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MCID: BRB003
MIFTS: 28

Barbiturate Abuse

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Barbiturate Abuse

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MalaCards integrated aliases for Barbiturate Abuse:

Name: Barbiturate Abuse 12 15

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8519
ICD9CM 34 305.43
ICD10 32 F13.11
UMLS 71 C0154529
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Summaries for Barbiturate Abuse

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Disease Ontology : 12 A substance abuse that involves the recurring use of barbiturate drugs despite negative consequences.

MalaCards based summary : Barbiturate Abuse is related to alcohol dependence and cataract 25. An important gene associated with Barbiturate Abuse is CLMP (CXADR Like Membrane Protein), and among its related pathways/superpathways are Circadian entrainment and Amphetamine addiction. Affiliated tissues include brain, skin and cervix, and related phenotypes are behavior/neurological and digestive/alimentary

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Related Diseases for Barbiturate Abuse

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Diseases related to Barbiturate Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 alcohol dependence 29.5 SLC18A2 MAOB MAOA HCRT
2 cataract 25 10.4 WASF3 WASF1
3 extracranial neuroblastoma 10.4 SLC18A2 SLC18A1
4 dependent personality disorder 10.4 WASF2 WASF1
5 histrionic personality disorder 10.4 WASF2 WASF1
6 narcissistic personality disorder 10.4 WASF2 WASF1
7 paranoid personality disorder 10.4 WASF2 WASF1
8 schizoid personality disorder 10.4 WASF2 WASF1
9 obsessive-compulsive personality disorder 10.4 WASF2 WASF1
10 hallucinogen dependence 10.3 WASF2 WASF1
11 separation anxiety disorder 10.3 WASF2 WASF1
12 cannabis abuse 10.3 WASF2 WASF1
13 atypical depressive disorder 10.2 MAOB MAOA
14 monkeypox 10.2 CLMP CD4
15 schizotypal personality disorder 10.2 WASF2 WASF1
16 pure autonomic failure 10.2 MAOB MAOA
17 trichomoniasis 10.2 WASF3 CD4
18 serotonin syndrome 10.2 MAOB MAOA
19 avoidant personality disorder 10.2 WASF2 WASF1 MAOA
20 phobia, specific 10.1 WASF2 WASF1 MAOA
21 phobic disorder 10.1 WASF2 WASF1 MAOA
22 agoraphobia 10.1 WASF2 WASF1 MAOA
23 social phobia 10.1 WASF2 WASF1 MAOA
24 brunner syndrome 10.1 MAOB MAOA
25 mental depression 10.1 WASF2 WASF1 MAOA
26 geotrichosis 10.1 CD4 CARTPT
27 cystoisosporiasis 10.1 CD4 CARTPT
28 substance dependence 10.1 WASF2 WASF1 MAOA
29 impulse control disorder 10.1 WASF1 MAOB MAOA
30 pathological gambling 10.1 WASF1 MAOB MAOA
31 wiskott-aldrich syndrome 10.0 WASF3 WASF2 WASF1
32 fungal meningitis 10.0 CD4 CARTPT
33 cocaine abuse 10.0 SLC18A2 MAOB CARTPT
34 oppositional defiant disorder 10.0 WASF3 WASF2 WASF1 MAOA
35 tobacco addiction 10.0 WASF3 WASF2 WASF1 MAOA
36 toxic encephalopathy 10.0 SLC18A2 MAOB CARTPT
37 status epilepticus 9.9
38 hypophosphatasia, infantile 9.9 CD4 CARTPT
39 anus cancer 9.9 CD4 CARTPT
40 narcolepsy 9.9 SLC18A2 SLC18A1 MAOA HCRT
41 antisocial personality disorder 9.8 WASF2 WASF1 MAOB MAOA
42 mood disorder 9.8 SLC18A2 MAOB MAOA
43 psychotic disorder 9.8 SLC18A2 MAOB MAOA
44 pancreatic vasoactive intestinal peptide producing tumor 9.8 ATP4A ATP12A
45 hemangioma of intra-abdominal structure 9.8 ATP4A ATP12A
46 displacement of cardia through esophageal hiatus 9.8 ATP4A ATP12A
47 gastric hemangioma 9.8 ATP4A ATP12A
48 acquired gastric outlet stenosis 9.8 ATP4A ATP12A
49 disease of mental health 9.8 WASF2 WASF1 MAOA HCRT
50 angiodysplasia of intestine 9.8 ATP4A ATP12A

Graphical network of the top 20 diseases related to Barbiturate Abuse:



Diseases related to Barbiturate Abuse
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Symptoms & Phenotypes for Barbiturate Abuse

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MGI Mouse Phenotypes related to Barbiturate Abuse:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 ATP12A CARTPT CLMP HCRT MAOA MAOB
2 digestive/alimentary MP:0005381 9.7 ATP12A ATP4A CD4 CLMP SLC18A2 WASF1
3 homeostasis/metabolism MP:0005376 9.65 ATP12A ATP4A CARTPT CD4 CLMP HCRT
4 nervous system MP:0003631 9.28 CD4 HCRT MAOA MAOB MLST8 SLC18A1
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Drugs & Therapeutics for Barbiturate Abuse

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Search Clinical Trials , NIH Clinical Center for Barbiturate Abuse

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Genetic Tests for Barbiturate Abuse

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Anatomical Context for Barbiturate Abuse

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MalaCards organs/tissues related to Barbiturate Abuse:

40
Brain, Skin, Cervix
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Publications for Barbiturate Abuse

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Articles related to Barbiturate Abuse:

(show all 16)
# Title Authors PMID Year
1
Transient diffuse cerebral hypoperfusion in Tc-99m HMPAO SPECT of the brain during withdrawal syndrome following acute barbiturate poisoning. 61
12458639 2002
2
Is a history of alcohol problems or of psychiatric disorder associated with attrition at 11-year follow-up? 61
8827158 1996
3
Severe barbiturate withdrawal syndrome in migrainous patients. 61
8742687 1996
4
[Capsular retraction of the hip]. 61
8333704 1993
5
Nonconvulsive status epilepticus and barbiturate abuse. 61
3601101 1987
6
Epileptiform abnormalities discovered on electroencephalographic screening of psychiatric inpatients. 61
2881532 1987
7
[EEG changes in the withdrawal phase of tranquilizer or drug abuse]. 61
3084203 1986
8
Analytical aspects of barbiturate abuse: identification of drugs by the effective combination of gas-liquid, high-performance liquid and thin-layer chromatographic techniques. 61
7217255 1981
9
Barbiturate abuse. 61
7432278 1980
10
Fatal hyperthermia following haloperidol therapy of sedative-hypnotic withdrawal. 61
681307 1978
11
Barbiturate abuse. 61
940139 1976
12
Drug addiction in pregnancy and the neonate. 61
1266895 1976
13
Barbiturate abuse-a growing broblem. 61
1161516 1975
14
Diazepam, alcohol, and barbiturate abuse. 61
5124414 1971
15
Barbiturate abuse and addiction and their relationship to alcohol and alcoholism. 61
4924250 1971
16
New developments in barbiturate abuse. 61
5520390 1970
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Variations for Barbiturate Abuse

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Expression for Barbiturate Abuse

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Search GEO for disease gene expression data for Barbiturate Abuse.
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Pathways for Barbiturate Abuse

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Pathways related to Barbiturate Abuse according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Circadian entrainment 36
Show member pathways
 12.47 SLC18A2 SLC18A1 MAOB MAOA
2
Amphetamine addiction 36
Show member pathways
 11.53 SLC18A2 SLC18A1 MAOB MAOA
3
Fc gamma R-mediated phagocytosis 36
11.47 WASF3 WASF2 WASF1
4
Serotonergic synapse 36
11.32 SLC18A2 SLC18A1 MAOB MAOA
5
Adherens junction 36
11.28 WASF3 WASF2 WASF1
6
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 60
10.92 SLC18A2 MAOA
7
Sympathetic Nerve Pathway (Neuroeffector Junction) 60
10.82 SLC18A2 SLC18A1
8
noradrenaline and adrenaline degradation 1
Show member pathways
 10.61 MAOB MAOA
9
Dopamine metabolism 1
10.55 MAOB MAOA
10
putrescine degradation III 1
Show member pathways
 10.48 MAOB MAOA
11
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.16 SLC18A2 MAOB MAOA
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GO Terms for Barbiturate Abuse

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Cellular components related to Barbiturate Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 9.55 WASF2 WASF1 SLC18A1 HCRT CARTPT
2 SCAR complex GO:0031209 8.96 WASF2 WASF1
3 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 8.62 SLC18A2 SLC18A1

Biological processes related to Barbiturate Abuse according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 actin filament polymerization GO:0030041 9.51 WASF3 WASF1
2 Rac protein signal transduction GO:0016601 9.49 WASF2 WASF1
3 cellular sodium ion homeostasis GO:0006883 9.48 ATP4A ATP12A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.46 ATP4A ATP12A
5 sodium ion export across plasma membrane GO:0036376 9.43 ATP4A ATP12A
6 cellular potassium ion homeostasis GO:0030007 9.4 ATP4A ATP12A
7 neurotransmitter catabolic process GO:0042135 9.37 MAOB MAOA
8 dopamine catabolic process GO:0042420 9.32 MAOB MAOA
9 monoamine transport GO:0015844 9.26 SLC18A2 SLC18A1
10 positive regulation of transmission of nerve impulse GO:0051971 9.16 HCRT CARTPT
11 aminergic neurotransmitter loading into synaptic vesicle GO:0015842 8.96 SLC18A2 SLC18A1
12 serotonin uptake GO:0051610 8.62 SLC18A2 SLC18A1

Molecular functions related to Barbiturate Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.43 HCRT CARTPT
2 protein kinase A binding GO:0051018 9.4 WASF2 WASF1
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP4A ATP12A
4 potassium-transporting ATPase activity GO:0008556 9.32 ATP4A ATP12A
5 monoamine transmembrane transporter activity GO:0008504 9.26 SLC18A2 SLC18A1
6 primary amine oxidase activity GO:0008131 9.16 MAOB MAOA
7 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
8 serotonin:sodium symporter activity GO:0005335 8.62 SLC18A2 SLC18A1
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Sources for Barbiturate Abuse

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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