Balo Concentric Sclerosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BLC015 MIFTS: 37	Balo Concentric Sclerosis Categories: Immune diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Balo Concentric Sclerosis

MalaCards integrated aliases for Balo Concentric Sclerosis:

Name: Balo Concentric Sclerosis ¹² ⁵⁸ ¹⁵

Balo's Concentric Sclerosis ¹² ⁷³ ²⁰ ⁷⁰

Diffuse Cerebral Sclerosis of Schilder ²⁰ ⁴⁴ ⁷⁰

Balo Disease ¹² ⁷³ ²⁰

Tumefactive Multiple Sclerosis ¹² ²⁰

Concentric Demyelination ²⁰ ⁵⁸

Encephalitis Periaxialis Concentrica ²⁰

Baló Concentric Sclerosis ²⁰

Marburg Variant ²⁰

Balo's Disease ²⁰

Characteristics:

Orphanet epidemiological data:

⁵⁸

balo concentric sclerosis
Inheritance: Multigenic/multifactorial; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³² ³³

Diseases of the nervous system

Demyelinating diseases of the central nervous system

Other demyelinating diseases of central nervous system

Concentric sclerosis [Baló]

Diffuse sclerosis

Orphanet: ⁵⁸

Rare neurological diseases

External Ids:

Disease Ontology ¹² DOID:0060215

ICD9CM ³⁴ 341.1

MeSH ⁴⁴ D002549

NCIt ⁵⁰ C84670

SNOMED-CT ⁶⁷ 44875002

ICD10 ³² G37.0

ICD10 via Orphanet ³³ G37.5

UMLS via Orphanet ⁷¹ C0004712

Orphanet ⁵⁸ ORPHA228165

UMLS ⁷⁰ C0004712 C0007795

Sources

Summaries for Balo Concentric Sclerosis

GARD : ²⁰ Tumefactive multiple sclerosis is characterized by a tumor -like lesion larger than two centimeters and signs and symptoms similar to those of a brain tumor. It is a rare form of multiple sclerosis (MS). Symptoms of tumefactive MS often differ from other MS cases and may include, headaches, changes in thinking, confusion, speech problems, seizures, and weakness. The cause of tumefactive MS is not known. It often develops into the relapsing-remitting form of MS. In other cases there is only one occurrence of the condition. In still others the disease process remains less clear. While there is no cure for tumefactive MS, treatments such as corticosteroids are available to decrease disease activity.

MalaCards based summary : Balo Concentric Sclerosis, also known as balo's concentric sclerosis, is related to optic neuritis and neuritis. An important gene associated with Balo Concentric Sclerosis is NOTCH3 (Notch Receptor 3). The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related phenotypes are hematopoietic system and immune system

Disease Ontology : ¹² A multiple sclerosis that is characterized by concentric layers of demyelinated tissues, tumor-like lesions larger than two centimeters and symptoms similar to those of a brain tumor.

Wikipedia : ⁷³ Baló's concentric sclerosis is a disease in which the white matter of the brain appears damaged in... more...

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Related Diseases for Balo Concentric Sclerosis

Diseases related to Balo Concentric Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)

#	Related Disease	Score	Top Affiliating Genes
1	optic neuritis	30.4	MOG MBP AQP4
2	neuritis	30.4	MOG MBP AQP4
3	neurosarcoidosis	30.2	MOG AQP4
4	demyelinating disease	30.2	MOG MBP IFNB1 AQP4
5	relapsing-remitting multiple sclerosis	30.0	MOG MBP IFNB1 AQP4
6	neuromyelitis optica	29.9	MOG MBP AQP4
7	encephalitis	29.8	MOG IFNB1 AQP4
8	acute disseminated encephalomyelitis	29.8	MOG MBP IFNB1 AQP4
9	myelitis	29.8	MOG MBP IFNB1 AQP4
10	progressive multifocal leukoencephalopathy	29.8	MBP IFNB1
11	multiple sclerosis	29.6	NOTCH3 MOG MBP IFNB1 AQP4
12	internuclear ophthalmoplegia	29.6	MOG MBP IFNB1 AQP4
13	mitochondrial dna depletion syndrome 4a	11.7
14	myelinoclastic diffuse sclerosis	11.5
15	pelizaeus-merzbacher disease	11.4
16	adrenoleukodystrophy	11.4
17	marburg acute multiple sclerosis	11.3
18	glioma	10.4
19	glial tumor	10.4
20	cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	10.2
21	ischemia	10.2
22	dysphagia	10.2
23	vascular myelopathy	10.2	MOG AQP4
24	hemiplegia	10.2
25	hepatitis c	10.2
26	pulmonary tuberculosis	10.2
27	oligodendroglioma	10.2
28	cocaine abuse	10.2
29	pathologic nystagmus	10.2
30	optic papillitis	10.2	MOG AQP4
31	acute retrobulbar neuritis	10.1	MBP AQP4
32	allergic encephalomyelitis	10.1	MOG MBP
33	color agnosia	10.1	MBP AQP4
34	glioma susceptibility 1	10.1
35	malignant astrocytoma	10.1
36	high grade glioma	10.1
37	central nervous system lymphoma	10.1
38	oligoastrocytoma	10.1
39	primary central nervous system lymphoma	10.1
40	acute hemorrhagic leukoencephalitis	10.1	MBP AQP4
41	traumatic brain injury	10.1	MBP AQP4
42	brain injury	10.1	MBP AQP4
43	covid-19	10.1
44	chromosome 18q deletion syndrome	10.1	MBP GJC2
45	guillain-barre syndrome	10.0	MOG MBP
46	subacute sclerosing panencephalitis	10.0	MOG MBP
47	leukoencephalopathy, hereditary diffuse, with spheroids	10.0	NOTCH3 MBP
48	autoimmune optic neuritis	10.0	MOG MBP AQP4
49	syringomyelia, noncommunicating isolated	10.0
50	sudanophilic cerebral sclerosis	10.0

Comorbidity relations with Balo Concentric Sclerosis via Phenotypic Disease Network (PDN):

Acute Cystitis

Graphical network of the top 20 diseases related to Balo Concentric Sclerosis:

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Symptoms & Phenotypes for Balo Concentric Sclerosis

MGI Mouse Phenotypes related to Balo Concentric Sclerosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.8	AQP4 GJC2 GJC3 IFNB1 MBP MOG
2	immune system	MP:0005387	9.76	AQP4 GJB6 GJC2 GJC3 IFNB1 MBP
3	hearing/vestibular/ear	MP:0005377	9.72	AQP4 GJB6 GJC3 MBP NOTCH3
4	nervous system	MP:0003631	9.56	AQP4 GJB6 GJC2 GJC3 IFNB1 MBP
5	vision/eye	MP:0005391	9.1	AQP4 GJC2 GJC3 MBP MOG NOTCH3

Sources

Drugs & Therapeutics for Balo Concentric Sclerosis

Drugs for Balo Concentric Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Methylprednisolone

Approved, Vet_approved

Phase 3

83-43-2

6741

Synonyms:

(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6Α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione

.DELTA.1-6.alpha.-Methylhydrocortisone

11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

121673-01-6

1-Dehydro-6alpha-methylhydrocortisone

1-Dehydro-6a-methylhydrocortisone

1-dehydro-6α-methylhydrocortisone

1-Dehydro-6α-methylhydrocortisone

4-08-00-03498 (Beilstein Handbook Reference)

46436_FLUKA

46436_RIEDEL

570-35-4

6 Methylprednisolone

6.alpha.-Methylprednisolone

6923-42-8

6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione

6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methylprednisolone

6-alpha-Methylprednisolone

6a-Methyl-11b,17a,21-triol-1,4-pregnadiene-3,20-dione

6a-Methylprednisolone

6-Methylprednisolone

6α-methyl-11β,17α,21-triol-1,4-pregnadiene-3,20-dione

6Α-methyl-11β,17α,21-triol-1,4-pregnadiene-3,20-dione

6Α-methylprednisolone

83-43-2

AC1L1N7A

Artisone-wyeth

Artisone-Wyeth

Besonia

Bio-0658

BPBio1_000174

BRD-K35240538-001-03-1

BRN 2340300

BSPBio_000158

CHEBI:6888

CHEMBL650

CID6741

CPD000058330

D00407

D008775

DB00959

delta(1)-6alpha-Methylhydrocortisone

Delta(1)-6alpha-Methylhydrocortisone

delta(1)-6a-Methylhydrocortisone

delta(sup 1)-6-alpha-Methylhydrocortisone

Depo-Medrol (acetate)

Dopomedrol

EINECS 201-476-4

Esametone

Firmacort

HMS1568H20

HMS2090B13

HSDB 3127

Lemod

LMST02030178

LS-118498

M0639_SIGMA

M1665

Medesone

Medixon

Medlone 21

Medrate

Medric acid

Medrol

Medrol (TN)

Medrol adt pak

Medrol Adt Pak

Medrol dosepak

Medrol Dosepak

Medrol, Solu-Medrol, Medrone, Methylprednisolone

Medrone

MEPRDL

Mesopren

Metastab

Methyleneprednisolone

Methylprednisolon

methylprednisolone

Methylprednisolone

Methylprednisolone (JP15/USP/INN)

Methylprednisolone [USAN:INN:BAN:JAN]

Methylprednisolone, 6-alpha

Methylprednisolonum

Methylprednisolonum [INN-Latin]

methylprenisolone

Metilbetasone

Metilprednisolona

Metilprednisolona [INN-Spanish]

Metilprednisolone

Metilprednisolone [Dcit]

Metilprednisolone [DCIT]

Metipred

Metrisone

Metrocort

Metysolon

MLS000028541

MLS001148159

MLS002207191

Moderin

MolPort-002-528-554

NCGC00022735-03

NCI60_001657

Nirypan

Noretona

NSC19987

NSC-19987

Predni N Tablinen

Prednol- L

Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)

Prestwick_622

Prestwick0_000279

Prestwick1_000279

Prestwick2_000279

Prestwick3_000279

Promacortine

Reactenol

S1733_Selleck

SAM002589984

Sieropresol

SMR000058330

Solomet

SPBio_002377

Summicort

Suprametil

U 7532

UNII-X4W7ZR7023

Urbason

Urbasone

Wyacort

ZINC03875560

Δ(1)-6a-methylhydrocortisone

Δ(1)-6α-methylhydrocortisone

Methylprednisolone hemisuccinate

Approved

Phase 3

2921-57-5

Prednisolone

Approved, Vet_approved

Phase 3

50-24-8

5755

Synonyms:

(11b)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

(11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione

(11Β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione

.DELTA.1-Cortisol

.DELTA.1-Dehydrocortisol

.DELTA.1-Dehydrohydrocortisone

.DELTA.1-Hydrocortisone

.delta.-Cortef

.delta.-Stab

1,2-Dehydrohydrocortisone

1,4-Pregnadiene-11b,17a,21-triol-3,20-dione

1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione

1,4-pregnadiene-11β,17α,21-triol-3,20-dione

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione

1,4-Pregnadiene-3,20-dione-11b,17a,21-triol

1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol

1,4-pregnadiene-3,20-dione-11β,17α,21-triol

1,4-Pregnadiene-3,20-dione-11β,17α,21-triol

1-Dehydrocortisol

1-Dehydrohydrocortisone

3,20-Dioxo-11b,17a,21-trihydroxy-1,4-pregnadiene

3,20-Dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene

3,20-dioxo-11β,17α,21-trihydroxy-1,4-pregnadiene

3,20-Dioxo-11β,17α,21-trihydroxy-1,4-pregnadiene

46656_FLUKA

46656_RIEDEL

50-24-8

58201-11-9

8056-11-9

AC-1773

AC1L1L2E

Ak-Pred

Ak-Tate

Alphadrol

Articulose-50

Bio-0666

BPBio1_000164

BRD-K98039984-001-03-0

BRN 1354103

BSPBio_000148

Bubbli-Pred

C07369

CCRIS 980

CHEBI:8378

CHEMBL131

CID5755

Codelcortone

Co-Hydeltra

CO-Hydeltra

component of Ataraxoid

component of K-Predne-Dome

Cordrol

Cortalone

Cotogesic

Cotolone

CPD000718761

D00472

D011239

DB00860

Decaprednil

Decortin H

Delcortol

Delta F

delta(1)-Cortisol

delta(1)-Dehydrocortisol

Delta(1)-Dehydrocortisol

delta(1)-Dehydrohydrocortisone

Delta(1)-dehydrohydrocortisone

Delta(1)-Dehydrohydrocortisone

delta(1)-Hydrocortisone

Delta(1)-Hydrocortisone

delta(sup 1)-Cortisol

delta(sup 1)-Dehydrocortisol

delta(sup 1)-Dehydrohydrocortisone

delta(sup 1)-Hydrocortisone

Delta-Cortef

Delta-Cortef (TN)

Deltacortenol

Deltacortril

Deltacortril Enteric

delta-dehydrocortisol

delta-dehydrohydrocortisone

Delta-Ef-Cortelan

delta-hydrocortisone

Deltahydrocortisone

Deltasolone

Delta-stab

Delta-Stab

Deltisilone

Depo-Medrol

Derpo Pd

Derpo PD

Dexa-Cortidelt hostacortin H

Dexa-Cortidelt Hostacortin H

Di adreson F

Di Adreson F

Di-adreson F

Di-Adreson F

Di-adreson-F

DiAdresonF

Di-Adreson-F

Dicortol

Donisolone

Dydeltrone

Eazolin D

Econopred

Econopred Plus

EINECS 200-021-7

Erbacort

Erbasona

Estilsona

Fernisolone

Fernisolone P

Fernisolone-P

Flamasone

HMS1568H10

HMS2090J05

Hostacortin H

HSDB 3385

Hydeltra

Hydeltrasol

Hydeltra-Tba

Hydeltrone

Hydrodeltalone

Hydrodeltisone

Hydroretrocortin

Hydroretrocortine

Inflamase Forte

Inflamase Mild

I-Pred

K 1557

Key-Pred

Klismacort

Lentosone

Lite Pred

LMST02030179

LS-7669

Medrol

Medrol Acetate

Metacortandralone

Methylprednisolone acetate

Methylprednisolone Acetate

Meticortelone

Meti-Derm

Metreton

MLS001304083

MLS002154250

MLS002207037

MolPort-002-507-147

M-Predrol

NCGC00179649-01

Neo-Delta-Cortef

Nisolone

Nor-Pred T.B.A.

NSC 9120

NSC9120

NSC9900

Ocu-Pred

Ocu-Pred Forte

Ophtho-Tate

Orapred

P0152_SIGMA

P0637

P6004_SIGMA

Panafcortelone

Paracortol

Paracotol

Pediapred

Poly-Pred

PRDL

Precortalon

Precortancyl

Precortilon

Precortisyl

Pred Forte

Pred Mild

Predair

Predair A

Predair Forte

Predalone 50

Predalone T.B.A.

Predate

Predate Tba

Predate-50

Predcor-25

Predcor-50

Predcor-Tba

PRED-G

Predisolone sodium phosphate

Predisolone Sodium Phosphate

Predne-Dome

Prednelan

Prednicen

Predni-Dome

Predniliderm

Predniretard

Prednis

Prednisolona

Prednisolona [INN-Spanish]

prednisolone

Prednisolone

Prednisolone (anhydrous)

Prednisolone (JP15/USP/INN)

Prednisolone [INN:BAN:JAN]

Prednisolone acetate

Prednisolone Acetate

Prednisolone sodium phosphate

Prednisolone Sodium Phosphate

Prednisolone tebutate

Prednisolone Tebutate

Prednisolonum

Prednisolonum [INN-Latin]

Predonin

Predonine

Prelone

Prenolone

Prestwick_404

Prestwick0_000274

Prestwick1_000274

Prestwick2_000274

Prestwick3_000274

Rolisone

S1737_Selleck

SAM002264639

Scherisolon

SMR000718761

Solone

SPBio_002367

Steran

Sterane

Sterolone

Supercortisol

Ulacort

Ultra Pred

Ultracorten H

Ultracortene H

Ultracortene-H

Ultracortene-hydrogen

Ultracortene-Hydrogen

UNII-9PHQ9Y1OLM

ZINC03833821

Δ(1)-dehydrocortisol

Δ(1)-dehydrohydrocortisone

Δ(1)-hydrocortisone

Δ-cortef

Prednisolone acetate

Approved, Vet_approved

Phase 3

52-21-1

Prednisolone phosphate

Approved, Vet_approved

Phase 3

302-25-0

Prednisolone hemisuccinate

Experimental

Phase 3

2920-86-7

Methylprednisolone Acetate

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone	Unknown status	NCT00004645	Phase 3
2	Efficacy and Safety Study of Vatiquinone for the Treatment of Mitochondrial Disease Subjects With Refractory Epilepsy	Recruiting	NCT04378075	Phase 2, Phase 3	Vatiquinone
3	Natural History Study of Alpers Huttenlocher Syndrome	Recruiting	NCT03034512

Search NIH Clinical Center for Balo Concentric Sclerosis

Cochrane evidence based reviews: diffuse cerebral sclerosis of schilder

Sources

Genetic Tests for Balo Concentric Sclerosis

Sources

Anatomical Context for Balo Concentric Sclerosis

MalaCards organs/tissues related to Balo Concentric Sclerosis:

⁴⁰

Spinal Cord, Brain

Sources

Publications for Balo Concentric Sclerosis

Articles related to Balo Concentric Sclerosis:

(show top 50) (show all 93)

#	Title	Authors	PMID	Year
1	Torsional nystagmus and oscillopsia as initial presentation of Balo's Concentric Sclerosis. ⁶¹	Jeeva-Patel T...Margolin E	33685544	2021
2	Balo's Concentric Sclerosis Mimicking Tumor on Magnetic Resonance Imaging in a Young Patient. ⁶¹	Hoang VT...Hoang DT	33786003	2021
3	Successful Management of Natalizumab-Associated Primary Central Nervous System Lymphoma through Autologous Stem Cell Transplant. ⁶¹	Moineau-Vallee K...Adam JP	33704187	2020
4	Descriptive neuroradiology: beyond the hummingbird. ⁶¹	Page I...Gaillard F	32855211	2020
5	Balo's concentric sclerosis: An atypical demyelinating disease in pediatrics. ⁶¹	Arenas Vargas LE...Penagos N	32531753	2020
6	Tumefactive inflammatory leukoencephalopathy in cocaine users: Report of three cases. ⁶¹	Pessini LM...Rovira A	31707217	2020
7	Why Is This Auntminnie a Diagnostic Conundrum?: A Knowledge-Based Approach to Balo's Concentric Sclerosis From Reports of 3 Cases and Pooled Data From 68 Other Patients in the Literature. ⁶¹	Agarwal M...Mark LP	29428181	2019
8	[Balo's concentric sclerosis]. ⁶¹	Kotov AS...Mukhina EV	31407690	2019
9	[Clinical and biochemical characteristics of atypical variants of multiple sclerosis]. ⁶¹	Shchepareva ME...Shabalina AA	31934992	2019
10	Balo's concentric sclerosis: an update and comprehensive literature review. ⁶¹	Amini Harandi A...Sahraian MA	29768251	2018
11	Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year. ⁶¹	Yeo CJJ...Fung SH	30228838	2018
12	Balo's concentric sclerosis in a patient with spontaneous remission based on magnetic resonance imaging: A case report and review of literature. ⁶¹	Ertugrul O...Aluclu MU	30294609	2018
13	Inaugural tumor-like multiple sclerosis: clinical presentation and medium-term outcome in 87 patients. ⁶¹	Balloy G...Societe Francophone de la Sclerose en Plaques	30054790	2018
14	7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions. ⁶¹	Behrens JR...Sinnecker T	30128315	2018
15	Balo concentric sclerosis in a 23-year-old man. ⁶¹	Yang YC...Tsai CH	30087130	2018
16	Cocaine-induced multifocal leukoencephalopathy mimicking Balo's concentric sclerosis: A 2-year follow-up with serial imaging of a single patient. ⁶¹	Sagduyu Kocaman A...Karaarslan E	29182995	2018
17	Reversible symptoms present in a patient with Balo's concentric sclerosis. ⁶¹	Dziadkowiak E...Paradowski B	29323009	2018
18	[A case-report of Balo concentric sclerosis transformed into definite multiple sclerosis]. ⁶¹	Novoselova OM...Bakhtiyarova KZ	30160676	2018
19	Multifocal Balo's Concentric Sclerosis in Children: Report of a Case and Review of Literature. ⁶¹	Bhoi SK...Misra UK	28936092	2017
20	[Atypical multiple sclerosis - Balo's concentric sclerosis: two case-reports and a review]. ⁶¹	Popova EV...Sharanova SN	28617361	2017
21	Balo concentric sclerosis: A presentation mimicking ischaemic stroke. ⁶¹	Aracil-Bolanos I...Marti-Fabregas J	25976947	2017
22	Balo's concentric lesions with concurrent features of Schilder's disease in relapsing multiple sclerosis: neuropathological findings. ⁶¹	Kurdi M...Ramsay D	28210570	2016
23	White Matter Diseases with Radiologic-Pathologic Correlation. ⁶¹	Sarbu N...Smirniotopoulos JG	27618323	2016
24	[The correlation factor analysis for conversion of clinically isolated syndrome to multiple sclerosis and neuromyelitis optica]. ⁶¹	Bi CF...Qi XK	27256609	2016
25	A 17-Year-Old Girl With Acute Onset of Hemiparesis. ⁶¹	Morrissey M...Cunningham SJ	27257741	2016
26	Early diagnosis of Balo's concentric sclerosis by diffusion tensor tractography: a case report and literature review. ⁶¹	Nader Kawachi JA...Lavenant Borja MI	27027826	2016
27	Tumefactive Demyelinating Lesions in Multiple Sclerosis and Associated Disorders. ⁶¹	Frederick MC...Cameron MH	26847090	2016
28	"Clues on Balo's concentric sclerosis evolution from serial analysis of ADC values". ⁶¹	Ripellino P...Cantello R	25405537	2016
29	Commentary on Pique et al.'s paper entitled: Peripheral late reactivation of a previously typical monofocal Balo's concentric sclerosis lesion. ⁶¹	Ciampi E...Montalban X	26014610	2015
30	Balo's Concentric Sclerosis Mimicking Cerebral Tuberculoma. ⁶¹	Son YR...Park KS	26113796	2015
31	Eccentric development of Balo's concentric sclerosis: detected by magnetic resonance diffusion-weighted imaging and magnetic resonance spectroscopy. ⁶¹	Chen F...Lu G	25051427	2015
32	Balo's Concentric Sclerosis with Acute Presentation and Co-Existing Multiple Sclerosis-Typical Lesions on MRI. ⁶¹	Purohit B...Kollias S	25873888	2015
33	ONION PEEL APPEARANCE IN BALOS CONCENTRIC SCLEROSIS--A VARIANT OF MULTIPLE SCLEROSIS. ⁶¹	Arif S...Malik H	26182786	2015
34	The etiology of ring lesions on diffusion-weighted imaging. ⁶¹	Finelli PF...Foxman EB	24976194	2014
35	Enhanced T 2 FNx weighted angiography imaging and 3-D time-resolved imaging of contrast kinetics findings in Balo's concentric sclerosis. ⁶¹	Zeng C...Ouyang Z	25033854	2014
36	Balo's concentric sclerosis. ⁶¹	Coolen AM...Setz M	25223121	2014
37	Balo concentric sclerosis in children: a case series. ⁶¹	Linnoila J...Chitnis T	24423690	2014
38	The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review. ⁶¹	Karussis D	24524923	2014
39	First use of alemtuzumab in Balo's concentric sclerosis: a case report. ⁶¹	Brown JW...Jones JL	23886830	2013
40	Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study. ⁶¹	Bolcaen J...Goethals I	23279326	2013
41	Fulminant demyelinating diseases. ⁶¹	Rahmlow MR...Kantarci O	23983890	2013
42	7 Tesla MRI demonstrates vascular pathology in Balo's concentric sclerosis. ⁶¹	Berghoff M...Gizewski ER	22641302	2013
43	A rare case of Balo concentric sclerosis showing unusual clinical improvement and response with oral prednisolone. ⁶¹	Dwivedi AN...Tripathi K	23776828	2012
44	Pathology of demyelinating diseases. ⁶¹	Popescu BF...Lucchinetti CF	22313379	2012
45	[Balo's concentric sclerosis: a rare case and the stabilization on the treatment]. ⁶¹	Serkov SV...Kornienko VN	22678683	2012
46	CADASIL mutation and Balo concentric sclerosis: a link between demyelination and ischemia? ⁶¹	Chitnis T...Hollmann TJ	22218279	2012
47	Balo's concentric sclerosis involving bilateral thalami. ⁶¹	Badar F...Rashid M	21891941	2011
48	Pitfalls in the diagnosis of a tumefactive demyelinating lesion: A case report. ⁶¹	Gavra M...Sakas D	21649896	2011
49	Balo's concentric sclerosis. ⁶¹	Hernandez-Clares R...Arroyo R	21163187	2011
50	Demyelinating lesions with features of Balo's concentric sclerosis in a patient with active hepatitis C and human herpesvirus 6 infection. ⁶¹	Ferreira D...Fonseca JM	20849439	2011

Sources

Genes for Balo Concentric Sclerosis

Genes related to Balo Concentric Sclerosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NOTCH3	Notch Receptor 3	Protein Coding	7.33	GeneCards inferred via : Publications (show sections)
2	AQP4	Aquaporin 4	Protein Coding	6.93	DISEASES inferred ¹⁵
3	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	6.34	DISEASES inferred ¹⁵
4	MBP	Myelin Basic Protein	Protein Coding	6.32	DISEASES inferred ¹⁵
5	GJC2	Gap Junction Protein Gamma 2	Protein Coding	5.89	DISEASES inferred ¹⁵
6	IFNB1	Interferon Beta 1	Protein Coding	5.86	DISEASES inferred ¹⁵
7	COPS9	COP9 Signalosome Subunit 9	Protein Coding	5.3	DISEASES inferred ¹⁵
8	GJC3	Gap Junction Protein Gamma 3	Protein Coding	5.26	DISEASES inferred ¹⁵
9	GJB6	Gap Junction Protein Beta 6	Protein Coding	5.18	DISEASES inferred ¹⁵

Sources

Variations for Balo Concentric Sclerosis

Sources

Expression for Balo Concentric Sclerosis

Search GEO for disease gene expression data for Balo Concentric Sclerosis.

Sources

Pathways for Balo Concentric Sclerosis

Sources

GO Terms for Balo Concentric Sclerosis

Cellular components related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.8	NOTCH3 MOG MBP GJC3 GJC2 GJB6
2	myelin sheath	GO:0043209	9.16	MBP GJC2
3	gap junction	GO:0005921	9.13	GJC3 GJC2 GJB6
4	connexin complex	GO:0005922	8.8	GJC3 GJC2 GJB6

Biological processes related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.5	GJC3 GJC2 GJB6
2	transmembrane transport	GO:0055085	9.46	GJC3 GJC2 GJB6 AQP4
3	maintenance of permeability of blood-brain barrier	GO:0035633	9.26	MBP GJB6
4	cell communication by electrical coupling	GO:0010644	8.96	GJC2 GJB6
5	cell communication	GO:0007154	8.8	GJC3 GJC2 GJB6

Molecular functions related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	gap junction channel activity involved in cell communication by electrical coupling	GO:1903763	8.96	GJC2 GJB6
2	gap junction channel activity	GO:0005243	8.8	GJC3 GJC2 GJB6

Sources

Sources for Balo Concentric Sclerosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia