Bacterial Sepsis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BCT021 MIFTS: 43	Bacterial Sepsis Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Bacterial Sepsis

MalaCards integrated aliases for Bacterial Sepsis:

Name: Bacterial Sepsis ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0040085

ICD9CM ³⁴ 995.91

SNOMED-CT ⁶⁷ 10001005

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Summaries for Bacterial Sepsis

Disease Ontology : ¹² A bacterial infectious disease has material basis in Bacteria.

MalaCards based summary : Bacterial Sepsis is related to sepsis in premature infants and severe acute respiratory syndrome. An important gene associated with Bacterial Sepsis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, neutrophil and endothelial, and related phenotypes are hematopoietic system and cardiovascular system

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Related Diseases for Bacterial Sepsis

Diseases related to Bacterial Sepsis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 535)

#	Related Disease	Score	Top Affiliating Genes
1	sepsis in premature infants	31.7	CRP CALCA
2	severe acute respiratory syndrome	30.6	TNF TLR4 IL10 CXCL8 CRP
3	disseminated intravascular coagulation	30.6	TNF IL10 ELANE CRP
4	haemophilus influenzae	30.5	TNF CXCL8
5	perinatal necrotizing enterocolitis	30.4	TNF TLR9 TLR4 IL10 CXCL8 CRP
6	candidiasis	30.4	TNF TLR4 IL10 CXCL8
7	smallpox	30.3	TNF IL1RN IL18
8	enterocolitis	30.3	TNF TLR4 IL10 CXCL8 CRP CD14
9	urinary tract infection	30.3	TLR4 CRP
10	exanthem	30.3	TNF IL18 IL10 CXCL8 CRP
11	meningoencephalitis	30.3	TNF IL10 CRP
12	neutropenia	30.2	TNF TLR4 IL1RN IL10 ELANE CXCL8
13	shwartzman phenomenon	30.2	VCAM1 TNF SELE
14	purpura	30.2	TNF IL10 CRP
15	bacteriuria	30.2	TLR4 IL18 CXCL8 CRP
16	toxoplasmosis	30.2	TNF TLR9 TLR4 IL10
17	bacterial meningitis	30.2	TNF TLR9 TLR4 IL18 IL10 CXCL8
18	allergic disease	30.1	TNF TLR9 TLR4 IL18
19	bronchopulmonary dysplasia	30.1	IL1RN ELANE CXCL8
20	toxic shock syndrome	30.1	TNF TLR4 NOS2 MIF LBP IL1RN
21	klebsiella pneumonia	30.1	TNF TLR4 IL10 CXCL8 CRP
22	otitis media	30.1	TNF TLR4 IL10 CXCL8 CRP
23	cholangitis	30.1	TNF TLR4 IL10 CXCL8 CRP
24	septic arthritis	30.1	TLR9 TLR4 CXCL8 CRP CALCA
25	extrapulmonary tuberculosis	30.1	LBP IL1RN IL10 CRP
26	diarrhea	30.1	TNF TLR4 IL10 CXCL8 CALCA
27	acquired immunodeficiency syndrome	30.0	VCAM1 TNF SELE NOS2 IL10 CRP
28	meningitis	30.0	TNF TLR9 TLR4 LBP IL18 IL10
29	disease by infectious agent	30.0	TNF TLR9 TLR4 LBP IL1RN IL18
30	osteomyelitis	30.0	TNF TLR4 IL1RN IL10 CXCL8 CRP
31	acute cystitis	29.9	TNF TLR4 IL18 IL10 CXCL8 CRP
32	lymphadenitis	29.9	TNF TLR4 IL18 IL10 CXCL8 CRP
33	leishmaniasis	29.9	TNF TLR9 TLR4 NOS2 IL18 IL10
34	peritonitis	29.9	TNF TLR4 LBP IL18 IL10 ELANE
35	plasmodium falciparum malaria	29.9	TNF SELE NOS2 MIF IL18 IL10
36	glomerulonephritis	29.9	VCAM1 NOS2 MIF ELANE
37	myocarditis	29.8	VCAM1 TNF TLR4 NOS2 IL18 IL10
38	liver cirrhosis	29.8	TNF TLR4 LBP IL10 CRP CD14
39	gastroenteritis	29.7	TNF TLR9 IL1RN IL10 CXCL8 CRP
40	bacterial infectious disease	29.7	TNF TLR9 TLR4 MIF LBP IL1RN
41	endocarditis	29.7	VCAM1 TNF PF4 LBP IL10 CXCL8
42	thrombocytopenia	29.6	TNF TLR9 TLR4 SELE PF4 IL1RN
43	cystic fibrosis	29.6	TNF TLR4 NOS2 LBP IL10 ELANE
44	body mass index quantitative trait locus 11	29.5	VCAM1 TNF TLR4 SELE IL18 IL10
45	respiratory failure	29.4	TNF TLR4 PF4 IL1RN IL10 ELANE
46	pre-eclampsia	29.4	VCAM1 TNF TLR4 SELE NOS2 IL18
47	visceral leishmaniasis	29.4	TNF TLR9 TLR4 NOS2 MIF IL18
48	arthritis	29.0	VCAM1 TNF TLR4 MIF IL1RN IL18
49	adult respiratory distress syndrome	28.8	TNF SELE NOS2 MIF LBP IL1RN
50	malaria	28.6	VCAM1 TNF TLR9 TLR4 SELE PF4

Graphical network of the top 20 diseases related to Bacterial Sepsis:

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Symptoms & Phenotypes for Bacterial Sepsis

MGI Mouse Phenotypes related to Bacterial Sepsis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.13	CD14 ELANE IL10 IL18 IL1RN LBP
2	cardiovascular system	MP:0005385	10.06	CRP IL10 IL18 IL1RN NOS2 PTAFR
3	homeostasis/metabolism	MP:0005376	10.06	CD14 CRP ELANE IL10 IL18 IL1RN
4	immune system	MP:0005387	9.86	CD14 CRP ELANE IL10 IL18 IL1RN
5	integument	MP:0010771	9.28	ELANE IL10 IL18 IL1RN NOS2 S1PR3

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Drugs & Therapeutics for Bacterial Sepsis

Drugs for Bacterial Sepsis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Antibiotics, Antitubercular

Phase 4

Anti-Bacterial Agents

Phase 4

Immunoglobulins

Phase 4

Antibodies

Phase 4

Immunoglobulin A

Phase 4

Immunoglobulins, Intravenous

Phase 4

Anti-Infective Agents

Phase 3

Antitubercular Agents

Phase 3

Vancomycin

Approved

Phase 2

1404-90-6

441141 14969

Synonyms:

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-a-L-lyxo-hexopyranosyl)-b-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate

(1S,2R,18R,22S,25R,28R,40S)-22-(2-Amino-2-oxoethyl)-48-[2-O-(3-amino-2,3,6-trideoxy-3-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyloxy]-5,15-dichloro-2,18,32,35,37-pentahydroxy-19-[(N-methyl-D-leucyl)amino]-20,23,26,42,44-pentaoxo-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.2(3,6).2(14,17).1(8,12).1(29,33).0(10,25).0(34,39)]pentaconta-3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49-pentadecaene-40-carboxylate

(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-beta-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-beta-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]

(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-b-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-a-L-lyxo-hexopyranosyl)-b-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-b-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]

(2.2Sp,3.5Sa,2.6Sp)-O(4.2),C(3.4):C(5.4),O(4.6):c(3.5),C(2.7)-tricyclo[N-methyl-D-leucyl-3-chloro-(R)-β-hydroxy-D-tyrosyl-L-asparaginyl-D-2-(4-{[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy}phenyl)glycyl-D-2-(4-hydroxyphenyl)glycyl-3-chloro-(R)-β-hydroxy-L-tyrosyl-L-2-(3,5-dihydroxyphenyl)glycine]

1404-90-6

1404-93-9 (hydrochloride)

64685-75-2 (sulfate)

Abbott brand OF vancomycin hydrochloride

AB-vancomycin

AC1L24VU

AC1L9AMI

AC1Q29OH

Azupharma brand OF vancomycin hydrochloride

BIDD:GT0353

C06689

C66H75Cl2N9O24

Cell pharm brand OF vancomycin hydrochloride

CHEBI:28001

CHEMBL262777

Chiesi brand OF vancomycin hydrochloride

CID14969

CID441141

CID5311496

CID6426898

CID6917992

Combino brand OF vancomycin hydrochloride

Curasan brand OF vancomycin hydrochloride

D00212

Dakota brand OF vancomycin hydrochloride

DB00512

Diatracin

Dista brand OF vancomycin hydrochloride

EINECS 215-772-6

Eli lilly brand OF vancomycin hydrochloride

Hexal brand OF vancomycin hydrochloride

HSDB 3262

Hydrochloride, vancomycin

Lilly brand OF vancomycin hydrochloride

LMPK14000004

Lopac0_001267

LS-161387

MIP brand OF vancomycin hydrochloride

MolPort-001-794-649

NCGC00162383-02

nchembio.350-comp1

Norman brand OF vancomycin hydrochloride

Prestwick0_000497

Prestwick1_000497

Prestwick2_000497

Ratiopharm brand OF vancomycin hydrochloride

SPBio_002314

Sulfate, vancomycin

UNII-6Q205EH1VU

VAN

Vanco azupharma

Vanco-cell

Vancocin

Vancocin (TN)

Vancocin HCL

Vancocine

Vancoled

Vancomicin

Vancomicina

Vancomicina [INN-Spanish]

Vancomicina abbott

Vancomicina chiesi

Vancomicina combino phar

Vancomicina norman

Vancomycin

VANCOMYCIN

Vancomycin (USP)

Vancomycin [USAN:INN:BAN]

Vancomycin HCL

Vancomycin hexal

Vancomycin hydrochloride

Vancomycin lilly

Vancomycin phosphate (1:2)

Vancomycin phosphate (1:2), decahydrate

Vancomycin sulfate

Vancomycine

Vancomycine [INN-French]

Vancomycine dakota

Vancomycin-ratiopharm

Vancomycinum

Vancomycinum [INN-Latin]

Vancor

Vanco-saar

methicillin

Phase 2

Vaccines

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Procalcitonin-Guided Antimicrobial Discontinuation Strategy in Critically Ill Patients With Suspected or Confirmed Bacterial Sepsis	Completed	NCT00250666	Phase 4
2	A Prospective Study to Analyze the Efficacy of IgM Rich Immunoglobulin as an Adjunct to Antibiotics in the Treatment of Bacterial Sepsis in Very Low Birth Weight Preterm Neonates	Completed	NCT03403530	Phase 4	IgM rich Immunoglobin
3	Comparison of the Efficacy of a 7-day Versus 14-day Course of Intravenous Antibiotics in the Treatment of Uncomplicated Neonatal Bacterial Sepsis: a Randomized Controlled Non-inferiority Trial	Recruiting	NCT03280147	Phase 3	7-day course of antibiotics;14-day course of antibiotics
4	Multi-centre, Randomised, Open Label, Phase IIb Study to Compare the Efficacy, Safety and Pharmacokinetics (PK) of an Optimised Dosing to a Standard Dosing Regimen of Vancomycin in Neonates and Infants Aged ≤ 90 Days With Late Onset Bacterial Sepsis Known or Suspected to be Caused by Gram-positive Microorganisms	Terminated	NCT02790996	Phase 2	Vancomycin
5	A Randomized, Partial-Blinded, Placebo-Controlled, Phase I Safety and Immunogenicity Study in Healthy Subjects of Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram Negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant	Terminated	NCT01164514	Phase 1	Placebo
6	Diagnostic Performance of a New Bio-marker During Bacterial Sepsis	Unknown status	NCT02721134
7	Characterization of the Inflammatory Profile of Patients With Macrophage Activation Syndrome Secondary to Bacterial Sepsis	Unknown status	NCT03721809
8	Early Detection and Diagnostic Performance of Bio-markers During Bacterial Sepsis: Multicentre Cohort Study in Intensive Care	Completed	NCT01378169
9	Pilot Study of Low-Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock	Recruiting	NCT03343041

Search NIH Clinical Center for Bacterial Sepsis

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Genetic Tests for Bacterial Sepsis

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Anatomical Context for Bacterial Sepsis

MalaCards organs/tissues related to Bacterial Sepsis:

⁴⁰

Liver, Neutrophil, Endothelial, Kidney, Bone, Bone Marrow, Myeloid

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Publications for Bacterial Sepsis

Articles related to Bacterial Sepsis:

(show top 50) (show all 1627)

#	Title	Authors	PMID	Year
1	Do isolates from pharyngeal and rectal swabs match blood culture bacterial pathogens in septic VLBW infants? A pilot, cross-sectional study. ⁶¹	Capasso L...Raimondi F	32860099	2021
2	A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood. ⁶¹	Ng DL...Chiu CY	33536218	2021
3	Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission. ⁶¹	Ortillon M...Monneret G	33547747	2021
4	Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019. ⁶¹	Sweeney TE...Giamarellos-Bourboulis EJ	33201004	2021
5	IOX1 activity as sepsis therapy and an antibiotic against multidrug-resistant bacteria. ⁶¹	Lee SJ...Park YM	33536477	2021
6	A pregnancy-specific reference interval for procalcitonin. ⁶¹	Dockree S...Vatish M	33307062	2021
7	Mycotic Aneurysm of Brachial Artery in Case of Aplastic Anemia. ⁶¹	Patra PC...Kashyap R	33527820	2021
8	Bacterial sepsis increases hippocampal fibrillar amyloid plaque load and neuroinflammation in a mouse model of Alzheimer's disease. ⁶¹	Basak JM...Musiek ES	33556539	2021
9	Platelet FcγRIIA in Immunity and Thrombosis: Adaptive Immunothrombosis. ⁶¹	Patel P...McKenzie SE	33587783	2021
10	Key challenges in providing effective antibiotic therapy for critically ill patients with bacterial sepsis and septic shock. ⁶¹	Landersdorfer CB...Nation RL	33570163	2021
11	Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis. ⁶¹	Lee SJ...Park YM	33588136	2021
12	Relationship between influenza and dengue outbreaks, and subsequent bacterial sepsis in French Guiana: A time series analysis. ⁶¹	Cropet C...Nacher M	33553058	2021
13	Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis. ⁶¹	Singh S...Soares MP	33497603	2021
14	Time for pragmatic, prospective clinical trials to determine the role of empirical antibacterial therapy in critically ill adults hospitalized with malaria. ⁶¹	Hanson J...Kyi MM	33017698	2021
15	Therapeutic plasma exchange followed by convalescent plasma transfusion in critical COVID-19-An exploratory study. ⁶¹	Jaiswal V...Marashi M	33157287	2021
16	Vancomycin in neonatal sepsis: predictive performance of a Chinese neonatal population pharmacokinetic model and clinical efficacy evaluation. ⁶¹	Weng XH...Tang L	33472817	2021
17	Hemophagocytic Lymphohistiocytosis in a PICU of a Developing Economy: Clinical Profile, Intensive Care Needs, Outcome, and Predictors of Mortality. ⁶¹	Parajuli B...Jayashree M	33031348	2021
18	Inertial-based Fluidic Platform for Rapid Isolation of Blood-borne Pathogens. ⁶¹	Batcho EC...Giorgio TD	33499487	2021
19	The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review. ⁶¹	Al Duhailib Z...Nair P	33495945	2021
20	Omega-3 fatty acid lipid emulsions are safe and effective in reducing endotoxemia and sepsis in acute-on-chronic liver failure: An open-label randomized controlled trial. ⁶¹	Kulkarni AV...Sarin SK	33450081	2021
21	HTLV-I and Strongyloides in Australia: The worm lurking beneath. ⁶¹	Gordon CA...McManus DP	33482974	2021
22	Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis. ⁶¹	Yang Y...Tang Y	33333514	2021
23	Diagnosis of Neonatal Late-Onset Infection in Very Preterm Infant: Inter-Observer Agreement and International Classifications. ⁶¹	Bury G...Beuchee A	33498557	2021
24	Mesenchymal stromal cells expressing a dominant-negative high mobility group A1 transgene exhibit improved function during sepsis. ⁶¹	Kwon MY...Perrella MA	33438259	2021
25	COVID-19: should we consider it as a septic shock? (The treatment of COVID-19 patients in the ICU). ⁶¹	Roger C	33470663	2021
26	Peritoneal dialysis in critically ill children in resource-limited setting: A prospective cohort study. ⁶¹	Choudhary P...Thakur A	33272115	2020
27	Sepsis and Cancer: An Interplay of Friends and Foes. ⁶¹	Mirouse A...Pene F	32813980	2020
28	Effects of hypercapnia in sepsis: A scoping review of clinical and pre-clinical data. ⁶¹	Clyde TP...Roberts BW	33315238	2020
29	Novel TLR2xTLR4 Bispecific Antibody Inhibits Bacterial Sepsis. ⁶¹	Sato M...Suzuki J	33347385	2020
30	Ampicillin triggers the release of Pal in toxic vesicles from Escherichia coli. ⁶¹	Michel LV...Pichichero ME	32941946	2020
31	Endotoxemia and circulating bacteriome in severe COVID-19 patients. ⁶¹	Sirivongrangson P...Srisawat N	33284413	2020
32	Interleukin-10 (IL-10) 1082 promoter Polymorphisms and plasma IL-10 levels in patients with bacterial sepsis. ⁶¹	Vivas MC...Sanchez CA	33155998	2020
33	Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. ⁶¹	De Oliveira DMP...Walker MJ	33208501	2020
34	Outcomes with nondose-dense chemotherapy for Ewing sarcoma: A practical approach for the developing world. ⁶¹	Parambil BC...Banavali S	32706522	2020
35	Individualized versus standard diet fortification for growth and development in preterm infants receiving human milk. ⁶¹	Fabrizio V...Hagadorn JI	33226632	2020
36	Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study. ⁶¹	Kuhn D...Becker SL	33239110	2020
37	Compassionate use of remdesivir in children with COVID-19. ⁶¹	Mendez-Echevarria A...Calvo C	33200304	2020
38	miRNA-23b as a biomarker of culture-positive neonatal sepsis. ⁶¹	Fatmi A...Pallardo FV	33032520	2020
39	The effect of foal or adult horse plasma on equine monocyte-derived dendritic cell phenotype and function. ⁶¹	Lopez BS...Hart KA	32717449	2020
40	Temporal changes of NF-κB signaling pathway genes in bacterial stimulated whole blood- a host mechanism associated with sepsis. ⁶¹	Anirudhan A...Ahmed SSSJ	32738283	2020
41	Impact of Aeromonas hydrophila and infectious spleen and kidney necrosis virus infections on susceptibility and host immune response in Chinese perch (Siniperca chuatsi). ⁶¹	Liu X...Zhang X	32653585	2020
42	Respiratory viral sepsis: epidemiology, pathophysiology, diagnosis and treatment. ⁶¹	Gu X...Cao B	32699026	2020
43	One disease, many faces-typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease. ⁶¹	Philips CA...Augustine P	33024752	2020
44	Evaluation of Inflammatory Biomarkers in Pediatric Hematology-Oncology Patients With Bloodstream Infection. ⁶¹	Chen S...Wen F	32941295	2020
45	Magnitude, trend, and causes of under-five mortality from Kilite-Awlaelo health demographic surveillance database, northern Ethiopia, 2009-2017. ⁶¹	Abraha HE...Assefa NE	32993625	2020
46	IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome. ⁶¹	Kang S...Kishimoto T	32826331	2020
47	RIPK3 collaborates with GSDMD to drive tissue injury in lethal polymicrobial sepsis. ⁶¹	Chen H...Xu Y	32152555	2020
48	Coagulopathy in COVID-19. ⁶¹	Iba T...Thachil J	32558075	2020
49	Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19. ⁶¹	Reyes M...Hacohen N	32908980	2020
50	Sepsis from an apheresis platelet contaminated with Acinetobacter calcoaceticus/baumannii complex bacteria and Staphylococcus saprophyticus after pathogen reduction. ⁶¹	Fridey JL...Busch MP	32738079	2020

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Genes for Bacterial Sepsis

Genes related to Bacterial Sepsis (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TLR4	Toll Like Receptor 4	Protein Coding	14.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TNF	Tumor Necrosis Factor	Protein Coding	14.43	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	CRP	C-Reactive Protein	Protein Coding	13.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	IL10	Interleukin 10	Protein Coding	13.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	13.38	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	12.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	LBP	Lipopolysaccharide Binding Protein	Protein Coding	12.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	TLR9	Toll Like Receptor 9	Protein Coding	12.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	IL18	Interleukin 18	Protein Coding	12.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	SELE	Selectin E	Protein Coding	12.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	NOS2	Nitric Oxide Synthase 2	Protein Coding	12.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	12.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	ELANE	Elastase, Neutrophil Expressed	Protein Coding	12.12	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	11.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	PTAFR	Platelet Activating Factor Receptor	Protein Coding	11.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	PF4	Platelet Factor 4	Protein Coding	11.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	MIF	Macrophage Migration Inhibitory Factor	Protein Coding	11.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	11.36	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	CD14	CD14 Molecule	Protein Coding	11.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	CXCL5	C-X-C Motif Chemokine Ligand 5	Protein Coding	10.92	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	MIR150	MicroRNA 150	RNA Gene	10.26	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.5	DISEASES inferred ¹⁵ ¹⁵
23	IL6	Interleukin 6	Protein Coding	7.26	DISEASES inferred ¹⁵
24	TLR2	Toll Like Receptor 2	Protein Coding	7.04	DISEASES inferred ¹⁵
25	IL1B	Interleukin 1 Beta	Protein Coding	6.86	DISEASES inferred ¹⁵
26	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	6.83	GeneCards inferred via : Publications (show sections)
27	FAH	Fumarylacetoacetate Hydrolase	Protein Coding	6.83	GeneCards inferred via : Publications (show sections)

Sources

Variations for Bacterial Sepsis

Sources

Expression for Bacterial Sepsis

Search GEO for disease gene expression data for Bacterial Sepsis.

Sources

Pathways for Bacterial Sepsis

Pathways related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show all 48)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.02	VCAM1 TNF TLR9 TLR4 PTAFR NOS2
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.71	TNF TLR4 PF4 NOS2 MIF IL1RN
3	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.43	TNF TLR9 TLR4 PF4 IL18 IL10
4	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.4	VCAM1 TNF PTAFR NOS2 LBP IL1RN
5	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.09	TNF TLR9 TLR4 NOS2 LBP IL10
6	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.81	TNF TLR9 TLR4 IL18 CXCL8
7	Salmonella infection (KEGG) ³⁶ Show member pathways Salmonella infection ³⁶	12.78	TNF TLR9 TLR4 IL18 CXCL8 CD14
8	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²³ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²³ NOD-like Receptor Signaling Pathways ⁶⁴	12.75	TNF TLR9 TLR4 NOS2 IL1RN IL18
9	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.61	TNF NOS2 IL18 IL10 CD14
10	NF-kappaB Signaling ⁴	12.59	VCAM1 TNF TLR9 IL1RN IL10
11	Shigellosis ³⁶	12.45	TNF TLR4 IL18 CXCL8 CD14
12	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.39	TNF PF4 IL18 IL10 CXCL8 CXCL5
13	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.36	TNF TLR4 NOS2 MIF LBP CXCL8
14	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.31	TNF TLR9 TLR4 CXCL8 CD14
15	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.27	TNF TLR4 NOS2 IL10
16	NOD-like receptor signaling pathway ³⁶	12.25	TNF TLR4 IL18 CXCL8
17	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	12.22	TNF TLR9 TLR4 NOS2 LBP CXCL8
18	Colorectal Cancer Metastasis ⁶³	12.21	TNF TLR9 TLR4 NOS2
19	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.2	TNF IL1RN IL10 CXCL8
20	Yersinia infection ³⁶	12.15	TNF TLR4 IL18 IL10 CXCL8
21	Tuberculosis ³⁶	12.11	TNF TLR9 TLR4 NOS2 LBP IL18
22	Spinal Cord Injury ¹	12.07	TNF TLR4 NOS2 MIF CXCL8
23	TNF signaling pathway ³⁶	12.02	VCAM1 TNF SELE CXCL5
24	NF-kappa B signaling pathway ³⁶	11.99	VCAM1 TNF TLR4 LBP CXCL8 CD14
25	Interleukin-4 and 13 signaling ⁶⁵	11.97	VCAM1 TNF NOS2 LBP IL18 IL10
26	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.96	VCAM1 TNF SELE CXCL8
27	Amoebiasis ³⁶	11.96	TNF TLR4 NOS2 IL10 CXCL8 CD14
28	Rheumatoid arthritis ³⁶	11.93	TNF TLR4 IL18 CXCL8 CXCL5
29	Cytokine production by Th17 cells in CF (Mouse model) ²³ Show member pathways Cytokine production by Th17 cells in CF ²³	11.92	TLR4 LBP CXCL8 CD14
30	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.84	TNF TLR9 TLR4 IL18 IL10
31	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.81	TNF TLR9 IL10 CD14
32	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.78	TNF IL18 IL10
33	IgA-Producing B Cells in the Intestine ⁶⁴	11.73	VCAM1 TNF TLR9 TLR4 NOS2 IL10
34	Legionellosis ³⁶	11.69	TNF TLR4 IL18 CXCL8 CD14
35	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.68	VCAM1 TNF SELE NOS2 MIF CXCL8
36	Lung fibrosis ¹	11.67	TNF CXCL8 CALCA
37	Transcription_NF-kB signaling pathway ²³	11.65	TNF TLR4 LBP CD14
38	ATF-2 transcription factor network ¹	11.61	SELE NOS2 CXCL8
39	MSP-RON Signaling ⁶³	11.59	TNF TLR4 NOS2 IL18
40	Interleukin-10 signaling ⁶⁵	11.49	TNF PTAFR IL1RN IL18 IL10 CXCL8
41	IL-10 Pathway ⁶³	11.43	TNF TLR4 IL10 CD14
42	Pertussis ³⁶	11.38	TNF TLR4 NOS2 IL10 CXCL8 CXCL5
43	African trypanosomiasis ³⁶	11.2	VCAM1 TNF TLR9 SELE IL18 IL10
44	Cellular roles of Anthrax toxin ¹	11.17	VCAM1 TNF IL18
45	Overview of nanoparticle effects ¹	11.1	TNF CXCL8 CRP
46	G-protein signaling_Rap2B regulation pathway ²³	11.05	TNF PF4 IL18 IL10 CXCL8 CXCL5
47	Malaria ³⁶	10.92	VCAM1 TNF TLR9 TLR4 SELE IL18
48	MIF Action Through Endocytic Pathway ⁶³	10.88	TLR4 MIF CD14

Sources

GO Terms for Bacterial Sepsis

Cellular components related to Bacterial Sepsis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.83	TNF TLR9 S1PR3 PF4 MIF LBP
2	cell surface	GO:0009986	9.7	VCAM1 TNF TLR4 MIF LBP ELANE
3	extracellular space	GO:0005615	9.5	VCAM1 TNF SELE PF4 MIF LBP
4	lipopolysaccharide receptor complex	GO:0046696	9.26	TLR4 CD14

Biological processes related to Bacterial Sepsis according to GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.33	TLR9 TLR4 S1PR3 PTAFR IL1RN IL18
2	innate immune response	GO:0045087	10.14	TLR9 TLR4 MIF LBP CRP CD14
3	immune response	GO:0006955	10.13	TNF TLR9 TLR4 PTAFR PF4 IL1RN
4	positive regulation of gene expression	GO:0010628	10.12	TNF TLR9 TLR4 PF4 IL18 CXCL8
5	defense response to bacterium	GO:0042742	10.02	TNF TLR9 TLR4 NOS2 LBP IL10
6	leukocyte migration	GO:0050900	9.99	TNF SELE MIF ELANE
7	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.97	TNF TLR9 TLR4 IL18
8	chemotaxis	GO:0006935	9.97	PTAFR PF4 CXCL8 CXCL5
9	defense response	GO:0006952	9.97	TNF PF4 CXCL8 CXCL5
10	cytokine-mediated signaling pathway	GO:0019221	9.96	VCAM1 TNF PTAFR PF4 NOS2 LBP
11	positive regulation of tumor necrosis factor production	GO:0032760	9.95	TLR9 TLR4 PTAFR PF4 MIF LBP
12	positive regulation of inflammatory response	GO:0050729	9.93	TNF TLR9 TLR4 IL18
13	defense response to Gram-negative bacterium	GO:0050829	9.93	TLR9 TLR4 NOS2 LBP
14	positive regulation of interleukin-6 production	GO:0032755	9.92	TNF TLR9 TLR4 PTAFR LBP
15	negative regulation of interleukin-6 production	GO:0032715	9.91	TNF TLR9 TLR4 IL10
16	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.91	TNF TLR9 TLR4 IL18 CD14
17	positive regulation of JNK cascade	GO:0046330	9.9	TNF TLR9 TLR4
18	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.9	TNF TLR9 TLR4 CD14
19	neutrophil chemotaxis	GO:0030593	9.89	PF4 CXCL8 CXCL5
20	phagocytosis	GO:0006909	9.89	TLR4 ELANE CD14
21	negative regulation of tumor necrosis factor production	GO:0032720	9.89	TLR4 LBP IL10
22	positive regulation of smooth muscle cell proliferation	GO:0048661	9.89	TNF PTAFR IL18 ELANE
23	positive regulation of interferon-gamma production	GO:0032729	9.89	TNF TLR9 TLR4 IL18 CD14
24	apoptotic signaling pathway	GO:0097190	9.88	TNF TLR4 CD14
25	chemokine-mediated signaling pathway	GO:0070098	9.88	PF4 CXCL8 CXCL5
26	antimicrobial humoral immune response mediated by antimicrobial peptide	GO:0061844	9.88	PF4 CXCL8 CXCL5
27	positive regulation of cytokine production	GO:0001819	9.88	TNF MIF IL10 CD14
28	response to glucocorticoid	GO:0051384	9.87	TNF IL1RN IL10
29	positive regulation of interleukin-8 production	GO:0032757	9.87	TNF TLR9 TLR4 LBP ELANE CD14
30	toll-like receptor signaling pathway	GO:0002224	9.86	TLR9 TLR4 LBP CD14
31	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.85	TNF TLR4 PTAFR LBP IL18 CD14
32	positive regulation of chemokine production	GO:0032722	9.84	TNF TLR9 TLR4 LBP
33	negative regulation of interleukin-8 production	GO:0032717	9.83	TLR9 IL10 ELANE
34	positive regulation of B cell proliferation	GO:0030890	9.83	TLR9 TLR4 MIF
35	acute-phase response	GO:0006953	9.83	LBP IL1RN CRP
36	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.82	TLR9 TLR4 CD14
37	leukocyte cell-cell adhesion	GO:0007159	9.82	VCAM1 SELE CALCA
38	negative regulation of blood pressure	GO:0045776	9.81	PTAFR NOS2 CALCA
39	response to lipopolysaccharide	GO:0032496	9.81	VCAM1 TLR4 SELE PTAFR NOS2 LBP
40	leukocyte tethering or rolling	GO:0050901	9.8	VCAM1 TNF SELE
41	positive regulation of macrophage activation	GO:0043032	9.79	TLR4 LBP IL10
42	toll-like receptor 4 signaling pathway	GO:0034142	9.79	TLR4 LBP CD14
43	response to molecule of bacterial origin	GO:0002237	9.76	TLR9 IL10 CXCL8 CD14
44	cellular response to lipoteichoic acid	GO:0071223	9.74	TLR4 LBP CD14
45	positive regulation of neuroinflammatory response	GO:0150078	9.73	TNF IL18
46	I-kappaB phosphorylation	GO:0007252	9.73	TLR9 TLR4
47	positive regulation of MHC class II biosynthetic process	GO:0045348	9.72	TLR4 IL10
48	negative regulation of heterotypic cell-cell adhesion	GO:0034115	9.72	IL1RN IL10
49	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO:2000343	9.72	TNF TLR4
50	positive regulation of leukocyte tethering or rolling	GO:1903238	9.72	SELE PTAFR ELANE

Molecular functions related to Bacterial Sepsis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.41	TNF TLR9 TLR4 SELE S1PR3 PTAFR
2	chemokine activity	GO:0008009	9.54	PF4 CXCL8 CXCL5
3	lipopeptide binding	GO:0071723	9.4	LBP CD14
4	CXCR chemokine receptor binding	GO:0045236	9.33	PF4 CXCL8 CXCL5
5	lipopolysaccharide receptor activity	GO:0001875	9.32	TLR4 PTAFR
6	lipoteichoic acid binding	GO:0070891	9.26	LBP CD14
7	lipopolysaccharide binding	GO:0001530	9.26	TLR4 PTAFR LBP CD14
8	cytokine activity	GO:0005125	9.23	TNF PF4 MIF IL1RN IL18 IL10

Sources

Sources for Bacterial Sepsis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

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²⁷ GEO DataSets

²⁸ GO

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³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

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³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁵ MESH via Orphanet

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia