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MCID: BRB003
MIFTS: 27

Barbiturate Abuse

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Barbiturate Abuse

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MalaCards integrated aliases for Barbiturate Abuse:

Name: Barbiturate Abuse 12 15

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8519
ICD9CM 34 305.43
ICD10 32 F13.11
UMLS 71 C0154529
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Summaries for Barbiturate Abuse

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Disease Ontology : 12 A substance abuse that involves the recurring use of barbiturate drugs despite negative consequences.

MalaCards based summary : Barbiturate Abuse is related to alcohol dependence and cataract 25. An important gene associated with Barbiturate Abuse is SLC18A1 (Solute Carrier Family 18 Member A1), and among its related pathways/superpathways are Circadian entrainment and Amphetamine addiction. Affiliated tissues include brain, and related phenotypes are behavior/neurological and digestive/alimentary

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Related Diseases for Barbiturate Abuse

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Diseases related to Barbiturate Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 alcohol dependence 28.6 SLC18A2 OPRM1 MAOB MAOA HCRT
2 cataract 25 10.4 WASF3 WASF1
3 dependent personality disorder 10.4 WASF2 WASF1
4 histrionic personality disorder 10.3 WASF2 WASF1
5 narcissistic personality disorder 10.3 WASF2 WASF1
6 paranoid personality disorder 10.3 WASF2 WASF1
7 schizoid personality disorder 10.3 WASF2 WASF1
8 obsessive-compulsive personality disorder 10.3 WASF2 WASF1
9 pyromania 10.3 WASF1 MAOA
10 hallucinogen dependence 10.3 WASF2 WASF1
11 spinocerebellar ataxia, autosomal recessive 3 10.2 WASF3 WASF2 WASF1
12 schizotypal personality disorder 10.2 WASF2 WASF1
13 atypical depressive disorder 10.2 MAOB MAOA
14 pure autonomic failure 10.1 MAOB MAOA
15 neonatal abstinence syndrome 10.1 OPRM1 CLMP
16 avoidant personality disorder 10.1 WASF2 WASF1 MAOA
17 serotonin syndrome 10.1 MAOB MAOA
18 phobia, specific 10.1 WASF2 WASF1 MAOA
19 phobic disorder 10.1 WASF2 WASF1 MAOA
20 agoraphobia 10.1 WASF2 WASF1 MAOA
21 social phobia 10.1 WASF2 WASF1 MAOA
22 opioid abuse 10.1 OPRM1 CLMP
23 mental depression 10.1 WASF2 WASF1 MAOA
24 barbiturate dependence 10.0 OPRM1 MIR155HG
25 brunner syndrome 10.0 MAOB MAOA
26 cannabis dependence 10.0 WASF2 WASF1 HCRT
27 pathological gambling 10.0 WASF1 MAOB MAOA
28 status epilepticus 10.0
29 wiskott-aldrich syndrome 9.9 WASF3 WASF2 WASF1
30 separation anxiety disorder 9.9 WASF2 WASF1 OPRM1
31 cannabis abuse 9.9 WASF2 WASF1 OPRM1
32 ring dermoid of cornea 9.9 WASF2 WASF1
33 oppositional defiant disorder 9.9 WASF3 WASF2 WASF1 MAOA
34 vagus nerve disease 9.9 ATP4A ATP12A
35 hemangioma of intra-abdominal structure 9.9 ATP4A ATP12A
36 acquired gastric outlet stenosis 9.9 ATP4A ATP12A
37 displacement of cardia through esophageal hiatus 9.9 ATP4A ATP12A
38 angiodysplasia of intestine 9.9 ATP4A ATP12A
39 angiodysplasia 9.9 ATP4A ATP12A
40 benzylpenicillin allergy 9.9 ATP4A ATP12A
41 penicillin allergy 9.9 ATP4A ATP12A
42 granulomatous gastritis 9.9 ATP4A ATP12A
43 bacterial esophagitis 9.9 ATP4A ATP12A
44 alcohol use disorder 9.9 WASF2 WASF1 OPRM1
45 lingual goiter 9.9 ATP4A ATP12A
46 cascade stomach 9.9 ATP4A ATP12A
47 gastrojejunal ulcer 9.9 ATP4A ATP12A
48 median arcuate ligament syndrome 9.9 ATP4A ATP12A
49 laryngeal tuberculosis 9.9 ATP4A ATP12A
50 fungal esophagitis 9.9 ATP4A ATP12A

Graphical network of the top 20 diseases related to Barbiturate Abuse:



Diseases related to Barbiturate Abuse
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Symptoms & Phenotypes for Barbiturate Abuse

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MGI Mouse Phenotypes related to Barbiturate Abuse:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ATP12A CLMP HCRT IGBP1 MAOA MAOB
2 digestive/alimentary MP:0005381 9.5 ATP12A ATP4A CLMP OPRM1 SLC18A2 WASF1
3 nervous system MP:0003631 9.32 HCRT IGBP1 MAOA MAOB MLST8 OPRM1
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Drugs & Therapeutics for Barbiturate Abuse

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Search Clinical Trials , NIH Clinical Center for Barbiturate Abuse

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Genetic Tests for Barbiturate Abuse

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Anatomical Context for Barbiturate Abuse

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MalaCards organs/tissues related to Barbiturate Abuse:

40
Brain
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Publications for Barbiturate Abuse

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Articles related to Barbiturate Abuse:

(show all 16)
# Title Authors PMID Year
1
Transient diffuse cerebral hypoperfusion in Tc-99m HMPAO SPECT of the brain during withdrawal syndrome following acute barbiturate poisoning. 61
12458639 2002
2
Is a history of alcohol problems or of psychiatric disorder associated with attrition at 11-year follow-up? 61
8827158 1996
3
Severe barbiturate withdrawal syndrome in migrainous patients. 61
8742687 1996
4
[Capsular retraction of the hip]. 61
8333704 1993
5
Nonconvulsive status epilepticus and barbiturate abuse. 61
3601101 1987
6
Epileptiform abnormalities discovered on electroencephalographic screening of psychiatric inpatients. 61
2881532 1987
7
[EEG changes in the withdrawal phase of tranquilizer or drug abuse]. 61
3084203 1986
8
Analytical aspects of barbiturate abuse: identification of drugs by the effective combination of gas-liquid, high-performance liquid and thin-layer chromatographic techniques. 61
7217255 1981
9
Barbiturate abuse. 61
7432278 1980
10
Fatal hyperthermia following haloperidol therapy of sedative-hypnotic withdrawal. 61
681307 1978
11
Barbiturate abuse. 61
940139 1976
12
Drug addiction in pregnancy and the neonate. 61
1266895 1976
13
Barbiturate abuse-a growing broblem. 61
1161516 1975
14
Diazepam, alcohol, and barbiturate abuse. 61
5124414 1971
15
Barbiturate abuse and addiction and their relationship to alcohol and alcoholism. 61
4924250 1971
16
New developments in barbiturate abuse. 61
5520390 1970
Sources

Variations for Barbiturate Abuse

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Expression for Barbiturate Abuse

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Search GEO for disease gene expression data for Barbiturate Abuse.
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Pathways for Barbiturate Abuse

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Pathways related to Barbiturate Abuse according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Circadian entrainment 36
Show member pathways
 12.45 SLC18A2 SLC18A1 MAOB MAOA
2
Amphetamine addiction 36
Show member pathways
 11.53 SLC18A2 SLC18A1 MAOB MAOA
3
Fc gamma R-mediated phagocytosis 36
11.47 WASF3 WASF2 WASF1
4
Serotonergic synapse 36
11.32 SLC18A2 SLC18A1 MAOB MAOA
5
Adherens junction 36
11.28 WASF3 WASF2 WASF1
6
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 60
10.94 SLC18A2 MAOA
7
Sympathetic Nerve Pathway (Neuroeffector Junction) 60
10.82 SLC18A2 SLC18A1
8
noradrenaline and adrenaline degradation 1
Show member pathways
 10.64 MAOB MAOA
9
Dopamine metabolism 1
10.55 MAOB MAOA
10
putrescine degradation III 1
Show member pathways
 10.48 MAOB MAOA
11
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.16 SLC18A2 MAOB MAOA
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GO Terms for Barbiturate Abuse

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Cellular components related to Barbiturate Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynapse GO:0098794 9.33 WASF3 WASF1 HCRT
2 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 8.96 SLC18A2 SLC18A1
3 SCAR complex GO:0031209 8.8 WASF3 WASF2 WASF1

Biological processes related to Barbiturate Abuse according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 eating behavior GO:0042755 9.54 OPRM1 HCRT
2 Rac protein signal transduction GO:0016601 9.52 WASF2 WASF1
3 cellular sodium ion homeostasis GO:0006883 9.51 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.49 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 9.48 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.46 ATP4A ATP12A
7 neurotransmitter catabolic process GO:0042135 9.43 MAOB MAOA
8 dopamine catabolic process GO:0042420 9.4 MAOB MAOA
9 monoamine transport GO:0015844 9.37 SLC18A2 SLC18A1
10 modification of postsynaptic actin cytoskeleton GO:0098885 9.32 WASF3 WASF1
11 lamellipodium morphogenesis GO:0072673 9.26 WASF2 WASF1
12 aminergic neurotransmitter loading into synaptic vesicle GO:0015842 9.16 SLC18A2 SLC18A1
13 serotonin uptake GO:0051610 8.96 SLC18A2 SLC18A1
14 positive regulation of Arp2/3 complex-mediated actin nucleation GO:2000601 8.8 WASF3 WASF2 WASF1

Molecular functions related to Barbiturate Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase A binding GO:0051018 9.46 WASF2 WASF1
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.43 ATP4A ATP12A
3 potassium-transporting ATPase activity GO:0008556 9.4 ATP4A ATP12A
4 monoamine transmembrane transporter activity GO:0008504 9.37 SLC18A2 SLC18A1
5 primary amine oxidase activity GO:0008131 9.32 MAOB MAOA
6 potassium:proton exchanging ATPase activity GO:0008900 9.26 ATP4A ATP12A
7 serotonin:sodium symporter activity GO:0005335 9.16 SLC18A2 SLC18A1
8 protein kinase A regulatory subunit binding GO:0034237 9.13 WASF3 WASF2 WASF1
9 Arp2/3 complex binding GO:0071933 8.8 WASF3 WASF2 WASF1
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Sources for Barbiturate Abuse

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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