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MCID: BCT021
MIFTS: 44

Bacterial Sepsis

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bacterial Sepsis

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MalaCards integrated aliases for Bacterial Sepsis:

Name: Bacterial Sepsis 12 15

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0040085
ICD9CM 34 995.91
SNOMED-CT 67 17463016
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Summaries for Bacterial Sepsis

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Disease Ontology : 12 A bacterial infectious disease has material basis in Bacteria.

MalaCards based summary : Bacterial Sepsis is related to sepsis in premature infants and disseminated intravascular coagulation. An important gene associated with Bacterial Sepsis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs leucovorin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include liver, neutrophil and lung, and related phenotypes are cardiovascular system and hematopoietic system

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Related Diseases for Bacterial Sepsis

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Diseases related to Bacterial Sepsis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 496)
# Related Disease Score Top Affiliating Genes
1 sepsis in premature infants 32.4 CRP CALCA
2 disseminated intravascular coagulation 30.5 TNF SELE IL10 ELANE CRP
3 candidiasis 30.5 TNF TLR4 IL10 CXCL8
4 haemophilus influenzae 30.4 TNF CXCL8
5 shwartzman phenomenon 30.4 VCAM1 TNF SELE
6 smallpox 30.3 TNF IL1RN IL18
7 septic arthritis 30.3 TLR4 CXCL8 CRP CALCA
8 bacterial meningitis 30.3 TNF TLR4 IL18 IL10 CXCL8 CRP
9 purpura 30.3 TNF IL10 CRP
10 bacteriuria 30.3 TLR4 IL18 CXCL8 CRP
11 bronchopulmonary dysplasia 30.2 IL1RN ELANE CXCL8
12 perinatal necrotizing enterocolitis 30.2 TNF TLR4 IL10 CXCL8 CRP CCR6
13 toxoplasmosis 30.2 TNF TLR4 NOS2 IL10
14 extrapulmonary tuberculosis 30.2 TNF IL1RN IL10 CRP
15 cholangitis 30.1 TNF TLR4 IL10 CXCL8 CRP
16 osteomyelitis 30.1 TNF TLR4 IL1RN IL10 CXCL8 CALCA
17 diarrhea 30.1 TNF TLR4 IL10 CXCL8 CALCA
18 exudative vitreoretinopathy 1 30.1 TNF CXCL8 CRP
19 meningoencephalitis 30.1 TNF IL10 CRP CCR6
20 cellulitis 30.1 TNF IL10 CRP CCR6
21 glomerulonephritis 29.9 VCAM1 NOS2 MIF ELANE
22 meningitis 29.9 TNF TLR4 LBP IL18 IL10 CXCL8
23 liver cirrhosis 29.9 TNF LBP IL10 CRP CD14
24 otitis media 29.9 TNF TLR4 IL10 ELANE CXCL8 CRP
25 toxic shock syndrome 29.9 TNF TLR4 NOS2 MIF LBP IL1RN
26 allergic hypersensitivity disease 29.9 TNF TLR4 IL10 CXCL8 CCR6
27 exanthem 29.9 TNF IL1RN IL10 CXCL8 CRP CCR6
28 gastroenteritis 29.9 TNF IL1RN IL10 CXCL8 CRP CALCA
29 myocarditis 29.8 VCAM1 TNF TLR4 NOS2 IL18 IL10
30 plasmodium falciparum malaria 29.8 TNF SELE NOS2 MIF IL18 IL10
31 visceral leishmaniasis 29.7 TNF TLR4 NOS2 IL18 IL10 CXCL8
32 leishmaniasis 29.7 TNF TLR4 NOS2 IL18 IL10 CXCL8
33 cystic fibrosis 29.7 TNF TLR4 IL10 ELANE CXCL8
34 acquired immunodeficiency syndrome 29.7 VCAM1 TNF SELE NOS2 IL10 CRP
35 acute cystitis 29.6 TNF TLR4 IL18 IL10 CXCL8 CRP
36 lymphadenitis 29.6 TNF TLR4 IL18 IL10 CXCL8 CRP
37 peritonitis 29.5 TNF TLR4 NOS2 LBP IL18 IL10
38 myeloma, multiple 29.5 VCAM1 TNF TLR4 IL10 CXCL8 CRP
39 thrombocytopenia 29.4 TNF TLR4 SELE PF4 IL1RN IL18
40 respiratory failure 29.4 TNF PF4 IL1RN IL10 ELANE CXCL8
41 bacterial infectious disease 29.1 TNF TLR4 MIF LBP IL1RN IL18
42 malaria 28.1 VCAM1 TNF TLR4 SELE PF4 NOS2
43 punctate inner choroidopathy 10.7 TNF IL10
44 tropical endomyocardial fibrosis 10.6 TNF IL10
45 drug reaction with eosinophilia and systemic symptoms 10.6 TNF CRP
46 multifocal choroiditis 10.6 TNF IL10
47 idiopathic anterior uveitis 10.6 TNF CXCL8
48 prosthetic joint infection 10.6 TLR4 CRP
49 conjunctivitis 10.6 TNF IL10 CXCL8
50 thyroiditis 10.6 TNF IL10 CALCA

Graphical network of the top 20 diseases related to Bacterial Sepsis:



Diseases related to Bacterial Sepsis
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Symptoms & Phenotypes for Bacterial Sepsis

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MGI Mouse Phenotypes related to Bacterial Sepsis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 CCR6 CRP IL10 IL18 IL1RN NOS2
2 hematopoietic system MP:0005397 10.03 CCR6 CD14 ELANE IL10 IL18 IL1RN
3 homeostasis/metabolism MP:0005376 9.86 CCR6 CD14 CRP ELANE IL10 IL18
4 immune system MP:0005387 9.53 CCR6 CD14 CRP ELANE IL10 IL18
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Drugs & Therapeutics for Bacterial Sepsis

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Drugs for Bacterial Sepsis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 6006 143
2
Sulfamethoxazole Approved Phase 4 723-46-6 5329
3
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
4
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
5
Glycine Approved, Nutraceutical, Vet_approved Phase 4 56-40-6 750
6 Anti-Infective Agents Phase 4
7 Anti-Bacterial Agents Phase 4
8 Immunoglobulin A Phase 4
9 Folic Acid Antagonists Phase 4
10 Renal Agents Phase 4
11 Vitamin B Complex Phase 4
12 Cytochrome P-450 Enzyme Inhibitors Phase 4
13 Anti-Retroviral Agents Phase 4
14 Vitamin B9 Phase 4
15 Antimalarials Phase 4
16 Folate Phase 4
17 Antiparasitic Agents Phase 4
18 Anti-Infective Agents, Urinary Phase 4
19 Antiprotozoal Agents Phase 4
20 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
21 Vaccines Phase 4
22
Vancomycin Approved Phase 3 1404-90-6 441141 14969
23
Amikacin Approved, Investigational, Vet_approved Phase 3 37517-28-5 37768
24
Cefazolin Approved Phase 3 25953-19-9 33255 656510
25 Coagulants Phase 3
26 Coagulase Phase 3
27 Antibiotics, Antitubercular Phase 3
28 Antibodies Phase 2, Phase 3
29 Immunoglobulins Phase 2, Phase 3
30 Antitubercular Agents Phase 3
31 Immunologic Factors Phase 2, Phase 3
32 Antibodies, Monoclonal Phase 2, Phase 3
33 Pharmaceutical Solutions Phase 2, Phase 3
34 methicillin Phase 2
35
Methylprednisolone Approved, Vet_approved Phase 1 83-43-2 6741
36
Methylprednisolone hemisuccinate Approved Phase 1 2921-57-5
37 Prednisolone acetate Approved, Vet_approved Phase 1 52-21-1
38
Prednisolone Approved, Vet_approved Phase 1 50-24-8 5755
39
Prednisolone phosphate Approved, Vet_approved Phase 1 302-25-0
40
Prednisolone hemisuccinate Experimental Phase 1 2920-86-7
41 Protective Agents Phase 1
42 Antiemetics Phase 1
43 Anti-Inflammatory Agents Phase 1
44 Gastrointestinal Agents Phase 1
45 Methylprednisolone Acetate Phase 1
46 Neuroprotective Agents Phase 1
47 glucocorticoids Phase 1
48 Antineoplastic Agents, Hormonal Phase 1
49 Hormone Antagonists Phase 1
50 Autonomic Agents Phase 1

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 A Prospective Study to Analyze the Efficacy of IgM Rich Immunoglobulin as an Adjunct to Antibiotics in the Treatment of Bacterial Sepsis in Very Low Birth Weight Preterm Neonates Completed NCT03403530 Phase 4 IgM rich Immunoglobin
2 Procalcitonin-Guided Antimicrobial Discontinuation Strategy in Critically Ill Patients With Suspected or Confirmed Bacterial Sepsis Completed NCT00250666 Phase 4
3 Randomized Clinical Trial to Assess Whether the Duration of Cotrimoxazole Preventive Therapy in HIV Patients With CD4 Counts >350 CD4 Cells/µL by Antiretroviral Treatment Influences the Rate of Carriage of Multidrug-resistant Bacteria Completed NCT03087890 Phase 4 Cotrimoxazole;Placebo
4 Non-specific Effects of Rabies Vaccine on the Incidence of Common Infectious Disease Episodes: a Randomized Controlled Trial Enrolling by invitation NCT03656198 Phase 4 Sterile Water Injection
5 Clinical Outcome of Newborn Infants With Suspected Nosocomial Coagulase-negative Staphylococcal Sepsis Treated With Cefazolin or Vancomycin. A Non-inferiority, Randomized, Controlled Trial Completed NCT01867138 Phase 3 Cefazolin;Vancomycin;Amikacin
6 Comparison of the Efficacy of a 7-day Versus 14-day Course of Intravenous Antibiotics in the Treatment of Uncomplicated Neonatal Bacterial Sepsis: a Randomized Controlled Non-inferiority Trial Not yet recruiting NCT03280147 Phase 3 7-day course of antibiotics;14-day course of antibiotics
7 PCSK9 Inhibitor: a New Tool to Fight Septic Shock Not yet recruiting NCT03634293 Phase 2, Phase 3 Alirocumab Injectable Product;Saline Solution
8 Multi-centre, Randomised, Open Label, Phase IIb Study to Compare the Efficacy, Safety and Pharmacokinetics (PK) of an Optimised Dosing to a Standard Dosing Regimen of Vancomycin in Neonates and Infants Aged ≤ 90 Days With Late Onset Bacterial Sepsis Known or Suspected to be Caused by Gram-positive Microorganisms Recruiting NCT02790996 Phase 2 Vancomycin
9 Randomized Placebo Controlled Trial of Subcutaneous rhIL-1A (Anakinra) in the Management of Hospitalized Pediatric and Adult Patients With Macrophage Activation Syndrome Recruiting NCT02780583 Phase 1 kineret;placebo
10 A Randomized, Partial-Blinded, Placebo-Controlled, Phase I Safety and Immunogenicity Study in Healthy Subjects of Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram Negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant Terminated NCT01164514 Phase 1 Placebo
11 Complications of Exchange Transfusion in Neonates Unknown status NCT03195049
12 Role of Innate Lymphoid Cells in the Immunosuppression of Septic Shock Unknown status NCT03297203
13 Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients Unknown status NCT01482988
14 Newborn Infection Control and Care Initiative for Health Facilities to Accelerate Reduction of Newborn Mortality Unknown status NCT02271737
15 Usefulness of Routine qSOFA Calculation at Triage to Fasten Antimicrobial Administration in Patients With Bacterial Infection in the Emergency Department: a Quasi-experimental Study Completed NCT03299894
16 Prospective Evaluation of Serum Procalcitonin in Critically Ill Patients With Suspected Sepsis- Experience From a Tertiary Care Hospital in Pakistan Completed NCT03506152
17 Use of Procalcitonin-Guided Decision Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis: Prospective Randomized Intervention Trial Completed NCT00926497
18 Defects in Opsonophagocytosis in Premature Infants as a Factor for the Development of Neonatal Sepsis Completed NCT00866567
19 Mechanisms of Inflammatory Liver Injury Completed NCT00011284
20 The Effects of an Endotoxin Challenge on the Immune Response Elicited by a Subsequent Challenge With Fluenz in Healthy Volunteers, an Explorative Study Completed NCT02642237
21 Defining Immunodeficiency in Heterotaxy Syndrome: Pilot Study Data Completed NCT01929967
22 Genotypes and Phenotypes in Pediatric SIRS and Sepsis (GAPPSS) Completed NCT02728401
23 Low Dose Parenteral Fat for Prevention of Parenteral Nutrition Associated Cholestasis in Preterm Neonates Completed NCT01050660
24 Investigation of Inflammatory Parameters in a Perioperative Closed-meshed Standard Progress in CPB Patients Completed NCT02963480
25 Early Detection and Diagnostic Performance of Bio-markers During Bacterial Sepsis: Multicentre Cohort Study in Intensive Care Completed NCT01378169
26 The Efficacy of Neurophysiologically Based Occupational Therapy Intervention in the Neonatal Intensive Care Unit: An Exploratory Study Completed NCT00766051
27 Pilot Study of Low-Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock Recruiting NCT03343041
28 Diagnostic Performance of a New Bio-marker During Bacterial Sepsis Recruiting NCT02721134
29 An Audit Study on Management of Neonates With Neonatal Sepsis Admitted to Asyut University Children Hospital Recruiting NCT03634891
30 Measurement of the Recovery and Lifespan of Red Blood Cells From Pathogen-Reduced, Stored Blood Units Using Cellular Biotinylation Recruiting NCT03384407
31 Characterization of the Inflammatory Profile of Patients With Macrophage Activation Syndrome Secondary to Bacterial Sepsis Not yet recruiting NCT03721809
32 Neutrophil FFA2/GPR43 Receptor Expression in Patients With the Diagnosis of Sepsis Withdrawn NCT02699905

Search NIH Clinical Center for Bacterial Sepsis

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Genetic Tests for Bacterial Sepsis

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Anatomical Context for Bacterial Sepsis

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MalaCards organs/tissues related to Bacterial Sepsis:

40
Liver, Neutrophil, Lung, Bone, T Cells, Kidney, Endothelial
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Publications for Bacterial Sepsis

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Articles related to Bacterial Sepsis:

(show top 50) (show all 1527)
# Title Authors PMID Year
1
Procalcitonin and Bacterial Sepsis in Burn Patients in South Africa. 61
31635838 2020
2
Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria. 61
31693729 2020
3
The Role of Serum Procalcitonin in Predicting Bacterial Sepsis in Patients With Hypothyroidism. 61
31361312 2019
4
Infection profile in children and adolescents with bone marrow failures treated with allogeneic hematopoietic stem cell transplantation. 61
31587440 2019
5
Elevated levels of interleukin-27 in early life compromise protective immunity in a mouse model of Gram-negative neonatal sepsis. 61
31818960 2019
6
Splenic Innate B1 B Cell Plasmablasts Produce Sustained Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Cytokines during Murine Malaria Infections. 61
31591168 2019
7
Effect of O antigen ligase gene mutation on oxidative stress resistance and pathogenicity of NMEC strain RS218. 61
31400443 2019
8
Etiologies of Thrombocytopenia in the Community Hospital: the Experience of One Hematologist. 61
31712096 2019
9
Isorhamnetin Has Potential for the Treatment of Escherichia coli-Induced Sepsis. 61
31689976 2019
10
Toll-like receptor bioactivity in endothelial progenitor cells. 61
31754781 2019
11
Peritoneal GATA6+ macrophages function as a portal for Staphylococcus aureus dissemination. 61
31545300 2019
12
Perinatal outcome in women with bacterial sepsis: A cross-sectional study from West China. 61
31689830 2019
13
Diagnosis of bacterial sepsis: why are tests for bacteremia not sufficient? 61
31446810 2019
14
Platelet Proteasome Activity and Metabolism Is Upregulated during Bacterial Sepsis. 61
31783490 2019
15
Atmospheric pressure non-thermal plasma exposure reduces Pseudomonas aeruginosa lipopolysaccharide toxicity in vitro and in vivo. 61
31437578 2019
16
Transfer of Hexon- and Penton-selected adenovirus-specific T cells for refractory adenovirus infection after haploidentical stem cell transplantation. 61
31643129 2019
17
Cumulative evidence for association of sepsis and retinopathy of prematurity. 61
31626109 2019
18
IL-10-producing regulatory B cells exhibit functional defects and play a protective role in severe endotoxic shock. 61
31536782 2019
19
Enteroviral infection in neonates. 61
31607572 2019
20
Gut Leakage of Fungal-Derived Inflammatory Mediators: Part of a Gut-Liver-Kidney Axis in Bacterial Sepsis. 61
30863955 2019
21
Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung. 61
31268348 2019
22
Assessment of novel biomarkers: sTREM-1, pentraxin-3 and pro-adrenomedullin in the early diagnosis of neonatal early onset sepsis. 61
31594258 2019
23
Drug repositioning of TANK-binding kinase 1 inhibitor CYT387 as an alternative for the treatment of Gram-negative bacterial sepsis. 61
31173970 2019
24
Investigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies. 61
31442221 2019
25
Nitrofurantoin-associated Acute Pulmonary Toxicity Mimicking Severe Sepsis with Significantly Elevated Procalcitonin. 61
31687292 2019
26
An Audit on Overnight Transfusion Practice in A Teaching Hospital in Malaysia. 61
31427551 2019
27
Neonatal Group B Streptococcal Infection in a Tertiary Care Hospital in Saudi Arabia: A 13-year Experience. 61
31192978 2019
28
Central nervous system diseases of cattle in Georgia, 2001-2017. 61
31179896 2019
29
Allograft of Primary Cutaneous Mucormycosis in a Preterm Neonate: A Case Report. 61
31373557 2019
30
The contact system proteases play disparate roles in streptococcal sepsis. 61
31320552 2019
31
Rapid diagnosis of Capnocytophaga canimorsus septic shock in an immunocompetent individual using real-time Nanopore sequencing: a case report. 61
31340776 2019
32
Blockade of PD-1 Attenuated Post-Sepsis Aspergillosis via The Activation Of IFN-γ and The Dampening of IL-10. 61
31306346 2019
33
Influenza virus-related critical illness: pathophysiology and epidemiology. 61
31324202 2019
34
Severe Sepsis in Pediatric Liver Transplant Patients: The Emergence of Multidrug-Resistant Organisms. 61
31094887 2019
35
Toll-like Receptor 7 Contributes to Inflammation, Organ Injury, and Mortality in Murine Sepsis. 61
31045897 2019
36
PROCalcitonin-based algorithm for antibiotic use in Acute Pancreatitis (PROCAP): study protocol for a randomised controlled trial. 61
31358032 2019
37
A Single Institution's Experience with Cytogenetic and MRD Outcomes in Pediatric Acute Lymphoblastic Leukemia. 61
31133155 2019
38
Design and Synthesis of Biocompatible, Hemocompatible, and Highly Selective Antimicrobial Cationic Peptidopolysaccharides via Click Chemistry. 61
31070896 2019
39
Reactivation of Cytomegalovirus Increases Nitric Oxide and IL-10 Levels in Sepsis and is Associated with Changes in Renal Parameters and Worse Clinical Outcome. 61
31227794 2019
40
Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: a systematic review and meta-analysis. 61
31159729 2019
41
Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis. 61
31209224 2019
42
Candida/Staphylococcal Polymicrobial Intra-Abdominal Infection: Pathogenesis and Perspectives for a Novel Form of Trained Innate Immunity. 61
31075836 2019
43
Procalcitonin as a diagnostic biomarker of sepsis: A tertiary care centre experience. 61
30497960 2019
44
Resistin directly inhibits bacterial killing in neutrophils. 61
31147868 2019
45
RE: Management of Neonates Born at ≤34 6/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. 61
31040194 2019
46
Impact of Partnership Between Children's HeartLink and IQIC Database With a Pediatric Cardiology and Cardiovascular Surgery Center in Brazil. 61
31084314 2019
47
Murine myeloid-derived suppressor cells are a source of elevated levels of interleukin-27 in early life and compromise control of bacterial infection. 61
30575117 2019
48
Minimal adjuvant chemotherapy for children with hepatoblastoma resected at diagnosis (AHEP0731): a Children's Oncology Group, multicentre, phase 3 trial. 61
30975630 2019
49
Juvenile ecthyma gangrenosum caused by Pseudomonas aeruginosa revealing an underlying neutropenia: case report and review of the literature. 61
30633375 2019
50
Microbiological Screening of Platelet Concentrates in Europe. 61
31191193 2019
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Variations for Bacterial Sepsis

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Expression for Bacterial Sepsis

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Search GEO for disease gene expression data for Bacterial Sepsis.
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Pathways for Bacterial Sepsis

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Pathways related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.03 VCAM1 TNF TLR4 PTAFR NOS2 MIF
2
PEDF Induced Signaling 63
Show member pathways
 13.69 TNF TLR4 PF4 NOS2 MIF IL1RN
3
Akt Signaling 63
Show member pathways
 13.43 TNF TLR4 PF4 IL18 IL10 CXCL8
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.39 VCAM1 TNF PTAFR NOS2 LBP IL1RN
5
PAK Pathway 63
Show member pathways
 13.31 TNF PF4 IL18 IL10 CXCL8 CXCL5
6
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.16 TNF TLR4 NOS2 LBP IL18 IL10
7
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.77 TNF TLR4 IL18 CXCL8 CD14
8
Immune response IL-23 signaling pathway 22
Show member pathways
 12.61 TNF NOS2 IL18 IL10 CD14
9
Shigellosis 36
12.43 TNF TLR4 IL18 CXCL8 CD14
10
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.37 TNF PF4 IL18 IL10 CXCL8 CXCL5
11
Toll Comparative Pathway 63
Show member pathways
 12.35 TNF TLR4 NOS2 MIF LBP CXCL8
12
Pathogenic Escherichia coli infection 36
12.3 TNF TLR4 IL18 CXCL8
13
IL-1 Family Signaling Pathways 64
Show member pathways
 12.28 TNF NOS2 IL1RN IL18 CXCL8
14
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.27 TNF TLR4 CXCL8 CD14
15
Toxoplasmosis 36
Show member pathways
 12.27 TNF TLR4 NOS2 IL10
16
NOD-like receptor signaling pathway 36
12.25 TNF TLR4 IL18 CXCL8
17
Bacterial infections in CF airways 22
Show member pathways
 12.24 TNF TLR4 NOS2 LBP CXCL8 CD14
18
Tuberculosis 36
12.2 TNF TLR4 NOS2 LBP IL18 IL10
19
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.19 TNF IL1RN IL10 CXCL8
20
Th1 Differentiation Pathway 64
Show member pathways
 12.08 TNF TLR4 IL18 IL10
21
Yersinia infection 36
12.08 TNF TLR4 IL18 IL10 CXCL8
22
Spinal Cord Injury 1
12.07 TNF TLR4 NOS2 MIF CXCL8
23
TNF signaling pathway 36
12.02 VCAM1 TNF SELE CXCL5
24
AGE-RAGE signaling pathway in diabetic complications 36
11.96 VCAM1 TNF SELE CXCL8
25
NF-kappa B signaling pathway 36
11.96 VCAM1 TNF TLR4 LBP CXCL8 CD14
26
Amoebiasis 36
11.94 TNF TLR4 NOS2 IL10 CXCL8 CD14
27
Rheumatoid arthritis 36
11.93 TNF TLR4 IL18 CXCL8 CXCL5
28
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.92 TLR4 LBP CXCL8 CD14
29
Interleukin-4 and 13 signaling 65
11.86 VCAM1 TNF NOS2 LBP IL18 IL10
30
Innate Lymphoid Cell Differentiation Pathways 64
11.85 TNF IL18 IL10 CCR6
31
NF-kB (NFkB) Pathway 66
11.8 TNF TLR4 LBP CD14
32
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.79 TNF NOS2 IL1RN IL18 IL10
33
Dendritic Cells Developmental Lineage Pathway 64
11.75 TNF IL10 CD14
34
Salmonella infection (KEGG) 36
11.75 TLR4 NOS2 LBP IL18 CXCL8 CD14
35
Legionellosis 36
11.68 TNF TLR4 IL18 CXCL8 CD14
36
Lung fibrosis 1
11.67 TNF CXCL8 CALCA
37
Transcription_NF-kB signaling pathway 22
11.64 TNF TLR4 LBP CD14
38
ATF-2 transcription factor network 1
11.6 SELE NOS2 CXCL8
39
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 VCAM1 TNF SELE NOS2 MIF CXCL8
40
MSP-RON Signaling 63
11.59 TNF TLR4 NOS2 IL18
41
IL-10 Pathway 63
11.43 TNF TLR4 IL10 CD14
42
African trypanosomiasis 36
11.4 VCAM1 TNF SELE IL18 IL10
43
Pertussis 36
11.38 TNF TLR4 NOS2 IL10 CXCL8 CXCL5
44
Interleukin-10 signaling 65
11.32 TNF PTAFR IL1RN IL18 IL10 CXCL8
45
Cellular roles of Anthrax toxin 1
11.17 VCAM1 TNF IL18
46
Overview of nanoparticle effects 1
11.1 TNF CXCL8 CRP
47
G-protein signaling_Rap2B regulation pathway 22
11.05 TNF PF4 IL18 IL10 CXCL8 CXCL5
48
MIF Action Through Endocytic Pathway 63
10.87 TLR4 MIF CD14
49
Malaria 36
10.87 VCAM1 TNF TLR4 SELE IL18 IL10
Sources

GO Terms for Bacterial Sepsis

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Cellular components related to Bacterial Sepsis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNF S1PR3 PF4 MIF LBP IL1RN
2 cell surface GO:0009986 9.76 VCAM1 TNF TLR4 MIF LBP ELANE
3 external side of plasma membrane GO:0009897 9.72 VCAM1 TNF TLR4 CD14 CCR6
4 extracellular space GO:0005615 9.5 VCAM1 TNF SELE PF4 MIF LBP
5 lipopolysaccharide receptor complex GO:0046696 9.26 TLR4 CD14

Biological processes related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.32 TLR4 S1PR3 PTAFR IL1RN IL18 IL10
2 G protein-coupled receptor signaling pathway GO:0007186 10.25 S1PR3 PTAFR PF4 CXCL8 CXCL5 CCR6
3 positive regulation of gene expression GO:0010628 10.1 TNF TLR4 PF4 IL18 CRP
4 immune response GO:0006955 10.07 TNF TLR4 PTAFR PF4 IL1RN IL18
5 regulation of cell proliferation GO:0042127 9.99 TNF PF4 NOS2 MIF
6 leukocyte migration GO:0050900 9.99 TNF SELE MIF ELANE
7 chemotaxis GO:0006935 9.97 PTAFR PF4 CXCL8 CXCL5 CCR6
8 defense response to bacterium GO:0042742 9.97 TNF TLR4 NOS2 LBP IL10 ELANE
9 defense response GO:0006952 9.96 TNF PF4 CXCL8 CXCL5
10 cytokine-mediated signaling pathway GO:0019221 9.96 VCAM1 TNF PTAFR PF4 NOS2 LBP
11 neutrophil chemotaxis GO:0030593 9.93 PF4 IL1RN CXCL8 CXCL5
12 regulation of inflammatory response GO:0050727 9.9 TNF TLR4 SELE
13 chemokine-mediated signaling pathway GO:0070098 9.9 PF4 CXCL8 CXCL5 CCR6
14 phagocytosis GO:0006909 9.89 TLR4 ELANE CD14
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 TNF TLR4 IL18 CD14
16 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.88 PF4 CXCL8 CXCL5
17 positive regulation of interleukin-6 production GO:0032755 9.88 TNF TLR4 LBP IL1RN
18 positive regulation of tumor necrosis factor production GO:0032760 9.88 TLR4 PTAFR PF4 MIF LBP CD14
19 response to glucocorticoid GO:0051384 9.87 TNF IL1RN IL10
20 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.87 TNF TLR4 CD14
21 apoptotic signaling pathway GO:0097190 9.87 TNF TLR4 CD14
22 positive regulation of MAP kinase activity GO:0043406 9.86 TNF MIF ELANE
23 positive regulation of smooth muscle cell proliferation GO:0048661 9.86 TNF PTAFR IL18 ELANE
24 negative regulation of tumor necrosis factor production GO:0032720 9.85 TLR4 LBP IL10
25 toll-like receptor signaling pathway GO:0002224 9.83 TLR4 LBP CD14
26 negative regulation of interleukin-6 production GO:0032715 9.82 TNF TLR4 IL10
27 leukocyte cell-cell adhesion GO:0007159 9.81 VCAM1 SELE CALCA
28 positive regulation of interferon-gamma production GO:0032729 9.81 TNF TLR4 IL18 CD14
29 response to lipopolysaccharide GO:0032496 9.81 VCAM1 TLR4 SELE PTAFR NOS2 LBP
30 positive regulation of chemokine production GO:0032722 9.8 TNF TLR4 LBP
31 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 TNF TLR4 PTAFR LBP IL18 CD14
32 leukocyte tethering or rolling GO:0050901 9.79 VCAM1 TNF SELE
33 toll-like receptor 4 signaling pathway GO:0034142 9.79 TLR4 LBP CD14
34 positive regulation of macrophage activation GO:0043032 9.78 TLR4 LBP IL10
35 positive regulation of cytokine secretion GO:0050715 9.78 TNF MIF IL10 CD14
36 positive regulation of interleukin-8 production GO:0032757 9.76 TNF TLR4 LBP CALCA
37 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.74 TNF TLR4 ELANE
38 leukocyte chemotaxis GO:0030595 9.73 PF4 IL10 CXCL8 CXCL5
39 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.72 IL1RN IL10
40 positive regulation of MHC class II biosynthetic process GO:0045348 9.72 TLR4 IL10
41 response to molecule of bacterial origin GO:0002237 9.72 IL10 CXCL8 CD14
42 T-helper 1 type immune response GO:0042088 9.71 TLR4 IL18
43 negative regulation of lipid storage GO:0010888 9.71 TNF CRP
44 opsonization GO:0008228 9.71 LBP CRP
45 cellular response to lipoteichoic acid GO:0071223 9.71 TLR4 LBP CD14
46 leukocyte migration involved in inflammatory response GO:0002523 9.7 SELE ELANE CCR6
47 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
48 negative regulation of MyD88-independent toll-like receptor signaling pathway GO:0034128 9.68 TLR4 CD14
49 negative regulation of cytokine secretion involved in immune response GO:0002740 9.67 TNF IL10
50 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.67 TNF MIF

Molecular functions related to Bacterial Sepsis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 TNF TLR4 SELE S1PR3 PTAFR PF4
2 chemokine activity GO:0008009 9.54 PF4 CXCL8 CXCL5
3 lipopeptide binding GO:0071723 9.4 LBP CD14
4 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 PTAFR
5 lipoteichoic acid binding GO:0070891 9.26 LBP CD14
6 lipopolysaccharide binding GO:0001530 9.26 TLR4 PTAFR LBP CD14
7 cytokine activity GO:0005125 9.17 TNF PF4 MIF IL1RN IL18 IL10
Sources

Sources for Bacterial Sepsis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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