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MCID: BLC015
MIFTS: 33

Balo Concentric Sclerosis

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Balo Concentric Sclerosis

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MalaCards integrated aliases for Balo Concentric Sclerosis:

Name: Balo Concentric Sclerosis 12 15
Balo's Concentric Sclerosis 12 76 73
Diffuse Cerebral Sclerosis of Schilder 44

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:0060215
ICD10 33 G31.81 G37.0
ICD9CM 35 341.1
MeSH 44 D002549
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Summaries for Balo Concentric Sclerosis

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Disease Ontology : 12 A demyelinating disease characterized by the fact that the demyelinated tissues form concentric layers.

MalaCards based summary : Balo Concentric Sclerosis, also known as balo's concentric sclerosis, is related to tumefactive multiple sclerosis and myelinoclastic diffuse sclerosis. An important gene associated with Balo Concentric Sclerosis is NOTCH3 (Notch 3), and among its related pathways/superpathways are Th17 cell differentiation and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Prednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related phenotypes are hematopoietic system and growth/size/body region

Wikipedia : 76 Balo concentric sclerosis is a disease in which the white matter of the brain appears damaged in... more...

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Related Diseases for Balo Concentric Sclerosis

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Diseases related to Balo Concentric Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 tumefactive multiple sclerosis 11.9
2 myelinoclastic diffuse sclerosis 11.8
3 mitochondrial dna depletion syndrome 4a 11.6
4 adrenoleukodystrophy 11.6
5 sudanophilic cerebral sclerosis 11.5
6 pelizaeus-merzbacher disease 11.5
7 marburg acute multiple sclerosis 11.4
8 central pontine myelinolysis 10.1 AQP4 MBP
9 transverse myelitis 10.1 AQP4 MBP
10 ischemia 10.1
11 traumatic brain injury 10.1 AQP4 MBP
12 allergic encephalomyelitis 10.1 MBP MOG
13 panencephalitis, subacute sclerosing 10.1 MBP MOG
14 autoimmune disease of peripheral nervous system 10.0 MBP MOG
15 stroke, ischemic 10.0 AQP4 MBP NOTCH3
16 viral encephalitis 10.0 MBP MOG
17 b-cell expansion with nfkb and t-cell anergy 10.0 IL2RA SELL
18 secondary progressive multiple sclerosis 10.0 IFNB1 MBP
19 neuroretinitis 10.0 AQP4 IFNB1 MOG
20 alexia 10.0 AQP4 MBP WDFY2
21 progressive multifocal leukoencephalopathy 10.0 HIF1A MBP
22 myelitis 10.0 AQP4 MBP MOG
23 acute disseminated encephalomyelitis 10.0 AQP4 MBP MOG
24 autoimmune optic neuritis 10.0 AQP4 MBP MOG
25 optic neuritis 10.0 AQP4 MBP MOG
26 neuritis 10.0 AQP4 MBP MOG
27 neuromyelitis optica 10.0 AQP4 MBP MOG
28 autoimmune disease 10.0 IL2RA MBP MOG
29 cranial nerve disease 10.0 AQP4 MBP MOG
30 peripheral nervous system disease 9.9 AQP4 MBP MOG
31 primary progressive multiple sclerosis 9.9 IFNB1 MBP MOG
32 vascular dementia 9.9 MBP NOTCH3
33 internuclear ophthalmoplegia 9.9 AQP4 IFNB1 MBP MOG
34 spinal cord disease 9.9 AQP4 IFNB1 MBP MOG
35 autoimmune disease of central nervous system 9.9 AQP4 IFNB1 MBP MOG
36 autoimmune disease of the nervous system 9.9 AQP4 IFNB1 MBP MOG
37 optic nerve disease 9.9 AQP4 IFNB1 MBP MOG
38 relapsing-remitting multiple sclerosis 9.9 AQP4 IFNB1 MBP MOG
39 immune system disease 9.9 AQP4 IFNB1 MBP MOG
40 demyelinating disease 9.8 AQP4 IFNB1 MBP MOG
41 nervous system disease 9.8 AQP4 IFNB1 MBP MOG
42 central nervous system disease 9.8 AQP4 IFNB1 MBP MOG
43 brain cancer 9.8 AQP4 HIF1A MBP
44 multiple sclerosis 9.7 AQP4 IFNB1 IL2RA MBP MOG

Graphical network of the top 20 diseases related to Balo Concentric Sclerosis:



Diseases related to Balo Concentric Sclerosis
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Symptoms & Phenotypes for Balo Concentric Sclerosis

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MGI Mouse Phenotypes related to Balo Concentric Sclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 AQP4 GPR182 HIF1A IFNB1 IL2RA MBP
2 growth/size/body region MP:0005378 9.87 AQP4 HIF1A IL2RA MBP MOG NOTCH3
3 immune system MP:0005387 9.76 AQP4 HIF1A IFNB1 IL2RA MBP MOG
4 respiratory system MP:0005388 9.35 AQP4 HIF1A IL2RA NOTCH3 SELL
5 vision/eye MP:0005391 9.1 AQP4 HIF1A IL2RA MBP MOG NOTCH3
Sources

Drugs & Therapeutics for Balo Concentric Sclerosis

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Drugs for Balo Concentric Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
2
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
3
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
6 Methylprednisolone acetate Phase 3
7 Protective Agents Phase 3
8 Prednisolone acetate Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Hormone Antagonists Phase 3
12 Gastrointestinal Agents Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 glucocorticoids Phase 3
15 Hormones Phase 3
16 Autonomic Agents Phase 3
17 Antiemetics Phase 3
18 Neuroprotective Agents Phase 3
19
Lenograstim Approved, Investigational Phase 2 135968-09-1
20
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
21
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
22
rituximab Approved Phase 2 174722-31-7 10201696
23
Mesna Approved, Investigational Phase 2 3375-50-6 598
24
alemtuzumab Approved, Investigational Phase 2 216503-57-0
25 Antineoplastic Agents, Alkylating Phase 2
26 Alkylating Agents Phase 2
27 Antirheumatic Agents Phase 2
28 Immunologic Factors Phase 2
29 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis Recruiting NCT03630211 Phase 2 Cyclophosphamide;Mesna;Rituximab;Alemtuzumab;Thiotepa;GM-CSF
3 Alpers Huttenlocher Natural History Study Recruiting NCT03034512

Search NIH Clinical Center for Balo Concentric Sclerosis

Cochrane evidence based reviews: diffuse cerebral sclerosis of schilder

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Genetic Tests for Balo Concentric Sclerosis

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Anatomical Context for Balo Concentric Sclerosis

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MalaCards organs/tissues related to Balo Concentric Sclerosis:

41
Brain, Spinal Cord, T Cells, B Cells
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Publications for Balo Concentric Sclerosis

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Articles related to Balo Concentric Sclerosis:

(show top 50) (show all 56)
# Title Authors Year
1
Balo concentric sclerosis in a 23-year-old man. ( 30087130 )
2018
2
7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions. ( 30128315 )
2018
3
Cocaine-induced multifocal leukoencephalopathy mimicking Balo's concentric sclerosis: A 2-year follow-up with serial imaging of a single patient. ( 29182995 )
2018
4
Reversible symptoms present in a patient with Balo's concentric sclerosis. ( 29323009 )
2018
5
Baló's concentric sclerosis is immunologically distinct from multiple sclerosis: results from retrospective analysis of almost 150 lumbar punctures. ( 29347989 )
2018
6
Why Is This Auntminnie a Diagnostic Conundrum?: A Knowledge-Based Approach to Balo's Concentric Sclerosis From Reports of 3 Cases and Pooled Data From 68 Other Patients in the Literature. ( 29428181 )
2018
7
Balo's concentric sclerosis: an update and comprehensive literature review. ( 29768251 )
2018
8
Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year. ( 30228838 )
2018
9
Balo's concentric sclerosis in a patient with spontaneous remission based on magnetic resonance imaging: A case report and review of literature. ( 30294609 )
2018
10
Multifocal Balo's Concentric Sclerosis in Children: Report of a Case and Review of Literature. ( 28936092 )
2017
11
"Clues on Balo's concentric sclerosis evolution from serial analysis of ADC values". ( 25405537 )
2016
12
Early diagnosis of Balo's concentric sclerosis by diffusion tensor tractography: a case report and literature review. ( 27027826 )
2016
13
Exploring the overlap between multiple sclerosis, tumefactive demyelination and Baló's concentric sclerosis. ( 27037180 )
2016
14
Morphogenesis of the demyelinating lesions in Baló's concentric sclerosis. ( 27142145 )
2016
15
Eccentric development of Balo's concentric sclerosis: detected by magnetic resonance diffusion-weighted imaging and magnetic resonance spectroscopy. ( 25051427 )
2015
16
Balo concentric sclerosis: A presentation mimicking ischaemic stroke. ( 25976947 )
2015
17
Combination treatment of interferon β-1b and warfarin for a patient with Baló's concentric sclerosis and antiphospholipid syndrome. ( 25607332 )
2015
18
Serial magnetic resonance imaging representation in a Baló's concentric sclerosis. ( 25641388 )
2015
19
Balo's Concentric Sclerosis with Acute Presentation and Co-Existing Multiple Sclerosis-Typical Lesions on MRI. ( 25873888 )
2015
20
Commentary on Pique et al.'s paper entitled: Peripheral late reactivation of a previously typical monofocal Balo's concentric sclerosis lesion. ( 26014610 )
2015
21
Balò's concentric sclerosis: still to be considered as a variant of multiple sclerosis? ( 26109007 )
2015
22
Balo's Concentric Sclerosis Mimicking Cerebral Tuberculoma. ( 26113796 )
2015
23
Balo concentric sclerosis in children: a case series. ( 24423690 )
2014
24
Baló's concentric sclerosis. ( 24943346 )
2014
25
Enhanced T 2 FNx weighted angiography imaging and 3-D time-resolved imaging of contrast kinetics findings in Balo's concentric sclerosis. ( 25033854 )
2014
26
Balo's concentric sclerosis. ( 25223121 )
2014
27
First use of alemtuzumab in Balo's concentric sclerosis: a case report. ( 23886830 )
2013
28
7 Tesla MRI demonstrates vascular pathology in Balo's concentric sclerosis. ( 22641302 )
2013
29
A rare case of Balo concentric sclerosis showing unusual clinical improvement and response with oral prednisolone. ( 23776828 )
2012
30
CADASIL mutation and Balo concentric sclerosis: a link between demyelination and ischemia? ( 22218279 )
2012
31
Balo's concentric sclerosis. ( 21163187 )
2011
32
Balo's concentric sclerosis involving bilateral thalami. ( 21891941 )
2011
33
Demyelinating lesions with features of Balo's concentric sclerosis in a patient with active hepatitis C and human herpesvirus 6 infection. ( 20849439 )
2011
34
Balo's concentric sclerosis. ( 20630582 )
2010
35
Spinal cord involvement in Balo's concentric sclerosis. ( 19181346 )
2009
36
Serial proton MR spectroscopy and diffusion tensor imaging in infantile Balo's concentric sclerosis. ( 18958461 )
2009
37
Magnetic Resonance Imaging in Balo's Concentric Sclerosis. A Case Report. ( 24256821 )
2008
38
Diffusion-weighted imaging findings in Balo concentric sclerosis. ( 16823051 )
2006
39
Successful pregnancy of a patient with Balo's concentric sclerosis. ( 15957519 )
2005
40
Diffusion abnormality in Balo's concentric sclerosis: clues for the pathogenesis. ( 15746544 )
2005
41
Balo's concentric sclerosis. Evolution of active demyelination demonstrated by serial contrast-enhanced MRI. ( 12140661 )
2002
42
Balo's concentric sclerosis demonstrated by contrast MRI. ( 11706100 )
2001
43
Pathognomonic MR imaging findings in Balo concentric sclerosis. ( 11156771 )
2001
44
MRI features of Balo's concentric sclerosis. ( 10474505 )
1999
45
Balo's concentric sclerosis: value of magnetic resonance imaging in diagnosis. ( 10901949 )
1999
46
Baló's concentric sclerosis in a 4-year-old Japanese infant. ( 9661972 )
1998
47
Serial magnetic resonance imaging (MRI) study of a patient with Balo's concentric sclerosis treated with immunoadsorption plasmapheresis. ( 9065920 )
1997
48
Balo's concentric sclerosis: a clinical case study of brain MRI, biopsy, and proton magnetic resonance spectroscopic findings. ( 9219760 )
1997
49
Balo's concentric sclerosis. Report of two patients with magnetic resonance imaging follow-up. ( 8634495 )
1996
50
Treatment of Balo's concentric sclerosis with immunosuppressive drugs followed by multimodality evoked potentials and MRI. ( 7477074 )
1995
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Variations for Balo Concentric Sclerosis

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Expression for Balo Concentric Sclerosis

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Search GEO for disease gene expression data for Balo Concentric Sclerosis.
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Pathways for Balo Concentric Sclerosis

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Pathways related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Th17 cell differentiation 37
Show member pathways
 11.67 HIF1A IL2RA NOTCH3
2
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
10.86 IL2RA NOTCH3 SELL
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GO Terms for Balo Concentric Sclerosis

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Cellular components related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 AQP4 IL2RA MOG SELL

Biological processes related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.13 HIF1A IFNB1 IL2RA
2 cell surface receptor signaling pathway GO:0007166 8.8 GPR182 IFNB1 IL2RA
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Sources for Balo Concentric Sclerosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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