MCID: BRB002
MIFTS: 24

Barbiturate Dependence

Categories: Mental diseases

Aliases & Classifications for Barbiturate Dependence

MalaCards integrated aliases for Barbiturate Dependence:

Name: Barbiturate Dependence 12 74 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2575
ICD9CM 34 304.11
UMLS 71 C0154482 C0338767

Summaries for Barbiturate Dependence

Disease Ontology : 12 A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance.

MalaCards based summary : Barbiturate Dependence is related to withdrawal disorder and adjustment disorder. An important gene associated with Barbiturate Dependence is APEH (Acylaminoacyl-Peptide Hydrolase), and among its related pathways/superpathways are Ca, cAMP and Lipid Signaling and Brain-Derived Neurotrophic Factor (BDNF) signaling pathway. Affiliated tissues include brain, spinal cord and hypothalamus, and related phenotype is integument.

Wikipedia : 74 Barbiturate dependence develops with regular use of barbiturates. This in turn may lead to a need for... more...

Related Diseases for Barbiturate Dependence

Graphical network of the top 20 diseases related to Barbiturate Dependence:



Diseases related to Barbiturate Dependence

Symptoms & Phenotypes for Barbiturate Dependence

MGI Mouse Phenotypes related to Barbiturate Dependence:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.1 APEH GRIA2 IKBKG PLCG1 SLC6A4 TPH1

Drugs & Therapeutics for Barbiturate Dependence

Search Clinical Trials , NIH Clinical Center for Barbiturate Dependence

Genetic Tests for Barbiturate Dependence

Anatomical Context for Barbiturate Dependence

MalaCards organs/tissues related to Barbiturate Dependence:

40
Brain, Spinal Cord, Hypothalamus

Publications for Barbiturate Dependence

Articles related to Barbiturate Dependence:

(show all 30)
# Title Authors PMID Year
1
Quantitative trait loci affecting risk for pentobarbital withdrawal map near alcohol withdrawal loci on mouse chromosomes 1, 4, and 11. 61
10337613 1999
2
[Barbiturate dependence]. 61
2762911 1989
3
Alterations in dopamine and 5-hydroxytryptamine (5-HT) function during barbiturate dependence and withdrawal in mice. 61
22158891 1987
4
Continuously infused 2-amino-7-phosphonoheptanoic acid antagonizes N-methyl-D-aspartate-induced elevations of cyclic GMP in vivo in multiple brain areas and chemically-induced seizure activity. 61
2877414 1986
5
Investigation of clonidine and lofexidine for the treatment of barbiturate withdrawal in mice. 61
4082462 1985
6
Continuous intraperitoneal infusion of pentobarbital: a model of barbiturate dependence in the rat. 61
4038416 1985
7
Increased susceptibility of audiogenic rats to barbital withdrawal convulsions. 61
6685882 1983
8
[Self-stimulation reaction of the hypothalamus in single and repeat administrations of ethaminal sodium]. 61
6682806 1983
9
Barbiturate dependence and drug preference. 61
7195034 1981
10
Barbiturate dependence in mice: effects of propranolol on the withdrawal syndrome. 61
7189885 1980
11
An improved technique for the induction of barbiturate dependence in mice. 61
7189567 1980
12
Withdrawal treatment for barbiturate dependence. 61
482237 1979
13
Changes in brain levels of cyclic nucleotides and gamma-aminobutyric acid in barbiturate dependence and withdrawal. 61
222596 1979
14
[Problems with hypnotic drug abuse and its therapy (author's transl)]. 61
293098 1979
15
Loss of inhibition in the spinal cord during barbiturate withdrawal. 61
566321 1978
16
Barbiturate dependence in mice: evidence for beta-adrenergic receptor proliferation in brain. 61
209505 1978
17
Experimental barbiturate dependence. I. Barbiturate dependence development in rats by drug-admixed food (DAF) method. 61
418446 1978
18
Barbiturate dependence in mice: effects of continuous vs. discontinuous drug administration. 61
402673 1977
19
The moral choice in prescribing barbiturates. 61
940140 1976
20
What is barbiturate dependence and who is at risk? 61
940138 1976
21
Tolerance characteristics produced during the maximally tolerable chronic pentobarbital dosing in the cat. 61
1120956 1975
22
[Barbiturate dependence at the cellular level]. 61
809158 1975
23
Some endocrinological aspects of barbiturate dependence. 61
5103092 1971
24
Phenobarbital technique for treatment of barbiturate dependence. 61
5538852 1971
25
Reduction of barbiturate dependence induced by repeated electroconvulsions. 61
4331780 1970
26
Treatment of barbiturate dependence. 61
5468943 1970
27
The syndrome of barbiturate dependence. 61
5493326 1970
28
A new method for treatment of barbiturate dependence. 61
5467903 1970
29
Personality factors and barbiturate dependence. 61
5264294 1970
30
Barbiturate dependence. 61
5801260 1969

Variations for Barbiturate Dependence

Expression for Barbiturate Dependence

Search GEO for disease gene expression data for Barbiturate Dependence.

Pathways for Barbiturate Dependence

Pathways related to Barbiturate Dependence according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.24 PLCG1 MARCKS GRIA2
2 11.08 PLCG1 MARCKS IKBKG GRIA2
3 10.92 GRIA2 GABRR3
4 10.78 PLCG1 GRIA2
5 10.6 TPH1 SLC6A4

GO Terms for Barbiturate Dependence

Biological processes related to Barbiturate Dependence according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inositol phosphate metabolic process GO:0043647 8.96 PLCG1 INPP1
2 protein homooligomerization GO:0051260 8.8 SLC6A4 MARCKS EHD1

Sources for Barbiturate Dependence

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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