MCID: BLN010
MIFTS: 34

Balanitis

Categories: Reproductive diseases

Aliases & Classifications for Balanitis

Summaries for Balanitis

MalaCards based summary : Balanitis is related to balanitis xerotica obliterans and leukoplakia of penis. An important gene associated with Balanitis is TGM2 (Transglutaminase 2). The drugs Bupivacaine and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and t cells, and related phenotype is behavior/neurological.

Wikipedia : 76 Balanitis is inflammation of the glans penis. When the foreskin is also affected, it is termed... more...

Related Diseases for Balanitis

Diseases related to Balanitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 balanitis xerotica obliterans 33.6 TGM1 TGM2 TGM3
2 leukoplakia of penis 11.6
3 lichen sclerosus 11.4
4 balanoposthitis 11.4
5 phimosis 11.4
6 lichen sclerosus et atrophicus 11.4
7 peyronie's disease 11.1
8 hypospadias 10.7
9 squamous cell carcinoma 10.2
10 vulvitis 10.2
11 penile cancer, adult 10.2
12 urethral stricture 10.1
13 verrucous carcinoma 10.1
14 autoimmune disease of skin and connective tissue 10.0 TGM2 TGM3
15 arthritis 10.0
16 vulvovaginitis 10.0
17 necrobiosis lipoidica 10.0
18 syphilis 10.0
19 reactive arthritis 10.0
20 herpes simplex 10.0
21 erythroplakia 10.0
22 fixed drug eruption 10.0
23 juvenile ankylosing spondylitis 10.0 MRAP PHB2
24 iritis 10.0 MRAP PHB2
25 enthesopathy 9.9 MRAP PHB2
26 bursitis 9.9 MRAP PHB2
27 urethritis 9.9 MRAP PHB2
28 tendinitis 9.9 MRAP PHB2
29 dermatitis herpetiformis 9.9 TGM2 TGM3
30 transient arthritis 9.9 MRAP PHB2
31 urethral syndrome 9.9 MRAP PHB2
32 leukemia, acute lymphoblastic 9.8
33 acute lymphocytic leukemia 9.8
34 leukemia 9.8
35 lymphocytic leukemia 9.8
36 cicatricial pemphigoid 9.8
37 telangiectasis 9.8
38 paronychia 9.8
39 uveitis 9.8
40 cystitis 9.8
41 vaginitis 9.8
42 gingivitis 9.8
43 proctitis 9.8
44 fibrosarcoma 9.8
45 primary syphilis 9.8
46 hyperglycemia 9.8
47 adenosquamous carcinoma 9.8
48 human immunodeficiency virus infectious disease 9.8
49 conjunctivitis 9.8
50 herpes zoster 9.8

Graphical network of the top 20 diseases related to Balanitis:



Diseases related to Balanitis

Symptoms & Phenotypes for Balanitis

MGI Mouse Phenotypes related to Balanitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.02 PHB2 SLC5A2 TGM1 TGM2 TGM3

Drugs & Therapeutics for Balanitis

Drugs for Balanitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
2
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
3
Ibuprofen Approved Phase 1 15687-27-1 3672
4
Ketorolac Approved Phase 1 66635-83-4, 74103-06-3 3826
5
Acetaminophen Approved Phase 1 103-90-2 1983
6 Anesthetics, Inhalation Phase 1
7 Central Nervous System Depressants Phase 1
8 Antipyretics Phase 1
9 Cyclooxygenase Inhibitors Phase 1
10 Peripheral Nervous System Agents Phase 1
11 Ketorolac Tromethamine Phase 1
12 Analgesics Phase 1
13 Anti-Inflammatory Agents Phase 1,Not Applicable
14 Anti-Inflammatory Agents, Non-Steroidal Phase 1
15 Anesthetics Phase 1
16 Analgesics, Non-Narcotic Phase 1
17 Platelet Aggregation Inhibitors Phase 1
18 Anesthetics, Local Phase 1
19 Anesthetics, General Phase 1
20 Antirheumatic Agents Phase 1
21 Anti-Infective Agents Phase 1
22
Adenosine Approved, Investigational 58-61-7 60961
23
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
24
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
25 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
26 Triamcinolone diacetate Not Applicable
27 Immunosuppressive Agents Not Applicable
28 Hormone Antagonists Not Applicable
29 Retinol palmitate Not Applicable
30 triamcinolone acetonide Not Applicable
31 retinol Not Applicable
32 Immunologic Factors Not Applicable
33 Hormones Not Applicable
34 glucocorticoids Not Applicable
35 Triamcinolone hexacetonide Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
2 Safety and Acceptability of Carraguard™ Among HIV-negative Couples in Thailand Completed NCT00213057 Phase 1 Carraguard (PC-515)
3 Susceptibility Genes in Autism Spectrum Disorders Unknown status NCT02628808
4 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable

Search NIH Clinical Center for Balanitis

Cochrane evidence based reviews: balanitis

Genetic Tests for Balanitis

Anatomical Context for Balanitis

MalaCards organs/tissues related to Balanitis:

41
Bone, Skin, T Cells, Bone Marrow

Publications for Balanitis

Articles related to Balanitis:

(show top 50) (show all 322)
# Title Authors Year
1
Candida Balanitis with Hyperplastic Plaque Mimicking Vascular Neoplasm. ( 29722348 )
2018
2
Syphilitic balanitis of Follmann. ( 29564878 )
2018
3
Handheld reflectance confocal microscopy, dermatoscopy and histopathological correlation of common inflammatory balanitis. ( 29457262 )
2018
4
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
5
Balanitis associated with FOLFIRI chemotherapy. ( 29387750 )
2018
6
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. ( 29534008 )
2018
7
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). ( 29974722 )
2018
8
Balanitis circinata. ( 30071931 )
2018
9
Zoon's plasma cell balanitis: clinical and dermoscopic features in pediatric patients. ( 30117600 )
2018
10
Balanitis in Acute Lymphoblastic Leukemia: A Rare Etiology and Unusual Presentation. ( 30127570 )
2018
11
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. ( 30130825 )
2018
12
Circumcision is still the gold standard in management of plasma cell balanitis. ( 30246920 )
2018
13
Balanitis xerotica obliterans: a review of diagnosis and management. ( 30315576 )
2018
14
Accuracy of dermoscopy in distinguishing erythroplasia of Queyrat from common forms of chronic balanitis: results from a multicentric observational study. ( 30468529 )
2018
15
Syphilitic balanitis of Follmann: two case reports. ( 30471083 )
2018
16
Thalidomide in plasma cell balanitis refractory to conventional topical treatment. ( 30484535 )
2018
17
Image Gallery: Generalized circinate cutaneous lesions simulating circinate balanitis. ( 29192976 )
2017
18
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. ( 29234536 )
2017
19
Circinate Balanitis. ( 28076706 )
2017
20
Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5-fluorouracil and liquid nitrogen. ( 28406530 )
2017
21
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. ( 29150196 )
2017
22
Zoon's balanitis treated with topical tacrolimus. ( 28479782 )
2017
23
Balanitis: A Unique Presentation of Diabetes in an Elderly Male. ( 29467066 )
2017
24
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
25
Zoon Balanitis Revisited: Report of Balanitis Circumscripta Plasmacellularis Resolving With Topical Mupirocin Ointment Monotherapy. ( 28301626 )
2017
26
A case of Zoon Balanitis in an immune-competent teenager. ( 28895662 )
2017
27
Balanitis xerotica obliterans: has its diagnostic accuracy improved with time? ( 28620502 )
2017
28
Successful Management of Zoon's Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacelluaris. ( 28382428 )
2017
29
Reflectance confocal microscopy as a noninvasive complementary tool in the diagnosis of psoriatic balanitis. ( 27514619 )
2017
30
Erratum to: Successful Management of Zoon's Balanitis with Topical Mupirocin Ointment: A Case Report and Literature Review of Mupirocin-Responsive Balanitis Circumscripta Plasmacellularis. ( 28425049 )
2017
31
Streptococcus pyogenes as the cause of vulvovaginitis and balanitis in children from Nis, Serbia. ( 27638252 )
2016
32
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. ( 27649154 )
2016
33
Zoon balanitis: A comprehensive review. ( 27890945 )
2016
34
The clinical spectrum of syphilitic balanitis of Follmann: report of five cases and a review of the literature. ( 27421838 )
2016
35
Contact balanitis to tromantadine. ( 27757977 )
2016
36
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. ( 28089293 )
2016
37
Recurrence after management of meatal balanitis xerotica obliterans. ( 28089110 )
2016
38
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). ( 28043767 )
2016
39
Pseudoepitheliomatous, Keratotic and Micaceous Balanitis: A Case Report. ( 26557598 )
2015
40
ZOON's BALANITIS SUCCESSFULLY TREATED WITH PHOTODYNAMIC THERAPY: CASE REPORT AND LITERATURE REVIEW. ( 26321748 )
2015
41
Reiter's disease: Circinate balanitis as alone preceding presentation - Successfully treated with pimecrolimus 1% cream. ( 26392659 )
2015
42
Balanitis is a risk factor for herpes zoster. ( 25596845 )
2015
43
Circinate balanitis as the presenting symptom of sexually-acquired reactive arthritis: a case report. ( 25918330 )
2015
44
Dermoscopy of Zoon's plasma cell balanitis. ( 26670716 )
2015
45
Candida albicans and Streptococcus pyogenes balanitis: diabetes or STI? ( 26232734 )
2015
46
Pseudoepitheliomatous keratotic and micaceous balanitis of Civatte. ( 24860747 )
2014
47
Dermoscopy in plasma cell balanitis: its usefulness in diagnosis and follow-up. ( 25176141 )
2014
48
Treatment of urethral strictures in balanitis xerotica obliterans (BXO) using circular buccal mucosal meatoplasy: experience of 15 cases. ( 24704927 )
2014
49
Successful use of dapsone for the management of circinate balanitis. ( 24635073 )
2014
50
Therapeutic Efficacy of Topical Calcineurin Inhibitors in Plasma Cell Balanitis: Case Series and Review of the Literature. ( 24434685 )
2014

Variations for Balanitis

Expression for Balanitis

Search GEO for disease gene expression data for Balanitis.

Pathways for Balanitis

GO Terms for Balanitis

Cellular components related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 8.92 SLC5A2 TGM1 TGM2 TGM3

Biological processes related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.32 TGM1 TGM3
2 cellular protein modification process GO:0006464 9.26 TGM1 TGM3
3 keratinocyte differentiation GO:0030216 9.16 TGM1 TGM3
4 cell envelope organization GO:0043163 8.96 TGM1 TGM3
5 peptide cross-linking GO:0018149 8.8 TGM1 TGM2 TGM3

Molecular functions related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring acyl groups GO:0016746 9.13 TGM1 TGM2 TGM3
2 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM1 TGM2 TGM3

Sources for Balanitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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