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MCID: BLC015
MIFTS: 36

Balo Concentric Sclerosis

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Balo Concentric Sclerosis

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MalaCards integrated aliases for Balo Concentric Sclerosis:

Name: Balo Concentric Sclerosis 12 15
Balo's Concentric Sclerosis 12 77 74
Diffuse Cerebral Sclerosis of Schilder 45

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:0060215
ICD9CM 36 341.1
MeSH 45 D002549
ICD10 34 G31.81 G37.0
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Summaries for Balo Concentric Sclerosis

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Disease Ontology : 12 A demyelinating disease characterized by the fact that the demyelinated tissues form concentric layers.

MalaCards based summary : Balo Concentric Sclerosis, also known as balo's concentric sclerosis, is related to multiple sclerosis and myelinoclastic diffuse sclerosis. An important gene associated with Balo Concentric Sclerosis is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 77 Baló concentric sclerosis is a disease in which the white matter of the brain appears damaged in... more...

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Related Diseases for Balo Concentric Sclerosis

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Diseases related to Balo Concentric Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.1 AQP4 IFNB1 IL2RA MBP MOG
2 myelinoclastic diffuse sclerosis 11.8
3 mitochondrial dna depletion syndrome 4a 11.6
4 tumefactive multiple sclerosis 11.6
5 sudanophilic cerebral sclerosis 11.5
6 pelizaeus-merzbacher disease 11.5
7 adrenoleukodystrophy 11.5
8 marburg acute multiple sclerosis 11.4
9 central pontine myelinolysis 10.2 AQP4 MBP
10 allergic encephalomyelitis 10.2 MBP MOG
11 transverse myelitis 10.2 AQP4 MBP
12 panencephalitis, subacute sclerosing 10.2 MBP MOG
13 intracranial hypertension, idiopathic 10.2 AQP4 IRF6
14 autoimmune disease of peripheral nervous system 10.2 MBP MOG
15 traumatic brain injury 10.1 AQP4 MBP
16 ischemia 10.1
17 hepatitis 10.1
18 hepatitis c 10.1
19 oligodendroglioma 10.1
20 neuroretinitis 10.1 AQP4 IFNB1 MOG
21 myelitis 10.1 AQP4 MBP MOG
22 acute disseminated encephalomyelitis 10.1 AQP4 MBP MOG
23 autoimmune optic neuritis 10.1 AQP4 MBP MOG
24 optic neuritis 10.1 AQP4 MBP MOG
25 neuritis 10.1 AQP4 MBP MOG
26 neuromyelitis optica 10.1 AQP4 MBP MOG
27 cranial nerve disease 10.0 AQP4 MBP MOG
28 peripheral nervous system disease 10.0 AQP4 MBP MOG
29 primary progressive multiple sclerosis 10.0 IFNB1 MBP MOG
30 autoimmune disease 10.0 IL2RA MBP MOG
31 stroke, ischemic 10.0 AQP4 MBP NOTCH3
32 alexia 10.0 AQP4 MBP WDFY2
33 progressive multifocal leukoencephalopathy 9.9 HIF1A MBP
34 newcastle disease 9.9 HIF1A IFNB1
35 internuclear ophthalmoplegia 9.9 AQP4 IFNB1 MBP MOG
36 spinal cord disease 9.9 AQP4 IFNB1 MBP MOG
37 autoimmune disease of central nervous system 9.9 AQP4 IFNB1 MBP MOG
38 optic nerve disease 9.9 AQP4 IFNB1 MBP MOG
39 relapsing-remitting multiple sclerosis 9.9 AQP4 IFNB1 MBP MOG
40 demyelinating disease 9.9 AQP4 IFNB1 MBP MOG
41 immune system disease 9.9 AQP4 IFNB1 MBP MOG
42 nervous system disease 9.9 AQP4 IFNB1 MBP MOG
43 b-cell expansion with nfkb and t-cell anergy 9.9 IL2RA SELL
44 central nervous system disease 9.9 AQP4 IFNB1 MBP MOG
45 secondary progressive multiple sclerosis 9.9 IFNB1 MBP
46 brain cancer 9.6 AQP4 HIF1A MBP

Graphical network of the top 20 diseases related to Balo Concentric Sclerosis:



Diseases related to Balo Concentric Sclerosis
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Symptoms & Phenotypes for Balo Concentric Sclerosis

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MGI Mouse Phenotypes related to Balo Concentric Sclerosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.97 AQP4 HIF1A IL2RA IRF6 MBP MOG
2 hematopoietic system MP:0005397 9.91 AQP4 GPR182 HIF1A IFNB1 IL2RA MBP
3 immune system MP:0005387 9.76 AQP4 HIF1A IFNB1 IL2RA MBP MOG
4 hearing/vestibular/ear MP:0005377 9.62 AQP4 IRF6 MBP NOTCH3
5 respiratory system MP:0005388 9.35 AQP4 HIF1A IL2RA NOTCH3 SELL
6 vision/eye MP:0005391 9.1 AQP4 HIF1A IL2RA MBP MOG NOTCH3
Sources

Drugs & Therapeutics for Balo Concentric Sclerosis

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Drugs for Balo Concentric Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
6 Prednisolone acetate Phase 3
7 Peripheral Nervous System Agents Phase 3
8 Anti-Inflammatory Agents Phase 3
9 Hormones Phase 3
10 Autonomic Agents Phase 3
11 Hormone Antagonists Phase 3
12 Antiemetics Phase 3
13 Methylprednisolone Acetate Phase 3
14 Neuroprotective Agents Phase 3
15 Gastrointestinal Agents Phase 3
16 glucocorticoids Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
18 Protective Agents Phase 3
19
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
20
rituximab Approved Phase 2 174722-31-7 10201696
21
alemtuzumab Approved, Investigational Phase 2 216503-57-0
22
Lenograstim Approved, Investigational Phase 2 135968-09-1
23
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
24
Mesna Approved, Investigational Phase 2 3375-50-6 598
25 Antirheumatic Agents Phase 2
26 Immunologic Factors Phase 2
27 Alkylating Agents Phase 2
28 Antineoplastic Agents, Immunological Phase 2
29 Immunosuppressive Agents Phase 2
30 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis Recruiting NCT03630211 Phase 2 Cyclophosphamide;Mesna;Rituximab;Alemtuzumab;Thiotepa;GM-CSF
3 Alpers Huttenlocher Natural History Study Recruiting NCT03034512

Search NIH Clinical Center for Balo Concentric Sclerosis

Cochrane evidence based reviews: diffuse cerebral sclerosis of schilder

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Genetic Tests for Balo Concentric Sclerosis

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Anatomical Context for Balo Concentric Sclerosis

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MalaCards organs/tissues related to Balo Concentric Sclerosis:

42
Brain, Spinal Cord
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Publications for Balo Concentric Sclerosis

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Articles related to Balo Concentric Sclerosis:

(show top 50) (show all 55)
# Title Authors Year
1
Balo concentric sclerosis in a 23-year-old man. ( 30087130 )
2018
2
7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions. ( 30128315 )
2018
3
Cocaine-induced multifocal leukoencephalopathy mimicking Balo's concentric sclerosis: A 2-year follow-up with serial imaging of a single patient. ( 29182995 )
2018
4
Reversible symptoms present in a patient with Balo's concentric sclerosis. ( 29323009 )
2018
5
Baló's concentric sclerosis is immunologically distinct from multiple sclerosis: results from retrospective analysis of almost 150 lumbar punctures. ( 29347989 )
2018
6
Why Is This Auntminnie a Diagnostic Conundrum?: A Knowledge-Based Approach to Balo's Concentric Sclerosis From Reports of 3 Cases and Pooled Data From 68 Other Patients in the Literature. ( 29428181 )
2018
7
Balo's concentric sclerosis: an update and comprehensive literature review. ( 29768251 )
2018
8
Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year. ( 30228838 )
2018
9
Balo's concentric sclerosis in a patient with spontaneous remission based on magnetic resonance imaging: A case report and review of literature. ( 30294609 )
2018
10
Multifocal Balo's Concentric Sclerosis in Children: Report of a Case and Review of Literature. ( 28936092 )
2017
11
Exploring the overlap between multiple sclerosis, tumefactive demyelination and Baló's concentric sclerosis. ( 27037180 )
2016
12
Morphogenesis of the demyelinating lesions in Baló's concentric sclerosis. ( 27142145 )
2016
13
"Clues on Balo's concentric sclerosis evolution from serial analysis of ADC values". ( 25405537 )
2016
14
Early diagnosis of Balo's concentric sclerosis by diffusion tensor tractography: a case report and literature review. ( 27027826 )
2016
15
Eccentric development of Balo's concentric sclerosis: detected by magnetic resonance diffusion-weighted imaging and magnetic resonance spectroscopy. ( 25051427 )
2015
16
Balo concentric sclerosis: A presentation mimicking ischaemic stroke. ( 25976947 )
2015
17
Combination treatment of interferon β-1b and warfarin for a patient with Baló's concentric sclerosis and antiphospholipid syndrome. ( 25607332 )
2015
18
Serial magnetic resonance imaging representation in a Baló's concentric sclerosis. ( 25641388 )
2015
19
Balo's Concentric Sclerosis with Acute Presentation and Co-Existing Multiple Sclerosis-Typical Lesions on MRI. ( 25873888 )
2015
20
Commentary on Pique et al.'s paper entitled: Peripheral late reactivation of a previously typical monofocal Balo's concentric sclerosis lesion. ( 26014610 )
2015
21
Balò's concentric sclerosis: still to be considered as a variant of multiple sclerosis? ( 26109007 )
2015
22
Balo's Concentric Sclerosis Mimicking Cerebral Tuberculoma. ( 26113796 )
2015
23
Balo concentric sclerosis in children: a case series. ( 24423690 )
2014
24
Baló's concentric sclerosis. ( 24943346 )
2014
25
Enhanced T 2 FNx weighted angiography imaging and 3-D time-resolved imaging of contrast kinetics findings in Balo's concentric sclerosis. ( 25033854 )
2014
26
Balo's concentric sclerosis. ( 25223121 )
2014
27
First use of alemtuzumab in Balo's concentric sclerosis: a case report. ( 23886830 )
2013
28
7 Tesla MRI demonstrates vascular pathology in Balo's concentric sclerosis. ( 22641302 )
2013
29
A rare case of Balo concentric sclerosis showing unusual clinical improvement and response with oral prednisolone. ( 23776828 )
2012
30
CADASIL mutation and Balo concentric sclerosis: a link between demyelination and ischemia? ( 22218279 )
2012
31
Balo's concentric sclerosis. ( 21163187 )
2011
32
Balo's concentric sclerosis involving bilateral thalami. ( 21891941 )
2011
33
Demyelinating lesions with features of Balo's concentric sclerosis in a patient with active hepatitis C and human herpesvirus 6 infection. ( 20849439 )
2011
34
Balo's concentric sclerosis. ( 20630582 )
2010
35
Spinal cord involvement in Balo's concentric sclerosis. ( 19181346 )
2009
36
Serial proton MR spectroscopy and diffusion tensor imaging in infantile Balo's concentric sclerosis. ( 18958461 )
2009
37
Magnetic Resonance Imaging in Balo's Concentric Sclerosis. A Case Report. ( 24256821 )
2008
38
Diffusion-weighted imaging findings in Balo concentric sclerosis. ( 16823051 )
2006
39
Successful pregnancy of a patient with Balo's concentric sclerosis. ( 15957519 )
2005
40
Diffusion abnormality in Balo's concentric sclerosis: clues for the pathogenesis. ( 15746544 )
2005
41
Balo's concentric sclerosis. Evolution of active demyelination demonstrated by serial contrast-enhanced MRI. ( 12140661 )
2002
42
Balo's concentric sclerosis demonstrated by contrast MRI. ( 11706100 )
2001
43
Pathognomonic MR imaging findings in Balo concentric sclerosis. ( 11156771 )
2001
44
MRI features of Balo's concentric sclerosis. ( 10474505 )
1999
45
Balo's concentric sclerosis: value of magnetic resonance imaging in diagnosis. ( 10901949 )
1999
46
Serial magnetic resonance imaging (MRI) study of a patient with Balo's concentric sclerosis treated with immunoadsorption plasmapheresis. ( 9065920 )
1997
47
Balo's concentric sclerosis: a clinical case study of brain MRI, biopsy, and proton magnetic resonance spectroscopic findings. ( 9219760 )
1997
48
Balo's concentric sclerosis. Report of two patients with magnetic resonance imaging follow-up. ( 8634495 )
1996
49
Treatment of Balo's concentric sclerosis with immunosuppressive drugs followed by multimodality evoked potentials and MRI. ( 7477074 )
1995
50
Balo's concentric sclerosis: a rare form of multiple sclerosis manifested as a dominant cerebral mass without other white matter lesions on MR. ( 8456698 )
1993
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Variations for Balo Concentric Sclerosis

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Expression for Balo Concentric Sclerosis

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Search GEO for disease gene expression data for Balo Concentric Sclerosis.
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Pathways for Balo Concentric Sclerosis

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Pathways related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.86 IL2RA NOTCH3 SELL
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GO Terms for Balo Concentric Sclerosis

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Cellular components related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 AQP4 IL2RA MOG SELL

Biological processes related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.13 HIF1A IFNB1 IL2RA
2 cell surface receptor signaling pathway GO:0007166 8.8 GPR182 IFNB1 IL2RA
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Sources for Balo Concentric Sclerosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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