MCID: BLN002
MIFTS: 40

Balanitis Xerotica Obliterans

Categories: Reproductive diseases

Aliases & Classifications for Balanitis Xerotica Obliterans

MalaCards integrated aliases for Balanitis Xerotica Obliterans:

Name: Balanitis Xerotica Obliterans 12 44 15 73
Penile Lichen Sclerosus 12
Penile Leukoplakia 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13477
ICD9CM 35 607.81
MeSH 44 D052798
NCIt 50 C3523
SNOMED-CT 68 43790000

Summaries for Balanitis Xerotica Obliterans

Disease Ontology : 12 A balantitis characterized by white plaques or patches on genitals.

MalaCards based summary : Balanitis Xerotica Obliterans, also known as penile lichen sclerosus, is related to balanitis and leukoplakia of penis. An important gene associated with Balanitis Xerotica Obliterans is TGM2 (Transglutaminase 2), and among its related pathways/superpathways are Hepatitis C and Hepatocellular Carcinoma and Aryl Hydrocarbon Receptor. The drugs Triamcinolone and Vitamin A have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Related Diseases for Balanitis Xerotica Obliterans

Diseases related to Balanitis Xerotica Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 balanitis 32.1 TGM1 TGM2 TGM3
2 leukoplakia of penis 12.0
3 lichen sclerosus 11.9
4 lichen sclerosus et atrophicus 11.9
5 peyronie's disease 11.5
6 hypospadias 10.6
7 squamous cell carcinoma 10.6
8 urethral stricture 10.6
9 phimosis 10.5
10 penile cancer, adult 10.5
11 telangiectasis 10.3
12 adenosquamous carcinoma 10.3
13 autoimmune disease of skin and connective tissue 10.2 TGM2 TGM3
14 dermatitis herpetiformis 10.2 TGM2 TGM3
15 infiltrating angiolipoma 10.1 CDKN2A VEGFA
16 verrucous carcinoma 10.1
17 geographic tongue 10.1 AKTIP VEGFA
18 bowenoid papulosis 10.1 CDKN2A PTGS2
19 cervical adenosquamous carcinoma 10.1 CDKN2A PTGS2
20 optic nerve neoplasm 10.1 CDKN2A H2AFX
21 nasopharyngeal disease 10.1 CDKN2A VEGFA
22 barrett's adenocarcinoma 10.0 CDKN2A PTGS2
23 hydrops, lactic acidosis, and sideroblastic anemia 10.0 PTGS2 VEGFA
24 pharynx cancer 10.0 CDKN2A VEGFA
25 esophageal disease 10.0 CDKN2A PTGS2
26 actinic keratosis 10.0 CDKN2A PTGS2
27 pancreatic ductal carcinoma 10.0 CDKN2A TGM2 VEGFA
28 extratemporal epilepsy 10.0 MYRF TGM2
29 cervix disease 10.0 CDKN2A VEGFA
30 adenomyosis 10.0 PTGS2 VEGFA
31 supratentorial cancer 10.0 CDKN2A VEGFA
32 cerebrum cancer 9.9 CDKN2A VEGFA
33 reproductive system disease 9.9 CDKN2A PTGS2 VEGFA
34 gastrointestinal system cancer 9.9 CDKN2A PTGS2 VEGFA
35 gastrointestinal system disease 9.9 CDKN2A PTGS2 VEGFA
36 pancreas adenocarcinoma 9.9 CDKN2A PTGS2 VEGFA
37 adenocarcinoma 9.9 CDKN2A PTGS2 VEGFA
38 adamantinoma of long bones 9.9 CDKN2A PTGS2 VEGFA
39 squamous cell carcinoma, head and neck 9.9 CDKN2A PTGS2 VEGFA
40 cervical adenocarcinoma 9.8 CDKN2A PTGS2
41 esophageal cancer 9.8 CDKN2A PTGS2 TGM3 VEGFA
42 large intestine cancer 9.4 CDKN2A H2AFX MYRF PTGS2 VEGFA

Graphical network of the top 20 diseases related to Balanitis Xerotica Obliterans:



Diseases related to Balanitis Xerotica Obliterans

Symptoms & Phenotypes for Balanitis Xerotica Obliterans

MGI Mouse Phenotypes related to Balanitis Xerotica Obliterans:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 AKTIP APLN CDKN2A MYRF PTGS2 TGM1
2 growth/size/body region MP:0005378 10.06 AKTIP APLN CDKN2A H2AFX MCM3 PTGS2
3 homeostasis/metabolism MP:0005376 10.02 APLN CDKN2A H2AFX MCM3 PTGS2 TGM1
4 endocrine/exocrine gland MP:0005379 9.91 CDKN2A H2AFX MCM3 PTGS2 TGM2 VEGFA
5 mortality/aging MP:0010768 9.91 CDKN2A H2AFX MCM3 MYRF PTGS2 TGM1
6 integument MP:0010771 9.8 CDKN2A MCM3 PTGS2 TGM1 TGM3 VEGFA
7 neoplasm MP:0002006 9.63 CDKN2A H2AFX MCM3 PTGS2 TGM2 VEGFA
8 no phenotypic analysis MP:0003012 9.35 APLN CDKN2A PTGS2 TGM2 VEGFA
9 vision/eye MP:0005391 9.17 AKTIP APLN CDKN2A H2AFX MYRF PTGS2

Drugs & Therapeutics for Balanitis Xerotica Obliterans

Drugs for Balanitis Xerotica Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
2
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
3 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
4 Triamcinolone diacetate Not Applicable
5 Immunosuppressive Agents Not Applicable
6 Hormone Antagonists Not Applicable
7 Retinol palmitate Not Applicable
8 triamcinolone acetonide Not Applicable
9 retinol Not Applicable
10 Immunologic Factors Not Applicable
11 Anti-Inflammatory Agents Not Applicable
12 Hormones Not Applicable
13 glucocorticoids Not Applicable
14 Triamcinolone hexacetonide Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable

Search NIH Clinical Center for Balanitis Xerotica Obliterans

Cochrane evidence based reviews: balanitis xerotica obliterans

Genetic Tests for Balanitis Xerotica Obliterans

Anatomical Context for Balanitis Xerotica Obliterans

MalaCards organs/tissues related to Balanitis Xerotica Obliterans:

41
Skin, Lung, Bone, Colon, Tongue, Pancreas, Cervix

Publications for Balanitis Xerotica Obliterans

Articles related to Balanitis Xerotica Obliterans:

(show top 50) (show all 110)
# Title Authors Year
1
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
2
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. ( 29534008 )
2018
3
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). ( 29974722 )
2018
4
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. ( 30130825 )
2018
5
Balanitis xerotica obliterans: a review of diagnosis and management. ( 30315576 )
2018
6
Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years' duration: A case report. ( 30214805 )
2018
7
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. ( 29234536 )
2017
8
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. ( 29150196 )
2017
9
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
10
Balanitis xerotica obliterans: has its diagnostic accuracy improved with time? ( 28620502 )
2017
11
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. ( 27649154 )
2016
12
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. ( 28089293 )
2016
13
Recurrence after management of meatal balanitis xerotica obliterans. ( 28089110 )
2016
14
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). ( 28043767 )
2016
15
Penile lichen sclerosus: An urologist's nightmare! - A single center experience. ( 26229314 )
2015
16
Penile lichen sclerosus: An enigmatic and challenging disease. ( 26229315 )
2015
17
Treatment of urethral strictures in balanitis xerotica obliterans (BXO) using circular buccal mucosal meatoplasy: experience of 15 cases. ( 24704927 )
2014
18
Meatal Stenosis in Boys following Circumcision for Lichen Sclerosus (Balanitis Xerotica Obliterans). ( 24992332 )
2014
19
Balanitis xerotica obliterans in children and adolescents: A literature review and clinical series. ( 24295833 )
2013
20
Intralesional adalimumab for the treatment of refractory balanitis xerotica obliterans. ( 23324752 )
2013
21
Genital lichen sclerosus/balanitis xerotica obliterans in men with penile carcinoma: a critical analysis. ( 23356463 )
2013
22
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. ( 23296396 )
2013
23
Foreskin preputioplasty and intralesional triamcinolone: a valid alternative to circumcision for balanitis xerotica obliterans. ( 22498393 )
2012
24
Paediatric balanitis xerotica obliterans: an 8-year experience. ( 22649954 )
2012
25
Balanitis xerotica obliterans in children and its incidence under the age of 5 years. ( 21705275 )
2012
26
Skin phototype and local trauma in the onset of balanitis xerotica obliterans (BXO) in circumcised patients. ( 22210729 )
2012
27
Management of boys with abnormal appearance of meatus at circumcision for balanitis xerotica obliterans. ( 22613322 )
2012
28
Management of boys with abnormal appearance of meatus at circumcision for balanitis xerotica obliterans. ( 21929920 )
2011
29
The surgical treatment of Balanitis Xerotica Obliterans. ( 21713168 )
2011
30
Penile lichen sclerosus (balanitis xerotica obliterans). ( 22085120 )
2011
31
Case of a congenital urethral duplication being unmasked following circumcision for balanitis xerotica obliterans. ( 20529516 )
2010
32
Extensive balanitis xerotica obliterans of urethrocutaneous fistula presenting as mass in scrotum. ( 19913886 )
2010
33
Implantation dermoid and balanitis xerotica obliterans: rare complications after hypospadias repair: case gallery and review of relevant literature. ( 19360553 )
2010
34
Long standing balanitis xerotica obliterans resulting in renal impairment in a child. ( 18587589 )
2008
35
Urethral reconstruction in balanitis xerotica obliterans. ( 18931544 )
2008
36
The response of clinical balanitis xerotica obliterans to the application of topical steroid-based creams. ( 16516649 )
2006
37
Extensive balanitis xerotica obliterans (BXO) involving the anterior urethra and scrotum. ( 17180441 )
2006
38
Is the association between balanitis xerotica obliterans and penile carcinoma underestimated? ( 16831147 )
2006
39
Penile carcinoma arising in balanitis xerotica obliterans. ( 16464280 )
2006
40
Buccal mucosal urethroplasty for balanitis xerotica obliterans related urethral strictures: the outcome of 1 and 2-stage techniques. ( 15643208 )
2005
41
The response of clinical balanitis xerotica obliterans to the application of topical steroid-based creams. ( 15852285 )
2005
42
Heroic measures may not always be justified in extensive urethral stricture due to lichen sclerosus (balanitis xerotica obliterans). ( 15879815 )
2005
43
Balanitis xerotica obliterans in boys. ( 16145451 )
2005
44
High incidence of balanitis xerotica obliterans in boys with phimosis: prospective 10-year study. ( 16060864 )
2005
45
Heroic measures may not always be justified in extensive urethral stricture due to lichen sclerosus (balanitis xerotica obliterans). ( 15351594 )
2004
46
Balanitis xerotica obliterans: epidemiologic distribution in an equal access health care system. ( 12602705 )
2003
47
Balanitis xerotica obliterans: a form of lichen sclerosus. ( 12602704 )
2003
48
Treatment of balanitis xerotica obliterans with topical tacrolimus. ( 12913735 )
2003
49
Urethral stone presenting as a stop valve--a rare complication of balanitis xerotica obliterans. ( 12092665 )
2001
50
The response of balanitis xerotica obliterans to local steroid application compared with placebo in children. ( 11125410 )
2001

Variations for Balanitis Xerotica Obliterans

Expression for Balanitis Xerotica Obliterans

Search GEO for disease gene expression data for Balanitis Xerotica Obliterans.

Pathways for Balanitis Xerotica Obliterans

Pathways related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 PTGS2 VEGFA
2 10.64 PTGS2 VEGFA
3 10.19 PTGS2 VEGFA

GO Terms for Balanitis Xerotica Obliterans

Biological processes related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.5 APLN PTGS2 VEGFA
2 positive regulation of cell adhesion GO:0045785 9.4 TGM2 VEGFA
3 lactation GO:0007595 9.37 APLN VEGFA
4 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.26 PTGS2 VEGFA
5 cellular senescence GO:0090398 9.16 CDKN2A H2AFX
6 peptide cross-linking GO:0018149 9.13 TGM1 TGM2 TGM3
7 cell envelope organization GO:0043163 8.62 TGM1 TGM3

Molecular functions related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring acyl groups GO:0016746 9.13 TGM1 TGM2 TGM3
2 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM1 TGM2 TGM3

Sources for Balanitis Xerotica Obliterans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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