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MCID: BCT021
MIFTS: 44

Bacterial Sepsis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bacterial Sepsis

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MalaCards integrated aliases for Bacterial Sepsis:

Name: Bacterial Sepsis 12 15

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040085
ICD9CM 34 995.91
SNOMED-CT 67 10001005
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Summaries for Bacterial Sepsis

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Disease Ontology : 12 A bacterial infectious disease has material basis in Bacteria.

MalaCards based summary : Bacterial Sepsis is related to sepsis in premature infants and perinatal necrotizing enterocolitis. An important gene associated with Bacterial Sepsis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs leucovorin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include liver, neutrophil and lung, and related phenotypes are hematopoietic system and cardiovascular system

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Related Diseases for Bacterial Sepsis

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Diseases related to Bacterial Sepsis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 502)
# Related Disease Score Top Affiliating Genes
1 sepsis in premature infants 32.4 CRP CALCA
2 perinatal necrotizing enterocolitis 30.6 TNF TLR4 IL10 CXCL8 CRP
3 haemophilus influenzae 30.6 TNF CXCL8
4 disseminated intravascular coagulation 30.5 TNF SELE IL10 ELANE CRP
5 candidiasis 30.5 TNF TLR4 IL10 CXCL8
6 smallpox 30.4 TNF IL1RN IL18
7 meningoencephalitis 30.3 TNF IL10 CRP
8 cellulitis 30.3 TNF IL10 CRP
9 bacterial meningitis 30.3 TNF TLR4 IL18 IL10 CXCL8 CRP
10 purpura 30.3 TNF IL10 CRP
11 bacteriuria 30.3 TLR4 IL18 CXCL8 CRP
12 exanthem 30.2 TNF IL1RN IL10 CXCL8 CRP
13 bronchopulmonary dysplasia 30.2 IL1RN ELANE CXCL8
14 toxoplasmosis 30.2 TNF TLR4 NOS2 IL10
15 shwartzman phenomenon 30.2 VCAM1 TNF TLR4 SELE
16 extrapulmonary tuberculosis 30.2 TNF IL1RN IL10 CRP
17 septic arthritis 30.1 TNF TLR4 CXCL8 CRP CALCA
18 neutropenia 30.1 TNF TLR4 IL1RN IL10 ELANE CXCL8
19 cholangitis 30.1 TNF TLR4 IL10 CXCL8 CRP
20 osteomyelitis 30.1 TNF TLR4 IL1RN IL10 CXCL8 CALCA
21 diarrhea 30.0 TNF TLR4 IL10 CXCL8 CALCA
22 acquired immunodeficiency syndrome 30.0 VCAM1 TNF SELE NOS2 IL10 CRP
23 allergic hypersensitivity disease 30.0 VCAM1 TNF SELE IL10 CXCL8
24 acute cystitis 29.9 TNF TLR4 IL18 IL10 CXCL8 CRP
25 lymphadenitis 29.9 TNF TLR4 IL18 IL10 CXCL8 CRP
26 meningitis 29.9 TNF TLR4 LBP IL18 IL10 CXCL8
27 glomerulonephritis 29.8 VCAM1 NOS2 MIF ELANE
28 toxic shock syndrome 29.8 TNF TLR4 NOS2 MIF LBP IL1RN
29 gastroenteritis 29.8 TNF IL1RN IL10 CXCL8 CRP CALCA
30 myeloma, multiple 29.8 VCAM1 TNF TLR4 IL10 CXCL8 CRP
31 myocarditis 29.8 VCAM1 TNF TLR4 NOS2 IL18 IL10
32 plasmodium falciparum malaria 29.8 TNF SELE NOS2 MIF IL18 IL10
33 visceral leishmaniasis 29.7 TNF TLR4 NOS2 IL18 IL10 CXCL8
34 leishmaniasis 29.7 TNF TLR4 NOS2 IL18 IL10 CXCL8
35 otitis media 29.6 TNF TLR4 IL1RN IL10 ELANE CXCL8
36 bacterial infectious disease 29.5 TNF TLR4 MIF LBP IL1RN IL18
37 thrombocytopenia 29.3 TNF TLR4 SELE PF4 IL1RN IL18
38 respiratory failure 29.3 TNF TLR4 PF4 IL1RN IL10 ELANE
39 peritonitis 29.2 VCAM1 TNF TLR4 NOS2 LBP IL18
40 malaria 28.1 VCAM1 TNF TLR4 SELE PF4 NOS2
41 punctate inner choroidopathy 10.7 TNF IL10
42 tropical endomyocardial fibrosis 10.6 TNF IL10
43 drug reaction with eosinophilia and systemic symptoms 10.6 TNF CRP
44 multifocal choroiditis 10.6 TNF IL10
45 idiopathic anterior uveitis 10.6 TNF CXCL8
46 prosthetic joint infection 10.6 TLR4 CRP
47 myelitis 10.6 TNF IL10 CXCL8
48 streptococcal toxic-shock syndrome 10.6 TNF CXCL8
49 metal allergy 10.6 TNF TLR4 IL10
50 acute transverse myelitis 10.6 IL10 CXCL8

Graphical network of the top 20 diseases related to Bacterial Sepsis:



Diseases related to Bacterial Sepsis
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Symptoms & Phenotypes for Bacterial Sepsis

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MGI Mouse Phenotypes related to Bacterial Sepsis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CD14 ELANE IL10 IL18 IL1RN LBP
2 cardiovascular system MP:0005385 10.06 CRP IL10 IL18 IL1RN NOS2 PTAFR
3 homeostasis/metabolism MP:0005376 10.03 CD14 CRP ELANE IL10 IL18 IL1RN
4 immune system MP:0005387 9.83 CD14 CRP ELANE IL10 IL18 IL1RN
5 integument MP:0010771 9.28 ELANE IL10 IL18 IL1RN NOS2 S1PR3
Sources

Drugs & Therapeutics for Bacterial Sepsis

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Drugs for Bacterial Sepsis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 6006 143
2
Sulfamethoxazole Approved Phase 4 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
4
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
5
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Immunoglobulins, Intravenous Phase 4
9 Immunoglobulin A Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Vitamin B Complex Phase 4
12 Folic Acid Antagonists Phase 4
13 Antiprotozoal Agents Phase 4
14 Antiparasitic Agents Phase 4
15 Folate Phase 4
16 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
17 Vitamin B9 Phase 4
18 Anti-Retroviral Agents Phase 4
19 Antimalarials Phase 4
20 Vaccines Phase 4
21
Vancomycin Approved Phase 3 1404-90-6 14969 441141
22
Amikacin Approved, Investigational, Vet_approved Phase 3 37517-28-5 37768
23
Cefazolin Approved Phase 3 25953-19-9 656510 33255
24 Antibiotics, Antitubercular Phase 3
25 Antibodies Phase 2, Phase 3
26 Immunoglobulins Phase 2, Phase 3
27 Antitubercular Agents Phase 3
28 Pharmaceutical Solutions Phase 2, Phase 3
29 Antibodies, Monoclonal Phase 2, Phase 3
30 methicillin Phase 2
31
Prednisolone phosphate Approved, Vet_approved Phase 1 302-25-0
32
Methylprednisolone Approved, Vet_approved Phase 1 83-43-2 6741
33
Methylprednisolone hemisuccinate Approved Phase 1 2921-57-5
34 Prednisolone acetate Approved, Vet_approved Phase 1 52-21-1
35
Prednisolone Approved, Vet_approved Phase 1 50-24-8 5755
36
Prednisolone hemisuccinate Experimental Phase 1 2920-86-7
37 Methylprednisolone Acetate Phase 1
38 Interleukin 1 Receptor Antagonist Protein Phase 1
39 Antirheumatic Agents Phase 1
40
Heparin Approved, Investigational 9005-49-6 46507594 772
41
Lithium carbonate Approved 554-13-2
42 Kava Approved, Investigational, Nutraceutical 9000-38-8
43 Antioxidants
44 Protective Agents
45 calcium heparin
46
Bilirubin 69853-43-6, 635-65-4 21252250 5280352
47 Liver Extracts
48 Fat Emulsions, Intravenous
49 Soy Bean
50 Soybean oil, phospholipid emulsion

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 A Prospective Study to Analyze the Efficacy of IgM Rich Immunoglobulin as an Adjunct to Antibiotics in the Treatment of Bacterial Sepsis in Very Low Birth Weight Preterm Neonates Completed NCT03403530 Phase 4 IgM rich Immunoglobin
2 Procalcitonin-Guided Antimicrobial Discontinuation Strategy in Critically Ill Patients With Suspected or Confirmed Bacterial Sepsis Completed NCT00250666 Phase 4
3 Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria Completed NCT03087890 Phase 4 Cotrimoxazole;Placebo
4 Non-specific Effects of Rabies Vaccine on the Incidence of Common Infectious Disease Episodes: a Randomized Controlled Trial Enrolling by invitation NCT03656198 Phase 4 Sterile Water Injection
5 Clinical Outcome of Newborn Infants With Suspected Nosocomial Coagulase-negative Staphylococcal Sepsis Treated With Cefazolin or Vancomycin. A Non-inferiority, Randomized, Controlled Trial Completed NCT01867138 Phase 3 Cefazolin;Vancomycin;Amikacin
6 Comparison of the Efficacy of a 7-day Versus 14-day Course of Intravenous Antibiotics in the Treatment of Uncomplicated Neonatal Bacterial Sepsis: a Randomized Controlled Non-inferiority Trial Not yet recruiting NCT03280147 Phase 3 7-day course of antibiotics;14-day course of antibiotics
7 PCSK9 Inhibitor: a New Tool to Fight Septic Shock Not yet recruiting NCT03634293 Phase 2, Phase 3 Alirocumab Injectable Product;Saline Solution
8 Multi-centre, Randomised, Open Label, Phase IIb Study to Compare the Efficacy, Safety and Pharmacokinetics (PK) of an Optimised Dosing to a Standard Dosing Regimen of Vancomycin in Neonates and Infants Aged ≤ 90 Days With Late Onset Bacterial Sepsis Known or Suspected to be Caused by Gram-positive Microorganisms Unknown status NCT02790996 Phase 2 Vancomycin
9 Randomized Placebo Controlled Trial of Subcutaneous rhIL-1A (Anakinra) in the Management of Hospitalized Pediatric and Adult Patients With Macrophage Activation Syndrome Recruiting NCT02780583 Phase 1 kineret;placebo
10 A Randomized, Partial-Blinded, Placebo-Controlled, Phase I Safety and Immunogenicity Study in Healthy Subjects of Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram Negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant Terminated NCT01164514 Phase 1 Placebo
11 Complications of Exchange Transfusion in Neonates Unknown status NCT03195049
12 Role of Innate Lymphoid Cells in the Immunosuppression of Septic Shock Unknown status NCT03297203
13 Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients Unknown status NCT01482988
14 Newborn Infection Control and Care Initiative for Health Facilities to Accelerate Reduction of Newborn Mortality Unknown status NCT02271737
15 Usefulness of Routine qSOFA Calculation at Triage to Fasten Antimicrobial Administration in Patients With Bacterial Infection in the Emergency Department: a Quasi-experimental Study Completed NCT03299894
16 Prospective Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis- Experience From a Tertiary Care Hospital in Pakistan Completed NCT03506152
17 Use of Procalcitonin-Guided Decision Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis: Prospective Randomized Intervention Trial Completed NCT00926497
18 Defects in Opsonophagocytosis in Premature Infants as a Factor for the Development of Neonatal Sepsis Completed NCT00866567
19 Defining Immunodeficiency in Heterotaxy Syndrome: Pilot Study Data Completed NCT01929967
20 The Effects of an Endotoxin Challenge on the Immune Response Elicited by a Subsequent Challenge With Fluenz in Healthy Volunteers, an Explorative Study Completed NCT02642237
21 Genotypes and Phenotypes in Pediatric SIRS and Sepsis (GAPPSS) Completed NCT02728401
22 Mechanisms of Inflammatory Liver Injury Completed NCT00011284
23 Early Detection and Diagnostic Performance of Bio-markers During Bacterial Sepsis: Multicentre Cohort Study in Intensive Care Completed NCT01378169
24 Low Dose Parenteral Fat for Prevention of Parenteral Nutrition Associated Cholestasis in Preterm Neonates Completed NCT01050660
25 Investigation of Inflammatory Parameters in a Perioperative Closed-meshed Standard Progress in CPB Patients Completed NCT02963480
26 The Efficacy of Neurophysiologically Based Occupational Therapy Intervention in the Neonatal Intensive Care Unit: An Exploratory Study Completed NCT00766051
27 Pilot Study of Low-Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock Recruiting NCT03343041
28 Diagnostic Performance of a New Bio-marker During Bacterial Sepsis Recruiting NCT02721134
29 An Audit Study on Management of Neonates With Neonatal Sepsis Admitted to Asyut University Children Hospital Recruiting NCT03634891
30 Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches Recruiting NCT04410263
31 Measurement of the Recovery and Lifespan of Red Blood Cells From Pathogen-Reduced, Stored Blood Units Using Cellular Biotinylation Recruiting NCT03384407
32 Characterization of the Inflammatory Profile of Patients With Macrophage Activation Syndrome Secondary to Bacterial Sepsis Not yet recruiting NCT03721809
33 Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings Not yet recruiting NCT04285021
34 Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis Withdrawn NCT02699905

Search NIH Clinical Center for Bacterial Sepsis

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Genetic Tests for Bacterial Sepsis

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Anatomical Context for Bacterial Sepsis

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MalaCards organs/tissues related to Bacterial Sepsis:

40
Liver, Neutrophil, Lung, T Cells, Bone, Endothelial, Kidney
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Publications for Bacterial Sepsis

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Articles related to Bacterial Sepsis:

(show top 50) (show all 1558)
# Title Authors PMID Year
1
The unique characteristics of COVID-19 coagulopathy. 61
32552865 2020
2
Coagulopathy in COVID-19. 61
32558075 2020
3
Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure. 61
32320677 2020
4
Antigen Receptor Specificity and Cell Location Influence the Diversification and Selection of the B-1a Cell Pool with Age. 61
32561570 2020
5
Etiologies of Thrombocytopenia in the Community Hospital: The Experience of 1 Hematologist. 61
31712096 2020
6
The contact system proteases play disparate roles in streptococcal sepsis. 61
31320552 2020
7
Transfusion rates and disease spectrum in neonates treated with blood transfusion in China. 61
32358367 2020
8
Scrub typhus as a rare cause of acute pyelonephritis: case report. 61
32375669 2020
9
Reevaluating the role of ferritin in the diagnosis of adult secondary hemophagocytic lymphohistiocytosis. 61
31991015 2020
10
The role of type 1 interferons in coagulation induced by gram-negative bacteria. 61
32016282 2020
11
Pro-inflammatory effects after platelet transfusion: a review. 61
32293034 2020
12
Blockade Of PD-1 Attenuated Postsepsis Aspergillosis Via The Activation of IFN-γ and The Dampening of IL-10. 61
31306346 2020
13
IL6-receptor antibody tocilizumab as salvage therapy in severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a retrospective analysis. 61
32086584 2020
14
Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. 61
32346117 2020
15
The roles of NLRP3 inflammasome in bacterial infection. 61
32305691 2020
16
An immune-cell signature of bacterial sepsis. 61
32066974 2020
17
Influence of Patient Characteristics on Antibiotic Use Rates Among Preterm Infants. 61
32170951 2020
18
Whole-exome sequencing for the identification of rare variants in primary immunodeficiency genes in children with sepsis - a prospective population-based cohort study. 61
32185379 2020
19
RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis. 61
32152555 2020
20
Toll-like receptor bioactivity in endothelial progenitor cells. 61
31754781 2020
21
Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis. 61
31916705 2020
22
Transfer of Hexon- and Penton-selected adenovirus-specific T cells for refractory adenovirus infection after haploidentical stem cell transplantation. 61
31643129 2020
23
Procalcitonin and Bacterial Sepsis in Burn Patients in South Africa. 61
31635838 2020
24
Pattern of bacterial profile and antibiotic susceptibility among neonatal sepsis cases at Cairo University Children Hospital. 61
32110181 2020
25
Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis. 61
31818960 2020
26
Management of HIV-infected patients in the intensive care unit. 61
32016535 2020
27
Checkpoint inhibitor therapy in preclinical sepsis models: a systematic review and meta-analysis. 61
32020483 2020
28
High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndrome. 61
32160261 2020
29
Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. 61
31907443 2020
30
[Composite adult T-cell leukemia/lymphoma and Epstein-Barr virus-positive diffuse large B-cell lymphoma]. 61
32378571 2020
31
Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria. 61
31693729 2020
32
PCR for the detection of pathogens in neonatal early onset sepsis. 61
31978082 2020
33
Fulminant Neisseria meningitidis septicaemia with purpura fulminans requiring limb amputation. 61
31879595 2020
34
Coxsackie Myocarditis with Severe Methicillin-resistant Staphylococcus aureus Sepsis, Multi-organ Dysfunction Syndrome, and Posterior Epidural Spinal Abscess: A Case Report. 61
32148355 2020
35
Assessment of novel biomarkers: sTREM-1, pentraxin-3 and pro-adrenomedullin in the early diagnosis of neonatal early onset sepsis. 61
31594258 2020
36
Infection profile in children and adolescents with bone marrow failures treated with allogeneic hematopoietic stem cell transplantation. 61
31587440 2019
37
Enteroviral infection in neonates. 61
31607572 2019
38
The Role of Serum Procalcitonin in Predicting Bacterial Sepsis in Patients With Hypothyroidism. 61
31361312 2019
39
Splenic Innate B1 B Cell Plasmablasts Produce Sustained Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Cytokines during Murine Malaria Infections. 61
31591168 2019
40
Perinatal outcome in women with bacterial sepsis: A cross-sectional study from West China. 61
31689830 2019
41
Diagnosis of bacterial sepsis: why are tests for bacteremia not sufficient? 61
31446810 2019
42
Platelet Proteasome Activity and Metabolism Is Upregulated during Bacterial Sepsis. 61
31783490 2019
43
Atmospheric pressure non-thermal plasma exposure reduces Pseudomonas aeruginosa lipopolysaccharide toxicity in vitro and in vivo. 61
31437578 2019
44
Isorhamnetin Has Potential for the Treatment of Escherichia coli-Induced Sepsis. 61
31689976 2019
45
Effect of O antigen ligase gene mutation on oxidative stress resistance and pathogenicity of NMEC strain RS218. 61
31400443 2019
46
Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination. 61
31545300 2019
47
Long-term Experience with Rapid Screening for Platelet Bacterial Contamination in a High-volume Transfusion Service. 61
31882425 2019
48
IL-10-producing regulatory B cells exhibit functional defects and play a protective role in severe endotoxic shock. 61
31536782 2019
49
Cumulative evidence for association of sepsis and retinopathy of prematurity. 61
31626109 2019
50
Gut Leakage of Fungal-Derived Inflammatory Mediators: Part of a Gut-Liver-Kidney Axis in Bacterial Sepsis. 61
30863955 2019
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Variations for Bacterial Sepsis

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Expression for Bacterial Sepsis

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Search GEO for disease gene expression data for Bacterial Sepsis.
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Pathways for Bacterial Sepsis

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Pathways related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.02 VCAM1 TNF TLR4 PTAFR NOS2 MIF
2
PEDF Induced Signaling 63
Show member pathways
 13.69 TNF TLR4 PF4 NOS2 MIF IL1RN
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.38 VCAM1 TNF PTAFR NOS2 LBP IL1RN
4
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.09 TNF TLR4 NOS2 LBP IL10 CXCL8
5
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.74 TNF TLR4 NOS2 IL1RN IL18 CXCL8
6
Immune response IL-23 signaling pathway 22
Show member pathways
 12.6 TNF NOS2 IL18 IL10 CD14
7
Shigellosis 36
12.42 TNF TLR4 IL18 CXCL8 CD14
8
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.35 TNF PF4 IL18 IL10 CXCL8 CXCL5
9
Salmonella infection (KEGG) 36
12.33 TNF TLR4 IL18 CXCL8 CD14
10
Toll Comparative Pathway 63
Show member pathways
 12.32 TNF TLR4 NOS2 MIF LBP CXCL8
11
Pathogenic Escherichia coli infection 36
12.27 TNF TLR4 IL18 CXCL8
12
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.26 TNF TLR4 CXCL8 CD14
13
Toxoplasmosis 36
Show member pathways
 12.26 TNF TLR4 NOS2 IL10
14
NOD-like receptor signaling pathway 36
12.23 TNF TLR4 IL18 CXCL8
15
Bacterial infections in CF airways 22
Show member pathways
 12.2 TNF TLR4 NOS2 LBP CXCL8 CD14
16
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.18 TNF IL1RN IL10 CXCL8
17
Tuberculosis 36
12.17 TNF TLR4 NOS2 LBP IL18 IL10
18
Yersinia infection 36
12.05 TNF TLR4 IL18 IL10 CXCL8
19
Spinal Cord Injury 1
12.04 TNF TLR4 NOS2 MIF CXCL8
20
TNF signaling pathway 36
12.01 VCAM1 TNF SELE CXCL5
21
IL27-mediated signaling events 1
Show member pathways
 11.98 TNF TLR4 IL18 IL10
22
NF-kB(NFkB) Pathway 66
11.96 TNF TLR4 LBP CD14
23
AGE-RAGE signaling pathway in diabetic complications 36
11.95 VCAM1 TNF SELE CXCL8
24
NF-kappa B signaling pathway 36
11.95 VCAM1 TNF TLR4 LBP CXCL8 CD14
25
Amoebiasis 36
11.92 TNF TLR4 NOS2 IL10 CXCL8 CD14
26
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.91 TLR4 LBP CXCL8 CD14
27
Rheumatoid arthritis 36
11.89 TNF TLR4 IL18 CXCL8 CXCL5
28
Interleukin-4 and 13 signaling 65
11.86 VCAM1 TNF NOS2 LBP IL18 IL10
29
Innate Lymphoid Cells Differentiation 64
11.78 TNF IL18 IL10
30
Dendritic Cells Developmental Lineage Pathway 64
11.74 TNF IL10 CD14
31
Lung fibrosis 1
11.67 TNF CXCL8 CALCA
32
Legionellosis 36
11.65 TNF TLR4 IL18 CXCL8 CD14
33
Transcription_NF-kB signaling pathway 22
11.63 TNF TLR4 LBP CD14
34
ATF-2 transcription factor network 1
11.6 SELE NOS2 CXCL8
35
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 VCAM1 TNF SELE NOS2 MIF CXCL8
36
MSP-RON Signaling 63
11.57 TNF TLR4 NOS2 IL18
37
IL-10 Pathway 63
11.39 TNF TLR4 IL10 CD14
38
Pertussis 36
11.38 TNF TLR4 NOS2 IL10 CXCL8 CXCL5
39
African trypanosomiasis 36
11.37 VCAM1 TNF SELE IL18 IL10
40
Interleukin-10 signaling 65
11.32 TNF PTAFR IL1RN IL18 IL10 CXCL8
41
Cellular roles of Anthrax toxin 1
11.15 VCAM1 TNF IL18
42
Overview of nanoparticle effects 1
11.08 TNF CXCL8 CRP
43
G-protein signaling_Rap2B regulation pathway 22
11.05 TNF PF4 IL18 IL10 CXCL8 CXCL5
44
Malaria 36
10.87 VCAM1 TNF TLR4 SELE IL18 IL10
45
MIF Action Through Endocytic Pathway 63
10.86 TLR4 MIF CD14
46
EV release from cardiac cells and their functional effects 1
10.65 TNF MIR150
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GO Terms for Bacterial Sepsis

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Cellular components related to Bacterial Sepsis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNF S1PR3 PF4 MIF LBP IL1RN
2 cell surface GO:0009986 9.7 VCAM1 TNF TLR4 MIF LBP ELANE
3 extracellular space GO:0005615 9.53 VCAM1 TNF SELE PF4 MIR150 MIF
4 lipopolysaccharide receptor complex GO:0046696 9.26 TLR4 CD14

Biological processes related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.11 TNF TLR4 PF4 IL18 CRP
2 immune response GO:0006955 10.06 TNF TLR4 PTAFR PF4 IL1RN IL18
3 regulation of cell proliferation GO:0042127 10 TNF PF4 NOS2 MIF
4 defense response to bacterium GO:0042742 9.99 TNF TLR4 NOS2 LBP IL10 ELANE
5 leukocyte migration GO:0050900 9.98 TNF SELE MIF ELANE
6 chemotaxis GO:0006935 9.96 PTAFR PF4 CXCL8 CXCL5
7 defense response GO:0006952 9.95 TNF PF4 CXCL8 CXCL5
8 response to lipopolysaccharide GO:0032496 9.92 TLR4 SELE PTAFR NOS2 LBP IL10
9 neutrophil chemotaxis GO:0030593 9.89 PF4 CXCL8 CXCL5
10 phagocytosis GO:0006909 9.88 TLR4 ELANE CD14
11 chemokine-mediated signaling pathway GO:0070098 9.88 PF4 CXCL8 CXCL5
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF TLR4 IL18 CD14
13 apoptotic signaling pathway GO:0097190 9.87 TNF TLR4 CD14
14 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.87 PF4 CXCL8 CXCL5
15 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.87 TNF TLR4 CD14
16 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 TNF PTAFR IL18 ELANE
17 response to glucocorticoid GO:0051384 9.86 TNF IL1RN IL10
18 positive regulation of MAP kinase activity GO:0043406 9.86 TNF MIF ELANE
19 negative regulation of tumor necrosis factor production GO:0032720 9.85 TLR4 LBP IL10
20 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR4 LBP
21 positive regulation of tumor necrosis factor production GO:0032760 9.85 TLR4 PTAFR PF4 MIF LBP CD14
22 cytokine-mediated signaling pathway GO:0019221 9.85 VCAM1 TNF PTAFR PF4 NOS2 LBP
23 positive regulation of interferon-gamma production GO:0032729 9.83 TNF TLR4 IL18 CD14
24 toll-like receptor signaling pathway GO:0002224 9.82 TLR4 LBP CD14
25 negative regulation of interleukin-6 production GO:0032715 9.81 TNF TLR4 IL10
26 leukocyte cell-cell adhesion GO:0007159 9.8 VCAM1 SELE CALCA
27 negative regulation of blood pressure GO:0045776 9.8 PTAFR NOS2 CALCA
28 positive regulation of chemokine production GO:0032722 9.79 TNF TLR4 LBP
29 leukocyte tethering or rolling GO:0050901 9.79 VCAM1 TNF SELE
30 positive regulation of macrophage activation GO:0043032 9.78 TLR4 LBP IL10
31 positive regulation of cytokine secretion GO:0050715 9.78 TNF MIF IL10 CD14
32 toll-like receptor 4 signaling pathway GO:0034142 9.77 TLR4 LBP CD14
33 positive regulation of interleukin-8 secretion GO:2000484 9.77 TNF TLR4 CD14
34 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.76 TNF TLR4 ELANE
35 positive regulation of interleukin-8 production GO:0032757 9.76 TNF TLR4 LBP CALCA
36 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.73 TNF TLR4 MIF
37 leukocyte chemotaxis GO:0030595 9.73 PF4 IL10 CXCL8 CXCL5
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.73 TNF TLR4 PTAFR LBP IL18 CD14
39 positive regulation of neuroinflammatory response GO:0150078 9.72 TNF IL18
40 neutrophil activation GO:0042119 9.72 IL18 CXCL8
41 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL1RN IL10
42 leukocyte migration involved in inflammatory response GO:0002523 9.72 SELE ELANE
43 response to molecule of bacterial origin GO:0002237 9.72 IL10 CXCL8 CD14
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.71 TLR4 IL10
45 T-helper 1 type immune response GO:0042088 9.71 TLR4 IL18
46 negative regulation of lipid storage GO:0010888 9.71 TNF CRP
47 cellular response to lipoteichoic acid GO:0071223 9.71 TLR4 LBP CD14
48 opsonization GO:0008228 9.7 LBP CRP
49 endothelial cell apoptotic process GO:0072577 9.68 TNF IL10
50 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.68 TLR4 CD14

Molecular functions related to Bacterial Sepsis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.36 TNF TLR4 SELE S1PR3 PTAFR PF4
2 chemokine activity GO:0008009 9.54 PF4 CXCL8 CXCL5
3 lipopeptide binding GO:0071723 9.43 LBP CD14
4 CXCR chemokine receptor binding GO:0045236 9.33 PF4 CXCL8 CXCL5
5 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 PTAFR
6 lipoteichoic acid binding GO:0070891 9.26 LBP CD14
7 lipopolysaccharide binding GO:0001530 9.26 TLR4 PTAFR LBP CD14
8 cytokine activity GO:0005125 9.23 TNF PF4 MIF IL1RN IL18 IL10
Sources

Sources for Bacterial Sepsis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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