MCID: BLN002
MIFTS: 44

Balanitis Xerotica Obliterans

Categories: Reproductive diseases

Aliases & Classifications for Balanitis Xerotica Obliterans

MalaCards integrated aliases for Balanitis Xerotica Obliterans:

Name: Balanitis Xerotica Obliterans 12 45 15 74
Penile Lichen Sclerosus 12
Penile Leukoplakia 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13477
ICD9CM 36 607.81
MeSH 45 D052798
NCIt 51 C3523
SNOMED-CT 69 43790000

Summaries for Balanitis Xerotica Obliterans

Disease Ontology : 12 A balantitis characterized by white plaques or patches on genitals.

MalaCards based summary : Balanitis Xerotica Obliterans, also known as penile lichen sclerosus, is related to lichen sclerosus and balanitis. An important gene associated with Balanitis Xerotica Obliterans is TGM2 (Transglutaminase 2), and among its related pathways/superpathways are Pathways in cancer and MicroRNAs in cancer. The drugs Triamcinolone and Vitamin A have been mentioned in the context of this disorder. Affiliated tissues include skin, cervix and t cells, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 77 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Related Diseases for Balanitis Xerotica Obliterans

Diseases related to Balanitis Xerotica Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 lichen sclerosus 33.2 ELN TP53
2 balanitis 32.4 TGM1 TGM2 TGM3
3 squamous cell carcinoma 30.6 CDKN2A PTGS2 TP53 VEGFA
4 verrucous carcinoma 30.2 CDKN2A TP53
5 leukoplakia of penis 12.1
6 lichen sclerosus et atrophicus 11.9
7 peyronie's disease 11.6
8 hypospadias 10.6
9 urethral stricture 10.6
10 phimosis 10.5
11 penile cancer, adult 10.5
12 elastosis perforans serpiginosa 10.4 ELN TGM1
13 telangiectasis 10.3
14 adenosquamous carcinoma 10.3
15 duplication of urethra 10.3
16 wrinkles 10.3 ELN VEGFA
17 infiltrating angiolipoma 10.3 CDKN2A VEGFA
18 autoimmune disease of skin and connective tissue 10.3 TGM2 TGM3
19 bowenoid papulosis 10.2 CDKN2A PTGS2
20 bladder squamous cell carcinoma 10.2 CDKN2A TP53
21 keratinizing squamous cell carcinoma 10.2 CDKN2A TP53
22 spitz nevus 10.2 CDKN2A TP53
23 radiation proctitis 10.2 PECAM1 VEGFA
24 bladder carcinoma in situ 10.2 CDKN2A TP53
25 capillary hemangioma 10.2 PECAM1 VEGFA
26 vulva squamous cell carcinoma 10.2 CDKN2A TP53
27 scrotal carcinoma 10.2 CDKN2A TP53
28 thyroid lymphoma 10.2 CDKN2A TP53
29 vulvar disease 10.2 CDKN2A TP53
30 optic disk drusen 10.2 ELN VEGFA
31 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
32 bartholin's gland disease 10.2 CDKN2A TP53
33 anal squamous cell carcinoma 10.2 CDKN2A TP53
34 megaesophagus 10.2 CDKN2A TP53
35 hydrocele 10.2 PECAM1 VEGFA
36 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
37 gastric adenosquamous carcinoma 10.2 CDKN2A TP53
38 anogenital venereal wart 10.2 CDKN2A TP53
39 cervix uteri carcinoma in situ 10.2 CDKN2A TP53
40 uterus carcinoma in situ 10.2 CDKN2A TP53
41 oral leukoplakia 10.2 CDKN2A TP53
42 protoplasmic astrocytoma 10.1 PTGS2 TP53
43 meningeal melanomatosis 10.1 CDKN2A TP53
44 suppressor of tumorigenicity 3 10.1 CDKN2A TP53
45 recurrent respiratory papillomatosis 10.1 PTGS2 TP53
46 neutrophil migration 10.1
47 pityriasis rubra pilaris 10.1
48 dedifferentiated liposarcoma 10.1 CDKN2A TP53
49 endocervical adenocarcinoma 10.1 CDKN2A TP53
50 soft tissue sarcoma 10.1 TP53 VEGFA

Graphical network of the top 20 diseases related to Balanitis Xerotica Obliterans:



Diseases related to Balanitis Xerotica Obliterans

Symptoms & Phenotypes for Balanitis Xerotica Obliterans

MGI Mouse Phenotypes related to Balanitis Xerotica Obliterans:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.19 AKTIP CDKN2A MYRF PTGS2 TGM1 TGM2
2 homeostasis/metabolism MP:0005376 10.16 CDKN2A H2AFX MCM3 PECAM1 PTGS2 TGM1
3 growth/size/body region MP:0005378 10.15 AKTIP CDKN2A H2AFX MCM3 PTGS2 TGM1
4 cellular MP:0005384 10.13 CDKN2A H2AFX MCM3 PECAM1 PTGS2 TGM2
5 hematopoietic system MP:0005397 10.08 CDKN2A H2AFX MCM3 PECAM1 PTGS2 TGM2
6 mortality/aging MP:0010768 10.07 CDKN2A H2AFX MCM3 MYRF PTGS2 TGM1
7 endocrine/exocrine gland MP:0005379 10.05 CDKN2A H2AFX MCM3 PTGS2 TGM2 TP53
8 integument MP:0010771 9.98 CDKN2A MCM3 PTGS2 TGM1 TGM3 TP53
9 liver/biliary system MP:0005370 9.88 CDKN2A MCM3 PECAM1 PTGS2 TP53 VEGFA
10 neoplasm MP:0002006 9.87 CDKN2A H2AFX MCM3 PTGS2 TGM2 TP53
11 renal/urinary system MP:0005367 9.73 PECAM1 PTGS2 TGM2 TGM3 TP53 VEGFA
12 respiratory system MP:0005388 9.63 CDKN2A PECAM1 PTGS2 TGM3 TP53 VEGFA
13 skeleton MP:0005390 9.5 AKTIP CDKN2A PECAM1 PTGS2 TGM3 TP53
14 vision/eye MP:0005391 9.1 CDKN2A H2AFX MYRF PTGS2 TP53 VEGFA

Drugs & Therapeutics for Balanitis Xerotica Obliterans

Drugs for Balanitis Xerotica Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
2
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
3 Hormone Antagonists Not Applicable
4 Triamcinolone hexacetonide Not Applicable
5 Immunosuppressive Agents Not Applicable
6 Anti-Inflammatory Agents Not Applicable
7 Immunologic Factors Not Applicable
8 glucocorticoids Not Applicable
9 retinol Not Applicable
10 Retinol palmitate Not Applicable
11 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
12 Hormones Not Applicable
13 Triamcinolone diacetate Not Applicable
14 triamcinolone acetonide Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable

Search NIH Clinical Center for Balanitis Xerotica Obliterans

Cochrane evidence based reviews: balanitis xerotica obliterans

Genetic Tests for Balanitis Xerotica Obliterans

Anatomical Context for Balanitis Xerotica Obliterans

MalaCards organs/tissues related to Balanitis Xerotica Obliterans:

42
Skin, Cervix, T Cells, Lung, Colon, Bone, Pancreas

Publications for Balanitis Xerotica Obliterans

Articles related to Balanitis Xerotica Obliterans:

(show top 50) (show all 123)
# Title Authors Year
1
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. ( 30130825 )
2019
2
Re: Single-Stage Urethroplasty with Buccal Mucosal Inlay Graft for Stricture Caused by Balanitis Xerotica Obliterans in Boys: . ( 30759653 )
2019
3
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. ( 29150196 )
2018
4
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
5
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. ( 29534008 )
2018
6
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). ( 29974722 )
2018
7
Balanitis xerotica obliterans: a review of diagnosis and management. ( 30315576 )
2018
8
Penile Lichen Sclerosus Treated with 1927 nm Thulium Fiber Laser and Photodynamic Therapy: A New Possible Therapeutic Approach. ( 29298401 )
2018
9
Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years' duration: A case report. ( 30214805 )
2018
10
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). ( 28043767 )
2017
11
Recurrence after management of meatal balanitis xerotica obliterans. ( 28089110 )
2017
12
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. ( 28089293 )
2017
13
Balanitis xerotica obliterans: has its diagnostic accuracy improved with time? ( 28620502 )
2017
14
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
15
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. ( 29234536 )
2017
16
Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life. ( 28161837 )
2017
17
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. ( 27649154 )
2016
18
Penile lichen sclerosus: An urologist's nightmare! - A single center experience. ( 26229314 )
2015
19
Penile lichen sclerosus: An enigmatic and challenging disease. ( 26229315 )
2015
20
Balanitis xerotica obliterans in children and adolescents: a literature review and clinical series. ( 24295833 )
2014
21
Treatment of urethral strictures in balanitis xerotica obliterans (BXO) using circular buccal mucosal meatoplasy: experience of 15 cases. ( 24704927 )
2014
22
Meatal stenosis in boys following circumcision for lichen sclerosus (balanitis xerotica obliterans). ( 24992332 )
2014
23
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. ( 23296396 )
2013
24
Intralesional adalimumab for the treatment of refractory balanitis xerotica obliterans. ( 23324752 )
2013
25
Genital lichen sclerosus/balanitis xerotica obliterans in men with penile carcinoma: a critical analysis. ( 23356463 )
2013
26
Foreskin preputioplasty and intralesional triamcinolone: a valid alternative to circumcision for balanitis xerotica obliterans. ( 22498393 )
2012
27
Management of boys with abnormal appearance of meatus at circumcision for balanitis xerotica obliterans. ( 22613322 )
2012
28
Paediatric balanitis xerotica obliterans: an 8-year experience. ( 22649954 )
2012
29
Balanitis xerotica obliterans in children and its incidence under the age of 5 years. ( 21705275 )
2012
30
Skin phototype and local trauma in the onset of balanitis xerotica obliterans (BXO) in circumcised patients. ( 22210729 )
2012
31
The surgical treatment of Balanitis Xerotica Obliterans. ( 21713168 )
2011
32
Management of boys with abnormal appearance of meatus at circumcision for balanitis xerotica obliterans. ( 21929920 )
2011
33
Penile lichen sclerosus (balanitis xerotica obliterans). ( 22085120 )
2011
34
Implantation dermoid and balanitis xerotica obliterans: rare complications after hypospadias repair: case gallery and review of relevant literature. ( 19360553 )
2010
35
Extensive balanitis xerotica obliterans of urethrocutaneous fistula presenting as mass in scrotum. ( 19913886 )
2010
36
Case of a congenital urethral duplication being unmasked following circumcision for balanitis xerotica obliterans. ( 20529516 )
2010
37
Long standing balanitis xerotica obliterans resulting in renal impairment in a child. ( 18587589 )
2008
38
Urethral reconstruction in balanitis xerotica obliterans. ( 18931544 )
2008
39
Human papillomavirus-associated increase in p16INK4A expression in penile lichen sclerosus and squamous cell carcinoma. ( 18047520 )
2008
40
Penile lichen sclerosus after allogeneic stem cell transplantation. ( 18503592 )
2008
41
Malignant transformation of penile lichen sclerosus: exactly how common is it? ( 19126024 )
2008
42
Penile carcinoma arising in balanitis xerotica obliterans. ( 16464280 )
2006
43
The response of clinical balanitis xerotica obliterans to the application of topical steroid-based creams. ( 16516649 )
2006
44
Is the association between balanitis xerotica obliterans and penile carcinoma underestimated? ( 16831147 )
2006
45
Extensive balanitis xerotica obliterans (BXO) involving the anterior urethra and scrotum. ( 17180441 )
2006
46
Detailed analysis of the T-cell lymphocytic infiltrate in penile lichen sclerosus: an immunohistochemical and molecular investigation. ( 16681690 )
2006
47
Association of penile lichen sclerosus and oncogenic human papillomavirus infection. ( 16796627 )
2006
48
Penile lichen sclerosus: Correlation between histopathologic features and risk of cancer. ( 17311737 )
2006
49
Buccal mucosal urethroplasty for balanitis xerotica obliterans related urethral strictures: the outcome of 1 and 2-stage techniques. ( 15643208 )
2005
50
The response of clinical balanitis xerotica obliterans to the application of topical steroid-based creams. ( 15852285 )
2005

Variations for Balanitis Xerotica Obliterans

Expression for Balanitis Xerotica Obliterans

Search GEO for disease gene expression data for Balanitis Xerotica Obliterans.

Pathways for Balanitis Xerotica Obliterans

GO Terms for Balanitis Xerotica Obliterans

Biological processes related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.56 CDKN2A PTGS2 TGM2 TP53
2 cellular response to hypoxia GO:0071456 9.5 PTGS2 TP53 VEGFA
3 cellular response to gamma radiation GO:0071480 9.4 H2AFX TP53
4 cellular senescence GO:0090398 9.37 CDKN2A H2AFX
5 replicative senescence GO:0090399 9.16 CDKN2A TP53
6 peptide cross-linking GO:0018149 9.13 TGM1 TGM2 TGM3
7 cell envelope organization GO:0043163 8.62 TGM1 TGM3

Molecular functions related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.16 ELN VEGFA
2 transferase activity, transferring acyl groups GO:0016746 9.13 TGM1 TGM2 TGM3
3 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM1 TGM2 TGM3

Sources for Balanitis Xerotica Obliterans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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