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MCID: BCT021
MIFTS: 47

Bacterial Sepsis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bacterial Sepsis

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MalaCards integrated aliases for Bacterial Sepsis:

Name: Bacterial Sepsis 12 15

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040085
ICD9CM 36 995.91
SNOMED-CT 69 17463016
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Summaries for Bacterial Sepsis

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Disease Ontology : 12 A bacterial infectious disease has material basis in Bacteria.

MalaCards based summary : Bacterial Sepsis is related to sepsis in premature infants and meningitis. An important gene associated with Bacterial Sepsis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Glycine and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

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Related Diseases for Bacterial Sepsis

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Diseases related to Bacterial Sepsis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 sepsis in premature infants 31.8 CALCA CRP
2 meningitis 29.9 CRP CXCL8 IL10 TNF
3 osteomyelitis 29.8 CXCL8 IL10 TNF
4 perinatal necrotizing enterocolitis 29.7 CRP CXCL8 TLR4 TNF
5 plasmodium falciparum malaria 29.6 IL10 SELE TNF
6 lymphadenitis 29.6 CXCL8 IL10 TLR4 TNF
7 otitis media 29.6 CXCL8 IL10 TLR4 TNF
8 respiratory failure 29.5 CRP CXCL8 ELANE TNF
9 leishmaniasis 29.4 IL10 NOS2 TLR4 TNF
10 peritonitis 29.3 CRP CXCL8 IL10 LBP TNF
11 visceral leishmaniasis 29.1 CXCL8 IL10 NOS2 TLR4 TNF
12 rheumatoid arthritis 28.9 CRP CXCL8 IL10 SELE TLR4 TNF
13 malaria 28.6 CRP CXCL8 IL10 NOS2 SELE TLR4
14 streptococcal meningitis 10.4 CRP TNF
15 tuberculous peritonitis 10.4 CRP TNF
16 relapsing fever 10.4 CRP TNF
17 dental pulp disease 10.4 CXCL8 TNF
18 mycobacterium abscessus 10.4 CXCL8 TNF
19 trench fever 10.4 TLR4 TNF
20 drug reaction with eosinophilia and systemic symptoms 10.4 CRP TNF
21 toxic pneumonitis 10.4 LBP TLR4
22 coccidioidomycosis 10.4 IL10 TLR4
23 suppurative thyroiditis 10.4 CALCA CRP
24 discitis 10.4 CALCA CRP
25 exudative glomerulonephritis 10.4 CXCL8 TNF
26 punctate inner choroidopathy 10.3 IL10 TNF
27 acute cholangitis 10.3 CALCA CRP
28 tropical endomyocardial fibrosis 10.3 IL10 TNF
29 salpingitis 10.3 CRP TNF
30 endomyocardial fibrosis 10.3 IL10 TNF
31 dental abscess 10.3 CRP TLR4
32 streptococcal toxic-shock syndrome 10.3 CXCL8 TNF
33 rheumatoid vasculitis 10.3 SELE TNF
34 myasthenic syndrome, congenital, 1a, slow-channel 10.3 CRP CXCL8
35 engraftment syndrome 10.3 CALCA CXCL8
36 multifocal choroiditis 10.3 IL10 TNF
37 choroiditis 10.3 IL10 TNF
38 pyuria 10.3 CRP CXCL8
39 transient hypogammaglobulinemia 10.3 IL10 TNF
40 chronic pyelonephritis 10.3 CALCA TLR4
41 cardiac sarcoidosis 10.3 CXCL8 TNF
42 cow milk allergy 10.3 IL10 TNF
43 status asthmaticus 10.3 CXCL8 ELANE
44 trichuriasis 10.3 IL10 TNF
45 haemophilus influenzae 10.3 CXCL8 TNF
46 opisthorchiasis 10.3 CXCL8 TNF
47 suppurative otitis media 10.3 CRP TLR4
48 mucocutaneous leishmaniasis 10.3 IL10 TNF
49 acute transverse myelitis 10.3 CXCL8 IL10
50 chronic active epstein-barr virus infection 10.3 IL10 SELE

Graphical network of the top 20 diseases related to Bacterial Sepsis:



Diseases related to Bacterial Sepsis
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Symptoms & Phenotypes for Bacterial Sepsis

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MGI Mouse Phenotypes related to Bacterial Sepsis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.02 CD14 ELANE IL10 LBP NOS2 S1PR3
2 homeostasis/metabolism MP:0005376 10.02 CD14 CRP ELANE IL10 LBP NOS2
3 immune system MP:0005387 9.96 CD14 CRP ELANE IL10 LBP NOS2
4 cardiovascular system MP:0005385 9.95 CRP IL10 NOS2 S1PR3 SELE TLR4
5 liver/biliary system MP:0005370 9.63 IL10 LBP NOS2 SELE TLR4 TNF
6 neoplasm MP:0002006 9.35 ELANE IL10 NOS2 TLR4 TNF
7 respiratory system MP:0005388 9.17 CD14 IL10 NOS2 S1PR3 SELE TLR4
Sources

Drugs & Therapeutics for Bacterial Sepsis

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Drugs for Bacterial Sepsis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
2 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
3 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
4 Immunoglobulins Phase 4,Phase 3
5 Immunologic Factors Phase 4,Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Immunoglobulin A Phase 4
8 Antitubercular Agents Phase 4,Phase 3,Not Applicable
9 Antibodies Phase 4,Phase 3
10 Vaccines Phase 4,Phase 1
11
Cefazolin Approved Phase 3 25953-19-9 33255 656510
12
Vancomycin Approved Phase 3,Phase 2 1404-90-6 14969 441141
13
Amikacin Approved, Investigational, Vet_approved Phase 3 37517-28-5 37768
14
Adalimumab Approved Phase 3 331731-18-1 16219006
15 Coagulants Phase 3
16 Coagulase Phase 3
17 Antibodies, Monoclonal Phase 3
18 Antirheumatic Agents Phase 3
19 Anti-Inflammatory Agents Phase 3
20 methicillin Phase 2
21 CPG-oligonucleotide Phase 1
22 Adjuvants, Immunologic Phase 1
23
Lithium carbonate Approved Not Applicable 554-13-2
24
Heparin Approved, Investigational Not Applicable 9005-49-6 46507594 772
25
Haloperidol Approved 52-86-8 3559
26
Zolpidem Approved 82626-48-0 5732
27
Rocuronium Approved 119302-91-9, 143558-00-3 441290
28
Alfentanil Approved, Illicit 71195-58-9 51263
29
Ciprofloxacin Approved, Investigational 85721-33-1 2764
30
Piperacillin Approved 66258-76-2 43672
31
Warfarin Approved 81-81-2 54678486 6691
32
Cidofovir Approved 113852-37-2 60613
33
Aminocaproic Acid Approved, Investigational 60-32-2 564
34
Sevelamer Approved 52757-95-6
35
Oxycodone Approved, Illicit, Investigational 76-42-6 5284603
36
Cefepime Approved, Investigational 88040-23-7 5479537
37
Bosentan Approved, Investigational 147536-97-8 104865
38
Molindone Approved 7416-34-4 23897
39
Nafcillin Approved, Investigational 985-16-0, 147-52-4 8982
40
Labetalol Approved 36894-69-6 3869
41
Spironolactone Approved 1952-01-7, 52-01-7 5833
42
Nifedipine Approved 21829-25-4 4485
43
Methylprednisolone hemisuccinate Approved 2921-57-5
44
Ziprasidone Approved 146939-27-7 60854
45
Tranexamic Acid Approved 1197-18-8 5526
46
Pentobarbital Approved, Investigational, Vet_approved 76-74-4 4737
47
Prednisolone phosphate Approved, Vet_approved 302-25-0
48
Tobramycin Approved, Investigational 32986-56-4 36294 5496
49
Fosfomycin Approved 23155-02-4 446987
50
Tazobactam Approved 89786-04-9 123630

Interventional clinical trials:

(show all 30)
# Name Status NCT ID Phase Drugs
1 Efficacy of IgM Rich Immunoglobulin With Antibiotics for Bacterial Sepsis in Very Low Birth Weight Preterm Neonates Completed NCT03403530 Phase 4 IgM rich Immunoglobin
2 Procalcitonin-Guided Antimicrobial Discontinuation Completed NCT00250666 Phase 4
3 Non-specific Effects of Rabies Vaccine Enrolling by invitation NCT03656198 Phase 4 Sterile Water Injection
4 Neonatal Suspected Sepsis Treated With Cefazolin or Vancomycin Completed NCT01867138 Phase 3 Cefazolin;Vancomycin;Amikacin
5 Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease Completed NCT00195715 Phase 3
6 7 Days Versus 14 Days of Antibiotics for Neonatal Sepsis Not yet recruiting NCT03280147 Phase 3 7-day course of antibiotics;14-day course of antibiotics
7 Donor Human Milk in Young Children Receiving Bone Marrow Transplantation Completed NCT02470104 Phase 1, Phase 2
8 Human Breastmilk in Children Receiving a Bone Marrow Transplant Completed NCT02025478 Phase 1, Phase 2
9 Neonatal Vancomycin Trial Recruiting NCT02790996 Phase 2 Vancomycin
10 Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram-negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant Terminated NCT01164514 Phase 1 Placebo
11 Biomarkers for Feeding Intolerance in Infants With Complex Congenital Heart Defects Undergoing Single Ventricle Staged Palliation Unknown status NCT02995577
12 SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU Completed NCT01378169
13 Defects in Opsonophagocytosis in Premature Infants Completed NCT00866567
14 Impact of qSOFA Calculation on the Timing of Antimicrobial Therapy in the Emergency Department Completed NCT03299894 Not Applicable
15 Procalcitonin-Guided Decision Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis Completed NCT00926497 Not Applicable
16 Defining the Intestinal Microbiota in Premature Neonates Completed NCT01102738
17 Mechanisms of Inflammatory Liver Injury Completed NCT00011284
18 Defining Immunodeficiency in Heterotaxy Syndrome: Pilot Study Data Completed NCT01929967
19 Procalcitonin Levels in Patients With Fever and a Central Line Completed NCT01175005
20 Genotypes and Phenotypes in Pediatric SIRS and Sepsis Completed NCT02728401
21 Diagnostic Performance of a New Bio-marker During Bacterial Sepsis Recruiting NCT02721134 Not Applicable
22 Study of Low Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock Recruiting NCT03343041 Not Applicable
23 Quantification of Bacterial DNA in Sepsis Recruiting NCT03782454
24 Mortality Due to Septic Shock Associated With Thrombocytopenia Recruiting NCT03617965
25 Innate Lymphoid Cells in Septic Shock Recruiting NCT03297203 Not Applicable
26 NOBICS - NOvel BIomarker In Invasive CandidiasiS/Candida Sepsis Recruiting NCT02801682
27 Registry of Preterm Newborns With Severe Pulmonary Hypertension Recruiting NCT03310346
28 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Recruiting NCT01431326 The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
29 HostDx Sepsis in Patients With Acute Respiratory Infections Active, not recruiting NCT03744741
30 Characterization of the Inflammatory Profile of Patients With Macrophage Activation Syndrome Secondary to Bacterial Sepsis Not yet recruiting NCT03721809 Not Applicable

Search NIH Clinical Center for Bacterial Sepsis

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Genetic Tests for Bacterial Sepsis

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Anatomical Context for Bacterial Sepsis

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MalaCards organs/tissues related to Bacterial Sepsis:

42
Liver, Bone, Lung, Neutrophil, Bone Marrow, Heart, Prostate
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Publications for Bacterial Sepsis

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Articles related to Bacterial Sepsis:

(show top 50) (show all 270)
# Title Authors Year
1
Bacterial sepsis : Diagnostics and calculated antibiotic therapy. ( 29383395 )
2019
2
An ex vivo porcine spleen perfusion as a model of bacterial sepsis. ( 30076761 )
2019
3
Postmortem Intravascular Gas Caused by Antemortem Bacterial Sepsis. ( 30146599 )
2019
4
Calprotectin and calgranulin C serum levels in bacterial sepsis. ( 30420210 )
2019
5
Evaluation of Procalcitonin Accuracy for the Distinction Between Gram-Negative and Gram-Positive Bacterial Sepsis in Burn Patients. ( 30481299 )
2019
6
Bacterial sepsis triggers an antiviral response that causes translation shutdown. ( 30507610 )
2019
7
Nonhuman primate species as models of human bacterial sepsis. ( 30643274 )
2019
8
Gut Leakage of Fungal-Derived Inflammatory Mediators: Part of a Gut-Liver-Kidney Axis in Bacterial Sepsis. ( 30863955 )
2019
9
RE: Management of Neonates Born at ≤34 6/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. ( 31040194 )
2019
10
The impact of RAGE inhibition in animal models of bacterial sepsis: a systematic review and meta-analysis. ( 28760085 )
2018
11
Lactobacillus rhamnosus L34 Attenuates Gut Translocation-Induced Bacterial Sepsis in Murine Models of Leaky Gut. ( 29038123 )
2018
12
Fcµ Receptor Promotes the Survival and Activation of Marginal Zone B Cells and Protects Mice against Bacterial Sepsis. ( 29459869 )
2018
13
An Amperometric Biosensor for the Determination of Bacterial Sepsis Biomarker, Secretory Phospholipase Group 2-IIA Using a Tri-Enzyme System. ( 29495352 )
2018
14
Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters. ( 29537985 )
2018
15
Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice. ( 29563120 )
2018
16
Tamarixetin Exhibits Anti-inflammatory Activity and Prevents Bacterial Sepsis by Increasing IL-10 Production. ( 29851490 )
2018
17
Severe bacterial sepsis results in delayed diagnosis of tuberculous lymphadenitis in a rheumatoid arthritis patient treated with adalimumab. ( 29862158 )
2018
18
Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration. ( 29944697 )
2018
19
Bioluminescent murine models of bacterial sepsis and scald wound infections for antimicrobial efficacy testing. ( 30011298 )
2018
20
Continuous hemofiltration improves the prognosis of bacterial sepsis complicated by liver dysfunction in children. ( 30098593 )
2018
21
Gold nanoparticles attenuates bacterial sepsis in cecal ligation and puncture mouse model through the induction of M2 macrophage polarization. ( 30119646 )
2018
22
Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis. ( 30190719 )
2018
23
Anti-PF4/heparin antibodies are increased in hospitalized patients with bacterial sepsis. ( 30273811 )
2018
24
Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. ( 30455342 )
2018
25
Management of Neonates Born at ≤34 6/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. ( 30455344 )
2018
26
Viral Infections in Neonates with Suspected Late-Onset Bacterial Sepsis-A Prospective Cohort Study. ( 27182999 )
2017
27
Polarization of microglia and its role in bacterial sepsis. ( 28087076 )
2017
28
High Efficiency Binding Aptamers for a Wide Range of Bacterial Sepsis Agents. ( 28119514 )
2017
29
Bacterial sepsis, neutrophils and intracellular organisms. ( 28206662 )
2017
30
Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice. ( 28482922 )
2017
31
Bacterial sepsis in neonates: Single centre study in a Neonatal intensive care unit in Bosnia and Herzegovina. ( 28605923 )
2017
32
Diagnostic accuracy of procalcitonin, neutrophil-lymphocyte count ratio, C-reactive protein, and lactate in patients with suspected bacterial sepsis. ( 28727802 )
2017
33
Staphylococcus epidermidis: a major player in bacterial sepsis? ( 28748707 )
2017
34
Bacterial sepsis in the neonate. ( 28832421 )
2017
35
S1PR3 Signaling Drives Bacterial Killing and Is Required for Survival in Bacterial Sepsis. ( 28850247 )
2017
36
The Role of S1PR3 in Protection from Bacterial Sepsis. ( 28910137 )
2017
37
The Importance of Mean Neutrophil Volume (MNV) Values in Differential Diagnosis of Bacterial Sepsis. ( 28987251 )
2017
38
Scutellarin Suppresses NLRP3 Inflammasome Activation in Macrophages and Protects Mice against Bacterial Sepsis. ( 29375379 )
2017
39
Management of term infants at increased risk for early-onset bacterial sepsis. ( 29480905 )
2017
40
Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study. ( 30169202 )
2017
41
THE ROLE OF PROCALCITONIN AS A DIAGNOSTIC MARKER OF BACTERIAL SEPSIS IN BURNS. ( 28876695 )
2017
42
Bacterial Sepsis Increases Survival in Metastatic Melanoma: Chlamydophila Pneumoniae Induces Macrophage Polarization and Tumor Regression. ( 26743601 )
2016
43
Multiplex cytokine analyses in dogs with pyometra suggest involvement of KC-like chemokine in canine bacterial sepsis. ( 26837616 )
2016
44
Interleukin-6 Kinetics can be Useful for Early Treatment Monitoring of Severe Bacterial Sepsis and Septic Shock. ( 27103972 )
2016
45
Etiologic Agents of Bacterial Sepsis and Their Antibiotic Susceptibility Patterns among Patients Living with Human Immunodeficiency Virus at Gondar University Teaching Hospital, Northwest Ethiopia. ( 27314025 )
2016
46
Serum procalcitonin levels distinguish Gram-negative bacterial sepsis from Gram-positive bacterial and fungal sepsis. ( 27904585 )
2016
47
Etiological profile of early neonatal bacterial sepsis by multiplex qPCR. ( 28036311 )
2016
48
Procalcitonin as a rapid diagnostic biomarker to differentiate between culture-negative bacterial sepsis and systemic inflammatory response syndrome: a prospective, observational, cohort study. ( 25263339 )
2015
49
CD28 homodimer interface mimetic peptide acts as a preventive and therapeutic agent in models of severe bacterial sepsis and gram-negative bacterial peritonitis. ( 25305323 )
2015
50
Expression profile of MicroRNAs in gram-negative bacterial sepsis. ( 25394245 )
2015
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Variations for Bacterial Sepsis

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Expression for Bacterial Sepsis

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Search GEO for disease gene expression data for Bacterial Sepsis.
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Pathways for Bacterial Sepsis

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Pathways related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.88 CD14 CRP CXCL8 ELANE IL10 LBP
2
Toll-like Receptor Signaling Pathway 1 38
Show member pathways
 12.97 CD14 CXCL8 IL10 LBP NOS2 TLR4
3
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 67
Show member pathways
 12.64 CD14 CXCL8 TLR4 TNF
4
TRAF Pathway 65
Show member pathways
 12.5 CD14 LBP TLR4 TNF
5
Immune response IL-23 signaling pathway 23
Show member pathways
 12.48 CD14 IL10 NOS2 TNF
6
Toll Comparative Pathway 65
Show member pathways
 12.21 CD14 CXCL8 LBP NOS2 TLR4 TNF
7
Diseases associated with the TLR signaling cascade 67
Show member pathways
 12.18 CD14 CXCL8 TLR4 TNF
8
Toxoplasmosis 38
Show member pathways
 12.16 IL10 NOS2 TLR4 TNF
9
IL-1 Family Signaling Pathways 66
Show member pathways
 12.11 CXCL8 NOS2 TNF
10
Colorectal Cancer Metastasis 65
12.07 NOS2 TLR4 TNF
11
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.06 CXCL8 IL10 TNF
12
Tuberculosis 38
12.05 CD14 IL10 LBP NOS2 TLR4 TNF
13
Th1 Differentiation Pathway 66
Show member pathways
 11.96 IL10 TLR4 TNF
14
Spinal Cord Injury 1
11.96 CXCL8 NOS2 TLR4 TNF
15
Bacterial infections in CF airways 23
Show member pathways
 11.95 CD14 CXCL8 LBP NOS2 TLR4 TNF
16
Microglia Activation During Neuroinflammation: Overview 66
Show member pathways
 11.94 CD14 TLR4 TNF
17
Interleukin-4 and 13 signaling 67
11.91 CXCL8 IL10 LBP NOS2 TNF
18
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.9 CD14 IL10 TNF
19
Cytokine production by Th17 cells in CF (Mouse model) 23
Show member pathways
 11.83 CD14 CXCL8 LBP TLR4
20
AGE-RAGE signaling pathway in diabetic complications 38
11.82 CXCL8 SELE TNF
21
NF-kappa B signaling pathway 38
11.8 CD14 CXCL8 LBP TLR4 TNF
22
Rheumatoid arthritis 38
11.78 CXCL8 TLR4 TNF
23
NF-kB (NFkB) Pathway 68
11.71 CD14 LBP TLR4 TNF
24
Salmonella infection (KEGG) 38
11.7 CD14 CXCL8 LBP NOS2 TLR4
25
Dendritic Cells Developmental Lineage Pathway 66
11.68 CD14 IL10 TNF
26
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.66 IL10 NOS2 TNF
27
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.64 CXCL8 NOS2 SELE TNF
28
Lung fibrosis 1
11.6 CALCA CXCL8 TNF
29
Legionellosis 38
11.57 CD14 CXCL8 TLR4 TNF
30
Transcription_NF-kB signaling pathway 23
11.54 CD14 LBP TLR4 TNF
31
ATF-2 transcription factor network 1
11.53 CXCL8 NOS2 SELE
32
Interleukin-10 signaling 67
11.48 CXCL8 IL10 TNF
33
MSP-RON Signaling 65
11.46 NOS2 TLR4 TNF
34
Amoebiasis 38
11.42 CD14 CXCL8 IL10 NOS2 TLR4 TNF
35
African trypanosomiasis 38
11.33 IL10 SELE TNF
36
IL-10 Pathway 65
11.32 CD14 IL10 TLR4 TNF
37
Malaria 38
11.24 CXCL8 IL10 SELE TLR4 TNF
38
EBV LMP1 signaling 1
11.06 CXCL8 TNF
39
IKK complex recruitment mediated by RIP1 67
11.06 CD14 TLR4
40
Overview of nanoparticle effects 1
11.02 CRP CXCL8 TNF
41
Pertussis 38
10.98 CD14 CXCL8 IL10 NOS2 TLR4 TNF
42
MIF Action Through Endocytic Pathway 65
10.73 CD14 TLR4
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GO Terms for Bacterial Sepsis

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Cellular components related to Bacterial Sepsis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 CD14 ELANE LBP TLR4 TNF
2 extracellular region GO:0005576 9.61 CALCA CD14 CRP CXCL8 ELANE IL10
3 cortical cytoskeleton GO:0030863 9.32 NOS2 SELE
4 extracellular space GO:0005615 9.28 CALCA CD14 CRP CXCL8 ELANE IL10
5 lipopolysaccharide receptor complex GO:0046696 9.16 CD14 TLR4

Biological processes related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.99 CALCA CXCL8 IL10 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.93 CXCL8 IL10 LBP NOS2 TNF
3 response to bacterium GO:0009617 9.85 CD14 NOS2 TLR4
4 defense response to bacterium GO:0042742 9.85 ELANE IL10 LBP NOS2 TLR4 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.84 CRP LBP TNF
6 defense response to Gram-negative bacterium GO:0050829 9.84 LBP NOS2 TLR4
7 regulation of inflammatory response GO:0050727 9.81 SELE TLR4 TNF
8 apoptotic signaling pathway GO:0097190 9.8 CD14 TLR4 TNF
9 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.79 CD14 TLR4 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.79 LBP TLR4 TNF
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 CD14 TLR4 TNF
12 positive regulation of tumor necrosis factor production GO:0032760 9.77 CD14 LBP TLR4
13 negative regulation of tumor necrosis factor production GO:0032720 9.77 IL10 LBP TLR4
14 positive regulation of interferon-gamma production GO:0032729 9.76 CD14 TLR4 TNF
15 toll-like receptor signaling pathway GO:0002224 9.74 CD14 LBP TLR4
16 negative regulation of interleukin-6 production GO:0032715 9.73 IL10 TLR4 TNF
17 positive regulation of cytokine secretion GO:0050715 9.72 CD14 IL10 TNF
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 CD14 LBP TLR4 TNF
19 leukocyte chemotaxis GO:0030595 9.7 CXCL8 IL10
20 negative regulation of osteoclast differentiation GO:0045671 9.7 CALCA TLR4
21 positive regulation of neutrophil chemotaxis GO:0090023 9.7 CXCL8 LBP
22 positive regulation of chemokine production GO:0032722 9.7 LBP TLR4 TNF
23 response to lipopolysaccharide GO:0032496 9.7 CD14 ELANE IL10 LBP NOS2 SELE
24 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.69 CD14 TLR4
25 necroptotic process GO:0070266 9.69 CD14 TLR4
26 positive regulation of macrophage activation GO:0043032 9.69 IL10 LBP TLR4
27 embryonic digestive tract development GO:0048566 9.68 CXCL8 TNF
28 leukocyte tethering or rolling GO:0050901 9.68 SELE TNF
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL10 TNF
30 MyD88-independent toll-like receptor signaling pathway GO:0002756 9.67 CD14 TLR4
31 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.67 LBP TLR4
32 toll-like receptor 4 signaling pathway GO:0034142 9.67 CD14 LBP TLR4
33 leukocyte migration involved in inflammatory response GO:0002523 9.66 ELANE SELE
34 negative regulation of lipid storage GO:0010888 9.65 CRP TNF
35 opsonization GO:0008228 9.65 CRP LBP
36 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
37 response to molecule of bacterial origin GO:0002237 9.65 CD14 CXCL8 IL10
38 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.64 CD14 TLR4
39 positive regulation of MHC class II biosynthetic process GO:0045348 9.64 IL10 TLR4
40 negative regulation of cytokine secretion involved in immune response GO:0002740 9.63 IL10 TNF
41 cellular response to lipoteichoic acid GO:0071223 9.63 CD14 LBP TLR4
42 positive regulation of interleukin-8 production GO:0032757 9.62 CALCA LBP TLR4 TNF
43 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 ELANE TLR4 TNF
44 receptor biosynthetic process GO:0032800 9.58 IL10 TNF
45 negative regulation of growth of symbiont in host GO:0044130 9.56 ELANE IL10 LBP TNF
46 cellular response to lipopolysaccharide GO:0071222 9.5 CD14 CXCL8 IL10 LBP NOS2 TLR4
47 inflammatory response GO:0006954 9.23 CD14 CRP CXCL8 IL10 S1PR3 SELE
48 innate immune response GO:0045087 10.01 CD14 CRP LBP TLR4
49 immune response GO:0006955 10 CXCL8 IL10 TLR4 TNF

Molecular functions related to Bacterial Sepsis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CALCA CD14 CRP CXCL8 ELANE IL10
2 signaling receptor binding GO:0005102 9.62 CALCA LBP NOS2 TLR4
3 lipopeptide binding GO:0071723 9.26 CD14 LBP
4 lipoteichoic acid binding GO:0070891 8.96 CD14 LBP
5 lipopolysaccharide binding GO:0001530 8.8 CD14 LBP TLR4
Sources

Sources for Bacterial Sepsis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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