MCID: BLN002
MIFTS: 38

Balanitis Xerotica Obliterans

Categories: Reproductive diseases

Aliases & Classifications for Balanitis Xerotica Obliterans

MalaCards integrated aliases for Balanitis Xerotica Obliterans:

Name: Balanitis Xerotica Obliterans 12 44 15 72
Penile Lichen Sclerosus 12
Penile Leukoplakia 72

Classifications:



External Ids:

Disease Ontology 12 DOID:13477
ICD9CM 35 607.81
MeSH 44 D052798
NCIt 50 C3523
SNOMED-CT 68 43790000
UMLS 72 C0022782 C0152460

Summaries for Balanitis Xerotica Obliterans

Disease Ontology : 12 A balantitis characterized by white plaques or patches on genitals.

MalaCards based summary : Balanitis Xerotica Obliterans, also known as penile lichen sclerosus, is related to lichen sclerosus and balanitis. An important gene associated with Balanitis Xerotica Obliterans is TGM2 (Transglutaminase 2), and among its related pathways/superpathways are Pathways in cancer and Mitotic G1-G1/S phases. The drugs Triamcinolone and Vitamin A have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related phenotypes are behavior/neurological and cellular

Wikipedia : 75 Lichen sclerosus (LS) is a skin disease of unknown cause, commonly appearing as whitish patches on the... more...

Related Diseases for Balanitis Xerotica Obliterans

Diseases related to Balanitis Xerotica Obliterans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 lichen sclerosus 33.6 TP53 ELN
2 balanitis 32.8 TGM3 TGM2 TGM1
3 penile disease 30.8 TP53 CDKN2A
4 verrucous carcinoma 30.5 TP53 CDKN2A
5 squamous cell carcinoma 30.4 VEGFA TP53 PTGS2 CDKN2A
6 leukoplakia of penis 12.2
7 lichen sclerosus et atrophicus 12.1
8 peyronie's disease 11.7
9 phimosis 11.0
10 urethral stricture 10.9
11 hypospadias 10.8
12 elastosis perforans serpiginosa 10.6 TGM1 ELN
13 penile cancer 10.6
14 impotence 10.6
15 malignant tumor of penis 10.6
16 in situ carcinoma 10.5
17 infiltrating angiolipoma 10.5 VEGFA CDKN2A
18 autoimmune disease of skin and connective tissue 10.5 TGM3 TGM2
19 bowenoid papulosis 10.4 PTGS2 CDKN2A
20 autoimmune disease 10.4
21 vitiligo-associated multiple autoimmune disease susceptibility 6 10.4
22 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
23 vitiligo-associated multiple autoimmune disease susceptibility 1 10.4
24 telangiectasis 10.4
25 balanoposthitis 10.4
26 cystitis 10.4
27 adenosquamous carcinoma 10.4
28 urinary tract obstruction 10.4
29 duplication of urethra 10.4
30 optic disk drusen 10.4 VEGFA ELN
31 radiation proctitis 10.3 VEGFA PECAM1
32 bladder squamous cell carcinoma 10.3 TP53 CDKN2A
33 keratinizing squamous cell carcinoma 10.3 TP53 CDKN2A
34 spitz nevus 10.3 TP53 CDKN2A
35 bladder carcinoma in situ 10.3 TP53 CDKN2A
36 scrotal carcinoma 10.3 TP53 CDKN2A
37 capillary hemangioma 10.3 VEGFA PECAM1
38 vulva squamous cell carcinoma 10.3 TP53 CDKN2A
39 bartholin's gland disease 10.3 TP53 CDKN2A
40 nasal cavity adenocarcinoma 10.3 TP53 CDKN2A
41 vulvar disease 10.3 TP53 CDKN2A
42 thyroid lymphoma 10.3 TP53 CDKN2A
43 anal squamous cell carcinoma 10.3 TP53 CDKN2A
44 gastric adenosquamous carcinoma 10.3 TP53 CDKN2A
45 glycogen-rich clear cell breast carcinoma 10.3 TP53 CDKN2A
46 hydrocele 10.3 VEGFA PECAM1
47 megaesophagus 10.3 TP53 CDKN2A
48 oral leukoplakia 10.3 TP53 CDKN2A
49 uterus carcinoma in situ 10.3 TP53 CDKN2A
50 cervix uteri carcinoma in situ 10.3 TP53 CDKN2A

Graphical network of the top 20 diseases related to Balanitis Xerotica Obliterans:



Diseases related to Balanitis Xerotica Obliterans

Symptoms & Phenotypes for Balanitis Xerotica Obliterans

MGI Mouse Phenotypes related to Balanitis Xerotica Obliterans:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 AKTIP CDKN2A PTGS2 TGM1 TGM2 TGM3
2 cellular MP:0005384 10.11 CDKN2A LIN9 MCM3 PECAM1 PTGS2 TGM2
3 growth/size/body region MP:0005378 10.11 AKTIP CDKN2A LIN9 MCM3 PTGS2 TGM1
4 homeostasis/metabolism MP:0005376 10.09 CDKN2A MCM3 PECAM1 PTGS2 TGM1 TGM2
5 endocrine/exocrine gland MP:0005379 10.02 CDKN2A LIN9 MCM3 PTGS2 TGM2 TP53
6 digestive/alimentary MP:0005381 9.97 CDKN2A LIN9 PECAM1 PTGS2 TP53 VEGFA
7 integument MP:0010771 9.95 CDKN2A MCM3 PTGS2 TGM1 TGM3 TP53
8 liver/biliary system MP:0005370 9.85 CDKN2A MCM3 PECAM1 PTGS2 TP53 VEGFA
9 neoplasm MP:0002006 9.8 CDKN2A MCM3 PTGS2 TGM2 TP53 VEGFA
10 no phenotypic analysis MP:0003012 9.73 CDKN2A LIN9 PTGS2 TGM2 TP53 VEGFA
11 renal/urinary system MP:0005367 9.63 PECAM1 PTGS2 TGM2 TGM3 TP53 VEGFA
12 respiratory system MP:0005388 9.43 CDKN2A PECAM1 PTGS2 TGM3 TP53 VEGFA
13 skeleton MP:0005390 9.17 AKTIP CDKN2A PECAM1 PTGS2 TGM3 TP53

Drugs & Therapeutics for Balanitis Xerotica Obliterans

Drugs for Balanitis Xerotica Obliterans (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved 124-94-7 31307
2
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
3 Anti-Inflammatory Agents
4 triamcinolone acetonide
5 Triamcinolone hexacetonide
6 Triamcinolone diacetate
7 glucocorticoids
8 Hormones
9 Retinol palmitate
10 Immunosuppressive Agents
11 Hormone Antagonists
12 retinol
13 Immunologic Factors
14 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Circumcision Versus Preputioplasty for BXO in Children: A Feasibility Randomised Controlled Trial Completed NCT02854995

Search NIH Clinical Center for Balanitis Xerotica Obliterans

Cochrane evidence based reviews: balanitis xerotica obliterans

Genetic Tests for Balanitis Xerotica Obliterans

Anatomical Context for Balanitis Xerotica Obliterans

MalaCards organs/tissues related to Balanitis Xerotica Obliterans:

41
Skin, T Cells

Publications for Balanitis Xerotica Obliterans

Articles related to Balanitis Xerotica Obliterans:

(show top 50) (show all 225)
# Title Authors PMID Year
1
Balanitis xerotica obliterans: a review of diagnosis and management. 38
30315576 2019
2
Pediatric lichen sclerosus: A systematic review of 4516 cases. 38
31260081 2019
3
10 Years' Experience in Balanitis Xerotica Obliterans: A Single-Institution Study. 38
30130825 2019
4
Re: Single-Stage Urethroplasty with Buccal Mucosal Inlay Graft for Stricture Caused by Balanitis Xerotica Obliterans in Boys: . 38
30759653 2019
5
Abnormal dartos fascia in buried penis and hypospadias: Evidence from histopathology. 38
30554609 2018
6
Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. 38
29395150 2018
7
Utility of uroflowmetry during the follow-up of children affected by balanitis xerotica obliterans (BXO). 38
29974722 2018
8
Penile Lichen Sclerosus Treated with 1927 nm Thulium Fiber Laser and Photodynamic Therapy: A New Possible Therapeutic Approach. 38
29298401 2018
9
Routine histopathological examination of the foreskin after circumcision for clinically suspected lichen sclerosus in children: Is it a waste of resources? 38
29405913 2018
10
Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. 38
29534008 2018
11
Single-stage urethroplasty with buccal mucosal inlay graft for stricture caused by balanitis xerotica obliterans in boys: Outcomes in the medium term. 38
29150196 2018
12
Surgical management of buried penis in adults. 38
30386659 2018
13
Treatment of penile lichen sclerosus with topical corticosteroids for over 25 years' duration: A case report. 38
30214805 2018
14
Can lichen sclerosus be diagnosed by preputial appearance or symptoms? 38
30271758 2018
15
Role of urethral plate and fossa navicularis biopsies in the detection of balanitis xerotica obliterans in boys undergoing redo hypospadias repair. 38
29234536 2017
16
Characteristics of Idiopathic Urethral Strictures: A Link to Remote Perineal Trauma? 38
28755966 2017
17
[Clinical and immunohistochemical correlation of balanitis xerotica obliterans]. 38
29266891 2017
18
Squamous Cell Carcinoma Penis in a Case of Urethral Stricture Due to Lichen Sclerosus Balanitis Xerotica Obliterans: A Case Report and Review of Literature. 38
28892974 2017
19
Balanitis xerotica obliterans: has its diagnostic accuracy improved with time? 38
28620502 2017
20
Recurrence after management of meatal balanitis xerotica obliterans. 38
28089110 2017
21
Bleeding after circumcision is more likely in children with lichen sclerosus (balanitis xerotica obliterans). 38
28043767 2017
22
Response to commentary to 'Bleeding after circumcision is more likely in children with Lichen Sclerosus (Balanitis Xerotica Obliterans)'. 38
28089293 2017
23
Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life. 38
28161837 2017
24
Two-stage hypospadias repair with a free graft for severe primary and revision hypospadias: A single surgeon's experience with long-term follow-up. 38
27746246 2017
25
The Association Between BXO and Obesity in Boys Undergoing Circumcision. 38
29204461 2017
26
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. 38
27649154 2016
27
Penile Circular Fasciocutaneous (McAninch) Flap as an Option for Complex Anterior Urethral Stricture in Case of Non-Viable Buccal Mucosal Graft. 38
27630900 2016
28
Foreskin Morbidity in Uncircumcised Males. 38
27244821 2016
29
Management of Vesicoureteral Reflux by Endoscopic Injection of Dextranomer/Hyaluronic Acid in Adults. 38
27162514 2016
30
Benign penile skin anomalies in children: a primer for pediatricians. 38
25754752 2015
31
Penile lichen sclerosus: An urologist's nightmare! - A single center experience. 38
26229314 2015
32
Penile lichen sclerosus: An enigmatic and challenging disease. 38
26229315 2015
33
[Balanitis xerotica obliterans, underdiagnosed pathology of clinical relevance]. 38
27775307 2015
34
Steroid instillation for idiopathic urethritis in children: an 8-year experience. 38
24683102 2015
35
L1 gene sequence of a putative novel type human papillomavirus in an immunocompetent patient with glans lichen sclerosus. 38
25742152 2015
36
Meatal stenosis in boys following circumcision for lichen sclerosus (balanitis xerotica obliterans). 38
24992332 2014
37
[Current diagnosis and treatment of male genital lichen sclerosus]. 38
25095613 2014
38
Isolated preputial reconstruction in distal hypospadias. 38
24314817 2014
39
Treatment of urethral strictures in balanitis xerotica obliterans (BXO) using circular buccal mucosal meatoplasy: experience of 15 cases. 38
24704927 2014
40
SIU/ICUD Consultation on Urethral Strictures: Anterior urethra-lichen sclerosus. 38
24268357 2014
41
Balanitis xerotica obliterans in children and adolescents: a literature review and clinical series. 38
24295833 2014
42
Protein markers of malignant potential in penile and vulvar lichen sclerosus. 38
23399649 2013
43
[Balanitis xerotica obliterans with phimosis in elderly patients presenting with difficulty in urination]. 38
23827865 2013
44
Genital lichen sclerosus/balanitis xerotica obliterans in men with penile carcinoma: a critical analysis. 38
23356463 2013
45
Histopathological examination of the prepuce after circumcision: Is it a waste of resources? 38
23860069 2013
46
Intralesional adalimumab for the treatment of refractory balanitis xerotica obliterans. 38
23324752 2013
47
Incidence of balanitis xerotica obliterans in boys younger than 10 years presenting with phimosis. 38
23296396 2013
48
Therapeutic strategies for patients with micropenis or penile dysmorphic disorder. 38
22890302 2012
49
Balanitis xerotica obliterans in children and its incidence under the age of 5 years. 38
21705275 2012
50
Management of boys with abnormal appearance of meatus at circumcision for balanitis xerotica obliterans. 38
22613322 2012

Variations for Balanitis Xerotica Obliterans

Expression for Balanitis Xerotica Obliterans

Search GEO for disease gene expression data for Balanitis Xerotica Obliterans.

Pathways for Balanitis Xerotica Obliterans

GO Terms for Balanitis Xerotica Obliterans

Biological processes related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.56 TP53 TGM2 PTGS2 CDKN2A
2 cellular response to hypoxia GO:0071456 9.5 VEGFA TP53 PTGS2
3 replicative senescence GO:0090399 9.16 TP53 CDKN2A
4 peptide cross-linking GO:0018149 9.13 TGM3 TGM2 TGM1
5 cell envelope organization GO:0043163 8.62 TGM3 TGM1

Molecular functions related to Balanitis Xerotica Obliterans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.16 VEGFA ELN
2 transferase activity, transferring acyl groups GO:0016746 9.13 TGM3 TGM2 TGM1
3 protein-glutamine gamma-glutamyltransferase activity GO:0003810 8.8 TGM3 TGM2 TGM1

Sources for Balanitis Xerotica Obliterans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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