MCID: BRT013
MIFTS: 33

Baritosis

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Baritosis

MalaCards integrated aliases for Baritosis:

Name: Baritosis 12 74 20 44 15 71
Deposition of Barium in the Lungs 20
Inhalation of Barytes 20

Classifications:



External Ids:

Disease Ontology 12 DOID:10321
MeSH 44 C537080
NCIt 50 C34410
SNOMED-CT 67 50076003
UMLS 71 C0340177

Summaries for Baritosis

GARD : 20 Baritosis is an extremely rare, benign form of pneumoconiosis that causes little or no overgrowth, hardening, and/or scarring of the tissue in the lung (fibrosis). Pneumoconiosis is caused by accumulation of inhaled particles and involves a reaction of tissue in the lung. In the case of baritosis, the inhaled particles are made up of barium sulfate and is well described in workers who crush and grind compounds containing barium, a mineral found in paints, paper, ceramics, glass, rubber, electronic components, and in drilling muds in oil and gas exploration. Baritosis is typically characterized by a mixture of very fine punctate and annular (ring-like) lesions and some slightly larger nodular lesions in the lung. The condition generally appears 1 to 2 years after exposure, does not affect the function of the lung, and appears to go away without treatment after exposure stops.

MalaCards based summary : Baritosis, also known as deposition of barium in the lungs, is related to anthracosis and pneumoconiosis. An important gene associated with Baritosis is TACR2 (Tachykinin Receptor 2), and among its related pathways/superpathways are ERK Signaling and Cytokine Signaling in Immune system. Affiliated tissues include lung, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 Baritosis is a benign type of pneumoconiosis, which is caused by long-term exposure to barium... more...

Related Diseases for Baritosis

Diseases related to Baritosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 anthracosis 30.5 IL1B CXCL8
2 pneumoconiosis 30.2 SPP1 IL1B CXCL8
3 leukoregulin 10.2 CXCL8 CSF1
4 mycetoma 10.2 NOS2 CXCL8
5 tympanosclerosis 10.2 SPP1 NOS2
6 eales disease 10.2 NOS2 IL1B
7 acute pericementitis 10.1 IL1B CXCL8
8 stachybotrys chartarum 10.1 IL1B CSF1
9 suppurative periapical periodontitis 10.1 IL1B CXCL8
10 periapical periodontitis 10.1 IL1B CXCL8
11 bacterial conjunctivitis 10.1 IL1B CXCL8
12 tracheitis 10.1 IL1B CXCL8
13 recurrent corneal erosion 10.1 IL1B CXCL8
14 tungiasis 10.1 IL1B CXCL8
15 vaginal discharge 10.1 IL1B CXCL8
16 irritant dermatitis 10.1 IL1B CXCL8
17 dental pulp disease 10.1 IL1B CXCL8
18 trichomoniasis 10.1 IL1B CXCL8
19 chlamydia pneumonia 10.1 IL1B CXCL8
20 inflammatory bowel disease 14 10.1 TIMP1 SPP1
21 bagassosis 10.0 IL1B CXCL8
22 wells syndrome 10.0 IL1B CXCL8
23 urethritis 10.0 IL1B CXCL8
24 duodenum cancer 10.0 SMAD4 GAST
25 funisitis 10.0 IL1B CXCL8
26 pyelitis 10.0 OGA IL1B CXCL8
27 tooth resorption 10.0 SPP1 IL1B
28 crohn's colitis 10.0 NOS2 IL1B CXCL8
29 blood group, globoside system 10.0 IL1B CXCL8
30 peptic esophagitis 10.0 IL1B GAST CXCL8
31 esophagitis 10.0 IL1B GAST CXCL8
32 bacterial sepsis 10.0 NOS2 IL1B CXCL8
33 peripheral vascular disease 10.0 TIMP1 NOS2 GAST
34 gastric ulcer 10.0 IL1B GAST CXCL8
35 cutaneous leishmaniasis 10.0 NOS2 IL1B CXCL8
36 cardiac sarcoidosis 10.0 IL1B CXCL8
37 pulmonary edema 10.0 NOS2 IL1B CXCL8
38 chlamydia 10.0 NOS2 IL1B CXCL8
39 cyclic neutropenia 10.0 IL1B CXCL8 CSF1
40 peptic ulcer disease 10.0 IL1B GAST CXCL8
41 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0 MPO CSF1
42 duodenal ulcer 10.0 IL1B GAST CXCL8
43 aseptic meningitis 10.0 IL1B CXCL8 CSF1
44 toxic shock syndrome 10.0 NOS2 IL1B CXCL8
45 chronic conjunctivitis 10.0 IL1B CXCL8
46 atrophic gastritis 10.0 IL1B GAST CXCL8
47 chagas disease 10.0 NOS2 IL1B CXCL8
48 tendinitis 10.0 SPP1 IL1B
49 visceral leishmaniasis 10.0 NOS2 IL1B CXCL8
50 cecal disease 10.0 IL1B CXCL8

Graphical network of the top 20 diseases related to Baritosis:



Diseases related to Baritosis

Symptoms & Phenotypes for Baritosis

MGI Mouse Phenotypes related to Baritosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CSF1 GAST IL1B MPO NOS2 SLC34A2
2 cardiovascular system MP:0005385 10.06 CSF1 IL1B MPO NOS2 SLC34A2 SMAD4
3 mortality/aging MP:0010768 10 CSF1 GAST IL1B MPO NOS2 OGA
4 immune system MP:0005387 9.97 CSF1 GAST IL1B MPO NOS2 SMAD4
5 muscle MP:0005369 9.63 CSF1 MPO NOS2 SMAD4 SPP1 STAT1
6 neoplasm MP:0002006 9.5 GAST IL1B NOS2 SMAD4 SPP1 STAT1
7 respiratory system MP:0005388 9.17 CSF1 NOS2 OGA SLC34A2 SPP1 STAT1

Drugs & Therapeutics for Baritosis

Search Clinical Trials , NIH Clinical Center for Baritosis

Cochrane evidence based reviews: baritosis

Genetic Tests for Baritosis

Anatomical Context for Baritosis

MalaCards organs/tissues related to Baritosis:

40
Lung

Publications for Baritosis

Articles related to Baritosis:

(show all 21)
# Title Authors PMID Year
1
Twenty Element Concentrations in Human Organs Determined by Two-Jet Plasma Atomic Emission Spectrometry. 61
31772512 2019
2
State-of-the-art nanopathological diagnostics. 61
28805487 2017
3
Pneumoconiosis: comparison of imaging and pathologic findings. 61
16418244 2006
4
Baritosis of the mediastinal lymph nodes. 61
12842570 2003
5
Silicosis in barium miners. 61
3787542 1986
6
Baritosis: a benign pneumoconiosis. 61
1257935 1976
7
[Baritosis: initial results of a survey in 2 Algerian factories]. 61
5741662 1968
8
[Baritosis and tin oxide lung]. 61
5985586 1966
9
[Apropos of 57 cases of pulmonary baritosis. (Results of a systematic investigation in a baryta factory)]. 61
5942694 1966
10
[On a case of baritosis]. 61
14026844 1962
11
[A case of occupational baritosis treated without success with disodium calcitetracemate (Ca-EDTA)]. 61
14473388 1962
12
[A case of pulmonary baritosis in a patient with scleroderma]. 61
14475385 1962
13
[A case of occupational baritosis treated without success by calcium disodium tetracetate (CaEDTA)]. 61
14473387 1961
14
[A rare pneumoconiosis: baritosis]. 61
14465220 1961
15
[Problem of baritosis]. 61
13562485 1958
16
[Case of occupational baritosis]. 61
13339669 1956
17
[Roentgenologic diagnosis of baritosis; experimental investigations]. 61
13169619 1954
18
[Baritosis]. 61
13125939 1953
19
Baritosis; report of a case. 61
13007199 1953
20
[Study of two cases of non-silicotic pneumoconiosis observed in Italy: thio-pneumoconiosis and baritosis]. 61
14790764 1950
21
[Forms of pneumoconiosis especially studied in Italy; thiopneumoconiosis and baritosis]. 61
15423130 1950

Variations for Baritosis

Expression for Baritosis

Search GEO for disease gene expression data for Baritosis.

Pathways for Baritosis

Pathways related to Baritosis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 TIMP1 STAT1 SPP1 SMAD4 NOS2 IL1B
2
Show member pathways
13.19 TIMP1 STAT1 NOS2 IL1B CXCL8 CSF1
3
Show member pathways
12.8 STAT1 SPP1 SMAD4 NOS2 IL1B CXCL8
4
Show member pathways
12.58 STAT1 NOS2 IL1B CXCL8
5
Show member pathways
12.3 TIMP1 STAT1 NOS2 MPO IL1B
6
Show member pathways
12.16 STAT1 NOS2 IL1B CXCL8
7
Show member pathways
12.12 TIMP1 STAT1 IL1B CXCL8
8 12.04 STAT1 SMAD4 NOS2
9
Show member pathways
11.98 STAT1 NOS2 IL1B CXCL8
10 11.95 SPP1 SMAD4 NOS2
11 11.91 STAT1 IL1B CSF1
12 11.88 NOS2 IL1B CXCL8
13
Show member pathways
11.85 STAT1 NOS2 IL1B
14 11.81 SMAD4 IL1B CXCL8
15 11.78 NOS2 IL1B CXCL8
16 11.73 IL1B CXCL8 CSF1
17
Show member pathways
11.71 STAT1 SMAD4 IL1B
18 11.62 NOS2 IL1B CXCL8
19 11.62 STAT1 SMAD4 IL1B CXCL8
20
Show member pathways
11.5 NOS2 IL1B CXCL8
21 11.45 STAT1 SPP1 SMAD4
22 11.38 SMAD4 NOS2 CXCL8
23 11.33 NOS2 IL1B CSF1
24 11.26 TIMP1 SPP1 IL1B CXCL8
25 11.15 STAT1 NOS2 IL1B
26 11.08 TIMP1 STAT1 NOS2 IL1B CXCL8
27 11.05 TIMP1 IL1B
28 10.95 TIMP1 IL1B CXCL8 CSF1
29 10.92 TIMP1 STAT1
30 10.85 TIMP1 SPP1 IL1B CXCL8 CSF1
31 10.64 MPO IL1B CSF1

GO Terms for Baritosis

Cellular components related to Baritosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 TIMP1 SPP1 MPO IL1B GAST CXCL8
2 extracellular space GO:0005615 9.17 TIMP1 SPP1 MPO IL1B GAST CXCL8

Biological processes related to Baritosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.76 TIMP1 TACR2 STAT1 SPP1 IL1B GAST
2 cellular response to lipopolysaccharide GO:0071222 9.61 NOS2 IL1B CXCL8
3 defense response GO:0006952 9.58 STAT1 MPO CXCL8
4 cellular protein metabolic process GO:0044267 9.56 TIMP1 SPP1 SLC34A2 CSF1
5 response to food GO:0032094 9.37 MPO GAST
6 inflammatory response GO:0006954 9.35 SPP1 NOS2 IL1B CXCL8 CSF1
7 interleukin-6-mediated signaling pathway GO:0070102 9.32 STAT1 SMAD4
8 cytokine-mediated signaling pathway GO:0019221 9.1 TIMP1 STAT1 NOS2 IL1B CXCL8 CSF1

Molecular functions related to Baritosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TIMP1 SPP1 IL1B CXCL8 CSF1

Sources for Baritosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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