MCID: BRT013
MIFTS: 30

Baritosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Baritosis

MalaCards integrated aliases for Baritosis:

Name: Baritosis 12 74 52 43 15 71
Deposition of Barium in the Lungs 52
Inhalation of Barytes 52

Classifications:



External Ids:

Disease Ontology 12 DOID:10321
MeSH 43 C537080
NCIt 49 C34410
SNOMED-CT 67 50076003
UMLS 71 C0340177

Summaries for Baritosis

NIH Rare Diseases : 52 Baritosis is an extremely rare, benign form of pneumoconiosis that causes little or no overgrowth, hardening, and/or scarring of the tissue in the lung (fibrosis). Pneumoconiosis is caused by accumulation of inhaled particles and involves a reaction of tissue in the lung. In the case of baritosis, the inhaled particles are made up of barium sulfate and is well described in workers who crush and grind compounds containing barium, a mineral found in paints, paper, ceramics, glass, rubber, electronic components, and in drilling muds in oil and gas exploration. Baritosis is typically characterized by a mixture of very fine punctate and annular (ring-like) lesions and some slightly larger nodular lesions in the lung. The condition generally appears 1 to 2 years after exposure, does not affect the function of the lung, and appears to go away without treatment after exposure stops.

MalaCards based summary : Baritosis, also known as deposition of barium in the lungs, is related to pneumoconiosis and anthracosis. An important gene associated with Baritosis is PARTICL (Promoter Of MAT2A Antisense Radiation-Induced Circulating Long Non-Coding RNA), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Apelin signaling pathway. Affiliated tissues include lung, lymph node and bone marrow, and related phenotypes are cardiovascular system and mortality/aging

Wikipedia : 74 Baritosis is a benign type of pneumoconiosis, which is caused by long-term exposure to barium... more...

Related Diseases for Baritosis

Graphical network of the top 20 diseases related to Baritosis:



Diseases related to Baritosis

Symptoms & Phenotypes for Baritosis

MGI Mouse Phenotypes related to Baritosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 CSF1 EHD4 FIG4 MPO NOS2 SLC34A2
2 mortality/aging MP:0010768 10.03 CSF1 EHD4 FIG4 HAUS3 MNT MPO
3 limbs/digits/tail MP:0005371 9.8 CSF1 FIG4 PSMD5 SMAD4 STAT1 TIMP1
4 muscle MP:0005369 9.7 CSF1 FIG4 MPO NOS2 SMAD4 SPP1
5 neoplasm MP:0002006 9.43 MNT NOS2 SMAD4 SPP1 STAT1 TIMP1
6 skeleton MP:0005390 9.28 CSF1 FIG4 MNT NOS2 PSMD5 SMAD4

Drugs & Therapeutics for Baritosis

Search Clinical Trials , NIH Clinical Center for Baritosis

Cochrane evidence based reviews: baritosis

Genetic Tests for Baritosis

Anatomical Context for Baritosis

MalaCards organs/tissues related to Baritosis:

40
Lung, Lymph Node, Bone Marrow, Bone, Myeloid

Publications for Baritosis

Articles related to Baritosis:

(show all 21)
# Title Authors PMID Year
1
Twenty Element Concentrations in Human Organs Determined by Two-Jet Plasma Atomic Emission Spectrometry. 61
31772512 2019
2
State-of-the-art nanopathological diagnostics. 61
28805487 2017
3
Pneumoconiosis: comparison of imaging and pathologic findings. 61
16418244 2006
4
Baritosis of the mediastinal lymph nodes. 61
12842570 2003
5
Silicosis in barium miners. 61
3787542 1986
6
Baritosis: a benign pneumoconiosis. 61
1257935 1976
7
[Baritosis: initial results of a survey in 2 Algerian factories]. 61
5741662 1968
8
[Baritosis and tin oxide lung]. 61
5985586 1966
9
[Apropos of 57 cases of pulmonary baritosis. (Results of a systematic investigation in a baryta factory)]. 61
5942694 1966
10
[On a case of baritosis]. 61
14026844 1962
11
[A case of occupational baritosis treated without success with disodium calcitetracemate (Ca-EDTA)]. 61
14473388 1962
12
[A case of pulmonary baritosis in a patient with scleroderma]. 61
14475385 1962
13
[A case of occupational baritosis treated without success by calcium disodium tetracetate (CaEDTA)]. 61
14473387 1961
14
[A rare pneumoconiosis: baritosis]. 61
14465220 1961
15
[Problem of baritosis]. 61
13562485 1958
16
[Case of occupational baritosis]. 61
13339669 1956
17
[Roentgenologic diagnosis of baritosis; experimental investigations]. 61
13169619 1954
18
Baritosis; report of a case. 61
13007199 1953
19
[Baritosis]. 61
13125939 1953
20
[Study of two cases of non-silicotic pneumoconiosis observed in Italy: thio-pneumoconiosis and baritosis]. 61
14790764 1950
21
[Forms of pneumoconiosis especially studied in Italy; thiopneumoconiosis and baritosis]. 61
15423130 1950

Variations for Baritosis

Expression for Baritosis

Search GEO for disease gene expression data for Baritosis.

Pathways for Baritosis

Pathways related to Baritosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.09 TIMP1 STAT1 NOS2 MPO
2 11.68 SPP1 SMAD4 NOS2
3 11.39 TIMP1 STAT1 NOS2
4 10.6 TIMP1 STAT1
5 10.56 STAT1 SPP1 SMAD4
6 10.16 MPO CSF1

GO Terms for Baritosis

Cellular components related to Baritosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.1 STAT1 SPP1 NOS2 EHD4 CSF1 ASPSCR1

Biological processes related to Baritosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.56 TIMP1 SPP1 PSMD5 CSF1
2 cytokine-mediated signaling pathway GO:0019221 9.26 TIMP1 STAT1 NOS2 CSF1
3 interleukin-6-mediated signaling pathway GO:0070102 9.16 STAT1 SMAD4
4 cellular protein metabolic process GO:0044267 8.92 TIMP1 SPP1 SLC34A2 CSF1

Sources for Baritosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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