MCID: BLN002
MIFTS: 30

Balanitis Xerotica Obliterans

Categories: Reproductive diseases

Aliases & Classifications for Balanitis Xerotica Obliterans

MalaCards integrated aliases for Balanitis Xerotica Obliterans:

Name: Balanitis Xerotica Obliterans 12 43 15 71
Penile Lichen Sclerosus 12
Penile Leukoplakia 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13477
ICD9CM 34 607.81
MeSH 43 D052798
NCIt 49 C3523
SNOMED-CT 67 43790000
UMLS 71 C0022782 C0152460

Summaries for Balanitis Xerotica Obliterans

Disease Ontology : 12 A balantitis characterized by white plaques or patches on genitals.

MalaCards based summary : Balanitis Xerotica Obliterans, also known as penile lichen sclerosus, is related to lichen sclerosus et atrophicus and phimosis. An important gene associated with Balanitis Xerotica Obliterans is TGM2 (Transglutaminase 2), and among its related pathways/superpathways are Ca, cAMP and Lipid Signaling and Cell adhesion_Cell-matrix glycoconjugates. The drugs Triamcinolone and Vitamin A have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells.

Wikipedia : 74 Lichen sclerosus (LS) is a chronic, inflammatory skin disease of unknown cause, commonly appearing as... more...

Related Diseases for Balanitis Xerotica Obliterans

Diseases related to Balanitis Xerotica Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 lichen sclerosus et atrophicus 32.9 ELN ECM1
2 phimosis 31.2 ELN ECM1
3 balanitis 31.2 TGM3 TGM2 TGM1 ECM1
4 urethral stricture 30.6 MCU BOLL
5 skin disease 29.0 TGM3 TGM1 ELN ECM1
6 leukoplakia of penis 12.2
7 peyronie's disease 11.7
8 hypospadias 10.8
9 squamous cell carcinoma 10.7
10 penile cancer 10.6
11 impotence 10.6
12 malignant tumor of penis 10.6
13 in situ carcinoma 10.5
14 autoimmune disease 10.4
15 vitiligo-associated multiple autoimmune disease susceptibility 6 10.4
16 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
17 vitiligo-associated multiple autoimmune disease susceptibility 1 10.4
18 sexual disorder 10.4
19 telangiectasis 10.4
20 balanoposthitis 10.4
21 penile disease 10.4
22 cystitis 10.4
23 adenosquamous carcinoma 10.4
24 urinary tract obstruction 10.4
25 duplication of urethra 10.4
26 verrucous carcinoma 10.3
27 retinoblastoma 10.1
28 scleroderma, familial progressive 10.1
29 graft-versus-host disease 10.1
30 familial retinoblastoma 10.1
31 rapidly involuting congenital hemangioma 10.1
32 elastosis perforans serpiginosa 9.9 TGM1 ELN
33 papillary squamous carcinoma 9.9 TGM3 ELN
34 autoimmune disease of skin and connective tissue 9.9 TGM3 TGM2
35 dermatitis herpetiformis 9.8 TGM3 TGM2 TGM1
36 netherton syndrome 9.6 TGM3 TGM1
37 prolapse of urethra 9.6 MCU ELN
38 ichthyosis 9.5 TGM3 TGM2 TGM1
39 urethral syndrome 9.2 MCU ECM1 BOLL

Graphical network of the top 20 diseases related to Balanitis Xerotica Obliterans:



Diseases related to Balanitis Xerotica Obliterans

Symptoms & Phenotypes for Balanitis Xerotica Obliterans

Drugs & Therapeutics for Balanitis Xerotica Obliterans

Drugs for Balanitis Xerotica Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved 124-94-7 31307
2
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
3 Immunologic Factors
4 retinol
5 Retinol palmitate
6 Hormone Antagonists
7 Anti-Inflammatory Agents
8 Triamcinolone diacetate
9 Triamcinolone hexacetonide
10 triamcinolone acetonide
11 glucocorticoids
12 Hormones
13 Immunosuppressive Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Circumcision Versus Preputioplasty for BXO in Children: A Feasibility Randomised Controlled Trial Completed NCT02854995

Search NIH Clinical Center for Balanitis Xerotica Obliterans

Cochrane evidence based reviews: balanitis xerotica obliterans

Genetic Tests for Balanitis Xerotica Obliterans

Anatomical Context for Balanitis Xerotica Obliterans

MalaCards organs/tissues related to Balanitis Xerotica Obliterans:

40
Skin, T Cells

Publications for Balanitis Xerotica Obliterans

Articles related to Balanitis Xerotica Obliterans:

(show top 50) (show all 229)
# Title Authors PMID Year
1
Topographical Evaluation of Penile Lichen Sclerosus Reveals a Lymphocytic Depleted Variant, Preferentially Associated With Neoplasia: A Report of 200 Cases. 61
31969038 2020
2
Balanitis xerotica obliterans: an update for clinicians. 61
31760506 2020
3
Tissue engineered indigenous pericardial patch urethroplasty: A promising solution to a nagging problem. 61
31970073 2020
4
Save the foreskin: Outcomes of preputioplasty in the treatment of childhood phimosis. 61
31548120 2019
5
Ultrasound evidence of bladder outlet obstruction secondary to lichen sclerosus et atrophicus in boys (balanitis xerotica obliterans). 61
31455543 2019
6
Balanitis xerotica obliterans: a review of diagnosis and management. 61
30315576 2019
7
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. 61
30130825 2019
8
Re: Single-Stage Urethroplasty with Buccal Mucosal Inlay Graft for Stricture Caused by Balanitis Xerotica Obliterans in Boys: . 61
30759653 2019
9
Abnormal dartos fascia in buried penis and hypospadias: Evidence from histopathology. 61
30554609 2018
10
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. 61
29395150 2018
11
Penile Lichen Sclerosus Treated with 1927 nm Thulium Fiber Laser and Photodynamic Therapy: A New Possible Therapeutic Approach. 61
29298401 2018
12
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). 61
29974722 2018
13
Routine histopathological examination of the foreskin after circumcision for clinically suspected lichen sclerosus in children: Is it a waste of resources? 61
29405913 2018
14
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. 61
29534008 2018
15
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. 61
29150196 2018
16
Surgical management of buried penis in adults. 61
30386659 2018
17
Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years' duration: A case report. 61
30214805 2018
18
Can lichen sclerosus be diagnosed by preputial appearance or symptoms? 61
30271758 2018
19
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. 61
29234536 2017
20
Characteristics of Idiopathic Urethral Strictures: A Link to Remote Perineal Trauma? 61
28755966 2017
21
[Clinical and immunohistochemical correlation of balanitis xerotica obliterans]. 61
29266891 2017
22
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. 61
28892974 2017
23
Balanitis xerotica obliterans: has its diagnostic accuracy improved with time? 61
28620502 2017
24
Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life. 61
28161837 2017
25
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. 61
28089293 2017
26
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). 61
28043767 2017
27
Recurrence after management of meatal balanitis xerotica obliterans. 61
28089110 2017
28
Two-stage hypospadias repair with a free graft for severe primary and revision hypospadias: A single surgeon's experience with long-term follow-up. 61
27746246 2017
29
The Association Between BXO and Obesity in Boys Undergoing Circumcision. 61
29204461 2017
30
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. 61
27649154 2016
31
Penile Circular Fasciocutaneous (McAninch) Flap as an Option for Complex Anterior Urethral Stricture in Case of Non-Viable Buccal Mucosal Graft. 61
27630900 2016
32
Foreskin Morbidity in Uncircumcised Males. 61
27244821 2016
33
Management of Vesicoureteral Reflux by Endoscopic Injection of Dextranomer/Hyaluronic Acid in Adults. 61
27162514 2016
34
Benign penile skin anomalies in children: a primer for pediatricians. 61
25754752 2015
35
Penile lichen sclerosus: An urologist's nightmare! - A single center experience. 61
26229314 2015
36
Penile lichen sclerosus: An enigmatic and challenging disease. 61
26229315 2015
37
[Balanitis xerotica obliterans, underdiagnosed pathology of clinical relevance]. 61
27775307 2015
38
Steroid instillation for idiopathic urethritis in children: an 8-year experience. 61
24683102 2015
39
L1 gene sequence of a putative novel type human papillomavirus in an immunocompetent patient with glans lichen sclerosus. 61
25742152 2015
40
Meatal stenosis in boys following circumcision for lichen sclerosus (balanitis xerotica obliterans). 61
24992332 2014
41
[Current diagnosis and treatment of male genital lichen sclerosus]. 61
25095613 2014
42
Isolated preputial reconstruction in distal hypospadias. 61
24314817 2014
43
Treatment of urethral strictures in balanitis xerotica obliterans (BXO) using circular buccal mucosal meatoplasy: experience of 15 cases. 61
24704927 2014
44
SIU/ICUD Consultation on Urethral Strictures: Anterior urethra-lichen sclerosus. 61
24268357 2014
45
Balanitis xerotica obliterans in children and adolescents: a literature review and clinical series. 61
24295833 2014
46
Protein markers of malignant potential in penile and vulvar lichen sclerosus. 61
23399649 2013
47
[Balanitis xerotica obliterans with phimosis in elderly patients presenting with difficulty in urination]. 61
23827865 2013
48
Genital lichen sclerosus/balanitis xerotica obliterans in men with penile carcinoma: a critical analysis. 61
23356463 2013
49
Histopathological examination of the prepuce after circumcision: Is it a waste of resources? 61
23860069 2013
50
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. 61
23296396 2013

Variations for Balanitis Xerotica Obliterans

Expression for Balanitis Xerotica Obliterans

Search GEO for disease gene expression data for Balanitis Xerotica Obliterans.

Pathways for Balanitis Xerotica Obliterans

Pathways related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.06 TGM2 MCU
2 10.21 ELN ECM1

GO Terms for Balanitis Xerotica Obliterans

Cellular components related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 8.8 TGM2 ELN ECM1

Biological processes related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein modification process GO:0006464 9.32 TGM3 TGM1
2 keratinocyte differentiation GO:0030216 9.26 TGM3 TGM1
3 positive regulation of mitochondrial calcium ion concentration GO:0051561 9.16 TGM2 MCU
4 cell envelope organization GO:0043163 8.96 TGM3 TGM1
5 peptide cross-linking GO:0018149 8.8 TGM3 TGM2 TGM1

Molecular functions related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 9.16 ELN ECM1
2 transferase activity, transferring acyl groups GO:0016746 9.13 TGM3 TGM2 TGM1
3 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM3 TGM2 TGM1

Sources for Balanitis Xerotica Obliterans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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