MCID: BCT021
MIFTS: 43

Bacterial Sepsis

Categories: Infectious diseases

Aliases & Classifications for Bacterial Sepsis

MalaCards integrated aliases for Bacterial Sepsis:

Name: Bacterial Sepsis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040085
ICD9CM 34 995.91
SNOMED-CT 67 10001005

Summaries for Bacterial Sepsis

Disease Ontology : 12 A bacterial infectious disease has material basis in Bacteria.

MalaCards based summary : Bacterial Sepsis is related to sepsis in premature infants and severe acute respiratory syndrome. An important gene associated with Bacterial Sepsis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, neutrophil and endothelial, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Bacterial Sepsis

Diseases related to Bacterial Sepsis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 535)
# Related Disease Score Top Affiliating Genes
1 sepsis in premature infants 31.7 CRP CALCA
2 severe acute respiratory syndrome 30.6 TNF TLR4 IL10 CXCL8 CRP
3 disseminated intravascular coagulation 30.6 TNF IL10 ELANE CRP
4 haemophilus influenzae 30.5 TNF CXCL8
5 perinatal necrotizing enterocolitis 30.4 TNF TLR9 TLR4 IL10 CXCL8 CRP
6 candidiasis 30.4 TNF TLR4 IL10 CXCL8
7 smallpox 30.3 TNF IL1RN IL18
8 enterocolitis 30.3 TNF TLR4 IL10 CXCL8 CRP CD14
9 urinary tract infection 30.3 TLR4 CRP
10 exanthem 30.3 TNF IL18 IL10 CXCL8 CRP
11 meningoencephalitis 30.3 TNF IL10 CRP
12 neutropenia 30.2 TNF TLR4 IL1RN IL10 ELANE CXCL8
13 shwartzman phenomenon 30.2 VCAM1 TNF SELE
14 purpura 30.2 TNF IL10 CRP
15 bacteriuria 30.2 TLR4 IL18 CXCL8 CRP
16 toxoplasmosis 30.2 TNF TLR9 TLR4 IL10
17 bacterial meningitis 30.2 TNF TLR9 TLR4 IL18 IL10 CXCL8
18 allergic disease 30.1 TNF TLR9 TLR4 IL18
19 bronchopulmonary dysplasia 30.1 IL1RN ELANE CXCL8
20 toxic shock syndrome 30.1 TNF TLR4 NOS2 MIF LBP IL1RN
21 klebsiella pneumonia 30.1 TNF TLR4 IL10 CXCL8 CRP
22 otitis media 30.1 TNF TLR4 IL10 CXCL8 CRP
23 cholangitis 30.1 TNF TLR4 IL10 CXCL8 CRP
24 septic arthritis 30.1 TLR9 TLR4 CXCL8 CRP CALCA
25 extrapulmonary tuberculosis 30.1 LBP IL1RN IL10 CRP
26 diarrhea 30.1 TNF TLR4 IL10 CXCL8 CALCA
27 acquired immunodeficiency syndrome 30.0 VCAM1 TNF SELE NOS2 IL10 CRP
28 meningitis 30.0 TNF TLR9 TLR4 LBP IL18 IL10
29 disease by infectious agent 30.0 TNF TLR9 TLR4 LBP IL1RN IL18
30 osteomyelitis 30.0 TNF TLR4 IL1RN IL10 CXCL8 CRP
31 acute cystitis 29.9 TNF TLR4 IL18 IL10 CXCL8 CRP
32 lymphadenitis 29.9 TNF TLR4 IL18 IL10 CXCL8 CRP
33 leishmaniasis 29.9 TNF TLR9 TLR4 NOS2 IL18 IL10
34 peritonitis 29.9 TNF TLR4 LBP IL18 IL10 ELANE
35 plasmodium falciparum malaria 29.9 TNF SELE NOS2 MIF IL18 IL10
36 glomerulonephritis 29.9 VCAM1 NOS2 MIF ELANE
37 myocarditis 29.8 VCAM1 TNF TLR4 NOS2 IL18 IL10
38 liver cirrhosis 29.8 TNF TLR4 LBP IL10 CRP CD14
39 gastroenteritis 29.7 TNF TLR9 IL1RN IL10 CXCL8 CRP
40 bacterial infectious disease 29.7 TNF TLR9 TLR4 MIF LBP IL1RN
41 endocarditis 29.7 VCAM1 TNF PF4 LBP IL10 CXCL8
42 thrombocytopenia 29.6 TNF TLR9 TLR4 SELE PF4 IL1RN
43 cystic fibrosis 29.6 TNF TLR4 NOS2 LBP IL10 ELANE
44 body mass index quantitative trait locus 11 29.5 VCAM1 TNF TLR4 SELE IL18 IL10
45 respiratory failure 29.4 TNF TLR4 PF4 IL1RN IL10 ELANE
46 pre-eclampsia 29.4 VCAM1 TNF TLR4 SELE NOS2 IL18
47 visceral leishmaniasis 29.4 TNF TLR9 TLR4 NOS2 MIF IL18
48 arthritis 29.0 VCAM1 TNF TLR4 MIF IL1RN IL18
49 adult respiratory distress syndrome 28.8 TNF SELE NOS2 MIF LBP IL1RN
50 malaria 28.6 VCAM1 TNF TLR9 TLR4 SELE PF4

Graphical network of the top 20 diseases related to Bacterial Sepsis:



Diseases related to Bacterial Sepsis

Symptoms & Phenotypes for Bacterial Sepsis

MGI Mouse Phenotypes related to Bacterial Sepsis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CD14 ELANE IL10 IL18 IL1RN LBP
2 cardiovascular system MP:0005385 10.06 CRP IL10 IL18 IL1RN NOS2 PTAFR
3 homeostasis/metabolism MP:0005376 10.06 CD14 CRP ELANE IL10 IL18 IL1RN
4 immune system MP:0005387 9.86 CD14 CRP ELANE IL10 IL18 IL1RN
5 integument MP:0010771 9.28 ELANE IL10 IL18 IL1RN NOS2 S1PR3

Drugs & Therapeutics for Bacterial Sepsis

Drugs for Bacterial Sepsis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular Phase 4
2 Anti-Bacterial Agents Phase 4
3 Immunoglobulins Phase 4
4 Antibodies Phase 4
5 Immunoglobulin A Phase 4
6 Immunoglobulins, Intravenous Phase 4
7 Anti-Infective Agents Phase 3
8 Antitubercular Agents Phase 3
9
Vancomycin Approved Phase 2 1404-90-6 441141 14969
10 methicillin Phase 2
11 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Procalcitonin-Guided Antimicrobial Discontinuation Strategy in Critically Ill Patients With Suspected or Confirmed Bacterial Sepsis Completed NCT00250666 Phase 4
2 A Prospective Study to Analyze the Efficacy of IgM Rich Immunoglobulin as an Adjunct to Antibiotics in the Treatment of Bacterial Sepsis in Very Low Birth Weight Preterm Neonates Completed NCT03403530 Phase 4 IgM rich Immunoglobin
3 Comparison of the Efficacy of a 7-day Versus 14-day Course of Intravenous Antibiotics in the Treatment of Uncomplicated Neonatal Bacterial Sepsis: a Randomized Controlled Non-inferiority Trial Recruiting NCT03280147 Phase 3 7-day course of antibiotics;14-day course of antibiotics
4 Multi-centre, Randomised, Open Label, Phase IIb Study to Compare the Efficacy, Safety and Pharmacokinetics (PK) of an Optimised Dosing to a Standard Dosing Regimen of Vancomycin in Neonates and Infants Aged ≤ 90 Days With Late Onset Bacterial Sepsis Known or Suspected to be Caused by Gram-positive Microorganisms Terminated NCT02790996 Phase 2 Vancomycin
5 A Randomized, Partial-Blinded, Placebo-Controlled, Phase I Safety and Immunogenicity Study in Healthy Subjects of Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram Negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant Terminated NCT01164514 Phase 1 Placebo
6 Diagnostic Performance of a New Bio-marker During Bacterial Sepsis Unknown status NCT02721134
7 Characterization of the Inflammatory Profile of Patients With Macrophage Activation Syndrome Secondary to Bacterial Sepsis Unknown status NCT03721809
8 Early Detection and Diagnostic Performance of Bio-markers During Bacterial Sepsis: Multicentre Cohort Study in Intensive Care Completed NCT01378169
9 Pilot Study of Low-Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock Recruiting NCT03343041

Search NIH Clinical Center for Bacterial Sepsis

Genetic Tests for Bacterial Sepsis

Anatomical Context for Bacterial Sepsis

MalaCards organs/tissues related to Bacterial Sepsis:

40
Liver, Neutrophil, Endothelial, Kidney, Bone, Bone Marrow, Myeloid

Publications for Bacterial Sepsis

Articles related to Bacterial Sepsis:

(show top 50) (show all 1627)
# Title Authors PMID Year
1
Do isolates from pharyngeal and rectal swabs match blood culture bacterial pathogens in septic VLBW infants? A pilot, cross-sectional study. 61
32860099 2021
2
A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood. 61
33536218 2021
3
Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission. 61
33547747 2021
4
Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019. 61
33201004 2021
5
IOX1 activity as sepsis therapy and an antibiotic against multidrug-resistant bacteria. 61
33536477 2021
6
A pregnancy-specific reference interval for procalcitonin. 61
33307062 2021
7
Mycotic Aneurysm of Brachial Artery in Case of Aplastic Anemia. 61
33527820 2021
8
Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. 61
33556539 2021
9
Platelet FcγRIIA in Immunity and Thrombosis: Adaptive Immunothrombosis. 61
33587783 2021
10
Key challenges in providing effective antibiotic therapy for critically ill patients with bacterial sepsis and septic shock. 61
33570163 2021
11
Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis. 61
33588136 2021
12
Relationship between influenza and dengue outbreaks, and subsequent bacterial sepsis in French Guiana: A time series analysis. 61
33553058 2021
13
Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis. 61
33497603 2021
14
Time for pragmatic, prospective clinical trials to determine the role of empirical antibacterial therapy in critically ill adults hospitalized with malaria. 61
33017698 2021
15
Therapeutic plasma exchange followed by convalescent plasma transfusion in critical COVID-19-An exploratory study. 61
33157287 2021
16
Vancomycin in neonatal sepsis: predictive performance of a Chinese neonatal population pharmacokinetic model and clinical efficacy evaluation. 61
33472817 2021
17
Hemophagocytic Lymphohistiocytosis in a PICU of a Developing Economy: Clinical Profile, Intensive Care Needs, Outcome, and Predictors of Mortality. 61
33031348 2021
18
Inertial-based Fluidic Platform for Rapid Isolation of Blood-borne Pathogens. 61
33499487 2021
19
The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review. 61
33495945 2021
20
Omega-3 fatty acid lipid emulsions are safe and effective in reducing endotoxemia and sepsis in acute-on-chronic liver failure: An open-label randomized controlled trial. 61
33450081 2021
21
HTLV-I and Strongyloides in Australia: The worm lurking beneath. 61
33482974 2021
22
Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis. 61
33333514 2021
23
Diagnosis of Neonatal Late-Onset Infection in Very Preterm Infant: Inter-Observer Agreement and International Classifications. 61
33498557 2021
24
Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis. 61
33438259 2021
25
COVID-19: should we consider it as a septic shock? (The treatment of COVID-19 patients in the ICU). 61
33470663 2021
26
Peritoneal dialysis in critically ill children in resource-limited setting: A prospective cohort study. 61
33272115 2020
27
Sepsis and Cancer: An Interplay of Friends and Foes. 61
32813980 2020
28
Effects of hypercapnia in sepsis: A scoping review of clinical and pre-clinical data. 61
33315238 2020
29
Novel TLR2xTLR4 Bispecific Antibody Inhibits Bacterial Sepsis. 61
33347385 2020
30
Ampicillin triggers the release of Pal in toxic vesicles from Escherichia coli. 61
32941946 2020
31
Endotoxemia and circulating bacteriome in severe COVID-19 patients. 61
33284413 2020
32
Interleukin-10 (IL-10) 1082 promoter Polymorphisms and plasma IL-10 levels in patients with bacterial sepsis. 61
33155998 2020
33
Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. 61
33208501 2020
34
Outcomes with nondose-dense chemotherapy for Ewing sarcoma: A practical approach for the developing world. 61
32706522 2020
35
Individualized versus standard diet fortification for growth and development in preterm infants receiving human milk. 61
33226632 2020
36
Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study. 61
33239110 2020
37
Compassionate use of remdesivir in children with COVID-19. 61
33200304 2020
38
miRNA-23b as a biomarker of culture-positive neonatal sepsis. 61
33032520 2020
39
The effect of foal or adult horse plasma on equine monocyte-derived dendritic cell phenotype and function. 61
32717449 2020
40
Temporal changes of NF-κB signaling pathway genes in bacterial stimulated whole blood- a host mechanism associated with sepsis. 61
32738283 2020
41
Impact of Aeromonas hydrophila and infectious spleen and kidney necrosis virus infections on susceptibility and host immune response in Chinese perch (Siniperca chuatsi). 61
32653585 2020
42
Respiratory viral sepsis: epidemiology, pathophysiology, diagnosis and treatment. 61
32699026 2020
43
One disease, many faces-typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease. 61
33024752 2020
44
Evaluation of Inflammatory Biomarkers in Pediatric Hematology-Oncology Patients With Bloodstream Infection. 61
32941295 2020
45
Magnitude, trend, and causes of under-five mortality from Kilite-Awlaelo health demographic surveillance database, northern Ethiopia, 2009-2017. 61
32993625 2020
46
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome. 61
32826331 2020
47
RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis. 61
32152555 2020
48
Coagulopathy in COVID-19. 61
32558075 2020
49
Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19. 61
32908980 2020
50
Sepsis from an apheresis platelet contaminated with Acinetobacter calcoaceticus/baumannii complex bacteria and Staphylococcus saprophyticus after pathogen reduction. 61
32738079 2020

Variations for Bacterial Sepsis

Expression for Bacterial Sepsis

Search GEO for disease gene expression data for Bacterial Sepsis.

Pathways for Bacterial Sepsis

Pathways related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 VCAM1 TNF TLR9 TLR4 PTAFR NOS2
2
Show member pathways
13.71 TNF TLR4 PF4 NOS2 MIF IL1RN
3
Show member pathways
13.43 TNF TLR9 TLR4 PF4 IL18 IL10
4
Show member pathways
13.4 VCAM1 TNF PTAFR NOS2 LBP IL1RN
5
Show member pathways
13.09 TNF TLR9 TLR4 NOS2 LBP IL10
6
Show member pathways
12.81 TNF TLR9 TLR4 IL18 CXCL8
7
Show member pathways
12.78 TNF TLR9 TLR4 IL18 CXCL8 CD14
8
Show member pathways
12.75 TNF TLR9 TLR4 NOS2 IL1RN IL18
9
Show member pathways
12.61 TNF NOS2 IL18 IL10 CD14
10 12.59 VCAM1 TNF TLR9 IL1RN IL10
11 12.45 TNF TLR4 IL18 CXCL8 CD14
12
Show member pathways
12.39 TNF PF4 IL18 IL10 CXCL8 CXCL5
13
Show member pathways
12.36 TNF TLR4 NOS2 MIF LBP CXCL8
14
Show member pathways
12.31 TNF TLR9 TLR4 CXCL8 CD14
15
Show member pathways
12.27 TNF TLR4 NOS2 IL10
16 12.25 TNF TLR4 IL18 CXCL8
17
Show member pathways
12.22 TNF TLR9 TLR4 NOS2 LBP CXCL8
18 12.21 TNF TLR9 TLR4 NOS2
19 12.2 TNF IL1RN IL10 CXCL8
20 12.15 TNF TLR4 IL18 IL10 CXCL8
21 12.11 TNF TLR9 TLR4 NOS2 LBP IL18
22 12.07 TNF TLR4 NOS2 MIF CXCL8
23 12.02 VCAM1 TNF SELE CXCL5
24 11.99 VCAM1 TNF TLR4 LBP CXCL8 CD14
25 11.97 VCAM1 TNF NOS2 LBP IL18 IL10
26 11.96 VCAM1 TNF SELE CXCL8
27 11.96 TNF TLR4 NOS2 IL10 CXCL8 CD14
28 11.93 TNF TLR4 IL18 CXCL8 CXCL5
29
Show member pathways
11.92 TLR4 LBP CXCL8 CD14
30
Show member pathways
11.84 TNF TLR9 TLR4 IL18 IL10
31 11.81 TNF TLR9 IL10 CD14
32 11.78 TNF IL18 IL10
33 11.73 VCAM1 TNF TLR9 TLR4 NOS2 IL10
34 11.69 TNF TLR4 IL18 CXCL8 CD14
35
Show member pathways
11.68 VCAM1 TNF SELE NOS2 MIF CXCL8
36 11.67 TNF CXCL8 CALCA
37 11.65 TNF TLR4 LBP CD14
38 11.61 SELE NOS2 CXCL8
39 11.59 TNF TLR4 NOS2 IL18
40 11.49 TNF PTAFR IL1RN IL18 IL10 CXCL8
41 11.43 TNF TLR4 IL10 CD14
42 11.38 TNF TLR4 NOS2 IL10 CXCL8 CXCL5
43 11.2 VCAM1 TNF TLR9 SELE IL18 IL10
44 11.17 VCAM1 TNF IL18
45 11.1 TNF CXCL8 CRP
46 11.05 TNF PF4 IL18 IL10 CXCL8 CXCL5
47 10.92 VCAM1 TNF TLR9 TLR4 SELE IL18
48 10.88 TLR4 MIF CD14

GO Terms for Bacterial Sepsis

Cellular components related to Bacterial Sepsis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TNF TLR9 S1PR3 PF4 MIF LBP
2 cell surface GO:0009986 9.7 VCAM1 TNF TLR4 MIF LBP ELANE
3 extracellular space GO:0005615 9.5 VCAM1 TNF SELE PF4 MIF LBP
4 lipopolysaccharide receptor complex GO:0046696 9.26 TLR4 CD14

Biological processes related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.33 TLR9 TLR4 S1PR3 PTAFR IL1RN IL18
2 innate immune response GO:0045087 10.14 TLR9 TLR4 MIF LBP CRP CD14
3 immune response GO:0006955 10.13 TNF TLR9 TLR4 PTAFR PF4 IL1RN
4 positive regulation of gene expression GO:0010628 10.12 TNF TLR9 TLR4 PF4 IL18 CXCL8
5 defense response to bacterium GO:0042742 10.02 TNF TLR9 TLR4 NOS2 LBP IL10
6 leukocyte migration GO:0050900 9.99 TNF SELE MIF ELANE
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TLR9 TLR4 IL18
8 chemotaxis GO:0006935 9.97 PTAFR PF4 CXCL8 CXCL5
9 defense response GO:0006952 9.97 TNF PF4 CXCL8 CXCL5
10 cytokine-mediated signaling pathway GO:0019221 9.96 VCAM1 TNF PTAFR PF4 NOS2 LBP
11 positive regulation of tumor necrosis factor production GO:0032760 9.95 TLR9 TLR4 PTAFR PF4 MIF LBP
12 positive regulation of inflammatory response GO:0050729 9.93 TNF TLR9 TLR4 IL18
13 defense response to Gram-negative bacterium GO:0050829 9.93 TLR9 TLR4 NOS2 LBP
14 positive regulation of interleukin-6 production GO:0032755 9.92 TNF TLR9 TLR4 PTAFR LBP
15 negative regulation of interleukin-6 production GO:0032715 9.91 TNF TLR9 TLR4 IL10
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TNF TLR9 TLR4 IL18 CD14
17 positive regulation of JNK cascade GO:0046330 9.9 TNF TLR9 TLR4
18 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.9 TNF TLR9 TLR4 CD14
19 neutrophil chemotaxis GO:0030593 9.89 PF4 CXCL8 CXCL5
20 phagocytosis GO:0006909 9.89 TLR4 ELANE CD14
21 negative regulation of tumor necrosis factor production GO:0032720 9.89 TLR4 LBP IL10
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 TNF PTAFR IL18 ELANE
23 positive regulation of interferon-gamma production GO:0032729 9.89 TNF TLR9 TLR4 IL18 CD14
24 apoptotic signaling pathway GO:0097190 9.88 TNF TLR4 CD14
25 chemokine-mediated signaling pathway GO:0070098 9.88 PF4 CXCL8 CXCL5
26 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.88 PF4 CXCL8 CXCL5
27 positive regulation of cytokine production GO:0001819 9.88 TNF MIF IL10 CD14
28 response to glucocorticoid GO:0051384 9.87 TNF IL1RN IL10
29 positive regulation of interleukin-8 production GO:0032757 9.87 TNF TLR9 TLR4 LBP ELANE CD14
30 toll-like receptor signaling pathway GO:0002224 9.86 TLR9 TLR4 LBP CD14
31 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TNF TLR4 PTAFR LBP IL18 CD14
32 positive regulation of chemokine production GO:0032722 9.84 TNF TLR9 TLR4 LBP
33 negative regulation of interleukin-8 production GO:0032717 9.83 TLR9 IL10 ELANE
34 positive regulation of B cell proliferation GO:0030890 9.83 TLR9 TLR4 MIF
35 acute-phase response GO:0006953 9.83 LBP IL1RN CRP
36 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.82 TLR9 TLR4 CD14
37 leukocyte cell-cell adhesion GO:0007159 9.82 VCAM1 SELE CALCA
38 negative regulation of blood pressure GO:0045776 9.81 PTAFR NOS2 CALCA
39 response to lipopolysaccharide GO:0032496 9.81 VCAM1 TLR4 SELE PTAFR NOS2 LBP
40 leukocyte tethering or rolling GO:0050901 9.8 VCAM1 TNF SELE
41 positive regulation of macrophage activation GO:0043032 9.79 TLR4 LBP IL10
42 toll-like receptor 4 signaling pathway GO:0034142 9.79 TLR4 LBP CD14
43 response to molecule of bacterial origin GO:0002237 9.76 TLR9 IL10 CXCL8 CD14
44 cellular response to lipoteichoic acid GO:0071223 9.74 TLR4 LBP CD14
45 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF IL18
46 I-kappaB phosphorylation GO:0007252 9.73 TLR9 TLR4
47 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 TLR4 IL10
48 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL1RN IL10
49 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.72 TNF TLR4
50 positive regulation of leukocyte tethering or rolling GO:1903238 9.72 SELE PTAFR ELANE

Molecular functions related to Bacterial Sepsis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.41 TNF TLR9 TLR4 SELE S1PR3 PTAFR
2 chemokine activity GO:0008009 9.54 PF4 CXCL8 CXCL5
3 lipopeptide binding GO:0071723 9.4 LBP CD14
4 CXCR chemokine receptor binding GO:0045236 9.33 PF4 CXCL8 CXCL5
5 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 PTAFR
6 lipoteichoic acid binding GO:0070891 9.26 LBP CD14
7 lipopolysaccharide binding GO:0001530 9.26 TLR4 PTAFR LBP CD14
8 cytokine activity GO:0005125 9.23 TNF PF4 MIF IL1RN IL18 IL10

Sources for Bacterial Sepsis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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