MCID: BCT007
MIFTS: 55

Bacterial Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Bacterial Meningitis

MalaCards integrated aliases for Bacterial Meningitis:

Name: Bacterial Meningitis 12 74 52 3 15 17
Meningitis, Bacterial 52 43 71
Meningitis Bacterial 54

Classifications:



External Ids:

Disease Ontology 12 DOID:9470
ICD9CM 34 320 320.9
MeSH 43 D016920
NCIt 49 C118297
SNOMED-CT 67 95883001
ICD10 32 G00 G00.9
UMLS 71 C0085437

Summaries for Bacterial Meningitis

CDC : 3 Bacterial meningitis is very serious and can be deadly. Death can occur in as little as a few hours. Most people recover from meningitis. However, permanent disabilities (such as brain damage, hearing loss, and learning disabilities) can result from the infection. Several types of bacteria can cause meningitis. Leading causes in the United States include Streptococcus pneumoniae Group B Streptococcus Neisseria meningitidis Haemophilus influenzae Listeria monocytogenes These bacteria can also be associated with another serious illness, sepsis. Sepsis is the body’s extreme response to infection. Without timely treatment, sepsis can quickly lead to tissue damage, organ failure, and death.

MalaCards based summary : Bacterial Meningitis, also known as meningitis, bacterial, is related to aseptic meningitis and viral meningitis. An important gene associated with Bacterial Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Phenytoin and Cefotaxime have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A meningitis that has material basis in a bacterial infection.

Wikipedia : 74 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Bacterial Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 907)
# Related Disease Score Top Affiliating Genes
1 aseptic meningitis 33.2 TNF IL1B IL10 CXCL8
2 viral meningitis 33.0 IL6 CXCL8 CRP
3 haemophilus influenzae 32.6 TNF TLR2 CXCL8
4 pneumococcal meningitis 32.6 MMP9 C3
5 meningococcal meningitis 32.6 TLR9 TLR4 TLR2 CFP C3
6 cerebral palsy 32.1 TNF TLR4 S100B MMP8 IL6 IL1B
7 tuberculous meningitis 31.6 TNF TLR2 MMP9 CXCL8
8 hydrocephalus 31.3 TNF TLR4 TLR2 S100B IL10 AQP4
9 intracranial hypertension 31.1 TNF IL1B AQP4 ALB
10 neisseria meningitidis infection 31.0 TLR4 TLR2 CFP C3
11 meningoencephalitis 30.7 TNF IL6 IL10 CRP ALB
12 septic arthritis 30.7 TLR9 TLR4 TLR2 CXCL8 CRP
13 fungal meningitis 30.7 TNF IL6 IL10
14 brain injury 30.7 S100B IL6 IL10 AQP4
15 epidemic typhus 30.7 TLR4 TLR2 CRP
16 vasculitis 30.6 TNF IL6 CRP C3
17 infective endocarditis 30.6 TNF TLR2 IL6 CRP
18 encephalitis 30.6 TNF IL6 IL1B IL10 CCL4 AQP4
19 herpes zoster 30.6 TNF TLR2 IL10 CRP
20 suppurative otitis media 30.6 TLR4 TLR2 IL1B CRP
21 toxic shock syndrome 30.5 TNF TLR4 TLR2 IL6 IL1B IL10
22 listeriosis 30.5 TNF TLR4 TLR2 IL6 IL10
23 viral encephalitis 30.4 TNF IL6 IL1B IL10 CXCL8
24 rubella 30.4 TNF TLR4 IL6 IL10
25 brain edema 30.4 MMP9 IL6 IL1B CRP AQP4 ALB
26 streptococcus pneumonia 30.4 TNF TLR9 TLR4 TLR2 IL6 IL10
27 scrub typhus 30.4 TNF TLR4 TLR2 IL1B IL10 CRP
28 measles 30.4 TNF TLR9 TLR4 TLR2 IL6 IL1B
29 thrombocytosis 30.4 IL6 IL1B CRP ALB
30 myelitis 30.4 TNF MMP9 IL6 IL10 CXCL8 AQP4
31 encephalomalacia 30.3 TLR4 S100B IL6 IL1B CRP
32 traumatic brain injury 30.3 S100B MMP9 IL6 IL10 AQP4
33 varicose veins 30.3 TNF MMP9 IL6 CXCL8
34 iridocyclitis 30.3 TNF IL6 CRP
35 disseminated intravascular coagulation 30.2 TNF PIK3C2A IL6 IL10 CRP
36 erythema multiforme 30.2 TNF IL6 CXCL8
37 pharyngitis 30.2 TNF IL6 IL1B CXCL8 CRP
38 cerebrovascular disease 30.2 TNF TLR4 MMP9 IL6 CRP
39 meningitis 30.2 TNF TLR9 TLR4 TLR2 S100B MMP9
40 osteomyelitis 30.2 TNF TLR4 TLR2 IL6 IL1B IL10
41 acute disseminated encephalomyelitis 30.1 IL1B IL10 CCL4 AQP4
42 intussusception 30.1 IL6 CRP ALB
43 protein-energy malnutrition 30.1 TNF IL6 ALB
44 exanthem 30.1 TNF PIK3C2A IL6 IL10 CXCL8 CRP
45 cellulitis 30.1 TNF IL6 IL10 CRP
46 spondylitis 30.1 TNF IL6 IL10 CRP
47 chickenpox 30.1 TNF TLR9 IL6 IL10 CRP ALB
48 mumps 30.1 TNF IL6 IL10 CXCL8
49 herpes simplex 30.1 TNF TLR9 TLR2 C3
50 purpura 30.1 TNF IL6 IL10 CRP C3

Comorbidity relations with Bacterial Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to Bacterial Meningitis

Symptoms & Phenotypes for Bacterial Meningitis

MGI Mouse Phenotypes related to Bacterial Meningitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 ALB AQP4 C3 CFP CRP IL10
2 homeostasis/metabolism MP:0005376 10.22 ALB AQP4 C3 CFP CRP IL10
3 immune system MP:0005387 10.13 ALB AQP4 C3 CFP CRP IL10
4 hematopoietic system MP:0005397 10.11 AQP4 C3 IL10 IL1B IL6 MMP9
5 digestive/alimentary MP:0005381 10.1 ALB AQP4 C3 IL10 IL6 MMP9
6 muscle MP:0005369 9.76 ALB C3 IL10 IL6 MMP9 TLR2
7 neoplasm MP:0002006 9.61 ALB IL10 IL1B IL6 MMP8 MMP9
8 renal/urinary system MP:0005367 9.28 ALB AQP4 C3 IL6 MMP9 PIK3C2A

Drugs & Therapeutics for Bacterial Meningitis

Drugs for Bacterial Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 138)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Cefoxitin Approved Phase 4 35607-66-0 441199
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
8
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
9 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
12
Azathioprine Approved Phase 4 446-86-6 2265
13
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
14 Anticonvulsants Phase 4
15 Diuretics, Potassium Sparing Phase 4
16 Sodium Channel Blockers Phase 4
17 Vaccines Phase 4
18 Immunologic Factors Phase 4
19 Analgesics, Non-Narcotic Phase 4
20 Antipyretics Phase 4
21 beta-Lactams Phase 4
22 Lactams Phase 4
23 Analgesics Phase 4
24 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
25 Gentamicins Phase 4
26 penicillins Phase 4
27 Protective Agents Phase 4
28 Anti-Inflammatory Agents Phase 4
29 Antiemetics Phase 4
30 Methylprednisolone Acetate Phase 4
31 Hormone Antagonists Phase 4
32 Neuroprotective Agents Phase 4
33 Autonomic Agents Phase 4
34 Hormones Phase 4
35 glucocorticoids Phase 4
36 Immunoglobulins Phase 4
37 Antibodies Phase 4
38 HIV Protease Inhibitors Phase 4
39
protease inhibitors Phase 4
40 BB 1101 Phase 4
41 Antineoplastic Agents, Hormonal Phase 4
42 Antimetabolites Phase 4
43 Antirheumatic Agents Phase 4
44 Immunosuppressive Agents Phase 4
45 Neuromuscular Blocking Agents Phase 4
46
Glycerol Approved, Investigational Phase 3 56-81-5 753
47 Pharmaceutical Solutions Phase 2, Phase 3
48 Immunoglobulins, Intravenous Phase 3
49 Rho(D) Immune Globulin Phase 3
50 gamma-Globulins Phase 3

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. A Multi-center Comparative Randomized Double-blind and Placebo-controlled Clinical Trial Unknown status NCT01478035 Phase 4 Phenytoin;placebo
2 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola. Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
3 An Open Randomised Trial of Ceftriaxone v Penicillin and Gentamicin in Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
4 Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children Who Attend the Emergency Department Completed NCT03698630 Phase 4 Prednisolone Sodium Phosphate;Dexamethasone
5 Evaluation of the Effect of Tetravalent (A, C, Y, W-135) Meningococcal Conjugate Vaccine on Serogroup-Specific Carriage of Neisseria Meningitidis Completed NCT00119080 Phase 4
6 Pneumococcal Vaccination of Crohn Patients - A Randomized, Non-blinded Phase 4 Clinical Trial With the Purpose of Investigating the Immune Response Against Two Different Pneumococcal Vaccines in Patients With Crohn's Disease Completed NCT01947010 Phase 4
7 Comparison of the Immunogenicity of the 3+1 Schedule and the 2+1 Schedule of 7-valent Pneumococcal Conjugated Vaccine in Young Chinese Infants Completed NCT02040402 Phase 4
8 Mild Induced Hypothermia to Treat Severe Community Acquired Meningitis in Adults Admitted to Intensive Care Unit Terminated NCT00774631 Phase 4
9 Amikacin Penetration Into the Cerebrospinal Fluid: Pharmacokinetic/Pharmacodynamic Analysis in Adults With Hospital Acquired Gram-negative Meningitis Associated With Intracranial Pressure Monitoring and Draining Devices Withdrawn NCT00362245 Phase 4 Systemic and Intra-Thecal Amikacin Therapy
10 A Phase 3, Multicenter, Open-label Study to Evaluate Immunogenicity and Safety of Novartis Meningococcal ACWY Conjugate Vaccine (MenACWY-CRM) in Healthy Subjects From 2 to 18 Years in Taiwan Completed NCT01410474 Phase 3
11 A Phase 3, Multi-center, Open-label Study to Evaluate Immunogenicity and Safety of Novartis Meningococcal ACWY Conjugate Vaccine (MenACWY-CRM) in Healthy Subjects From 2 to 75 Years of Age in India. Completed NCT01547715 Phase 3
12 Open-label, Randomized, 3-arm, Phase 3B Clinical Study to Investigate the Safety and Immunogenicity of a Concomitant Administration of Group C Meningococcal Polysaccharide-Tetanus Toxoid Conjugate (MenC-TT) Vaccine and 7-valent Pneumococcal CRM197-conjugate Vaccine (PCV7) in Toddlers Previously Immunized During Infancy With PCV7 Completed NCT00617760 Phase 3
13 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis - A Prospective, Randomized, and Double-Blind Clinical Study Using a Two-by-Two Factorial Design Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
14 Immunogenicity and Safety of the DTaP-IPV/Hib Vaccine SP0204) Given as Three-dose Primary and One-dose Booster Vaccinations Versus Co-administration of DTaP-IPV Vaccine (DD-687) and Hib Vaccine (DF-098) in Infants in Japan Completed NCT02274285 Phase 3
15 Safety and Immunogenicity Study for Use of Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine (Menactra®) in Healthy Subjects 2-55 Years of Age in India Completed NCT01086969 Phase 3
16 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
17 Immunogenicity and Safety of Bivalent Meningococcal Serogroups A and C Tetanus Toxoid Conjugate Vaccine in Chinese Healthy Children Aged 3 Months to 5 Years.: A Randomized, Blinded, Positive Controlled Phase III Clinical Trial Completed NCT03714737 Phase 3
18 A Phase III, Multicenter, Open-Label Study To Evaluate The Efficacy, Safety, and Pharmacokinetics of Gammaplex® in Primary Immunodeficiency Diseases Completed NCT00278954 Phase 3
19 A Randomized Observer-blinded Controlled Non-inferiority Trial to Evaluate the Immunogenicity of Locally Manufactured Meningococcal ACWY Vaccine 'Ingovax ACWY' in Bangladeshi Healthy Adults. Completed NCT03263403 Phase 2, Phase 3
20 Phase 3 Study of BK1310 Compared With ActHIB® and Tetrabik in Healthy Infants: A Randomized, Assessor-blind, Active-controlled Active, not recruiting NCT03891758 Phase 3
21 A Phase II Randomized Trial of Amphotericin B Alone or Combined With Fluconazole in the Treatment of AIDS-Associated Cryptococcal Meningitis Completed NCT00145249 Phase 2 Amphotericin B;Fluconazole
22 Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days of Age (Inclusive) With Probable and Confirmed Meningitis: A European Multicenter Phase I-II Trial Completed NCT01554124 Phase 1, Phase 2 Meropenem
23 Phase I/II Study of Safety and Immunogenicity of Quadrivalent Meningococcal Conjugate Vaccine (MCV4) in HIV-Infected Children and Youth And Open Label Immunogenicity Study of a Booster Dose of MCV4 in Previously Immunized HIV-Infected Children and Youth Completed NCT00459316 Phase 1, Phase 2
24 MULTICENTRIC, PHASE II, CLINICAL TRIAL CORTICOIDS FOR EMPYEMA AND PLEURAL EFFUSION IN CHILDREN Completed NCT01261546 Phase 2 Dexamethasone;Placebo
25 A Phase II, Open Label, Randomised, Single Centre Study To Evaluate The Importance Of Naturally Induced Immune Regulation On The Mucosal Immune Response To Meningococcal Serogroup B Outer Membrane Vesicle (Omv) Vaccine When Administered Intramuscularly To Adults & Adolescents Completed NCT00774384 Phase 2
26 Open and Exploratory Trial to Investigate the Pharmacokinetic of Ceftobiprole Medocaril in Patients With CSF Device Recruiting NCT03317093 Phase 2 Ceftobiprole Medocaril
27 Evaluation of Cerebrospinal Fluid Concentration of Daptomycin (Cubicin¬) in Pediatric Patients With Gram-positive Bacterial Meningitis, Concurrently Receiving Standard Antimicrobial Therapy Terminated NCT01522105 Phase 1 Daptomycin
28 Association of Serum 25-hydroxyvitamin D Levels and Outcomes in Children With Bacterial Meningitis Unknown status NCT02467309
29 Surveillance of Hospitalised Pneumonia and Bacterial Meningitis in Tône District, Togo, 2010-2013 Unknown status NCT01747369
30 Diagnosis Value of Procalcitonin, Interleukin-6, AgiotensininⅡin the Cerebrospinal Fluid of Patients With Central Nervous System Infective Diseases Unknown status NCT02278016
31 Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis Completed NCT03595761
32 Bacterial Meningitis in Adults: Analysis of the Determinants of Mortality and Neurosensory Sequelae Completed NCT01730690
33 Lactamica 7: Defining the Immune Response to Nasopharyngeal Colonisation by the Commensal Neisseria Lactamica Completed NCT03633474 Early Phase 1
34 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Completed NCT01431326 The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
35 Neisseria Meningitidis Burden of Disease Completed NCT01730391
36 The Relevance of Performing Lumbar Puncture in Infants Aged 3 to 12 Months With First Episode of Febrile Convulsion Completed NCT01443611
37 Procalcitonin (PCT) as a Diagnostic Marker of Bacterial Infection in the Patients Admitted for Fever and/or Inflammatory Syndrome to the Internal Medicine Department Completed NCT02898948
38 Intracranial Hypertension Detection Using Optic Nerve Sheath Diameter Measurement in Children Completed NCT01796015
39 Baby-Friendly Community Health Services Evaluation: A Cluster Randomised Controlled Study Completed NCT01025362
40 The Effectiveness of Video Discharge Instructions for Acute Otitis Media on Knowledge Acquisition and Clinical Outcomes: a Randomized Controlled Trial Completed NCT02788422
41 A Prospective Randomized Controlled Trial to Investigate the Effects of Training Emergency Medical Services (EMS) Personnel in Recognizing and Initiating Treatment in the Prehospital Setting Together With Early Administration of Antibiotics for Patients Suspected of (Severe) Sepsis and Septic Shock Completed NCT01988428 Ceftriaxone 2000 mg
42 The Impact of a Breastfeeding Support Intervention on Breastfeeding Duration in Jaundiced Infants Admitted to a Tertiary Care Centre: a Randomized Controlled Trial. Completed NCT00966719
43 Validation of a Vital Signs and Symptoms Decision Tree and the Effect of a Point-of- Care CRP Test, Oxygen Saturation, a Brief Intervention and a Parent Leaflet on Diagnosing, Antibiotic Prescribing Rate and Parental Satisfaction in Acutely Ill Children in Primary Care." Completed NCT02024282
44 A European, Multicentre, Non-comparative, Non-interventional, Prospective Clinical Registry to Evaluate the Clinical Outcome and Safety of the Treatment of Severely Infected Patients With Fosfomycin i.v. Recruiting NCT02979951
45 A Multicenter Prospective Cohort Study on Neonatal Bacterial Meningitis Recruiting NCT03499652
46 Application of Next Generation Sequencing Technique in Pediatric Bacterial Meningitis Recruiting NCT03953638
47 Systematic Search for Primary Immunodeficiency in Adults With Unexplained Recurrent and/or Severe Infections With Encapsulated Bacteria Recruiting NCT02972281
48 A Human Controlled Infection Study to Assess Safety, Colonisation and Immunogenicity Following Nasal Inoculation With Reconstituted Lyophilised Wild Type Neisseria Lactamica Recruiting NCT04135053
49 Challenge of the Nasopharynx With Neisseria Lactamica Expressing the Meningococcal Protein Neisseria Adhesin A (NadA) Recruiting NCT03630250 Early Phase 1
50 Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark Recruiting NCT03418441

Search NIH Clinical Center for Bacterial Meningitis

Cochrane evidence based reviews: meningitis, bacterial

Genetic Tests for Bacterial Meningitis

Anatomical Context for Bacterial Meningitis

MalaCards organs/tissues related to Bacterial Meningitis:

40
Brain, Testes, Bone, Spinal Cord, Pituitary, Endothelial, Heart

Publications for Bacterial Meningitis

Articles related to Bacterial Meningitis:

(show top 50) (show all 7214)
# Title Authors PMID Year
1
Adenosine deaminase and tuberculous meningitis--a systematic review with meta-analysis. 54 61
20001225 2010
2
Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis. 54 61
19814625 2009
3
[Laboratory diagnosis of bacterial meningitis: usefulness of various tests for the determination of the etiological agent]. 54 61
19398286 2009
4
Markers that predict serious bacterial infection in infants under 3 months of age presenting with fever of unknown origin. 54 61
19158133 2009
5
C-reactive protein as an indicator of aqueductal gliosis and hydrocephaly in neonatal meningitis. 54 61
18581011 2008
6
Bacterial meningitis: rapid diagnosis and microbial profile: a multicentered study. 54 61
19301695 2008
7
Rarity of bacterial and viral meningitis in areas of Western Greece with fewer than 2,000 inhabitants. 54 61
18219135 2008
8
TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. 54 61
17947688 2007
9
Fibronectin is elevated in the cerebrospinal fluid of patients suffering from bacterial meningitis and enhances inflammation caused by bacterial products in primary mouse microglial cell cultures. 54 61
17561936 2007
10
beta-Glucuronidase activity in cerebrospinal fluid pleocytosis due to urinary tract infection. 54 61
17577341 2007
11
[Changes and clinical significance of Toll-like receptor 2 and 4 expression in neonatal infections]. 54 61
17456342 2007
12
Lipopolysaccharide binding protein is a potential marker for invasive bacterial infections in children. 54 61
17259880 2007
13
Properdin deficiency in a boy with fulminant meningococcal septic shock. 54 61
17062484 2006
14
Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults. 54 61
17333738 2006
15
Cytokines and adhesion molecules expression in the brain in human cerebral malaria. 54 61
16705810 2005
16
[Concentration of proinflammatory cytokines (TNF-alpha, IL-8) in the cerebrospinal fluid and the course of bacterial meningitis]. 54 61
15230146 2004
17
Chemotactic activity of CXCL5 in cerebrospinal fluid of children with bacterial meningitis. 54 61
14644041 2003
18
Beta-glucuronidase in the diagnosis of bacterial meningitis and response to treatment. 54 61
14696846 2003
19
New and old diagnostic markers of meningitis in cerebrospinal fluid (CSF). 54 61
12909299 2003
20
[Acute meningitidis, acute phase proteins and procalcitonin]. 54 61
12702467 2003
21
Interleukin-8 levels in children with bacterial, tuberculous and aseptic meningitis. 54 61
12003295 2002
22
Interleukin-1beta and tumor necrosis factor-alpha in cerebrospinal fluid of children with bacterial meningitis. 54 61
11508533 2001
23
Levels of three inflammation markers, C-reactive protein, serum amyloid A protein and procalcitonin, in the serum and cerebrospinal fluid of patients with meningitis. 54 61
11763415 2001
24
Significance of cerebrospinal fluid adenosine deaminase isoenzymes in tuberculous (TB) meningitis. 54 61
11574950 2001
25
Serum C-reactive protein in the differential diagnosis of childhood meningitis. 54 61
11059546 2000
26
Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits. 54 61
10992482 2000
27
Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. 54 61
10913401 2000
28
Value of cerebrospinal fluid leukocyte aggregation in distinguishing the causes of meningitis in children. 54 61
10643853 2000
29
Cerebrospinal fluid tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and interleukin-8 as diagnostic markers of cerebrospinal fluid infection in neurosurgical patients. 54 61
10667525 2000
30
C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. 54 61
10356141 1999
31
[Quantitative levels of serum amyloid A protein and other proteins in cerebrospinal fluid and serum of patients with meningitis]. 54 61
9800479 1998
32
C-reactive protein and bacterial meningitis: a meta-analysis. 54 61
9819187 1998
33
Chemokines and chemotaxis of leukocytes in infectious meningitis. 54 61
9626995 1998
34
Etiology of central nervous system infections in the Philippines and the role of serum C-reactive protein in excluding acute bacterial meningitis. 54 61
10225986 1998
35
The production of macrophage inflammatory protein-1alpha in the cerebrospinal fluid at the initial stage of meningitis in children. 54 61
9396559 1997
36
Levels of interleukin-6, CRP and alpha 2 macroglobulin in cerebrospinal fluid (CSF) and serum as indicator of blood-CSF barrier damage. 54 61
9350334 1997
37
[The role of carbapenems in the treatment of nosocomial infection]. 54 61
9410075 1997
38
The pattern of interleukin-1beta (IL-1beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections. 54 61
9242541 1997
39
TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis. 54 61
9218605 1997
40
[Bacterial meningitis and CSF cytokines]. 54 61
15034315 1997
41
Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis. 54 61
9223915 1997
42
Increased activity of lysosomal acid hydrolases in the cell-free cerebrospinal fluid of bacterial meningitis. 54 61
9029645 1997
43
Chemokines in the cerebrospinal fluid of patients with meningitis. 54 61
8764560 1996
44
Inflammatory cytokines in CSF in bacterial meningitis: association with altered blood flow velocities in basal cerebral arteries. 54 61
8676162 1996
45
Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in children. 54 61
8699576 1996
46
C-reactive protein as an indicator of complications in bacterial meningitis. 54 61
8979584 1996
47
Diffusion of 3-quaternary ammonium cephem antibiotics into cerebrospinal fluid of patients with bacterial meningitis. 54 61
8738850 1996
48
Cerebrospinal fluid interleukin-6, interleukin-8, and tumor necrosis factor-alpha in children with central nervous system infections. 54 61
8936005 1996
49
[C-reactive protein (CRP) and its significance in purulent meningitis]. 54 61
8584095 1995
50
Acute phase proteins in serum and cerebrospinal fluid in the course of bacterial meningitis. 54 61
8521602 1995

Variations for Bacterial Meningitis

Expression for Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for Bacterial Meningitis

Pathways related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 TNF TLR9 TLR4 TLR2 S100B MMP9
2
Show member pathways
13.52 TNF TLR9 TLR4 TLR2 IL6 IL1B
3
Show member pathways
13.44 TNF MMP9 IL6 IL1B IL10 CXCL8
4
Show member pathways
13.35 TNF IL6 IL1B IL10 CXCL8 CXCL1
5
Show member pathways
13.17 TNF TLR9 TLR4 TLR2 MMP9 IL6
6
Show member pathways
13.06 TNF TLR4 TLR2 IL6 IL1B CXCL8
7
Show member pathways
12.94 TNF IL6 IL1B IL10 CXCL8 C3
8
Show member pathways
12.94 TNF TLR9 TLR4 TLR2 IL6 IL1B
9 12.92 TNF TLR9 TLR2 IL6 IL1B CFP
10
Show member pathways
12.89 TNF TLR4 S100B IL6 IL1B CXCL8
11
Show member pathways
12.8 TNF TLR9 TLR4 TLR2 IL6 IL1B
12
Show member pathways
12.74 TNF TLR9 TLR4 TLR2 IL6 IL1B
13
Show member pathways
12.71 TNF TLR4 TLR2 IL6 IL1B IL10
14
Show member pathways
12.67 TNF IL6 IL1B IL10 CXCL1
15
Show member pathways
12.66 TNF TLR9 TLR4 TLR2 IL1B
16 12.64 TNF TLR9 TLR2 IL1B IL10
17 12.48 TNF TLR4 IL1B CXCL8 C3
18
Show member pathways
12.48 TNF IL6 IL10 CXCL8 CXCL1 CCL4
19
Show member pathways
12.48 TNF TLR2 MMP9 IL6 IL1B CXCL8
20
Show member pathways
12.43 TNF IL6 IL1B CRP ALB
21
Show member pathways
12.41 TNF TLR4 IL6 IL1B CXCL8
22
Show member pathways
12.41 TNF TLR9 TLR4 TLR2 IL6 CXCL8
23 12.4 TNF TLR4 IL6 IL1B CXCL8
24
Show member pathways
12.4 TNF TLR4 TLR2 IL1B IL10 CR1
25 12.39 TNF TLR4 IL6 IL1B CXCL8 CXCL1
26 12.35 TNF TLR4 TLR2 MMP9
27
Show member pathways
12.34 TNF IL6 IL1B IL10 CXCL8
28
Show member pathways
12.34 TNF TLR2 IL6 IL1B CXCL8
29 12.34 TNF TLR9 TLR4 TLR2 MMP9 IL6
30
Show member pathways
12.33 TNF TLR9 IL6 IL1B IL10
31 12.32 TNF IL6 IL1B IL10 CXCL8 AQP4
32
Show member pathways
12.31 TNF TLR9 TLR4 TLR2 IL6 IL1B
33
Show member pathways
12.2 TNF TLR4 TLR2 MMP9 IL6 IL1B
34
Show member pathways
12.17 TLR9 TLR4 TLR2 PIK3C2A IL1B
35 12.17 TNF TLR4 IL6 IL1B IL10 CXCL8
36
Show member pathways
12.16 CRP CR1 CFP C3
37 12.14 TNF MMP9 IL6 IL1B IL10 CXCL8
38
Show member pathways
12.14 TNF TLR9 TLR4 TLR2 IL6 IL1B
39 12.12 TNF MMP9 IL6 IL1B CXCL1
40 12.08 TNF TLR4 IL1B CXCL8 CXCL1 CCL4
41 12.06 TNF TLR9 TLR4 TLR2 IL6 IL1B
42 12.05 TNF TLR4 MMP9 IL6 IL1B CXCL8
43 12.04 IL6 IL1B CXCL8 CXCL1
44 12.02 TNF IL6 IL1B CXCL8
45 12.01 TNF IL6 IL1B CR1
46 11.99 TLR9 TLR4 TLR2 CR1 C3
47
Show member pathways
11.98 TLR4 IL6 CXCL8 CXCL1
48 11.97 TNF TLR4 TLR2 IL6 IL1B CXCL8
49 11.94 TLR4 IL6 IL1B CXCL8 CXCL1 CCL4
50 11.93 TNF TLR4 TLR2 IL6 IL1B IL10

GO Terms for Bacterial Meningitis

Cellular components related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 TNF S100B MMP9 MMP8 IL6 IL1B
2 extracellular region GO:0005576 9.53 TNF TLR9 S100B MMP9 MMP8 IL6
3 tertiary granule lumen GO:1904724 9.46 MMP9 MMP8 CXCL1 CFP
4 specific granule lumen GO:0035580 9.43 MMP8 CXCL1 CFP

Biological processes related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.35 TLR9 TLR4 TLR2 IL6 IL1B IL10
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.28 TNF TLR9 TLR4 TLR2 IL6 IL1B
3 neutrophil degranulation GO:0043312 10.14 TLR2 MMP9 MMP8 CXCL1 CR1 CFP
4 negative regulation of cell proliferation GO:0008285 10.13 TLR2 IL6 IL1B IL10 CXCL8 CXCL1
5 innate immune response GO:0045087 10.13 TLR9 TLR4 TLR2 S100B CRP CR1
6 positive regulation of gene expression GO:0010628 10.1 TNF TLR9 TLR4 TLR2 MMP8 IL6
7 defense response to bacterium GO:0042742 10.08 TNF TLR9 TLR4 IL10 CFP
8 positive regulation of protein phosphorylation GO:0001934 10.03 TNF MMP9 IL1B C3
9 response to lipopolysaccharide GO:0032496 10.03 TLR4 TLR2 IL1B IL10
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.03 TNF TLR9 TLR4 S100B IL1B
11 cytokine-mediated signaling pathway GO:0019221 10.01 TNF MMP9 IL6 IL1B IL10 CXCL8
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.99 TNF IL6 IL1B IL10
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.99 TNF TLR9 TLR4 TLR2 IL6 IL1B
14 defense response to Gram-positive bacterium GO:0050830 9.98 TNF TLR2 IL6 CRP
15 cellular response to lipopolysaccharide GO:0071222 9.98 TNF TLR4 IL6 IL1B IL10 CXCL8
16 cellular response to interferon-gamma GO:0071346 9.97 TLR4 TLR2 CCL4 AQP4
17 neutrophil chemotaxis GO:0030593 9.95 IL1B CXCL8 CXCL1 CCL4
18 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR9 TLR4 TLR2 IL1B
19 positive regulation of JNK cascade GO:0046330 9.93 TNF TLR9 TLR4 MMP8 IL1B
20 chemokine-mediated signaling pathway GO:0070098 9.92 CXCL8 CXCL1 CCL4
21 response to glucocorticoid GO:0051384 9.92 TNF S100B IL6 IL10
22 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.91 TNF TLR9 TLR4
23 positive regulation of tumor necrosis factor production GO:0032760 9.9 TLR9 TLR4 TLR2
24 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.9 TNF MMP9 IL10
25 positive regulation of phagocytosis GO:0050766 9.89 TNF IL1B C3
26 positive regulation of interferon-gamma production GO:0032729 9.89 TNF TLR4 IL1B
27 toll-like receptor signaling pathway GO:0002224 9.89 TLR9 TLR4 TLR2
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 MMP8 IL1B
29 negative regulation of interleukin-6 production GO:0032715 9.88 TNF TLR9 TLR4 IL10
30 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.87 TLR9 TLR4 TLR2
31 positive regulation of JAK-STAT cascade GO:0046427 9.87 TNF IL6 IL10
32 positive regulation of vascular endothelial growth factor production GO:0010575 9.87 IL6 IL1B C3
33 positive regulation of interleukin-6 secretion GO:2000778 9.87 TNF TLR4 TLR2 IL1B
34 negative regulation of neurogenesis GO:0050768 9.86 TNF IL6 IL1B
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.86 TNF TLR4 TLR2 IL1B
36 positive regulation of interleukin-12 production GO:0032735 9.85 TLR9 TLR4 TLR2
37 positive regulation of interferon-beta production GO:0032728 9.85 TLR9 TLR4 TLR2
38 positive regulation of interleukin-10 production GO:0032733 9.84 TLR9 TLR4 TLR2
39 leukocyte chemotaxis GO:0030595 9.83 IL10 CXCL8 CXCL1
40 positive regulation of glial cell proliferation GO:0060252 9.82 TNF IL6 IL1B
41 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.81 TNF IL1B IL10
42 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.8 TLR9 TLR4 TLR2
43 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 TNF TLR9 TLR4 TLR2 MMP8 IL1B
44 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.79 TNF TLR9 TLR4
45 I-kappaB phosphorylation GO:0007252 9.79 TLR9 TLR4 TLR2
46 regulation of neuroinflammatory response GO:0150077 9.78 MMP9 MMP8 IL6
47 positive regulation of neuroinflammatory response GO:0150078 9.78 TNF MMP8 IL6 IL1B
48 negative regulation of lipid storage GO:0010888 9.77 TNF IL6 CRP
49 positive regulation of interleukin-8 production GO:0032757 9.77 TNF TLR9 TLR4 TLR2 IL1B
50 response to molecule of bacterial origin GO:0002237 9.76 TLR9 TLR2 IL10 CXCL8

Molecular functions related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 TNF TLR4 TLR2 S100B MMP9 CRP
2 chemokine activity GO:0008009 9.43 CXCL8 CXCL1 CCL4
3 cytokine activity GO:0005125 9.17 TNF IL6 IL1B IL10 CXCL8 CXCL1
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2

Sources for Bacterial Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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