MCID: BCT007
MIFTS: 61

Bacterial Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Bacterial Meningitis

MalaCards integrated aliases for Bacterial Meningitis:

Name: Bacterial Meningitis 12 77 54 15 17 3
Meningitis, Bacterial 54 45 74
Meningitis Bacterial 56

Classifications:



External Ids:

Disease Ontology 12 DOID:9470
ICD9CM 36 320 320.9
MeSH 45 D016920
NCIt 51 C118297
SNOMED-CT 69 95883001
ICD10 34 G00 G00.9
UMLS 74 C0085437

Summaries for Bacterial Meningitis

CDC : 3 Bacterial meningitis is very serious and can be deadly. Death can occur in as little as a few hours. Most people recover from meningitis. However, permanent disabilities (such as brain damage, hearing loss, and learning disabilities) can result from the infection.

MalaCards based summary : Bacterial Meningitis, also known as meningitis, bacterial, is related to streptococcal meningitis and viral meningitis. An important gene associated with Bacterial Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 A meningitis that has material basis in a bacterial infection.

Wikipedia : 77 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Bacterial Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 464)
# Related Disease Score Top Affiliating Genes
1 streptococcal meningitis 32.9 CFP CRP TNF
2 viral meningitis 32.4 CRP CXCL8 IL6
3 aseptic meningitis 32.4 CXCL8 IL10 IL1B TNF
4 cerebral palsy 31.2 IL1B IL6 MMP8 TNF
5 meningitis 31.1 CFP CRP CXCL8 IL10 IL1B IL6
6 haemophilus influenzae 31.0 CXCL8 IL1B TLR2 TNF
7 tuberculous meningitis 30.5 CXCL8 MMP9 TLR2 TNF
8 brain injury 30.4 IL10 IL6 S100B
9 crohn's disease 30.2 CRP IL10 TLR9 TNF
10 neisseria meningitidis infection 30.1 CFP TLR2 TLR4
11 acute cystitis 30.1 CRP CXCL8 IL6
12 brain edema 30.1 IL1B IL6 MMP9
13 diverticulitis 30.1 CRP MMP9 TNF
14 traumatic brain injury 30.0 IL10 IL6 S100B
15 hematopoietic stem cell transplantation 29.9 IL10 IL6 TNF
16 apnea, obstructive sleep 29.9 CRP IL6 TNF
17 cholangitis 29.9 CRP IL6 TNF
18 infective endocarditis 29.8 CRP IL6 TLR2 TNF
19 scrub typhus 29.7 CRP IL10 IL1B TLR2 TLR4 TNF
20 septic arthritis 29.7 CRP CXCL8 TLR2 TLR4 TLR9
21 reactive arthritis 29.7 CRP IL10 MMP8 TNF
22 arthritis 29.7 CXCL8 IL10 IL1B IL6 MMP9 TNF
23 suppurative otitis media 29.6 CRP IL1B TLR2 TLR4 TLR9
24 myeloma, multiple 29.4 CRP CXCL8 IL6 TLR9 TNF
25 otitis media 29.4 CXCL8 IL10 IL1B IL6 TLR2 TLR4
26 tonsillitis 29.4 CXCL8 IL1B IL6 TLR9 TNF
27 osteomyelitis 29.4 CXCL8 IL10 IL1B IL6 TNF
28 endocarditis 29.4 CRP CXCL8 IL10 IL6 PIK3C2A TLR2
29 human immunodeficiency virus infectious disease 29.3 IL10 IL6 S100B TLR9 TNF
30 pertussis 29.3 IL10 IL1B IL6 TLR4 TNF
31 common variable immunodeficiency 29.3 IL10 IL6 TLR2 TLR9 TNF
32 multiple sclerosis 29.2 IL10 IL1B IL6 MMP9 PTGDS TNF
33 sleep apnea 29.1 CRP CXCL8 IL1B IL6 S100B TNF
34 peritonitis 29.0 CRP CXCL8 IL10 IL1B IL6 TLR2
35 diabetes mellitus 28.9 CRP IL1B IL6 PIK3C2A PTGDS TNF
36 human immunodeficiency virus type 1 28.6 CFP CR1 IL10 IL6 S100B TNF
37 systemic lupus erythematosus 28.5 CR1 CRP IL10 IL1B IL6 TLR2
38 pneumonia 28.4 CRP CXCL8 IL10 IL1B IL6 PIK3C2A
39 bacterial infectious disease 28.3 CFP CRP CXCL8 IL10 IL1B IL6
40 malaria 28.3 CR1 CRP CXCL8 IL10 IL1B IL6
41 haemophilus meningitis 11.6
42 meningococcal infection 11.5
43 meningococcal meningitis 11.1
44 syphilitic meningitis 11.1
45 listeria meningitis 11.1
46 pneumococcal meningitis 10.8
47 staphylococcal toxic shock syndrome 10.5 IL1B TNF
48 endomyocardial fibrosis 10.5 IL10 TNF
49 multifocal choroiditis 10.5 IL10 TNF
50 punctate inner choroidopathy 10.5 IL10 TNF

Comorbidity relations with Bacterial Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to Bacterial Meningitis

Symptoms & Phenotypes for Bacterial Meningitis

MGI Mouse Phenotypes related to Bacterial Meningitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 CFP CRP IL10 IL1B IL6 MMP8
2 cardiovascular system MP:0005385 10.16 CFP CRP IL10 IL1B IL6 MMP9
3 behavior/neurological MP:0005386 10.13 CKB IL10 IL6 MMP9 PTGDS S100B
4 immune system MP:0005387 10.13 CFP CRP IL10 IL1B IL6 MMP8
5 hematopoietic system MP:0005397 10.1 IL10 IL1B IL6 MMP9 PIK3C2A PTGDS
6 digestive/alimentary MP:0005381 9.98 IL10 IL6 MMP9 TLR2 TLR4 TLR9
7 integument MP:0010771 9.91 IL10 IL1B IL6 MMP9 PTGDS S100B
8 neoplasm MP:0002006 9.81 IL10 IL1B IL6 MMP8 MMP9 PTGDS
9 nervous system MP:0003631 9.61 CKB IL10 IL1B IL6 MMP9 PTGDS
10 skeleton MP:0005390 9.28 CFP IL10 IL1B IL6 MMP9 PTGDS

Drugs & Therapeutics for Bacterial Meningitis

Drugs for Bacterial Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 226)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
3
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
4
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
5
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 456256 5742673
6
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
7
Ceftriaxone Approved Phase 4,Phase 3,Phase 1 73384-59-5 5479530 5361919
8
Azathioprine Approved Phase 4 446-86-6 2265
9
Ciprofloxacin Approved, Investigational Phase 4,Early Phase 1,Not Applicable 85721-33-1 2764
10
Amikacin Approved, Investigational, Vet_approved Phase 4 37517-28-5 37768
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
12 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
13 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
14 Hormones Phase 4,Phase 2,Phase 3
15
protease inhibitors Phase 4,Phase 2,Phase 3
16 Autonomic Agents Phase 4,Phase 2,Phase 3
17 BB 1101 Phase 4,Phase 2,Phase 3
18 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
19 Hormone Antagonists Phase 4,Phase 2,Phase 3
20 Antiemetics Phase 4,Phase 2,Phase 3
21 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
22 glucocorticoids Phase 4,Phase 2,Phase 3
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
24 Anticonvulsants Phase 4
25 Diuretics, Potassium Sparing Phase 4
26 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
27 Sodium Channel Blockers Phase 4
28 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
30 Immunoglobulins Phase 4,Phase 3,Phase 2,Not Applicable
31 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Antibodies Phase 4,Phase 3,Phase 2,Not Applicable
33 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
35 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1,Phase 2,Not Applicable
36 Analgesics Phase 4,Phase 3,Phase 2
37 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
38 Antipyretics Phase 4,Phase 3,Phase 2
39 beta-Lactams Phase 4
40 Lactams Phase 4
41 Gentamicins Phase 4,Phase 3
42 penicillins Phase 4,Phase 3
43 Antimetabolites, Antineoplastic Phase 4
44 Antirheumatic Agents Phase 4,Phase 2
45 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
46 Antimetabolites Phase 4,Not Applicable
47 Immunosuppressive Agents Phase 4
48 gamma-Globulins Phase 4,Phase 3,Phase 2
49 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
50 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 170)
# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
2 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
3 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
4 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
5 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
6 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
7 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
8 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
9 Ciprofloxacin for the Prevention of Meningococcal Meningitis Completed NCT02724046 Phase 4 Ciprofloxacin
10 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
11 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
12 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
13 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
14 A Sourcing Study to Collect Human Blood Samples From Healthy Adults Recruiting NCT03493919 Phase 4
15 Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea Active, not recruiting NCT02864927 Phase 4
16 Ciprofloxacin for the Prevention of Meningococcal Meningitis 2018 Not yet recruiting NCT03431675 Phase 4 Ciprofloxacin
17 Evaluation of Safety and Immunogenicity of Meningococcal B and Meningococcal ACWY Vaccine in at Risk Population Not yet recruiting NCT03682939 Phase 4
18 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
19 Amikacin Penetration Into the Cerebrospinal Fluid Withdrawn NCT00362245 Phase 4 Systemic and Intra-Thecal Amikacin Therapy
20 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
21 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
22 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 75 Years of Age in India Completed NCT01547715 Phase 3
23 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 18 Years in Taiwan Completed NCT01410474 Phase 3
24 Safety and Immunogenicity Study of MenC-TT Vaccine (NeisVac-C) in Toddlers Previously Immunized With PCV7 (Prevenar®) Completed NCT00617760 Phase 3
25 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
26 DTaP-IPV/Hib Vaccine Primary & Booster Vaccinations Versus Co-administration of DTaP-IPV and Hib Vaccine in Japanese Infants Completed NCT02274285 Phase 3
27 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
28 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
29 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
30 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
31 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
32 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
33 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
34 A Study of Meningococcal Vaccine, Menactra® in Healthy Subjects in India Completed NCT01086969 Phase 3
35 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
36 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
37 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
38 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
39 Study to Assess Potential Immune Interference When GlaxoSmithKline (GSK) Biologicals' MenABCWY Vaccine is Administered to Healthy Subjects Aged 10-25 Years Completed NCT03587207 Phase 2, Phase 3
40 Immunogenicity and Safety of a Meningococcal Conjugate Vaccine Given Concomitantly With Other Vaccines in Toddlers Completed NCT03205371 Phase 3
41 Study of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Administered in Children Aged 2 to 9 Years Completed NCT03077438 Phase 3
42 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Toddlers Completed NCT02955797 Phase 3
43 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adults 56 Years and Older Completed NCT02842866 Phase 3
44 Immune Lot Consistency, Immunogenicity, and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Completed NCT02842853 Phase 3
45 Immunogenicity and Safety of a Booster Dose of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Completed NCT02752906 Phase 3
46 Safety and Blood Donations in Adults Vaccinated With rMenB+OMV NZ. Completed NCT02305446 Phase 3
47 Antibody Persistence, and Safety and Tolerability of a Booster Dose of the Meningococcal B Vaccine After the Completion of the Vaccination Course in Study V72_28 Completed NCT01894919 Phase 3
48 A Global Phase 3 Safety Study of 120 mcg rLP2086 Vaccine in Adolescents and Young Adults Aged 10 to 25 Years Completed NCT01352793 Phase 3
49 Comparison of Two Meningococcal ACWY Conjugate Vaccines Completed NCT01192997 Phase 2, Phase 3
50 Evaluation of Meningococcal Immune Response Among Children Who Previously Received MenACWY Conjugate Vaccine Completed NCT01148017 Phase 3

Search NIH Clinical Center for Bacterial Meningitis

Cochrane evidence based reviews: meningitis, bacterial

Genetic Tests for Bacterial Meningitis

Anatomical Context for Bacterial Meningitis

MalaCards organs/tissues related to Bacterial Meningitis:

42
Brain, Testes, Spinal Cord, Liver, Pituitary, Neutrophil, Myeloid

Publications for Bacterial Meningitis

Articles related to Bacterial Meningitis:

(show top 50) (show all 2854)
# Title Authors Year
1
Not So Novel Complication of Adjunctive Steroids in Patients With Bacterial Meningitis. ( 30653071 )
2019
2
Diagnosis of bacterial meningitis in Ghana: Polymerase chain reaction versus latex agglutination methods. ( 30653582 )
2019
3
Cerebrospinal fluid procalcitonin predicts Gram-negative bacterial meningitis in patients with empiric antibiotic pretreatment. ( 30674333 )
2019
4
MiR-301a-3p in the pathogenesis of bacterial meningitis by targeting Cx43. ( 30703072 )
2019
5
MicroRNA-135a participates in the development of astrocytes derived from bacterial meningitis by downregulating HIF-1α. ( 30726113 )
2019
6
Comparing Single vs. Combined Cerebrospinal Fluid Parameters for Diagnosing Full-Term Neonatal Bacterial Meningitis. ( 30728800 )
2019
7
Multiplex-PCR for diagnosis of bacterial meningitis. ( 30796713 )
2019
8
Cerebrospinal fluid/blood glucose point-of-care testing ratio for diagnosing bacterial meningitis in a limited medical resource setting. ( 30801430 )
2019
9
Etiology and Clinical Features of Full-Term Neonatal Bacterial Meningitis: A Multicenter Retrospective Cohort Study. ( 30815433 )
2019
10
Bacterial meningitis and cauda equina syndrome after trans-sacral epiduroscopic laser decompression: A case report. ( 30882691 )
2019
11
Prevalence of Bacteremia and Bacterial Meningitis in Febrile Neonates and Infants in the Second Month of Life: A Systematic Review and Meta-analysis. ( 30901044 )
2019
12
Neonatal bacterial meningitis: a systematic review of European available data. ( 29160642 )
2019
13
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
14
Duplex recombinase polymerase amplification assays incorporating competitive internal controls for bacterial meningitis detection. ( 29378166 )
2018
15
Cerebrospinal Fluid Lactate as a Prognostic Indicator in Postneurosurgical Bacterial Meningitis and Use of Intrathecal Colistin. ( 29743769 )
2018
16
Delayed Cerebral Injury in Adults With Bacterial Meningitis: A Novel Complication of Adjunctive Steroids? ( 29746358 )
2018
17
A world without bacterial meningitis: how genomic epidemiology can inform vaccination strategy. ( 29636909 )
2018
18
Adult-Onset Recurrent Bacterial Meningitis: Immunological Red Herrings. ( 29401276 )
2018
19
Using Predictive Model for Screening Bacterial Meningitis in National Surveillance System in Iran. ( 29968622 )
2018
20
Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. ( 29628177 )
2018
21
Detection of Bacterial Meningitis Pathogens by PCR-Mass Spectrometry in Cerebrospinal Fluid. ( 29945321 )
2018
22
<i>Burkholderia multivorans:</i> A rare yet emerging cause of bacterial meningitis. ( 29619322 )
2018
23
Correction to: Meta-analysis of adjunctive dexamethasone to improve clinical outcome of bacterial meningitis in children. ( 29322336 )
2018
24
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
25
Repeated Audiometry After Bacterial Meningitis: Consequences for Future Management. ( 29659414 )
2018
26
Osmotic therapies added to antibiotics for acute bacterial meningitis. ( 29405037 )
2018
27
Elevations of novel cytokines in bacterial meningitis in infants. ( 29394248 )
2018
28
Mathematical Modelling of Bacterial Meningitis Transmission Dynamics with Control Measures. ( 29780431 )
2018
29
Cerebrospinal fluid lactate as a marker to differentiate between community-acquired acute bacterial meningitis and aseptic meningitis/encephalitis in adults: a Danish prospective observational cohort study. ( 29490540 )
2018
30
Anaerobic bacterial meningitis in adults. ( 29396061 )
2018
31
Bacterial meningitis in neonates and infants - the sonographic picture. ( 29844943 )
2018
32
Variation in coagulation and fibrinolysis genes evaluated for their contribution to cerebrovascular complications in adults with bacterial meningitis in the Netherlands. ( 29746949 )
2018
33
Evaluation of an Internally Controlled Multiplex Tth Endonuclease Cleavage Loop-Meditated Isothermal Amplification (TEC-LAMP) Assay for the Detection of Bacterial Meningitis Pathogens. ( 29425124 )
2018
34
The clinical characteristics of adult bacterial meningitis caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas species: A clinical comparison with Ps. aeruginosa meningitis. ( 29310816 )
2018
35
Ectopic Prolactinoma Presenting as Bacterial Meningitis: A Diagnostic Conundrum. ( 29378345 )
2018
36
Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis. ( 29751358 )
2018
37
Biot's breathing associated with acute bacterial meningitis in a child. ( 29960974 )
2018
38
Diagnostic scoring system for tuberculous meningitis among adult patients with non-suppurative and non-bacterial meningitis. ( 29705393 )
2018
39
Burden of bacterial meningitis in India: Preliminary data from a hospital based sentinel surveillance network. ( 29768458 )
2018
40
Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data. ( 29754263 )
2018
41
Bacterial Meningitis as a Cause of Death in Lung Transplant Donors: Early Outcomes in Recipients. ( 29862567 )
2018
42
Global etiology of bacterial meningitis: A systematic review and meta-analysis. ( 29889859 )
2018
43
Clinical Characteristics and Risk Factors for Poor Outcome in Infants Less Than 90 Days of Age with Bacterial Meningitis in the United Kingdom and Ireland. ( 29384979 )
2018
44
Temporal trends in paediatric bacterial meningitis in a tropical Australian region: 1992-2014. ( 29754466 )
2018
45
Meta-analysis of adjunctive dexamethasone to improve clinical outcome of bacterial meningitis in children. ( 29188363 )
2018
46
Intra-arterial Injection of Fasudil Hydrochloride for Cerebral Vasospasm Secondary to Bacterial Meningitis. ( 30327749 )
2018
47
Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis. ( 30328110 )
2018
48
Pediatric bacterial meningitis: an update on early identification and management. ( 30358380 )
2018
49
Anterior spinal cord syndrome as a rare complication of acute bacterial meningitis in an adult. ( 30361450 )
2018
50
Acute Community-Acquired Bacterial Meningitis. ( 30366556 )
2018

Variations for Bacterial Meningitis

Expression for Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for Bacterial Meningitis

Pathways related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 CFP CR1 CRP CXCL8 IL10 IL1B
2
Show member pathways
13.45 CXCL8 IL10 IL1B IL6 TLR2 TLR4
3
Show member pathways
13.26 CXCL8 IL10 IL1B IL6 TLR2 TLR4
4
Show member pathways
13.2 IL1B PIK3C2A TLR2 TLR4 TLR9 TNF
5
Show member pathways
13.02 CXCL8 IL1B IL6 MMP9 TLR2 TLR4
6
Show member pathways
12.87 CXCL8 IL10 IL1B IL6 TNF
7
Show member pathways
12.82 CXCL8 IL1B IL6 S100B TLR4 TNF
8
Show member pathways
12.77 IL1B IL6 TLR2 TLR4 TLR9 TNF
9
Show member pathways
12.67 IL10 IL1B IL6 TLR2 TLR4 TNF
10
Show member pathways
12.65 IL1B TLR2 TLR4 TLR9 TNF
11
Show member pathways
12.63 CFP CXCL8 IL1B IL6 TLR2 TLR4
12 12.62 IL10 IL1B TLR2 TLR9 TNF
13
Show member pathways
12.44 IL10 IL1B IL6 TNF
14
Show member pathways
12.44 CXCL8 IL1B IL6 MMP9 TLR2 TNF
15
Show member pathways
12.39 CXCL8 IL1B IL6 TLR4 TNF
16
Show member pathways
12.37 CXCL8 IL6 TLR2 TLR4 TLR9 TNF
17
Show member pathways
12.36 CRP IL1B IL6 TNF
18
Show member pathways
12.36 CR1 IL10 IL1B TLR2 TLR4 TNF
19 12.32 MMP9 TLR2 TLR4 TNF
20
Show member pathways
12.32 CXCL8 IL10 IL1B IL6 TNF
21
Show member pathways
12.31 CXCL8 IL1B IL6 TLR2 TNF
22
Show member pathways
12.29 IL10 IL1B IL6 TLR9 TNF
23
Show member pathways
12.29 CXCL8 IL1B MMP8 MMP9 TLR2 TLR4
24 12.28 IL6 MMP9 TLR2 TLR4 TLR9 TNF
25 12.26 CXCL8 IL10 IL1B IL6 TNF
26
Show member pathways
12.17 CXCL8 IL1B IL6 TLR2 TLR4 TLR9
27
Show member pathways
12.13 IL1B PIK3C2A TLR2 TLR4 TLR9
28
Show member pathways
12.11 IL1B IL6 MMP9 TLR2 TLR4 TNF
29 12.07 CXCL8 IL1B IL6 MMP9 TLR4 TNF
30 12.04 IL1B IL6 MMP9 TNF
31 12.03 CXCL8 IL10 IL1B IL6 MMP9 TNF
32 12.01 CR1 IL10 IL1B IL6 TLR2 TLR4
33 11.99 CXCL8 IL1B IL6 TNF
34 11.98 CR1 IL1B IL6 TNF
35
Show member pathways
11.98 IL10 IL1B IL6 TLR2 TLR4 TLR9
36 11.96 CXCL8 IL1B TLR4 TNF
37 11.94 CXCL8 IL1B IL6
38 11.91 CXCL8 IL1B IL6 TLR4
39
Show member pathways
11.9 MMP8 MMP9 TNF
40 11.9 CR1 TLR2 TLR4 TLR9
41
Show member pathways
11.88 CXCL8 IL6 TLR4
42 11.87 IL10 IL1B IL6 TLR9 TNF
43 11.87 CXCL8 IL1B IL6 TLR2 TLR4 TNF
44 11.84 IL10 IL1B IL6 MMP9 TNF
45 11.8 IL10 IL1B TNF
46 11.78 CXCL8 IL10 IL1B IL6 TLR2 TLR4
47 11.76 CXCL8 IL1B IL6 MMP9 TNF
48
Show member pathways
11.76 CXCL8 IL1B IL6 MMP9 TNF
49 11.73 CXCL8 IL10 IL1B IL6 TLR4 TNF
50 11.71 CXCL8 IL6 MMP9

GO Terms for Bacterial Meningitis

Cellular components related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CFP CRP CXCL8 IL10 IL1B IL6
2 extracellular space GO:0005615 9.4 CFP CKB CRP CXCL8 IL10 IL1B
3 tertiary granule lumen GO:1904724 9.33 CFP MMP8 MMP9

Biological processes related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.99 CXCL8 IL10 IL1B IL6 TLR4 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.97 IL10 IL1B IL6 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 IL1B IL6 TLR2 TLR4 TLR9 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.94 CRP IL6 TLR2 TNF
5 positive regulation of inflammatory response GO:0050729 9.94 TLR2 TLR4 TLR9 TNF
6 positive regulation of JNK cascade GO:0046330 9.92 IL1B MMP8 TLR4 TLR9 TNF
7 defense response to Gram-negative bacterium GO:0050829 9.91 IL6 TLR4 TLR9
8 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.9 TLR4 TLR9 TNF
9 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.88 IL10 MMP9 TNF
10 positive regulation of interferon-gamma production GO:0032729 9.87 IL1B TLR4 TNF
11 toll-like receptor signaling pathway GO:0002224 9.86 TLR2 TLR4 TLR9
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.86 IL1B MMP8 TLR4 TNF
13 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.85 TLR2 TLR4 TLR9
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 IL1B TLR2 TLR4 TNF
15 positive regulation of interferon-beta production GO:0032728 9.84 TLR2 TLR4 TLR9
16 negative regulation of interleukin-6 production GO:0032715 9.84 IL10 TLR4 TLR9 TNF
17 negative regulation of neurogenesis GO:0050768 9.83 IL1B IL6 TNF
18 positive regulation of interleukin-12 production GO:0032735 9.83 TLR2 TLR4 TLR9
19 positive regulation of interleukin-10 production GO:0032733 9.83 TLR2 TLR4 TLR9
20 positive regulation of glial cell proliferation GO:0060252 9.81 IL1B IL6 TNF
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.8 IL10 IL1B TNF
22 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.8 TLR2 TLR4 TLR9
23 response to glucocorticoid GO:0051384 9.8 IL10 IL6 S100B TNF
24 regulation of cytokine secretion GO:0050707 9.79 TLR2 TLR4 TLR9
25 I-kappaB phosphorylation GO:0007252 9.78 TLR2 TLR4 TLR9
26 positive regulation of tumor necrosis factor production GO:0032760 9.77 TLR2 TLR4 TLR9
27 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.77 TLR4 TLR9 TNF
28 positive regulation of interleukin-8 production GO:0032757 9.77 IL1B TLR2 TLR4 TLR9 TNF
29 negative regulation of lipid storage GO:0010888 9.76 CRP IL6 TNF
30 negative regulation of growth of symbiont in host GO:0044130 9.74 IL10 TNF
31 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.74 MMP8 TLR4
32 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.74 IL1B TLR9
33 cellular response to lipoteichoic acid GO:0071223 9.74 TLR2 TLR4
34 endothelial cell apoptotic process GO:0072577 9.73 IL10 TNF
35 positive regulation of chemokine biosynthetic process GO:0045080 9.73 IL1B TNF
36 positive regulation of interferon-beta biosynthetic process GO:0045359 9.73 TLR4 TLR9
37 negative regulation of interleukin-8 production GO:0032717 9.73 IL10 TLR9
38 response to molecule of bacterial origin GO:0002237 9.73 CXCL8 IL10 TLR2 TLR9
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 IL10 TLR4
40 regulation of establishment of endothelial barrier GO:1903140 9.72 IL1B TNF
41 negative regulation of cytokine secretion involved in immune response GO:0002740 9.72 IL10 TNF
42 positive regulation of fever generation GO:0031622 9.71 IL1B TNF
43 positive regulation of interleukin-18 production GO:0032741 9.71 TLR2 TLR9
44 regulation of neuroinflammatory response GO:0150077 9.71 MMP8 MMP9
45 tumor necrosis factor production GO:0032640 9.71 TLR2 TLR9
46 positive regulation of toll-like receptor signaling pathway GO:0034123 9.69 TLR2 TLR9
47 sequestering of triglyceride GO:0030730 9.69 IL1B TNF
48 positive regulation of JUN kinase activity GO:0043507 9.69 TLR9 TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.68 IL1B TNF
50 receptor biosynthetic process GO:0032800 9.68 IL10 TNF

Molecular functions related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 CRP MMP9 S100B TLR2 TLR4 TNF
2 interleukin-1 receptor binding GO:0005149 9.26 IL1B TLR9
3 signaling pattern recognition receptor activity GO:0008329 9.16 TLR2 TLR9
4 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL1B IL6 TNF
5 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4

Sources for Bacterial Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
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35 ICD10 via Orphanet
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38 KEGG
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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