30	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	12.06	TLR4 MYD88 IL6 IL17A CXCL8 CSF3
31	Allograft rejection ⁷⁴	12.06	TNF IL1B IL17A IL10 IFNG CXCL8
32	Senescence and autophagy in cancer ⁷⁴	12.05	IL6 IL1B IFNG CXCL8
33	Th17 Differentiation ⁶⁵ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	12.03	IFNG IL17A IL1B IL6 TLR2 TLR4
34	CCL18 signaling pathway ⁷⁴	12.01	IL6 IL10 CXCL8 CCR6
35	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.97	TNF TLR4 TLR2 IL6 IL1B IL17A
36	Innate Lymphoid Cells Differentiation ⁶⁵	11.96	TNF IL1B IL17A IL10 IFNG CCR6
37	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.93	TNF IL6 IL1B IL10 IFNG
38	Burn wound healing ⁷⁴	11.91	TNF TLR4 MYD88 IL6 IL1B CXCL8
39	Acute viral myocarditis ⁷⁴	11.89	TLR4 IL6 IL10 IFNG
40	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.88	TNF TLR4 IL6 IL10 IFNG CRP
41	AP-1 transcription factor network ⁶¹	11.85	CXCL8 IFNG IL10 IL6
42	Th17 cell differentiation pathway ⁷⁴	11.85	IFNG IL17A IL1B IL6
43	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.84	TNF IL6 IL1B IFNG CXCL8
44	Lung fibrosis ⁷⁴	11.84	TNF IL6 IL1B CXCL8 CSF3
45	Activation of NF-KappaB by PKR ⁶⁴ Show member pathways Canonical NF-kB pathway ⁷⁴ Cellular Transformation by HTLV1 ⁶⁴ Inhibition of PKR ⁶⁶ STING pathway in Kawasaki-like disease and COVID-19 ⁷⁴	11.83	TNF IL1B IFNG
46	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.81	IL6 CXCL8 CRP
47	Glucocorticoid receptor regulatory network ⁶¹	11.81	IL6 IFNG CXCL8
48	IL 10 signaling pathway ⁶⁷	11.77	TNF TLR4 MYD88 IRAK4 IL6 IL1B
49	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.75	TNF IFNG CXCL8
50	NF-kB (NFkB) Pathway ⁶⁷	11.74	IRAK4 MYD88 TLR4 TNF

Sources

GO Terms for Bacterial Infectious Disease

Cellular components related to Bacterial Infectious Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	10.07	TNF IL6 IL1B IL17A IL10 IFNG
2	extracellular space	GO:0005615	9.77	CAMP CRP CSF3 CXCL8 DEFB1 DEFB4A

Biological processes related to Bacterial Infectious Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 86)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.7	CSF3 IL10 IL17A IL1B IL6 NOD2
2	signal transduction	GO:0007165	10.64	CCR6 CSF3 CXCL8 IFNG IL10 IL1B
3	positive regulation of gene expression	GO:0010628	10.58	CRP CXCL8 IFNG IL1B IL6 MYD88
4	innate immune response	GO:0045087	10.58	CAMP CRP DEFB1 IL17A IRAK4 MYD88
5	apoptotic process	GO:0006915	10.57	IFNG IL17A IL1B MYD88 NOD1 TLR2
6	inflammatory response	GO:0006954	10.51	CRP CXCL8 IL17A IL1B IL6 MYD88
7	negative regulation of cell population proliferation	GO:0008285	10.5	TNF TLR2 IL6 IL1B IL10 CXCL8
8	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	10.46	TNF TLR4 NOD2 NOD1 MYD88 IRAK4
9	positive regulation of NF-kappaB transcription factor activity	GO:0051092	10.4	TNF TLR4 TLR2 NOD2 NOD1 MYD88
10	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.39	CSF3 IL10 IL1B IL6 TNF
11	positive regulation of JNK cascade	GO:0046330	10.38	TNF TLR4 NOD2 NOD1 MYD88 IL1B
12	defense response to bacterium	GO:0042742	10.38	CAMP DEFB1 DEFB4A ELANE IL10 MYD88
13	defense response to Gram-negative bacterium	GO:0050829	10.37	TLR4 IL6 IL17A DEFB4A DEFB1 CAMP
14	cytokine-mediated signaling pathway	GO:0019221	10.36	MYD88 IRAK4 IL6 IL1B CSF3
15	positive regulation of inflammatory response	GO:0050729	10.36	IFNG IL1B TLR2 TLR4 TNF
16	positive regulation of tumor necrosis factor production	GO:0032760	10.36	TLR4 TLR2 NOD2 NOD1 MYD88 IL6
17	positive regulation of MAP kinase activity	GO:0043406	10.35	ELANE IL1B NOD2 TLR4 TNF
18	positive regulation of NIK/NF-kappaB signaling	GO:1901224	10.35	TNF TLR4 TLR2 NOD2 NOD1 IL1B
19	positive regulation of smooth muscle cell proliferation	GO:0048661	10.33	ELANE IL6 IRAK4 MYD88 TLR4 TNF
20	phagocytosis	GO:0006909	10.32	ELANE MYD88 NOD2 TLR4
21	antimicrobial humoral immune response mediated by antimicrobial peptide	GO:0061844	10.32	DEFB4A DEFB1 CXCL8 CAMP
22	JNK cascade	GO:0007254	10.32	IL1B IRAK4 MYD88 NOD1 NOD2 TLR4
23	humoral immune response	GO:0006959	10.31	TNF IL6 IFNG CCR6
24	positive regulation of interleukin-12 production	GO:0032735	10.31	IFNG IL17A NOD2 TLR2 TLR4
25	I-kappaB kinase/NF-kappaB signaling	GO:0007249	10.31	IL1B MYD88 NOD1 NOD2 TLR4 TNF
26	lipopolysaccharide-mediated signaling pathway	GO:0031663	10.3	IL1B MYD88 TLR2 TLR4 TNF
27	cellular response to lipopolysaccharide	GO:0071222	10.3	CAMP CSF3 CXCL8 IL10 IL1B IL6
28	positive regulation of phagocytosis	GO:0050766	10.29	TNF NOD2 IL1B IFNG
29	regulation of insulin secretion	GO:0050796	10.29	TNF IL6 IL1B IFNG
30	immune response	GO:0006955	10.28	TNF TLR4 TLR2 IL6 IL1B IL17A
31	positive regulation of nitric oxide biosynthetic process	GO:0045429	10.27	TNF TLR4 IL1B IFNG
32	positive regulation of interleukin-10 production	GO:0032733	10.27	TLR4 TLR2 NOD2 IL6
33	positive regulation of cytokine production involved in inflammatory response	GO:1900017	10.27	TNF TLR4 NOD2 MYD88 IL6 IL17A
34	positive regulation of interleukin-1 beta production	GO:0032731	10.27	TNF TLR4 NOD2 NOD1 MYD88 IL6
35	positive regulation of cytokine production	GO:0001819	10.26	TNF IL1B IL10 IFNG
36	immune system process	GO:0002376	10.25	IL17A IRAK4 MYD88 NOD1 NOD2 TLR2
37	positive regulation of macrophage cytokine production	GO:0060907	10.25	TLR4 NOD2 NOD1 MYD88
38	response to lipopolysaccharide	GO:0032496	10.25	ELANE IL10 IL1B MYD88 NOD2 TLR2
39	positive regulation of chemokine production	GO:0032722	10.25	IFNG IL1B IL6 MYD88 TLR2 TLR4
40	negative regulation of type II interferon production	GO:0032689	10.24	TLR4 NOD2 IL10
41	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	10.24	TLR4 TLR2 MYD88 IRAK4
42	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.23	TNF IL6 IL10
43	regulation of inflammatory response	GO:0050727	10.23	TNF TLR4 NOD2 MYD88
44	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	10.23	IFNG NOD2 TLR2 TLR4
45	liver regeneration	GO:0097421	10.22	TNF IL6 IL10
46	innate immune response in mucosa	GO:0002227	10.22	NOD2 DEFB1 CAMP
47	microglial cell activation	GO:0001774	10.22	TNF TLR2 IFNG
48	positive regulation of interleukin-17 production	GO:0032740	10.22	IL6 MYD88 NOD2
49	negative regulation of neurogenesis	GO:0050768	10.22	IL1B IL6 TNF
50	toll-like receptor signaling pathway	GO:0002224	10.21	TLR4 TLR2 IRAK4

Molecular functions related to Bacterial Infectious Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	lipopolysaccharide binding	GO:0001530	9.8	TLR4 TLR2 CAMP
2	pattern recognition receptor activity	GO:0038187	9.73	NOD1 NOD2 TLR2
3	lipopolysaccharide immune receptor activity	GO:0001875	9.67	TLR4 TLR2
4	peptidoglycan binding	GO:0042834	9.63	NOD1 NOD2 TLR2
5	cytokine activity	GO:0005125	9.5	TNF IL6 IL1B IL17A IL10 IFNG
6	interleukin-1 receptor binding	GO:0005149	9.43	MYD88 IRAK4 IL1B