MCID: BLN010
MIFTS: 37

Balanitis

Categories: Reproductive diseases

Aliases & Classifications for Balanitis

Summaries for Balanitis

MalaCards based summary : Balanitis is related to balanitis xerotica obliterans and balanoposthitis. An important gene associated with Balanitis is TGM2 (Transglutaminase 2), and among its related pathways/superpathways are NRF2 pathway and Hexose transport. The drugs Empagliflozin and Hypoglycemic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and testes, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Balanitis is inflammation of the glans penis. When the foreskin is also affected, it is termed... more...

Related Diseases for Balanitis

Diseases related to Balanitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 balanitis xerotica obliterans 33.7 TGM3 TGM2 TGM1 ECM1
2 balanoposthitis 31.0 SLC5A4 SLC5A2 SLC5A1 ILVBL DPP4
3 vulvitis 30.5 SLC5A4 SLC5A2 ILVBL
4 urethritis 30.4 MRAP CRP
5 penile disease 30.4 SLC5A4 SLC5A2
6 pustulosis of palm and sole 30.3 MRAP CRP
7 syphilis 29.9 MRAP CRP
8 hyperglycemia 29.1 SLC5A2 SLC5A1 DPP4
9 vulvovaginitis 29.1 SLC5A4 SLC5A2 SLC5A1 REG1A ILVBL
10 skin disease 28.4 TGM3 TGM1 ECM1 DPP4 CRP
11 acute cystitis 27.7 SLC5A4 SLC5A2 SLC5A1 REG1A DPP4 CRP
12 leukoplakia of penis 11.8
13 phimosis 11.6
14 lichen sclerosus et atrophicus 11.6
15 peyronie's disease 11.2
16 hypospadias 10.6
17 urethral stricture 10.4
18 spinocerebellar ataxia 35 10.4 TGM3 TGM2
19 erythroplakia 10.4
20 verrucous carcinoma 10.3
21 testicular sex cord-stromal neoplasm 10.3 SLC5A4 SLC5A2
22 testicular leydig cell tumor 10.3 SLC5A4 SLC5A2
23 squamous cell carcinoma 10.3
24 in situ carcinoma 10.3
25 fanconi-like syndrome 10.2 SLC5A2 SLC5A1
26 acute diarrhea 10.2 TGM3 SLC5A1
27 primary syphilis 10.2
28 reactive arthritis 10.2
29 pineal region meningioma 10.2 TGM3 CRP
30 dermatitis herpetiformis 10.2 TGM3 TGM2 TGM1
31 duodenitis 10.2 TGM2 CRP
32 mucositis 10.2
33 penile cancer 10.2
34 candidiasis 10.2
35 keratosis 10.2
36 impotence 10.2
37 paraphimosis 10.2
38 conjunctivitis 10.2
39 lichen planus 10.2
40 malignant tumor of penis 10.2
41 anterior scleritis 10.2 MRAP CRP
42 scleritis 10.2 MRAP CRP
43 olecranon bursitis 10.2 MRAP CRP
44 bursitis 10.2 MRAP CRP
45 posterior scleritis 10.2 MRAP CRP
46 orbital plasma cell granuloma 10.1 MRAP CRP
47 chronic orbital inflammation 10.1 MRAP CRP
48 neuroretinitis 10.1 MRAP CRP
49 epididymo-orchitis 10.1 MRAP CRP
50 discitis 10.1 MRAP CRP

Graphical network of the top 20 diseases related to Balanitis:



Diseases related to Balanitis

Symptoms & Phenotypes for Balanitis

MGI Mouse Phenotypes related to Balanitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 CRP DPP4 MRAP REG1A SLC5A1 SLC5A2

Drugs & Therapeutics for Balanitis

Drugs for Balanitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Empagliflozin Approved Phase 4 864070-44-0
2 Hypoglycemic Agents Phase 4
3 Sodium-Glucose Transporter 2 Inhibitors Phase 4
4
Ketorolac Approved Phase 1 66635-83-4, 74103-06-3 3826
5
Acetaminophen Approved Phase 1 103-90-2 1983
6
Ibuprofen Approved Phase 1 15687-27-1 3672
7
Sevoflurane Approved, Vet_approved Phase 1 28523-86-6 5206
8
Bupivacaine Approved, Investigational Phase 1 2180-92-9, 38396-39-3 2474
9 Anti-Infective Agents Phase 1
10 Anti-Inflammatory Agents Phase 1
11 Ketorolac Tromethamine Phase 1
12 Analgesics, Non-Narcotic Phase 1
13 Platelet Aggregation Inhibitors Phase 1
14 Anesthetics, General Phase 1
15 Analgesics Phase 1
16 Antipyretics Phase 1
17 Cyclooxygenase Inhibitors Phase 1
18 Anesthetics, Inhalation Phase 1
19 Anesthetics, Local Phase 1
20 Antirheumatic Agents Phase 1
21 Anti-Inflammatory Agents, Non-Steroidal Phase 1
22
Triamcinolone Approved, Vet_approved 124-94-7 31307
23
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
24 Hormone Antagonists
25 Hormones
26 glucocorticoids
27 Retinol palmitate
28 retinol
29 Triamcinolone diacetate
30 triamcinolone acetonide
31 Triamcinolone hexacetonide
32 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation: A Randomised Double-blind Placebo-controlled Trial (The SEESAW Study) Completed NCT02798744 Phase 4 Empagliflozin;Placebo
2 A Randomized, Placebo-controlled, Double-blind Trial to Assess Expanded Safety and Acceptability of Carraguard™ (PC-515) Vaginal Gel Among Heterosexual Couples in Chiang Rai Completed NCT00213057 Phase 1 Carraguard (PC-515)
3 A Pilot Study Evaluating Pain Outcomes of Ketorolac Administration in Children Undergoing Circumcision Completed NCT02973958 Phase 1 Bupivacaine;Sevoflurane;Acetaminophen;Ibuprofen;Ketorolac
4 A Bicentre Retrospective Study of Features and Outcomes of Patients With Reactive Arthritis Completed NCT03926429
5 Circumcision Versus Preputioplasty for BXO in Children: A Feasibility Randomised Controlled Trial Completed NCT02854995
6 A Pilot Study to Introduce Male Circumcision (MC) Services to Prevent HIV Infection in Two High Prevalence Areas of the Dominican Republic (DR) Completed NCT02337179
7 Evaluation of the ShangRing vs. Mogen Clamp for Early Infant Male Circumcision (EIMC) in Sub-Saharan Africa Recruiting NCT03338699

Search NIH Clinical Center for Balanitis

Cochrane evidence based reviews: balanitis

Genetic Tests for Balanitis

Anatomical Context for Balanitis

MalaCards organs/tissues related to Balanitis:

40
Skin, Kidney, Testes, Bone Marrow, Bone, Lymph Node, Brain

Publications for Balanitis

Articles related to Balanitis:

(show top 50) (show all 743)
# Title Authors PMID Year
1
Save the foreskin: Outcomes of preputioplasty in the treatment of childhood phimosis. 61
31548120 2020
2
Successful treatment of micaceous balanitis with 5% topical imiquimod: case report and review of the literature. 61
31846060 2020
3
Penile Calciphylaxis. 61
32194088 2020
4
Euphorbia urethritis: The minor scourge of the Garden Spurge. 61
32469623 2020
5
Balanitis Xerotica Obliterans Associated With Differentiated Penile Intraepithelial Neoplasia and "Bramble-Bush" Elastic Fibers Accumulation: A Finding Not Specific for Penicillamine Intake. 61
32472770 2020
6
Ultrasound evidence of bladder outlet obstruction secondary to lichen sclerosus et atrophicus in boys (balanitis xerotica obliterans). 61
31455543 2020
7
Primary Urethral Tuberculosis With Urethrocutaneous Fistula in Association With Balanitis Xerotica Obliterans. 61
32325139 2020
8
Treatment of balanitis xerotica obliterans in pediatric patients. 61
32250071 2020
9
Anogenital Dermatitis in Men Who Have Sex with Men. 61
32115132 2020
10
Zoon balanitis-does it exist? 61
31660645 2020
11
Zoon Balanitis: misdiagnosis or missed diagnosis? 61
31660642 2020
12
Is Non-Chlamydial Non-Gonococcal Urethritis Associated with Significant Clinical Complications in Men? A Systematic Review. 61
32398991 2020
13
A Rare Cause of a Scrotal Abscess due to the Symbiotic Infection of Gardnerella vaginalis and Prevotella bivia in an Adult Male. 61
32024139 2020
14
Tissue engineered indigenous pericardial patch urethroplasty: A promising solution to a nagging problem. 61
31970073 2020
15
Recent advances in understanding and managing Lichen Sclerosus. 61
32518626 2020
16
Balanitis xerotica obliterans: an update for clinicians. 61
31760506 2020
17
Pseudoepitheliomatous, Keratotic, and Micaceous Balanitis. 61
31921499 2020
18
Rituximab as most adequate treatment option for CD20-positive balanitis plasmacellularis Zoon! 61
31664744 2019
19
Persistent Mü̈llerian duct syndrome in a beluga whale Delphinapterus leucas. 61
31724560 2019
20
A case-control study of risk factors associated with Zoon balanitis in men. 61
30903714 2019
21
Balanitis xerotica obliterans: a review of diagnosis and management. 61
30315576 2019
22
Penile Horn: A Rare Presentation of Pseudoepitheliomatous, Keratotic, and Micaceous Balanitis Successfully Treated with Oral Acitretin. 61
31334071 2019
23
A tale of an acute erosive balanitis. 61
31383382 2019
24
In situ squamous cell carcinoma of male and female external genitalia. 61
31922109 2019
25
Topical mupirocin 2% ointment for diagnosis of Zoon's balanitis and monotherapy of balanitis circumscripta plasmacellularis. 61
30604433 2019
26
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. 61
30130825 2019
27
Accuracy of dermoscopy in distinguishing erythroplasia of Queyrat from common forms of chronic balanitis: results from a multicentric observational study. 61
30468529 2019
28
Pseudo circinate balanitis: great masquerader lives. 61
30808720 2019
29
Zoon Balanitis in an immune-competent teenager. 61
28895662 2019
30
Syphilitic balanitis of Follmann: two case reports. 61
30471083 2019
31
Re: Single-Stage Urethroplasty with Buccal Mucosal Inlay Graft for Stricture Caused by Balanitis Xerotica Obliterans in Boys: . 61
30759653 2019
32
Penile cancer epidemiology and risk factors: a contemporary review. 61
30562185 2019
33
Risk Factors for Penile Intraepithelial Neoplasia: A Population-based Register Study in Sweden, 2000-2012. 61
30426132 2019
34
Empagliflozin in posttransplantation diabetes mellitus: A prospective, interventional pilot study on glucose metabolism, fluid volume, and patient safety. 61
30585690 2019
35
Comparative risk of genital infections associated with sodium-glucose co-transporter-2 inhibitors. 61
30207042 2019
36
Urogenital infections in patients with diabetes mellitus: Beyond the conventional aspects. 61
32031031 2019
37
Surgical managements of pseudoepitheliomatous keratotic and micaceous balanitis: A case report. 61
30684817 2019
38
A Case of Squamous Cell Carcinoma of the Anterior Urethra in a Man. 61
31768143 2019
39
Prepuce sparing: Use of Z-plasty for treatment of phimosis and scarred foreskin. 61
29909192 2018
40
Balanitis circinata. 61
30071931 2018
41
Abnormal dartos fascia in buried penis and hypospadias: Evidence from histopathology. 61
30554609 2018
42
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. 61
29395150 2018
43
Zoon's plasma cell balanitis: clinical and dermoscopic features in pediatric patients. 61
30117600 2018
44
Circumcision is still the gold standard in management of plasma cell balanitis. 61
30246920 2018
45
Thalidomide in plasma cell balanitis refractory to conventional topical treatment. 61
30484535 2018
46
Handheld reflectance confocal microscopy, dermatoscopy and histopathological correlation of common inflammatory balanitis. 61
29457262 2018
47
[Correlation between the genotypes and clinical symptoms of human papilloma virus in male outpatients at STD clinics]. 61
30173432 2018
48
High variability within Candida albicans transcription factor RLM1: Isolates from vulvovaginal infections show a clear bias toward high molecular weight alleles. 61
29420774 2018
49
Balanitis in Acute Lymphoblastic Leukemia: A Rare Etiology and Unusual Presentation. 61
30127570 2018
50
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). 61
29974722 2018

Variations for Balanitis

Expression for Balanitis

Search GEO for disease gene expression data for Balanitis.

Pathways for Balanitis

Pathways related to Balanitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 SLC5A4 SLC5A2 SLC5A1
2
Show member pathways
10.8 SLC5A4 SLC5A2 SLC5A1

GO Terms for Balanitis

Cellular components related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.23 TGM3 TGM2 TGM1 SLC5A2 SLC5A1 REG1A

Biological processes related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium ion transport GO:0006814 9.54 SLC5A4 SLC5A2 SLC5A1
2 carbohydrate transport GO:0008643 9.43 SLC5A2 SLC5A1
3 sodium ion import across plasma membrane GO:0098719 9.4 SLC5A2 SLC5A1
4 glucose import across plasma membrane GO:0098708 9.32 SLC5A2 SLC5A1
5 cell envelope organization GO:0043163 9.26 TGM3 TGM1
6 alpha-glucoside transport GO:0000017 9.16 SLC5A2 SLC5A1
7 peptide cross-linking GO:0018149 9.13 TGM3 TGM2 TGM1
8 glucose transmembrane transport GO:1904659 8.8 SLC5A4 SLC5A2 SLC5A1

Molecular functions related to Balanitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 TGM2 REG1A MRAP DPP4 CRP
2 transmembrane transporter activity GO:0022857 9.54 SLC5A4 SLC5A2 SLC5A1
3 transferase activity, transferring acyl groups GO:0016746 9.5 TGM3 TGM2 TGM1
4 D-glucose transmembrane transporter activity GO:0055056 9.26 SLC5A2 SLC5A1
5 alpha-glucoside transmembrane transporter activity GO:0015151 9.16 SLC5A2 SLC5A1
6 protein-glutamine gamma-glutamyltransferase activity GO:0003810 9.13 TGM3 TGM2 TGM1
7 glucose:sodium symporter activity GO:0005412 8.8 SLC5A4 SLC5A2 SLC5A1

Sources for Balanitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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