MCID: BLN010
MIFTS: 36

Balanitis

Categories: Reproductive diseases

Aliases & Classifications for Balanitis

Summaries for Balanitis

MalaCards based summary : Balanitis is related to balanitis xerotica obliterans and balanoposthitis. An important gene associated with Balanitis is TGM2 (Transglutaminase 2), and among its related pathways/superpathways are NRF2 pathway and Hexose transport. The drugs Empagliflozin and Sodium-Glucose Transporter 2 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and tongue, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Balanitis is inflammation of the glans penis. When the foreskin is also affected, it is termed... more...

Related Diseases for Balanitis

Diseases related to Balanitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 balanitis xerotica obliterans 33.8 TGM3 TGM2 TGM1 ECM1
2 balanoposthitis 31.0 SLC5A4 SLC5A2 SLC5A1 ILVBL DPP4
3 vulvitis 30.5 SLC5A4 SLC5A2 ILVBL
4 urethritis 30.3 MRAP CRP
5 syphilis 30.2 MRAP CRP
6 penile disease 30.2 SLC5A4 SLC5A2 MRAP
7 vulvovaginitis 29.8 SLC5A4 SLC5A2 SLC5A1 ILVBL
8 cellulitis 29.5 TGM2 CRP
9 hyperglycemia 29.1 SLC5A2 SLC5A1 DPP4
10 skin disease 28.2 TGM3 TGM1 ECM1 DPP4 CRP
11 acute cystitis 28.2 SLC5A4 SLC5A2 REG1A DPP4 CRP
12 leukoplakia of penis 11.7
13 phimosis 11.6
14 lichen sclerosus et atrophicus 11.6
15 peyronie's disease 11.2
16 hypospadias 10.6
17 urethral stricture 10.4
18 erythroplakia 10.4
19 verrucous carcinoma 10.3
20 testicular leydig cell tumor 10.3 SLC5A4 SLC5A2
21 squamous cell carcinoma 10.3
22 in situ carcinoma 10.3
23 fanconi-like syndrome 10.2 SLC5A2 SLC5A1
24 primary syphilis 10.2
25 reactive arthritis 10.2
26 dermatitis herpetiformis 10.2 TGM3 TGM2 TGM1
27 mucositis 10.2
28 penile cancer 10.2
29 candidiasis 10.2
30 keratosis 10.2
31 impotence 10.2
32 paraphimosis 10.2
33 conjunctivitis 10.2
34 lichen planus 10.2
35 malignant tumor of penis 10.2
36 gastroduodenal crohn's disease 10.1 TGM2 CRP
37 pineal region meningioma 10.1 TGM3 CRP
38 duodenitis 10.1 TGM2 CRP
39 large intestine lipoma 10.1 TGM1 CRP
40 lipoma of colon 10.1 TGM1 CRP
41 specific bursitis often of occupational origin 10.1 MRAP CRP
42 bursitis 10.1 MRAP CRP
43 chronic orbital inflammation 10.1 MRAP CRP
44 anterior scleritis 10.1 MRAP CRP
45 scleritis 10.1 MRAP CRP
46 posterior scleritis 10.1 MRAP CRP
47 olecranon bursitis 10.1 MRAP CRP
48 telangiectasis 10.1
49 cystitis 10.1
50 papilloma 10.1

Graphical network of the top 20 diseases related to Balanitis:



Diseases related to Balanitis

Symptoms & Phenotypes for Balanitis

MGI Mouse Phenotypes related to Balanitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 CRP DPP4 MRAP REG1A SLC5A1 SLC5A2

Drugs & Therapeutics for Balanitis

Drugs for Balanitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Empagliflozin Approved Phase 4 864070-44-0
2 Sodium-Glucose Transporter 2 Inhibitors Phase 4
3 Hypoglycemic Agents Phase 4
4
Acetaminophen Approved Phase 1 103-90-2 1983
5
Ibuprofen Approved Phase 1 15687-27-1 3672
6
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
7
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
8
Bupivacaine Approved, Investigational Phase 1 38396-39-3, 2180-92-9 2474
9 Anti-Infective Agents Phase 1
10 Anti-Inflammatory Agents Phase 1
11 Anesthetics, Local Phase 1
12 Platelet Aggregation Inhibitors Phase 1
13 Anti-Inflammatory Agents, Non-Steroidal Phase 1
14 Antipyretics Phase 1
15 Anesthetics, General Phase 1
16 Analgesics, Non-Narcotic Phase 1
17 Cyclooxygenase Inhibitors Phase 1
18 Anesthetics, Inhalation Phase 1
19 Ketorolac Tromethamine Phase 1
20 Antirheumatic Agents Phase 1
21 Central Nervous System Depressants Phase 1
22 Analgesics Phase 1
23
Triamcinolone Approved, Vet_approved 124-94-7 31307
24
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
25 Immunologic Factors
26 retinol
27 Retinol palmitate
28 Hormone Antagonists
29 Triamcinolone diacetate
30 Triamcinolone hexacetonide
31 triamcinolone acetonide
32 glucocorticoids
33 Hormones
34 Immunosuppressive Agents
35 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation: A Randomised Double-blind Placebo-controlled Trial (The SEESAW Study) Recruiting NCT02798744 Phase 4 Empagliflozin;Placebo
2 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety and Acceptability of Carraguard™ (PC-515) Vaginal Gel Among Heterosexual Couples in Chiang Rai Completed NCT00213057 Phase 1 Carraguard (PC-515)
3 A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
4 A Bicentre Retrospective Study of Features and Outcomes of Patients With Reactive Arthritis Completed NCT03926429
5 Circumcision Versus Preputioplasty for BXO in Children: A Feasibility Randomised Controlled Trial Completed NCT02854995
6 A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of the Dominican Republic (DR) Completed NCT02337179
7 Evaluation of the ShangRing vs. Mogen Clamp for Early Infant Male Circumcision (EIMC) in Sub-Saharan Africa Recruiting NCT03338699

Search NIH Clinical Center for Balanitis

Cochrane evidence based reviews: balanitis

Genetic Tests for Balanitis

Anatomical Context for Balanitis

MalaCards organs/tissues related to Balanitis:

40
Skin, Bone, Tongue, Kidney, Testes, Bone Marrow, Lymph Node

Publications for Balanitis

Articles related to Balanitis:

(show top 50) (show all 735)
# Title Authors PMID Year
1
A Rare Cause of a Scrotal Abscess due to the Symbiotic Infection of Gardnerella vaginalis and Prevotella bivia in an Adult Male. 61
32024139 2020
2
Tissue engineered indigenous pericardial patch urethroplasty: A promising solution to a nagging problem. 61
31970073 2020
3
Balanitis xerotica obliterans: an update for clinicians. 61
31760506 2020
4
Pseudoepitheliomatous, Keratotic, and Micaceous Balanitis. 61
31921499 2020
5
Successful treatment of micaceous balanitis with 5% topical imiquimod: case report and review of the literature. 61
31846060 2019
6
Rituximab as most adequate treatment option for CD20-positive balanitis plasmacellularis Zoon! 61
31664744 2019
7
Persistent Mü̈llerian duct syndrome in a beluga whale Delphinapterus leucas. 61
31724560 2019
8
Zoon balanitis - does it exist? 61
31660645 2019
9
Zoon Balanitis: misdiagnosis or missed diagnosis? 61
31660642 2019
10
Save the foreskin: Outcomes of preputioplasty in the treatment of childhood phimosis. 61
31548120 2019
11
A case-control study of risk factors associated with Zoon balanitis in men. 61
30903714 2019
12
Ultrasound evidence of bladder outlet obstruction secondary to lichen sclerosus et atrophicus in boys (balanitis xerotica obliterans). 61
31455543 2019
13
Balanitis xerotica obliterans: a review of diagnosis and management. 61
30315576 2019
14
A tale of an acute erosive balanitis. 61
31383382 2019
15
Penile Horn: A Rare Presentation of Pseudoepitheliomatous, Keratotic, and Micaceous Balanitis Successfully Treated with Oral Acitretin. 61
31334071 2019
16
In situ squamous cell carcinoma of male and female external genitalia. 61
31922109 2019
17
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. 61
30130825 2019
18
Topical mupirocin 2% ointment for diagnosis of Zoon's balanitis and monotherapy of balanitis circumscripta plasmacellularis. 61
30604433 2019
19
Pseudo circinate balanitis: great masquerader lives. 61
30808720 2019
20
Accuracy of dermoscopy in distinguishing erythroplasia of Queyrat from common forms of chronic balanitis: results from a multicentric observational study. 61
30468529 2019
21
Zoon Balanitis in an immune-competent teenager. 61
28895662 2019
22
Syphilitic balanitis of Follmann: two case reports. 61
30471083 2019
23
Re: Single-Stage Urethroplasty with Buccal Mucosal Inlay Graft for Stricture Caused by Balanitis Xerotica Obliterans in Boys: . 61
30759653 2019
24
Penile cancer epidemiology and risk factors: a contemporary review. 61
30562185 2019
25
Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012. 61
30426132 2019
26
Empagliflozin in posttransplantation diabetes mellitus: A prospective, interventional pilot study on glucose metabolism, fluid volume, and patient safety. 61
30585690 2019
27
Comparative risk of genital infections associated with sodium-glucose co-transporter-2 inhibitors. 61
30207042 2019
28
Urogenital infections in patients with diabetes mellitus: Beyond the conventional aspects. 61
32031031 2019
29
Surgical managements of pseudoepitheliomatous keratotic and micaceous balanitis: A case report. 61
30684817 2019
30
A Case of Squamous Cell Carcinoma of the Anterior Urethra in a Man. 61
31768143 2019
31
Prepuce sparing: Use of Z-plasty for treatment of phimosis and scarred foreskin. 61
29909192 2018
32
Balanitis circinata. 61
30071931 2018
33
Abnormal dartos fascia in buried penis and hypospadias: Evidence from histopathology. 61
30554609 2018
34
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. 61
29395150 2018
35
Circumcision is still the gold standard in management of plasma cell balanitis. 61
30246920 2018
36
Zoon's plasma cell balanitis: clinical and dermoscopic features in pediatric patients. 61
30117600 2018
37
Thalidomide in plasma cell balanitis refractory to conventional topical treatment. 61
30484535 2018
38
Handheld reflectance confocal microscopy, dermatoscopy and histopathological correlation of common inflammatory balanitis. 61
29457262 2018
39
[Correlation between the genotypes and clinical symptoms of human papilloma virus in male outpatients at STD clinics]. 61
30173432 2018
40
High variability within Candida albicans transcription factor RLM1: Isolates from vulvovaginal infections show a clear bias toward high molecular weight alleles. 61
29420774 2018
41
Balanitis in Acute Lymphoblastic Leukemia: A Rare Etiology and Unusual Presentation. 61
30127570 2018
42
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). 61
29974722 2018
43
Candida Balanitis with Hyperplastic Plaque Mimicking Vascular Neoplasm. 61
29722348 2018
44
Routine histopathological examination of the foreskin after circumcision for clinically suspected lichen sclerosus in children: Is it a waste of resources? 61
29405913 2018
45
Benefits of Urologic-Dermatologic Consultations for the Diagnosis of Cutaneous Penile Lesions: A Prospective Study. 61
29079166 2018
46
Syphilitic balanitis of Follmann. 61
29564878 2018
47
[Dermato-urology: Male genital lesions urologist should know]. 61
29428190 2018
48
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. 61
29534008 2018
49
Nonvenereal Penile Dermatoses: A Retrospective Study. 61
29644193 2018
50
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. 61
29150196 2018

Variations for Balanitis

Expression for Balanitis

Search GEO for disease gene expression data for Balanitis.

Pathways for Balanitis

Pathways related to Balanitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 SLC5A4 SLC5A2 SLC5A1
2
Show member pathways
10.8 SLC5A4 SLC5A2 SLC5A1

GO Terms for Balanitis

Cellular components related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.23 TGM3 TGM2 TGM1 SLC5A2 SLC5A1 REG1A

Biological processes related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 9.43 SLC5A4 SLC5A2 SLC5A1
2 carbohydrate transport GO:0008643 9.32 SLC5A2 SLC5A1
3 cell envelope organization GO:0043163 9.16 TGM3 TGM1
4 peptide cross-linking GO:0018149 9.13 TGM3 TGM2 TGM1
5 glucose transmembrane transport GO:1904659 8.8 SLC5A4 SLC5A2 SLC5A1

Molecular functions related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane transporter activity GO:0022857 9.43 SLC5A4 SLC5A2 SLC5A1
2 transferase activity, transferring acyl groups GO:0016746 9.33 TGM3 TGM2 TGM1
3 protein-glutamine gamma-glutamyltransferase activity GO:0003810 9.13 TGM3 TGM2 TGM1
4 glucose:sodium symporter activity GO:0005412 8.8 SLC5A4 SLC5A2 SLC5A1

Sources for Balanitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....