MCID: BLN002
MIFTS: 41

Balanitis Xerotica Obliterans

Categories: Reproductive diseases

Aliases & Classifications for Balanitis Xerotica Obliterans

MalaCards integrated aliases for Balanitis Xerotica Obliterans:

Name: Balanitis Xerotica Obliterans 12 45 15 74
Penile Lichen Sclerosus 12
Penile Leukoplakia 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13477
ICD9CM 36 607.81
MeSH 45 D052798
NCIt 51 C3523
SNOMED-CT 69 43790000

Summaries for Balanitis Xerotica Obliterans

Disease Ontology : 12 A balantitis characterized by white plaques or patches on genitals.

MalaCards based summary : Balanitis Xerotica Obliterans, also known as penile lichen sclerosus, is related to lichen sclerosus and balanitis. An important gene associated with Balanitis Xerotica Obliterans is TGM2 (Transglutaminase 2), and among its related pathways/superpathways are Pathways in cancer and MicroRNAs in cancer. The drugs Triamcinolone and Vitamin A have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 77 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Related Diseases for Balanitis Xerotica Obliterans

Diseases related to Balanitis Xerotica Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 lichen sclerosus 33.2 ELN TP53
2 balanitis 32.4 TGM1 TGM2 TGM3
3 squamous cell carcinoma 30.6 CDKN2A PTGS2 TP53 VEGFA
4 verrucous carcinoma 30.2 CDKN2A TP53
5 leukoplakia of penis 12.1
6 lichen sclerosus et atrophicus 11.9
7 peyronie's disease 11.6
8 hypospadias 10.6
9 urethral stricture 10.6
10 phimosis 10.5
11 penile cancer, adult 10.5
12 elastosis perforans serpiginosa 10.4 ELN TGM1
13 telangiectasis 10.3
14 adenosquamous carcinoma 10.3
15 wrinkles 10.3 ELN VEGFA
16 infiltrating angiolipoma 10.3 CDKN2A VEGFA
17 autoimmune disease of skin and connective tissue 10.3 TGM2 TGM3
18 bowenoid papulosis 10.2 CDKN2A PTGS2
19 bladder squamous cell carcinoma 10.2 CDKN2A TP53
20 keratinizing squamous cell carcinoma 10.2 CDKN2A TP53
21 spitz nevus 10.2 CDKN2A TP53
22 radiation proctitis 10.2 PECAM1 VEGFA
23 bladder carcinoma in situ 10.2 CDKN2A TP53
24 capillary hemangioma 10.2 PECAM1 VEGFA
25 vulva squamous cell carcinoma 10.2 CDKN2A TP53
26 scrotal carcinoma 10.2 CDKN2A TP53
27 thyroid lymphoma 10.2 CDKN2A TP53
28 vulvar disease 10.2 CDKN2A TP53
29 optic disk drusen 10.2 ELN VEGFA
30 nasal cavity adenocarcinoma 10.2 CDKN2A TP53
31 bartholin's gland disease 10.2 CDKN2A TP53
32 anal squamous cell carcinoma 10.2 CDKN2A TP53
33 megaesophagus 10.2 CDKN2A TP53
34 hydrocele 10.2 PECAM1 VEGFA
35 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A TP53
36 gastric adenosquamous carcinoma 10.2 CDKN2A TP53
37 anogenital venereal wart 10.2 CDKN2A TP53
38 cervix uteri carcinoma in situ 10.2 CDKN2A TP53
39 uterus carcinoma in situ 10.2 CDKN2A TP53
40 oral leukoplakia 10.2 CDKN2A TP53
41 protoplasmic astrocytoma 10.1 PTGS2 TP53
42 meningeal melanomatosis 10.1 CDKN2A TP53
43 suppressor of tumorigenicity 3 10.1 CDKN2A TP53
44 recurrent respiratory papillomatosis 10.1 PTGS2 TP53
45 extratemporal epilepsy 10.1 MYRF TGM2
46 dedifferentiated liposarcoma 10.1 CDKN2A TP53
47 endocervical adenocarcinoma 10.1 CDKN2A TP53
48 soft tissue sarcoma 10.1 TP53 VEGFA
49 gastric lymphoma 10.1 TP53 VEGFA
50 penile disease 10.1 CDKN2A TP53

Graphical network of the top 20 diseases related to Balanitis Xerotica Obliterans:



Diseases related to Balanitis Xerotica Obliterans

Symptoms & Phenotypes for Balanitis Xerotica Obliterans

MGI Mouse Phenotypes related to Balanitis Xerotica Obliterans:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.19 AKTIP CDKN2A MYRF PTGS2 TGM1 TGM2
2 homeostasis/metabolism MP:0005376 10.16 CDKN2A H2AFX MCM3 PECAM1 PTGS2 TGM1
3 growth/size/body region MP:0005378 10.15 AKTIP CDKN2A H2AFX MCM3 PTGS2 TGM1
4 cellular MP:0005384 10.13 CDKN2A H2AFX MCM3 PECAM1 PTGS2 TGM2
5 hematopoietic system MP:0005397 10.08 CDKN2A H2AFX MCM3 PECAM1 PTGS2 TGM2
6 mortality/aging MP:0010768 10.07 CDKN2A H2AFX MCM3 MYRF PTGS2 TGM1
7 endocrine/exocrine gland MP:0005379 10.05 CDKN2A H2AFX MCM3 PTGS2 TGM2 TP53
8 integument MP:0010771 9.98 CDKN2A MCM3 PTGS2 TGM1 TGM3 TP53
9 liver/biliary system MP:0005370 9.88 CDKN2A MCM3 PECAM1 PTGS2 TP53 VEGFA
10 neoplasm MP:0002006 9.87 CDKN2A H2AFX MCM3 PTGS2 TGM2 TP53
11 renal/urinary system MP:0005367 9.73 PECAM1 PTGS2 TGM2 TGM3 TP53 VEGFA
12 respiratory system MP:0005388 9.63 CDKN2A PECAM1 PTGS2 TGM3 TP53 VEGFA
13 skeleton MP:0005390 9.5 AKTIP CDKN2A PECAM1 PTGS2 TGM3 TP53
14 vision/eye MP:0005391 9.1 CDKN2A H2AFX MYRF PTGS2 TP53 VEGFA

Drugs & Therapeutics for Balanitis Xerotica Obliterans

Drugs for Balanitis Xerotica Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
2
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
3 Triamcinolone hexacetonide Not Applicable
4 Anti-Inflammatory Agents Not Applicable
5 Retinol palmitate Not Applicable
6 Hormones Not Applicable
7 retinol Not Applicable
8 Immunosuppressive Agents Not Applicable
9 Hormone Antagonists Not Applicable
10 Immunologic Factors Not Applicable
11 Triamcinolone diacetate Not Applicable
12 triamcinolone acetonide Not Applicable
13 glucocorticoids Not Applicable
14 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Circumcision Versus Preputioplasty for BXO in Children Completed NCT02854995 Not Applicable

Search NIH Clinical Center for Balanitis Xerotica Obliterans

Cochrane evidence based reviews: balanitis xerotica obliterans

Genetic Tests for Balanitis Xerotica Obliterans

Anatomical Context for Balanitis Xerotica Obliterans

MalaCards organs/tissues related to Balanitis Xerotica Obliterans:

42
Skin

Publications for Balanitis Xerotica Obliterans

Articles related to Balanitis Xerotica Obliterans:

(show top 50) (show all 111)
# Title Authors Year
1
Re: Single-Stage Urethroplasty with Buccal Mucosal Inlay Graft for Stricture Caused by Balanitis Xerotica Obliterans in Boys: . ( 30759653 )
2019
2
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. ( 29395150 )
2018
3
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. ( 29534008 )
2018
4
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). ( 29974722 )
2018
5
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. ( 30130825 )
2018
6
Balanitis xerotica obliterans: a review of diagnosis and management. ( 30315576 )
2018
7
Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years' duration: A case report. ( 30214805 )
2018
8
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. ( 29234536 )
2017
9
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. ( 29150196 )
2017
10
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. ( 28892974 )
2017
11
Balanitis xerotica obliterans: has its diagnostic accuracy improved with time? ( 28620502 )
2017
12
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. ( 27649154 )
2016
13
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. ( 28089293 )
2016
14
Recurrence after management of meatal balanitis xerotica obliterans. ( 28089110 )
2016
15
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). ( 28043767 )
2016
16
Penile lichen sclerosus: An urologist's nightmare! - A single center experience. ( 26229314 )
2015
17
Penile lichen sclerosus: An enigmatic and challenging disease. ( 26229315 )
2015
18
Treatment of urethral strictures in balanitis xerotica obliterans (BXO) using circular buccal mucosal meatoplasy: experience of 15 cases. ( 24704927 )
2014
19
Meatal Stenosis in Boys following Circumcision for Lichen Sclerosus (Balanitis Xerotica Obliterans). ( 24992332 )
2014
20
Balanitis xerotica obliterans in children and adolescents: A literature review and clinical series. ( 24295833 )
2013
21
Intralesional adalimumab for the treatment of refractory balanitis xerotica obliterans. ( 23324752 )
2013
22
Genital lichen sclerosus/balanitis xerotica obliterans in men with penile carcinoma: a critical analysis. ( 23356463 )
2013
23
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. ( 23296396 )
2013
24
Foreskin preputioplasty and intralesional triamcinolone: a valid alternative to circumcision for balanitis xerotica obliterans. ( 22498393 )
2012
25
Paediatric balanitis xerotica obliterans: an 8-year experience. ( 22649954 )
2012
26
Balanitis xerotica obliterans in children and its incidence under the age of 5 years. ( 21705275 )
2012
27
Skin phototype and local trauma in the onset of balanitis xerotica obliterans (BXO) in circumcised patients. ( 22210729 )
2012
28
Management of boys with abnormal appearance of meatus at circumcision for balanitis xerotica obliterans. ( 22613322 )
2012
29
Management of boys with abnormal appearance of meatus at circumcision for balanitis xerotica obliterans. ( 21929920 )
2011
30
The surgical treatment of Balanitis Xerotica Obliterans. ( 21713168 )
2011
31
Penile lichen sclerosus (balanitis xerotica obliterans). ( 22085120 )
2011
32
Case of a congenital urethral duplication being unmasked following circumcision for balanitis xerotica obliterans. ( 20529516 )
2010
33
Extensive balanitis xerotica obliterans of urethrocutaneous fistula presenting as mass in scrotum. ( 19913886 )
2010
34
Implantation dermoid and balanitis xerotica obliterans: rare complications after hypospadias repair: case gallery and review of relevant literature. ( 19360553 )
2010
35
Long standing balanitis xerotica obliterans resulting in renal impairment in a child. ( 18587589 )
2008
36
Urethral reconstruction in balanitis xerotica obliterans. ( 18931544 )
2008
37
The response of clinical balanitis xerotica obliterans to the application of topical steroid-based creams. ( 16516649 )
2006
38
Extensive balanitis xerotica obliterans (BXO) involving the anterior urethra and scrotum. ( 17180441 )
2006
39
Is the association between balanitis xerotica obliterans and penile carcinoma underestimated? ( 16831147 )
2006
40
Penile carcinoma arising in balanitis xerotica obliterans. ( 16464280 )
2006
41
Buccal mucosal urethroplasty for balanitis xerotica obliterans related urethral strictures: the outcome of 1 and 2-stage techniques. ( 15643208 )
2005
42
The response of clinical balanitis xerotica obliterans to the application of topical steroid-based creams. ( 15852285 )
2005
43
Heroic measures may not always be justified in extensive urethral stricture due to lichen sclerosus (balanitis xerotica obliterans). ( 15879815 )
2005
44
Balanitis xerotica obliterans in boys. ( 16145451 )
2005
45
High incidence of balanitis xerotica obliterans in boys with phimosis: prospective 10-year study. ( 16060864 )
2005
46
Heroic measures may not always be justified in extensive urethral stricture due to lichen sclerosus (balanitis xerotica obliterans). ( 15351594 )
2004
47
Balanitis xerotica obliterans: epidemiologic distribution in an equal access health care system. ( 12602705 )
2003
48
Balanitis xerotica obliterans: a form of lichen sclerosus. ( 12602704 )
2003
49
Treatment of balanitis xerotica obliterans with topical tacrolimus. ( 12913735 )
2003
50
Urethral stone presenting as a stop valve--a rare complication of balanitis xerotica obliterans. ( 12092665 )
2001

Variations for Balanitis Xerotica Obliterans

Expression for Balanitis Xerotica Obliterans

Search GEO for disease gene expression data for Balanitis Xerotica Obliterans.

Pathways for Balanitis Xerotica Obliterans

GO Terms for Balanitis Xerotica Obliterans

Biological processes related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.56 CDKN2A PTGS2 TGM2 TP53
2 cellular response to hypoxia GO:0071456 9.5 PTGS2 TP53 VEGFA
3 cellular response to gamma radiation GO:0071480 9.4 H2AFX TP53
4 cellular senescence GO:0090398 9.37 CDKN2A H2AFX
5 replicative senescence GO:0090399 9.16 CDKN2A TP53
6 peptide cross-linking GO:0018149 9.13 TGM1 TGM2 TGM3
7 cell envelope organization GO:0043163 8.62 TGM1 TGM3

Molecular functions related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.16 ELN VEGFA
2 transferase activity, transferring acyl groups GO:0016746 9.13 TGM1 TGM2 TGM3
3 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM1 TGM2 TGM3

Sources for Balanitis Xerotica Obliterans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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