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MCID: BRB003
MIFTS: 25

Barbiturate Abuse

Categories: Mental diseases
Genes Related diseases Publications Pathways
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Aliases & Classifications for Barbiturate Abuse

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MalaCards integrated aliases for Barbiturate Abuse:

Name: Barbiturate Abuse 12 15

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8519
ICD9CM 34 305.43
ICD10 32 F13.11
UMLS 71 C0154529
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Summaries for Barbiturate Abuse

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Disease Ontology : 12 A substance abuse that involves the recurring use of barbiturate drugs despite negative consequences.

MalaCards based summary : Barbiturate Abuse is related to alcohol dependence and tic disorder. An important gene associated with Barbiturate Abuse is SLC18A1 (Solute Carrier Family 18 Member A1), and among its related pathways/superpathways are Prion disease and Circadian entrainment. Related phenotypes are behavior/neurological and nervous system

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Related Diseases for Barbiturate Abuse

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Diseases related to Barbiturate Abuse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 alcohol dependence 28.8 SLC18A2 POMC OPRM1 MAOB MAOA HCRT
2 tic disorder 10.3 SLC18A2 MAOA
3 separation anxiety disorder 10.2 OPRM1 MAOA
4 pure autonomic failure 10.1 MAOB MAOA
5 serotonin syndrome 10.1 MAOB MAOA
6 neurotic disorder 10.1 POMC MAOA
7 motion sickness 10.1 POMC OPRM1
8 brunner syndrome 10.1 MAOB MAOA
9 opioid abuse 10.1 POMC OPRM1
10 heroin dependence 10.1 OPRM1 MAOA
11 melancholia 10.1 POMC MAOA
12 morphine dependence 10.1 OPRM1 HCRT
13 aromatic l-amino acid decarboxylase deficiency 10.1 SLC18A2 MAOB
14 rem sleep behavior disorder 10.1 SLC18A2 HCRT
15 phobic disorder 10.1 POMC MAOA
16 hypothalamic disease 10.1 POMC HCRT
17 adjustment disorder 10.0 POMC HCRT
18 amnestic disorder 10.0 POMC OPRM1
19 opiate dependence 10.0 POMC OPRM1
20 impulse control disorder 10.0 OPRM1 MAOB MAOA
21 pathological gambling 10.0 OPRM1 MAOB MAOA
22 antisocial personality disorder 10.0 MAOB MAOA
23 hepatic encephalopathy 10.0 OPRM1 MAOB MAOA
24 status epilepticus 9.9
25 substance abuse 9.9 POMC OPRM1 MAOA
26 substance dependence 9.9 POMC OPRM1 MAOA
27 dementia, lewy body 9.9 SLC18A2 MAOB HCRT
28 atypical depressive disorder 9.9 POMC MAOB MAOA
29 post-traumatic stress disorder 9.9 POMC MAOB MAOA
30 withdrawal disorder 9.9 POMC OPRM1 HCRT
31 endogenous depression 9.9 POMC MAOA
32 eating disorder 9.9 POMC OPRM1 HCRT
33 vagus nerve disease 9.9 ATP4A ATP12A
34 necrotizing gastritis 9.9 ATP4A ATP12A
35 scalp dermatosis 9.9 ATP4A ATP12A
36 hemangioma of intra-abdominal structure 9.9 ATP4A ATP12A
37 dysthymic disorder 9.9 POMC MAOA HCRT
38 acquired gastric outlet stenosis 9.9 ATP4A ATP12A
39 lingual goiter 9.9 ATP4A ATP12A
40 displacement of cardia through esophageal hiatus 9.9 ATP4A ATP12A
41 bacterial esophagitis 9.9 ATP4A ATP12A
42 cascade stomach 9.9 ATP4A ATP12A
43 benzylpenicillin allergy 9.9 ATP4A ATP12A
44 median arcuate ligament syndrome 9.9 ATP4A ATP12A
45 afferent loop syndrome 9.9 ATP4A ATP12A
46 cervix erosion 9.9 ATP4A ATP12A
47 angiodysplasia of intestine 9.9 ATP4A ATP12A
48 angiodysplasia 9.9 ATP4A ATP12A
49 granulomatous gastritis 9.9 ATP4A ATP12A
50 laryngeal tuberculosis 9.9 ATP4A ATP12A

Graphical network of the top 20 diseases related to Barbiturate Abuse:



Diseases related to Barbiturate Abuse
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Symptoms & Phenotypes for Barbiturate Abuse

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MGI Mouse Phenotypes related to Barbiturate Abuse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.61 ATP12A HCRT IGBP1 MAOA MAOB OPRM1
2 nervous system MP:0003631 9.23 HCRT IGBP1 MAOA MAOB OPRM1 POMC
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Drugs & Therapeutics for Barbiturate Abuse

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Search Clinical Trials , NIH Clinical Center for Barbiturate Abuse

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Genetic Tests for Barbiturate Abuse

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Anatomical Context for Barbiturate Abuse

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Publications for Barbiturate Abuse

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Articles related to Barbiturate Abuse:

(show all 16)
# Title Authors PMID Year
1
Transient diffuse cerebral hypoperfusion in Tc-99m HMPAO SPECT of the brain during withdrawal syndrome following acute barbiturate poisoning. 61
12458639 2002
2
Is a history of alcohol problems or of psychiatric disorder associated with attrition at 11-year follow-up? 61
8827158 1996
3
Severe barbiturate withdrawal syndrome in migrainous patients. 61
8742687 1996
4
[Capsular retraction of the hip]. 61
8333704 1993
5
Nonconvulsive status epilepticus and barbiturate abuse. 61
3601101 1987
6
Epileptiform abnormalities discovered on electroencephalographic screening of psychiatric inpatients. 61
2881532 1987
7
[EEG changes in the withdrawal phase of tranquilizer or drug abuse]. 61
3084203 1986
8
Analytical aspects of barbiturate abuse: identification of drugs by the effective combination of gas-liquid, high-performance liquid and thin-layer chromatographic techniques. 61
7217255 1981
9
Barbiturate abuse. 61
7432278 1980
10
Fatal hyperthermia following haloperidol therapy of sedative-hypnotic withdrawal. 61
681307 1978
11
Barbiturate abuse. 61
940139 1976
12
Drug addiction in pregnancy and the neonate. 61
1266895 1976
13
Barbiturate abuse-a growing broblem. 61
1161516 1975
14
Diazepam, alcohol, and barbiturate abuse. 61
5124414 1971
15
Barbiturate abuse and addiction and their relationship to alcohol and alcoholism. 61
4924250 1971
16
New developments in barbiturate abuse. 61
5520390 1970
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Variations for Barbiturate Abuse

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Expression for Barbiturate Abuse

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Search GEO for disease gene expression data for Barbiturate Abuse.
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Pathways for Barbiturate Abuse

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Pathways related to Barbiturate Abuse according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Prion disease 36
Show member pathways
 12.48 SLC18A2 SLC18A1 MAOB MAOA
2
Circadian entrainment 36
Show member pathways
 12.41 SLC18A2 SLC18A1 MAOB MAOA
3
Amphetamine addiction 36
Show member pathways
 11.53 SLC18A2 SLC18A1 MAOB MAOA
4
Interleukin-4 and 13 signaling 65
11.49 POMC OPRM1 MAOA
5
Histidine metabolism 36
Show member pathways
 11.03 MAOB MAOA
6
Serotonergic synapse 36
10.98 SLC18A2 SLC18A1 MAOB MAOA
7
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 60
10.94 SLC18A2 MAOA
8
Sympathetic Nerve Pathway (Neuroeffector Junction) 60
10.84 SLC18A2 SLC18A1
9
noradrenaline and adrenaline degradation 1
Show member pathways
 10.61 MAOB MAOA
10
Dopamine metabolism 1
10.51 MAOB MAOA
11
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.49 SLC18A2 MAOB MAOA
12
putrescine degradation III 1
Show member pathways
 10.44 MAOB MAOA
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GO Terms for Barbiturate Abuse

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Cellular components related to Barbiturate Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 8.62 SLC18A2 SLC18A1

Biological processes related to Barbiturate Abuse according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.51 ATP4A ATP12A
2 neuropeptide signaling pathway GO:0007218 9.5 POMC OPRM1 HCRT
3 eating behavior GO:0042755 9.49 OPRM1 HCRT
4 cellular sodium ion homeostasis GO:0006883 9.48 ATP4A ATP12A
5 sodium ion export across plasma membrane GO:0036376 9.46 ATP4A ATP12A
6 cellular potassium ion homeostasis GO:0030007 9.43 ATP4A ATP12A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.4 ATP4A ATP12A
8 neurotransmitter catabolic process GO:0042135 9.37 MAOB MAOA
9 dopamine catabolic process GO:0042420 9.26 MAOB MAOA
10 monoamine transport GO:0015844 9.16 SLC18A2 SLC18A1
11 serotonin uptake GO:0051610 8.96 SLC18A2 SLC18A1
12 aminergic neurotransmitter loading into synaptic vesicle GO:0015842 8.62 SLC18A2 SLC18A1

Molecular functions related to Barbiturate Abuse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.37 ATP4A ATP12A
2 monoamine transmembrane transporter activity GO:0008504 9.32 SLC18A2 SLC18A1
3 potassium-transporting ATPase activity GO:0008556 9.26 ATP4A ATP12A
4 primary amine oxidase activity GO:0008131 9.16 MAOB MAOA
5 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
6 serotonin:sodium symporter activity GO:0005335 8.62 SLC18A2 SLC18A1
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Sources for Barbiturate Abuse

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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