MCID: BLC015
MIFTS: 37

Balo Concentric Sclerosis

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Balo Concentric Sclerosis

MalaCards integrated aliases for Balo Concentric Sclerosis:

Name: Balo Concentric Sclerosis 12 58 15
Balo's Concentric Sclerosis 12 73 20 70
Diffuse Cerebral Sclerosis of Schilder 20 44 70
Balo Disease 12 73 20
Tumefactive Multiple Sclerosis 12 20
Concentric Demyelination 20 58
Encephalitis Periaxialis Concentrica 20
Baló Concentric Sclerosis 20
Marburg Variant 20
Balo's Disease 20

Characteristics:

Orphanet epidemiological data:

58
balo concentric sclerosis
Inheritance: Multigenic/multifactorial; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0060215
ICD9CM 34 341.1
MeSH 44 D002549
NCIt 50 C84670
SNOMED-CT 67 44875002
ICD10 32 G37.0
ICD10 via Orphanet 33 G37.5
UMLS via Orphanet 71 C0004712
Orphanet 58 ORPHA228165
UMLS 70 C0004712 C0007795

Summaries for Balo Concentric Sclerosis

GARD : 20 Tumefactive multiple sclerosis is characterized by a tumor -like lesion larger than two centimeters and signs and symptoms similar to those of a brain tumor. It is a rare form of multiple sclerosis (MS). Symptoms of tumefactive MS often differ from other MS cases and may include, headaches, changes in thinking, confusion, speech problems, seizures, and weakness. The cause of tumefactive MS is not known. It often develops into the relapsing-remitting form of MS. In other cases there is only one occurrence of the condition. In still others the disease process remains less clear. While there is no cure for tumefactive MS, treatments such as corticosteroids are available to decrease disease activity.

MalaCards based summary : Balo Concentric Sclerosis, also known as balo's concentric sclerosis, is related to optic neuritis and neuritis. An important gene associated with Balo Concentric Sclerosis is NOTCH3 (Notch Receptor 3). The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A multiple sclerosis that is characterized by concentric layers of demyelinated tissues, tumor-like lesions larger than two centimeters and symptoms similar to those of a brain tumor.

Wikipedia : 73 Baló's concentric sclerosis is a disease in which the white matter of the brain appears damaged in... more...

Related Diseases for Balo Concentric Sclerosis

Diseases related to Balo Concentric Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 optic neuritis 30.4 MOG MBP AQP4
2 neuritis 30.4 MOG MBP AQP4
3 neurosarcoidosis 30.2 MOG AQP4
4 demyelinating disease 30.2 MOG MBP IFNB1 AQP4
5 relapsing-remitting multiple sclerosis 30.0 MOG MBP IFNB1 AQP4
6 neuromyelitis optica 29.9 MOG MBP AQP4
7 encephalitis 29.8 MOG IFNB1 AQP4
8 acute disseminated encephalomyelitis 29.8 MOG MBP IFNB1 AQP4
9 myelitis 29.8 MOG MBP IFNB1 AQP4
10 progressive multifocal leukoencephalopathy 29.8 MBP IFNB1
11 multiple sclerosis 29.6 NOTCH3 MOG MBP IFNB1 AQP4
12 internuclear ophthalmoplegia 29.6 MOG MBP IFNB1 AQP4
13 mitochondrial dna depletion syndrome 4a 11.7
14 myelinoclastic diffuse sclerosis 11.5
15 pelizaeus-merzbacher disease 11.4
16 adrenoleukodystrophy 11.4
17 marburg acute multiple sclerosis 11.3
18 glioma 10.4
19 glial tumor 10.4
20 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.2
21 ischemia 10.2
22 dysphagia 10.2
23 vascular myelopathy 10.2 MOG AQP4
24 hemiplegia 10.2
25 hepatitis c 10.2
26 pulmonary tuberculosis 10.2
27 oligodendroglioma 10.2
28 cocaine abuse 10.2
29 pathologic nystagmus 10.2
30 optic papillitis 10.2 MOG AQP4
31 acute retrobulbar neuritis 10.1 MBP AQP4
32 allergic encephalomyelitis 10.1 MOG MBP
33 color agnosia 10.1 MBP AQP4
34 glioma susceptibility 1 10.1
35 malignant astrocytoma 10.1
36 high grade glioma 10.1
37 central nervous system lymphoma 10.1
38 oligoastrocytoma 10.1
39 primary central nervous system lymphoma 10.1
40 acute hemorrhagic leukoencephalitis 10.1 MBP AQP4
41 traumatic brain injury 10.1 MBP AQP4
42 brain injury 10.1 MBP AQP4
43 covid-19 10.1
44 chromosome 18q deletion syndrome 10.1 MBP GJC2
45 guillain-barre syndrome 10.0 MOG MBP
46 subacute sclerosing panencephalitis 10.0 MOG MBP
47 leukoencephalopathy, hereditary diffuse, with spheroids 10.0 NOTCH3 MBP
48 autoimmune optic neuritis 10.0 MOG MBP AQP4
49 syringomyelia, noncommunicating isolated 10.0
50 sudanophilic cerebral sclerosis 10.0

Comorbidity relations with Balo Concentric Sclerosis via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Balo Concentric Sclerosis:



Diseases related to Balo Concentric Sclerosis

Symptoms & Phenotypes for Balo Concentric Sclerosis

MGI Mouse Phenotypes related to Balo Concentric Sclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 AQP4 GJC2 GJC3 IFNB1 MBP MOG
2 immune system MP:0005387 9.76 AQP4 GJB6 GJC2 GJC3 IFNB1 MBP
3 hearing/vestibular/ear MP:0005377 9.72 AQP4 GJB6 GJC3 MBP NOTCH3
4 nervous system MP:0003631 9.56 AQP4 GJB6 GJC2 GJC3 IFNB1 MBP
5 vision/eye MP:0005391 9.1 AQP4 GJC2 GJC3 MBP MOG NOTCH3

Drugs & Therapeutics for Balo Concentric Sclerosis

Drugs for Balo Concentric Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
5
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
6
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
7 Methylprednisolone Acetate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
2 Efficacy and Safety Study of Vatiquinone for the Treatment of Mitochondrial Disease Subjects With Refractory Epilepsy Recruiting NCT04378075 Phase 2, Phase 3 Vatiquinone
3 Natural History Study of Alpers Huttenlocher Syndrome Recruiting NCT03034512

Search NIH Clinical Center for Balo Concentric Sclerosis

Cochrane evidence based reviews: diffuse cerebral sclerosis of schilder

Genetic Tests for Balo Concentric Sclerosis

Anatomical Context for Balo Concentric Sclerosis

MalaCards organs/tissues related to Balo Concentric Sclerosis:

40
Spinal Cord, Brain

Publications for Balo Concentric Sclerosis

Articles related to Balo Concentric Sclerosis:

(show top 50) (show all 93)
# Title Authors PMID Year
1
Torsional nystagmus and oscillopsia as initial presentation of Balo's Concentric Sclerosis. 61
33685544 2021
2
Balo's Concentric Sclerosis Mimicking Tumor on Magnetic Resonance Imaging in a Young Patient. 61
33786003 2021
3
Successful Management of Natalizumab-Associated Primary Central Nervous System Lymphoma through Autologous Stem Cell Transplant. 61
33704187 2020
4
Descriptive neuroradiology: beyond the hummingbird. 61
32855211 2020
5
Balo's concentric sclerosis: An atypical demyelinating disease in pediatrics. 61
32531753 2020
6
Tumefactive inflammatory leukoencephalopathy in cocaine users: Report of three cases. 61
31707217 2020
7
Why Is This Auntminnie a Diagnostic Conundrum?: A Knowledge-Based Approach to Balo's Concentric Sclerosis From Reports of 3 Cases and Pooled Data From 68 Other Patients in the Literature. 61
29428181 2019
8
[Balo's concentric sclerosis]. 61
31407690 2019
9
[Clinical and biochemical characteristics of atypical variants of multiple sclerosis]. 61
31934992 2019
10
Balo's concentric sclerosis: an update and comprehensive literature review. 61
29768251 2018
11
Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year. 61
30228838 2018
12
Balo's concentric sclerosis in a patient with spontaneous remission based on magnetic resonance imaging: A case report and review of literature. 61
30294609 2018
13
Inaugural tumor-like multiple sclerosis: clinical presentation and medium-term outcome in 87 patients. 61
30054790 2018
14
7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions. 61
30128315 2018
15
Balo concentric sclerosis in a 23-year-old man. 61
30087130 2018
16
Cocaine-induced multifocal leukoencephalopathy mimicking Balo's concentric sclerosis: A 2-year follow-up with serial imaging of a single patient. 61
29182995 2018
17
Reversible symptoms present in a patient with Balo's concentric sclerosis. 61
29323009 2018
18
[A case-report of Balo concentric sclerosis transformed into definite multiple sclerosis]. 61
30160676 2018
19
Multifocal Balo's Concentric Sclerosis in Children: Report of a Case and Review of Literature. 61
28936092 2017
20
[Atypical multiple sclerosis - Balo's concentric sclerosis: two case-reports and a review]. 61
28617361 2017
21
Balo concentric sclerosis: A presentation mimicking ischaemic stroke. 61
25976947 2017
22
Balo's concentric lesions with concurrent features of Schilder's disease in relapsing multiple sclerosis: neuropathological findings. 61
28210570 2016
23
White Matter Diseases with Radiologic-Pathologic Correlation. 61
27618323 2016
24
[The correlation factor analysis for conversion of clinically isolated syndrome to multiple sclerosis and neuromyelitis optica]. 61
27256609 2016
25
A 17-Year-Old Girl With Acute Onset of Hemiparesis. 61
27257741 2016
26
Early diagnosis of Balo's concentric sclerosis by diffusion tensor tractography: a case report and literature review. 61
27027826 2016
27
Tumefactive Demyelinating Lesions in Multiple Sclerosis and Associated Disorders. 61
26847090 2016
28
"Clues on Balo's concentric sclerosis evolution from serial analysis of ADC values". 61
25405537 2016
29
Commentary on Pique et al.'s paper entitled: Peripheral late reactivation of a previously typical monofocal Balo's concentric sclerosis lesion. 61
26014610 2015
30
Balo's Concentric Sclerosis Mimicking Cerebral Tuberculoma. 61
26113796 2015
31
Eccentric development of Balo's concentric sclerosis: detected by magnetic resonance diffusion-weighted imaging and magnetic resonance spectroscopy. 61
25051427 2015
32
Balo's Concentric Sclerosis with Acute Presentation and Co-Existing Multiple Sclerosis-Typical Lesions on MRI. 61
25873888 2015
33
ONION PEEL APPEARANCE IN BALOS CONCENTRIC SCLEROSIS--A VARIANT OF MULTIPLE SCLEROSIS. 61
26182786 2015
34
The etiology of ring lesions on diffusion-weighted imaging. 61
24976194 2014
35
Enhanced T 2 FNx weighted angiography imaging and 3-D time-resolved imaging of contrast kinetics findings in Balo's concentric sclerosis. 61
25033854 2014
36
Balo's concentric sclerosis. 61
25223121 2014
37
Balo concentric sclerosis in children: a case series. 61
24423690 2014
38
The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review. 61
24524923 2014
39
First use of alemtuzumab in Balo's concentric sclerosis: a case report. 61
23886830 2013
40
Structural and metabolic features of two different variants of multiple sclerosis: a PET/MRI study. 61
23279326 2013
41
Fulminant demyelinating diseases. 61
23983890 2013
42
7 Tesla MRI demonstrates vascular pathology in Balo's concentric sclerosis. 61
22641302 2013
43
A rare case of Balo concentric sclerosis showing unusual clinical improvement and response with oral prednisolone. 61
23776828 2012
44
Pathology of demyelinating diseases. 61
22313379 2012
45
[Balo's concentric sclerosis: a rare case and the stabilization on the treatment]. 61
22678683 2012
46
CADASIL mutation and Balo concentric sclerosis: a link between demyelination and ischemia? 61
22218279 2012
47
Balo's concentric sclerosis involving bilateral thalami. 61
21891941 2011
48
Pitfalls in the diagnosis of a tumefactive demyelinating lesion: A case report. 61
21649896 2011
49
Balo's concentric sclerosis. 61
21163187 2011
50
Demyelinating lesions with features of Balo's concentric sclerosis in a patient with active hepatitis C and human herpesvirus 6 infection. 61
20849439 2011

Variations for Balo Concentric Sclerosis

Expression for Balo Concentric Sclerosis

Search GEO for disease gene expression data for Balo Concentric Sclerosis.

Pathways for Balo Concentric Sclerosis

GO Terms for Balo Concentric Sclerosis

Cellular components related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.8 NOTCH3 MOG MBP GJC3 GJC2 GJB6
2 myelin sheath GO:0043209 9.16 MBP GJC2
3 gap junction GO:0005921 9.13 GJC3 GJC2 GJB6
4 connexin complex GO:0005922 8.8 GJC3 GJC2 GJB6

Biological processes related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.5 GJC3 GJC2 GJB6
2 transmembrane transport GO:0055085 9.46 GJC3 GJC2 GJB6 AQP4
3 maintenance of permeability of blood-brain barrier GO:0035633 9.26 MBP GJB6
4 cell communication by electrical coupling GO:0010644 8.96 GJC2 GJB6
5 cell communication GO:0007154 8.8 GJC3 GJC2 GJB6

Molecular functions related to Balo Concentric Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity involved in cell communication by electrical coupling GO:1903763 8.96 GJC2 GJB6
2 gap junction channel activity GO:0005243 8.8 GJC3 GJC2 GJB6

Sources for Balo Concentric Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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