MCID: BCT007
MIFTS: 55

Bacterial Meningitis

Categories: Ear diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Bacterial Meningitis

MalaCards integrated aliases for Bacterial Meningitis:

Name: Bacterial Meningitis 12 73 20 3 15 17
Meningitis, Bacterial 20 44 70
Meningitis Bacterial 54

Classifications:



External Ids:

Disease Ontology 12 DOID:9470
ICD9CM 34 320
MeSH 44 D016920
NCIt 50 C118297
SNOMED-CT 67 267680008
ICD10 32 G00 G00.9
UMLS 70 C0085437

Summaries for Bacterial Meningitis

CDC : 3 Bacterial meningitis is very serious and can be deadly. Death can occur in as little as a few hours. Most people recover from meningitis. However, permanent disabilities (such as brain damage, hearing loss, and learning disabilities) can result from the infection. Several types of bacteria can cause meningitis. Leading causes in the United States include Streptococcus pneumoniae Group B Streptococcus Neisseria meningitidis Haemophilus influenzae Listeria monocytogenes These bacteria can also be associated with another serious illness, sepsis. Sepsis is the body’s extreme response to infection. Without timely treatment, sepsis can quickly lead to tissue damage, organ failure, and death.

MalaCards based summary : Bacterial Meningitis, also known as meningitis, bacterial, is related to haemophilus meningitis and haemophilus influenzae. An important gene associated with Bacterial Meningitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Cefotaxime and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, pituitary and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A meningitis that has material basis in a bacterial infection.

Wikipedia : 73 Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord,... more...

Related Diseases for Bacterial Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Bacterial Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1001)
# Related Disease Score Top Affiliating Genes
1 haemophilus meningitis 32.6 TNF IL1B CRP
2 haemophilus influenzae 32.4 TNF TLR2 CXCL8
3 aseptic meningitis 32.2 TNF IL1B IL10 CXCL8 CRP
4 viral meningitis 32.1 IL6 CXCL8 CRP
5 meningococcal meningitis 32.1 TLR9 TLR4 TLR2 MBL2 CFP
6 tuberculous meningitis 31.4 TNF TLR2 MMP9 CXCL8
7 cerebral palsy 31.3 TNF TLR4 MMP8 MBL2 IL6 IL1B
8 intracranial hypertension 31.2 TNF IL1B AQP4
9 neisseria meningitidis infection 31.2 TLR4 TLR2 MBL2 CFP
10 cerebritis 31.0 TNF IL1B CRP AQP4
11 pleural empyema 30.9 IL6 CRP ALB
12 arachnoiditis 30.8 TNF IL1B CRP AQP4
13 vasculitis 30.7 TNF MBL2 IL6 IL17A CRP
14 cranial nerve palsy 30.7 CRP AQP4 ALB
15 meningoencephalitis 30.6 TNF IL6 IL1B IL10 CRP ALB
16 epidemic typhus 30.6 TNF IL10 CRP
17 epidural abscess 30.6 CRP ALB
18 toxic shock syndrome 30.6 TNF TLR4 TLR2 IL6 IL1B IL10
19 brain edema 30.5 MMP9 IL6 IL1B CRP AQP4 ALB
20 encephalitis 30.5 TNF TLR2 IL6 IL1B IL10 CCL4
21 herpes zoster 30.5 TNF TLR2 IL10
22 purpura 30.5 TNF IL6 IL10 CRP
23 septic arthritis 30.5 TNF TLR9 TLR4 TLR2 CXCL8 CRP
24 meningitis 30.5 TNF TLR9 TLR4 TLR2 MMP9 MBL2
25 traumatic brain injury 30.5 IL6 IL1B AQP4
26 meningococcemia 30.4 MBL2 IL1B CFP
27 suppurative otitis media 30.4 TLR4 TLR2 IL1B CRP
28 guillain-barre syndrome 30.4 TNF IL17A ALB
29 urinary tract infection 30.4 TLR4 CRP
30 viral encephalitis 30.4 TNF IL6 IL1B IL10 CXCL8
31 encephalomalacia 30.4 TNF IL6 IL1B CXCL8 CRP
32 listeriosis 30.3 TNF TLR2 MBL2 IL6 IL1B IL10
33 thrombocytosis 30.3 IL6 IL1B CRP ALB
34 measles 30.3 TNF TLR9 TLR4 TLR2 IL6 IL1B
35 varicose veins 30.3 TNF MMP9 IL6 CXCL8
36 facial paralysis 30.3 TNF CRP ALB
37 brain injury 30.3 IL6 IL1B AQP4 ALB
38 chickenpox 30.3 TNF IL6 IL10 CRP ALB
39 pain agnosia 30.3 TNF IL6 IL1B ALB
40 disseminated intravascular coagulation 30.2 TNF PIK3C2A IL6 IL10 CRP
41 rubella 30.2 TNF TLR4 IL6 IL1B IL10
42 papilledema 30.2 CRP AQP4 ALB
43 myelitis 30.2 TNF MMP9 IL6 IL17A IL10 CXCL8
44 chronic meningitis 30.2 MMP9 IL1B CRP ALB
45 scrub typhus 30.1 TNF TLR4 TLR2 IL1B IL17A IL10
46 pharyngitis 30.1 TNF IL6 IL1B CXCL8 CRP
47 exanthem 30.1 TNF PIK3C2A IL6 IL1B IL10 CXCL8
48 infective endocarditis 30.1 TNF TLR2 IL6 IL17A CRP CCL4
49 intussusception 30.1 IL6 CRP ALB
50 protein-energy malnutrition 30.1 TNF IL6 ALB

Comorbidity relations with Bacterial Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Bacterial Meningitis:



Diseases related to Bacterial Meningitis

Symptoms & Phenotypes for Bacterial Meningitis

MGI Mouse Phenotypes related to Bacterial Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 ALB AQP4 CFP CRP IL10 IL1B
2 homeostasis/metabolism MP:0005376 10.27 ALB AQP4 CFP CRP IL10 IL17A
3 immune system MP:0005387 10.22 ALB AQP4 CFP CRP IL10 IL17A
4 hematopoietic system MP:0005397 10.18 AQP4 IL10 IL17A IL1B IL6 MBL2
5 digestive/alimentary MP:0005381 10.13 ALB AQP4 IL10 IL17A IL6 MMP9
6 neoplasm MP:0002006 9.91 ALB IL10 IL1B IL6 MMP8 MMP9
7 renal/urinary system MP:0005367 9.85 ALB AQP4 IL17A IL6 MBL2 MMP9
8 respiratory system MP:0005388 9.56 AQP4 IL10 IL17A IL6 MMP9 TLR2
9 skeleton MP:0005390 9.32 CFP IL10 IL17A IL1B IL6 MBL2

Drugs & Therapeutics for Bacterial Meningitis

Drugs for Bacterial Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 120)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
2
Acetaminophen Approved Phase 4 103-90-2 1983
3 Gentamicins Phase 4
4 penicillins Phase 4
5 Analgesics, Non-Narcotic Phase 4
6 Analgesics Phase 4
7 beta-Lactams Phase 4
8 Antipyretics Phase 4
9 Lactams Phase 4
10 Neuromuscular Blocking Agents Phase 4
11
Lactitol Approved, Investigational Phase 3 585-86-4 157355
12
Glycerol Approved, Investigational Phase 3 56-81-5 753
13 Vaccines Phase 3
14 Protective Agents Phase 3
15 Immunologic Factors Phase 3
16 Heptavalent Pneumococcal Conjugate Vaccine Phase 3
17
Daptomycin Approved, Investigational Phase 1 103060-53-3 16129629
18
Ciprofloxacin Approved, Investigational Early Phase 1 85721-33-1 2764
19
Dopamine Approved 51-61-6, 62-31-7 681
20
Cefepime Approved, Investigational 88040-23-7 5479537
21
Methylprednisolone Approved, Vet_approved 83-43-2 6741
22
Molindone Approved 7416-34-4 23897
23
Haloperidol Approved 52-86-8 3559
24
Diphenhydramine Approved, Investigational 147-24-0, 58-73-1 3100
25
Tazobactam Approved 89786-04-9 123630
26
Cidofovir Approved 113852-37-2 60613
27
Aminocaproic acid Approved, Investigational 60-32-2 564
28
Oxycodone Approved, Illicit, Investigational 76-42-6 5284603
29
Tranexamic Acid Approved 1197-18-8 5526
30
Alfentanil Approved, Illicit 71195-58-9 51263
31
Prednisolone Approved, Vet_approved 50-24-8 5755
32
Prednisolone acetate Approved, Vet_approved 52-21-1
33
Labetalol Approved 36894-69-6 3869
34
Pentobarbital Approved, Investigational, Vet_approved 76-74-4 4737
35
Sevelamer Approved 52757-95-6
36
Rocuronium Approved 119302-91-9, 143558-00-3 441290
37
Methylprednisolone hemisuccinate Approved 2921-57-5
38
Clozapine Approved 5786-21-0 2818
39
Nafcillin Approved, Investigational 147-52-4, 985-16-0 8982
40
Bosentan Approved, Investigational 147536-97-8 104865
41
Zolpidem Approved 82626-48-0 5732
42
Prednisolone phosphate Approved, Vet_approved 302-25-0
43
Promethazine Approved, Investigational 60-87-7 4927
44
Nifedipine Approved 21829-25-4 4485
45
Ziprasidone Approved 146939-27-7 60854
46
Piperacillin Approved 66258-76-2 43672
47
Warfarin Approved 81-81-2 6691 54678486
48
Spironolactone Approved 1952-01-7, 52-01-7 5833
49
Tobramycin Approved, Investigational 32986-56-4 5496 36294
50
Fosfomycin Approved 23155-02-4 446987

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 An Open Randomised Trial of Ceftriaxone v Penicillin and Gentamicin in Infant Severe Sepsis and Bacterial Meningitis in Malawi Completed NCT01247909 Phase 4 Ceftriaxone v penicillin and gentamicin
2 Slow Initial β-lactam Infusion With High-dose Paracetamol to Improve the Outcomes of Childhood Bacterial Meningitis, Especially of Pneumococcal Meningitis, in Angola. Completed NCT01540838 Phase 4 Infusion with paracetamol;Bolus without paracetamol
3 Mild Induced Hypothermia to Treat Severe Community Acquired Meningitis in Adults Admitted to Intensive Care Unit Terminated NCT00774631 Phase 4
4 Amikacin Penetration Into the Cerebrospinal Fluid: Pharmacokinetic/Pharmacodynamic Analysis in Adults With Hospital Acquired Gram-negative Meningitis Associated With Intracranial Pressure Monitoring and Draining Devices Withdrawn NCT00362245 Phase 4 Systemic and Intra-Thecal Amikacin Therapy
5 A Phase 3, Multicenter, Open-label Study to Evaluate Immunogenicity and Safety of Novartis Meningococcal ACWY Conjugate Vaccine (MenACWY-CRM) in Healthy Subjects From 2 to 18 Years in Taiwan Completed NCT01410474 Phase 3
6 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis - A Prospective, Randomized, and Double-Blind Clinical Study Using a Two-by-Two Factorial Design Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
7 A Phase 3, Multi-center, Open-label Study to Evaluate Immunogenicity and Safety of Novartis Meningococcal ACWY Conjugate Vaccine (MenACWY-CRM) in Healthy Subjects From 2 to 75 Years of Age in India. Completed NCT01547715 Phase 3
8 Open-label, Randomized, 3-arm, Phase 3B Clinical Study to Investigate the Safety and Immunogenicity of a Concomitant Administration of Group C Meningococcal Polysaccharide-Tetanus Toxoid Conjugate (MenC-TT) Vaccine and 7-valent Pneumococcal CRM197-conjugate Vaccine (PCV7) in Toddlers Previously Immunized During Infancy With PCV7 Completed NCT00617760 Phase 3
9 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
10 Immunogenicity and Safety of the DTaP-IPV/Hib Vaccine SP0204) Given as Three-dose Primary and One-dose Booster Vaccinations Versus Co-administration of DTaP-IPV Vaccine (DD-687) and Hib Vaccine (DF-098) in Infants in Japan Completed NCT02274285 Phase 3
11 Phase 3 Study of BK1310 Compared With ActHIB® and Tetrabik in Healthy Infants: A Randomized, Assessor-blind, Active-controlled Completed NCT03891758 Phase 3
12 Evaluation of Cerebrospinal Fluid Concentration of Daptomycin (Cubicin¬) in Pediatric Patients With Gram-positive Bacterial Meningitis, Concurrently Receiving Standard Antimicrobial Therapy Terminated NCT01522105 Phase 1 Daptomycin
13 Surveillance of Hospitalised Pneumonia and Bacterial Meningitis in Tône District, Togo, 2010-2013 Unknown status NCT01747369
14 Association of Serum 25-hydroxyvitamin D Levels and Outcomes in Children With Bacterial Meningitis Unknown status NCT02467309
15 Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients. Unknown status NCT03252028
16 Bacterial Meningitis in Adults: Analysis of the Determinants of Mortality and Neurosensory Sequelae Completed NCT01730690
17 Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis Completed NCT03595761
18 Challenge of the Nasopharynx With Neisseria Lactamica Expressing the Meningococcal Protein Neisseria Adhesin A (NadA) Completed NCT03630250 Early Phase 1
19 Lactamica 7: Defining the Immune Response to Nasopharyngeal Colonisation by the Commensal Neisseria Lactamica Completed NCT03633474 Early Phase 1
20 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Completed NCT01431326 The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
21 Neisseria Meningitidis Burden of Disease Completed NCT01730391
22 Monitoring Pneumococcal Conjugate Vaccine Introduction in Cambodia: A Study of Streptococcus Pneumoniae Colonisation, Pneumonia and Invasive Disease in Cambodian Children Completed NCT03331952
23 A Multicenter Prospective Cohort Study on Neonatal Bacterial Meningitis Recruiting NCT03499652
24 Application of Next Generation Sequencing Technique in Pediatric Bacterial Meningitis Recruiting NCT03953638
25 A Human Controlled Infection Study to Assess Safety, Colonisation and Immunogenicity Following Nasal Inoculation With Reconstituted Lyophilised Wild Type Neisseria Lactamica Recruiting NCT04135053
26 Danish Study Group of Infections of the Brain: A Nationwide Prospective Observational Cohort Study of All Central Nervous System Infections in Adults at Departments of Infectious Diseases in Denmark Recruiting NCT03418441
27 A European, Multicentre, Non-comparative, Non-interventional, Prospective Clinical Registry to Evaluate the Clinical Outcome and Safety of the Treatment of Severely Infected Patients With Fosfomycin i.v. Recruiting NCT02979951
28 Integrating the Diagnosis and Management of HIV-associated Central Nervous System (CNS) Infections Into Routine Health Services in Low and Middle Income Countries (LMICs) Recruiting NCT03226379
29 Febrile Infants - Diagnostic Assessment and Outcome Active, not recruiting NCT04196192
30 Population Pharmacokinetics of Commonly Used Antimicrobial Agents in Children of Bacterial Meningitis With Augmented Renal Clearance Not yet recruiting NCT04771884 meropenem vancomycin ceftazidime ceftriaxone ceftizoxime linezolid
31 Systematic Search for Primary Immunodeficiency in Adults With Unexplained Recurrent and/or Severe Infections With Encapsulated Bacteria Terminated NCT02972281

Search NIH Clinical Center for Bacterial Meningitis

Cochrane evidence based reviews: meningitis, bacterial

Genetic Tests for Bacterial Meningitis

Anatomical Context for Bacterial Meningitis

MalaCards organs/tissues related to Bacterial Meningitis:

40
Spinal Cord, Pituitary, Bone, Endothelial, Brain, Heart, Neutrophil

Publications for Bacterial Meningitis

Articles related to Bacterial Meningitis:

(show top 50) (show all 7489)
# Title Authors PMID Year
1
Adenosine deaminase and tuberculous meningitis--a systematic review with meta-analysis. 54 61
20001225 2010
2
Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis. 54 61
19814625 2009
3
[Laboratory diagnosis of bacterial meningitis: usefulness of various tests for the determination of the etiological agent]. 54 61
19398286 2009
4
Markers that predict serious bacterial infection in infants under 3 months of age presenting with fever of unknown origin. 54 61
19158133 2009
5
Bacterial meningitis: rapid diagnosis and microbial profile: a multicentered study. 54 61
19301695 2008
6
C-reactive protein as an indicator of aqueductal gliosis and hydrocephaly in neonatal meningitis. 54 61
18581011 2008
7
Rarity of bacterial and viral meningitis in areas of Western Greece with fewer than 2,000 inhabitants. 61 54
18219135 2008
8
TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia. 61 54
17947688 2007
9
Fibronectin is elevated in the cerebrospinal fluid of patients suffering from bacterial meningitis and enhances inflammation caused by bacterial products in primary mouse microglial cell cultures. 61 54
17561936 2007
10
beta-Glucuronidase activity in cerebrospinal fluid pleocytosis due to urinary tract infection. 54 61
17577341 2007
11
[Changes and clinical significance of Toll-like receptor 2 and 4 expression in neonatal infections]. 61 54
17456342 2007
12
Lipopolysaccharide binding protein is a potential marker for invasive bacterial infections in children. 54 61
17259880 2007
13
Properdin deficiency in a boy with fulminant meningococcal septic shock. 54 61
17062484 2006
14
Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in adults. 61 54
17333738 2006
15
Cytokines and adhesion molecules expression in the brain in human cerebral malaria. 61 54
16705810 2005
16
[Concentration of proinflammatory cytokines (TNF-alpha, IL-8) in the cerebrospinal fluid and the course of bacterial meningitis]. 61 54
15230146 2004
17
Chemotactic activity of CXCL5 in cerebrospinal fluid of children with bacterial meningitis. 61 54
14644041 2003
18
Beta-glucuronidase in the diagnosis of bacterial meningitis and response to treatment. 61 54
14696846 2003
19
New and old diagnostic markers of meningitis in cerebrospinal fluid (CSF). 61 54
12909299 2003
20
[Acute meningitidis, acute phase proteins and procalcitonin]. 54 61
12702467 2003
21
Interleukin-8 levels in children with bacterial, tuberculous and aseptic meningitis. 54 61
12003295 2002
22
Interleukin-1beta and tumor necrosis factor-alpha in cerebrospinal fluid of children with bacterial meningitis. 54 61
11508533 2001
23
Significance of cerebrospinal fluid adenosine deaminase isoenzymes in tuberculous (TB) meningitis. 54 61
11574950 2001
24
Levels of three inflammation markers, C-reactive protein, serum amyloid A protein and procalcitonin, in the serum and cerebrospinal fluid of patients with meningitis. 54 61
11763415 2001
25
Serum C-reactive protein in the differential diagnosis of childhood meningitis. 54 61
11059546 2000
26
Systemic neutralization of interleukin-8 markedly reduces neutrophilic pleocytosis during experimental lipopolysaccharide-induced meningitis in rabbits. 61 54
10992482 2000
27
Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae. 61 54
10913401 2000
28
Value of cerebrospinal fluid leukocyte aggregation in distinguishing the causes of meningitis in children. 54 61
10643853 2000
29
Cerebrospinal fluid tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and interleukin-8 as diagnostic markers of cerebrospinal fluid infection in neurosurgical patients. 61 54
10667525 2000
30
C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. 54 61
10356141 1999
31
[Quantitative levels of serum amyloid A protein and other proteins in cerebrospinal fluid and serum of patients with meningitis]. 54 61
9800479 1998
32
C-reactive protein and bacterial meningitis: a meta-analysis. 61 54
9819187 1998
33
Chemokines and chemotaxis of leukocytes in infectious meningitis. 61 54
9626995 1998
34
Etiology of central nervous system infections in the Philippines and the role of serum C-reactive protein in excluding acute bacterial meningitis. 61 54
10225986 1998
35
The production of macrophage inflammatory protein-1alpha in the cerebrospinal fluid at the initial stage of meningitis in children. 54 61
9396559 1997
36
Levels of interleukin-6, CRP and alpha 2 macroglobulin in cerebrospinal fluid (CSF) and serum as indicator of blood-CSF barrier damage. 54 61
9350334 1997
37
[The role of carbapenems in the treatment of nosocomial infection]. 54 61
9410075 1997
38
The pattern of interleukin-1beta (IL-1beta) and its modulating agents IL-1 receptor antagonist and IL-1 soluble receptor type II in acute meningococcal infections. 61 54
9242541 1997
39
[Bacterial meningitis and CSF cytokines]. 54 61
15034315 1997
40
TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis. 54 61
9218605 1997
41
Tumor necrosis factor-alpha and interleukin-1 beta levels in children with bacterial, tuberculous and aseptic meningitis. 54 61
9223915 1997
42
Increased activity of lysosomal acid hydrolases in the cell-free cerebrospinal fluid of bacterial meningitis. 61 54
9029645 1997
43
Chemokines in the cerebrospinal fluid of patients with meningitis. 54 61
8764560 1996
44
Inflammatory cytokines in CSF in bacterial meningitis: association with altered blood flow velocities in basal cerebral arteries. 61 54
8676162 1996
45
Cerebrospinal fluid adenosine deaminase activity for the diagnosis of tuberculous meningitis in children. 54 61
8699576 1996
46
C-reactive protein as an indicator of complications in bacterial meningitis. 54 61
8979584 1996
47
Diffusion of 3-quaternary ammonium cephem antibiotics into cerebrospinal fluid of patients with bacterial meningitis. 61 54
8738850 1996
48
Cerebrospinal fluid interleukin-6, interleukin-8, and tumor necrosis factor-alpha in children with central nervous system infections. 61 54
8936005 1996
49
[C-reactive protein (CRP) and its significance in purulent meningitis]. 54 61
8584095 1995
50
Adenosine deaminase levels in cerebrospinal fluid in tuberculosis and bacterial meningitis. 61 54
7579324 1995

Variations for Bacterial Meningitis

Expression for Bacterial Meningitis

Search GEO for disease gene expression data for Bacterial Meningitis.

Pathways for Bacterial Meningitis

Pathways related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 TNF TLR9 TLR4 TLR2 MMP9 MMP8
2
Show member pathways
13.74 TNF TLR4 IL6 IL1B IL17A IL10
3
Show member pathways
13.52 TNF TLR9 TLR4 TLR2 IL6 IL1B
4
Show member pathways
13.47 TNF MMP9 IL6 IL1B IL17A IL10
5
Show member pathways
13.39 TNF IL6 IL1B IL17A IL10 CXCL8
6
Show member pathways
13.25 TNF TLR9 TLR4 TLR2 MMP9 MBL2
7
Show member pathways
13.08 TNF TLR4 TLR2 IL6 IL1B CXCL8
8
Show member pathways
12.95 TNF IL6 IL1B IL17A IL10 CXCL8
9
Show member pathways
12.95 TNF TLR9 TLR4 TLR2 IL6 IL1B
10 12.9 TNF TLR9 TLR2 IL6 IL1B CFP
11
Show member pathways
12.89 TNF TLR9 TLR4 TLR2 PIK3C2A IL1B
12
Show member pathways
12.87 TNF TLR9 TLR4 TLR2 PIK3C2A IL6
13
Show member pathways
12.81 TNF TLR9 TLR4 TLR2 IL6 IL1B
14
Show member pathways
12.74 TNF TLR4 TLR2 IL6 IL1B IL17A
15
Show member pathways
12.74 TNF TLR9 TLR4 TLR2 IL6 IL1B
16
Show member pathways
12.71 TNF IL6 IL1B IL17A IL10 CXCL1
17 12.69 TNF TLR9 TLR2 IL1B IL17A IL10
18
Show member pathways
12.67 TNF TLR9 TLR4 TLR2 IL1B
19
Show member pathways
12.56 TNF TLR9 TLR4 TLR2 IL6 IL1B
20
Show member pathways
12.49 TNF IL6 IL10 CXCL8 CXCL1 CCL4
21
Show member pathways
12.45 TNF IL6 IL1B CRP ALB
22
Show member pathways
12.45 TNF TLR2 MMP9 IL6 IL1B IL17A
23
Show member pathways
12.43 TNF TLR9 TLR4 TLR2 IL6 CXCL8
24
Show member pathways
12.42 TNF TLR4 IL6 IL1B CXCL8
25
Show member pathways
12.42 TNF TLR4 TLR2 IL1B IL10 CR1
26
Show member pathways
12.39 TNF IL6 IL1B IL17A IL10 CXCL8
27 12.39 TNF TLR4 IL6 IL1B CXCL8 CXCL1
28 12.36 TNF TLR4 TLR2 MMP9
29
Show member pathways
12.35 TNF TLR2 IL6 IL1B CXCL8
30
Show member pathways
12.34 TNF TLR9 IL6 IL1B IL10
31 12.34 TNF TLR9 TLR4 TLR2 MMP9 IL6
32 12.33 TNF IL6 IL1B IL10 CXCL8 AQP4
33
Show member pathways
12.33 TNF TLR9 TLR4 TLR2 IL6 IL1B
34 12.31 TNF TLR9 TLR4 TLR2 IL6 IL1B
35
Show member pathways
12.24 MBL2 CRP CR1 CFP
36 12.24 TNF TLR4 IL6 IL1B IL10 CXCL8
37
Show member pathways
12.18 TLR9 TLR4 TLR2 PIK3C2A IL1B
38 12.13 TNF MMP9 IL6 IL1B CXCL1
39 12.1 TNF TLR4 IL1B CXCL8 CXCL1 CCL4
40 12.1 TNF MMP9 IL6 IL1B IL17A IL10
41 12.09 TNF TLR4 MMP9 IL6 IL1B CXCL8
42 12.05 IL6 IL1B CXCL8 CXCL1
43
Show member pathways
12.04 TLR4 IL6 IL17A CXCL8 CXCL1
44 12.02 TNF IL6 IL1B CXCL8
45 12.01 TNF IL6 IL1B CR1
46
Show member pathways
12.01 TLR9 TLR4 TLR2 IL6 IL1B IL17A
47 11.98 TNF TLR4 TLR2 IL6 IL1B IL10
48 11.94 TLR9 TLR4 TLR2 CR1
49 11.92 TNF TLR9 IL6 IL1B IL10
50 11.91 TNF IL1B IL17A IL10

GO Terms for Bacterial Meningitis

Cellular components related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 TNF MMP9 MMP8 MBL2 IL6 IL1B
2 extracellular region GO:0005576 9.53 TNF TLR9 MMP9 MMP8 MBL2 IL6
3 tertiary granule lumen GO:1904724 9.46 MMP9 MMP8 CXCL1 CFP
4 specific granule lumen GO:0035580 9.43 MMP8 CXCL1 CFP

Biological processes related to Bacterial Meningitis according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.38 TLR9 TLR4 TLR2 IL6 IL1B IL10
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TNF TLR9 TLR4 TLR2 IL6 IL17A
3 immune system process GO:0002376 10.23 TLR9 TLR4 TLR2 MBL2 IL17A CR1
4 innate immune response GO:0045087 10.18 TLR9 TLR4 TLR2 MBL2 IL17A CRP
5 neutrophil degranulation GO:0043312 10.16 TLR2 MMP9 MMP8 CXCL1 CR1 CFP
6 negative regulation of cell proliferation GO:0008285 10.15 TLR2 IL6 IL1B IL10 CXCL8 CXCL1
7 defense response to bacterium GO:0042742 10.09 TNF TLR9 TLR4 MBL2 IL10 CFP
8 positive regulation of gene expression GO:0010628 10.09 TNF TLR9 TLR4 TLR2 MMP8 IL6
9 response to lipopolysaccharide GO:0032496 10.02 TLR4 TLR2 IL1B IL10
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.01 TNF TLR9 TLR4 TLR2 IL6 IL1B
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.99 TNF IL6 IL1B IL10
12 cellular response to interferon-gamma GO:0071346 9.97 TLR4 TLR2 CCL4 AQP4
13 defense response to Gram-negative bacterium GO:0050829 9.97 TLR9 TLR4 IL6 IL17A
14 positive regulation of inflammatory response GO:0050729 9.97 TNF TLR9 TLR4 TLR2 IL1B
15 defense response to Gram-positive bacterium GO:0050830 9.97 TNF TLR2 MBL2 IL6 IL17A CRP
16 negative regulation of interleukin-6 production GO:0032715 9.96 TNF TLR9 TLR4 IL10
17 positive regulation of JNK cascade GO:0046330 9.96 TNF TLR9 TLR4 MMP8 IL1B
18 cellular response to lipopolysaccharide GO:0071222 9.95 TNF TLR4 IL6 IL1B IL10 CXCL8
19 positive regulation of interferon-gamma production GO:0032729 9.94 TNF TLR9 TLR4 IL1B
20 positive regulation of interleukin-1 beta production GO:0032731 9.93 TNF TLR4 IL6 IL17A
21 positive regulation of tumor necrosis factor production GO:0032760 9.93 TLR9 TLR4 TLR2 MMP8 IL6 IL17A
22 neutrophil chemotaxis GO:0030593 9.92 CXCL8 CXCL1 CCL4
23 regulation of insulin secretion GO:0050796 9.92 TNF IL6 IL1B
24 positive regulation of nitric oxide biosynthetic process GO:0045429 9.92 TNF TLR4 MMP8 IL1B
25 chemokine-mediated signaling pathway GO:0070098 9.91 CXCL8 CXCL1 CCL4
26 response to glucocorticoid GO:0051384 9.91 TNF IL6 IL10
27 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.91 TNF TLR9 TLR4
28 positive regulation of interleukin-12 production GO:0032735 9.91 TLR9 TLR4 TLR2 IL17A
29 cytokine-mediated signaling pathway GO:0019221 9.91 TNF MMP9 IL6 IL1B IL17A IL10
30 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.9 TNF MMP9 IL10
31 toll-like receptor signaling pathway GO:0002224 9.89 TLR9 TLR4 TLR2
32 negative regulation of interferon-gamma production GO:0032689 9.89 TLR4 IL10 CR1
33 positive regulation of interleukin-10 production GO:0032733 9.89 TLR9 TLR4 TLR2 IL6
34 acute-phase response GO:0006953 9.88 MBL2 IL6 CRP
35 positive regulation of interferon-beta production GO:0032728 9.88 TLR9 TLR4 TLR2
36 lipopolysaccharide-mediated signaling pathway GO:0031663 9.88 TNF TLR4 TLR2 IL1B
37 positive regulation of chemokine production GO:0032722 9.88 TNF TLR9 TLR4 TLR2 IL6
38 positive regulation of JAK-STAT cascade GO:0046427 9.87 TNF IL6 IL10
39 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.87 TLR9 TLR4 TLR2
40 negative regulation of neurogenesis GO:0050768 9.85 TNF IL6 IL1B
41 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.85 TNF TLR4 IL6 IL17A
42 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR9 TLR4 TLR2 MMP8 IL1B
43 positive regulation of immunoglobulin production GO:0002639 9.84 TLR9 IL6 IL10
44 positive regulation of glial cell proliferation GO:0060252 9.83 TNF IL6 IL1B
45 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.83 TLR9 TLR4 TLR2
46 positive regulation of neuroinflammatory response GO:0150078 9.83 TNF MMP8 IL6 IL1B
47 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.82 TNF IL1B IL10
48 I-kappaB phosphorylation GO:0007252 9.81 TLR9 TLR4 TLR2
49 response to molecule of bacterial origin GO:0002237 9.81 TLR9 TLR2 IL10 CXCL8
50 regulation of neuroinflammatory response GO:0150077 9.8 MMP9 MMP8 IL6

Molecular functions related to Bacterial Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.86 TNF TLR4 TLR2 MMP9 CRP CCL4
2 chemokine activity GO:0008009 9.33 CXCL8 CXCL1 CCL4
3 cytokine activity GO:0005125 9.23 TNF IL6 IL1B IL17A IL10 CXCL8
4 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2

Sources for Bacterial Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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