MCID: BLN010
MIFTS: 35

Balanitis

Categories: Reproductive diseases

Aliases & Classifications for Balanitis

Summaries for Balanitis

MalaCards based summary : Balanitis is related to balanitis xerotica obliterans and leukoplakia of penis. An important gene associated with Balanitis is TGM2 (Transglutaminase 2). The drugs Sevoflurane and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and bone marrow, and related phenotype is behavior/neurological.

Wikipedia : 77 Balanitis is inflammation of the glans penis. When the foreskin is also affected, it is termed... more...

Related Diseases for Balanitis

Diseases related to Balanitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 balanitis xerotica obliterans 33.6 TGM1 TGM2 TGM3
2 leukoplakia of penis 11.6
3 lichen sclerosus 11.5
4 balanoposthitis 11.5
5 phimosis 11.4
6 lichen sclerosus et atrophicus 11.4
7 peyronie's disease 11.1
8 hypospadias 10.8
9 squamous cell carcinoma 10.2
10 vulvitis 10.2
11 penile cancer, adult 10.2
12 urethral stricture 10.2
13 erythroplakia 10.2
14 vulvovaginitis 10.1
15 verrucous carcinoma 10.1
16 syphilis 10.1
17 autoimmune disease of skin and connective tissue 10.0 TGM2 TGM3
18 arthritis 10.0
19 necrobiosis lipoidica 10.0
20 reactive arthritis 10.0
21 herpes simplex 10.0
22 fixed drug eruption 10.0
23 juvenile ankylosing spondylitis 9.9 MRAP PHB2
24 iritis 9.9 MRAP PHB2
25 enthesopathy 9.9 MRAP PHB2
26 bursitis 9.9 MRAP PHB2
27 dermatitis herpetiformis 9.9 TGM2 TGM3
28 urethritis 9.9 MRAP PHB2
29 tendinitis 9.9 MRAP PHB2
30 ige responsiveness, atopic 9.9
31 neutrophil migration 9.9
32 leukemia, acute lymphoblastic 9.9
33 acute lymphocytic leukemia 9.9
34 leukemia 9.9
35 lymphocytic leukemia 9.9
36 cicatricial pemphigoid 9.9
37 telangiectasis 9.9
38 paronychia 9.9
39 uveitis 9.9
40 cystitis 9.9
41 vaginitis 9.9
42 gingivitis 9.9
43 proctitis 9.9
44 fibrosarcoma 9.9
45 primary syphilis 9.9
46 hyperglycemia 9.9
47 adenosquamous carcinoma 9.9
48 human immunodeficiency virus infectious disease 9.9
49 conjunctivitis 9.9
50 herpes zoster 9.9

Graphical network of the top 20 diseases related to Balanitis:



Diseases related to Balanitis

Symptoms & Phenotypes for Balanitis

MGI Mouse Phenotypes related to Balanitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 PHB2 SLC5A2 TGM1 TGM2 TGM3

Drugs & Therapeutics for Balanitis

Drugs for Balanitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
2
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
3
Bupivacaine Approved, Investigational Phase 1 38396-39-3, 2180-92-9 2474
4
Ibuprofen Approved Phase 1 15687-27-1 3672
5
Acetaminophen Approved Phase 1 103-90-2 1983
6 Antirheumatic Agents Phase 1
7 Antipyretics Phase 1
8 Analgesics Phase 1
9 Cyclooxygenase Inhibitors Phase 1
10 Platelet Aggregation Inhibitors Phase 1
11 Anesthetics Phase 1
12 Anesthetics, Local Phase 1
13 Central Nervous System Depressants Phase 1
14 Anti-Inflammatory Agents Phase 1,Not Applicable
15 Peripheral Nervous System Agents Phase 1
16 Ketorolac Tromethamine Phase 1
17 Anti-Inflammatory Agents, Non-Steroidal Phase 1
18 Analgesics, Non-Narcotic Phase 1
19 Anesthetics, General Phase 1
20 Anesthetics, Inhalation Phase 1
21 Anti-Infective Agents Phase 1
22
Adenosine Approved, Investigational 58-61-7 60961
23
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
24
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
25 Hormone Antagonists Not Applicable
26 Triamcinolone hexacetonide Not Applicable
27 Immunosuppressive Agents Not Applicable
28 Immunologic Factors Not Applicable
29 glucocorticoids Not Applicable
30 retinol Not Applicable
31 Retinol palmitate Not Applicable
32 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
33 Hormones Not Applicable
34 Triamcinolone diacetate Not Applicable
35 triamcinolone acetonide Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
2 Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand Completed NCT00213057 Phase 1 Carraguard (PC-515)
3 Susceptibility Genes in Autism Spectrum Disorders Unknown status NCT02628808
4 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable
5 Features and Outcomes of Patients With Reactive Arthritis Completed NCT03926429

Search NIH Clinical Center for Balanitis

Cochrane evidence based reviews: balanitis

Genetic Tests for Balanitis

Anatomical Context for Balanitis

MalaCards organs/tissues related to Balanitis:

42
Bone, Skin, Bone Marrow, T Cells, Neutrophil

Publications for Balanitis

Articles related to Balanitis:

(show top 50) (show all 327)
# Title Authors Year
1
Zoon Balanitis in an immune-competent teenager. ( 28895662 )
2019
2
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. ( 30130825 )
2019
3
Accuracy of dermoscopy in distinguishing erythroplasia of Queyrat from common forms of chronic balanitis: results from a multicentric observational study. ( 30468529 )
2019
4
Syphilitic balanitis of Follmann: two case reports. ( 30471083 )
2019
5
Topical mupirocin 2% ointment for diagnosis of Zoon's balanitis and monotherapy of balanitis circumscripta plasmacellularis. ( 30604433 )
2019
6
Surgical managements of pseudoepitheliomatous keratotic and micaceous balanitis: A case report. ( 30684817 )
2019
7
Re: Single-Stage Urethroplasty with Buccal Mucosal Inlay Graft for Stricture Caused by Balanitis Xerotica Obliterans in Boys: . ( 30759653 )
2019
8
Pseudo circinate balanitis: great masquerader lives. ( 30808720 )
2019
9
A case-control study of risk factors associated with Zoon balanitis in men. ( 30903714 )
2019
10
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. ( 29150196 )
2018
11
Balanitis associated with FOLFIRI chemotherapy. ( 29387750 )
2018
12
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
13
Handheld reflectance confocal microscopy, dermatoscopy and histopathological correlation of common inflammatory balanitis. ( 29457262 )
2018
14
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. ( 29534008 )
2018
15
Syphilitic balanitis of Follmann. ( 29564878 )
2018
16
Candida Balanitis with Hyperplastic Plaque Mimicking Vascular Neoplasm. ( 29722348 )
2018
17
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). ( 29974722 )
2018
18
Balanitis circinata. ( 30071931 )
2018
19
Zoon's plasma cell balanitis: clinical and dermoscopic features in pediatric patients. ( 30117600 )
2018
20
Balanitis in Acute Lymphoblastic Leukemia: A Rare Etiology and Unusual Presentation. ( 30127570 )
2018
21
Circumcision is still the gold standard in management of plasma cell balanitis. ( 30246920 )
2018
22
Balanitis xerotica obliterans: a review of diagnosis and management. ( 30315576 )
2018
23
Thalidomide in plasma cell balanitis refractory to conventional topical treatment. ( 30484535 )
2018
24
Reflectance confocal microscopy as a noninvasive complementary tool in the diagnosis of psoriatic balanitis. ( 27514619 )
2017
25
Streptococcus pyogenes as the cause of vulvovaginitis and balanitis in children. ( 27638252 )
2017
26
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). ( 28043767 )
2017
27
Circinate Balanitis. ( 28076706 )
2017
28
Recurrence after management of meatal balanitis xerotica obliterans. ( 28089110 )
2017
29
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. ( 28089293 )
2017
30
Zoon Balanitis Revisited: Report of Balanitis Circumscripta Plasmacellularis Resolving With Topical Mupirocin Ointment Monotherapy. ( 28301626 )
2017
31
Successful Management of Zoon's Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris. ( 28382428 )
2017
32
Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5-fluorouracil and liquid nitrogen. ( 28406530 )
2017
33
Erratum to: Successful Management of Zoon's Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacellularis. ( 28425049 )
2017
34
Zoon's balanitis treated with topical tacrolimus. ( 28479782 )
2017
35
Balanitis xerotica obliterans: has its diagnostic accuracy improved with time? ( 28620502 )
2017
36
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
37
Image Gallery: Generalized circinate cutaneous lesions simulating circinate balanitis. ( 29192976 )
2017
38
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. ( 29234536 )
2017
39
Balanitis: A Unique Presentation of Diabetes in an Elderly Male. ( 29467066 )
2017
40
Dermoscopy in plasma cell balanitis: its usefulness in diagnosis and follow-up. ( 25176141 )
2016
41
Zoon's balanitis successfully treated with photodynamic therapy: Case report and literature review. ( 26321748 )
2016
42
Dermoscopy of Zoon's plasma cell balanitis. ( 26670716 )
2016
43
The clinical spectrum of syphilitic balanitis of Follmann: report of five cases and a review of the literature. ( 27421838 )
2016
44
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. ( 27649154 )
2016
45
Contact balanitis to tromantadine. ( 27757977 )
2016
46
Zoon balanitis: A comprehensive review. ( 27890945 )
2016
47
Clinical study of the effectiveness of the "water of the 3 sulfates" on balanitis and balanoposthitis. ( 25262388 )
2015
48
Treatment of pseudoepitheliomatous, keratotic, and micaceous balanitis with topical photodynamic therapy. ( 25266766 )
2015
49
Balanitis is a risk factor for herpes zoster. ( 25596845 )
2015
50
Circinate balanitis as the presenting symptom of sexually-acquired reactive arthritis: a case report. ( 25918330 )
2015

Variations for Balanitis

Expression for Balanitis

Search GEO for disease gene expression data for Balanitis.

Pathways for Balanitis

GO Terms for Balanitis

Cellular components related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 8.92 SLC5A2 TGM1 TGM2 TGM3

Biological processes related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.32 TGM1 TGM3
2 cellular protein modification process GO:0006464 9.26 TGM1 TGM3
3 keratinocyte differentiation GO:0030216 9.16 TGM1 TGM3
4 cell envelope organization GO:0043163 8.96 TGM1 TGM3
5 peptide cross-linking GO:0018149 8.8 TGM1 TGM2 TGM3

Molecular functions related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring acyl groups GO:0016746 9.13 TGM1 TGM2 TGM3
2 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM1 TGM2 TGM3

Sources for Balanitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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