MCID: BCT007
MIFTS: 58

Bacterial Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Bacterial Meningitis

MalaCards integrated aliases for Bacterial Meningitis:

Name: Bacterial Meningitis 12 76 53 3 15
Meningitis, Bacterial 53 44 73
Meningitis Bacterial 55

Classifications:



External Ids:

Disease Ontology 12 DOID:9470
ICD10 33 G00 G00.9
ICD9CM 35 320 320.9
MeSH 44 D016920
NCIt 50 C118297
SNOMED-CT 68 95883001
UMLS 73 C0085437

Summaries for Bacterial Meningitis

Disease Ontology : 12 A meningitis that has material basis in a bacterial infection.

MalaCards based summary : Bacterial Meningitis, also known as meningitis, bacterial, is related to streptococcal meningitis and cerebral palsy. An important gene associated with Bacterial Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are homeostasis/metabolism and cardiovascular system

CDC : 3 Español: Meningitis bacteriana

Wikipedia : 76 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Bacterial Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 464)
# Related Disease Score Top Affiliating Genes
1 streptococcal meningitis 32.6 CFP CRP TNF
2 cerebral palsy 31.6 IL1B IL6 MMP8 TNF
3 meningitis 31.1 ALB CFP CRP CXCL8 IL10 IL1B
4 haemophilus influenzae 30.5 CXCL8 IL1B TLR2 TNF
5 aseptic meningitis 30.4 CXCL8 IL10 IL1B TNF
6 tuberculous meningitis 30.4 CXCL8 MMP9 TLR2 TNF
7 viral meningitis 30.3 CRP CXCL8 IL6
8 brain injury 30.0 IL10 IL6 S100B
9 scrub typhus 30.0 CRP IL10 IL1B TLR2 TNF
10 traumatic brain injury 29.9 IL10 IL6 S100B
11 diverticulitis 29.8 CRP MMP9 TNF
12 suppurative otitis media 29.8 CRP IL1B TLR2 TLR9
13 anterior uveitis 29.8 IL6 TLR2 TNF
14 crohn's disease 29.7 CRP IL10 TLR9 TNF
15 septic arthritis 29.7 CRP CXCL8 TLR2 TLR9
16 reactive arthritis 29.7 CRP IL10 MMP8 TNF
17 pyuria 29.7 ALB CRP CXCL8
18 acute cystitis 29.6 ALB CRP CXCL8 IL6
19 acute cholangitis 29.6 CRP IL6
20 myeloma, multiple 29.5 ALB CRP CXCL8 IL6 TLR9 TNF
21 arthritis 29.5 CXCL8 IL10 IL1B IL6 MMP9 TNF
22 tonsillitis 29.5 CXCL8 IL1B IL6 TLR9 TNF
23 common variable immunodeficiency 29.5 IL10 IL6 TLR2 TLR9 TNF
24 osteomyelitis 29.5 CXCL8 IL10 IL1B IL6 TNF
25 cholangitis 29.5 ALB CRP IL6 TNF
26 brain edema 29.4 ALB IL1B IL6 MMP9
27 otitis media 29.4 ALB CXCL8 IL10 IL1B IL6 TLR2
28 malaria 29.1 ALB CRP CXCL8 IL10 IL1B IL6
29 endocarditis 29.1 ALB CRP CXCL8 IL10 IL6 PIK3C2A
30 multiple sclerosis 29.1 IL10 IL1B IL6 MMP9 PTGDS TLR9
31 systemic lupus erythematosus 29.0 ALB CRP CXCL8 IL10 IL1B IL6
32 peritonitis 28.9 ALB CRP CXCL8 IL10 IL1B IL6
33 pneumonia 28.8 CRP CXCL8 IL10 IL1B IL6 PIK3C2A
34 haemophilus meningitis 11.6
35 meningococcal infection 11.5
36 meningococcal meningitis 11.0
37 syphilitic meningitis 11.0
38 listeria meningitis 11.0
39 pneumococcal meningitis 10.8
40 punctate inner choroidopathy 10.3 IL10 TNF
41 tropical endomyocardial fibrosis 10.3 IL10 TNF
42 endomyocardial fibrosis 10.3 IL10 TNF
43 staphylococcal toxic shock syndrome 10.3 IL1B TNF
44 drug reaction with eosinophilia and systemic symptoms 10.3 CRP TNF
45 mycobacterium chelonae 10.3 CXCL8 TLR2
46 prosthetic joint infection 10.3 IL1B TLR2
47 trench fever 10.3 TLR2 TNF
48 microscopic polyangiitis 10.3 IL10 TNF
49 multifocal choroiditis 10.3 IL10 TNF
50 chronic follicular conjunctivitis 10.2 IL1B MMP9

Comorbidity relations with Bacterial Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to Bacterial Meningitis

Symptoms & Phenotypes for Bacterial Meningitis

MGI Mouse Phenotypes related to Bacterial Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.21 ALB CFP CRP IL10 IL1B IL6
2 cardiovascular system MP:0005385 10.11 CFP CRP IL10 IL1B IL6 MMP9
3 immune system MP:0005387 10.1 CFP CRP IL10 IL1B IL6 MMP8
4 hematopoietic system MP:0005397 10.06 IL10 IL1B IL6 MMP9 PIK3C2A PTGDS
5 digestive/alimentary MP:0005381 9.98 ALB IL10 IL6 MMP9 TLR2 TLR9
6 mortality/aging MP:0010768 9.9 ALB CFP IL10 IL1B IL6 MMP9
7 integument MP:0010771 9.86 IL10 IL1B IL6 MMP9 PTGDS S100B
8 neoplasm MP:0002006 9.61 ALB IL10 IL1B IL6 MMP8 MMP9
9 skeleton MP:0005390 9.23 CFP IL10 IL1B IL6 MMP9 PTGDS

Drugs & Therapeutics for Bacterial Meningitis

Drugs for Bacterial Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 227)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 1177-87-3
3
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
4
Cefoxitin Approved Phase 4,Phase 2 35607-66-0 441199
5
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
6
Cefotaxime Approved Phase 4,Phase 2 63527-52-6 456256 5742673
7
Ceftriaxone Approved Phase 4,Phase 3,Phase 1 73384-59-5 5479530 5361919
8
Azathioprine Approved Phase 4 446-86-6 2265
9
Ciprofloxacin Approved, Investigational Phase 4,Early Phase 1,Not Applicable 85721-33-1 2764
10
Amikacin Approved, Investigational, Vet_approved Phase 4 37517-28-5 37768
11 Hormone Antagonists Phase 4,Phase 2,Phase 3
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
13 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
14 Autonomic Agents Phase 4,Phase 2,Phase 3
15 Hormones Phase 4,Phase 2,Phase 3
16 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
17 Antiemetics Phase 4,Phase 2,Phase 3
18 BB 1101 Phase 4,Phase 2,Phase 3
19 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
20
protease inhibitors Phase 4,Phase 2,Phase 3
21 glucocorticoids Phase 4,Phase 2,Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
23 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
24 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
25 Diuretics, Potassium Sparing Phase 4
26 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
27 Sodium Channel Blockers Phase 4
28 Anticonvulsants Phase 4
29 Antibodies Phase 4,Phase 3,Phase 2,Not Applicable
30 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Immunoglobulins Phase 4,Phase 3,Phase 2,Not Applicable
32 Vaccines Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
33 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Immunoglobulins, Intravenous Phase 4,Phase 3,Phase 2
35 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1,Phase 2,Not Applicable
36 Analgesics Phase 4,Phase 3,Phase 2
37 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
38 beta-Lactams Phase 4
39 Antipyretics Phase 4,Phase 3,Phase 2
40 Lactams Phase 4
41 penicillins Phase 4,Phase 3
42 Gentamicins Phase 4,Phase 3
43 Immunosuppressive Agents Phase 4
44 Antimetabolites Phase 4
45 Heptavalent Pneumococcal Conjugate Vaccine Phase 4,Phase 3,Phase 2
46 Antimetabolites, Antineoplastic Phase 4
47 Antirheumatic Agents Phase 4,Phase 2
48 gamma-Globulins Phase 4,Phase 3,Phase 2
49 Rho(D) Immune Globulin Phase 4,Phase 3,Phase 2
50 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 164)
# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
2 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
3 Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine Unknown status NCT00262015 Phase 4
4 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
5 Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
6 Pneumococcal Vaccination of Crohn Patients Completed NCT01947010 Phase 4
7 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
8 Safety and Efficacy Study of Flebogamma 5% DIF IGIV in Pediatric Subjects Completed NCT00634569 Phase 4
9 Ciprofloxacin for the Prevention of Meningococcal Meningitis Completed NCT02724046 Phase 4 Ciprofloxacin
10 Persistence of Bactericidal Antibodies in Adults Who Received a Booster Dose of Menactra® Approximately 4 Years Earlier Completed NCT02633787 Phase 4
11 Immunogenicity and Safety of Two-Dose Series of Menactra® in Japanese Healthy Adult Subjects Completed NCT02591290 Phase 4
12 A Phase 4, Placebo-Controlled, Randomized Study to Evaluate the Immunogenicity and Safety of HPV and Tdap When Administered With MenACWY in Adolescents Completed NCT01424644 Phase 4
13 Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine Completed NCT00271479 Phase 4
14 A Sourcing Study to Collect Human Blood Samples From Healthy Adults Recruiting NCT03493919 Phase 4
15 Postmarketing Surveillance Study for Use of Menactra® in the Republic of Korea Active, not recruiting NCT02864927 Phase 4
16 Ciprofloxacin for the Prevention of Meningococcal Meningitis 2018 Not yet recruiting NCT03431675 Phase 4 Ciprofloxacin
17 Evaluation of Safety and Immunogenicity of Meningococcal B and Meningococcal ACWY Vaccine in at Risk Population Not yet recruiting NCT03682939 Phase 4
18 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
19 Amikacin Penetration Into the Cerebrospinal Fluid Withdrawn NCT00362245 Phase 4 Systemic and Intra-Thecal Amikacin Therapy
20 Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) Unknown status NCT01581593 Phase 3
21 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
22 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 75 Years of Age in India Completed NCT01547715 Phase 3
23 Immunogenicity and Safety of Meningococcal ACWY Conjugate Vaccine in Healthy Subjects From 2 to 18 Years in Taiwan Completed NCT01410474 Phase 3
24 Safety and Immunogenicity Study of MenC-TT Vaccine (NeisVac-C) in Toddlers Previously Immunized With PCV7 (Prevenar®) Completed NCT00617760 Phase 3
25 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
26 DTaP-IPV/Hib Vaccine Primary & Booster Vaccinations Versus Co-administration of DTaP-IPV and Hib Vaccine in Japanese Infants Completed NCT02274285 Phase 3
27 Open Label, Phase III Study of NABI-IGIV 10% [Immune Globulin Intravenous(Human), 10%] In Subjects With Primary Immune Deficiency Disorders (PIDD) Completed NCT00538915 Phase 3
28 A Study of NewGam, Human Immunoglobulin 10%, in Patients With Primary Immunodeficiency Diseases Completed NCT01012323 Phase 3
29 Immune Globulin Subcutaenous (Human), 20% Completed NCT01412385 Phase 2, Phase 3
30 Extension Study of Subcutaneous Immunoglobulin Human in Patients With Primary Immunodeficiency (PID) Completed NCT00719680 Phase 3
31 Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy Completed NCT00419341 Phase 3
32 Gammagard Liquid and rHuPH20 in PID Completed NCT00814320 Phase 3
33 Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study) Completed NCT01461018 Phase 3
34 A Study of Meningococcal Vaccine, Menactra® in Healthy Subjects in India Completed NCT01086969 Phase 3
35 Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID) Completed NCT00322556 Phase 3 Immunoglobulins Intravenous (Human)
36 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy Completed NCT00542997 Phase 3
37 Follow-up Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (Japan Study) Completed NCT01458171 Phase 3
38 Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy (EU Extension Study) Completed NCT00751621 Phase 3
39 Immunogenicity and Safety of a Meningococcal Conjugate Vaccine Given Concomitantly With Other Vaccines in Toddlers Completed NCT03205371 Phase 3
40 Study of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Administered in Children Aged 2 to 9 Years Completed NCT03077438 Phase 3
41 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Toddlers Completed NCT02955797 Phase 3
42 Immunogenicity and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine in Adults 56 Years and Older Completed NCT02842866 Phase 3
43 Immune Lot Consistency, Immunogenicity, and Safety of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Completed NCT02842853 Phase 3
44 Immunogenicity and Safety of a Booster Dose of an Investigational Quadrivalent Meningococcal Conjugate Vaccine Completed NCT02752906 Phase 3
45 Safety and Blood Donations in Adults Vaccinated With rMenB+OMV NZ. Completed NCT02305446 Phase 3
46 Antibody Persistence, and Safety and Tolerability of a Booster Dose of the Meningococcal B Vaccine After the Completion of the Vaccination Course in Study V72_28 Completed NCT01894919 Phase 3
47 A Global Phase 3 Safety Study of 120 mcg rLP2086 Vaccine in Adolescents and Young Adults Aged 10 to 25 Years Completed NCT01352793 Phase 3
48 Comparison of Two Meningococcal ACWY Conjugate Vaccines Completed NCT01192997 Phase 2, Phase 3
49 Evaluation of Meningococcal Immune Response Among Children Who Previously Received MenACWY Conjugate Vaccine Completed NCT01148017 Phase 3
50 Evaluation of Persistence of Anti-meningococcal Bactericidal Antibodies Among Adolescents Who Previously Received MenACWY Conjugate Vaccine Completed NCT00856297 Phase 3

Search NIH Clinical Center for Bacterial Meningitis

Cochrane evidence based reviews: meningitis, bacterial

Genetic Tests for Bacterial Meningitis

Anatomical Context for Bacterial Meningitis

MalaCards organs/tissues related to Bacterial Meningitis:

41
Brain, Testes, Spinal Cord, Lung, Liver, Bone, Pituitary

Publications for Bacterial Meningitis

Articles related to Bacterial Meningitis:

(show top 50) (show all 1119)
# Title Authors Year
1
Scrub Typhus Meningitis Versus Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396931 )
2018
2
Duplex recombinase polymerase amplification assays incorporating competitive internal controls for bacterial meningitis detection. ( 29378166 )
2018
3
Cerebrospinal Fluid Lactate as a Prognostic Indicator in Postneurosurgical Bacterial Meningitis and Use of Intrathecal Colistin. ( 29743769 )
2018
4
Delayed Cerebral Injury in Adults With Bacterial Meningitis: A Novel Complication of Adjunctive Steroids? ( 29746358 )
2018
5
A world without bacterial meningitis: how genomic epidemiology can inform vaccination strategy. ( 29636909 )
2018
6
Adult-Onset Recurrent Bacterial Meningitis: Immunological Red Herrings. ( 29401276 )
2018
7
Using Predictive Model for Screening Bacterial Meningitis in National Surveillance System in Iran. ( 29968622 )
2018
8
Cerebrospinal fluid monocytes in bacterial meningitis, viral meningitis, and neuroborreliosis. ( 29628177 )
2018
9
Detection of Bacterial Meningitis Pathogens by PCR-Mass Spectrometry in Cerebrospinal Fluid. ( 29945321 )
2018
10
<i>Burkholderia multivorans:</i> A rare yet emerging cause of bacterial meningitis. ( 29619322 )
2018
11
Correction to: Meta-analysis of adjunctive dexamethasone to improve clinical outcome of bacterial meningitis in children. ( 29322336 )
2018
12
Comparison of Scrub Typhus Meningitis with Acute Bacterial Meningitis and Tuberculous Meningitis. ( 29396933 )
2018
13
Repeated Audiometry After Bacterial Meningitis: Consequences for Future Management. ( 29659414 )
2018
14
Osmotic therapies added to antibiotics for acute bacterial meningitis. ( 29405037 )
2018
15
Elevations of novel cytokines in bacterial meningitis in infants. ( 29394248 )
2018
16
Mathematical Modelling of Bacterial Meningitis Transmission Dynamics with Control Measures. ( 29780431 )
2018
17
Cerebrospinal fluid lactate as a marker to differentiate between community-acquired acute bacterial meningitis and aseptic meningitis/encephalitis in adults: a Danish prospective observational cohort study. ( 29490540 )
2018
18
Anaerobic bacterial meningitis in adults. ( 29396061 )
2018
19
Bacterial meningitis in neonates and infants - the sonographic picture. ( 29844943 )
2018
20
Variation in coagulation and fibrinolysis genes evaluated for their contribution to cerebrovascular complications in adults with bacterial meningitis in the Netherlands. ( 29746949 )
2018
21
Evaluation of an Internally Controlled Multiplex Tth Endonuclease Cleavage Loop-Meditated Isothermal Amplification (TEC-LAMP) Assay for the Detection of Bacterial Meningitis Pathogens. ( 29425124 )
2018
22
The clinical characteristics of adult bacterial meningitis caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas species: A clinical comparison with Ps. aeruginosa meningitis. ( 29310816 )
2018
23
Ectopic Prolactinoma Presenting as Bacterial Meningitis: A Diagnostic Conundrum. ( 29378345 )
2018
24
Vitamin D was not associated with survival or cerebrospinal fluid cathelicidin levels in children with bacterial meningitis. ( 29751358 )
2018
25
Biot's breathing associated with acute bacterial meningitis in a child. ( 29960974 )
2018
26
Diagnostic scoring system for tuberculous meningitis among adult patients with non-suppurative and non-bacterial meningitis. ( 29705393 )
2018
27
Burden of bacterial meningitis in India: Preliminary data from a hospital based sentinel surveillance network. ( 29768458 )
2018
28
Genes and their single nucleotide polymorphism involved in innate immune response in central nervous system in bacterial meningitis: review of literature data. ( 29754263 )
2018
29
Bacterial Meningitis as a Cause of Death in Lung Transplant Donors: Early Outcomes in Recipients. ( 29862567 )
2018
30
Global etiology of bacterial meningitis: A systematic review and meta-analysis. ( 29889859 )
2018
31
Clinical Characteristics and Risk Factors for Poor Outcome in Infants Less Than 90 Days of Age with Bacterial Meningitis in the United Kingdom and Ireland. ( 29384979 )
2018
32
Temporal trends in paediatric bacterial meningitis in a tropical Australian region: 1992-2014. ( 29754466 )
2018
33
A Case of Recurrent Bacterial Meningitis Due to Retained 54-Year-Old Ureterodural Anastomosis. ( 30151398 )
2018
34
Accuracy of heparin binding protein: as a new marker in prediction of acute bacterial meningitis. ( 30166267 )
2018
35
The attitudes, behaviors, and knowledge of healthcare professionals towards the diagnosis, treatment, and prevention of bacterial meningitis in Turkey. ( 30192703 )
2018
36
Utility of Clinical and Laboratory Decision Rules in Identifying Bacterial Meningitis Among Children With suspicion of Central Nervous System Infections in a Malaria-Endemic Area, Mbarara Uganda. ( 30199480 )
2018
37
Lack of chemokine (C-C motif) ligand 3 leads to decreased survival and reduced immune response after bacterial meningitis. ( 30199766 )
2018
38
Lung transplantation from brain-dead donors with bacterial meningitis: Proper donor evaluation for successful lung transplantation. ( 30251276 )
2018
39
Compartmental models for seasonal hyperendemic bacterial meningitis in the African meningitis belt. ( 30264686 )
2018
40
Acute Bacterial Meningitis. ( 30273239 )
2018
41
CSF leukocyte, polykaryocyte, protein and glucose: Their cut-offs of judging whether post-neurosurgical bacterial meningitis has been cured. ( 30273842 )
2018
42
A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. ( 30299497 )
2018
43
Intra-arterial Injection of Fasudil Hydrochloride for Cerebral Vasospasm Secondary to Bacterial Meningitis. ( 30327749 )
2018
44
Patterns of cerebral tissue oxygen tension and cytoplasmic redox state in bacterial meningitis. ( 30328110 )
2018
45
Pediatric bacterial meningitis: an update on early identification and management. ( 30358380 )
2018
46
Anterior spinal cord syndrome as a rare complication of acute bacterial meningitis in an adult. ( 30361450 )
2018
47
Acute Community-Acquired Bacterial Meningitis. ( 30366556 )
2018
48
Diagnostic Value of Procalcitonin for Bacterial Meningitis in Children: A Comparison Analysis Between Serum and Cerebrospinal Fluid Procalcitonin Levels. ( 30371098 )
2018
49
Clinical Features of and Risk Factors for Hydrocephalus in Childhood Bacterial Meningitis. ( 30373442 )
2018
50
Calculated decisions: bacterial meningitis score for children ( 30383346 )
2018

Variations for Bacterial Meningitis

Expression for Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for Bacterial Meningitis

Pathways related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CFP CRP CXCL8 IL10 IL1B IL6
2
Show member pathways
13.4 CXCL8 IL10 IL1B IL6 TLR2 TLR9
3
Show member pathways
13.06 CXCL8 IL1B IL6 MMP9 TLR2 TNF
4
Show member pathways
13.04 CXCL8 IL10 IL1B IL6 TLR2 TLR9
5
Show member pathways
12.86 CXCL8 IL10 IL1B IL6 TNF
6
Show member pathways
12.82 CFP CXCL8 IL1B IL6 TLR2 TLR9
7
Show member pathways
12.77 CXCL8 IL1B IL6 S100B TNF
8
Show member pathways
12.72 IL1B IL6 TLR2 TLR9 TNF
9
Show member pathways
12.62 IL10 IL1B IL6 TLR2 TNF
10 12.59 IL10 IL1B TLR2 TLR9 TNF
11
Show member pathways
12.57 IL10 IL1B IL6 TNF
12
Show member pathways
12.42 IL10 IL1B IL6 TNF
13
Show member pathways
12.38 ALB CRP IL1B IL6 TNF
14
Show member pathways
12.38 CXCL8 IL1B IL6 MMP9 TLR2 TNF
15
Show member pathways
12.31 CXCL8 IL1B IL6 TNF
16
Show member pathways
12.31 CXCL8 IL6 TLR2 TLR9 TNF
17
Show member pathways
12.29 CXCL8 IL10 IL1B IL6 TNF
18
Show member pathways
12.28 IL10 IL1B TLR2 TNF
19
Show member pathways
12.27 CXCL8 IL1B IL6 TLR2 TNF
20 12.27 IL10 IL1B IL6 TLR2 TLR9 TNF
21
Show member pathways
12.26 IL10 IL1B IL6 TLR9 TNF
22
Show member pathways
12.25 CXCL8 IL1B MMP8 MMP9 TLR2 TLR9
23 12.23 IL6 MMP9 TLR2 TLR9 TNF
24 12.22 CXCL8 IL10 IL1B IL6 TNF
25
Show member pathways
12.17 CXCL8 IL1B IL6 TLR2 TLR9 TNF
26
Show member pathways
12.1 IL1B IL6 MMP9 TLR2 TNF
27 12.08 CXCL8 IL1B IL6 MMP9 TNF
28
Show member pathways
12.06 IL1B PIK3C2A TLR2 TLR9
29 12 IL1B IL6 MMP9 TNF
30 11.97 IL10 IL6 TNF
31
Show member pathways
11.96 IL10 IL1B IL6 TLR2 TLR9 TNF
32 11.95 CXCL8 IL1B IL6 TNF
33 11.93 CXCL8 IL1B IL6
34 11.91 CXCL8 IL1B IL6 TLR2 TNF
35
Show member pathways
11.9 MMP8 MMP9 TNF
36 11.89 IL1B IL6 TNF
37 11.88 CXCL8 IL1B TNF
38 11.83 CXCL8 IL1B IL6
39 11.83 CXCL8 IL10 IL1B IL6 TNF
40 11.79 IL10 IL1B TNF
41 11.79 IL10 IL1B IL6 TLR9 TNF
42 11.79 CXCL8 IL10 IL1B IL6 MMP9 TNF
43 11.76 IL10 IL1B IL6 MMP9 TNF
44 11.7 CXCL8 IL6 MMP9
45 11.65 CXCL8 IL1B IL6 MMP9 TNF
46
Show member pathways
11.63 CXCL8 IL1B IL6 MMP9 TNF
47 11.62 CXCL8 IL10 IL1B IL6 TLR2 TNF
48 11.55 IL6 MMP9 TNF
49 11.55 IL1B TLR2 TNF
50 11.54 CXCL8 IL1B IL6 TLR2 TNF

GO Terms for Bacterial Meningitis

Cellular components related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 ALB CFP CRP CXCL8 IL10 IL1B
2 extracellular space GO:0005615 9.44 ALB CFP CKB CRP CXCL8 IL10
3 tertiary granule lumen GO:1904724 9.33 CFP MMP8 MMP9

Biological processes related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.97 CXCL8 IL10 IL1B IL6 MMP9 TNF
2 immune response GO:0006955 9.97 CFP CXCL8 IL10 IL1B IL6 TLR2
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.96 IL1B S100B TLR9 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.93 CXCL8 IL10 IL1B IL6 TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 IL1B IL6 TLR2 TLR9 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 IL10 IL1B IL6 TNF
7 positive regulation of inflammatory response GO:0050729 9.88 TLR2 TLR9 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.88 CRP IL6 TLR2 TNF
9 positive regulation of JNK cascade GO:0046330 9.87 IL1B MMP8 TLR9 TNF
10 positive regulation of tumor necrosis factor production GO:0032760 9.85 MMP8 TLR2 TLR9
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.83 IL10 MMP9 TNF
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B MMP8 TNF
13 positive regulation of JUN kinase activity GO:0043507 9.8 IL1B TLR9 TNF
14 response to glucocorticoid GO:0051384 9.8 IL10 IL1B IL6 S100B TNF
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.78 IL1B TLR2 TNF
16 negative regulation of interleukin-6 production GO:0032715 9.77 IL10 TLR9 TNF
17 negative regulation of neurogenesis GO:0050768 9.76 IL1B IL6 TNF
18 positive regulation of interleukin-8 production GO:0032757 9.76 IL1B TLR2 TLR9 TNF
19 inflammatory response GO:0006954 9.76 CRP CXCL8 IL10 IL1B IL6 TLR2
20 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B IL6 TNF
21 positive regulation of chemokine production GO:0032722 9.73 IL6 TLR2 TLR9 TNF
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
23 negative regulation of growth of symbiont in host GO:0044130 9.72 IL10 TNF
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL10 IL1B TNF
25 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.72 IL1B MMP8 TLR2 TLR9 TNF
26 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR2 TLR9
27 regulation of cytokine secretion GO:0050707 9.71 TLR2 TLR9
28 I-kappaB phosphorylation GO:0007252 9.71 TLR2 TLR9
29 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL1B TLR9
30 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.7 TLR9 TNF
31 endothelial cell apoptotic process GO:0072577 9.69 IL10 TNF
32 positive regulation of chemokine biosynthetic process GO:0045080 9.69 IL1B TNF
33 negative regulation of interleukin-8 production GO:0032717 9.69 IL10 TLR9
34 negative regulation of lipid storage GO:0010888 9.69 CRP IL6 TNF
35 regulation of establishment of endothelial barrier GO:1903140 9.68 IL1B TNF
36 negative regulation of cytokine secretion involved in immune response GO:0002740 9.68 IL10 TNF
37 positive regulation of fever generation GO:0031622 9.67 IL1B TNF
38 positive regulation of interleukin-18 production GO:0032741 9.67 TLR2 TLR9
39 regulation of neuroinflammatory response GO:0150077 9.66 MMP8 MMP9
40 tumor necrosis factor production GO:0032640 9.66 TLR2 TLR9
41 chronic inflammatory response to antigenic stimulus GO:0002439 9.65 IL1B TNF
42 positive regulation of toll-like receptor signaling pathway GO:0034123 9.64 TLR2 TLR9
43 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
45 receptor biosynthetic process GO:0032800 9.62 IL10 TNF
46 regulation of microglial cell activation GO:1903978 9.61 MMP8 TNF
47 response to molecule of bacterial origin GO:0002237 9.56 CXCL8 IL10 TLR2 TLR9
48 positive regulation of neuroinflammatory response GO:0150078 9.26 IL1B IL6 MMP8 TNF
49 positive regulation of interleukin-6 production GO:0032755 9.1 IL1B IL6 MMP8 TLR2 TLR9 TNF
50 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 IL10 IL1B IL6 TLR2 TLR9 TNF

Molecular functions related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 ALB CRP MMP9 S100B TLR2 TNF
2 interleukin-1 receptor binding GO:0005149 9.26 IL1B TLR9
3 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL1B IL6 TNF
4 signaling pattern recognition receptor activity GO:0008329 8.96 TLR2 TLR9

Sources for Bacterial Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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