MCID: BLN010
MIFTS: 34

Balanitis

Categories: Reproductive diseases

Aliases & Classifications for Balanitis

Summaries for Balanitis

MalaCards based summary : Balanitis is related to balanitis xerotica obliterans and skin disease. An important gene associated with Balanitis is TGM2 (Transglutaminase 2). The drugs Empagliflozin and Sodium-Glucose Transporter 2 Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and kidney.

Wikipedia : 75 Balanitis is inflammation of the glans penis. When the foreskin is also affected, it is termed... more...

Related Diseases for Balanitis

Diseases related to Balanitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 balanitis xerotica obliterans 33.3 TGM3 TGM2 TGM1
2 skin disease 29.2 TGM3 TGM1
3 leukoplakia of penis 11.7
4 phimosis 11.6
5 lichen sclerosus 11.6
6 balanoposthitis 11.6
7 lichen sclerosus et atrophicus 11.6
8 peyronie's disease 11.2
9 hypospadias 10.6
10 urethral stricture 10.4
11 erythroplakia 10.4
12 verrucous carcinoma 10.3
13 vulvitis 10.3
14 syphilis 10.3
15 squamous cell carcinoma 10.3
16 in situ carcinoma 10.3
17 urethritis 10.2
18 primary syphilis 10.2
19 reactive arthritis 10.2
20 mucositis 10.2
21 penile cancer 10.2
22 candidiasis 10.2
23 keratosis 10.2
24 impotence 10.2
25 vulvovaginitis 10.2
26 paraphimosis 10.2
27 conjunctivitis 10.2
28 lichen planus 10.2
29 malignant tumor of penis 10.2
30 telangiectasis 10.1
31 penile disease 10.1
32 cystitis 10.1
33 papilloma 10.1
34 contact dermatitis 10.1
35 necrobiosis lipoidica 10.1
36 cellulitis 10.1
37 pustulosis of palm and sole 10.1
38 herpes simplex 10.1
39 psoriasis 10.1
40 lymphangitis 10.1
41 pustular psoriasis 10.1
42 fixed drug eruption 10.1
43 autoimmune disease 9.9
44 ige responsiveness, atopic 9.9
45 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
46 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
47 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
48 leprosy 3 9.9
49 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9
50 leukemia, acute lymphoblastic 9.9

Graphical network of the top 20 diseases related to Balanitis:



Diseases related to Balanitis

Symptoms & Phenotypes for Balanitis

Drugs & Therapeutics for Balanitis

Drugs for Balanitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Empagliflozin Approved Phase 4 864070-44-0
2 Sodium-Glucose Transporter 2 Inhibitors Phase 4
3 Hypoglycemic Agents Phase 4
4
Acetaminophen Approved Phase 1 103-90-2 1983
5
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
6
Ibuprofen Approved Phase 1 15687-27-1 3672
7
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
8
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
9 Anti-Infective Agents Phase 1
10 Anti-Inflammatory Agents Phase 1
11 Anesthetics, Local Phase 1
12 Analgesics Phase 1
13 Cyclooxygenase Inhibitors Phase 1
14 Analgesics, Non-Narcotic Phase 1
15 Anti-Inflammatory Agents, Non-Steroidal Phase 1
16 Peripheral Nervous System Agents Phase 1
17 Central Nervous System Depressants Phase 1
18 Ketorolac Tromethamine Phase 1
19 Anesthetics, General Phase 1
20 Antipyretics Phase 1
21 Platelet Aggregation Inhibitors Phase 1
22 Anesthetics, Inhalation Phase 1
23 Antirheumatic Agents Phase 1
24
Triamcinolone Approved, Vet_approved 124-94-7 31307
25
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
26 triamcinolone acetonide
27 Triamcinolone hexacetonide
28 Triamcinolone diacetate
29 glucocorticoids
30 Hormones
31 Retinol palmitate
32 Immunosuppressive Agents
33 Hormone Antagonists
34 retinol
35 Immunologic Factors
36 Hormones, Hormone Substitutes, and Hormone Antagonists
37 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation: A Randomised Double-blind Placebo-controlled Trial (The SEESAW Study) Recruiting NCT02798744 Phase 4 Empagliflozin;Placebo
2 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety and Acceptability of Carraguard™ (PC-515) Vaginal Gel Among Heterosexual Couples in Chiang Rai Completed NCT00213057 Phase 1 Carraguard (PC-515)
3 A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
4 A Bicentre Retrospective Study of Features and Outcomes of Patients With Reactive Arthritis Completed NCT03926429
5 Circumcision Versus Preputioplasty for BXO in Children: A Feasibility Randomised Controlled Trial Completed NCT02854995
6 A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of the Dominican Republic (DR) Completed NCT02337179
7 Evaluation of the ShangRing vs. Mogen Clamp for Early Infant Male Circumcision (EIMC) in Sub-Saharan Africa Recruiting NCT03338699

Search NIH Clinical Center for Balanitis

Cochrane evidence based reviews: balanitis

Genetic Tests for Balanitis

Anatomical Context for Balanitis

MalaCards organs/tissues related to Balanitis:

41
Skin, Testes, Kidney, Brain, Bone, Bone Marrow, Lymph Node

Publications for Balanitis

Articles related to Balanitis:

(show top 50) (show all 723)
# Title Authors PMID Year
1
A case-control study of risk factors associated with Zoon balanitis in men. 38
30903714 2019
2
A tale of an acute erosive balanitis. 38
31383382 2019
3
Penile Horn: A Rare Presentation of Pseudoepitheliomatous, Keratotic, and Micaceous Balanitis Successfully Treated with Oral Acitretin. 38
31334071 2019
4
Balanitis xerotica obliterans: a review of diagnosis and management. 38
30315576 2019
5
Pediatric lichen sclerosus: A systematic review of 4516 cases. 38
31260081 2019
6
Palate erosions in reactive arthritis. 38
31353842 2019
7
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. 38
30130825 2019
8
Topical mupirocin 2% ointment for diagnosis of Zoon's balanitis and monotherapy of balanitis circumscripta plasmacellularis. 38
30604433 2019
9
Pseudo circinate balanitis: great masquerader lives. 38
30808720 2019
10
Accuracy of dermoscopy in distinguishing erythroplasia of Queyrat from common forms of chronic balanitis: results from a multicentric observational study. 38
30468529 2019
11
Zoon Balanitis in an immune-competent teenager. 38
28895662 2019
12
Syphilitic balanitis of Follmann: two case reports. 38
30471083 2019
13
Re: Single-Stage Urethroplasty with Buccal Mucosal Inlay Graft for Stricture Caused by Balanitis Xerotica Obliterans in Boys: . 38
30759653 2019
14
Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012. 38
30426132 2019
15
Penile cancer epidemiology and risk factors: a contemporary review. 38
30562185 2019
16
Empagliflozin in posttransplantation diabetes mellitus: A prospective, interventional pilot study on glucose metabolism, fluid volume, and patient safety. 38
30585690 2019
17
Comparative risk of genital infections associated with sodium-glucose co-transporter-2 inhibitors. 38
30207042 2019
18
Surgical managements of pseudoepitheliomatous keratotic and micaceous balanitis: A case report. 38
30684817 2019
19
Balanitis circinata. 38
30071931 2018
20
Abnormal dartos fascia in buried penis and hypospadias: Evidence from histopathology. 38
30554609 2018
21
Prepuce sparing: Use of Z-plasty for treatment of phimosis and scarred foreskin. 38
29909192 2018
22
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. 38
29395150 2018
23
Zoon's plasma cell balanitis: clinical and dermoscopic features in pediatric patients. 38
30117600 2018
24
Circumcision is still the gold standard in management of plasma cell balanitis. 38
30246920 2018
25
Thalidomide in plasma cell balanitis refractory to conventional topical treatment. 38
30484535 2018
26
Handheld reflectance confocal microscopy, dermatoscopy and histopathological correlation of common inflammatory balanitis. 38
29457262 2018
27
[Correlation between the genotypes and clinical symptoms of human papilloma virus in male outpatients at STD clinics]. 38
30173432 2018
28
High variability within Candida albicans transcription factor RLM1: Isolates from vulvovaginal infections show a clear bias toward high molecular weight alleles. 38
29420774 2018
29
Balanitis in Acute Lymphoblastic Leukemia: A Rare Etiology and Unusual Presentation. 38
30127570 2018
30
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). 38
29974722 2018
31
Candida Balanitis with Hyperplastic Plaque Mimicking Vascular Neoplasm. 38
29722348 2018
32
Routine histopathological examination of the foreskin after circumcision for clinically suspected lichen sclerosus in children: Is it a waste of resources? 38
29405913 2018
33
Benefits of Urologic-Dermatologic Consultations for the Diagnosis of Cutaneous Penile Lesions: A Prospective Study. 38
29079166 2018
34
[Dermato-urology: Male genital lesions urologist should know]. 38
29428190 2018
35
Syphilitic balanitis of Follmann. 38
29564878 2018
36
Nonvenereal Penile Dermatoses: A Retrospective Study. 38
29644193 2018
37
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. 38
29534008 2018
38
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. 38
29150196 2018
39
[Safety of SGLT2 inhibitors. A review of the adverse drug reactions registered in a national database]. 38
29183654 2018
40
Balanitis associated with FOLFIRI chemotherapy. 38
29387750 2018
41
Simultaneous Occurrence of Balanoposthitis Circumscripta Plasmacellularis Zoon, Phimosis and in Situ Carcinoma of the Penis: Case Report with An Unusual Ulcerated Polypoid Variant of Zoon's Disease and a Carcinoma in Situ of Reserve Cell Type. 38
29483984 2018
42
Can lichen sclerosus be diagnosed by preputial appearance or symptoms? 38
30271758 2018
43
Surgical management of buried penis in adults. 38
30386659 2018
44
Characteristics of Idiopathic Urethral Strictures: A Link to Remote Perineal Trauma? 38
28755966 2017
45
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. 38
29234536 2017
46
Balanitis: A Unique Presentation of Diabetes in an Elderly Male. 38
29467066 2017
47
Image Gallery: Generalized circinate cutaneous lesions simulating circinate balanitis. 38
29192976 2017
48
Prevalence of rheumatic musculoskeletal symptoms in rural and urban areas : a cross-sectional study in northern India. 38
29077271 2017
49
[Clinical and immunohistochemical correlation of balanitis xerotica obliterans]. 38
29266891 2017
50
Clinical outcomes in a specialist male genital skin clinic: prospective follow-up of 600 patients. 38
28597554 2017

Variations for Balanitis

Expression for Balanitis

Search GEO for disease gene expression data for Balanitis.

Pathways for Balanitis

GO Terms for Balanitis

Cellular components related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 8.92 TGM3 TGM2 TGM1 SLC5A2

Biological processes related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.32 TGM3 TGM1
2 cellular protein modification process GO:0006464 9.26 TGM3 TGM1
3 keratinocyte differentiation GO:0030216 9.16 TGM3 TGM1
4 cell envelope organization GO:0043163 8.96 TGM3 TGM1
5 peptide cross-linking GO:0018149 8.8 TGM3 TGM2 TGM1

Molecular functions related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring acyl groups GO:0016746 9.13 TGM3 TGM2 TGM1
2 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM3 TGM2 TGM1

Sources for Balanitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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