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MCID: BLC015
MIFTS: 38

Balo Concentric Sclerosis

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Balo Concentric Sclerosis

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MalaCards integrated aliases for Balo Concentric Sclerosis:

Name: Balo Concentric Sclerosis 12 15
Balo's Concentric Sclerosis 12 77 74
Diffuse Cerebral Sclerosis of Schilder 45

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:0060215
ICD9CM 36 341.1
MeSH 45 D002549
ICD10 34 G31.81 G37.0
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Summaries for Balo Concentric Sclerosis

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Disease Ontology : 12 A demyelinating disease characterized by the fact that the demyelinated tissues form concentric layers.

MalaCards based summary : Balo Concentric Sclerosis, also known as balo's concentric sclerosis, is related to multiple sclerosis and myelinoclastic diffuse sclerosis. An important gene associated with Balo Concentric Sclerosis is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 77 Baló concentric sclerosis is a disease in which the white matter of the brain appears damaged in... more...

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Related Diseases for Balo Concentric Sclerosis

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Diseases related to Balo Concentric Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.1 AQP4 IFNB1 IL2RA MBP MOG
2 myelinoclastic diffuse sclerosis 11.8
3 mitochondrial dna depletion syndrome 4a 11.7
4 tumefactive multiple sclerosis 11.6
5 sudanophilic cerebral sclerosis 11.5
6 pelizaeus-merzbacher disease 11.5
7 adrenoleukodystrophy 11.5
8 marburg acute multiple sclerosis 11.4
9 central pontine myelinolysis 10.2 AQP4 MBP
10 allergic encephalomyelitis 10.2 MBP MOG
11 transverse myelitis 10.2 AQP4 MBP
12 panencephalitis, subacute sclerosing 10.2 MBP MOG
13 intracranial hypertension, idiopathic 10.2 AQP4 IRF6
14 autoimmune disease of peripheral nervous system 10.2 MBP MOG
15 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.1
16 ischemia 10.1
17 traumatic brain injury 10.1 AQP4 MBP
18 hepatitis 10.1
19 hepatitis c 10.1
20 oligodendroglioma 10.1
21 neuroretinitis 10.1 AQP4 IFNB1 MOG
22 myelitis 10.1 AQP4 MBP MOG
23 acute disseminated encephalomyelitis 10.1 AQP4 MBP MOG
24 autoimmune optic neuritis 10.1 AQP4 MBP MOG
25 optic neuritis 10.1 AQP4 MBP MOG
26 neuritis 10.1 AQP4 MBP MOG
27 neuromyelitis optica 10.1 AQP4 MBP MOG
28 cranial nerve disease 10.0 AQP4 MBP MOG
29 peripheral nervous system disease 10.0 AQP4 MBP MOG
30 primary progressive multiple sclerosis 10.0 IFNB1 MBP MOG
31 autoimmune disease 10.0 IL2RA MBP MOG
32 stroke, ischemic 10.0 AQP4 MBP NOTCH3
33 alexia 10.0 AQP4 MBP WDFY2
34 progressive multifocal leukoencephalopathy 9.9 HIF1A MBP
35 newcastle disease 9.9 HIF1A IFNB1
36 internuclear ophthalmoplegia 9.9 AQP4 IFNB1 MBP MOG
37 spinal cord disease 9.9 AQP4 IFNB1 MBP MOG
38 autoimmune disease of central nervous system 9.9 AQP4 IFNB1 MBP MOG
39 optic nerve disease 9.9 AQP4 IFNB1 MBP MOG
40 relapsing-remitting multiple sclerosis 9.9 AQP4 IFNB1 MBP MOG
41 demyelinating disease 9.9 AQP4 IFNB1 MBP MOG
42 immune system disease 9.9 AQP4 IFNB1 MBP MOG
43 nervous system disease 9.9 AQP4 IFNB1 MBP MOG
44 b-cell expansion with nfkb and t-cell anergy 9.9 IL2RA SELL
45 central nervous system disease 9.9 AQP4 IFNB1 MBP MOG
46 secondary progressive multiple sclerosis 9.9 IFNB1 MBP
47 brain cancer 9.6 AQP4 HIF1A MBP

Graphical network of the top 20 diseases related to Balo Concentric Sclerosis:



Diseases related to Balo Concentric Sclerosis
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Symptoms & Phenotypes for Balo Concentric Sclerosis

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MGI Mouse Phenotypes related to Balo Concentric Sclerosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.97 AQP4 HIF1A IL2RA IRF6 MBP MOG
2 hematopoietic system MP:0005397 9.91 AQP4 GPR182 HIF1A IFNB1 IL2RA MBP
3 immune system MP:0005387 9.76 AQP4 HIF1A IFNB1 IL2RA MBP MOG
4 hearing/vestibular/ear MP:0005377 9.62 AQP4 IRF6 MBP NOTCH3
5 respiratory system MP:0005388 9.35 AQP4 HIF1A IL2RA NOTCH3 SELL
6 vision/eye MP:0005391 9.1 AQP4 HIF1A IL2RA MBP MOG NOTCH3
Sources

Drugs & Therapeutics for Balo Concentric Sclerosis

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Drugs for Balo Concentric Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
6 Gastrointestinal Agents Phase 3
7 Hormone Antagonists Phase 3
8 glucocorticoids Phase 3
9 Protective Agents Phase 3
10 Peripheral Nervous System Agents Phase 3
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
12 Anti-Inflammatory Agents Phase 3
13 Antiemetics Phase 3
14 Methylprednisolone Acetate Phase 3
15 Prednisolone acetate Phase 3
16 Hormones Phase 3
17 Autonomic Agents Phase 3
18 Neuroprotective Agents Phase 3
19
alemtuzumab Approved, Investigational Phase 2 216503-57-0
20
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
21
Lenograstim Approved, Investigational Phase 2 135968-09-1
22
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
23
Mesna Approved, Investigational Phase 2 3375-50-6 598
24
rituximab Approved Phase 2 174722-31-7 10201696
25 Immunoglobulins, Intravenous Phase 2
26 Antineoplastic Agents, Immunological Phase 2
27 Immunoglobulins Phase 2
28 Immunologic Factors Phase 2
29 Alkylating Agents Phase 2
30 Immunosuppressive Agents Phase 2
31 Antirheumatic Agents Phase 2
32 gamma-Globulins Phase 2
33 Rho(D) Immune Globulin Phase 2
34 Antibodies Phase 2
35 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis Recruiting NCT03630211 Phase 2 Cyclophosphamide;Mesna;Rituximab;Alemtuzumab;Thiotepa;GM-CSF;Intravenous immunoglobulin
3 Alpers Huttenlocher Natural History Study Recruiting NCT03034512

Search NIH Clinical Center for Balo Concentric Sclerosis

Cochrane evidence based reviews: diffuse cerebral sclerosis of schilder

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Genetic Tests for Balo Concentric Sclerosis

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Anatomical Context for Balo Concentric Sclerosis

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MalaCards organs/tissues related to Balo Concentric Sclerosis:

42
Brain, Spinal Cord, T Cells, B Cells
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Publications for Balo Concentric Sclerosis

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Articles related to Balo Concentric Sclerosis:

(show top 50) (show all 89)
# Title Authors Year
1
Pediatric Baló Concentric Sclerosis Response to Dimethyl Fumarate. ( 31047755 )
2019
2
MRI study of Baló's concentric sclerosis before and after corticosteroid therapy. ( 30948263 )
2019
3
Elevated lipid peaks during the recovery phase of Baló's concentric sclerosis: A case report. ( 31049421 )
2019
4
Balo concentric sclerosis in a 23-year-old man. ( 30087130 )
2018
5
7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions. ( 30128315 )
2018
6
Cocaine-induced multifocal leukoencephalopathy mimicking Balo's concentric sclerosis: A 2-year follow-up with serial imaging of a single patient. ( 29182995 )
2018
7
Reversible symptoms present in a patient with Balo's concentric sclerosis. ( 29323009 )
2018
8
Baló's concentric sclerosis is immunologically distinct from multiple sclerosis: results from retrospective analysis of almost 150 lumbar punctures. ( 29347989 )
2018
9
Why Is This Auntminnie a Diagnostic Conundrum?: A Knowledge-Based Approach to Balo's Concentric Sclerosis From Reports of 3 Cases and Pooled Data From 68 Other Patients in the Literature. ( 29428181 )
2018
10
Balo's concentric sclerosis: an update and comprehensive literature review. ( 29768251 )
2018
11
Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year. ( 30228838 )
2018
12
Balo's concentric sclerosis in a patient with spontaneous remission based on magnetic resonance imaging: A case report and review of literature. ( 30294609 )
2018
13
Balo concentric sclerosis: A presentation mimicking ischaemic stroke. ( 25976947 )
2017
14
Baló concentric sclerosis evolving from apparent tumefactive demyelination. ( 28468846 )
2017
15
Baló concentric sclerosis evolving from apparent tumefactive demyelination. ( 28739667 )
2017
16
Multifocal Balo's Concentric Sclerosis in Children: Report of a Case and Review of Literature. ( 28936092 )
2017
17
"Clues on Balo's concentric sclerosis evolution from serial analysis of ADC values". ( 25405537 )
2016
18
Early diagnosis of Balo's concentric sclerosis by diffusion tensor tractography: a case report and literature review. ( 27027826 )
2016
19
Exploring the overlap between multiple sclerosis, tumefactive demyelination and Baló's concentric sclerosis. ( 27037180 )
2016
20
Morphogenesis of the demyelinating lesions in Baló's concentric sclerosis. ( 27142145 )
2016
21
Combination treatment of interferon β-1b and warfarin for a patient with Baló's concentric sclerosis and antiphospholipid syndrome. ( 25607332 )
2015
22
Teaching NeuroImages: Acute neurologic deficits due to Baló concentric sclerosis. ( 25847002 )
2015
23
Eccentric development of Balo's concentric sclerosis: detected by magnetic resonance diffusion-weighted imaging and magnetic resonance spectroscopy. ( 25051427 )
2015
24
Baló's concentric sclerosis and tumefactive demyelination: a shared immunopathogenesis? ( 25475150 )
2015
25
Serial magnetic resonance imaging representation in a Baló's concentric sclerosis. ( 25641388 )
2015
26
Balo's Concentric Sclerosis with Acute Presentation and Co-Existing Multiple Sclerosis-Typical Lesions on MRI. ( 25873888 )
2015
27
Peripheral late reactivation of a previously typical monofocal Baló's concentric sclerosis lesion. ( 26014609 )
2015
28
Commentary on Pique et al.'s paper entitled: Peripheral late reactivation of a previously typical monofocal Balo's concentric sclerosis lesion. ( 26014610 )
2015
29
Balò's concentric sclerosis: still to be considered as a variant of multiple sclerosis? ( 26109007 )
2015
30
Balo's Concentric Sclerosis Mimicking Cerebral Tuberculoma. ( 26113796 )
2015
31
Balo concentric sclerosis in children: a case series. ( 24423690 )
2014
32
Baló's concentric sclerosis. ( 24943346 )
2014
33
Enhanced T 2 FNx weighted angiography imaging and 3-D time-resolved imaging of contrast kinetics findings in Balo's concentric sclerosis. ( 25033854 )
2014
34
Balo's concentric sclerosis. ( 25223121 )
2014
35
Mystery case: Baló concentric sclerosis. ( 23400322 )
2013
36
7 Tesla MRI demonstrates vascular pathology in Balo's concentric sclerosis. ( 22641302 )
2013
37
Basic and advanced imaging of a case of Balò's concentric sclerosis. ( 23355596 )
2013
38
First use of alemtuzumab in Balo's concentric sclerosis: a case report. ( 23886830 )
2013
39
Baló's concentric sclerosis in a girl with interesting presentation. ( 24250927 )
2013
40
Baló's concentric sclerosis: imaging findings and pathological correlation. ( 24421937 )
2013
41
CADASIL mutation and Balo concentric sclerosis: a link between demyelination and ischemia? ( 22218279 )
2012
42
A rare case of Balo concentric sclerosis showing unusual clinical improvement and response with oral prednisolone. ( 23776828 )
2012
43
Baló's concentric sclerosis in multiple sclerosis. ( 22864141 )
2012
44
Balo's concentric sclerosis involving bilateral thalami. ( 21891941 )
2011
45
Demyelinating lesions with features of Balo's concentric sclerosis in a patient with active hepatitis C and human herpesvirus 6 infection. ( 20849439 )
2011
46
Balo's concentric sclerosis. ( 21163187 )
2011
47
Images in clinical medicine. Baló's concentric sclerosis. ( 21864168 )
2011
48
Balo's concentric sclerosis. ( 20630582 )
2010
49
Serial proton MR spectroscopy and diffusion tensor imaging in infantile Balo's concentric sclerosis. ( 18958461 )
2009
50
Spinal cord involvement in Balo's concentric sclerosis. ( 19181346 )
2009
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Variations for Balo Concentric Sclerosis

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Expression for Balo Concentric Sclerosis

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Search GEO for disease gene expression data for Balo Concentric Sclerosis.
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Pathways for Balo Concentric Sclerosis

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Pathways related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.86 IL2RA NOTCH3 SELL
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GO Terms for Balo Concentric Sclerosis

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Cellular components related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 AQP4 IL2RA MOG SELL

Biological processes related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.13 HIF1A IFNB1 IL2RA
2 cell surface receptor signaling pathway GO:0007166 8.8 GPR182 IFNB1 IL2RA
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Sources for Balo Concentric Sclerosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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