Baritosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Baritosis

MalaCards integrated aliases for Baritosis:

Name: Baritosis ¹² ⁷⁴ ²⁰ ⁴⁴ ¹⁵ ⁷¹

Deposition of Barium in the Lungs ²⁰

Inhalation of Barytes ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:10321

MeSH ⁴⁴ C537080

NCIt ⁵⁰ C34410

SNOMED-CT ⁶⁷ 50076003

UMLS ⁷¹ C0340177

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Summaries for Baritosis

GARD : ²⁰ Baritosis is an extremely rare, benign form of pneumoconiosis that causes little or no overgrowth, hardening, and/or scarring of the tissue in the lung (fibrosis). Pneumoconiosis is caused by accumulation of inhaled particles and involves a reaction of tissue in the lung. In the case of baritosis, the inhaled particles are made up of barium sulfate and is well described in workers who crush and grind compounds containing barium, a mineral found in paints, paper, ceramics, glass, rubber, electronic components, and in drilling muds in oil and gas exploration. Baritosis is typically characterized by a mixture of very fine punctate and annular (ring-like) lesions and some slightly larger nodular lesions in the lung. The condition generally appears 1 to 2 years after exposure, does not affect the function of the lung, and appears to go away without treatment after exposure stops.

MalaCards based summary : Baritosis, also known as deposition of barium in the lungs, is related to anthracosis and pneumoconiosis. An important gene associated with Baritosis is TACR2 (Tachykinin Receptor 2), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. Affiliated tissues include lung, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : ⁷⁴ Baritosis is a benign type of pneumoconiosis, which is caused by long-term exposure to barium... more...

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Related Diseases for Baritosis

Diseases related to Baritosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)

#	Related Disease	Score	Top Affiliating Genes
1	anthracosis	30.5	IL1B CXCL8
2	pneumoconiosis	30.2	SPP1 IL1B CXCL8
3	leukoregulin	10.2	CXCL8 CSF1
4	mycetoma	10.2	NOS2 CXCL8
5	tympanosclerosis	10.2	SPP1 NOS2
6	eales disease	10.2	NOS2 IL1B
7	acute pericementitis	10.1	IL1B CXCL8
8	stachybotrys chartarum	10.1	IL1B CSF1
9	suppurative periapical periodontitis	10.1	IL1B CXCL8
10	periapical periodontitis	10.1	IL1B CXCL8
11	bacterial conjunctivitis	10.1	IL1B CXCL8
12	tracheitis	10.1	IL1B CXCL8
13	recurrent corneal erosion	10.1	IL1B CXCL8
14	tungiasis	10.1	IL1B CXCL8
15	vaginal discharge	10.1	IL1B CXCL8
16	irritant dermatitis	10.1	IL1B CXCL8
17	dental pulp disease	10.1	IL1B CXCL8
18	trichomoniasis	10.1	IL1B CXCL8
19	chlamydia pneumonia	10.1	IL1B CXCL8
20	inflammatory bowel disease 14	10.1	TIMP1 SPP1
21	bagassosis	10.0	IL1B CXCL8
22	wells syndrome	10.0	IL1B CXCL8
23	urethritis	10.0	IL1B CXCL8
24	duodenum cancer	10.0	SMAD4 GAST
25	funisitis	10.0	IL1B CXCL8
26	pyelitis	10.0	OGA IL1B CXCL8
27	tooth resorption	10.0	SPP1 IL1B
28	crohn's colitis	10.0	NOS2 IL1B CXCL8
29	blood group, globoside system	10.0	IL1B CXCL8
30	peptic esophagitis	10.0	IL1B GAST CXCL8
31	esophagitis	10.0	IL1B GAST CXCL8
32	bacterial sepsis	10.0	NOS2 IL1B CXCL8
33	peripheral vascular disease	10.0	TIMP1 NOS2 GAST
34	gastric ulcer	10.0	IL1B GAST CXCL8
35	cutaneous leishmaniasis	10.0	NOS2 IL1B CXCL8
36	cardiac sarcoidosis	10.0	IL1B CXCL8
37	pulmonary edema	10.0	NOS2 IL1B CXCL8
38	chlamydia	10.0	NOS2 IL1B CXCL8
39	cyclic neutropenia	10.0	IL1B CXCL8 CSF1
40	peptic ulcer disease	10.0	IL1B GAST CXCL8
41	acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	10.0	MPO CSF1
42	duodenal ulcer	10.0	IL1B GAST CXCL8
43	aseptic meningitis	10.0	IL1B CXCL8 CSF1
44	toxic shock syndrome	10.0	NOS2 IL1B CXCL8
45	chronic conjunctivitis	10.0	IL1B CXCL8
46	atrophic gastritis	10.0	IL1B GAST CXCL8
47	chagas disease	10.0	NOS2 IL1B CXCL8
48	tendinitis	10.0	SPP1 IL1B
49	visceral leishmaniasis	10.0	NOS2 IL1B CXCL8
50	cecal disease	10.0	IL1B CXCL8

Graphical network of the top 20 diseases related to Baritosis:

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Symptoms & Phenotypes for Baritosis

MGI Mouse Phenotypes related to Baritosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.07	CSF1 GAST IL1B MPO NOS2 SLC34A2
2	cardiovascular system	MP:0005385	10.06	CSF1 IL1B MPO NOS2 SLC34A2 SMAD4
3	mortality/aging	MP:0010768	10	CSF1 GAST IL1B MPO NOS2 OGA
4	immune system	MP:0005387	9.97	CSF1 GAST IL1B MPO NOS2 SMAD4
5	muscle	MP:0005369	9.63	CSF1 MPO NOS2 SMAD4 SPP1 STAT1
6	neoplasm	MP:0002006	9.5	GAST IL1B NOS2 SMAD4 SPP1 STAT1
7	respiratory system	MP:0005388	9.17	CSF1 NOS2 OGA SLC34A2 SPP1 STAT1

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Drugs & Therapeutics for Baritosis

Search Clinical Trials , NIH Clinical Center for Baritosis

Cochrane evidence based reviews: baritosis

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Genetic Tests for Baritosis

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Anatomical Context for Baritosis

MalaCards organs/tissues related to Baritosis:

⁴⁰

Lung

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Publications for Baritosis

Articles related to Baritosis:

(show all 21)

#	Title	Authors	PMID	Year
1	Twenty Element Concentrations in Human Organs Determined by Two-Jet Plasma Atomic Emission Spectrometry. ⁶¹	Zaksas NP...Nevinsky GA	31772512	2019
2	State-of-the-art nanopathological diagnostics. ⁶¹	Roncati L...Barbolini G	28805487	2017
3	Pneumoconiosis: comparison of imaging and pathologic findings. ⁶¹	Chong S...Kim TS	16418244	2006
4	Baritosis of the mediastinal lymph nodes. ⁶¹	Dosios T...Karydas AG	12842570	2003
5	Silicosis in barium miners. ⁶¹	Seaton A...Brown WR	3787542	1986
6	Baritosis: a benign pneumoconiosis. ⁶¹	Doig AT	1257935	1976
7	[Baritosis: initial results of a survey in 2 Algerian factories]. ⁶¹	Drif M...de Grooth H	5741662	1968
8	[Baritosis and tin oxide lung]. ⁶¹	Zorn O	5985586	1966
9	[Apropos of 57 cases of pulmonary baritosis. (Results of a systematic investigation in a baryta factory)]. ⁶¹	Levi-Valensi P...Hadjadj G	5942694	1966
10	[On a case of baritosis]. ⁶¹	DELWAULLE P	14026844	1962
11	[A case of occupational baritosis treated without success with disodium calcitetracemate (Ca-EDTA)]. ⁶¹	MICHAUX P...LAFFONT H	14473388	1962
12	[A case of pulmonary baritosis in a patient with scleroderma]. ⁶¹	MONGIN M...LALLEMAND M	14475385	1962
13	[A case of occupational baritosis treated without success by calcium disodium tetracetate (CaEDTA)]. ⁶¹	MICHAUX P...LAFFONT H	14473387	1961
14	[A rare pneumoconiosis: baritosis]. ⁶¹	LIEPMANN M	14465220	1961
15	[Problem of baritosis]. ⁶¹	RUMIANTSEV GI	13562485	1958
16	[Case of occupational baritosis]. ⁶¹	MICHAUX P...THIODET J	13339669	1956
17	[Roentgenologic diagnosis of baritosis; experimental investigations]. ⁶¹	VIDERLI MM	13169619	1954
18	[Baritosis]. ⁶¹	BRANISAVLJEVIC M...TEOFANOVIC S	13125939	1953
19	Baritosis; report of a case. ⁶¹	PENDERGRASS EP...GREENING RR	13007199	1953
20	[Study of two cases of non-silicotic pneumoconiosis observed in Italy: thio-pneumoconiosis and baritosis]. ⁶¹	PANCHERI G	14790764	1950
21	[Forms of pneumoconiosis especially studied in Italy; thiopneumoconiosis and baritosis]. ⁶¹	PANCHERI G	15423130	1950

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Genes for Baritosis

Genes related to Baritosis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TACR2	Tachykinin Receptor 2	Protein Coding	5.18	DISEASES inferred ¹⁵
2	SLC34A2	Solute Carrier Family 34 Member 2	Protein Coding	5	DISEASES inferred ¹⁵
3	OGA	O-GlcNAcase	Protein Coding	4.12	DISEASES inferred ¹⁵
4	NOS2	Nitric Oxide Synthase 2	Protein Coding	3.86	DISEASES inferred ¹⁵
5	GAST	Gastrin	Protein Coding	3.66	DISEASES inferred ¹⁵
6	CSF1	Colony Stimulating Factor 1	Protein Coding	3.64	DISEASES inferred ¹⁵
7	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	3.5	DISEASES inferred ¹⁵
8	SMAD4	SMAD Family Member 4	Protein Coding	3.42	DISEASES inferred ¹⁵
9	SPP1	Secreted Phosphoprotein 1	Protein Coding	3.41	DISEASES inferred ¹⁵
10	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	3.4	DISEASES inferred ¹⁵
11	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	3.33	DISEASES inferred ¹⁵
12	MPO	Myeloperoxidase	Protein Coding	3.31	DISEASES inferred ¹⁵
13	IL1B	Interleukin 1 Beta	Protein Coding	3.25	DISEASES inferred ¹⁵

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Variations for Baritosis

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Expression for Baritosis

Search GEO for disease gene expression data for Baritosis.

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Pathways for Baritosis

Pathways related to Baritosis according to GeneCards Suite gene sharing:

(show all 31)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.61	TIMP1 STAT1 SPP1 SMAD4 NOS2 IL1B
2	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.19	TIMP1 STAT1 NOS2 IL1B CXCL8 CSF1
3	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.8	STAT1 SPP1 SMAD4 NOS2 IL1B CXCL8
4	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²³ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²³ Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²³ NOD-like Receptor Signaling Pathways ⁶⁴	12.58	STAT1 NOS2 IL1B CXCL8
5	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.3	TIMP1 STAT1 NOS2 MPO IL1B
6	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²³ iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.16	STAT1 NOS2 IL1B CXCL8
7	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.12	TIMP1 STAT1 IL1B CXCL8
8	Colorectal Cancer Metastasis ⁶³	12.04	STAT1 SMAD4 NOS2
9	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	11.98	STAT1 NOS2 IL1B CXCL8
10	Apelin signaling pathway ³⁶	11.95	SPP1 SMAD4 NOS2
11	Osteoclast differentiation ³⁶	11.91	STAT1 IL1B CSF1
12	Spinal Cord Injury ¹	11.88	NOS2 IL1B CXCL8
13	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	11.85	STAT1 NOS2 IL1B
14	Senescence and Autophagy in Cancer ¹	11.81	SMAD4 IL1B CXCL8
15	Amoebiasis ³⁶	11.78	NOS2 IL1B CXCL8
16	Rheumatoid arthritis ³⁶	11.73	IL1B CXCL8 CSF1
17	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.71	STAT1 SMAD4 IL1B
18	Pertussis ³⁶	11.62	NOS2 IL1B CXCL8
19	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.62	STAT1 SMAD4 IL1B CXCL8
20	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.5	NOS2 IL1B CXCL8
21	TGF-beta Receptor Signaling (WikiPathways) ¹	11.45	STAT1 SPP1 SMAD4
22	Hepatitis C and Hepatocellular Carcinoma ¹	11.38	SMAD4 NOS2 CXCL8
23	MSP-RON Signaling ⁶³	11.33	NOS2 IL1B CSF1
24	Lung fibrosis ¹	11.26	TIMP1 SPP1 IL1B CXCL8
25	Type II interferon signaling (IFNG) ¹	11.15	STAT1 NOS2 IL1B
26	Interleukin-4 and 13 signaling ⁶⁵	11.08	TIMP1 STAT1 NOS2 IL1B CXCL8
27	IL1 and megakaryocytes in obesity ¹	11.05	TIMP1 IL1B
28	Interleukin-10 signaling ⁶⁵	10.95	TIMP1 IL1B CXCL8 CSF1
29	Immune response_Oncostatin M signaling via JAK-Stat in human cells ²³	10.92	TIMP1 STAT1
30	G-protein signaling_Rap2B regulation pathway ²³	10.85	TIMP1 SPP1 IL1B CXCL8 CSF1
31	LDL Oxidation in Atherogenesis ⁶³	10.64	MPO IL1B CSF1

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GO Terms for Baritosis

Cellular components related to Baritosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.5	TIMP1 SPP1 MPO IL1B GAST CXCL8
2	extracellular space	GO:0005615	9.17	TIMP1 SPP1 MPO IL1B GAST CXCL8

Biological processes related to Baritosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	9.76	TIMP1 TACR2 STAT1 SPP1 IL1B GAST
2	cellular response to lipopolysaccharide	GO:0071222	9.61	NOS2 IL1B CXCL8
3	defense response	GO:0006952	9.58	STAT1 MPO CXCL8
4	cellular protein metabolic process	GO:0044267	9.56	TIMP1 SPP1 SLC34A2 CSF1
5	response to food	GO:0032094	9.37	MPO GAST
6	inflammatory response	GO:0006954	9.35	SPP1 NOS2 IL1B CXCL8 CSF1
7	interleukin-6-mediated signaling pathway	GO:0070102	9.32	STAT1 SMAD4
8	cytokine-mediated signaling pathway	GO:0019221	9.1	TIMP1 STAT1 NOS2 IL1B CXCL8 CSF1

Molecular functions related to Baritosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.02	TIMP1 SPP1 IL1B CXCL8 CSF1

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Sources for Baritosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia