MCID: BCT002
MIFTS: 55

Bacterial Vaginosis

Categories: Reproductive diseases

Aliases & Classifications for Bacterial Vaginosis

MalaCards integrated aliases for Bacterial Vaginosis:

Name: Bacterial Vaginosis 12 76 55 3 15 63 73
Vaginosis, Bacterial 44

Classifications:



External Ids:

Disease Ontology 12 DOID:3385
MeSH 44 D016585
NCIt 50 C116973
SNOMED-CT 68 85569008
UMLS 73 C0085166

Summaries for Bacterial Vaginosis

PubMed Health : 63 About bacterial vaginosis: In bacterial vaginosis (sometime abbreviated as BV) much larger numbers of bacteria grow inside of the vagina than would normally just be there. This increase in bacteria is usually not dangerous and it often goes unnoticed, but it can cause a strong-smelling vaginal discharge and be very unpleasant. It also increases the risk of a vaginal infection. Antibiotics can provide effective treatment.

MalaCards based summary : Bacterial Vaginosis, also known as vaginosis, bacterial, is related to vaginitis and trichomoniasis. An important gene associated with Bacterial Vaginosis is PEPD (Peptidase D), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Metronidazole and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and bone, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 A vaginitis that is characterized by a grayish vaginal discharge usually of foul odor and the presence of Gardnerella vaginalis.

CDC : 3 Some women with BV don't know they have it because they have no symptoms. Having BV can increase your chance of getting an STD.

Wikipedia : 76 Bacterial vaginosis (BV) is a disease of the vagina caused by excessive growth of bacteria. Common... more...

Related Diseases for Bacterial Vaginosis

Diseases related to Bacterial Vaginosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 vaginitis 31.7 CXCL8 DEFB4A IL1B IL6 LAP3 PRF1
2 trichomoniasis 31.3 CXCL8 LAP3
3 cervicitis 30.7 CXCL8 DEFB4A
4 endometritis 30.6 IL1B IL6 TNF
5 vulvovaginal candidiasis 30.5 DEFB4A MBL2 TLR2
6 chlamydia 30.1 CXCL8 IL1A IL1B IL6 TLR2 TLR4
7 viral infectious disease 30.0 CXCL8 IL1B IL6 TNF
8 scabies 29.9 CXCL8 IL1A MBL2
9 placenta disease 29.9 CXCL8 IL1B IL6
10 cytomegalovirus infection 29.8 CXCL8 IL1B IL6 TNF
11 cystitis 29.7 CXCL8 IL6 TLR4 TNF
12 oral candidiasis 29.7 CXCL8 DEFB4A IL1A
13 chorioamnionitis 29.7 CXCL8 IL1A IL1B IL6 TLR4 TNF
14 cystic fibrosis 29.6 CXCL8 DEFB4A MBL2 TLR4
15 arthritis 29.5 CXCL8 IL1A IL1B IL6 TNF
16 periodontal disease 29.1 CXCL8 DEFB4A IL1A IL1B IL6 TLR2
17 vaginal discharge 11.6
18 candidiasis 10.7
19 human immunodeficiency virus infectious disease 10.5
20 pelvic inflammatory disease 10.4
21 herpes simplex 10.4
22 infertility 10.3
23 cervical intraepithelial neoplasia 10.3
24 ascaris lumbricoides infection 10.3 CXCL8 IL1B
25 peptic esophagitis 10.3 CXCL8 IL1B
26 campylobacteriosis 10.3 IL1B TLR4
27 actinic prurigo 10.3 IL1B TNF
28 retinitis pigmentosa 60 10.3 IL1B TNF
29 kashin-beck disease 10.3 IL1B TNF
30 burns 10.3 IL1B TNF
31 jejunoileitis 10.3 IL1B TNF
32 rheumatoid lung disease 10.3 IL1B TNF
33 staphylococcal toxic shock syndrome 10.3 IL1B TNF
34 superficial urinary bladder cancer 10.3 CXCL8 TLR4
35 pouchitis 10.3 CXCL8 TLR4
36 tungiasis 10.3 CXCL8 TNF
37 trichuriasis 10.3 CXCL8 TNF
38 cardiac sarcoidosis 10.3 CXCL8 TNF
39 clonorchiasis 10.3 CXCL8 TNF
40 chronic follicular conjunctivitis 10.2 IL1A IL1B
41 cardiac rupture 10.2 CXCL8 PRF1
42 leukoregulin 10.2 CXCL8 IL1A
43 macrophage activation syndrome 10.2 PRF1 TNF
44 systemic onset juvenile idiopathic arthritis 10.2 PRF1 TNF
45 skin conditions 10.2 IL1A TNF
46 chronic graft versus host disease 10.2 IL1A TNF
47 neurosyphilis 10.2 CXCL8 TLR2
48 mycobacterium kansasii 10.2 CXCL8 TLR2
49 mycobacterium marinum 10.2 CXCL8 TLR2
50 acute cervicitis 10.2 TLR2 TLR4

Graphical network of the top 20 diseases related to Bacterial Vaginosis:



Diseases related to Bacterial Vaginosis

Symptoms & Phenotypes for Bacterial Vaginosis

MGI Mouse Phenotypes related to Bacterial Vaginosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 IL1A IL1B IL6 PEPD PRF1 TLR2
2 hematopoietic system MP:0005397 9.97 IL1A IL1B IL6 MBL2 PEPD PRF1
3 homeostasis/metabolism MP:0005376 9.91 IL1A IL1B IL6 MBL2 PEPD PRF1
4 immune system MP:0005387 9.85 IL1A IL1B IL6 LAP3 MBL2 PEPD
5 integument MP:0010771 9.56 IL1A IL1B IL6 PEPD PRF1 TLR2
6 neoplasm MP:0002006 9.17 IL1A IL1B IL6 PRF1 TLR2 TLR4

Drugs & Therapeutics for Bacterial Vaginosis

PubMedHealth treatment related to Bacterial Vaginosis: 63

Symptomatic bacterial vaginosis is usually treated using antibiotics to kill the germs. Treatments are available in tablet form or as a suppository or cream for direct application.Another treatment option is suppositories or capsules containing living lactic acid bacteria. These treatments are designed to protect the vaginal flora and restore the correct balance. There is not yet enough evidence on the benefits of this method.Some women also try things like putting tampons that have been soaked in tea tree oil or natural yogurt in their vagina to create a more acidic environment for the vaginal flora, but there has not yet been any research about how effective or safe these kinds of home remedies are.

Drugs for Bacterial Vaginosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 176)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 443-48-1 4173
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 18323-44-9 29029
4
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 22916-47-8 4189
5
Clotrimazole Approved, Vet_approved Phase 4,Phase 3 23593-75-1 2812
6
Desogestrel Approved Phase 4,Phase 2,Phase 3 54024-22-5 40973
7
Ethinyl Estradiol Approved Phase 4,Phase 2,Phase 3 57-63-6 5991
8
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-28-2 5757
9
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3 28014-46-2
10 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 979-32-8
11
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 6917715 40976
12
Tinidazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 19387-91-8 5479
13
Progesterone Approved, Vet_approved Phase 4,Not Applicable 57-83-0 5994
14
Nystatin Approved, Vet_approved Phase 4,Phase 3 1400-61-9 11953884
15
Levonorgestrel Approved, Investigational Phase 4,Not Applicable 17489-40-6, 797-63-7 13109
16
Copper Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable,Early Phase 1 7440-50-8 27099
17
Azithromycin Approved Phase 4,Phase 2,Phase 3,Not Applicable 83905-01-5 55185 447043
18
Neomycin Approved, Vet_approved Phase 4,Phase 3 1404-04-2 8378
19
Polihexanide Approved, Investigational Phase 4 28757-47-3
20
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
21
Norelgestromin Approved, Investigational Phase 4 53016-31-2 13752005
22
Norethindrone Approved Phase 4 68-22-4 6230
23
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
24
Norethindrone enanthate Experimental Phase 4 3836-23-5
25 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
26 Antiviral Agents Phase 4,Not Applicable
27 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
28 Expectorants Phase 4
29 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
30 Respiratory System Agents Phase 4
31 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
32 Antioxidants Phase 4
33 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
34 Antidotes Phase 4
35 Free Radical Scavengers Phase 4
36 Protective Agents Phase 4,Phase 2
37 N-monoacetylcystine Phase 4
38 cysteine Phase 4
39 Clindamycin palmitate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
40 Acidophilus Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
41 Clindamycin phosphate Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
42 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
43 Antifungal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
44 Antitubercular Agents Phase 4,Not Applicable
45 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
46 Hormones Phase 4,Phase 3,Phase 2,Early Phase 1
47 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
48 Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1
49 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 181)
# Name Status NCT ID Phase Drugs
1 Role of N-Acetylcysteine in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4 N-Acetyl cysteine;Metronidazole + N-Acetyl cysteine;metronidazole
2 Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy Unknown status NCT01558388 Phase 4 Lactobacillus acidophilus;Placebo
3 Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections Unknown status NCT02860845 Phase 4 Antibiotic (Clindamycin);Antifungal (Clotrimazole)
4 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4 Etonogestrel /Ethinyl Estradiol Contraceptive Vaginal Ring
5 Treatment of Bacterial Vaginosis (BV) With Tinidazole Completed NCT00334633 Phase 4 tinidazole, metronidazole
6 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed NCT00464542 Phase 4 Metronidazole
7 Treatment of Bacterial Vaginosis Completed NCT00324818 Phase 4 metronidazole and azithromycin
8 Lactoserum (Dermacyd Femina®) and Prevention of Recurrence of Bacterial Vaginosis Completed NCT00556179 Phase 4 Lactoserum (Dermacyd Femina®)
9 Treatment of Bacterial Vaginosis Combined With Human Lactobacilli Completed NCT01245322 Phase 4 lactobacilli
10 Prevention of Very Preterm Delivery by Testing for and Treatment of Bacterial Vaginosis Completed NCT00642980 Phase 4 Clindamycin;Placebo;Clindamycin
11 Safety and Tolerability of Metronidazole Gel 1.3% Completed NCT02392026 Phase 4 Metronidazole Gel
12 Effects of Contraceptive Ring on Vaginal Microbiota, HIV Shedding and Local Immunity Completed NCT02445989 Phase 4 NuvaRing
13 Examining the Impact of Tampon Use on the Vaginal Microbiota Completed NCT03346759 Phase 4
14 N-Acetyl Cysteine for Prevention of Preterm Birth Completed NCT00568113 Phase 4 acetylcysteine in arm 1
15 Clindamycin to Reduce Preterm Birth in a Low Resource Setting Completed NCT01800825 Phase 4 Clindamycin;Placebo
16 Open Study of the Efficacy of the Local Treatment With Polygynax of Bacterial and/or Mycotic Vaginitis Completed NCT02444481 Phase 4 Polygynax combinaison of polymyxin, Neomycin and Nystatin
17 Antisepsis Regimen in the Surgical Treatment of Human Papilloma Virus Generated Cervical Lesions: Polyhexamethylene Biguanide Versus Chlorhexidine Completed NCT01740245 Phase 4
18 Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections Completed NCT01697826 Phase 4 ClinSupV3 -soft gelatin capsule;ClinSupV3ER- Extended release tablet
19 PARIS or PAtch RIng Study: A Trial to Evaluate NuvaRing Versus OrthoEvra Completed NCT00269620 Phase 4 ethinyl estradiol/etonogestrel vaginal ring;ethinyl estradiol/norelgestromin transdermal contraceptive
20 The Efficacy and Safety Study of Clindamycin Palmitate Hydrochloride Dispersible Tablet Treatment of Bacterial Vaginosis Recruiting NCT03080740 Phase 4 Clindamycin palmitate hydrochloride dispersible tablet;Metronidazole Tablet
21 Honghe Fujie Lotion for the Treatment of Bacterial Vaginosis Recruiting NCT03446443 Phase 4 Honghe Fujie lotion;Metronidazole Suppositories
22 Treatment Comparison of Antibiotics Versus Vaginal Lactic Acid in Non-pregnant Women With Acute Symptomatic Bacterial Vaginosis Recruiting NCT02042287 Phase 4 Metronidazole
23 Oral Metronidazole With Lactobacillus Vaginal Suppositories to Prevent Recurrence of Bacterial Vaginosis Recruiting NCT03099408 Phase 4 Metronidazole Oral;"Metronidazole" and "Lactobacillus"
24 The Effect of Norethisterone Enanthate on Recurrent Bacterial Vaginosis Recruiting NCT02905890 Phase 4 Norethisterone enantate
25 Effects of a Vaginal Contraceptive Ring on Vaginal Microbiota and Local Immunity Recruiting NCT02432404 Phase 4 NuvaRing
26 Hormonal Contraceptive Methods on Immunologic Changes in the Female Genital Tract (FGT) and Systemically Recruiting NCT03660046 Phase 4 Depot medroxyprogesterone acetate (DMPA);Etonogestrel implant (Eng-Implant);Levonorgestrel IUD (Lng-IUD)
27 Colposeptine for the Treatment of Bacterial Vaginosis Terminated NCT01153958 Phase 4 Colposeptine;Metronidazole
28 Safety and Efficacy Study of Gynevac Lactobacillus Vaccine in the Treatment of Bacterial Vaginosis Unknown status NCT02173184 Phase 3
29 A Pilot Open-label Randomized Study of Lactofiltrum in Women With Bacterial Vaginosis Unknown status NCT01089348 Phase 2, Phase 3 Lactofiltrum + Metronidazole;Metronidazole
30 The Effect of Probiotics on the Immune Status, Diarrhea and Bacterial Vaginosis Cure Rate Among HIV Patients Unknown status NCT00536848 Phase 2, Phase 3 Metronidazole
31 Va-Sense - Bacterial Vaginosis Once A Week Screening And Treatment To Reduce Infective Complications, Abortion And Preterm Delivery In Pregnant Women With Previous Preterm Delivery Unknown status NCT01152528 Phase 3
32 Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis Unknown status NCT00889356 Phase 3 Clindamycin 100mg and Ketoconazole 400mg;Tetracycline 100mg and Amphotericin B 50mg
33 Bacterial Vaginosis Screening and Treatment to Reduce Infective Complications, Abortion and Preterm Delivery Unknown status NCT00491270 Phase 3
34 Efficacy and Safety Study of Metronidazole, Nystatin and Dexamethasone Combination Therapy in Bacterial and Fungal Vaginal Infections Unknown status NCT02186145 Phase 3 Association of metronidazole; nystatin and dexamethasone;Flagyl
35 Maternal Genitourinary Infections and Adverse Perinatal Outcomes Unknown status NCT01572532 Phase 3
36 Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community Unknown status NCT00124878 Phase 3
37 Bacterial Vaginosis Home Screening to Prevent STDs Completed NCT00667368 Phase 3 Metronidazole
38 Trial of Trimosan Gel Effect on Pessary-associated Bacterial Vaginosis Completed NCT01471457 Phase 2, Phase 3 Trimo-San gel
39 A Phase 3 Study of SPL7013 Gel (VivaGel) for the Treatment of Bacterial Vaginosis Completed NCT01577537 Phase 3 1% SPL7013 Gel;Placebo
40 A Phase 3 Study of SPL7013 Gel (VivaGel) for the Treatment of Bacterial Vaginosis Completed NCT01577238 Phase 3 1% SPL7013 Gel;Placebo
41 Comparative Study of Efficacy of 10 mg Dequalinium Chloride (Fluomizin) in the Local Treatment of Bacterial Vaginosis Completed NCT01125410 Phase 3 Dequalinium chloride;Clindamycin
42 A Phase 3 Study of SYM-1219 Treatment of Women and Post-Menarchal Adolescent Girls With Bacterial Vaginosis Completed NCT02418845 Phase 3 SYM-1219;Placebo
43 Safety and Efficacy Study to Treat Bacterial Vaginosis Completed NCT01621399 Phase 3 Product 55394;Placebo Vehicle (non-treatment)
44 Study Evaluating the Equivalence of GDC-229 and Metronidazole Vaginal Gel 0.75% in the Treatment of Bacterial Vaginosis Completed NCT03091777 Phase 3 GDC-229;Metronidazole Vaginal Gel 0.75%;Placebo
45 Lcr35® for Bacterial Vaginosis Prevention Completed NCT01160796 Phase 3 placebo;Lcr35®
46 Treatment of Bacterial Vaginosis With Oral Tinidazole Completed NCT00229216 Phase 3 Tinidazole
47 Open-Label Study to Evaluate the Safety of A Single Dose of SYM-1219, a Granule Formulation Containing 2 Grams of Secnidazole Completed NCT02452866 Phase 3 SYM-1219
48 Efficacy and Safety Study of SPL7013 Gel to Prevent the Recurrence of Bacterial Vaginosis (BV) Completed NCT02237950 Phase 3 Metronidazole oral tablets 500mg;1% SPL7013 Gel;Placebo gel
49 Efficacy and Safety Study of SPL7013 Gel to Prevent the Recurrence of Bacterial Vaginosis (BV) Completed NCT02236156 Phase 3 Metronidazole oral tablets 500mg;1% SPL7013 Gel;Placebo gel
50 The Impact of Probiotic Bacteria on the Efficacy of Anti-retroviral Therapy and Recurrence of Bacterial Vaginosis Completed NCT01258556 Phase 2, Phase 3

Search NIH Clinical Center for Bacterial Vaginosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: vaginosis, bacterial

Genetic Tests for Bacterial Vaginosis

Anatomical Context for Bacterial Vaginosis

MalaCards organs/tissues related to Bacterial Vaginosis:

41
Colon, Testes, Bone, Skin, Breast, Lung, Heart

Publications for Bacterial Vaginosis

Articles related to Bacterial Vaginosis:

(show top 50) (show all 1067)
# Title Authors Year
1
Reply to letter to editor regarding: Risk of bacterial vaginosis, Trichomonas vaginalis and Candida albicans infection among new users of combined hormonal contraception compared to levonorgestrel-releasing intrauterine system. ( 29323559 )
2018
2
Prevalence of Bacterial Vaginosis and Its Association with Risk Factors among Nonpregnant Women: A Hospital Based Study. ( 29692813 )
2018
3
Correction: Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa: An individual participant data meta-analysis of 18 HIV prevention studies. ( 29944660 )
2018
4
Vaginal Microbiomes Associated With Aerobic Vaginitis and Bacterial Vaginosis. ( 29632854 )
2018
5
Parallel detection of lactobacillus and bacterial vaginosis-associated bacterial DNA in the chorioamnion and vagina of pregnant women at term. ( 29478370 )
2018
6
Are previous episodes of bacterial vaginosis a predictor for vaginal symptoms in breast cancer patients treated with aromatase inhibitors? ( 29409388 )
2018
7
Metatranscriptome Analysis of the Vaginal Microbiota Reveals Potential Mechanisms for Protection against Metronidazole in Bacterial Vaginosis. ( 29875146 )
2018
8
Microbial Culturomics Broadens Human Vaginal Flora Diversity: Genome Sequence and Description of Prevotella lascolaii sp. nov. Isolated from a Patient with Bacterial Vaginosis. ( 29447068 )
2018
9
Serum 25-Hydroxyvitamin D and Risk of Self-Reported Bacterial Vaginosis in a Prospective Cohort Study of Young African American Women. ( 29897832 )
2018
10
Multicenter study establishing the clinical validity of a nucleic-acid amplification-based assay for the diagnosis of bacterial vaginosis. ( 29937222 )
2018
11
A Phase 3, Multicenter, Prospective, Open-Label Study to Evaluate the Safety of a Single Dose of Secnidazole 2a88g for the Treatment of Women and Postmenarchal Adolescent Girls with Bacterial Vaginosis. ( 29323627 )
2018
12
Thymol, eugenol and lactobacilli in a medical device for the treatment of bacterial vaginosis and vulvovaginal candidiasis. ( 29874389 )
2018
13
Use of copper intrauterine device is not associated with higher bacterial vaginosis prevalence in Thai HIV-positive women. ( 29548268 )
2018
14
Combined oral and topical antimicrobial therapy for male partners of women with bacterial vaginosis: Acceptability, tolerability and impact on the genital microbiota of couples - A pilot study. ( 29293559 )
2018
15
Identification of Key Bacteria Involved in the Induction of Incident Bacterial Vaginosis: A Prospective Study. ( 29718358 )
2018
16
Longitudinal trajectory of vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis during pregnancy as well as the impact on pregnancy outcomes: a preliminary study. ( 29685081 )
2018
17
Secnidazole (Solosec) for bacterial vaginosis. ( 29635264 )
2018
18
The Effect of Prangos Ferulacea Vaginal Cream on Accelerating the Recovery of Bacterial Vaginosis: A Randomized Controlled Clinical Trial. ( 29607339 )
2018
19
<i>'Lactobacillus raoultii'</i> sp. nov., a new bacterium isolated from the vaginal flora of a woman with bacterial vaginosis. ( 29204281 )
2018
20
Saccharomyces cerevisiae-based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis. ( 29683763 )
2018
21
Corynebacterium fournierii sp. nov., isolated from the female genital tract of a patient with bacterial vaginosis. ( 29383461 )
2018
22
Bacterial vaginosis modifies the association between hormonal contraception and HIV acquisition. ( 29334545 )
2018
23
Inhibition of sialidase activity and cellular invasion by the bacterial vaginosis pathogen Gardnerella vaginalis. ( 29777255 )
2018
24
The effect of<i>Calendula officinalis</i>versus metronidazole on bacterial vaginosis in women: A double-blind randomized controlled trial. ( 29441319 )
2018
25
Molecular Diagnosis of Bacterial Vaginosis: an Update. ( 29769280 )
2018
26
Secnidazole: next-generation antimicrobial agent for bacterial vaginosis treatment. ( 29327947 )
2018
27
Efficacy and safety of vaginally administered lyophilized Lactobacillus crispatus IP 174178 in the prevention of bacterial vaginosis recurrence. ( 29196153 )
2018
28
Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa: An individual participant data meta-analysis of 18 HIV prevention studies. ( 29485986 )
2018
29
Description of three new Peptoniphilus species cultured in the vaginal fluid of a woman diagnosed with bacterial vaginosis: Peptoniphilus pacaensis sp. nov., Peptoniphilus raoultii sp. nov., and Peptoniphilus vaginalis sp. nov. ( 29931836 )
2018
30
Impact of Standard Bacterial Vaginosis Treatment on the Genital Microbiota, Immune Milieu, and Ex Vivo Human Immunodeficiency Virus Susceptibility. ( 30407498 )
2018
31
Bacterial vaginosis: a primer for clinicians. ( 30424704 )
2018
32
Prevalence of bacterial vaginosis and factors associated among women who have sex with women. ( 30462789 )
2018
33
Laboratory Diagnosis of Bacterial Vaginosis and Potential Pathogens Other Than Group B Streptococcus in Vaginal Swab of Pregnant Women in Dhaka Medical College Hospital. ( 30487502 )
2018
34
Bacterial Vaginosis: An insight into the prevalence, alternative regimen treatments and it's associated resistance patterns. ( 30502515 )
2018
35
The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment: 2018 update. ( 30507674 )
2018
36
Results from a cross-sectional sexual and reproductive health study among school girls in Tanzania: high prevalence of bacterial vaginosis. ( 30518620 )
2018
37
Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial. ( 30525953 )
2018
38
Prevalent Herpes Simplex Virus-2 Increases the Risk of Incident Bacterial Vaginosis in Women from South Africa. ( 28956191 )
2018
39
The effect of prebiotic vaginal gel with adjuvant oral metronidazole tablets on treatment and recurrence of bacterial vaginosis: a triple-blind randomized controlled study. ( 28983665 )
2018
40
Microbial Composition Predicts Genital Tract Inflammation and Persistent Bacterial Vaginosis in South African Adolescent Females. ( 29038128 )
2018
41
Effect of a yoghurt drink containing Lactobacillus strains on bacterial vaginosis in women - a double-blind, randomised, controlled clinical pilot trial. ( 29065710 )
2018
42
Is bacterial vaginosis a disease? ( 29177936 )
2018
43
Prevalence of bacterial vaginosis in pregnant and non-pregnant Iranian women: a systematic review and meta-analysis. ( 29455377 )
2018
44
Reproductive outcome of patients undergoing in vitro fertilisation treatment and diagnosed with bacterial vaginosis or abnormal vaginal microbiota: a systematic PRISMA review and meta-analysis. ( 29469992 )
2018
45
Protein Content of Cervicovaginal Fluid Is Altered During Bacterial Vaginosis. ( 29474232 )
2018
46
Erratum to: "Efficacy and safety of vaginally administered lyophilized Lactobacillus crispatus IP 174178 in the prevention of bacterial vaginosis recurrence" [J. Gynecol. Obstet. Hum. Reprod. 47 (2018) 81-7]. ( 29609764 )
2018
47
Accuracy of a commercial multiplex PCR for the diagnosis of bacterial vaginosis. ( 29985123 )
2018
48
'Helcococcus massiliensis' sp. nov., a new bacterial species isolated from the vaginal sample of a woman with bacterial vaginosis living in Dielmo, Senegal. ( 29997892 )
2018
49
Contraceptive rings promote vaginal lactobacilli in a high bacterial vaginosis prevalence population: A randomised, open-label longitudinal study in Rwandan women. ( 30036385 )
2018
50
Factors in the HIV risk environment associated with bacterial vaginosis among HIV-negative female sex workers who inject drugs in the Mexico-United States border region. ( 30126411 )
2018

Variations for Bacterial Vaginosis

Expression for Bacterial Vaginosis

Search GEO for disease gene expression data for Bacterial Vaginosis.

Pathways for Bacterial Vaginosis

Pathways related to Bacterial Vaginosis according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CXCL8 DEFB4A IL1A IL1B IL6 MBL2
2
Show member pathways
13.39 CXCL8 IL1A IL1B IL6 TLR2 TLR4
3
Show member pathways
13.05 CXCL8 IL1B IL6 TLR2 TLR4 TNF
4
Show member pathways
13.03 CXCL8 IL1B IL6 MBL2 TLR2 TLR4
5
Show member pathways
12.89 CXCL8 IL1A IL1B IL6 PRF1 TNF
6
Show member pathways
12.79 CXCL8 IL1A IL1B IL6 TLR2 TLR4
7
Show member pathways
12.77 CXCL8 IL1B IL6 TLR4 TNF
8
Show member pathways
12.74 IL1A IL1B IL6 TLR2 TLR4 TNF
9
Show member pathways
12.63 IL1A IL1B TLR2 TLR4 TNF
10
Show member pathways
12.63 IL1A IL1B IL6 TLR2 TLR4 TNF
11
Show member pathways
12.42 IL1A IL1B IL6 TNF
12
Show member pathways
12.35 CXCL8 IL1A IL1B IL6 TLR4 TNF
13
Show member pathways
12.35 CXCL8 DEFB4A IL1B IL6 TLR2 TNF
14
Show member pathways
12.32 IL1A IL1B TLR2 TLR4 TNF
15
Show member pathways
12.28 CXCL8 IL1A IL1B IL6 TNF
16
Show member pathways
12.28 CXCL8 IL1A IL6 TLR2 TLR4 TNF
17
Show member pathways
12.24 IL1A IL1B TLR4 TNF
18 12.24 CXCL8 IL1A IL1B IL6 TNF
19 12.24 IL1A IL1B IL6 TLR2 TLR4 TNF
20
Show member pathways
12.22 CXCL8 IL1A IL1B IL6 TLR2 TNF
21
Show member pathways
12.21 CXCL8 IL1A IL1B TLR2 TLR4
22 12.21 IL6 TLR2 TLR4 TNF
23
Show member pathways
12.16 IL1B IL6 TNF
24 12.12 CXCL8 IL1A IL6
25
Show member pathways
12.12 IL1B IL6 TLR2 TLR4 TNF
26
Show member pathways
12.1 IL1B IL6 TLR2 TLR4 TNF
27 12.09 MBL2 TLR2 TLR4
28
Show member pathways
12.07 IL1A IL1B TLR2 TLR4
29 12.05 IL1A IL1B TNF
30 12.05 CXCL8 IL1A IL1B IL6 TNF
31
Show member pathways
12.04 CXCL8 IL1A IL1B IL6
32
Show member pathways
12.02 CXCL8 DEFB4A IL1B IL6 TLR2 TLR4
33 12.01 IL1A IL1B TNF
34 11.99 CXCL8 IL1A IL1B IL6
35 11.99 CXCL8 IL1A IL1B IL6 TLR4 TNF
36 11.96 CXCL8 IL1A IL1B IL6 TNF
37 11.95 IL1A IL1B IL6 TNF
38 11.94 IL1B IL6 TNF
39 11.94 CXCL8 IL1B TLR4 TNF
40 11.88 CXCL8 IL1A IL1B IL6 TLR4
41
Show member pathways
11.87 CXCL8 IL6 TLR4
42 11.83 CXCL8 IL1B IL6 TLR2 TLR4 TNF
43 11.77 IL1B IL6 TNF
44 11.75 CXCL8 IL1B IL6 TNF
45 11.74 IL1B IL6 TNF
46 11.68 CXCL8 IL1A IL1B IL6 TLR4 TNF
47
Show member pathways
11.67 CXCL8 IL1A IL1B IL6 TNF
48 11.62 IL1A TLR4 TNF
49 11.6 IL1B TLR2 TLR4 TNF
50 11.57 IL1A IL1B IL6 TNF

GO Terms for Bacterial Vaginosis

Cellular components related to Bacterial Vaginosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CXCL8 DEFB4A IL1A IL1B IL6 MBL2
2 extracellular region GO:0005576 9.23 CXCL8 DEFB4A IL1A IL1B IL6 MBL2

Biological processes related to Bacterial Vaginosis according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 IL1A IL1B IL6 TLR2 TLR4 TNF
2 defense response to bacterium GO:0042742 9.94 DEFB4A MBL2 TLR4 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.93 CXCL8 IL1A IL1B IL6 TNF
4 response to lipopolysaccharide GO:0032496 9.9 IL1B TLR2 TLR4
5 positive regulation of angiogenesis GO:0045766 9.89 CXCL8 IL1A IL1B
6 defense response GO:0006952 9.89 CXCL8 DEFB4A TNF
7 cellular response to lipopolysaccharide GO:0071222 9.88 CXCL8 IL1B IL6 TLR4 TNF
8 activation of MAPK activity GO:0000187 9.87 IL1B TLR4 TNF
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.87 IL1B IL6 TNF
10 defense response to Gram-negative bacterium GO:0050829 9.85 DEFB4A IL6 TLR4
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TLR2 TLR4 TNF
12 positive regulation of JNK cascade GO:0046330 9.84 IL1B TLR4 TNF
13 positive regulation of inflammatory response GO:0050729 9.84 TLR2 TLR4 TNF
14 response to glucocorticoid GO:0051384 9.81 IL1B IL6 TNF
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 IL1B TLR2 TLR4 TNF
16 positive regulation of interferon-gamma production GO:0032729 9.79 IL1B TLR4 TNF
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IL1B TLR4 TNF
18 positive regulation of phagocytosis GO:0050766 9.75 IL1B MBL2 TNF
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.74 IL1A IL1B TNF
20 positive regulation of interleukin-12 production GO:0032735 9.73 TLR2 TLR4
21 positive regulation of interleukin-10 production GO:0032733 9.72 TLR2 TLR4
22 positive regulation of neutrophil chemotaxis GO:0090023 9.72 CXCL8 IL1B
23 negative regulation of neurogenesis GO:0050768 9.72 IL1B IL6 TNF
24 defense response to Gram-positive bacterium GO:0050830 9.72 DEFB4A IL6 MBL2 TLR2 TNF
25 microglial cell activation GO:0001774 9.71 TLR2 TNF
26 embryonic digestive tract development GO:0048566 9.71 CXCL8 TNF
27 negative regulation of lipid catabolic process GO:0050995 9.71 IL1B TNF
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.71 IL1B TNF
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 IL1B TNF
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL1B TLR2 TLR4 TNF
31 negative regulation of growth of symbiont in host GO:0044130 9.7 MBL2 TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 IL1B TNF
33 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.7 TLR2 TLR4
34 positive regulation of glial cell proliferation GO:0060252 9.7 IL1B IL6 TNF
35 inflammatory response GO:0006954 9.7 CXCL8 IL1A IL1B IL6 TLR2 TLR4
36 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.69 IL1A IL1B
37 regulation of cytokine secretion GO:0050707 9.69 TLR2 TLR4
38 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
39 response to molecule of bacterial origin GO:0002237 9.68 CXCL8 TLR2
40 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 TLR4
41 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR4 TNF
42 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
43 positive regulation of interleukin-8 production GO:0032757 9.67 IL1B TLR2 TLR4 TNF
44 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
45 ectopic germ cell programmed cell death GO:0035234 9.65 IL1A IL1B
46 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
47 positive regulation of fever generation GO:0031622 9.63 IL1B TNF
48 chronic inflammatory response to antigenic stimulus GO:0002439 9.63 IL1B TNF
49 sequestering of triglyceride GO:0030730 9.62 IL1B TNF
50 positive regulation of neuroinflammatory response GO:0150078 9.61 IL1B IL6 TNF

Molecular functions related to Bacterial Vaginosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1A IL1B
2 cytokine activity GO:0005125 9.02 CXCL8 IL1A IL1B IL6 TNF
3 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4

Sources for Bacterial Vaginosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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